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Adrian Thrasher
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46
Kinnon, Christine
30
Ali, Robin
29
Gaspar, Bobby
18
Jones, Gareth
16
Howe, Steven
16
Blundell, Michael
15
Bainbridge, J W B
14
De Alwis, Mahesh
11
Gilmour, Kimberly
10
Qasim, Waseem
10
Sinclair, Joanna
9
Smith, Alexander
9
von Kalle, Christof
9
Levinsky, Roland
9
Mistry, Ajay
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All Publications
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2009: Wu Yin; Wu Wutian; Wong Wai Man; Ward Eliot; Thrasher Adrian J; Goldblatt David; Osman Mohamed; Digard Paul; Canaday David H; Gustafsson Kenth
Human gammadelta T cells: a lymphoid lineage cell capable of professional phagocytosis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(9):5622-9.
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2009: Qasim W; Gaspar H B; Thrasher A J
Progress and prospects: gene therapy for inherited immunodeficiencies.
Gene therapy 2009;16(11):1285-91.
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2009: Modlich Ute; Navarro Susana; Zychlinski Daniela; Maetzig Tobias; Knoess Sabine; Brugman Martijn H; Schambach Axel; Charrier Sabine; Galy Anne; Thrasher Adrian J; Bueren Juan; Baum Christopher
Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(11):1919-28.
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2009: Bouma Gerben; Doffinger Rainer; Patel Smita Y; Peskett Emma; Sinclair Joanna C; Barcenas-Morales Gabriela; Cerron-Gutierrez Lourdes; Kumararatne Dinakantha S; Davies E Graham; Thrasher Adrian J; Burns Siobhan O
Impaired neutrophil migration and phagocytosis in IRAK-4 deficiency.
British journal of haematology 2009;147(1):153-6.
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2009: Blundell Michael P; Bouma Gerben; Metelo Joao; Worth Austen; Calle Yolanda; Cowell Lucy A; Westerberg Lisa S; Moulding Dale A; Mirando Samuel; Kinnon Christine; Cory Giles O; Jones Gareth E; Snapper Scott B; Burns Siobhan O; Thrasher Adrian J
Phosphorylation of WASp is a key regulator of activity and stability in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(37):15738-43.
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2009: Vink Conrad A; Gaspar H Bobby; Gabriel Richard; Schmidt Manfred; McIvor R Scott; Thrasher Adrian J; Qasim Waseem
Sleeping beauty transposition from nonintegrating lentivirus.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(7):1197-204.
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2009: Scobie Linda; Hector Ralph D; Grant Louise; Bell Margaret; Nielsen Anne A; Meikle Sharon; Philbey Adrian; Thrasher Adrian J; Cameron Ewan R; Blyth Karen; Neil James C
A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of gammaC gene oncogenicity.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(6):1031-8.
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2009: Rahim A A; Wong A M S; Howe S J; Buckley S M K; Acosta-Saltos A D; Elston K E; Ward N J; Philpott N J; Cooper J D; Anderson P N; Waddington S N; Thrasher A J; Raivich G
Efficient gene delivery to the adult and fetal CNS using pseudotyped non-integrating lentiviral vectors.
Gene therapy 2009;16(4):509-20.
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2009: Moreno-Carranza B; Gentsch M; Stein S; Schambach A; Santilli G; Rudolf E; Ryser M F; Haria S; Thrasher A J; Baum C; Brenner S; Grez M
Transgene optimization significantly improves SIN vector titers, gp91phox expression and reconstitution of superoxide production in X-CGD cells.
Gene therapy 2009;16(1):111-8.
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2009: Bouma Gerben; Burns Siobhan O; Thrasher Adrian J
Wiskott-Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activation.
Immunobiology 2009;214(9-10):778-90.
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2008: Himoudi Nourredine; Nabarro Stephen; Buddle Jo; Eddaoudi Ayad; Thrasher Adrian J; Anderson John
Bone marrow-derived IFN-producing killer dendritic cells account for the tumoricidal activity of unpulsed dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):6654-63.
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2008: Buckley Suzanne M K; Howe Steven J; Rahim Ahad A; Buning Hildegard; McIntosh Jenny; Wong Suet-Ping; Baker Andrew H; Nathwani Amit; Thrasher Adrian J; Coutelle Charles; McKay Tristan R; Waddington Simon N
Luciferin detection after intranasal vector delivery is improved by intranasal rather than intraperitoneal luciferin administration.
Human gene therapy 2008;19(10):1050-6.
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2008: Calle Y; Antón I M; Thrasher A J; Jones G E
WASP and WIP regulate podosomes in migrating leukocytes.
Journal of microscopy 2008;231(3):494-505.
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2008: Howe Steven J; Mansour Marc R; Schwarzwaelder Kerstin; Bartholomae Cynthia; Hubank Michael; Kempski Helena; Brugman Martijn H; Pike-Overzet Karin; Chatters Stephen J; de Ridder Dick; Gilmour Kimberly C; Adams Stuart; Thornhill Susannah I; Parsley Kathryn L; Staal Frank J T; Gale Rosemary E; Linch David C; Bayford Jinhua; Brown Lucie; Quaye Michelle; Kinnon Christine; Ancliff Philip; Webb David K; Schmidt Manfred; von Kalle Christof; Gaspar H Bobby; Thrasher Adrian J
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients.
The Journal of clinical investigation 2008;118(9):3143-50.
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2008: Buckley S M K; Howe S J; Sheard V; Ward N J; Coutelle C; Thrasher A J; Waddington S N; McKay T R
Lentiviral transduction of the murine lung provides efficient pseudotype and developmental stage-dependent cell-specific transgene expression.
Gene therapy 2008;15(16):1167-75.
