FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Adrian Thrasher

Research Profile

Procedures

Chemicals & Drugs

Living Beings

Disorders

Physiology

Anatomy

Devices

Gene Transfer Techniques

Genes & Molecular Sequences

Transgenes

Co-author Network

Publications

TOP 3
Emma Morris; Andrew Baker; Martin Gore; Adrian J Thrasher
Moving forward on shifting sands: ethical regulation of gene therapy clinical trials in the United kingdom.
Hannah Schachtner; Amy Sinclair; Steven G Thomas; Adrian J Thrasher; Milica Vukovic; Steve P Watson; Michael P Blundell; Simon D J Calaminus; Christian Gachet; Tessa L Holyoake; Gareth E Jones; Catherine Leon; Alison M Michie; James Monypenny; Laura M Machesky
Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane.
Giorgia Santilli; Adrian J Thrasher; John Anderson; Sandra Cantilena; Olesya Chayka; Marco D'Alicarnasso; Nourredine Himoudi; Daniel A Morgenstern; Katie Pearson; Izabela Piotrowska; Arturo Sala
Polyphenol E enhances the antitumor immune response in neuroblastoma by inactivating myeloid suppressor cells.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Adrian Thrasher (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Emma Morris; Andrew Baker; Martin Gore; Adrian J Thrasher
Moving forward on shifting sands: ethical regulation of gene therapy clinical trials in the United kingdom.
Molecular therapy : the journal of the American Society of Gene Therapy 2013;21(4):715-6.
2013: Hannah Schachtner; Amy Sinclair; Steven G Thomas; Adrian J Thrasher; Milica Vukovic; Steve P Watson; Michael P Blundell; Simon D J Calaminus; Christian Gachet; Tessa L Holyoake; Gareth E Jones; Catherine Leon; Alison M Michie; James Monypenny; Laura M Machesky
Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane.
Blood 2013;121(13):2542-52.
2013: Giorgia Santilli; Adrian J Thrasher; John Anderson; Sandra Cantilena; Olesya Chayka; Marco D'Alicarnasso; Nourredine Himoudi; Daniel A Morgenstern; Katie Pearson; Izabela Piotrowska; Arturo Sala
Polyphenol E enhances the antitumor immune response in neuroblastoma by inactivating myeloid suppressor cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(5):1116-25.
2013: Emad Moeendarbary; Dale A Moulding; Eleanor Stride; Adrian J Thrasher; Léo Valon; Marco Fritzsche; Andrew R Harris; L Mahadevan; Guillaume T Charras
The cytoplasm of living cells behaves as a poroelastic material.
Nature materials 2013;12(3):253-61.
2013: Christine Rivat; Neil J Sebire; Adrian J Thrasher; Maria Alonso-Ferrero; Michael P Blundell; Claire Booth; H Bobby Gaspar
SAP gene transfer restores cellular and humoral immune function in a murine model of X-linked lymphoproliferative disease.
Blood 2013;121(7):1073-6.
2013: H Bobby Gaspar; Sue Swift; Adrian J Thrasher
"Special exemptions": should they be put on trial?
Molecular therapy : the journal of the American Society of Gene Therapy 2013;21(2):261-2.
2013: Ali Nowrouzi; Emma Osejindu; Anna Paruzynski; Safia Reja; Terry P Roberts; Alaine Ruthe; Manfred Schmidt; Michael Themis; Faisal Al-Allaf; Robert Andrews; Anne Arens; Brian Bigger; Suzanne Mk Buckley; Wing T Cheung; Charles Coutelle; Niraja Dighe; Lisa Gregory; Maxine Holder; Tingting Li; Eugenio Montini; Robert F Newbold; Adrian J Thrasher; Christof von Kalle; Simon Waddington; Yoahe Wang; Xuegong Zhang; Mike Themis
The fetal mouse is a sensitive genotoxicity model that exposes lentiviral-associated mutagenesis resulting in liver oncogenesis.
Molecular therapy : the journal of the American Society of Gene Therapy 2013;21(2):324-37.
2013: Cédric Boucherie; Els Henckaerts; Sayandip Mukherjee; Jane C Sowden; Adrian J Thrasher; Robin R Ali
Brief report: self-organizing neuroepithelium from human pluripotent stem cells facilitates derivation of photoreceptors.
Stem cells (Dayton, Ohio) 2013;31(2):408-14.
2013: Dafni Moschidou; Sayandip Mukherjee; Adrian J Thrasher; Gemma N Jones; Anthony J Atala; Michael P Blundell; Paolo De Coppi; Nicholas M Fisk; Pascale V Guillot
Human mid-trimester amniotic fluid stem cells cultured under embryonic stem cell conditions with valproic acid acquire pluripotent characteristics.
Stem cells and development 2013;22(3):444-58.
2013: Austen J J Worth; Gerben Bouma; Guillaume T Charras; Giles O C Cory; Marco Fritzsche; Joao Metelo; Dale Moulding; Adrian J Thrasher; Bertrand Vernay; Siobhan O Burns
Disease-associated missense mutations in the EVH1 domain disrupt intrinsic WASp function causing dysregulated actin dynamics and impaired dendritic cell migration.
Blood 2013;121(1):72-84.
2012: Siobhan O Burns; James Curtis; Rainer Doffinger; Michael Eisenhut; Dinakantha S Kumararatne; Kin Mok; Vincent Plagnol; Adrian J Thrasher; Helen L Zenner; Sergey Nejentsev
LRBA gene deletion in a patient presenting with autoimmunity without hypogammaglobulinemia.
The Journal of allergy and clinical immunology 2012;130(6):1428-32.
2012: Helen E Chick; Christian Delles; Raffaele Fronza; Nicole M Kane; Robert A McDonald; Ali Nowrouzi; Manfred Schmidt; William C Sessa; Adrian J Thrasher; Raul Alba; Andrew H Baker
Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk.
Human gene therapy 2012;23(12):1247-57.
2012: Vincent Plagnol; Emma Stebbings; Adrian J Thrasher; Nicholas W Wood; Siobhan O Burns; James Curtis; Rainer Doffinger; Michael Epstein; Sofia Grigoriadou; Sophie Hambleton; Dinakantha Kumararatne; Kin Y Mok; Sergey Nejentsev
A robust model for read count data in exome sequencing experiments and implications for copy number variant calling.
Bioinformatics (Oxford, England) 2012;28(21):2747-54.
2012: Dafni Moschidou; Sayandip Mukherjee; Daniel Nettersheim; Beata Nowakowska; Anju Phoolchund; T Selvee Ramasamy; Hubert Schorle; Mark Sullivan; Adrian J Thrasher; Joris R Vermeesch; Hassan Abdulrazzak; James Adjaye; Anthony Atala; Michael P Blundell; Mara Cananzi; Paolo De Coppi; Katharina Drews; Nicholas M Fisk; Jennifer Frost; Gemma N Jones; Kenneth Lay; Gudrun Moore; Pascale V Guillot
Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(10):1953-67.
2012: Niek P van Til; Anna Villa; Trudi P Visser; Agnieszka Wabik; Barbara Cassani; Helen de Boer; Elena Fontana; Marshall Huston; Nomusa Mashamba; Pietro Luigi Poliani; Adrian J Thrasher; Fang Zhang; Gerard Wagemaker
Correction of murine Rag2 severe combined immunodeficiency by lentiviral gene therapy using a codon-optimized RAG2 therapeutic transgene.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(10):1968-80.
2012: Konstantina Kallinikou; David C Linch; Adrian J Thrasher; Michael J Watts; Fernando Anjos-Afonso; Michael P Blundell; Dominique Bonnet; Stuart J Ings; Kwee L Yong
Engraftment defect of cytokine-cultured adult human mobilized CD34(+) cells is related to reduced adhesion to bone marrow niche elements.
British journal of haematology 2012;158(6):778-87.
2012: Sean Knight; Uta Mueller-Kuller; Sha Sha; Michael N Antoniou; Marieke Bokhoven; Christian Brendel; Thomas Broughton; Mary Collins; Manuel Grez; Abhinav Gupta; Adrian J Thrasher; Fang Zhang; Yasuhiro Takeuchi
Safer, silencing-resistant lentiviral vectors: optimization of the ubiquitous chromatin-opening element through elimination of aberrant splicing.
Journal of virology 2012;86(17):9088-95.
2012: Christine Rivat; Giorgia Santilli; H Bobby Gaspar; Adrian J Thrasher
Gene therapy for primary immunodeficiencies.
Human gene therapy 2012;23(7):668-75.
