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Thomas Thum

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TOP 3
Virginija Jazbutyte; Annette Just; Susanne Kneitz; Johann Bauersachs; Jan Fiedler; Paolo Galuppo; Angelika Holzmann; Thomas Thum
MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart.
Johan M Lorenzen; Thomas Thum
MicroRNAs in idiopathic childhood nephrotic syndrome.
Jan Fiedler; Thomas Thum
MicroRNAs in myocardial infarction.

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2013: Virginija Jazbutyte; Annette Just; Susanne Kneitz; Johann Bauersachs; Jan Fiedler; Paolo Galuppo; Angelika Holzmann; Thomas Thum
MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart.
Age (Dordrecht, Netherlands) 2013;35(3):747-62.
2013: Johan M Lorenzen; Thomas Thum
MicroRNAs in idiopathic childhood nephrotic syndrome.
Clinical chemistry 2013;59(4):595-7.
2013: Jan Fiedler; Thomas Thum
MicroRNAs in myocardial infarction.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(2):201-5.
2013: Johan M Lorenzen; Christoph Wanner; Frank Weidemann; Esther Asan; Johann Bauersachs; Massimiliano Caprio; Bernd Dietrich; Georg Ertl; Jan Fiedler; Felix Fleissner; Virginija Jazbutyte; Nicola Karpinski; Thomas Thum
Pathologic endothelial response and impaired function of circulating angiogenic cells in patients with Fabry disease.
Basic research in cardiology 2013;108(1):311.
2012: S Dangwal; D Hartmann; Thomas Thum
MicroRNAs deciding cardiac stem cell fate.
Journal of molecular and cellular cardiology 2012;53(6):747-8.
2012: Claudia Bang; Thomas Thum
Exosomes: new players in cell-cell communication.
The international journal of biochemistry & cell biology 2012;44(11):2060-4.
2012: Seema Dangwal; Thomas Thum
MicroRNAs in platelet biogenesis and function.
Thrombosis and haemostasis 2012;108(4):599-604.
2012: Claudia Bang; Thomas Thum
Novel non-coding RNA-based therapeutic approaches to prevent statin-induced liver damage.
EMBO molecular medicine 2012;4(9):863-5.
2012: Johan M Lorenzen; Thomas Thum
Circulating and urinary microRNAs in kidney disease.
Clinical journal of the American Society of Nephrology : CJASN 2012;7(9):1528-33.
2012: Thomas Thum; Johan M Lorenzen
Cardiac fibrosis revisited by microRNA therapeutics.
Circulation 2012;126(7):800-2.
2012: Nils Pfaff; Thomas Thum; Thomas Moritz; Tobias Cantz
miRNAs involved in the generation, maintenance, and differentiation of pluripotent cells.
Journal of molecular medicine (Berlin, Germany) 2012;90(7):747-52.
2012: Johan Lorenzen; Seema Dangwal; Regalla Kumarswamy; Thomas Thum
MicroRNAs in diabetes and diabetes-associated complications.
RNA biology 2012;9(6):820-7.
2012: Christian Wolf; Dimitrios Tsikas; Frank Weidemann; Stefan D Anker; Johann Bauersachs; Georg Ertl; Johan M Lorenzen; Sylvia Stein; Stefan Störk OR Stoerk; Thomas Thum
Urinary asymmetric dimethylarginine (ADMA) is a predictor of mortality risk in patients with coronary artery disease.
International journal of cardiology 2012;156(3):289-94.
2012: Regalla Kumarswamy; Alexander R Lyon; Kenneth T MacLeod; Adam M Mills; Aanchal Pahuja; Julia Bretthauer; Cornelia Geers-Knörr; Roger J Hajjar; Sian E Harding; Theresia Kraft; Ingo Volkmann; Thomas Thum
SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway.
European heart journal 2012;33(9):1067-75.
2012: Claudia Bang; Jan Fiedler; Thomas Thum
Cardiovascular importance of the microRNA-23/27/24 family.
Microcirculation (New York, N.Y. : 1994) 2012;19(3):208-14.
2012: Thomas Thum; Manuel Mayr
Review focus on the role of microRNA in cardiovascular biology and disease.
Cardiovascular research 2012;93(4):543-4.
2012: S Dangwal; C Bang; Thomas Thum
Novel techniques and targets in cardiovascular microRNA research.
