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Paul Thornalley

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Astrid Klooster; James R Larkin; Henri G D Leuvenink; gerjan navis; Paul J Thornalley; Harry van Goor; Janneke Wiersema-Buist; Reinold O B Gans; Stephan J L Bakker
Are brain and heart tissue prone to the development of thiamine deficiency?
Andrea F Lopez-Clavijo; Naila Rabbani; Paul J Thornalley; Mark P Barrow; Peter B O'Connor
Determination of types and binding sites of advanced glycation end products for substance P.
Naila Rabbani; Kasper Rossing; Peter Rossing; Lise Tarnow; Antonysunil Adaikalakoteswari; Hans-Henrik Parving; Paul J Thornalley
Effect of Irbesartan treatment on plasma and urinary markers of protein damage in patients with type 2 diabetes and microalbuminuria.

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2013: Astrid Klooster; James R Larkin; Henri G D Leuvenink; gerjan navis; Paul J Thornalley; Harry van Goor; Janneke Wiersema-Buist; Reinold O B Gans; Stephan J L Bakker
Are brain and heart tissue prone to the development of thiamine deficiency?
Alcohol (Fayetteville, N.Y.) 2013;47(3):215-21.
2012: Andrea F Lopez-Clavijo; Naila Rabbani; Paul J Thornalley; Mark P Barrow; Peter B O'Connor
Determination of types and binding sites of advanced glycation end products for substance P.
Analytical chemistry 2012;84(24):10568-75.
2012: Naila Rabbani; Kasper Rossing; Peter Rossing; Lise Tarnow; Antonysunil Adaikalakoteswari; Hans-Henrik Parving; Paul J Thornalley
Effect of Irbesartan treatment on plasma and urinary markers of protein damage in patients with type 2 diabetes and microalbuminuria.
Amino acids 2012;42(5):1627-39.
2012: Mingzhan Xue; Masayuki Yamamoto; M Maqsud Anwar; Precious Imbasi; Neil Kitteringham; Hiroshi Momiji; Takashi Moriguchi; B Kevin Park; Naila Rabbani; Tomokazu Souma; Paul J Thornalley
Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation.
The Biochemical journal 2012;443(1):213-22.
2012: Naila Rabbani; Paul J Thornalley
Amino Acids Glycation Section.
Amino acids 2012;42(4):1085-6.
2012: Naila Rabbani; Paul J Thornalley
Glycation research in amino acids: a place to call home.
Amino acids 2012;42(4):1087-96.
2012: Naila Rabbani; Paul J Thornalley
Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome.
Amino acids 2012;42(4):1133-42.
2012: Antonysunil Adaikalakoteswari; John M F Adam; Sri H K S Kariadi; Naila Rabbani; Askandar Tjokroprawiro; Sarwono Waspadji; Paul J Thornalley
Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia--link to renal status, glycemic control and vascular inflammation.
Diabetes research and clinical practice 2012;95(3):415-24.
2012: James R Larkin; Guerman Molostvov; Naila Rabbani; Daniel Zehnder; Fang Zhang; Lisa Godfrey; Paul J Thornalley
Glucose-induced down regulation of thiamine transporters in the kidney proximal tubular epithelium produces thiamine insufficiency in diabetes.
PloS one 2012;7(12):e53175.
2011: Naila Rabbani; Fozia Shaheen; Michèle Geoffrion; Lisa Godfrey; Ross Milne; Mingzhan Xue; Paul J Thornalley
Glycation of LDL by methylglyoxal increases arterial atherogenicity: a possible contributor to increased risk of cardiovascular disease in diabetes.
Diabetes 2011;60(7):1973-80.
2011: Naila Rabbani; Paul J Thornalley
Emerging role of thiamine therapy for prevention and treatment of early-stage diabetic nephropathy.
Diabetes, obesity & metabolism 2011;13(7):577-83.
2011: Lars P Kihm; Sandra Müller-Krebs; Julia Klein; Gregory Ehrlich; Laura Mertes; Marie-Luise Gross; Antonysunil Adaikalakoteswari; Paul J Thornalley; Hans-Peter Hammes; Peter P Nawroth; Martin Zeier; Vedat Schwenger
Benfotiamine protects against peritoneal and kidney damage in peritoneal dialysis.
Journal of the American Society of Nephrology : JASN 2011;22(5):914-26.
2011: Naila Rabbani; Paul J Thornalley
Glyoxalase in diabetes, obesity and related disorders.
Seminars in cell & developmental biology 2011;22(3):309-17.
2011: Mingzhan Xue; Naila Rabbani; Paul J Thornalley
Glyoxalase in ageing.
Seminars in cell & developmental biology 2011;22(3):293-301.
2011: Naila Rabbani; Paul J Thornalley
The glyoxalase system--from microbial metabolism, through ageing to human disease and multidrug resistance.
Seminars in cell & developmental biology 2011;22(3):261.
2011: Paul J Thornalley; Naila Rabbani
Glyoxalase in tumourigenesis and multidrug resistance.
Seminars in cell & developmental biology 2011;22(3):318-25.
2011: Michael P Murphy; Arne Holmgren; Nils-Göran Larsson; Barry Halliwell; Christopher J Chang; Balaraman Kalyanaraman; Sue Goo Rhee; Paul J Thornalley; Linda Partridge; David Gems; Thomas Nyström; Vsevolod Belousov; Paul T Schumacker; Christine C Winterbourn
Unraveling the biological roles of reactive oxygen species.
Cell metabolism 2011;13(4):361-6.
2011: Paul J Thornalley; Naila Rabbani
Protein damage in diabetes and uremia--identifying hotspots of proteome damage where minimal modification is amplified to marked pathophysiological effect.
