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Ivan Borrello

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TOP 3
Ivan Borrello
Can we change the disease biology of multiple myeloma?
Atul Bedi; Rishi Bedi; Ivan Borrello; Joseph A Califano; Xiaofei Chang; Christine H Chung; Michael Considine; Elana J Fertig; Kimberly Noonan; Vui Pham; David Sidransky; Rajani Ravi
Inhibition of TGF-β enhances the in vivo antitumor efficacy of EGF receptor-targeted therapy.
Asher Chanan-Khan; Meletios Dimopoulos; Robin Foà; Andrzej Hellmann; Sagar Lonial; Arlene S Swern; Donna Weber; Ivan Borrello; Robert Knight
Lenalidomide in combination with dexamethasone improves survival and time-to-progression in patients ≥65 years old with relapsed or refractory multiple myeloma.

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All Publications

2012: Ivan Borrello
Can we change the disease biology of multiple myeloma?
Leukemia research 2012;36 Suppl 1():S3-12.
2012: Atul Bedi; Rishi Bedi; Ivan Borrello; Joseph A Califano; Xiaofei Chang; Christine H Chung; Michael Considine; Elana J Fertig; Kimberly Noonan; Vui Pham; David Sidransky; Rajani Ravi
Inhibition of TGF-β enhances the in vivo antitumor efficacy of EGF receptor-targeted therapy.
Molecular cancer therapeutics 2012;11(11):2429-39.
2012: Asher Chanan-Khan; Meletios Dimopoulos; Robin Foà; Andrzej Hellmann; Sagar Lonial; Arlene S Swern; Donna Weber; Ivan Borrello; Robert Knight
Lenalidomide in combination with dexamethasone improves survival and time-to-progression in patients ≥65 years old with relapsed or refractory multiple myeloma.
International journal of hematology 2012;96(2):254-62.
2012: Kimberly Noonan; Marcela F Pasetti; Lakshmi Rudraraju; Amy Emerling; Anna Ferguson; Carol Ann Huff; Ivan Borrello
Lenalidomide-induced immunomodulation in multiple myeloma: impact on vaccines and antitumor responses.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(5):1426-34.
2012: William Matsui; Ivan Borrello; Constantine Mitsiades
Autologous stem cell transplantation and multiple myeloma cancer stem cells.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2012;18(1 Suppl):S27-32.
2011: Kimberly Noonan; Ivan Borrello
The immune microenvironment of myeloma.
Cancer microenvironment : official journal of the International Cancer Microenvironment Society 2011;4(3):313-23.
2011: Asher Chanan-Khan; Kasyapa Chitta; Myron S Czuczman; Noreen Ersing; Kelvin Lee; Terry L Mashtare; Aisha Masood; Aneel Paulus; Taimur Sher; Abhisek Swaika; Paul K Wallace; Greg Wilding; Ivan Borrello; Naveen Bangia
Biological effects and clinical significance of lenalidomide-induced tumour flare reaction in patients with chronic lymphocytic leukaemia: in vivo evidence of immune activation and antitumour response.
British journal of haematology 2011;155(4):457-67.
2011: Douglas E Gladstone; Carol Ann Huff; Richard J Jones; Yvette L Kasamon; Hyam I Levitsky; Leo Luznik; William Matsui; Jonathan D Powell; Richard F Ambinder; F. JAVIER BOLANOS MEADE; Ivan Borrello; Robert A Brodsky; Ian W Flinn; Ephraim J Fuchs; Marianna Zahurak; Lode J Swinnen
High-dose cyclophosphamide and rituximab without stem cell transplant: a feasibility study for low grade B-cell, transformed and mantle cell lymphomas.
Leukemia & lymphoma 2011;52(11):2076-81.
2011: Christiane Meyer; Wolfram Osen; Marcel Ramacher; Dirk Schadendorf; Alexandra Sevko; Michal Baniyash; Alexandr V Bazhin; Ivan Borrello; Christine S Falk; Masashi Kato; Viktor Umansky
Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(41):17111-6.