2012: Claudia A Montiel-Equihua; Heba Saadeh; Manfred Schmidt; Simone Scholz; Reiner Schulz; Yasuhiro Takeuchi; Adrian J Thrasher; Lin Zhang; Maria E Alonso-Ferrero; Michael Antoniou; Michael P Blundell; Marlene Carmo; Mary Collins; Lynette Fairbanks; Sean Knight; Aiste Monkeviciute; H Bobby Gaspar
The β-globin locus control region in combination with the EF1α short promoter allows enhanced lentiviral vector-mediated erythroid gene expression with conserved multilineage activity.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(7):1400-9.
2012: Lee Macpherson; James Monypenny; Adrian J Thrasher; Jessica Tomé-García; Michael P Blundell; Giles O Cory; Gareth E Jones; Yolanda Calle
Tyrosine phosphorylation of WASP promotes calpain-mediated podosome disassembly.
Haematologica 2012;97(5):687-91.
2012: Nourredine Himoudi; K Howe; A Michalski; Kathryn L Parsley; N J Sebire; Adrian J Thrasher; R Wallace; A-U Barrie; R Dong; Kimberly C Gilmour; J Anderson
Lack of T-cell responses following autologous tumour lysate pulsed dendritic cell vaccination, in patients with relapsed osteosarcoma.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2012;14(4):271-9.
2012: Claudia A Montiel-Equihua; Adrian J Thrasher; H Bobby Gaspar
Gene therapy for severe combined immunodeficiency due to adenosine deaminase deficiency.
Current gene therapy 2012;12(1):57-65.
2012: Samantha Cooray; Steven J Howe; Adrian J Thrasher
Retrovirus and lentivirus vector design and methods of cell conditioning.
Methods in enzymology 2012;507():29-57.
2012: Wei-Li Di; John I Harper; Fernando Larcher; Ekaterina Semenova; Adrian J Thrasher; Marcela Del Rio; Waseem Qasim
Human involucrin promoter mediates repression-resistant and compartment-specific LEKTI expression.
Human gene therapy 2012;23(1):83-90.
2011: Anne Galy; Adrian J Thrasher
Gene therapy for the Wiskott-Aldrich syndrome.
Current opinion in allergy and clinical immunology 2011;11(6):545-50.
2011: Claire Booth; H Bobby Gaspar; Adrian J Thrasher
Gene therapy for primary immunodeficiency.
Current opinion in pediatrics 2011;23(6):659-66.
2011: Anil Abeyewickreme; Adrian J Thrasher; Christine Kinnon
Bone morphogenetic protein-4 (BMP4) up regulates key haematopoietic genes in differentiating embryonic stem cells treated with BMP4 short hairpin RNA.
British journal of haematology 2011;155(5):638-41.
2011: Annette Deichmann; Cynthia E Dunbar; Alain Fischer; Richard Gabriel; H Bobby Gaspar; Hanno Glimm; Manuel Grez; Salima Hacein-Bey-Abina; Dieter Hoelzer; Steven J Howe; Fulvio Mavilio; Marion G Ott; Anna Paruzynski; Manfred Schmidt; Kerstin Schwarzwaelder; Reinhard Seger; Adrian J Thrasher; Monique M A Verstegen; Christof von Kalle; Ulrich Abel; Alessandro Aiuti; Anne Arens; Cynthia C Bartholomae; Christopher Baum; Martijn Brugman; Barbara Cassani; Claudia Cattoglio; Marina Cavazzana-Calvo; Gerard Wagemaker
Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(11):2031-9.
2011: Sayandip Mukherjee; Adrian J Thrasher
Progress and prospects: advancements in retroviral vector design, generation, and application.
Human gene therapy 2011;22(10):1171-4.
2011: Marshall W Huston; Yuedan Li; Fulvio Mavilio; Ali Nowrouzi; Axel Schambach; Manfred Schmidt; Adrian J Thrasher; Niek P van Til; Monique M A Verstegen; Trudi P Visser; Christof von Kalle; Shazia Arshad; Christopher Baum; Mike P Blundell; Martijn Brugman; Claudia Cattoglio; Fang Zhang; Gerard Wagemaker
Correction of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(10):1867-77.
2011: Ariadna Mendoza-Naranjo; Cristian Pereda; Marcos Ramírez; David Becker; Gerben Bouma; Alexis M Kalergis; Mercedes N López; Adrian J Thrasher; Andrés Tittarelli; Kevin F Webb; Flavio Salazar-Onfray
Functional gap junctions accumulate at the immunological synapse and contribute to T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(6):3121-32.
2011: Gerben Bouma; Siobhan O Burns; Elena de Falco; Ariadna Mendoza-Naranjo; Kathryn L Parsley; Michael P Blundell; Adrian J Thrasher
Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming.
Blood 2011;118(9):2492-501.
2011: Karin Pike-Overzet; M Rodijk; A Schambach; Adrian J Thrasher; J J M van Dongen; F Zhang; M R M Baert; Christopher Baum; R G M Bredius; M Cavazzana-Calvo; G J A Driessen; Salima Hacein-Bey-Abina; Rob Hoeben; C Lagresle-Peyrou; Arjan C Lankester; Yuk Yin Ng; Frank Staal
Correction of murine Rag1 deficiency by self-inactivating lentiviral vector-mediated gene transfer.
Leukemia 2011;25(9):1471-83.
2011: H Bobby Gaspar; Kimberly C Gilmour; Christine Kinnon; Kathryn L Parsley; Theoni Petropolou; Paul Veys; Fang Zhang; Theoni Petropoulou; Stuart Adams; Jinhua Bayford; Emma Bjorkegren; Victoria Bordon; Lucinda Brown; Samantha Cooray; E Graham Davies; Lynette Fairbanks; Adrian J Thrasher
Hematopoietic stem cell gene therapy for adenosine deaminase-deficient severe combined immunodeficiency leads to long-term immunological recovery and metabolic correction.
Science translational medicine 2011;3(97):97ra80.
2011: H Bobby Gaspar; Kimberly C Gilmour; Steven J Howe; Christine Kinnon; Kathryn L Parsley; Stuart Adams; Abdulaziz Al-Ghonaium; Jinhua Bayford; Lucinda Brown; Samantha Cooray; E Graham Davies; Adrian J Thrasher
Long-term persistence of a polyclonal T cell repertoire after gene therapy for X-linked severe combined immunodeficiency.
Science translational medicine 2011;3(97):97ra79.
2011: Joao Metelo; Adrian J Thrasher; Natalie Ward; Siobhan O Burns
Lentivectors are efficient tools to manipulate the dendritic cell cytoskeleton.
Cytoskeleton (Hoboken, N.J.) 2011;68(8):434-45.
2011: Sayandip Mukherjee; Adrian J Thrasher
iPSCs: Unstable origins?
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(7):1188-90.
2011: Chiara Bacchelli; Karen F Buckland; Sylvie Buckridge; Ulrich Salzer; Pascal Schneider; Adrian J Thrasher; H Bobby Gaspar
The C76R transmembrane activator and calcium modulator cyclophilin ligand interactor mutation disrupts antibody production and B-cell homeostasis in heterozygous and homozygous mice.
The Journal of allergy and clinical immunology 2011;127(5):1253-9.e13.
2011: Cynthia C Bartholomae; Anne Arens; Kamaljit S Balaggan; Rafael J Yáñez-Muñoz; Eugenio Montini; Steven J Howe; Anna Paruzynski; Bernhard Korn; Jens Uwe Appelt; Angus Macneil; Daniela Cesana; Ulrich Abel; Hanno Glimm; Luigi Naldini; Robin R Ali; Adrian J Thrasher; Christof von Kalle; Manfred Schmidt
Lentiviral vector integration profiles differ in rodent postmitotic tissues.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(4):703-10.
2011: Wei-Li Di; Fernado Larcher; Ekaterina Semenova; Gill E Talbot; John I Harper; Marcela Del Rio; Adrian J Thrasher; Waseem Qasim
Ex-vivo gene therapy restores LEKTI activity and corrects the architecture of Netherton syndrome-derived skin grafts.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(2):408-16.
2011: James Monypenny; Hsiu-Chuan Chou; Inmaculada Bañón-Rodríguez; Adrian J Thrasher; Inés M Antón; Gareth E Jones; Yolanda Calle
Role of WASP in cell polarity and podosome dynamics of myeloid cells.
European journal of cell biology 2011;90(2-3):198-204.
2011: Natalie J Ward; Suzanne M K Buckley; Simon Waddington; Thierry Vandendriessche; Marinee K L Chuah; Amit C Nathwani; Jenny McIntosh; Edward G D Tuddenham; Christine Kinnon; Adrian J Thrasher; John H McVey
Codon optimization of human factor VIII cDNAs leads to high-level expression.