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2008: Bainbridge James W B; Smith Alexander J; Barker Susie S; Robbie Scott; Henderson Robert; Balaggan Kamaljit; Viswanathan Ananth; Holder Graham E; Stockman Andrew; Tyler Nick; Petersen-Jones Simon; Bhattacharya Shomi S; Thrasher Adrian J; Fitzke Fred W; Carter Barrie J; Rubin Gary S; Moore Anthony T; Ali Robin R
Effect of gene therapy on visual function in Leber's congenital amaurosis.
The New England journal of medicine 2008;358(21):2231-9.
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2008: Thrasher Adrian J
Gene therapy for primary immunodeficiencies.
Immunology and allergy clinics of North America 2008;28(2):457-71, xi.
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2008: Blundell Michael P; Bouma Gerben; Calle Yolanda; Jones Gareth E; Kinnon Christine; Thrasher Adrian J
Improvement of migratory defects in a murine model of Wiskott-Aldrich syndrome gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(5):836-44.
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2008: Thornhill Susannah I; Schambach Axel; Howe Steven J; Ulaganathan Meera; Grassman Elke; Williams David; Schiedlmeier Bernhard; Sebire Neil J; Gaspar H Bobby; Kinnon Christine; Baum Christopher; Thrasher Adrian J
Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodeficiency.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(3):590-8.
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2007: Laurie K L; Blundell M P; Baxendale H E; Howe S J; Sinclair J; Qasim W; Brunsberg U; Thrasher A J; Holmdahl R; Gustafsson K
Cell-specific and efficient expression in mouse and human B cells by a novel hybrid immunoglobulin promoter in a lentiviral vector.
Gene therapy 2007;14(23):1623-31.
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2007: Qasim Waseem; Gaspar H Bobby; Thrasher Adrian J
Update on clinical gene therapy in childhood.
Archives of disease in childhood 2007;92(11):1028-31.
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2007: Apolonia Luis; Waddington Simon N; Fernandes Carolina; Ward Natalie J; Bouma Gerben; Blundell Michael P; Thrasher Adrian J; Collins Mary K; Philpott Nicola J
Stable gene transfer to muscle using non-integrating lentiviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(11):1947-54.
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2007: Marshall Caroline J; Sinclair Joanna C; Thrasher Adrian J; Kinnon Christine
Bone morphogenetic protein 4 modulates c-Kit expression and differentiation potential in murine embryonic aorta-gonad-mesonephros haematopoiesis in vitro.
British journal of haematology 2007;139(2):321-30.
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2007: Moulding Dale A; Blundell Michael P; Spiller David G; White Michael R H; Cory Giles O; Calle Yolanda; Kempski Helena; Sinclair Jo; Ancliff Phil J; Kinnon Christine; Jones Gareth E; Thrasher Adrian J
Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia.
The Journal of experimental medicine 2007;204(9):2213-24.
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2007: Bacchelli C; Buckridge S; Thrasher A J; Gaspar H B
Translational mini-review series on immunodeficiency: molecular defects in common variable immunodeficiency.
Clinical and experimental immunology 2007;149(3):401-9.
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2007: Cattoglio Claudia; Facchini Giulia; Sartori Daniela; Antonelli Antonella; Miccio Annarita; Cassani Barbara; Schmidt Manfred; von Kalle Christof; Howe Steve; Thrasher Adrian J; Aiuti Alessandro; Ferrari Giuliana; Recchia Alessandra; Mavilio Fulvio
Hot spots of retroviral integration in human CD34+ hematopoietic cells.
Blood 2007;110(6):1770-8.
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2007: Zhang Fang; Thornhill Susannah I; Howe Steven J; Ulaganathan Meera; Schambach Axel; Sinclair Joanna; Kinnon Christine; Gaspar H Bobby; Antoniou Michael; Thrasher Adrian J
Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells.
Blood 2007;110(5):1448-57.
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2007: Himoudi Nourredine; Nabarro Steven; Yan Mengyong; Gilmour Kimberly; Thrasher Adrian J; Anderson John
Development of anti-PAX3 immune responses; a target for cancer immunotherapy.
Cancer immunology, immunotherapy : CII 2007;56(9):1381-95.
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2007: Schwarzwaelder Kerstin; Howe Steven J; Schmidt Manfred; Brugman Martijn H; Deichmann Annette; Glimm Hanno; Schmidt Sonja; Prinz Claudia; Wissler Manuela; King Douglas J S; Zhang Fang; Parsley Kathryn L; Gilmour Kimberly C; Sinclair Joanna; Bayford Jinhua; Peraj Rachel; Pike-Overzet Karin; Staal Frank J T; de Ridder Dick; Kinnon Christine; Abel Ulrich; Wagemaker Gerard; Gaspar H Bobby; Thrasher Adrian J; von Kalle Christof
Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo.
The Journal of clinical investigation 2007;117(8):2241-9.
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2007: Barker S E; Grosse S M; Siapati E K; Kritz A; Kinnon C; Thrasher A J; Hart S L
Immunotherapy for neuroblastoma using syngeneic fibroblasts transfected with IL-2 and IL-12.
British journal of cancer 2007;97(2):210-7.
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2007: Kim J J; Thrasher A J; Jones A M; Davies E G; Cale C M
Rituximab for the treatment of autoimmune cytopenias in children with immune deficiency.
British journal of haematology 2007;138(1):94-6.
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2007: Salzer Ulrich; Birmelin Jennifer; Bacchelli Chiara; Witte Torsten; Buchegger-Podbielski Ulrike; Buckridge Sylvie; Rzepka Rita; Gaspar H Bobby; Thrasher Adrian J; Schmidt Reinhold E; Melchers Inga; Grimbacher Bodo
Sequence analysis of TNFRSF13b, encoding TACI, in patients with systemic lupus erythematosus.
Journal of clinical immunology 2007;27(4):372-7.
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2007: Philpott Nicola J; Thrasher Adrian J
Use of nonintegrating lentiviral vectors for gene therapy.
Human gene therapy 2007;18(6):483-9.