2011: Claudio Tripodo; Sonam Prakash; Sabina Sangaletti; Ivan Borrello; Mario P Colombo; Giovanni Franco; Attilio Orazi; Pier P Piccaluga; Stefano A Pileri
The bone marrow stroma in hematological neoplasms--a guilty bystander.
Nature reviews. Clinical oncology 2011;8(8):456-66.
2011: Nilanjan Ghosh; Xiaobu Ye; Anna Ferguson; Carol Ann Huff; Ivan Borrello
Bortezomib and thalidomide, a steroid free regimen in newly diagnosed patients with multiple myeloma.
British journal of haematology 2011;152(5):593-9.
2010: Kimberly Noonan; LUIGI MARCHIONNI; Judy Anderson; Drew M Pardoll; G David Roodman; Ivan Borrello
A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma.
Blood 2010;116(18):3554-63.
2010: Asher A Chanan-Khan; Ivan Borrello; Kelvin P Lee; Donna E Reece
Development of target-specific treatments in multiple myeloma.
British journal of haematology 2010;151(1):3-15.
2010: Leo Luznik; Javier Bolaños-Meade; Marianna Zahurak; Allen R Chen; B Douglas Smith; Robert A Brodsky; Carol Ann Huff; Ivan Borrello; William Matsui; Jonathan D Powell; Yvette L Kasamon; Steven Goodman; Allan Hess; Hyam I Levitsky; Richard F Ambinder; Richard J Jones; Ephraim J Fuchs
High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease.
Blood 2010;115(16):3224-30.
2010: Yvette L Kasamon; Leo Luznik; Mary S Leffell; Jeanne Kowalski; Hua-Ling Tsai; F. JAVIER BOLANOS MEADE; Lawrence E Morris; Pamela Crilley; Paul V O'Donnell; Nancy Rossiter; Carol Ann Huff; Robert A Brodsky; William Matsui; Lode J Swinnen; Ivan Borrello; Jonathan D Powell; Richard F Ambinder; Richard J Jones; Ephraim J Fuchs
Nonmyeloablative HLA-haploidentical bone marrow transplantation with high-dose posttransplantation cyclophosphamide: effect of HLA disparity on outcome.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2010;16(4):482-9.
2010: Rafael Fonseca; Paul G Richardson; Sergio Giralt; Sagar Lonial; S Vincent Rajkumar; A Keith Stewart; William Bensinger; George Somlo; Robert Vescio; Joseph Mikhael; Craig Reeder; Rodger Tiedemann; Guido Tricot; Robert Rifkin; John Shaughnessy; Nikhil Munshi; Noopur Raje; Irene Ghobrial; Jacob Laubach; Robert Schlossman; Steven Treon; Anuj Mahindra; David Avigan; Jacalyn Rosenblatt; Sundar Jagannath; Ruben Niesvizky; Heather Landau; Selina Chen-Kiang; David S Siegel; Todd Zimmerman; Jayesh Mehta; David Vesole; Steven Rosen; Craig Hofmeister; Martha Lacy; Angela Dispenzieri; Ivan Borrello; Suzanne R Hayman; Shaji Kumar; Frances Buadi; David Dingli; Stephen Russell; Melissa Alsina Melissa Alsina; Hugo Fernandez; Vivek Roy; Denise Pereira; Edward Stadtmauer; Ravi Vij; Andrzej Jakubowiak; Suzanne Lentzsch; Kevin Song; Suzanne Trudel; Christine Chen; Donna Reece; Douglas Stewart; Seema Singhal; Raymond Comenzo; Morie A Gertz; Philip R Greipp; Brian Durie; Bart Barlogie; Kenneth C Anderson; William Dalton; Morton Coleman; Susie Novis; Robert A Kyle
Conflicts of interest, authorship, and disclosures in industry-related scientific publications.