Blood 2011;117(3):798-807.
2011: Sayandip Mukherjee; Giorgia Santilli; Michael P Blundell; Susana Navarro; Juan A. Bueren; Adrian J Thrasher
Generation of functional neutrophils from a mouse model of X-linked chronic granulomatous disorder using induced pluripotent stem cells.
PloS one 2011;6(3):e17565.
2011: Manuel Grez; Janine Reichenbach; Joachim Schwäble; Reinhard Seger; Mary C Dinauer; Adrian J Thrasher
Gene therapy of chronic granulomatous disease: the engraftment dilemma.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(1):28-35.
2011: Giorgia Santilli; Elena Almarza; Christian Brendel; Uimook Choi; Chiara Beilin; Michael P Blundell; Sneha Haria; Kathryn L Parsley; Christine Kinnon; Harry L Malech; Juan A. Bueren; Manuel Grez; Adrian J Thrasher
Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(1):122-32.
2010: Nicole Kane; Ali Nowrouzi; Sayandip Mukherjee; Michael P Blundell; Jenny A Greig; Wai Kwong Lee; Miles D Houslay; Graeme Milligan; joanne mountford; Christof von Kalle; Manfred Schmidt; Adrian J Thrasher; Andrew H Baker
Lentivirus-mediated reprogramming of somatic cells in the absence of transgenic transcription factors.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(12):2139-45.
2010: Gerben Bouma; Phil J Ancliff; Adrian J Thrasher; Siobhan O Burns
Recent advances in the understanding of genetic defects of neutrophil number and function.
British journal of haematology 2010;151(4):312-26.
2010: Fang Zhang; Amy R Frost; Mike P Blundell; Olivia Bales; Michael N Antoniou; Adrian J Thrasher
A ubiquitous chromatin opening element (UCOE) confers resistance to DNA methylation-mediated silencing of lentiviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(9):1640-9.
2010: Waseem Qasim; Conrad A Vink; Adrian J Thrasher
Hybrid lentiviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(7):1263-7.
2010: E Graham Davies; Adrian J Thrasher
Update on the hyper immunoglobulin M syndromes.
British journal of haematology 2010;149(2):167-80.
2010: Stefan Stein; Marion G Ott; Stephan Schultze-Strasser; Anna Jauch; Barbara Burwinkel; Andrea Kinner; Manfred Schmidt; Alwin Krämer; Joachim Schwäble; Hanno Glimm; Ulrike Koehl; Carolin Preiss; Claudia Ball; Hans Martin; Gudrun Göhring; Kerstin Schwarzwaelder; Wolf-Karsten Hofmann; Kadin Karakaya; Sandrine Tchatchou; Rongxi Yang; Petra Reinecke; Klaus Kühlcke; Brigitte Schlegelberger; Adrian J Thrasher; Dieter Hoelzer; Reinhard Seger; Christof von Kalle; Manuel Grez
Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease.
Nature medicine 2010;16(2):198-204.
2010: Anastasios Georgiadis; Marion Tschernutter; J W B Bainbridge; Kamaljit S Balaggan; Freya Mowat; Emma L West; Peter M G Munro; Adrian J Thrasher; Karl Matter; Maria S Balda; Robin R Ali
The tight junction associated signalling proteins ZO-1 and ZONAB regulate retinal pigment epithelium homeostasis in mice.
PloS one 2010;5(12):e15730.
2010: Michael P Blundell; Austen Worth; Gerben Bouma; Adrian J Thrasher
The Wiskott-Aldrich syndrome: The actin cytoskeleton and immune cell function.
Disease markers 2010;29(3-4):157-75.
2009: Yin Wu; Wutian Wu; Wai Man Wong; Eliot Ward; Adrian J Thrasher; David Goldblatt; Mohamed Osman; Paul Digard; David H Canaday; Kenth Gustafsson
Human gamma delta T cells: a lymphoid lineage cell capable of professional phagocytosis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(9):5622-9.
2009: Waseem Qasim; H Bobby Gaspar; Adrian J Thrasher
Progress and prospects: gene therapy for inherited immunodeficiencies.
Gene therapy 2009;16(11):1285-91.
2009: Ute Modlich; Susana Navarro; Daniela Zychlinski; Tobias Maetzig; Sabine Knoess; Martijn Brugman; Axel Schambach; Sabine Charrier; Anne Galy; Adrian J Thrasher; Juan Bueren; Christopher Baum
Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(11):1919-28.
2009: Gerben Bouma; Rainer Doffinger; Smita Y Patel; Emma Peskett; Joanna C Sinclair; Gabriela Barcenas-Morales; Lourdes Cerron-Gutierrez; Dinakantha S Kumararatne; E Graham Davies; Adrian J Thrasher; Siobhan O Burns
Impaired neutrophil migration and phagocytosis in IRAK-4 deficiency.
British journal of haematology 2009;147(1):153-6.
2009: Michael P Blundell; Gerben Bouma; Joao Metelo; Austen Worth; Yolanda Calle; Lucy A Cowell; Lisa S Westerberg; Dale A Moulding; Samuel Mirando; Christine Kinnon; Giles O Cory; Gareth E Jones; Scott B Snapper; Siobhan O Burns; Adrian J Thrasher
Phosphorylation of WASp is a key regulator of activity and stability in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(37):15738-43.
2009: Conrad A Vink; H Bobby Gaspar; richard gabriel; Manfred Schmidt; R Scott McIvor; Adrian J Thrasher; Waseem Qasim
Sleeping beauty transposition from nonintegrating lentivirus.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(7):1197-204.
2009: Linda Scobie; Ralph D Hector; Louise Grant; Margaret Bell; Anne A Nielsen; Sharon Meikle; Adrian Philbey; Adrain Philbey; Adrian J Thrasher; Adrain J Thrasher; Ewan R Cameron; Karen Blyth; James C Neil
A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of gammaC gene oncogenicity.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(6):1031-8.
2009: A A Rahim; A M S Wong; Steven J Howe; S M K Buckley; A D Acosta-Saltos; K E Elston; N J Ward; Nicola Philpott; J D Cooper; Patrick N Anderson; Simon Waddington; Adrian J Thrasher; G Raivich
Efficient gene delivery to the adult and fetal CNS using pseudotyped non-integrating lentiviral vectors.
Gene therapy 2009;16(4):509-20.
2009: Adrian J Thrasher
New insights into the biology of Wiskott-Aldrich syndrome (WAS).
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2009;():132-8.
2009: Gerben Bouma; Siobhan O Burns; Adrian J Thrasher
Wiskott-Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activation.
Immunobiology 2009;214(9-10):778-90.
2009: Bibiana Moreno-Carranza; M Gentsch; Stefan Stein; A Schambach; G Santilli; E Rudolf; M F Ryser; S Haria; Adrian J Thrasher; C Baum; S Brenner; Manuel Grez
Transgene optimization significantly improves SIN vector titers, gp91phox expression and reconstitution of superoxide production in X-CGD cells.
Gene therapy 2009;16(1):111-8.
2008: Nourredine Himoudi; Stephen Nabarro; Jo Buddle; Ayad Eddaoudi; Adrian J Thrasher; John Anderson
Bone marrow-derived IFN-producing killer dendritic cells account for the tumoricidal activity of unpulsed dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):6654-63.
2008: Suzanne Buckley; Steven J Howe; Ahad A Rahim; Hildegard Buning; Jenny McIntosh; Suet-Ping Wong; Andrew H Baker; Amit Nathwani; Adrian J Thrasher; Charles Coutelle; Tristan R McKay; Simon Waddington
Luciferin detection after intranasal vector delivery is improved by intranasal rather than intraperitoneal luciferin administration.
Human gene therapy 2008;19(10):1050-6.
2008: Yolanda Calle; Inés M Antón; Adrian J Thrasher; Gareth E Jones
WASP and WIP regulate podosomes in migrating leukocytes.
Journal of microscopy 2008;231(3):494-505.
2008: Steven J Howe; Marc R Mansour; Kerstin Schwarzwaelder; Cynthia Bartholomae; Michael Hubank; Helena Kempski; Martijn Brugman; Karin Pike-Overzet; Stephen J Chatters; Dick de Ridder; Kimberly C Gilmour; Stuart Adams; Susannah I Thornhill; Kathryn L Parsley; Frank Staal; Rosemary E Gale; David C Linch; Jinhua Bayford; Lucie Brown; Michelle Quaye; Christine Kinnon; Philip Ancliff; David K Webb; Manfred Schmidt; Christof von Kalle; H Bobby Gaspar; Adrian J Thrasher
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients.
The Journal of clinical investigation 2008;118(9):3143-50.
2008: Suzanne Buckley; S J Howe; V Sheard; N J Ward; Charles Coutelle; Adrian J Thrasher; Simon Waddington; T R McKay
Lentiviral transduction of the murine lung provides efficient pseudotype and developmental stage-dependent cell-specific transgene expression.
Gene therapy 2008;15(16):1167-75.
2008: J W B Bainbridge; Alexander J Smith; Susie S Barker; Scott Robbie; Robert Henderson; Kamaljit Balaggan; Ananth Viswanathan; Graham Holder; Andrew Stockman; Nick Tyler; Simon Petersen-Jones; Shomi S Bhattacharya; Adrian J Thrasher; Frederick W Fitzke; Barrie J Carter; Gary Rubin; Anthony T Moore; Robin R Ali
Effect of gene therapy on visual function in Leber's congenital amaurosis.
The New England journal of medicine 2008;358(21):2231-9.
2008: Adrian J Thrasher
Gene therapy for primary immunodeficiencies.
Immunology and allergy clinics of North America 2008;28(2):457-71, xi.
2008: Michael P Blundell; Gerben Bouma; Yolanda Calle; Gareth E Jones; Christine Kinnon; Adrian J Thrasher
Improvement of migratory defects in a murine model of Wiskott-Aldrich syndrome gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(5):836-44.
2008: Susannah I Thornhill; Axel Schambach; Steven J Howe; Meera Ulaganathan; Elke Grassman; David Williams; Bernhard Schiedlmeier; Neil J Sebire; H Bobby Gaspar; Christine Kinnon; Christopher Baum; Adrian J Thrasher
Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodeficiency.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(3):590-8.
2007: K L Laurie; Michael P Blundell; H E Baxendale; Steven J Howe; Joanna Sinclair; Waseem Qasim; U Brunsberg; Adrian J Thrasher; R Holmdahl; Kenth Gustafsson
Cell-specific and efficient expression in mouse and human B cells by a novel hybrid immunoglobulin promoter in a lentiviral vector.
Gene therapy 2007;14(23):1623-31.
2007: Waseem Qasim; H Bobby Gaspar; Adrian J Thrasher
Update on clinical gene therapy in childhood.
Archives of disease in childhood 2007;92(11):1028-31.
2007: Luis Apolonia; Simon Waddington; Carolina Fernandes; Natalie J Ward; Gerben Bouma; Michael P Blundell; Adrian J Thrasher; Mary K Collins; Nicola Philpott
Stable gene transfer to muscle using non-integrating lentiviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(11):1947-54.
2007: Caroline J Marshall; Joanna C Sinclair; Adrian J Thrasher; Christine Kinnon
Bone morphogenetic protein 4 modulates c-Kit expression and differentiation potential in murine embryonic aorta-gonad-mesonephros haematopoiesis in vitro.
British journal of haematology 2007;139(2):321-30.
2007: Claudia Cattoglio; Giulia Facchini; Daniela Sartori; Antonella Antonelli; Annarita Miccio; Barbara Cassani; Manfred Schmidt; Christof von Kalle; Steven J Howe; Adrian J Thrasher; Alessandro Aiuti; Giuliana Ferrari; Alessandra Recchia; Fulvio Mavilio
Hot spots of retroviral integration in human CD34+ hematopoietic cells.
Blood 2007;110(6):1770-8.
2007: Dale A Moulding; Michael P Blundell; David G Spiller; Michael R H White; Giles O Cory; Yolanda Calle; Helena Kempski; Joanna Sinclair; Phil J Ancliff; Christine Kinnon; Gareth E Jones; Adrian J Thrasher
Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia.
The Journal of experimental medicine 2007;204(9):2213-24.
2007: Chiara Bacchelli; Sylvie Buckridge; Adrian J Thrasher; H Bobby Gaspar
Translational mini-review series on immunodeficiency: molecular defects in common variable immunodeficiency.
Clinical and experimental immunology 2007;149(3):401-9.
2007: Fang Zhang; Susannah I Thornhill; Steven J Howe; Meera Ulaganathan; Axel Schambach; Joanna Sinclair; Christine Kinnon; H Bobby Gaspar; Michael Antoniou; Adrian J Thrasher
Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells.
Blood 2007;110(5):1448-57.
2007: Nourredine Himoudi; Steven Nabarro; Mengyong Yan; Kimberly C Gilmour; Adrian J Thrasher; John Anderson
Development of anti-PAX3 immune responses; a target for cancer immunotherapy.
Cancer immunology, immunotherapy : CII 2007;56(9):1381-95.
2007: Kerstin Schwarzwaelder; Steven J Howe; Manfred Schmidt; Martijn Brugman; Annette Deichmann; Hanno Glimm; Sonja Schmidt; Claudia Prinz; Manuela Wissler; Douglas J S King; Fang Zhang; Kathryn L Parsley; Kimberly C Gilmour; Joanna Sinclair; Jinhua Bayford; Rachel Peraj; Karin Pike-Overzet; Frank Staal; Dick de Ridder; Christine Kinnon; Ulrich Abel; Gerard Wagemaker; H Bobby Gaspar; Adrian J Thrasher; Christof von Kalle
Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo.
The Journal of clinical investigation 2007;117(8):2241-9.
2007: Susie E Barker; S M Grosse; Elena K Siapati; A Kritz; Christine Kinnon; Adrian J Thrasher; Stephen Hart
Immunotherapy for neuroblastoma using syngeneic fibroblasts transfected with IL-2 and IL-12.
British journal of cancer 2007;97(2):210-7.
2007: J J Kim; Adrian J Thrasher; AM Jones; E Graham Davies; Catherine M Cale
Rituximab for the treatment of autoimmune cytopenias in children with immune deficiency.
British journal of haematology 2007;138(1):94-6.
2007: Ulrich Salzer; Jennifer Birmelin; Chiara Bacchelli; Torsten Witte; Ulrike Buchegger-Podbielski; Sylvie Buckridge; Rita Rzepka; H Bobby Gaspar; Adrian J Thrasher; Reinhold E Schmidt; Inga Melchers; Bodo Grimbacher
Sequence analysis of TNFRSF13b, encoding TACI, in patients with systemic lupus erythematosus.
Journal of clinical immunology 2007;27(4):372-7.
2007: Nicola Philpott; Adrian J Thrasher
Use of nonintegrating lentiviral vectors for gene therapy.
Human gene therapy 2007;18(6):483-9.
2007: Elena K Siapati; Brian W Bigger; Karl Kashofer; Michael Themis; Adrian J Thrasher; Dominique Bonnet
Murine leukemia following irradiation conditioning for transplantation of lentivirally-modified hematopoietic stem cells.
European journal of haematology 2007;78(4):303-13.
2007: Karin Pike-Overzet; Dick de Ridder; Floor Weerkamp; Miranda Baert; M M A Verstegen; Martijn Brugman; Steven J Howe; Marcel J T Reinders; Adrian J Thrasher; Gerard Wagemaker; Jacques J M van Dongen; Frank Staal
Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy.
Leukemia 2007;21(4):754-63.
2007: Waseem Qasim; Taylor Mackey; Joanna Sinclair; Ilenia Chatziandreou; Christine Kinnon; Adrian J Thrasher; H Bobby Gaspar
Lentiviral vectors for T-cell suicide gene therapy: preservation of T-cell effector function after cytokine-mediated transduction.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(2):355-60.
2007: Ulrich Abel; Annette Deichmann; Cynthia Bartholomae; Kerstin Schwarzwaelder; Hanno Glimm; Steven J Howe; Adrian J Thrasher; Alexandrine Garrigue; Salima Hacein-Bey-Abina; Marina Cavazzana-Calvo; Alain Fischer; Dirk Jaeger; Christof von Kalle; Manfred Schmidt
Real-time definition of non-randomness in the distribution of genomic events.
PloS one 2007;2(6):e570.
2006: Hsiu-Chuan Chou; Inés M Antón; Mark Holt; Claudia Curcio; Stefania Lanzardo; Austen Worth; Siobhan Burns; Adrian J Thrasher; Gareth E Jones; Yolanda Calle
WIP regulates the stability and localization of WASP to podosomes in migrating dendritic cells.
Current biology : CB 2006;16(23):2337-44.
2006: Claire Booth; Jean-Antoine Ribeil; Françoise Audat; Liliane Dal Cortivo; Paul Veys; Adrian J Thrasher; E Graham Davies; François Lefrère; Alain Fischer; Marina Cavazzana-Calvo; H Bobby Gaspar
CD34 stem cell top-ups without conditioning after initial haematopoietic stem cell transplantation for correction of incomplete haematopoietic and immunological recovery in severe congenital immunodeficiencies.
British journal of haematology 2006;135(4):533-7.
2006: H Bobby Gaspar; Emma Bjorkegren; Kathryn L Parsley; Kimberly C Gilmour; Doug King; Joanna Sinclair; Fang Zhang; Aris Giannakopoulos; Stuart Adams; Lynette D Fairbanks; Jane Gaspar; Lesley Henderson; Jin Hua Xu-Bayford; E Graham Davies; Paul Veys; Christine Kinnon; Adrian J Thrasher
Successful reconstitution of immunity in ADA-SCID by stem cell gene therapy following cessation of PEG-ADA and use of mild preconditioning.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(4):505-13.
2006: Phil J Ancliff; Michael P Blundell; Giles O Cory; Yolanda Calle; Austen Worth; Helena Kempski; Siobhan Burns; Gareth E Jones; Joanna Sinclair; Christine Kinnon; Ian Hann; Rosemary E Gale; David C Linch; Adrian J Thrasher
Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia.
Blood 2006;108(7):2182-9.
2006: Karin Pike-Overzet; Dick de Ridder; Floor Weerkamp; Miranda Baert; Monique M Verstegen; Martijn Brugman; Steven J Howe; Marcel J T Reinders; Adrian J Thrasher; Gerard Wagemaker; Jacques J M van Dongen; Frank Staal
Gene therapy: is IL2RG oncogenic in T-cell development?
Nature 2006;443(7109):E5; discussion E6-7.
2006: Adrian J Thrasher; H Bobby Gaspar; Christopher Baum; Ute Modlich; Axel Schambach; Fabio Candotti; Makoto Otsu; Brian P Sorrentino; Linda Scobie; Ewan Cameron; Karen Blyth; Jim Neil; Salima Hacein-Bey Abina; Marina Cavazzana-Calvo; Alain Fischer
Gene therapy: X-SCID transgene leukaemogenicity.
Nature 2006;443(7109):E5-6; discussion E6-7.
2006: Yolanda Calle; Neil O Carragher; Adrian J Thrasher; Gareth E Jones
Inhibition of calpain stabilises podosomes and impairs dendritic cell motility.
Journal of cell science 2006;119(Pt 11):2375-85.
2006: Jez Fabes; Patrick Anderson; Rafael J Yáñez-Muñoz; Adrian J Thrasher; Caroline Brennan; Stephen Bolsover
Accumulation of the inhibitory receptor EphA4 may prevent regeneration of corticospinal tract axons following lesion.
The European journal of neuroscience 2006;23(7):1721-30.
2006: Austen Worth; Adrian J Thrasher; H Bobby Gaspar
Autoimmune lymphoproliferative syndrome: molecular basis of disease and clinical phenotype.
British journal of haematology 2006;133(2):124-40.
2006: Marion G Ott; Manfred Schmidt; Kerstin Schwarzwaelder; Stefan Stein; Ulrich Siler; Ulrike Koehl; Hanno Glimm; Klaus Kühlcke; Andrea Schilz; Hana Kunkel; Sonja Naundorf; Andrea Brinkmann; Annette Deichmann; Marlene Fischer; Claudia Ball; Ingo Pilz; Cynthia Dunbar; Yang Du; Nancy A Jenkins; Neal G Copeland; Ursula Lüthi; Moustapha Hassan; Adrian J Thrasher; Dieter Hoelzer; Christof von Kalle; Reinhard Seger; Manuel Grez
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.
Nature medicine 2006;12(4):401-9.
2006: Yolanda Calle; Siobhan Burns; Adrian J Thrasher; Gareth E Jones
The leukocyte podosome.
European journal of cell biology 2006;85(3-4):151-7.
2006: Rafael J Yáñez-Muñoz; Kamaljit S Balaggan; Angus MacNeil; Steven J Howe; Manfred Schmidt; Alexander J Smith; Prateek Buch; Robert MacLaren; Patrick N Anderson; Susie E Barker; Yanai Duran; Cynthia Bartholomae; Christof von Kalle; John R Heckenlively; Christine Kinnon; Robin R Ali; Adrian J Thrasher
Effective gene therapy with nonintegrating lentiviral vectors.
Nature medicine 2006;12(3):348-53.
2006: Brian W Bigger; Elena K Siapati; Ajay R Mistry; Simon Waddington; Megha Nivsarkar; L Jacobs; R Perrett; Maxine V Holder; C Ridler; Geoffrey Kemball-Cook; Robin R Ali; Stuart J Forbes; Charles Coutelle; N Wright; Stuart McDonald; Adrian J Thrasher; Dominique Bonnet; Michael Themis
Permanent partial phenotypic correction and tolerance in a mouse model of hemophilia B by stem cell gene delivery of human factor IX.
Gene therapy 2006;13(2):117-26.
2005: Steven Nabarro; Nourredine Himoudi; Antigoni Papanastasiou; Kimberly C Gilmour; Sian Gibson; Neil J Sebire; Adrian J Thrasher; Michael P Blundell; Mike Hubank; Glenda Canderan; John Anderson
Coordinated oncogenic transformation and inhibition of host immune responses by the PAX3-FKHR fusion oncoprotein.
The Journal of experimental medicine 2005;202(10):1399-410.
2005: Shao-An Xue; Liquan Gao; Daniel Hart; Roopinder Gillmore; Waseem Qasim; Adrian J Thrasher; Jane Apperley; Boris Engels; Wolfgang Uckert; Emma Morris; Hans J Stauss
Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene-transduced human T cells.
Blood 2005;106(9):3062-7.
2005: Michael Themis; Simon Waddington; Manfred Schmidt; Christof von Kalle; Yoahe Wang; Faisal Al-Allaf; Lisa G Gregory; Megha Nivsarkar; Matthew Themis; Maxine V Holder; Suzanne Buckley; Niraja Dighe; Ali Ruthe; Ajay R Mistry; Brian W Bigger; Ahad Rahim; Tuan H Nguyen; Didier Trono; Adrian J Thrasher; Charles Coutelle
Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(4):763-71.
2005: H Bobby Gaspar; Adrian J Thrasher
Gene therapy for severe combined immunodeficiencies.
Expert opinion on biological therapy 2005;5(9):1175-82.
2005: Elena K Siapati; Brian W Bigger; James Miskin; Daniel Chipchase; Kathryn L Parsley; Kyriacos A Mitrophanous; Michael Themis; Adrian J Thrasher; Dominique Bonnet
Comparison of HIV- and EIAV-based vectors on their efficiency in transducing murine and human hematopoietic repopulating cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(3):537-46.
2005: Cathryn Broderick; Alexander J Smith; Kamaljit S Balaggan; Anastasios Georgiadis; Anastasios Georgarias; Prateek K Buch; Peter Trittibach; Susie E Barker; Gian-Marco Sarra; Adrian J Thrasher; Andrew D Dick; Robin R Ali
Local administration of an adeno-associated viral vector expressing IL-10 reduces monocyte infiltration and subsequent photoreceptor damage during experimental autoimmune uveitis.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(2):369-73.
2005: Adrian J Thrasher; H Bobby Gaspar
Gene therapy in primary immunodeficiencies.
Expert review of clinical immunology 2005;1(2):239-45.
2005: Adrian J Thrasher; H Bobby Gaspar
Gene therapy for lympho-hematopoietic disorders.
Current hematology reports 2005;4(4):305-9.
2005: Adrian J Thrasher; Salima Hacein-Bey-Abina; H Bobby Gaspar; Stéphane Blanche; E Graham Davies; Kathryn L Parsley; Kimberly C Gilmour; Douglas King; Steven J Howe; Joanna Sinclair; Christophe Hue; Frédérique Carlier; Christof von Kalle; Geneviève de Saint Basile; Françoise Le Deist; Alain Fischer; Marina Cavazzana-Calvo
Failure of SCID-X1 gene therapy in older patients.
Blood 2005;105(11):4255-7.
2005: Marion Tschernutter; Frank C Schlichtenbrede; Steven J Howe; Kamaljit S Balaggan; Peter M G Munro; J W B Bainbridge; Adrian J Thrasher; Alexander J Smith; Robin R Ali
Long-term preservation of retinal function in the RCS rat model of retinitis pigmentosa following lentivirus-mediated gene therapy.
Gene therapy 2005;12(8):694-701.
2005: Sofia de Noronha; Samantha Hardy; Joanna Sinclair; Michael P Blundell; Jessica Strid; Oliver Schulz; Jörg Zwirner; Gareth E Jones; David R Katz; Christine Kinnon; Adrian J Thrasher
Impaired dendritic-cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein.
Blood 2005;105(4):1590-7.
2005: Waseem Qasim; H Bobby Gaspar; Adrian J Thrasher
T cell suicide gene therapy to aid haematopoietic stem cell transplantation.
Current gene therapy 2005;5(1):121-32.
2004: H Bobby Gaspar; Kathryn L Parsley; Steven J Howe; Doug King; Kimberly C Gilmour; Joanna Sinclair; Gaby Brouns; Manfred Schmidt; Christof von Kalle; Torben Barington; Marianne A Jakobsen; Hans O Christensen; Abdulaziz Al-Ghonaium; Harry N White; John L Smith; Roland J Levinsky; Robin R Ali; Christine Kinnon; Adrian J Thrasher
Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector.
Lancet 2004;364(9452):2181-7.
2004: Siobhan Burns; Giles O Cory; William Vainchenker; Adrian J Thrasher
Mechanisms of WASp-mediated hematologic and immunologic disease.
Blood 2004;104(12):3454-62.
2004: Siobhan Burns; Adrian J Thrasher
Dendritic cells: the bare bones of immunity.
Current biology : CB 2004;14(22):R965-7.
2004: Yolanda Calle; Hsiu-Chuan Chou; Adrian J Thrasher; Gareth E Jones
Wiskott-Aldrich syndrome protein and the cytoskeletal dynamics of dendritic cells.
The Journal of pathology 2004;204(4):460-9.
2004: Simon Waddington; Megha Nivsarkar; Ajay R Mistry; Suzanne Buckley; Geoffrey Kemball-Cook; Karen L Mosley; Kyriacos A Mitrophanous; Pippa Radcliffe; Maxine V Holder; Mairi Brittan; Anastasios Georgiadis; Faisal Al-Allaf; Brian W Bigger; Lisa G Gregory; H Terence Cook; Robin R Ali; Adrian J Thrasher; Edward G D Tuddenham; Michael Themis; Charles Coutelle
Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy.
Blood 2004;104(9):2714-21.
2004: Waseem Qasim; H Bobby Gaspar; Adrian J Thrasher
Gene therapy for severe combined immune deficiency.
Expert reviews in molecular medicine 2004;6(13):1-15.
2004: Oliver Schwickerath; Gaby Brouns; Adrian J Thrasher; Christine Kinnon; Jürgen Roes; Colin Casimir
Enhancer-deleted retroviral vectors restore high levels of superoxide generation in a mouse model of CGD.
The journal of gene medicine 2004;6(6):603-15.
2004: Reza Sharifi; Joanna C Sinclair; Kimberly C Gilmour; Peter Arkwright; Christine Kinnon; Adrian J Thrasher; H Bobby Gaspar
SAP mediates specific cytotoxic T-cell functions in X-linked lymphoproliferative disease.
Blood 2004;103(10):3821-7.
2004: M J Booth; Ajay R Mistry; X Li; Adrian J Thrasher; Robert S Coffin
Transfection-free and scalable recombinant AAV vector production using HSV/AAV hybrids.
Gene therapy 2004;11(10):829-37.
2004: Yolanda Calle; Gareth E Jones; Christopher J Jagger; Karen Fuller; Michael P Blundell; Jade Chow; Timothy Chambers; Adrian J Thrasher
WASp deficiency in mice results in failure to form osteoclast sealing zones and defects in bone resorption.
Blood 2004;103(9):3552-61.
2004: Forhad Ahmed; Stuart J Ings; Arnold Pizzey; Michael P Blundell; Adrian J Thrasher; Hong T Ye; Anne Fahey; David C Linch; Kwee Yong
Impaired bone marrow homing of cytokine-activated CD34+ cells in the NOD/SCID model.
Blood 2004;103(6):2079-87.
2004: Siobhan Burns; Samantha J Hardy; Joanna Buddle; Kwee Yong; Gareth E Jones; Adrian J Thrasher
Maturation of DC is associated with changes in motile characteristics and adherence.
Cell motility and the cytoskeleton 2004;57(2):118-32.
2004: Frank C Schlichtenbrede; Alexander J Smith; J W B Bainbridge; Adrian J Thrasher; Thomas E Salt; Robin R Ali
Improvement of neuronal visual responses in the superior colliculus in Prph2(Rd2/Rd2) mice following gene therapy.
Molecular and cellular neurosciences 2004;25(1):103-10.
2004: Adrian J Thrasher; Robert G Edwards
Averting abnormal inheritance: potential of gene therapy and preimplantation diagnosis.
Reproductive biomedicine online 2004;8(1):99-106.
2003: Aima Uduehi; Carolina Mailhos; Hazel Truman; Adrian J Thrasher; Christine Kinnon; Stephen Hart
Enhancement of integrin-mediated transfection of haematopoietic cells with a synthetic vector system.
Biotechnology and applied biochemistry 2003;38(Pt 3):201-9.
2003: Chloe M Marden; Deborah S Cunninghame-Graham; Adrian J Thrasher; Colin Casimir
A functional ISRE is required for myeloid transcription of the p47(phox) gene.
Biochimica et biophysica acta 2003;1630(2-3):117-22.
2003: Waseem Qasim; Douglas King; Jo Buddle; Stephanie Verfuerth; Christine Kinnon; Adrian J Thrasher; H Bobby Gaspar
The impact of retroviral suicide gene transduction procedures on T cells.
British journal of haematology 2003;123(4):712-9.
2003: H Bobby Gaspar; Steven J Howe; Adrian J Thrasher
Gene therapy progress and prospects: gene therapy for severe combined immunodeficiency.
Gene therapy 2003;10(24):1999-2004.
2003: Frank C Schlichtenbrede; Lyndon da Cruz; Clare Stephens; Alexander J Smith; Anastasios Georgiadis; Adrian J Thrasher; J W B Bainbridge; Mathias W Seeliger; Robin R Ali
Long-term evaluation of retinal function in Prph2Rd2/Rd2 mice following AAV-mediated gene replacement therapy.
The journal of gene medicine 2003;5(9):757-64.
2003: Alexander J Smith; Frank C Schlichtenbrede; Marion Tschernutter; J W B Bainbridge; Adrian J Thrasher; Robin R Ali
AAV-Mediated gene transfer slows photoreceptor loss in the RCS rat model of retinitis pigmentosa.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(2):188-95.
2003: J W B Bainbridge; Ajay R Mistry; Frank C Schlichtenbrede; A Smith; Cathryn Broderick; Mahesh De Alwis; Anastasios Georgiadis; Paul M Taylor; M Squires; Charanjit S Sethi; David G Charteris; Adrian J Thrasher; D Sargan; Robin R Ali
Stable rAAV-mediated transduction of rod and cone photoreceptors in the canine retina.
Gene therapy 2003;10(16):1336-44.
2003: Steven J Howe; Adrian J Thrasher
Gene therapy for inherited immunodeficiencies.
Current hematology reports 2003;2(4):328-34.
2003: J W B Bainbridge; Ajay R Mistry; Katie Binley; Mahesh De Alwis; Adrian J Thrasher; Stuart Naylor; Robin R Ali
Hypoxia-regulated transgene expression in experimental retinal and choroidal neovascularization.
Gene therapy 2003;10(12):1049-54.
2003: J W B Bainbridge; Ajay R Mistry; Adrian J Thrasher; Robin R Ali
Gene therapy for ocular angiogenesis.
Clinical science (London, England : 1979) 2003;104(6):561-75.
2003: K E Siapati; S Barker; Christine Kinnon; Antony Michalski; R Anderson; PM Brickell; Adrian J Thrasher; Stephen Hart
Improved antitumour immunity in murine neuroblastoma using a combination of IL-2 and IL-12.
British journal of cancer 2003;88(10):1641-8.
2003: Frank C Schlichtenbrede; Angus MacNeil; J W B Bainbridge; Marion Tschernutter; Adrian J Thrasher; Alexander J Smith; Robin R Ali
Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degeneration.
Gene therapy 2003;10(6):523-7.
2002: H Bobby Gaspar; Reza Sharifi; Kimberly C Gilmour; Adrian J Thrasher
X-linked lymphoproliferative disease: clinical, diagnostic and molecular perspective.
British journal of haematology 2002;119(3):585-95.
2002: Katie Binley; Zoe Askham; Sharifah Iqball; Hayley Spearman; Leigh Martin; Mahesh De Alwis; Adrian J Thrasher; Robin R Ali; Patrick H Maxwell; Susan M Kingsman; Stuart Naylor
Long-term reversal of chronic anemia using a hypoxia-regulated erythropoietin gene therapy.
Blood 2002;100(7):2406-13.
2002: Adrian J Thrasher
WASp in immune-system organization and function.
Nature reviews. Immunology 2002;2(9):635-46.
2002: Gareth E Jones; Daniel Zicha; Graham A Dunn; Michael P Blundell; Adrian J Thrasher
Restoration of podosomes and chemotaxis in Wiskott-Aldrich syndrome macrophages following induced expression of WASp.
The international journal of biochemistry & cell biology 2002;34(7):806-15.
2002: Waseem Qasim; Adrian J Thrasher; J Buddle; Christine Kinnon; M E Black; H Bobby Gaspar
T cell transduction and suicide with an enhanced mutant thymidine kinase.
Gene therapy 2002;9(12):824-7.
2002: Jennifer E Morgan; Jacqueline G Gross; Charles N Pagel; Jonathan R Beauchamp; Ariberto Fassati; Adrian J Thrasher; James P Di Santo; Ivan B Fisher; Xu Shiwen; David J Abraham; Terence A Partridge
Myogenic cell proliferation and generation of a reversible tumorigenic phenotype are triggered by preirradiation of the recipient site.
The Journal of cell biology 2002;157(4):693-702.
2002: Christophe Demaison; Kathryn L Parsley; Gaby Brouns; Michaela Scherr; Karin Battmer; Christine Kinnon; Manuel Grez; Adrian J Thrasher
High-level transduction and gene expression in hematopoietic repopulating cells using a human immunodeficiency [correction of imunodeficiency] virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter.
Human gene therapy 2002;13(7):803-13.
2002: Salima Hacein-Bey-Abina; Françoise Le Deist; Frédérique Carlier; Cécile Bouneaud; Christophe Hue; Jean-Pierre De Villartay; Adrian J Thrasher; Nico M Wulffraat; Ricardo U Sorensen; Sophie Dupuis-Girod; Alain Fischer; E Graham Davies; Wietse Kuis; Lilly Leiva; Marina Cavazzana-Calvo
Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy.
The New England journal of medicine 2002;346(16):1185-93.
2002: C L Langrish; Joanna C Buddle; Adrian J Thrasher; D Goldblatt
Neonatal dendritic cells are intrinsically biased against Th-1 immune responses.
Clinical and experimental immunology 2002;128(1):118-23.
2002: J W B Bainbridge; Ajay R Mistry; Mahesh De Alwis; Ewa Paleolog; A Baker; Adrian J Thrasher; Robin R Ali
Inhibition of retinal neovascularisation by gene transfer of soluble VEGF receptor sFlt-1.
Gene therapy 2002;9(5):320-6.
2002: Jian-Mei Li; Adrian M Mullen; Sheng Yun; Frans Wientjes; Gabi Y Brouns; Adrian J Thrasher; Ajay M Shah
Essential role of the NADPH oxidase subunit p47(phox) in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-alpha.
Circulation research 2002;90(2):143-50.
2002: Gian-Marco Sarra; Clare Stephens; Frank C Schlichtenbrede; J W B Bainbridge; Adrian J Thrasher; Philip J Luthert; Robin R Ali
Kinetics of transgene expression in mouse retina following sub-retinal injection of recombinant adeno-associated virus.
Vision research 2002;42(4):541-9.
2002: Kwee Yong; Anne Fahey; Gurmit Pahal; David C Linch; Arnold Pizzey; N Shaun B Thomas; Eric Jauniaux; Christine Kinnon; Adrian J Thrasher
Fetal haemopoietic cells display enhanced migration across endothelium.
British journal of haematology 2002;116(2):392-400.
2002: Ajay R Mistry; Mahesh De Alwis; Elisabeth Feudner; Robin R Ali; Adrian J Thrasher
High-titer stocks of adeno-associated virus from replicating amplicons and herpes vectors.
Methods in molecular medicine 2002;69():445-60.
2001: J W B Bainbridge; Clare Stephens; Kathryn L Parsley; Christophe Demaison; Anthony S Halfyard; Adrian J Thrasher; Robin R Ali
In vivo gene transfer to the mouse eye using an HIV-based lentiviral vector; efficient long-term transduction of corneal endothelium and retinal pigment epithelium.
Gene therapy 2001;8(21):1665-8.
2001: Gian-Marco Sarra; Clare Stephens; Mahesh De Alwis; J W B Bainbridge; Alexander J Smith; Adrian J Thrasher; Robin R Ali
Gene replacement therapy in the retinal degeneration slow (rds) mouse: the effect on retinal degeneration following partial transduction of the retina.
Human molecular genetics 2001;10(21):2353-61.
2001: Stuart A Nicklin; Hildegard Buening; Kate L Dishart; Mahesh De Alwis; A Girod; Ulrich T Hacker; Adrian J Thrasher; Robin R Ali; Michael Hallek; Andrew H Baker
Efficient and selective AAV2-mediated gene transfer directed to human vascular endothelial cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;4(3):174-81.
2001: Siobhan Burns; Adrian J Thrasher; Michael P Blundell; L Machesky; Gareth E Jones
Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation.
Blood 2001;98(4):1142-9.
2001: E Feudner; Mahesh De Alwis; Adrian J Thrasher; Robin R Ali; S Fauser
Optimization of recombinant adeno-associated virus production using an herpes simplex virus amplicon system.
Journal of virological methods 2001;96(2):97-105.
2001: Waseem Qasim; Kimberly C Gilmour; S Heath; E Ashton; T Cranston; A Thomas; A Finn; E Graham Davies; Adrian J Thrasher; Christine Kinnon; Alison Jones; H Bobby Gaspar
Protein assays for diagnosis of Wiskott-Aldrich syndrome and X-linked thrombocytopenia.
British journal of haematology 2001;113(4):861-5.
2001: MJ Wright; LM Wightman; Caroline E Lilley; Mahesh De Alwis; Stephen Hart; A Miller; Robert S Coffin; Adrian J Thrasher; David S Latchman; Michael S Marber
In vivo myocardial gene transfer: optimization, evaluation and direct comparison of gene transfer vectors.
Basic research in cardiology 2001;96(3):227-36.
2001: Yann Leverrier; R Lorenzi; Michael P Blundell; PM Brickell; Christine Kinnon; Anne J Ridley; Adrian J Thrasher
Cutting edge: the Wiskott-Aldrich syndrome protein is required for efficient phagocytosis of apoptotic cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(8):4831-4.
2001: Caroline J Marshall; Adrian J Thrasher
The embryonic origins of human haematopoiesis.
British journal of haematology 2001;112(4):838-50.
2001: Martin B Reichel; J W B Bainbridge; D Baker; Adrian J Thrasher; Shomi S Bhattacharya; Robin R Ali
An immune response after intraocular administration of an adenoviral vector containing a beta galactosidase reporter gene slows retinal degeneration in the rd mouse.
The British journal of ophthalmology 2001;85(3):341-4.
2000: Adrian J Thrasher; Siobhan Burns; R Lorenzi; Gareth E Jones
The Wiskott-Aldrich syndrome: disordered actin dynamics in haematopoietic cells.
Immunological reviews 2000;178():118-28.
2000: Caroline J Marshall; Christine Kinnon; Adrian J Thrasher
Polarized expression of bone morphogenetic protein-4 in the human aorta-gonad-mesonephros region.
Blood 2000;96(4):1591-3.
2000: Robin R Ali; Gian-Marco Sarra; Clare Stephens; M D Alwis; J W B Bainbridge; Peter M G Munro; S Fauser; Martin B Reichel; Christine Kinnon; David Hunt; Shomi S Bhattacharya; Adrian J Thrasher
Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy.
Nature genetics 2000;25(3):306-10.
2000: Kimberly C Gilmour; T Cranston; Alison Jones; E Graham Davies; David Goldblatt; Adrian J Thrasher; Christine Kinnon; K E Nichols; H Bobby Gaspar
Diagnosis of X-linked lymphoproliferative disease by analysis of SLAM-associated protein expression.
European journal of immunology 2000;30(6):1691-7.
2000: R Lorenzi; PM Brickell; David R Katz; Christine Kinnon; Adrian J Thrasher
Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis.
Blood 2000;95(9):2943-6.
2000: Adrian J Thrasher; Christine Kinnon
The Wiskott-Aldrich syndrome.
Clinical and experimental immunology 2000;120(1):2-9.
2000: H White; Adrian J Thrasher; P Veys; Christine Kinnon; H Bobby Gaspar
Intrinsic defects of B cell function in X-linked severe combined immunodeficiency.
European journal of immunology 2000;30(3):732-7.
2000: Christophe Demaison; Gaby Brouns; Michael P Blundell; Jacki Goldman; Roland J Levinsky; Manuel Grez; Christine Kinnon; Adrian J Thrasher
A defined window for efficient gene marking of severe combined immunodeficient-repopulating cells using a gibbon ape leukemia virus-pseudotyped retroviral vector.
Human gene therapy 2000;11(1):91-100.
1999: Michael P Blundell; Christophe Demaison; Gaby Brouns; Jacki Goldman; H Bobby Gaspar; Christine Kinnon; Adrian J Thrasher; Lorenza Lazzari; Girolamo Sirchia
Quality of repopulation in nonobese diabetic severe combined immunodeficient mice engrafted with expanded cord blood CD34+ cells.
Blood 1999;94(9):3269-70.
1999: Adrian J Thrasher; Siobhan Burns
Wiskott-Aldrich syndrome: a disorder of haematopoietic cytoskeletal regulation.
Microscopy research and technique 1999;47(2):107-13.
1999: X Zhang; Mahesh De Alwis; Stephen Hart; F W Fitzke; SC Inglis; ME Boursnell; Roland J Levinsky; Christine Kinnon; Robin R Ali; Adrian J Thrasher
High-titer recombinant adeno-associated virus production from replicating amplicons and herpes vectors deleted for glycoprotein H.
Human gene therapy 1999;10(15):2527-37.
1999: E Graham Davies; Adrian J Thrasher; K Lacey; J Harper
Topical cidofovir for severe molluscum contagiosum.
Lancet 1999;353(9169):2042.
1999: Caroline J Marshall; R L Moore; Peter Thorogood; PM Brickell; Christine Kinnon; Adrian J Thrasher
Detailed characterization of the human aorta-gonad-mesonephros region reveals morphological polarity resembling a hematopoietic stromal layer.
Developmental dynamics : an official publication of the American Association of Anatomists 1999;215(2):139-47.
1999: David Goldblatt; J Butcher; Adrian J Thrasher; Isabelle Russell-Eggitt
Chorioretinal lesions in patients and carriers of chronic granulomatous disease.
The Journal of pediatrics 1999;134(6):780-3.
1998: Adrian J Thrasher; Gareth E Jones; Christine Kinnon; PM Brickell; David R Katz
Is Wiskott--Aldrich syndrome a cell trafficking disorder?
Immunology today 1998;19(12):537-9.
1998: J Povey; N Weeratunge; Chloe M Marden; A Sehgal; Adrian J Thrasher; Colin Casimir
Enhanced retroviral transduction of 5-fluorouracil-resistant human bone marrow (stem) cells using a genetically modified packaging cell line.
Blood 1998;92(11):4080-9.
1998: Robin R Ali; Martin B Reichel; AP Byrnes; C J Stephens; Adrian J Thrasher; David Baker; David Hunt; Shomi S Bhattacharya
Co-injection of adenovirus expressing CTLA4-Ig prolongs adenovirally mediated lacZ reporter gene expression in the mouse retina.
Gene therapy 1998;5(11):1561-5.
1998: Jacki Goldman; Michael P Blundell; L Lopes; Christine Kinnon; J P Di Santo; Adrian J Thrasher
Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor gamma chain.
British journal of haematology 1998;103(2):335-42.
1998: Andrea Schilz; Gaby Brouns; H Knöss; Oliver G Ottmann; Dieter Hoelzer; Axel A Fauser; Adrian J Thrasher; Manuel Grez
High efficiency gene transfer to human hematopoietic SCID-repopulating cells under serum-free conditions.
Blood 1998;92(9):3163-71.
1998: Michael Binks; Gareth E Jones; PM Brickell; Christine Kinnon; David R Katz; Adrian J Thrasher
Intrinsic dendritic cell abnormalities in Wiskott-Aldrich syndrome.
European journal of immunology 1998;28(10):3259-67.
1998: Martin B Reichel; Robin R Ali; Adrian J Thrasher; David Hunt; Shomi S Bhattacharya; David Baker
Immune responses limit adenovirally mediated gene expression in the adult mouse eye.
Gene therapy 1998;5(8):1038-46.
1998: Daniel Zicha; William E Allen; PM Brickell; Christine Kinnon; Graham A Dunn; Gareth E Jones; Adrian J Thrasher
Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome.
British journal of haematology 1998;101(4):659-65.
1998: PM Brickell; David R Katz; Adrian J Thrasher
Wiskott-Aldrich syndrome: current research concepts.
British journal of haematology 1998;101(4):603-8.
1998: Robert S Coffin; SK Thomas; N Shaun B Thomas; Caroline E Lilley; Arnold Pizzey; C H Griffiths; Barry J Gibb; MJ Wagstaff; S J Inges; Michael Binks; Benjamin M Chain; Adrian J Thrasher; Karine Rutault; David S Latchman
Pure populations of transduced primary human cells can be produced using GFP expressing herpes virus vectors and flow cytometry.
Gene therapy 1998;5(5):718-22.
1998: Stephen Hart; Carolina V Arancibia-Cárcamo; MA Wolfert; Carolina Mailhos; N J O'Reilly; Robin R Ali; Charles Coutelle; A J George; Richard P Harbottle; A M Knight; D F Larkin; Roland J Levinsky; L W Seymour; Adrian J Thrasher; Christine Kinnon
Lipid-mediated enhancement of transfection by a nonviral integrin-targeting vector.
Human gene therapy 1998;9(4):575-85.
1998: Robin R Ali; Martin B Reichel; Mahesh De Alwis; Naheed Kanuga; Christine Kinnon; Roland J Levinsky; David Hunt; Shomi S Bhattacharya; Adrian J Thrasher
Adeno-associated virus gene transfer to mouse retina.
Human gene therapy 1998;9(1):81-6.
1997: Adrian J Thrasher; J Goldman; Mahesh De Alwis; C D Porter; Christine Kinnon
Gene therapy for primary immunodeficiency.
Biochemical Society transactions 1997;25(2):537-40.
1996: Robin R Ali; Martin B Reichel; Adrian J Thrasher; Roland J Levinsky; Christine Kinnon; Naheed Kanuga; David Hunt; Shomi S Bhattacharya
Gene transfer into the mouse retina mediated by an adeno-associated viral vector.
Human molecular genetics 1996;5(5):591-4.
1995: Adrian J Thrasher; C Kinnon
Gene therapy for primary immunodeficiency.
Gene therapy 1995;2(9):601-2.
1995: Adrian J Thrasher; Mahesh De Alwis; Colin Casimir; Christine Kinnon; K Page; J Lebkowski; Anthony W Segal; Roland J Levinsky
Generation of recombinant adeno-associated virus (rAAV) from an adenoviral vector and functional reconstitution of the NADPH-oxidase.
Gene therapy 1995;2(7):481-5.
1995: Adrian J Thrasher; Mahesh De Alwis; Colin Casimir; Christine Kinnon; K Page; J Lebkowski; Anthony W Segal; Roland J Levinsky
Functional reconstitution of the NADPH-oxidase by adeno-associated virus gene transfer.
Blood 1995;86(2):761-5.
1995: Adrian J Thrasher; Colin Casimir; Christine Kinnon; G Morgan; Anthony W Segal; Roland J Levinsky
Gene transfer to primary chronic granulomatous disease monocytes.
Lancet 1995;346(8967):92-3.
1995: M Chetty; Adrian J Thrasher; A Abo; Colin Casimir
Low NADPH oxidase activity in Epstein-Barr-virus-immortalized B-lymphocytes is due to a post-transcriptional block in expression of cytochrome b558.
The Biochemical journal 1995;306 ( Pt 1)():141-5.
1995: Michael Levin; M J Newport; S D'Souza; P Kalabalikis; I N Brown; H M Lenicker; P V Agius; E G Davies; Adrian J Thrasher; N Klein
Familial disseminated atypical mycobacterial infection in childhood: a human mycobacterial susceptibility gene?
Lancet 1995;345(8942):79-83.
1994: Adrian J Thrasher; N H Keep; Frans B Wientjes; Anthony W Segal
Chronic granulomatous disease.
Biochimica et biophysica acta 1994;1227(1-2):1-24.
1993: Adrian J Thrasher; A Segal; Colin Casimir
Chronic granulomatous disease: towards gene therapy.
Immunodeficiency 1993;4(1-4):327-33.
1992: Adrian J Thrasher; M Chetty; Colin Casimir; Anthony W Segal
Restoration of superoxide generation to a chronic granulomatous disease-derived B-cell line by retrovirus mediated gene transfer.
Blood 1992;80(5):1125-9.
1992: A Abo; A Boyhan; I West; Adrian J Thrasher; Anthony W Segal
Reconstitution of neutrophil NADPH oxidase activity in the cell-free system by four components: p67-phox, p47-phox, p21rac1, and cytochrome b-245.
The Journal of biological chemistry 1992;267(24):16767-70.