Free radical research 2011;45(1):89-100.
2010: Paul J Thornalley; Naila Rabbani
Therapy: Vitamin B6, B9 and B12 in diabetic nephropathy--beware.
Nature reviews. Endocrinology 2010;6(9):477-8.
2010: Paul J Thornalley; Sahar Waris; Thomas Fleming; Thomas Santarius; Sarah J Larkin; Brigitte M Winklhofer-Roob; Michael R Stratton; Naila Rabbani
Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance.
Nucleic acids research 2010;38(16):5432-42.
2010: Thomas Santarius; Graham R Bignell; Chris Greenman; Sara Caroline Widaa; Lina Chen; Claire L Mahoney; Adam Butler; Sarah Edkins; Sahar Waris; Paul J Thornalley; P Andrew Futreal; Michael R Stratton
GLO1-A novel amplified gene in human cancer.
Genes, chromosomes & cancer 2010;49(8):711-25.
2010: Nikolaos Karachalias; Roya Babaei-Jadidi; Naila Rabbani; Paul J Thornalley
Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetes.
Diabetologia 2010;53(7):1506-16.
2010: Naila Rabbani; Madhu Varma Chittari; Charles W Bodmer; Daniel Zehnder; Antonio Ceriello; Paul J Thornalley
Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin.
Diabetes 2010;59(4):1038-45.
2009: Beatriz Duran-Jimenez; Darin Dobler; Sarah Moffatt; Naila Rabbani; Charles H Streuli; Paul J Thornalley; David R Tomlinson; Natalie J Gardiner
Advanced glycation end products in extracellular matrix proteins contribute to the failure of sensory nerve regeneration in diabetes.
Diabetes 2009;58(12):2893-903.
2009: Ilse Vanhorebeek; Jan Gunst; Björn Ellger; Magaly Boussemaere; Evelyne Lerut; Yves Debaveye; Naila Rabbani; Paul J Thornalley; Miet Schetz; Greet Van den Berghe
Hyperglycemic kidney damage in an animal model of prolonged critical illness.
Kidney international 2009;76(5):512-20.
2009: Ulrike Bechtold; Naila Rabbani; Philip M Mullineaux; Paul J Thornalley
Quantitative measurement of specific biomarkers for protein oxidation, nitration and glycation in Arabidopsis leaves.
The Plant journal : for cell and molecular biology 2009;59(4):661-71.
2009: Paul J Thornalley; Naila Rabbani
Highlights and hotspots of protein glycation in end-stage renal disease.
Seminars in dialysis 2009;22(4):400-4.
2009: Raymond Vanholder; Omar Abou-Deif; Angel Argiles; Ulrich Baurmeister; Joachim Beige; Peter Brouckaert; Philippe Brunet; Gerald Cohen; Peter Paul De Deyn; Tilman B Drüeke; Danilo Fliser; Griet Glorieux; Stefan Herget-Rosenthal; Walter H Hörl; Joachim Jankowski; Achim Jörres; Ziad A Massy; Mischak Harald; Alessandra F Perna; Juan Mariano Rodriguez-Portillo; Goce B Spasovski; Bernd G Stegmayr; Peter Stenvinkel; Paul J Thornalley; Christoph Wanner; Andrzej Wiecek
The role of EUTox in uremic toxin research.
Seminars in dialysis 2009;22(4):323-8.
2009: Ilse Vanhorebeek; Björn Ellger; Rita De Vos; Magaly Boussemaere; Yves Debaveye; Sarah Vander Perre; Naila Rabbani; Paul J Thornalley; Greet Van den Berghe
Tissue-specific glucose toxicity induces mitochondrial damage in a burn injury model of critical illness.
Critical care medicine 2009;37(4):1355-64.
2009: Naila Rabbani; Paul J Thornalley
Quantitation of markers of protein damage by glycation, oxidation, and nitration in peritoneal dialysis.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 2009;29 Suppl 2():S51-6.
2009: Naila Rabbani; S S Alam; S Riaz; James R Larkin; M W Akhtar; T Shafi; Paul J Thornalley
High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study.
Diabetologia 2009;52(2):208-12.
2009: Mingzhan Xue; Antonysunil Adaikalakoteswari; Naila Rabbani; Paul J Thornalley
Protein damage in the ageing process: advances in quantitation and the importance of enzymatic defences.
SEB experimental biology series 2009;62():227-65.
2009: Alexandra Wendler; Thorsten Irsch; Naila Rabbani; Paul J Thornalley; R Luise Krauth-Siegel
Glyoxalase II does not support methylglyoxal detoxification but serves as a general trypanothione thioesterase in African trypanosomes.
Molecular and biochemical parasitology 2009;163(1):19-27.
2008: Naila Rabbani; Paul J Thornalley
Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress.
Biochemical Society transactions 2008;36(Pt 5):1045-50.
2008: Mingzhan Xue; Qingwen Qian; Antonysunil Adaikalakoteswari; Naila Rabbani; Roya Babaei-Jadidi; Paul J Thornalley
Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease.
Diabetes 2008;57(10):2809-17.
2008: Thomas Fleming; Naila Rabbani; Paul J Thornalley
Preparation of nucleotide advanced glycation endproducts--imidazopurinone adducts formed by glycation of deoxyguanosine with glyoxal and methylglyoxal.
Annals of the New York Academy of Sciences 2008;1126():280-2.
2008: Usman Ahmed; Darin Dobler; Sarah J Larkin; Naila Rabbani; Paul J Thornalley
Reversal of hyperglycemia-induced angiogenesis deficit of human endothelial cells by overexpression of glyoxalase 1 in vitro.
Annals of the New York Academy of Sciences 2008;1126():262-4.