Mayo Clinic proceedings. Mayo Clinic 2010;85(2):197-9; author reply 201-4.
2009: Ivan Borrello; Hyam I Levitsky; Wendy Stock; Dorie Sher; LU QIN; Daniel J DeAngelo; Edwin P Alyea; Richard M Stone; Lloyd E Damon; Charles A Linker; Daniel J Maslyar; Kristen M Hege
Granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting cellular immunotherapy in combination with autologous stem cell transplantation (ASCT) as postremission therapy for acute myeloid leukemia (AML).
Blood 2009;114(9):1736-45.
2009: Ivan Borrello
Lenalidomide in renal insufficiency--balancing the risks and benefits.
British journal of haematology 2009;144(3):446-7; author reply 447-8.
2008: Vinay Chaudhry; David R Cornblath; Michael Polydefkis; Anna Ferguson; Ivan Borrello
Characteristics of bortezomib- and thalidomide-induced peripheral neuropathy.
Journal of the peripheral nervous system : JPNS 2008;13(4):275-82.
2008: Erica D Warlick; Paul V O'Donnell; Michael J Borowitz; Nichon Grupka; Lauren Decloe; Elizabeth Garrett-Mayer; Ivan Borrello; Robert A Brodsky; Ephraim J Fuchs; Carol Ann Huff; Leo Luznik; William Matsui; Richard F Ambinder; Richard J Jones; B Douglas Smith
Myeloablative allogeneic bone marrow transplant using T cell depleted allografts followed by post-transplant GM-CSF in high-risk myelodysplastic syndromes.
Leukemia research 2008;32(9):1439-47.
2008: paolo serafini; Stephanie Mgebroff; Kimberly Noonan; Ivan Borrello
Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells.
Cancer research 2008;68(13):5439-49.
2008: Leo Luznik; Paul V O'Donnell; HEATHER SYMONS; Allen R Chen; Mary S Leffell; Marianna Zahurak; Ted A Gooley; Steven Piantadosi; Michele Kaup; Richard F Ambinder; Carol Ann Huff; William Matsui; F. JAVIER BOLANOS MEADE; Ivan Borrello; Jonathan D Powell; Elizabeth Harrington; Sandy Warnock; Mary Flowers; Robert A Brodsky; Brenda M Sandmaier; Rainer F Storb; Richard J Jones; Ephraim J Fuchs
HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2008;14(6):641-50.
2008: Paria Mirmonsef; Gladys Tan; Gang Zhou; Tricia Morino; Kimberly Noonan; Ivan Borrello; Hyam I Levitsky
Escape from suppression: tumor-specific effector cells outcompete regulatory T cells following stem-cell transplantation.
Blood 2008;111(4):2112-21.
2008: William Matsui; Qiuju Wang; James P Barber; Sarah Brennan; B Douglas Smith; Ivan Borrello; Ian K McNiece; Lan Lin; Richard F Ambinder; CRAIG PEACOCK; DAVID WATKINS; Carol Ann Huff; Richard J Jones
Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance.
Cancer research 2008;68(1):190-7.
2007: Donna M Weber; Christine Chen; Ruben Niesvizky; Michael Wang; Andrew Belch; Edward A Stadtmauer; David Siegel; Ivan Borrello; S Vincent Rajkumar; Asher Chanan-Khan; Sagar Lonial; Zhinuan Yu; John Patin; Marta Olesnyckyj; Jerome B Zeldis; Robert D Knight
Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America.
The New England journal of medicine 2007;357(21):2133-42.
2007: F. JAVIER BOLANOS MEADE; Elizabeth Garrett-Mayer; Leo Luznik; Viki Anders; Jennifer Webb; Ephraim J Fuchs; Carol Ann Huff; William Matsui; Ivan Borrello; Robert A Brodsky; Yvette L Kasamon; Lode J Swinnen; Ian W Flinn; Richard F Ambinder; Richard J Jones; Allan Hess; Georgia B Vogelsang
Induction of autologous graft-versus-host disease: results of a randomized prospective clinical trial in patients with poor risk lymphoma.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2007;13(10):1185-91.