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2007: Siapati Elena K; Bigger Brian W; Kashofer Karl; Themis Mike; Thrasher Adrian J; Bonnet Dominique
Murine leukemia following irradiation conditioning for transplantation of lentivirally-modified hematopoietic stem cells.
European journal of haematology 2007;78(4):303-13.
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2007: Pike-Overzet K; de Ridder D; Weerkamp F; Baert M R M; Verstegen M M A; Brugman M H; Howe S J; Reinders M J T; Thrasher A J; Wagemaker G; van Dongen J J M; Staal F J T
Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007;21(4):754-63.
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2007: Qasim Waseem; Mackey Taylor; Sinclair Jo; Chatziandreou Ilenia; Kinnon Christine; Thrasher Adrian J; Gaspar H Bobby
Lentiviral vectors for T-cell suicide gene therapy: preservation of T-cell effector function after cytokine-mediated transduction.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(2):355-60.
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2007: Abel Ulrich; Deichmann Annette; Bartholomae Cynthia; Schwarzwaelder Kerstin; Glimm Hanno; Howe Steven; Thrasher Adrian; Garrigue Alexandrine; Hacein-Bey-Abina Salima; Cavazzana-Calvo Marina; Fischer Alain; Jaeger Dirk; von Kalle Christof; Schmidt Manfred
Real-time definition of non-randomness in the distribution of genomic events.
PloS one 2007;2(6):e570.
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2006: Chou Hsiu-Chuan; Antón Inés M; Holt Mark R; Curcio Claudia; Lanzardo Stefania; Worth Austen; Burns Siobhan; Thrasher Adrian J; Jones Gareth E; Calle Yolanda
WIP regulates the stability and localization of WASP to podosomes in migrating dendritic cells.
Current biology : CB 2006;16(23):2337-44.
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2006: Booth Claire; Ribeil Jean-Antoine; Audat Françoise; Dal-Cortivo Liliane; Veys Paul A; Thrasher Adrian J; Davies E Graham; Lefrère François; Fischer Alain; Cavazzana-Calvo Marina; Gaspar H Bobby
CD34 stem cell top-ups without conditioning after initial haematopoietic stem cell transplantation for correction of incomplete haematopoietic and immunological recovery in severe congenital immunodeficiencies.
British journal of haematology 2006;135(4):533-7.
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2006: Gaspar H Bobby; Bjorkegren Emma; Parsley Kate; Gilmour Kimberly C; King Doug; Sinclair Joanna; Zhang Fang; Giannakopoulos Aris; Adams Stuart; Fairbanks Lynette D; Gaspar Jane; Henderson Lesley; Xu-Bayford Jin Hua; Davies E Graham; Veys Paul A; Kinnon Christine; Thrasher Adrian J
Successful reconstitution of immunity in ADA-SCID by stem cell gene therapy following cessation of PEG-ADA and use of mild preconditioning.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(4):505-13.
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2006: Ancliff Phil J; Blundell Michael P; Cory Giles O; Calle Yolanda; Worth Austen; Kempski Helena; Burns Siobhan; Jones Gareth E; Sinclair Jo; Kinnon Christine; Hann Ian M; Gale Rosemary E; Linch David C; Thrasher Adrian J
Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia.
Blood 2006;108(7):2182-9.
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2006: Pike-Overzet Karin; de Ridder Dick; Weerkamp Floor; Baert Miranda R M; Verstegen Monique M; Brugman Martijn H; Howe Steven J; Reinders Marcel J T; Thrasher Adrian J; Wagemaker Gerard; van Dongen Jacques J M; Staal Frank J T
Gene therapy: is IL2RG oncogenic in T-cell development?
Nature 2006;443(7109):E5; discussion E6-7.
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2006: Thrasher Adrian J; Gaspar H Bobby; Baum Christopher; Modlich Ute; Schambach Axel; Candotti Fabio; Otsu Makoto; Sorrentino Brian; Scobie Linda; Cameron Ewan; Blyth Karen; Neil Jim; Abina Salima Hacein-Bey; Cavazzana-Calvo Marina; Fischer Alain
Gene therapy: X-SCID transgene leukaemogenicity.
Nature 2006;443(7109):E5-6; discussion E6-7.
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2006: Calle Yolanda; Carragher Neil O; Thrasher Adrian J; Jones Gareth E
Inhibition of calpain stabilises podosomes and impairs dendritic cell motility.
Journal of cell science 2006;119(Pt 11):2375-85.
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2006: Fabes Jez; Anderson Patrick; Yáñez-Muñoz Rafael J; Thrasher Adrian; Brennan Caroline; Bolsover Stephen
Accumulation of the inhibitory receptor EphA4 may prevent regeneration of corticospinal tract axons following lesion.
The European journal of neuroscience 2006;23(7):1721-30.
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2006: Worth Austen; Thrasher Adrian J; Gaspar H Bobby
Autoimmune lymphoproliferative syndrome: molecular basis of disease and clinical phenotype.
British journal of haematology 2006;133(2):124-40.
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2006: Ott Marion G; Schmidt Manfred; Schwarzwaelder Kerstin; Stein Stefan; Siler Ulrich; Koehl Ulrike; Glimm Hanno; Kühlcke Klaus; Schilz Andrea; Kunkel Hana; Naundorf Sonja; Brinkmann Andrea; Deichmann Annette; Fischer Marlene; Ball Claudia; Pilz Ingo; Dunbar Cynthia; Du Yang; Jenkins Nancy A; Copeland Neal G; Lüthi Ursula; Hassan Moustapha; Thrasher Adrian J; Hoelzer Dieter; von Kalle Christof; Seger Reinhard; Grez Manuel
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.
Nature medicine 2006;12(4):401-9.
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2006: Calle Yolanda; Burns Siobhan; Thrasher Adrian J; Jones Gareth E
The leukocyte podosome.