Cardiovascular research 2012;93(4):545-54.
2012: Regalla Kumarswamy; Da-Hee Park; Seema Dangwal; Virginija Jazbutyte; Ingo Volkmann; Thomas Thum
Transforming growth factor-β-induced endothelial-to-mesenchymal transition is partly mediated by microRNA-21.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(2):361-9.
2012: Johan M Lorenzen; Filippo Martino; Jan Menne; Senguel Samiri; Mario Schiffer; Bernhard M W Schmidt; Mascha Schmidt; Robert Dietrich; Hermann Haller; Meike Heeren; Jan T Kielstein; Karin Weissenborn; Hans Worthmann; Thomas Thum
Circulating microRNAs in patients with Shiga-Toxin-producing E. coli O104:H4 induced hemolytic uremic syndrome.
PloS one 2012;7(10):e47215.
2012: Virginija Jazbutyte; Johan M Lorenzen; Andreas Redel; Norbert Roewer; Jan Stumpner; Thomas Thum; Franz Kehl
Aromatase inhibition attenuates desflurane-induced preconditioning against acute myocardial infarction in male mouse heart in vivo.
PloS one 2012;7(8):e42032.
2012: Filippo Martino; Julius Schmidt; Mascha Schmidt; Michael Broll; Yvonne Görzig; Jan T Kielstein; Johan Lorenzen; Thomas Thum
Circulating microRNAs are not eliminated by hemodialysis.
PloS one 2012;7(6):e38269.
2011: Nils Pfaff; Axel Schambach; Tobias Cantz; Jan Fiedler; Angelika Holzmann; Thomas Moritz; Thomas Thum
miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2.
EMBO reports 2011;12(11):1153-9.
2011: J Fiedler; S K Gupta; Thomas Thum
Identification of cardiovascular microRNA targetomes.
Journal of molecular and cellular cardiology 2011;51(5):674-81.
2011: Christian Widera; Kai C Wollert; Claudia Bang; Johann Bauersachs; Kerstin Bethmann; Shashi K Gupta; Tibor Kempf; Johan M Lorenzen; Thomas Thum
Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome.
Journal of molecular and cellular cardiology 2011;51(5):872-5.
2011: Dorothee Hartmann; Thomas Thum
MicroRNAs and vascular (dys)function.
Vascular pharmacology 2011;55(4):92-105.
2011: Regalla Kumarswamy; Ingo Volkmann; Thomas Thum
Regulation and function of miRNA-21 in health and disease.
RNA biology 2011;8(5):706-13.
2011: Thomas Thum; Volker Wiebking; Georg Ertl; Johann Bauersachs
Organic nitrates differentially modulate circulating endothelial progenitor cells and endothelial function in patients with symptomatic coronary artery disease.
Antioxidants & redox signaling 2011;15(4):925-31.
2011: Felix Fleissner; Thomas Thum
Critical role of the nitric oxide/reactive oxygen species balance in endothelial progenitor dysfunction.
Antioxidants & redox signaling 2011;15(4):933-48.
2011: Jan Fiedler; Paolo Galuppo; Shashi K Gupta; Dorothee Hartmann; Jörg Heineke; Virginija Jazbutyte; Bettina C Kirchmaier; Susanne Kneitz; Johan Lorenzen; Xavier Loyer; Ulrich Martin; John T G Pena; Stefan Schulte-Merker; Cherin Sohn-Lee; juergen soutschek; Johann Bauersachs; Thomas Brand; Stefan Engelhardt; Georg Ertl; Thomas Tuschl; Thomas Thum
MicroRNA-24 regulates vascularity after myocardial infarction.
Circulation 2011;124(6):720-30.
2011: Johann Bauersachs; Thomas Thum
Biogenesis and regulation of cardiovascular microRNAs.
Circulation research 2011;109(3):334-47.
2011: Johan M Lorenzen; Robert Faulhaber-Walter; Danilo Fliser; Shashi K Gupta; Carsten Hafer; Hermann Haller; Jan T Kielstein; Philipp Kümpers; Thomas Thum
Circulating miR-210 predicts survival in critically ill patients with acute kidney injury.
Clinical journal of the American Society of Nephrology : CJASN 2011;6(7):1540-6.