2006: paolo serafini; Kristen Meckel; Michael Kelso; Kimberly Noonan; Joseph A Califano; Wayne M Koch; Luigi Dolcetti; Vincenzo Bronte; Ivan Borrello
Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function.
The Journal of experimental medicine 2006;203(12):2691-702.
2006: Giovanna Gallina; Luigi Dolcetti; paolo serafini; Carmela De Santo; Ilaria Marigo; Mario P Colombo; Giuseppe Basso; Frank Brombacher; Ivan Borrello; Paola Zanovello; Silvio Bicciato; Vincenzo Bronte
Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells.
The Journal of clinical investigation 2006;116(10):2777-90.
2006: Carol Ann Huff; Ephraim J Fuchs; B Douglas Smith; Amanda Blackford; Elizabeth Garrett-Mayer; Robert A Brodsky; Ian W Flinn; Richard F Ambinder; Ivan Borrello; William Matsui; Georgia B Vogelsang; Constance A Griffin; Leo Luznik; Richard J Jones
Graft-versus-host reactions and the effectiveness of donor lymphocyte infusions.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2006;12(4):414-21.
2006: Pedro Horna; Alex Cuenca; Fengdong Cheng; Jason Brayer; Hong-Wei Wang; Ivan Borrello; Hyam I Levitsky; Eduardo M Sotomayor
In vivo disruption of tolerogenic cross-presentation mechanisms uncovers an effective T-cell activation by B-cell lymphomas leading to antitumor immunity.
Blood 2006;107(7):2871-8.
2006: paolo serafini; Ivan Borrello; Vincenzo Bronte
Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression.
Seminars in cancer biology 2006;16(1):53-65.
2005: Kimberly Noonan; William Matsui; paolo serafini; Rebecca Carbley; Gladys Tan; Jahan Khalili; Mark Bonyhadi; Hyam I Levitsky; Katharine A Whartenby; Ivan Borrello
Activated marrow-infiltrating lymphocytes effectively target plasma cells and their clonogenic precursors.
Cancer research 2005;65(5):2026-34.
2004: paolo serafini; Rebecca Carbley; Kimberly Noonan; Gladys Tan; Vincenzo Bronte; Ivan Borrello
High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cells.
Cancer research 2004;64(17):6337-43.
2004: Michael A Caligiuri; Andrea Velardi; David A Scheinberg; Ivan Borrello
Immunotherapeutic approaches for hematologic malignancies.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2004;():337-53.
2003: Alex Cuenca; Fengdong Cheng; Hongwei Wang; Jason Brayer; Pedro Horna; Lingping Gu; Harold Bien; Ivan Borrello; Hyam I Levitsky; Eduardo M Sotomayor
Extra-lymphatic solid tumor growth is not immunologically ignored and results in early induction of antigen-specific T-cell anergy: dominant role of cross-tolerance to tumor antigens.
Cancer research 2003;63(24):9007-15.
2003: Yan Cui; Erin Kelleher; Erin Straley; Ephraim J Fuchs; Kevin Gorski; Hyam I Levitsky; Ivan Borrello; Curt I Civin; Stephen P Schoenberger; Linzhao Cheng; Drew M Pardoll; Katharine A Whartenby
Immunotherapy of established tumors using bone marrow transplantation with antigen gene--modified hematopoietic stem cells.
Nature medicine 2003;9(7):952-8.
2003: Carol Ann Huff; Ephraim J Fuchs; Stephen J Noga; Paul V O'Donnell; Richard F Ambinder; Louis F Diehl; Ivan Borrello; Georgia B Vogelsang; Carole B Miller; Ian W Flinn; Robert A Brodsky; Deborah Marcellus; Richard J Jones
Long-term follow-up of T cell-depleted allogeneic bone marrow transplantation in refractory multiple myeloma: importance of allogeneic T cells.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2003;9(5):312-9.