2008: Naila Rabbani; Paul J Thornalley
The dicarbonyl proteome: proteins susceptible to dicarbonyl glycation at functional sites in health, aging, and disease.
Annals of the New York Academy of Sciences 2008;1126():124-7.
2008: Paul J Thornalley
Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems--role in ageing and disease.
Drug metabolism and drug interactions 2008;23(1-2):125-50.
2008: Naila Rabbani; Paul J Thornalley
Assay of 3-nitrotyrosine in tissues and body fluids by liquid chromatography with tandem mass spectrometric detection.
Methods in enzymology 2008;440():337-59.
2007: Naila Rabbani; Katarina Sebekova; K Sebekova; August Heidland; Paul J Thornalley
Accumulation of free adduct glycation, oxidation, and nitration products follows acute loss of renal function.
Kidney international 2007;72(9):1113-21.
2007: Dachun Yao; Tetsuya Taguchi; Takeshi Matsumura; Richard G Pestell; Diane Edelstein; Ida Giardino; Guntram Suske; Naila Rabbani; Paul J Thornalley; Vijay P Sarthy; Hans-Peter Hammes; Michael Brownlee
High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A.
The Journal of biological chemistry 2007;282(42):31038-45.
2007: Paul J Thornalley; Roya Babaei-Jadidi; H Al Ali; Naila Rabbani; A Antonysunil; James R Larkin; A Ahmed; G Rayman; C W Bodmer
High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease.
Diabetologia 2007;50(10):2164-70.
2007: Paul J Thornalley
Dietary AGEs and ALEs and risk to human health by their interaction with the receptor for advanced glycation endproducts (RAGE)--an introduction.
Molecular nutrition & food research 2007;51(9):1107-10.
2007: Naila Ahmed; Paul J Thornalley
Advanced glycation endproducts: what is their relevance to diabetic complications?
Diabetes, obesity & metabolism 2007;9(3):233-45.
2007: Dachun Yao; Tetsuya Taguchi; Takeshi Matsumura; Richard G Pestell; Diane Edelstein; Ida Giardino; Guntram Suske; Naila Ahmed; Paul J Thornalley; Vijay P Sarthy; Hans-Peter Hammes; Michael Brownlee
Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription.
Cell 2007;128(3):625.
2007: Lijiang Song; Paul J Thornalley
Effect of storage, processing and cooking on glucosinolate content of Brassica vegetables.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2007;45(2):216-24.
2007: Paul J Thornalley
Endogenous alpha-oxoaldehydes and formation of protein and nucleotide advanced glycation endproducts in tissue damage.
Novartis Foundation symposium 2007;285():229-43; discussion 243-6.
2006: Paul J Thornalley
Advanced glycation end products in renal failure.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 2006;16(3):178-84.
2006: Darin Dobler; Naila Ahmed; Lijiang Song; Kevin E Eboigbodin; Paul J Thornalley
Increased dicarbonyl metabolism in endothelial cells in hyperglycemia induces anoikis and impairs angiogenesis by RGD and GFOGER motif modification.
Diabetes 2006;55(7):1961-9.
2006: Paul J Thornalley
Unease on the role of glyoxalase 1 in high-anxiety-related behaviour.
Trends in molecular medicine 2006;12(5):195-9.
2006: Dachun Yao; Tetsuya Taguchi; Takeshi Matsumura; Richard G Pestell; Diane Edelstein; Ida Giardino; Guntram Suske; Naila Ahmed; Paul J Thornalley; Vijay P Sarthy; Hans-Peter Hammes; Michael Brownlee
Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription.
Cell 2006;124(2):275-86.
2006: Jan P Nicolay; Juliane Schneider; Olivier M Niemoeller; Ferruh Artunc; Manuel Portero Otin; George Haik; Paul J Thornalley; Erwin Schleicher; Thomas Wieder; Florian Lang
Stimulation of suicidal erythrocyte death by methylglyoxal.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2006;18(4-5):223-32.
2005: Lijiang Song; John J Morrison; Nigel P Botting; Paul J Thornalley
Analysis of glucosinolates, isothiocyanates, and amine degradation products in vegetable extracts and blood plasma by LC-MS/MS.
Analytical biochemistry 2005;347(2):234-43.
2005: Paul J Thornalley
Measurement of protein glycation, glycated peptides, and glycation free adducts.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 2005;25(6):522-33.
2005: Paul J Thornalley
Glycation free adduct accumulation in renal disease: the new AGE.
Pediatric nephrology (Berlin, Germany) 2005;20(11):1515-22.
2005: Naila Ahmed; Roya Babaei-Jadidi; Scott K Howell; Paul J Thornalley; Paul J Beisswenger
Glycated and oxidized protein degradation products are indicators of fasting and postprandial hyperglycemia in diabetes.
Diabetes care 2005;28(10):2465-71.
2005: Paul J Thornalley
The potential role of thiamine (vitamin B1) in diabetic complications.
Current diabetes reviews 2005;1(3):287-98.
2005: Naila Ahmed; Roya Babaei-Jadidi; Scott K Howell; Paul J Beisswenger; Paul J Thornalley
Degradation products of proteins damaged by glycation, oxidation and nitration in clinical type 1 diabetes.
Diabetologia 2005;48(8):1590-603.
2005: Naila Ahmed; Bahar Mirshekar-Syahkal; Lauren Kennish; Nikolaos Karachalias; Roya Babaei-Jadidi; Paul J Thornalley
Assay of advanced glycation endproducts in selected beverages and food by liquid chromatography with tandem mass spectrometric detection.
Molecular nutrition & food research 2005;49(7):691-9.
2005: Jorge Berlanga; Danay Cibrian; Isabel Guillén; Freya Freyre; Jose S Alba; Pedro Lopez-Saura; Nelson Merino; Alfredo Aldama; Ana M Quintela; Maria E Triana; Jose F Montequin; hUSSAM Ajamieh; Dioslaida Urquiza; Naila Ahmed; Paul J Thornalley
Methylglyoxal administration induces diabetes-like microvascular changes and perturbs the healing process of cutaneous wounds.
Clinical science (London, England : 1979) 2005;109(1):83-95.
2005: Nikolaos Karachalias; Roya Babaei-Jadidi; Christian Kupich; Naila Ahmed; Paul J Thornalley
High-dose thiamine therapy counters dyslipidemia and advanced glycation of plasma protein in streptozotocin-induced diabetic rats.
Annals of the New York Academy of Sciences 2005;1043():777-83.
2005: Stamatina Agalou; Naila Ahmed; Paul J Thornalley; Anne Dawnay
Advanced glycation end product free adducts are cleared by dialysis.
Annals of the New York Academy of Sciences 2005;1043():734-9.
2005: Naila Ahmed; Reinhard Lüthen; Dieter Häussinger; Katarína Sebeková; Reinhard Schinzel; Wolfram Voelker; August Heidland; Paul J Thornalley
Increased protein glycation in cirrhosis and therapeutic strategies to prevent it.
Annals of the New York Academy of Sciences 2005;1043():718-24.
2005: Naila Ahmed; Paul J Thornalley
Peptide mapping of human serum albumin modified minimally by methylglyoxal in vitro and in vivo.
Annals of the New York Academy of Sciences 2005;1043():260-6.
2005: Paul J Thornalley
Dicarbonyl intermediates in the maillard reaction.
Annals of the New York Academy of Sciences 2005;1043():111-7.
2005: Stamatina Agalou; Naila Ahmed; Roya Babaei-Jadidi; Anne Dawnay; Paul J Thornalley
Profound mishandling of protein glycation degradation products in uremia and dialysis.
Journal of the American Society of Nephrology : JASN 2005;16(5):1471-85.
2005: Naila Ahmed; Darin Dobler; Mark Dean; Paul J Thornalley
Peptide mapping identifies hotspot site of modification in human serum albumin by methylglyoxal involved in ligand binding and esterase activity.
The Journal of biological chemistry 2005;280(7):5724-32.
2005: Naila Ahmed; Usman Ahmed; Paul J Thornalley; Klaus Hager; Gerd Fleischer; Gerald Münch
Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment.
Journal of neurochemistry 2005;92(2):255-63.
2004: Roya Babaei-Jadidi; Nikolaos Karachalias; C Kupich; Naila Ahmed; Paul J Thornalley
High-dose thiamine therapy counters dyslipidaemia in streptozotocin-induced diabetic rats.
Diabetologia 2004;47(12):2235-46.
2004: Naila Ahmed; Paul J Thornalley; Reinhard Lüthen; Dieter Häussinger; Katarina Sebekova; Reinhard Schinzel; Wolfram Voelker; August Heidland
Processing of protein glycation, oxidation and nitrosation adducts in the liver and the effect of cirrhosis.
Journal of hepatology 2004;41(6):913-9.
2004: Gail K McWalter; Larry G Higgins; Lesley I McLellan; Colin Henderson; Lijiang Song; Paul J Thornalley; Ken Itoh; Masayuki Yamamoto; John D Hayes
Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates.
The Journal of nutrition 2004;134(12 Suppl):3499S-3506S.
2004: Tadashi Jono; Ryoji Nagai; Xia Lin; Naila Ahmed; Paul J Thornalley; Motohiro Takeya; Seikoh Horiuchi
Nepsilon-(Carboxymethyl)lysine and 3-DG-imidazolone are major AGE structures in protein modification by 3-deoxyglucosone.
Journal of biochemistry 2004;136(3):351-8.
2004: Paul J Thornalley
Glycation, receptor-mediated cell activation and vascular complications of diabetes.
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2004;1(1):21-2.
2003: Nikolaos Karachalias; Roya Babaei-Jadidi; Naila Ahmed; Paul J Thornalley
Accumulation of fructosyl-lysine and advanced glycation end products in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats.
Biochemical Society transactions 2003;31(Pt 6):1423-5.
2003: Naila Ahmed; Paul J Thornalley
Quantitative screening of protein biomarkers of early glycation, advanced glycation, oxidation and nitrosation in cellular and extracellular proteins by tandem mass spectrometry multiple reaction monitoring.
Biochemical Society transactions 2003;31(Pt 6):1417-22.
2003: Stamatina Agalou; Naila Ahmed; Anne Dawnay; Paul J Thornalley
Removal of advanced glycation end products in clinical renal failure by peritoneal dialysis and haemodialysis.
Biochemical Society transactions 2003;31(Pt 6):1394-6.
2003: Paul J Thornalley
Protecting the genome: defence against nucleotide glycation and emerging role of glyoxalase I overexpression in multidrug resistance in cancer chemotherapy.
Biochemical Society transactions 2003;31(Pt 6):1372-7.
2003: Paul J Thornalley
Glyoxalase I--structure, function and a critical role in the enzymatic defence against glycation.
Biochemical Society transactions 2003;31(Pt 6):1343-8.
2003: Paul J Thornalley
The enzymatic defence against glycation in health, disease and therapeutics: a symposium to examine the concept.
Biochemical Society transactions 2003;31(Pt 6):1341-2.
2003: Naila Ahmed; Paul J Thornalley; Jens Dawczynski; Sybille Franke; Jürgen Strobel; Günter Stein; George M Haik
Methylglyoxal-derived hydroimidazolone advanced glycation end-products of human lens proteins.