2011: Johan M Lorenzen; Hermann Haller; Thomas Thum
MicroRNAs as mediators and therapeutic targets in chronic kidney disease.
Nature reviews. Nephrology 2011;7(5):286-94.
2011: Arash Haghikia; Ewa Missol-Kolka; Dimitrios Tsikas; Letizia Venturini; Stephanie Brundiers; Mirko Castoldi; Martina U Muckenthaler; Matthias Eder; Britta Stapel; Thomas Thum; Aiden Haghikia; Elisabeth Petrasch-Parwez; Helmut Drexler; Denise Hilfiker-Kleiner; Michaela Scherr
Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes.
European heart journal 2011;32(10):1287-97.
2011: Thomas Thum; Kerstin Schmitter; Felix Fleissner; Volker Wiebking; Bernd Dietrich; Julian D Widder; Virginija Jazbutyte; Stefanie Hahner; Georg Ertl; Johann Bauersachs
Impairment of endothelial progenitor cell function and vascularization capacity by aldosterone in mice and humans.
European heart journal 2011;32(10):1275-86.
2011: Christoph Kleinschnitz; Kinga Blecharz; Timo Kahles; Tobias Schwarz; Peter Kraft; Kerstin Göbel; Sven G Meuth; Malgorzata Burek; Thomas Thum; Guido Stoll; Carola Förster
Glucocorticoid insensitivity at the hypoxic blood-brain barrier can be reversed by inhibition of the proteasome.
Stroke; a journal of cerebral circulation 2011;42(4):1081-9.
2010: Shashi K Gupta; Claudia Bang; Thomas Thum
Circulating microRNAs as biomarkers and potential paracrine mediators of cardiovascular disease.
Circulation. Cardiovascular genetics 2010;3(5):484-8.
2010: Thomas Thum; Sandor Batkai; Philipp G Malinski; Thomas Becker; Iris Mevius; Jürgen Klempnauer; Hartmut H Meyer; Jürgen C Frölich; Jürgen Borlak; Dimitrios Tsikas
Measurement and diagnostic use of hepatic cytochrome P450 metabolism of oleic acid in liver disease.
Liver international : official journal of the International Association for the Study of the Liver 2010;30(8):1181-8.
2010: Thomas Thum
MicroRNAs: from basic regulation towards therapeutic approaches--passion, caution and patience required.
Current drug targets 2010;11(8):898-9.
2010: Virginija Jazbutyte; Thomas Thum
MicroRNA-21: from cancer to cardiovascular disease.
Current drug targets 2010;11(8):926-35.
2010: Felix Fleissner; Virginija Jazbutyte; Jan Fiedler; Shashi K Gupta; Xiaoke Yin; Qingbo Xu; Paolo Galuppo; Susanne Kneitz; Manuel Mayr; Georg Ertl; Johann Bauersachs; Thomas Thum
Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism.
Circulation research 2010;107(1):138-43.
2008: Thomas Thum; Daniele Catalucci; Johann Bauersachs
MicroRNAs: novel regulators in cardiac development and disease.
Cardiovascular research 2008;79(4):562-70.
2008: Daniela Fraccarollo; Julian Widder; Paolo Galuppo; Thomas Thum; Dimitrios Tsikas; Michael Hoffmann; Hartmut Ruetten; Georg Ertl; Johann Bauersachs
Improvement in left ventricular remodeling by the endothelial nitric oxide synthase enhancer AVE9488 after experimental myocardial infarction.
Circulation 2008;118(8):818-27.
2008: Marten Jakob; Thomas Thum
Recent patents on cardiovascular stem cells.
Recent patents on cardiovascular drug discovery 2008;3(1):59-72.
2007: Thomas Thum; Felix Fleissner; Ivonne Klink; Dimitrios Tsikas; Marten Jakob; Johann Bauersachs; Dirk O Stichtenoth
Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I.
The Journal of clinical endocrinology and metabolism 2007;92(11):4172-9.
2007: Kristine Chobanyan; Thomas Thum; Maria-Theresia Suchy; Bijun Zhu; Anja Mitschke; Frank-Mathias Gutzki; Bibiana Beckmann; Dirk O Stichtenoth; Dimitrios Tsikas
GC-MS assay for hepatic DDAH activity in diabetic and non-diabetic rats by measuring dimethylamine (DMA) formed from asymmetric dimethylarginine (ADMA): evaluation of the importance of S-nitrosothiols as inhibitors of DDAH activity in vitro and in vivo in humans.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;858(1-2):32-41.