2003: Leo Luznik; Jill E Slansky; Sanju Jalla; Ivan Borrello; Hyam I Levitsky; Drew M Pardoll; Ephraim J Fuchs
Successful therapy of metastatic cancer using tumor vaccines in mixed allogeneic bone marrow chimeras.
Blood 2003;101(4):1645-52.
2002: Ivan Borrello; Drew M Pardoll
GM-CSF-based cellular vaccines: a review of the clinical experience.
Cytokine & growth factor reviews 2002;13(2):185-93.
2002: Ivan Borrello; Eduardo M Sotomayor
Cancer vaccines for hematologic malignancies.
Cancer control : journal of the Moffitt Cancer Center 2002;9(2):138-51.
2001: Eduardo M Sotomayor; Ivan Borrello; FM Rattis; Alex Cuenca; J Abrams; K Staveley-O'Carroll; Hyam I Levitsky
Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression.
Blood 2001;98(4):1070-7.
2000: J Margolis; Ivan Borrello; Ian W Flinn
New approaches to treating malignances with stem cell transplantation.
Seminars in oncology 2000;27(5):524-30.
2000: Ivan Borrello; Eduardo M Sotomayor; FM Rattis; S K Cooke; L Gu; Hyam I Levitsky
Sustaining the graft-versus-tumor effect through posttransplant immunization with granulocyte-macrophage colony-stimulating factor (GM-CSF)-producing tumor vaccines.
Blood 2000;95(10):3011-9.
1999: Eduardo M Sotomayor; Ivan Borrello; E Tubb; J P Allison; Hyam I Levitsky
In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11476-81.
1999: Ivan Borrello; Eduardo M Sotomayor; S Cooke; Hyam I Levitsky
A universal granulocyte-macrophage colony-stimulating factor-producing bystander cell line for use in the formulation of autologous tumor cell-based vaccines.
Human gene therapy 1999;10(12):1983-91.
1999: Eduardo M Sotomayor; Ivan Borrello; E Tubb; FM Rattis; H Bien; Z Lu; S Fein; Stephen P Schoenberger; Hyam I Levitsky
Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40.
Nature medicine 1999;5(7):780-7.
1998: K Staveley-O'Carroll; Eduardo M Sotomayor; J Montgomery; Ivan Borrello; L Hwang; S Fein; Drew M Pardoll; Hyam I Levitsky
Induction of antigen-specific T cell anergy: An early event in the course of tumor progression.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(3):1178-83.
1996: Eduardo M Sotomayor; Ivan Borrello; Hyam I Levitsky
Tolerance and cancer: a critical issue in tumor immunology.
Critical reviews in oncogenesis 1996;7(5-6):433-56.
1989: C R King; Ivan Borrello; L Porter; P Comoglio; J Schlessinger
Ligand-independent tyrosine phosphorylation of EGF receptor and the erbB-2/neu proto-oncogene product is induced by hyperosmotic shock.
Oncogene 1989;4(1):13-8.
1988: C R King; Ivan Borrello; F Bellot; P Comoglio; J Schlessinger
Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3.
The EMBO journal 1988;7(6):1647-51.
1988: C Cochet; O Kashles; E M Chambaz; Ivan Borrello; C R King; J Schlessinger
Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical covalent cross-linking agent.
The Journal of biological chemistry 1988;263(7):3290-5.
1988: Pier Paolo Di Fiore; J Falco; Ivan Borrello; Bernard E Weissman; Stuart A Aaronson
The calcium signal for BALB/MK keratinocyte terminal differentiation counteracts epidermal growth factor (EGF) very early in the EGF-induced proliferative pathway.
Molecular and cellular biology 1988;8(2):557-63.