Investigative ophthalmology & visual science 2003;44(12):5287-92.
2003: Paul J Thornalley
Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts.
Archives of biochemistry and biophysics 2003;419(1):31-40.
2003: Paul J Thornalley; Sinan Battah; Naila Ahmed; Nikolaos Karachalias; Stamatina Agalou; Roya Babaei-Jadidi; Anne Dawnay
Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry.
The Biochemical journal 2003;375(Pt 3):581-92.
2003: Naila Ahmed; Sinan Battah; Nikolaos Karachalias; Roya Babaei-Jadidi; Margit Horányi; Klára Baróti; Susan Hollan; Paul J Thornalley
Increased formation of methylglyoxal and protein glycation, oxidation and nitrosation in triosephosphate isomerase deficiency.
Biochimica et biophysica acta 2003;1639(2):121-32.
2003: Roya Babaei-Jadidi; Nikolaos Karachalias; Naila Ahmed; Sinan Battah; Paul J Thornalley
Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine.
Diabetes 2003;52(8):2110-20.
2003: Bente K Kilhovd; Ida Giardino; Peter A Torjesen; K I Birkeland; Tore J Berg; Paul J Thornalley; Michael Brownlee; Kristian F Hanssen
Increased serum levels of the specific AGE-compound methylglyoxal-derived hydroimidazolone in patients with type 2 diabetes.
Metabolism: clinical and experimental 2003;52(2):163-7.
2002: Berthil H C M T Prinsen; George A Kaysen; Leo W J Klomp; Jose de Boer; Hugh Barrett; Paul J Thornalley; Sinan Battah; Ruud Berger; ton rabelink; Monique G M de Sain-Van Der Velden
Idiopathic hypoalbuminemia explained by reduced synthesis rate and an increased catabolic rate.
Clinical biochemistry 2002;35(7):545-53.
2002: Naila Ahmed; Paul J Thornalley
Chromatographic assay of glycation adducts in human serum albumin glycated in vitro by derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and intrinsic fluorescence.
The Biochemical journal 2002;364(Pt 1):15-24.
2002: Naila Ahmed; Ognian K Argirov; Harjit S Minhas; Carlos A A Cordeiro; Paul J Thornalley
Assay of advanced glycation endproducts (AGEs): surveying AGEs by chromatographic assay with derivatization by 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and application to Nepsilon-carboxymethyl-lysine- and Nepsilon-(1-carboxyethyl)lysine-modified albumin.
The Biochemical journal 2002;364(Pt 1):1-14.
2002: Paul J Thornalley
Isothiocyanates: mechanism of cancer chemopreventive action.
Anti-cancer drugs 2002;13(4):331-8.
2002: Paul J Thornalley
Glycation in diabetic neuropathy: characteristics, consequences, causes, and therapeutic options.
International review of neurobiology 2002;50():37-57.
2002: Paul J Thornalley
Methods for studying the binding of advanced glycated proteins to receptors for advanced glycation endproducts (AGE receptors).
Methods in molecular biology (Clifton, N.J.) 2002;196():49-62.
2001: Paul J Thornalley; I Jahan; R Ng
Suppression of the accumulation of triosephosphates and increased formation of methylglyoxal in human red blood cells during hyperglycaemia by thiamine in vitro.
Journal of biochemistry 2001;129(4):543-9.
2001: K Xu; Paul J Thornalley
Signal transduction activated by the cancer chemopreventive isothiocyanates: cleavage of BID protein, tyrosine phosphorylation and activation of JNK.
British journal of cancer 2001;84(5):670-3.
2001: K Xu; Paul J Thornalley
Involvement of glutathione metabolism in the cytotoxicity of the phenethyl isothiocyanate and its cysteine conjugate to human leukaemia cells in vitro.
Biochemical pharmacology 2001;61(2):165-77.
2000: Paul J Thornalley; Mariana D Argirova; Naila Ahmed; V M Mann; Ognian K Argirov; Anne Dawnay
Mass spectrometric monitoring of albumin in uremia.
Kidney international 2000;58(5):2228-34.
2000: K Xu; Paul J Thornalley
Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro.
Biochemical pharmacology 2000;60(2):221-31.
2000: Paul J Thornalley; A Yurek-George; Ognian K Argirov
Kinetics and mechanism of the reaction of aminoguanidine with the alpha-oxoaldehydes glyoxal, methylglyoxal, and 3-deoxyglucosone under physiological conditions.
Biochemical pharmacology 2000;60(1):55-65.
2000: K Xu; Paul J Thornalley
Antitumour activity of sphingoid base adducts of phenethyl isothiocyanate.
Bioorganic & medicinal chemistry letters 2000;10(1):53-4.
1999: Paul J Thornalley; A Langborg; Harjit S Minhas
Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose.
The Biochemical journal 1999;344 Pt 1():109-16.
1999: EA Abordo; Harjit S Minhas; Paul J Thornalley
Accumulation of alpha-oxoaldehydes during oxidative stress: a role in cytotoxicity.
Biochemical pharmacology 1999;58(4):641-8.
1999: Paul J Thornalley; Harjit S Minhas
Rapid hydrolysis and slow alpha,beta-dicarbonyl cleavage of an agent proposed to cleave glucose-derived protein cross-links.
Biochemical pharmacology 1999;57(3):303-7.
1998: Ulf J Eriksson; Parri Wentzel; Harjit S Minhas; Paul J Thornalley
Teratogenicity of 3-deoxyglucosone and diabetic embryopathy.
Diabetes 1998;47(12):1960-6.
1998: Paul J Thornalley
Cell activation by glycated proteins. AGE receptors, receptor recognition factors and functional classification of AGEs.
Cellular and molecular biology (Noisy-le-Grand, France) 1998;44(7):1013-23.
1998: Paul J Thornalley
Glutathione-dependent detoxification of alpha-oxoaldehydes by the glyoxalase system: involvement in disease mechanisms and antiproliferative activity of glyoxalase I inhibitors.
Chemico-biological interactions 1998;111-112():137-51.
1998: M Shinohara; Paul J Thornalley; Ida Giardino; Paul J Beisswenger; Suzanne R Thorpe; JM Onorato; Michael Brownlee
Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis.
The Journal of clinical investigation 1998;101(5):1142-7.
1997: EA Abordo; Paul J Thornalley
Synthesis and secretion of tumour necrosis factor-alpha by human monocytic THP-1 cells and chemotaxis induced by human serum albumin derivatives modified with methylglyoxal and glucose-derived advanced glycation endproducts.
Immunology letters 1997;58(3):139-47.
1997: L Webster; EA Abordo; Paul J Thornalley; G Astrid Limb
Induction of TNF alpha and IL-1 beta mRNA in monocytes by methylglyoxal- and advanced glycated endproduct-modified human serum albumin.
Biochemical Society transactions 1997;25(2):250S.
1997: M E Westwood; Ognian K Argirov; EA Abordo; Paul J Thornalley
Methylglyoxal-modified arginine residues--a signal for receptor-mediated endocytosis and degradation of proteins by monocytic THP-1 cells.
Biochimica et biophysica acta 1997;1356(1):84-94.
1996: Paul J Thornalley; A C McLellan; T W Lo; J Benn; Peter H Sönksen
Negative association between erythrocyte reduced glutathione concentration and diabetic complications.
Clinical science (London, England : 1979) 1996;91(5):575-82.
1996: EA Abordo; M E Westwood; Paul J Thornalley
Synthesis and secretion of macrophage colony stimulating factor by mature human monocytes and human monocytic THP-1 cells induced by human serum albumin derivatives modified with methylglyoxal and glucose-derived advanced glycation endproducts.
Immunology letters 1996;53(1):7-13.
1996: Paul J Thornalley; M J Ladan; S J Ridgway; Y Kang
Antitumor activity of S-(p-bromobenzyl)glutathione diesters in vitro: a structure-activity study.
Journal of medicinal chemistry 1996;39(17):3409-11.
1996: Paul J Thornalley
Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification--a role in pathogenesis and antiproliferative chemotherapy.
General pharmacology 1996;27(4):565-73.
1996: Paul J Thornalley; L G Edwards; Y Kang; C Wyatt; N Davies; M J Ladan; J Double
Antitumour activity of S-p-bromobenzylglutathione cyclopentyl diester in vitro and in vivo. Inhibition of glyoxalase I and induction of apoptosis.
Biochemical pharmacology 1996;51(10):1365-72.
1996: Y Kang; L G Edwards; Paul J Thornalley
Effect of methylglyoxal on human leukaemia 60 cell growth: modification of DNA G1 growth arrest and induction of apoptosis.
Leukemia research 1996;20(5):397-405.
1996: M E Westwood; Paul J Thornalley
Induction of synthesis and secretion of interleukin 1 beta in the human monocytic THP-1 cells by human serum albumins modified with methylglyoxal and advanced glycation endproducts.
Immunology letters 1996;50(1-2):17-21.
1996: Adetola Adesida; L G Edwards; Paul J Thornalley
Inhibition of human leukaemia 60 cell growth by mercapturic acid metabolites of phenylethyl isothiocyanate.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(4):385-92.
1996: L G Edwards; Adetola Adesida; Paul J Thornalley
Inhibition of human leukaemia 60 cell growth by S-D-lactoylglutathione in vitro. Mediation by metabolism to N-D-lactoylcysteine and induction of apoptosis.
Leukemia research 1996;20(1):17-26.
1995: Harjit S Minhas; Paul J Thornalley
Reduced glutathione esters--antidotes to toxicity. Cytotoxicity induced by hydrogen peroxide, 1-chloro-2,4-dinitrobenzene, and menadione in murine P388D1 macrophages in vitro.
Journal of biochemical toxicology 1995;10(5):245-250.
1995: Paul J Thornalley
Advances in glyoxalase research. Glyoxalase expression in malignancy, anti-proliferative effects of methylglyoxal, glyoxalase I inhibitor diesters and S-D-lactoylglutathione, and methylglyoxal-modified protein binding and endocytosis by the advanced glycation endproduct receptor.
Critical reviews in oncology/hematology 1995;20(1-2):99-128.
1995: M E Westwood; Paul J Thornalley
Molecular characteristics of methylglyoxal-modified bovine and human serum albumins. Comparison with glucose-derived advanced glycation endproduct-modified serum albumins.
Journal of protein chemistry 1995;14(5):359-72.
1995: Harjit S Minhas; Paul J Thornalley
Comparison of the delivery of reduced glutathione into P388D1 cells by reduced glutathione and its mono- and diethyl ester derivatives.
Biochemical pharmacology 1995;49(10):1475-82.
1995: Paul J Thornalley; M Westwood; T W Lo; A C McLellan
Formation of methylglyoxal-modified proteins in vitro and in vivo and their involvement in AGE-related processes.
Contributions to nephrology 1995;112():24-31.
1994: T W Lo; M E Westwood; A C McLellan; T Selwood; Paul J Thornalley
Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with N alpha-acetylarginine, N alpha-acetylcysteine, and N alpha-acetyllysine, and bovine serum albumin.
The Journal of biological chemistry 1994;269(51):32299-305.
1994: M E Westwood; A C McLellan; Paul J Thornalley
Receptor-mediated endocytic uptake of methylglyoxal-modified serum albumin. Competition with advanced glycation end product-modified serum albumin at the advanced glycation end product receptor.
The Journal of biological chemistry 1994;269(51):32293-8.
1994: T W Lo; T Selwood; Paul J Thornalley
The reaction of methylglyoxal with aminoguanidine under physiological conditions and prevention of methylglyoxal binding to plasma proteins.
Biochemical pharmacology 1994;48(10):1865-70.
1994: G M Haik; T W Lo; Paul J Thornalley
Methylglyoxal concentration and glyoxalase activities in the human lens.
Experimental eye research 1994;59(4):497-500.
1994: L G Edwards; Paul J Thornalley
Prevention of S-D-lactoylglutathione-induced inhibition of human leukaemia 60 cell growth by uridine.
Leukemia research 1994;18(9):717-22.
1994: A C McLellan; Paul J Thornalley; J Benn; P H Sonksen
Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications.
Clinical science (London, England : 1979) 1994;87(1):21-9.
1994: Paul J Thornalley; M Strath; R J Wilson
Antimalarial activity in vitro of the glyoxalase I inhibitor diester, S-p-bromobenzylglutathione diethyl ester.
Biochemical pharmacology 1994;47(2):418-20.
1993: S A Phillips; D Mirrlees; Paul J Thornalley
Modification of the glyoxalase system in streptozotocin-induced diabetic rats. Effect of the aldose reductase inhibitor Statil.
Biochemical pharmacology 1993;46(5):805-11.
1993: A C McLellan; S A Phillips; Paul J Thornalley
The assay of S-D-lactoylglutathione in biological systems.
Analytical biochemistry 1993;211(1):37-43.
1993: R E Allen; T W Lo; Paul J Thornalley
Purification and characterisation of glyoxalase II from human red blood cells.
European journal of biochemistry / FEBS 1993;213(3):1261-7.
1993: F M Ayoub; R E Allen; Paul J Thornalley
Inhibition of proliferation of human leukaemia 60 cells by methylglyoxal in vitro.
Leukemia research 1993;17(5):397-401.
1993: R E Allen; T W Lo; Paul J Thornalley
Inhibitors of glyoxalase I: design, synthesis, inhibitory characteristics and biological evaluation.
Biochemical Society transactions 1993;21(2):535-40.
1993: Paul J Thornalley
Modification of the glyoxalase system in disease processes and prospects for therapeutic strategies.
Biochemical Society transactions 1993;21(2):531-4.
1993: A C McLellan; Paul J Thornalley; J Benn; P H Sonksen
Population genetics of human glyoxalases and the development of diabetic complications.
Biochemical Society transactions 1993;21(2):172S.
1993: R E Allen; Paul J Thornalley
Simple chromatographic methods for the purification of human red blood cell glyoxalase I and glyoxalase II to homogeneity.
Biochemical Society transactions 1993;21(2):171S.
1993: T Selwood; Paul J Thornalley
Binding of methylglyoxal to albumin and formation of fluorescent adducts. Inhibition by arginine, N-alpha-acetylarginine and aminoguanidine.
Biochemical Society transactions 1993;21(2):170S.
1993: M E Reeves; Paul J Thornalley
The hydrolysis of S-D-lactoylglutathione.
Biochemical Society transactions 1993;21(2):169S.
1993: F M Ayoub; R E Allen; Paul J Thornalley
Inhibition of proliferation of human leukaemia 60 cells by methylglyoxal in vitro.
Biochemical Society transactions 1993;21(2):168S.
1993: F M Ayoub; M A Zaman; Paul J Thornalley; J R Masters
Glyoxalase activity in human tumour cell lines in vitro.
Biochemical Society transactions 1993;21(2):167S.
1993: L G Edwards; J D Clelland; Paul J Thornalley
Mechanism of the inhibition of growth of human leukaemia 60 cells by S-D-lactoylglutathione.
Biochemical Society transactions 1993;21(2):166S.
1993: J D Clelland; L G Edwards; R E Allen; Paul J Thornalley
Inhibition of growth of human leukaemia 60 cells by S-2-hydroxyacylglutathione derivatives.
Biochemical Society transactions 1993;21(2):165S.
1993: A C McLellan; S A Phillips; Paul J Thornalley
The assay of S-D-lactoylglutathione in biological systems.
Biochemical Society transactions 1993;21(2):164S.
1993: S A Phillips; Paul J Thornalley
Formation of methylglyoxal and D-lactate in human red blood cells in vitro.
Biochemical Society transactions 1993;21(2):163S.
1993: R E Allen; Paul J Thornalley
The effect of S-D-lactoylglutathione on the movement of neutrophils.
Biochemical Society transactions 1993;21(2):161S.
1993: J D Clellan; Paul J Thornalley
The potentiation of GTP-dependent assembly of microtubules by S-D-lactoylglutathione.
Biochemical Society transactions 1993;21(2):160S.
1993: T W Lo; Paul J Thornalley
Inhibition of human leukaemia 60 cell growth by diethyl esterification of the glyoxalase II inhibitor S-p-nitrobenzoxycarbonylglutathione in vitro.
Biochemical Society transactions 1993;21(2):159S.
1993: A C McLellan; Paul J Thornalley; J Benn; P H Sonksen
Modification of the glyoxalase system in clinical diabetes mellitus.
Biochemical Society transactions 1993;21(2):158S.
1993: R E Allen; T W Lo; Paul J Thornalley
A simplified method for the purification of human red blood cell glyoxalase. I. Characteristics, immunoblotting, and inhibitor studies.
Journal of protein chemistry 1993;12(2):111-9.
1993: L Edwards; J D Clelland; Paul J Thornalley
Characteristics of the inhibition of human promyelocytic leukaemia HL60 cell growth by S-D-lactoylglutathione in vitro.
Leukemia research 1993;17(4):305-10.
1993: S A Phillips; Paul J Thornalley
The formation of methylglyoxal from triose phosphates. Investigation using a specific assay for methylglyoxal.
European journal of biochemistry / FEBS 1993;212(1):101-5.
1993: F Ayoub; M Zaman; Paul J Thornalley; J Masters
Glyoxalase activities in human tumour cell lines in vitro.
Anticancer research 1993;13(1):151-5.
1993: P R Smith; H H Somani; Paul J Thornalley; J Benn; P H Sonksen
Evidence against the formation of 2-amino-6-(2-formyl-5-hydroxymethyl-pyrrol-1-yl)-hexanoic acid ('pyrraline') as an early-stage product or advanced glycation end product in non-enzymic protein glycation.
Clinical science (London, England : 1979) 1993;84(1):87-93.
1993: Paul J Thornalley
The glyoxalase system in health and disease.
Molecular aspects of medicine 1993;14(4):287-371.
1992: P R Smith; Paul J Thornalley
Mechanism of the degradation of non-enzymatically glycated proteins under physiological conditions. Studies with the model fructosamine, N epsilon-(1-deoxy-D-fructos-1-yl)hippuryl-lysine.
European journal of biochemistry / FEBS 1992;210(3):729-39.
1992: T W Lo; Paul J Thornalley
Inhibition of proliferation of human leukaemia 60 cells by diethyl esters of glyoxalase inhibitors in vitro.
Biochemical pharmacology 1992;44(12):2357-63.
1992: J D Clelland; R E Allen; Paul J Thornalley
Inhibition of growth of human leukaemia 60 cells by S-2-hydroxyacylglutathiones and monoethyl ester derivatives.
Biochemical pharmacology 1992;44(10):1953-9.
1992: P R Smith; Paul J Thornalley
Influence of pH and phosphate ions on the kinetics of enolisation and degradation of fructosamines. Studies with the model fructosamine, N epsilon-1-deoxy-D-fructos-1-yl-hippuryl-lysine.
Biochemistry international 1992;28(3):429-39.
1992: A C McLellan; S A Phillips; Paul J Thornalley
The assay of methylglyoxal in biological systems by derivatization with 1,2-diamino-4,5-dimethoxybenzene.
Analytical biochemistry 1992;206(1):17-23.
1992: A C McLellan; S A Phillips; Paul J Thornalley
Fluorimetric assay of D-lactate.
Analytical biochemistry 1992;206(1):12-6.
1992: A C McLellan; Paul J Thornalley
Sample storage conditions for the assay of glyoxalase activities in whole blood samples.
Annals of clinical biochemistry 1992;29 ( Pt 2)():222-3.
1992: P R Smith; Paul J Thornalley
Preparation and characterisation of N epsilon-(1-deoxy-D-fructos-1-yl)hippuryl-lysine.
Carbohydrate research 1992;223():293-8.
1992: A C McLellan; Paul J Thornalley
Electrophoretic analysis of isoforms of glyoxalase II in clinical blood samples.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1992;30(1):7-10.
1991: A C McLellan; Paul J Thornalley
Optimisation of non-denaturing polyacrylamide gel electrophoretic analysis of glyoxalase I phenotypes in clinical blood samples.
Clinica chimica acta; international journal of clinical chemistry 1991;204(1-3):137-43.
1991: Paul J Thornalley
Population genetics of human glyoxalases.
Heredity 1991;67 ( Pt 2)():139-42.
1990: Paul J Thornalley
The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life.
The Biochemical journal 1990;269(1):1-11.
1989: Paul J Thornalley; N I Hooper; P E Jennings; CM Florkowski; A F Jones; Joseph Lunec; Anthony H Barnett
The human red blood cell glyoxalase system in diabetes mellitus.
Diabetes research and clinical practice 1989;7(2):115-20.
1989: A C McLellan; Paul J Thornalley
Glyoxalase activity in human red blood cells fractioned by age.
Mechanisms of ageing and development 1989;48(1):63-71.
1988: Paul J Thornalley
Modification of the glyoxalase system in human red blood cells by glucose in vitro.
The Biochemical journal 1988;254(3):751-5.
1988: N I Hooper; Michael J Tisdale; Paul J Thornalley
Modification of the glyoxalase system in human HL60 promyelocytic leukaemia cells during differentiation to neutrophils in vitro.
Biochimica et biophysica acta 1988;966(3):362-9.
1988: Paul J Thornalley; Michael J Tisdale
Inhibition of proliferation of human promyelocytic leukaemia HL60 cells by S-D-lactoylglutathione in vitro.
Leukemia research 1988;12(11-12):897-904.
1987: Paul J Thornalley; P Bellavite
Modification of the glyoxalase system during the functional activation of human neutrophils.
Biochimica et biophysica acta 1987;931(2):120-9.
1987: A F Jones; J W Winkles; Paul J Thornalley; Joseph Lunec; P E Jennings; Anthony H Barnett
Inhibitory effect of superoxide dismutase on fructosamine assay.
Clinical chemistry 1987;33(1):147-9.
1987: N I Hooper; Michael J Tisdale; Paul J Thornalley
Glyoxalase activity during differentiation of human leukaemia cells in vitro.
Leukemia research 1987;11(12):1141-8.
1986: Paul J Thornalley; William H Bannister; J V Bannister
Reduction of oxygen by NADH/NADH dehydrogenase in the presence of adriamycin.
Free radical research communications 1986;2(3):163-71.