2007: Jan T Kielstein; Karsten Sydow; Thomas Thum
Tilarginine in patients with acute myocardial infarction and cardiogenic shock.
JAMA : the journal of the American Medical Association 2007;298(9):971; author reply 972-3.
2007: Stefan Frantz; Jochen Tillmanns; Peter J Kuhlencordt; Isabel Schmidt; Anna Adamek; Charlotte Dienesch; Thomas Thum; Steve Gerondakis; Georg Ertl; Johann Bauersachs
Tissue-specific effects of the nuclear factor kappaB subunit p50 on myocardial ischemia-reperfusion injury.
The American journal of pathology 2007;171(2):507-12.
2007: Thomas Thum; Paolo Galuppo; Christian Wolf; Jan Fiedler; Susanne Kneitz; Linda W van Laake; Pieter A Doevendans; Christine L Mummery; Jürgen Borlak; Axel Haverich; Carina Gross; Stefan Engelhardt; Georg Ertl; Johann Bauersachs
MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure.
Circulation 2007;116(3):258-67.
2007: Dimitrios Tsikas; Thomas Thum; Thomas Becker; Vu Vi Pham; Kristine Chobanyan; Anja Mitschke; Bibiana Beckmann; Frank-Mathias Gutzki; Johann Bauersachs; Dirk O Stichtenoth
Accurate quantification of dimethylamine (DMA) in human urine by gas chromatography-mass spectrometry as pentafluorobenzamide derivative: evaluation of the relationship between DMA and its precursor asymmetric dimethylarginine (ADMA) in health and disease.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;851(1-2):229-39.
2007: Thomas Thum; Daniela Fraccarollo; Sabrina Thum; Maximilian Schultheiss; Andreas Daiber; Philip Wenzel; Thomas Munzel; Georg Ertl; Johann Bauersachs
Differential effects of organic nitrates on endothelial progenitor cells are determined by oxidative stress.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(4):748-54.
2007: Thomas Thum; Daniela Fraccarollo; Maximilian Schultheiss; Sabrina Froese; Paolo Galuppo; Julian Widder; Dimitrios Tsikas; Georg Ertl; Johann Bauersachs
Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes.
Diabetes 2007;56(3):666-74.
2007: Thomas Thum; Sarah Hoeber; Sabrina Froese; Ivonne Klink; Dirk O Stichtenoth; Paolo Galuppo; Marten Jakob; Dimitrios Tsikas; Stefan D Anker; Philip A Poole-Wilson; Jürgen Borlak; Georg Ertl; Johann Bauersachs
Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1.
Circulation research 2007;100(3):434-43.
2006: Thomas Thum; Daniela Fraccarollo; Paolo Galuppo; Dimitrios Tsikas; Stefan Frantz; Georg Ertl; Johann Bauersachs
Bone marrow molecular alterations after myocardial infarction: Impact on endothelial progenitor cells.
Cardiovascular research 2006;70(1):50-60.
2005: Thomas Thum; Dimitrios Tsikas; Sylvia Stein; Maximilian Schultheiss; Martin Eigenthaler; Stefan D Anker; Philip A Poole-Wilson; Georg Ertl; Johann Bauersachs
Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine.
Journal of the American College of Cardiology 2005;46(9):1693-701.
2005: Thomas Thum; Johann Bauersachs
Spotlight on endothelial progenitor cell inhibitors: short review.
Vascular medicine (London, England) 2005;10 Suppl 1():S59-64.
2005: Ralf Gerhard; Helma Tatge; Harald Genth; Thomas Thum; Jürgen Borlak; Gerhard Fritz; Ingo Just
Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB.
The Journal of biological chemistry 2005;280(2):1499-505.
2004: Fortunato Scalera; Jürgen Borlak; Bibiana Beckmann; Jens Martens-Lobenhoffer; Thomas Thum; Michael Täger; Stefanie M Bode-Böger
Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L-arginine accelerates endothelial cell senescence.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(10):1816-22.
2000: Rainer H Böger; Karsten Sydow; Jürgen Borlak; Thomas Thum; Henrike Lenzen; B Schubert; