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Montserrat Borrell

Research Profile

Anatomy

Thrombosis

Geographic Areas

Spain

Concepts & Ideas

Chemicals & Drugs

Disorders

Physiology

Procedures

Blood Coagulation Tests

Phenomena

Partial Thromboplastin Time

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Publications

TOP 3
G Athanasiadis; Montserrat Borrell; Alfonso Buil; A Hamsten; Mark Lathrop; Maria Sabater-Lleal; Juan Carlos Souto; H Watkins; Laura A Almasy; José Manuel Soria
Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain.
Maria Sabater-Lleal; Angela Silveira; Juan Carlos Souto; Laura Almasy; Montserrat Borrell; Maria Bruzelius; Alfonso Buil; Per Eriksson; Lasse Folkersen; Anders Hamsten; Angel Martinez-Perez; Jacob Odeberg; José Manuel Soria
A genome-wide association study identifies KNG1 as a genetic determinant of plasma factor XI Level and activated partial thromboplastin time.
Salvador Rico; Rosa Maria Antonijoan; Ignasi Gich; Montserrat Borrell; Jordi Fontcuberta; Manuel Monreal; Javier Martinez-Gonzalez; Manel J Barbanoj
Safety assessment and pharmacodynamics of a novel ultra low molecular weight heparin (RO-14) in healthy volunteers--a first-time-in-human single ascending dose study.

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All Publications

2013: G Athanasiadis; Montserrat Borrell; Alfonso Buil; A Hamsten; Mark Lathrop; Maria Sabater-Lleal; Juan Carlos Souto; H Watkins; Laura A Almasy; José Manuel Soria
Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain.
Journal of thrombosis and haemostasis : JTH 2013;11(3):521-8.
2012: Maria Sabater-Lleal; Angela Silveira; Juan Carlos Souto; Laura Almasy; Montserrat Borrell; Maria Bruzelius; Alfonso Buil; Per Eriksson; Lasse Folkersen; Anders Hamsten; Angel Martinez-Perez; Jacob Odeberg; José Manuel Soria
A genome-wide association study identifies KNG1 as a genetic determinant of plasma factor XI Level and activated partial thromboplastin time.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(8):2008-16.
2011: Salvador Rico; Rosa Maria Antonijoan; Ignasi Gich; Montserrat Borrell; Jordi Fontcuberta; Manuel Monreal; Javier Martinez-Gonzalez; Manel J Barbanoj
Safety assessment and pharmacodynamics of a novel ultra low molecular weight heparin (RO-14) in healthy volunteers--a first-time-in-human single ascending dose study.
Thrombosis research 2011;127(4):292-8.
2010: Joan Martí-Fàbregas; Montserrat Borrell; Yolanda Silva; Raquel Delgado-Mederos; Sergi Martínez-Ramírez; M de Juan Delago; Isabel Tirado; Aída Alejaldre; Rebeca Marín; Josep-Lluis Martí-Vilalta; Jordi Fontcuberta
Hemostatic proteins and their association with hematoma growth in patients with acute intracerebral hemorrhage.
Stroke; a journal of cerebral circulation 2010;41(12):2976-8.
2009: Rosa Antonijoan; S Rico; J Martínez-González; Montserrat Borrell; D Valcarcel; Jordi Fontcuberta; Manel J Barbanoj
Comparative pharmacodynamic time-course of bemiparin and enoxaparin in healthy volunteers.
International journal of clinical pharmacology and therapeutics 2009;47(12):726-32.
2008: Maria Sabater-Lleal; Alfonso Buil; Juan Carlos Souto; Laura Alamsy; Montserrat Borrell; Mark Lathrop; John C Blangero; Jordi Fontcuberta; José Manuel Soria
A genome-wide exploration suggests an oligogenic model of inheritance for the TAFI activity and its antigen levels.
Human genetics 2008;124(1):81-8.
2008: Joan Martí-Fàbregas; Montserrat Borrell; Dolores Cocho; Sergi Martínez-Ramírez; Mercè Martínez-Corral; Jordi Fontcuberta; Josep-Lluis Martí-Vilalta
Change in hemostatic markers after recombinant tissue-type plasminogen activator is not associated with the chance of recanalization.
Stroke; a journal of cerebral circulation 2008;39(1):234-6.
2007: Amparo Santamaría; Arturo Oliver; Montserrat Borrell; Robert Belvís; Joan Martí-Fábregas; José Mateo; Jordi Fontcuberta
Higher risk of ischaemic stroke associated with factor XI levels in dyslipidaemic patients.
International journal of clinical practice 2007;61(11):1819-23.
2007: Robert Belvís; Amparo Santamaría; Joan Martí-Fàbregas; Rubén Leta; Dolores Cocho; Montserrat Borrell; Jordi Fontcuberta; Josep-Lluis Martí-Vilalta
Patent foramen ovale and prothrombotic markers in young stroke patients.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2007;18(6):537-42.
2007: A Santamaría; Montserrat Borrell; J Mateo; C Vallve; J Fontcuberta
What is the clinical impact of low plasminogen activator inhibitor-1 (PAI-1) activity? A case report and study of the incidence of low PAI-1 antigen in a healthy population.
Journal of thrombosis and haemostasis : JTH 2007;5(7):1565-6.
2007: Dolors Llobet; Montserrat Borrell; Ll Vila; Cristina Vallvé; Rosa Felices; Jordi Fontcuberta
An acquired inhibitor that produced a delay of fibrinopeptide B release in an asymptomatic patient.
Haematologica 2007;92(2):e17-9.
2006: Mercedes Rigla; Ana María Wägner; Montserrat Borrell; José Mateo; Jordi Foncuberta; Alberto de Leiva; Jordi Ordóñez-Llanos; Antonio Pérez
Postprandial thrombin activatable fibrinolysis inhibitor and markers of endothelial dysfunction in type 2 diabetic patients.
Metabolism: clinical and experimental 2006;55(11):1437-42.
2006: Robert Belvís; Amparo Santamaría; Joan Martí-Fàbregas; Dolores Cocho; Montserrat Borrell; Jordi Fontcuberta; Josep-Lluis Martí-Vilalta
Diagnostic yield of prothrombotic state studies in cryptogenic stroke.
Acta neurologica Scandinavica 2006;114(4):250-3.
2006: Dolores Cocho; Montserrat Borrell; Joan Martí-Fàbregas; Joan Montaner; Mar Castellanos; Yolanda Bravo; Laura Molina-Porcel; Robert Belvís; Jordi Díaz-Manera; Alejandro Martínez-Domeño; María Martínez-Lage; Mónica Millán; Jordi Fontcuberta; Josep-Lluis Martí-Vilalta
Pretreatment hemostatic markers of symptomatic intracerebral hemorrhage in patients treated with tissue plasminogen activator.
Stroke; a journal of cerebral circulation 2006;37(4):996-9.
2006: José Mateo; Isabel Badell; Ruth Forner; Montserrat Borrell; Eduardo F Tizzano; Jordi Fontcuberta
Successful suppression using Rituximab of a factor VIII inhibitor in a boy with severe congenital haemophilia: an example of a significant decrease of treatment costs.
Thrombosis and haemostasis 2006;95(2):386-7.
2005: Joan Martí-Fàbregas; Montserrat Borrell; Dolores Cocho; Robert Belvís; Mar Castellanos; J Montaner; Javier Pagonabarraga; Aitziber Aleu; Laura Molina-Porcel; Jordi Díaz-Manera; Yolanda Bravo; J Alvarez-Sabín; A Dávalos; Jordi Fontcuberta; Josep-Lluis Martí-Vilalta
Hemostatic markers of recanalization in patients with ischemic stroke treated with rt-PA.
Neurology 2005;65(3):366-70.
2005: Laura A Almasy; José Manuel Soria; Juan Carlos Souto; Diane M Warren; Alfonso Buil; Montserrat Borrell; Xavier Muñoz; Núria Sala; Mark Lathrop; Jordi Fontcuberta; John C Blangero
A locus on chromosome 2 influences levels of tissue factor pathway inhibitor: results from the GAIT study.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(7):1489-92.
2005: Isabel Tirado; José Mateo; José Manuel Soria; Arturo Oliver; Elisabeth Martínez-Sánchez; Cristina Vallvé; Montserrat Borrell; Teresa Urrutia; Jordi Fontcuberta
The ABO blood group genotype and factor VIII levels as independent risk factors for venous thromboembolism.
Thrombosis and haemostasis 2005;93(3):468-74.
2004: Amparo Santamaría; Montserrat Borrell; Arturo Oliver; Rosa Ortín; Ruth Forner; Inmaculada Coll; José Mateo; Juan Carlos Souto; Jordi Fontcuberta
Association of functional thrombin-activatable fibrinolysis inhibitor (TAFI) with conventional cardiovascular risk factors and its correlation with other hemostatic factors in a Spanish population.
American journal of hematology 2004;76(4):348-52.
2004: Amparo Santamaría; Antonio Martínez-Rubio; Montserrat Borrell; José Mateo; Rosa Ortín; Jordi Fontcuberta
Risk of acute coronary artery disease associated with functional thrombin activatable fibrinolysis inhibitor plasma level.
Haematologica 2004;89(7):880-1.
2004: Isabel Tirado; José Manuel Soria; José Mateo; Arturo Oliver; Juan Carlos Souto; Amparo Santamaria; Rosa Felices; Montserrat Borrell; Jordi Fontcuberta
Association after linkage analysis indicates that homozygosity for the 46C-->T polymorphism in the F12 gene is a genetic risk factor for venous thrombosis.
Thrombosis and haemostasis 2004;91(5):899-904.
2003: Amparo Santamaría; Arturo Oliver; Montserrat Borrell; José Mateo; R Belvis; Joan Martí-Fábregas; Rosa Ortín; Isabel Tirado; Juan Carlos Souto; Jordi Fontcuberta
Risk of ischemic stroke associated with functional thrombin-activatable fibrinolysis inhibitor plasma levels.
Stroke; a journal of cerebral circulation 2003;34(10):2387-91.
2003: Laura A Almasy; José Manuel Soria; Juan Carlos Souto; Immaculada Coll; Delphine Bacq; Alexandra Faure; José Mateo; Montserrat Borrell; Xavier Muñoz; Núria Sala; William H Stone; Mark Lathrop; Jordi Fontcuberta; John C Blangero
A quantitative trait locus influencing free plasma protein S levels on human chromosome 1q: results from the Genetic Analysis of Idiopathic Thrombophilia (GAIT) project.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(3):508-11.
2003: José Manuel Soria; Laura A Almasy; Juan Carlos Souto; Alfonso Buil; Elisabeth Martinez-Sanchez; José Mateo; Montserrat Borrell; William H Stone; Mark Lathrop; Jordi Fontcuberta; John C Blangero
A new locus on chromosome 18 that influences normal variation in activated protein C resistance phenotype and factor VIII activity and its relation to thrombosis susceptibility.
Blood 2003;101(1):163-7.
2002: Montserrat Borrell; Dolors Llobet; Rosa Ortín; Rosa Felices; Cristina Vallvé; José Mateo; Juan Carlos Souto; Jordi Fontcuberta
Thromboplastin-thrombomodulin-mediated time: a new global test sensitive to protein S deficiency and increased levels of factors II, V, VII and X.
Haematologica 2002;87(4):415-9.
2002: José Manuel Soria; Laura A Almasy; Juan Carlos Souto; Delphine Bacq; Alfonso Buil; Alexandra Faure; Elisabeth Martínez-Marchán; José Mateo; Montserrat Borrell; William Stone; Mark Lathrop; Jordi Fontcuberta; John C Blangero
A quantitative-trait locus in the human factor XII gene influences both plasma factor XII levels and susceptibility to thrombotic disease.
American journal of human genetics 2002;70(3):567-74.
2002: Juan Carlos Souto; Laura A Almasy; Montserrat Borrell; William H Stone; Francisco Blanco-Vaca; José Manuel Soria; John C Blangero; Jordi Fontcuberta
Thromboplastin-thrombomodulin-mediated time and serum folate levels are genetically correlated with the risk of thromboembolic disease: results from the GAIT project.
Thrombosis and haemostasis 2002;87(1):68-73.
2001: Isabel Tirado; José Mateo; José Manuel Soria; Arturo Oliver; Montserrat Borrell; Immaculada Coll; Cristina Vallvé; Juan Carlos Souto; Elisabeth Martínez-Sánchez; Jordi Fontcuberta
Contribution of prothrombin 20210A allele and factor V Leiden mutation to thrombosis risk in thrombophilic families with other hemostatic deficiencies.
Haematologica 2001;86(11):1200-8.
2001: Amparo Santamaría; José Mateo; Arturo Oliver; B Menéndez; Juan Carlos Souto; Montserrat Borrell; José Manuel Soria; Isabel Tirado; Jordi Fontcuberta
Risk of thrombosis associated with oral contraceptives of women from 97 families with inherited thrombophilia: high risk of thrombosis in carriers of the G20210A mutation of the prothrombin gene.
Haematologica 2001;86(9):965-71.
2001: Juan Carlos Souto; Laura A Almasy; John C Blangero; William Stone; Montserrat Borrell; Teresa Urrutia; José Mateo; Jordi Fontcuberta
Genetic regulation of plasma levels of vitamin K-dependent proteins involved in hematostatis: results from the GAIT Project. Genetic Analysis of Idiopathic Thrombophilia.
Thrombosis and haemostasis 2001;85(1):88-92.
2000: Juan Carlos Souto; Laura A Almasy; Montserrat Borrell; Francisco Blanco-Vaca; José Mateo; José Manuel Soria; Immaculada Coll; Rosa Felices; William Stone; Jordi Fontcuberta; John C Blangero
Genetic susceptibility to thrombosis and its relationship to physiological risk factors: the GAIT study. Genetic Analysis of Idiopathic Thrombophilia.
American journal of human genetics 2000;67(6):1452-9.
2000: Juan Carlos Souto; Laura A Almasy; Eduardo Muñiz-Diaz; José Manuel Soria; Montserrat Borrell; L Bayén; José Mateo; Pedro Madoz; William Stone; John C Blangero; Jordi Fontcuberta
Functional effects of the ABO locus polymorphism on plasma levels of von Willebrand factor, factor VIII, and activated partial thromboplastin time.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(8):2024-8.
2000: Juan Carlos Souto; Laura A Almasy; Montserrat Borrell; M Garí; E Martínez; José Mateo; William H Stone; John C Blangero; Jordi Fontcuberta
Genetic determinants of hemostasis phenotypes in Spanish families.
Circulation 2000;101(13):1546-51.
2000: Yolanda Espinosa-Parrilla; M Morell; Montserrat Borrell; Juan Carlos Souto; Jordi Fontcuberta; Xavier Estivill; Núria Sala
Optimization of a simple and rapid single-strand conformation analysis for detection of mutations in the PROS1 gene: identification of seven novel mutations and three novel, apparently neutral, variants.
Human mutation 2000;15(5):463-73.
1999: Juan Carlos Souto; José Mateo; José Manuel Soria; Dolors Llobet; Immaculada Coll; Montserrat Borrell; Jordi Fontcuberta
Homozygotes for prothrombin gene 20210 A allele in a thrombophilic family without clinical manifestations of venous thromboembolism.
Haematologica 1999;84(7):627-32.
1999: Isabel Tirado; José Mateo; Arturo Oliver; Montserrat Borrell; Juan Carlos Souto; Jordi Fontcuberta
Patients with venous thromboembolism have a lower APC response than controls. Should this be regarded as a continuous risk factor for venous thrombosis?
Haematologica 1999;84(5):470-2.
1998: Juan Carlos Souto; Immaculada Coll; Dolors Llobet; Elisabeth del Río; Arturo Oliver; José Mateo; Montserrat Borrell; Jordi Fontcuberta
The prothrombin 20210A allele is the most prevalent genetic risk factor for venous thromboembolism in the Spanish population.
Thrombosis and haemostasis 1998;80(3):366-9.
1998: Montserrat Borrell; Montserrat Ponsà; Josep Egozcue; A Rubio; Montserrat Garcia
Chromosome abnormalities in peripheral blood lymphocytes from Macaca fascicularis and Erythrocebus patas (Cercopithecidae, Catarrhini) after X-ray irradiation.
Mutation research 1998;403(1-2):185-98.
1998: José Mateo; Arturo Oliver; Montserrat Borrell; Núria Sala; Jordi Fontcuberta
Increased risk of venous thrombosis in carriers of natural anticoagulant deficiencies. Results of the family studies of the Spanish Multicenter Study on Thrombophilia (EMET study).
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1998;9(1):71-8.
1997: Yolanda Espinosa-Parrilla; M Morell; Juan Carlos Souto; Montserrat Borrell; DAMIA HEINE; Isabel Tirado; V Volpini; Xavier Estivill; Núria Sala
Absence of linkage between type III protein S deficiency and the PROS1 and C4BP genes in families carrying the protein S Heerlen allele.
Blood 1997;89(8):2799-806.
1997: José Mateo; Arturo Oliver; Montserrat Borrell; Núria Sala; Jordi Fontcuberta
Laboratory evaluation and clinical characteristics of 2,132 consecutive unselected patients with venous thromboembolism--results of the Spanish Multicentric Study on Thrombophilia (EMET-Study).
Thrombosis and haemostasis 1997;77(3):444-51.
1997: A Altès; Juan Carlos Souto; José Mateo; Montserrat Borrell; Jordi Fontcuberta
Activated protein C resistance assay when applied in the general population.
American journal of obstetrics and gynecology 1997;176(2):358-9.
1995: Dolors Llobet; L Falkon; José Mateo; C Vallvé; E Martínez; J Fontcuberta; Montserrat Borrell
Low levels of tissue factor pathway inhibitor (TFPI) in two out of three members of a family with thrombophilia.
Thrombosis research 1995;80(5):413-8.
1995: Juan Carlos Souto; Montserrat Borrell; J Fontcuberta; M Roca
Antiphospholipid antibodies in inflammatory bowel disease.
Digestive diseases and sciences 1995;40(7):1524-5.
1995: Montserrat Borrell; M Garí; Immaculada Coll; C Vallvé; Isabel Tirado; J M Soria; Núria Sala; C Muñoz; Arturo Oliver; A García
Abnormal polymerization and normal binding of plasminogen and t-PA in three new dysfibrinogenaemias: Barcelona III and IV (gamma Arg 275-->His) and Villajoyosa (gamma Arg 275-->Cys).
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1995;6(3):198-206.
1994: J M Soria; J Fontcuberta; Montserrat Borrell; Xavier Estivill; Núria Sala
Two novel mutations in exon 5 of the protein C gene in two Spanish families with thrombophilia due to protein C deficiency.
Human molecular genetics 1994;3(7):1205-6.
1994: M Garí; L Falkon; T Urrutia; C Vallvé; Montserrat Borrell; J Fontcuberta
The influence of low protein S plasma levels in young women, on the definition of normal range.
Thrombosis research 1994;73(2):149-52.
1993: José Mateo; Rodrigo Martino; Montserrat Borrell; M Garí; F Casas; J Fontcuberta
Acquired factor VIII inhibitor preceding chronic lymphocytic leukemia.
Annals of hematology 1993;67(6):309-11.
1993: Juan Carlos Souto; M Garí; Montserrat Borrell; J Fontcuberta
[Absence of interaction between oral anticoagulants and influenza vaccine].
Medicina clínica 1993;101(16):637.
1993: J M Soria; J Fontcuberta; M Chillón; Montserrat Borrell; X Estivill; Núria Sala
Acceptor splice site mutation in the invariant AG of intron 5 of the protein C gene, causing type I protein C deficiency.
Human genetics 1993;92(5):506-8.
1993: M Montagud; I Montserrat; Arturo Oliver; J M Adelantado; José Mateo; Montserrat Borrell; J Fontcuberta
[Pregnancy and thrombophilia in women with congenital deficit of antithrombin III, protein C, protein S or plasminogen: analysis of 39 cases].
Medicina clínica 1993;100(6):201-4.
1992: J M Soria; I Ibáñez; J Fontcuberta; Montserrat Borrell; X Estivill; Núria Sala
[Polymorphism MI detected through the enzyme MspI in the study of congenital protein C deficiency].
Medicina clínica 1992;99(17):649-52.
1992: Montserrat Borrell; Núria Sala; C de Castellarnau; S Lopez; M Gari; J Fontcuberta
Immunoglobulin fractions isolated from patients with antiphospholipid antibodies prevent the inactivation of factor Va by activated protein C on human endothelial cells.
Thrombosis and haemostasis 1992;68(3):268-72.
1992: L Falkon; Montserrat Borrell; Núria Sala; J Felez; S Martín; E Grau; J Fontcuberta
Fibrinolytic abnormalities. A Spanish multicenter study ebt.I on 443 patients with venous thromboembolic disease.
Thrombosis research 1992;66(4):455-60.
1992: L Falkon; M Gari; I Montserrat; Montserrat Borrell; J Fontcuberta
Familial elevation of plasma histidine-rich glycoprotein. A case associated with recurrent venous thrombosis and high PAI-1 levels.
Thrombosis research 1992;66(2-3):265-70.
1992: L Falkon; M Garí; Montserrat Borrell; J Fontcuberta
The release of plasminogen activators (t-PA and u-PA) and plasminogen activator inhibitor (PAI-1) after venous stasis.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1992;3(1):33-8.
1992: J M Soria; J Fontcuberta; Montserrat Borrell; Xavier Estivill; Núria Sala
Protein C deficiency: identification of a novel two-base pair insertion and two point mutations in exon 7 of the protein C gene in Spanish families.
Human mutation 1992;1(5):428-31.
1990: I Zuazu-Jausoro; Montserrat Borrell; T Urrutia; Arturo Oliver; I Montserrat; José Mateo; L Ribera; J Fontcuberta
[Detection of thrombin-antithrombin complexes in hypercoagulability conditions. Analysis of 182 cases].
Sangre 1990;35(5):375-9.
1990: I Zuazu-Jausoro; Arturo Oliver; I Monserrat; Montserrat Borrell; M Garí; I Pich; E Grau; J Fontcuberta
[Importance of antiphosphatidylserine antibodies in patients with lupus anticoagulant. Analysis of 30 cases].
Medicina clínica 1990;95(6):210-3.
1990: Montserrat Borrell; L Vila; J Solá; Immaculada Coll; J Fontcuberta
Fibrinogen Barcelona II: a new case of A alpha 16 Arg----His substitution.
Haemostasis 1990;20(1):1-7.
1988: C de Castellarnau; I Pich; Montserrat Borrell; J Fontcuberta; Luis Cabero Roura; J Esteban-Altirriba
Serial measurements of a plasma prostacyclin inhibitor in a patient with recurrent abortions and lupus anticoagulant; a case report.
European journal of obstetrics, gynecology, and reproductive biology 1988;29(2):173-8.
1987: Núria Sala; E Muñiz; Montserrat Borrell; J Félez; J Fontcuberta
[Congenital protein C deficiency in patients with thromboembolic disease. Study of 4 Spanish families].
Medicina clínica 1987;88(15):569-73.
1987: Núria Sala; Montserrat Borrell; K A Bauer; S Viganò-D'Angelo; J Fontcuberta; J Félez; M L Rutllant
Dysfunctional activated protein C (PC Cádiz) in a patient with thrombotic disease.
Thrombosis and haemostasis 1987;57(2):183-6.
1987: Montserrat Borrell; L Vila; J Solá; Immaculada Coll; N Gómez; N González; M L Rutllant
Two cases of dysfibrinogenemia characterized by abnormal FPB release: fibrinogen Madrid I & II.
Thrombosis research 1987;45(5):591-9.
1985: Montserrat Borrell; C de Castellarnau
[Lupus-type anticoagulant].
Sangre 1985;30(4-C):803-11.
1983: C de Castellarnau; L Vila; M J Sancho; Montserrat Borrell; J Fontcuberta; M L Rutllant
Lupus anticoagulant, recurrent abortion, and prostacyclin production by cultured smooth muscle cells.
Lancet 1983;2(8359):1137-8.
1982: J Fontcuberta; Montserrat Borrell; J Felez; I Elez; M López; A Remacha; M L Rutllant
[Changes in fibrinolysis in liver cirrhosis].
Sangre 1982;27(4-B):727-36.