European journal of cell biology 2006;85(3-4):151-7.
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2006: Yáñez-Muñoz Rafael J; Balaggan Kamaljit S; MacNeil Angus; Howe Steven J; Schmidt Manfred; Smith Alexander J; Buch Prateek; MacLaren Robert E; Anderson Patrick N; Barker Susie E; Duran Yanai; Bartholomae Cynthia; von Kalle Christof; Heckenlively John R; Kinnon Christine; Ali Robin R; Thrasher Adrian J
Effective gene therapy with nonintegrating lentiviral vectors.
Nature medicine 2006;12(3):348-53.
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2006: Bigger B W; Siapati E K; Mistry A; Waddington S N; Nivsarkar M S; Jacobs L; Perrett R; Holder M V; Ridler C; Kemball-Cook G; Ali R R; Forbes S J; Coutelle C; Wright N; Alison M; Thrasher A J; Bonnet D; Themis M
Permanent partial phenotypic correction and tolerance in a mouse model of hemophilia B by stem cell gene delivery of human factor IX.
Gene therapy 2006;13(2):117-26.
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2005: Nabarro Stephen; Himoudi Nourredine; Papanastasiou Antigoni; Gilmour Kimberly; Gibson Sian; Sebire Neil; Thrasher Adrian; Blundell Michael P; Hubank Mike; Canderan Glenda; Anderson John
Coordinated oncogenic transformation and inhibition of host immune responses by the PAX3-FKHR fusion oncoprotein.
The Journal of experimental medicine 2005;202(10):1399-410.
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2005: Xue Shao-An; Gao Liquan; Hart Daniel; Gillmore Roopinder; Qasim Waseem; Thrasher Adrian; Apperley Jane; Engels Boris; Uckert Wolfgang; Morris Emma; Stauss Hans
Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene-transduced human T cells.
Blood 2005;106(9):3062-7.
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2005: Themis Mike; Waddington Simon N; Schmidt Manfred; von Kalle Christof; Wang Yoahe; Al-Allaf Faisal; Gregory Lisa G; Nivsarkar Megha; Themis Matthew; Holder Maxine V; Buckley Suzanne M K; Dighe Niraja; Ruthe Alaine T; Mistry Ajay; Bigger Brian; Rahim Ahad; Nguyen Tuan H; Trono Didier; Thrasher Adrian J; Coutelle Charles
Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(4):763-71.
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2005: Gaspar H Bobby; Thrasher Adrian J
Gene therapy for severe combined immunodeficiencies.
Expert opinion on biological therapy 2005;5(9):1175-82.
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2005: Siapati Elena K; Bigger Brian W; Miskin James; Chipchase Daniel; Parsley Kathryn L; Mitrophanous Kyriacos; Themis Mike; Thrasher Adrian J; Bonnet Dominique
Comparison of HIV- and EIAV-based vectors on their efficiency in transducing murine and human hematopoietic repopulating cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(3):537-46.
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2005: Broderick Cathryn A; Smith Alexander J; Balaggan Kam S; Georgiadis Anastasios; Buch Prateek K; Trittibach Peter C; Barker Susie E; Sarra Gian-Marco; Thrasher Adrian J; Dick Andrew D; Ali Robin R
Local administration of an adeno-associated viral vector expressing IL-10 reduces monocyte infiltration and subsequent photoreceptor damage during experimental autoimmune uveitis.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(2):369-73.
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2005: Thrasher Adrian J; Gaspar H Bobby
Gene therapy for lympho-hematopoietic disorders.
Current hematology reports 2005;4(4):305-9.
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2005: Thrasher Adrian J; Hacein-Bey-Abina Salima; Gaspar H Bobby; Blanche Stephane; Davies E Graham; Parsley Kathryn; Gilmour Kimberly; King Douglas; Howe Steven; Sinclair Joanna; Hue Christophe; Carlier Frédérique; von Kalle Christof; de Saint Basile Geneviève; le Deist Françoise; Fischer Alain; Cavazzana-Calvo Marina
Failure of SCID-X1 gene therapy in older patients.
Blood 2005;105(11):4255-7.
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2005: Tschernutter M; Schlichtenbrede F C; Howe S; Balaggan K S; Munro P M; Bainbridge J W B; Thrasher A J; Smith A J; Ali R R
Long-term preservation of retinal function in the RCS rat model of retinitis pigmentosa following lentivirus-mediated gene therapy.
Gene therapy 2005;12(8):694-701.
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2005: Qasim W; Gaspar H B; Thrasher A J
T cell suicide gene therapy to aid haematopoietic stem cell transplantation.
Current gene therapy 2005;5(1):121-32.
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2005: de Noronha Sofia; Hardy Samantha; Sinclair Joanna; Blundell Michael P; Strid Jessica; Schulz Oliver; Zwirner Jörg; Jones Gareth E; Katz David R; Kinnon Christine; Thrasher Adrian J
Impaired dendritic-cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein.
Blood 2005;105(4):1590-7.
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2004: Gaspar H Bobby; Parsley Kathryn L; Howe Steven; King Doug; Gilmour Kimberly C; Sinclair Joanna; Brouns Gaby; Schmidt Manfred; Von Kalle Christof; Barington Torben; Jakobsen Marianne A; Christensen Hans O; Al Ghonaium Abdulaziz; White Harry N; Smith John L; Levinsky Roland J; Ali Robin R; Kinnon Christine; Thrasher Adrian J
Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector.
Lancet 2004;364(9452):2181-7.
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2004: Burns Siobhan; Cory Giles O; Vainchenker William; Thrasher Adrian J
Mechanisms of WASp-mediated hematologic and immunologic disease.
Blood 2004;104(12):3454-62.
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2004: Burns S; Thrasher A J
Dendritic cells: the bare bones of immunity.
Current biology : CB 2004;14(22):R965-7.
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2004: Calle Yolanda; Chou Hsiu-Chuan; Thrasher Adrian J; Jones Gareth E
Wiskott-Aldrich syndrome protein and the cytoskeletal dynamics of dendritic cells.
The Journal of pathology 2004;204(4):460-9.
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2004: Waddington Simon N; Nivsarkar Megha S; Mistry Ajay R; Buckley Suzanne M K; Kemball-Cook Geoffrey; Mosley Karen L; Mitrophanous Kyriacos; Radcliffe Pippa; Holder Maxine V; Brittan Mairi; Georgiadis Anastasios; Al-Allaf Faisal; Bigger Brian W; Gregory Lisa G; Cook H Terence; Ali Robin R; Thrasher Adrian; Tuddenham Edward G D; Themis Mike; Coutelle Charles
Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy.
Blood 2004;104(9):2714-21.
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2004: Qasim Waseem; Gaspar H Bobby; Thrasher Adrian J
Gene therapy for severe combined immune deficiency.
Expert reviews in molecular medicine 2004;6(13):1-15.
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2004: Schwickerath Oliver; Brouns Gaby; Thrasher Adrian; Kinnon Christine; Roes Jürgen; Casimir Colin
Enhancer-deleted retroviral vectors restore high levels of superoxide generation in a mouse model of CGD.
The journal of gene medicine 2004;6(6):603-15.
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2004: Booth M J; Mistry A; Li X; Thrasher A; Coffin R S
Transfection-free and scalable recombinant AAV vector production using HSV/AAV hybrids.
Gene therapy 2004;11(10):829-37.
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2004: Calle Yolanda; Jones Gareth E; Jagger Chris; Fuller Karen; Blundell Mike P; Chow Jade; Chambers Tim; Thrasher Adrian J
WASp deficiency in mice results in failure to form osteoclast sealing zones and defects in bone resorption.
Blood 2004;103(9):3552-61.
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2004: Sharifi Reza; Sinclair Joanna C; Gilmour Kimberly C; Arkwright Peter D; Kinnon Christine; Thrasher Adrian J; Gaspar H Bobby
SAP mediates specific cytotoxic T-cell functions in X-linked lymphoproliferative disease.
Blood 2004;103(10):3821-7.
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2004: Ahmed Forhad; Ings Stuart J; Pizzey Arnold R; Blundell Michael P; Thrasher Adrian J; Ye Hong T; Fahey Anne; Linch David C; Yong Kwee L
Impaired bone marrow homing of cytokine-activated CD34+ cells in the NOD/SCID model.
Blood 2004;103(6):2079-87.
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2004: Burns Siobhan; Hardy Samantha J; Buddle Joanna; Yong Kwee L; Jones Gareth E; Thrasher Adrian J
Maturation of DC is associated with changes in motile characteristics and adherence.
Cell motility and the cytoskeleton 2004;57(2):118-32.
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2004: Schlichtenbrede F C; Smith A J; Bainbridge J W B; Thrasher A J; Salt T E; Ali R R
Improvement of neuronal visual responses in the superior colliculus in Prph2(Rd2/Rd2) mice following gene therapy.
Molecular and cellular neurosciences 2004;25(1):103-10.
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2004: Thrasher Adrian J; Edwards Robert G
Averting abnormal inheritance: potential of gene therapy and preimplantation diagnosis.
Reproductive biomedicine online 2004;8(1):99-106.
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2003: Uduehi Aima; Mailhos Carolina; Truman Hazel; Thrasher Adrian J; Kinnon Christine; Hart Stephen L
Enhancement of integrin-mediated transfection of haematopoietic cells with a synthetic vector system.
Biotechnology and applied biochemistry 2003;38(Pt 3):201-9.
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2003: Marden Chloe; Cunninghame Graham Deborah; Thrasher Adrian; Casimir Colin
A functional ISRE is required for myeloid transcription of the p47(phox) gene.
Biochimica et biophysica acta 2003;1630(2-3):117-22.
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2003: Qasim Waseem; King Douglas; Buddle Jo; Verfuerth Stephanie; Kinnon Christine; Thrasher Adrian J; Gaspar Hubert B
The impact of retroviral suicide gene transduction procedures on T cells.
British journal of haematology 2003;123(4):712-9.
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2003: Gaspar H B; Howe S; Thrasher A J
Gene therapy progress and prospects: gene therapy for severe combined immunodeficiency.
Gene therapy 2003;10(24):1999-2004.
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2003: Schlichtenbrede Frank C; da Cruz Lyndon; Stephens Clare; Smith Alexander J; Georgiadis Anastasios; Thrasher Adrian J; Bainbridge James W B; Seeliger Mathias W; Ali Robin R
Long-term evaluation of retinal function in Prph2Rd2/Rd2 mice following AAV-mediated gene replacement therapy.
The journal of gene medicine 2003;5(9):757-64.
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2003: Smith Alexander J; Schlichtenbrede Frank C; Tschernutter Marion; Bainbridge James W; Thrasher Adrian J; Ali Robin R
AAV-Mediated gene transfer slows photoreceptor loss in the RCS rat model of retinitis pigmentosa.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(2):188-95.
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2003: Bainbridge J W B; Mistry A; Schlichtenbrede F C; Smith A; Broderick C; De Alwis M; Georgiadis A; Taylor P M; Squires M; Sethi C; Charteris D; Thrasher A J; Sargan D; Ali R R
Stable rAAV-mediated transduction of rod and cone photoreceptors in the canine retina.
Gene therapy 2003;10(16):1336-44.
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2003: Howe Steven; Thrasher Adrian J
Gene therapy for inherited immunodeficiencies.
Current hematology reports 2003;2(4):328-34.
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2003: Bainbridge J W B; Mistry A; Binley K; De Alwis M; Thrasher A J; Naylor S; Ali R R
Hypoxia-regulated transgene expression in experimental retinal and choroidal neovascularization.
Gene therapy 2003;10(12):1049-54.
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2003: Bainbridge James W B; Mistry Ajay R; Thrasher Adrian J; Ali Robin R
Gene therapy for ocular angiogenesis.
Clinical science (London, England : 1979) 2003;104(6):561-75.
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2003: Siapati K E; Barker S; Kinnon C; Michalski A; Anderson R; Brickell P; Thrasher A J; Hart S L
Improved antitumour immunity in murine neuroblastoma using a combination of IL-2 and IL-12.
British journal of cancer 2003;88(10):1641-8.
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2003: Schlichtenbrede F C; MacNeil A; Bainbridge J W B; Tschernutter M; Thrasher A J; Smith A J; Ali R R
Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degeneration.
Gene therapy 2003;10(6):523-7.
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2002: Gaspar Hubert B; Sharifi Reza; Gilmour Kimberly C; Thrasher Adrian J
X-linked lymphoproliferative disease: clinical, diagnostic and molecular perspective.
British journal of haematology 2002;119(3):585-95.
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2002: Binley Katie; Askham Zoe; Iqball Sharifah; Spearman Hayley; Martin Leigh; de Alwis Mahesh; Thrasher Adrian J; Ali Robin R; Maxwell Patrick H; Kingsman Susan; Naylor Stuart
Long-term reversal of chronic anemia using a hypoxia-regulated erythropoietin gene therapy.
Blood 2002;100(7):2406-13.
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2002: Thrasher Adrian J
WASp in immune-system organization and function.
Nature reviews. Immunology 2002;2(9):635-46.
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2002: Jones Gareth E; Zicha Daniel; Dunn Graham A; Blundell Mike; Thrasher Adrian
Restoration of podosomes and chemotaxis in Wiskott-Aldrich syndrome macrophages following induced expression of WASp.
The international journal of biochemistry & cell biology 2002;34(7):806-15.
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2002: Qasim W; Thrasher A J; Buddle J; Kinnon C; Black M E; Gaspar H B
T cell transduction and suicide with an enhanced mutant thymidine kinase.
Gene therapy 2002;9(12):824-7.
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2002: Morgan Jennifer E; Gross Jacqueline G; Pagel Charles N; Beauchamp Jonathan R; Fassati Ariberto; Thrasher Adrian J; Di Santo James P; Fisher Ivan B; Shiwen Xu; Abraham David J; Partridge Terence A
Myogenic cell proliferation and generation of a reversible tumorigenic phenotype are triggered by preirradiation of the recipient site.
The Journal of cell biology 2002;157(4):693-702.
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2002: Demaison Christophe; Parsley Kathryn; Brouns Gaby; Scherr Michaela; Battmer Karin; Kinnon Christine; Grez Manuel; Thrasher Adrian J
High-level transduction and gene expression in hematopoietic repopulating cells using a human immunodeficiency [correction of imunodeficiency] virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter.
Human gene therapy 2002;13(7):803-13.
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2002: Langrish C L; Buddle J C; Thrasher A J; Goldblatt D
Neonatal dendritic cells are intrinsically biased against Th-1 immune responses.
Clinical and experimental immunology 2002;128(1):118-23.
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2002: Hacein-Bey-Abina Salima; Le Deist Françoise; Carlier Frédérique; Bouneaud Cécile; Hue Christophe; De Villartay Jean-Pierre; Thrasher Adrian J; Wulffraat Nicolas; Sorensen Ricardo; Dupuis-Girod Sophie; Fischer Alain; Davies E Graham; Kuis Wietse; Leiva Lilly; Cavazzana-Calvo Marina
Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy.
The New England journal of medicine 2002;346(16):1185-93.
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2002: Bainbridge J W B; Mistry A; De Alwis M; Paleolog E; Baker A; Thrasher A J; Ali R R
Inhibition of retinal neovascularisation by gene transfer of soluble VEGF receptor sFlt-1.
Gene therapy 2002;9(5):320-6.
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2002: Sarra G M; Stephens C; Schlichtenbrede F C; Bainbridge J W B; Thrasher A J; Luthert P J; Ali R R
Kinetics of transgene expression in mouse retina following sub-retinal injection of recombinant adeno-associated virus.
Vision research 2002;42(4):541-9.
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2002: Yong Kwee L; Fahey Anne; Pahal Gurmit; Linch David C; Pizzey Arnold; Thomas N Shaun B; Jauniaux Eric; Kinnon Christine; Thrasher Adrian J
Fetal haemopoietic cells display enhanced migration across endothelium.
British journal of haematology 2002;116(2):392-400.
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2002: Li Jian-Mei; Mullen Adrian M; Yun Sheng; Wientjes Frans; Brouns Gabi Y; Thrasher Adrian J; Shah Ajay M
Essential role of the NADPH oxidase subunit p47(phox) in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-alpha.
Circulation research 2002;90(2):143-50.
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2002: Mistry Ajay R; De Alwis Mahesh; Feudner Elisabeth; Ali Robin R; Thrasher Adrian J
High-titer stocks of adeno-associated virus from replicating amplicons and herpes vectors.
Methods in molecular medicine 2002;69():445-60.
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2001: Bainbridge J W; Stephens C; Parsley K; Demaison C; Halfyard A; Thrasher A J; Ali R R
In vivo gene transfer to the mouse eye using an HIV-based lentiviral vector; efficient long-term transduction of corneal endothelium and retinal pigment epithelium.
Gene therapy 2001;8(21):1665-8.
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2001: Sarra G M; Stephens C; de Alwis M; Bainbridge J W; Smith A J; Thrasher A J; Ali R R
Gene replacement therapy in the retinal degeneration slow (rds) mouse: the effect on retinal degeneration following partial transduction of the retina.
Human molecular genetics 2001;10(21):2353-61.
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2001: Nicklin S A; Buening H; Dishart K L; de Alwis M; Girod A; Hacker U; Thrasher A J; Ali R R; Hallek M; Baker A H
Efficient and selective AAV2-mediated gene transfer directed to human vascular endothelial cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;4(3):174-81.
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2001: Burns S; Thrasher A J; Blundell M P; Machesky L; Jones G E
Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation.
Blood 2001;98(4):1142-9.
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2001: Feudner E; de Alwis M; Thrasher A J; Ali R R; Fauser S
Optimization of recombinant adeno-associated virus production using an herpes simplex virus amplicon system.
Journal of virological methods 2001;96(2):97-105.
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2001: Qasim W; Gilmour K C; Heath S; Ashton E; Cranston T; Thomas A; Finn A; Davies E G; Thrasher A J; Kinnon C; Jones A; Gaspar H B
Protein assays for diagnosis of Wiskott-Aldrich syndrome and X-linked thrombocytopenia.
British journal of haematology 2001;113(4):861-5.
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2001: Wright M J; Wightman L M; Lilley C; de Alwis M; Hart S L; Miller A; Coffin R S; Thrasher A; Latchman D S; Marber M S
In vivo myocardial gene transfer: optimization, evaluation and direct comparison of gene transfer vectors.
Basic research in cardiology 2001;96(3):227-36.
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2001: Leverrier Y; Lorenzi R; Blundell M P; Brickell P; Kinnon C; Ridley A J; Thrasher A J
Cutting edge: the Wiskott-Aldrich syndrome protein is required for efficient phagocytosis of apoptotic cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(8):4831-4.
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2001: Marshall C J; Thrasher A J
The embryonic origins of human haematopoiesis.
British journal of haematology 2001;112(4):838-50.
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2001: Reichel M B; Bainbridge J; Baker D; Thrasher A J; Bhattacharya S S; Ali R R
An immune response after intraocular administration of an adenoviral vector containing a beta galactosidase reporter gene slows retinal degeneration in the rd mouse.
The British journal of ophthalmology 2001;85(3):341-4.
-
2000: Thrasher A J; Burns S; Lorenzi R; Jones G E
The Wiskott-Aldrich syndrome: disordered actin dynamics in haematopoietic cells.
Immunological reviews 2000;178():118-28.
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2000: Marshall C J; Kinnon C; Thrasher A J
Polarized expression of bone morphogenetic protein-4 in the human aorta-gonad-mesonephros region.
Blood 2000;96(4):1591-3.
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2000: Ali R R; Sarra G M; Stephens C; Alwis M D; Bainbridge J W; Munro P M; Fauser S; Reichel M B; Kinnon C; Hunt D M; Bhattacharya S S; Thrasher A J
Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy.
Nature genetics 2000;25(3):306-10.
-
2000: Gilmour K C; Cranston T; Jones A; Davies E G; Goldblatt D; Thrasher A; Kinnon C; Nichols K E; Gaspar H B
Diagnosis of X-linked lymphoproliferative disease by analysis of SLAM-associated protein expression.
European journal of immunology 2000;30(6):1691-7.
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2000: Lorenzi R; Brickell P M; Katz D R; Kinnon C; Thrasher A J
Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis.
Blood 2000;95(9):2943-6.
-
2000: Thrasher A J; Kinnon C
The Wiskott-Aldrich syndrome.
Clinical and experimental immunology 2000;120(1):2-9.
-
2000: White H; Thrasher A; Veys P; Kinnon C; Gaspar H B
Intrinsic defects of B cell function in X-linked severe combined immunodeficiency.
European journal of immunology 2000;30(3):732-7.
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2000: Demaison C; Brouns G; Blundell M P; Goldman J P; Levinsky R J; Grez M; Kinnon C; Thrasher A J
A defined window for efficient gene marking of severe combined immunodeficient-repopulating cells using a gibbon ape leukemia virus-pseudotyped retroviral vector.
Human gene therapy 2000;11(1):91-100.
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1999: Blundell M P; Demaison C; Brouns G; Goldman J P; Gaspar H B; Kinnon C; Thrasher A J; Lazzari L; Sirchia G
Quality of repopulation in nonobese diabetic severe combined immunodeficient mice engrafted with expanded cord blood CD34+ cells.
Blood 1999;94(9):3269-70.
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1999: Zhang X; De Alwis M; Hart S L; Fitzke F W; Inglis S C; Boursnell M E; Levinsky R J; Kinnon C; Ali R R; Thrasher A J
High-titer recombinant adeno-associated virus production from replicating amplicons and herpes vectors deleted for glycoprotein H.
Human gene therapy 1999;10(15):2527-37.
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1999: Thrasher A J; Burns S
Wiskott-Aldrich syndrome: a disorder of haematopoietic cytoskeletal regulation.
Microscopy research and technique 1999;47(2):107-13.
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1999: Davies E G; Thrasher A; Lacey K; Harper J
Topical cidofovir for severe molluscum contagiosum.
Lancet 1999;353(9169):2042.
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1999: Marshall C J; Moore R L; Thorogood P; Brickell P M; Kinnon C; Thrasher A J
Detailed characterization of the human aorta-gonad-mesonephros region reveals morphological polarity resembling a hematopoietic stromal layer.
Developmental dynamics : an official publication of the American Association of Anatomists 1999;215(2):139-47.
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1999: Goldblatt D; Butcher J; Thrasher A J; Russell-Eggitt I
Chorioretinal lesions in patients and carriers of chronic granulomatous disease.
The Journal of pediatrics 1999;134(6):780-3.
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1998: Thrasher A J; Jones G E; Kinnon C; Brickell P M; Katz D R
Is Wiskott--Aldrich syndrome a cell trafficking disorder?
Immunology today 1998;19(12):537-9.
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1998: Povey J; Weeratunge N; Marden C; Sehgal A; Thrasher A; Casimir C
Enhanced retroviral transduction of 5-fluorouracil-resistant human bone marrow (stem) cells using a genetically modified packaging cell line.
Blood 1998;92(11):4080-9.
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1998: Ali R R; Reichel M B; Byrnes A P; Stephens C J; Thrasher A J; Baker D; Hunt D M; Bhattacharya S S
Co-injection of adenovirus expressing CTLA4-Ig prolongs adenovirally mediated lacZ reporter gene expression in the mouse retina.
Gene therapy 1998;5(11):1561-5.
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1998: Goldman J P; Blundell M P; Lopes L; Kinnon C; Di Santo J P; Thrasher A J
Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor gamma chain.
British journal of haematology 1998;103(2):335-42.
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1998: Schilz A J; Brouns G; Knöss H; Ottmann O G; Hoelzer D; Fauser A A; Thrasher A J; Grez M
High efficiency gene transfer to human hematopoietic SCID-repopulating cells under serum-free conditions.
Blood 1998;92(9):3163-71.
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1998: Binks M; Jones G E; Brickell P M; Kinnon C; Katz D R; Thrasher A J
Intrinsic dendritic cell abnormalities in Wiskott-Aldrich syndrome.
European journal of immunology 1998;28(10):3259-67.
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1998: Reichel M B; Ali R R; Thrasher A J; Hunt D M; Bhattacharya S S; Baker D
Immune responses limit adenovirally mediated gene expression in the adult mouse eye.
Gene therapy 1998;5(8):1038-46.
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1998: Zicha D; Allen W E; Brickell P M; Kinnon C; Dunn G A; Jones G E; Thrasher A J
Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome.
British journal of haematology 1998;101(4):659-65.
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1998: Brickell P M; Katz D R; Thrasher A J
Wiskott-Aldrich syndrome: current research concepts.
British journal of haematology 1998;101(4):603-8.
-
1998: Coffin R S; Thomas S K; Thomas N S; Lilley C E; Pizzey A R; Griffiths C H; Gibb B J; Wagstaff M J; Inges S J; Binks M H; Chain B M; Thrasher A J; Rutault K; Latchman D S
Pure populations of transduced primary human cells can be produced using GFP expressing herpes virus vectors and flow cytometry.
Gene therapy 1998;5(5):718-22.
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1998: Hart S L; Arancibia-Cárcamo C V; Wolfert M A; Mailhos C; O'Reilly N J; Ali R R; Coutelle C; George A J; Harbottle R P; Knight A M; Larkin D F; Levinsky R J; Seymour L W; Thrasher A J; Kinnon C
Lipid-mediated enhancement of transfection by a nonviral integrin-targeting vector.
Human gene therapy 1998;9(4):575-85.
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1998: Ali R R; Reichel M B; De Alwis M; Kanuga N; Kinnon C; Levinsky R J; Hunt D M; Bhattacharya S S; Thrasher A J
Adeno-associated virus gene transfer to mouse retina.
Human gene therapy 1998;9(1):81-6.
-
1997: Thrasher A J; Goldman J; de Alwis M; Porter C D; Kinnon C
Gene therapy for primary immunodeficiency.
Biochemical Society transactions 1997;25(2):537-40.
-
1996: Ali R R; Reichel M B; Thrasher A J; Levinsky R J; Kinnon C; Kanuga N; Hunt D M; Bhattacharya S S
Gene transfer into the mouse retina mediated by an adeno-associated viral vector.
Human molecular genetics 1996;5(5):591-4.
-
1995: Thrasher A; Kinnon C
Gene therapy for primary immunodeficiency.
Gene therapy 1995;2(9):601-2.
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1995: Thrasher A J; de Alwis M; Casimir C M; Kinnon C; Page K; Lebkowski J; Segal A W; Levinsky R J
Generation of recombinant adeno-associated virus (rAAV) from an adenoviral vector and functional reconstitution of the NADPH-oxidase.
Gene therapy 1995;2(7):481-5.
-
1995: Thrasher A J; de Alwis M; Casimir C M; Kinnon C; Page K; Lebkowski J; Segal A W; Levinsky R J
Functional reconstitution of the NADPH-oxidase by adeno-associated virus gene transfer.
Blood 1995;86(2):761-5.
-
1995: Thrasher A J; Casimir C M; Kinnon C; Morgan G; Segal A W; Levinsky R J
Gene transfer to primary chronic granulomatous disease monocytes.
Lancet 1995;346(8967):92-3.
-
1995: Chetty M; Thrasher A J; Abo A; Casimir C M
Low NADPH oxidase activity in Epstein-Barr-virus-immortalized B-lymphocytes is due to a post-transcriptional block in expression of cytochrome b558.
The Biochemical journal 1995;306 ( Pt 1)():141-5.
-
1995: Levin M; Newport M J; D'Souza S; Kalabalikis P; Brown I N; Lenicker H M; Agius P V; Davies E G; Thrasher A; Klein N
Familial disseminated atypical mycobacterial infection in childhood: a human mycobacterial susceptibility gene?
Lancet 1995;345(8942):79-83.
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1994: Thrasher A J; Keep N H; Wientjes F; Segal A W
Chronic granulomatous disease.
Biochimica et biophysica acta 1994;1227(1-2):1-24.
-
1993: Thrasher A; Segal A; Casimir C
Chronic granulomatous disease: towards gene therapy.
Immunodeficiency 1993;4(1-4):327-33.
-
1992: Thrasher A; Chetty M; Casimir C; Segal A W
Restoration of superoxide generation to a chronic granulomatous disease-derived B-cell line by retrovirus mediated gene transfer.
Blood 1992;80(5):1125-9.
-
1992: Abo A; Boyhan A; West I; Thrasher A J; Segal A W
Reconstitution of neutrophil NADPH oxidase activity in the cell-free system by four components: p67-phox, p47-phox, p21rac1, and cytochrome b-245.
The Journal of biological chemistry 1992;267(24):16767-70.
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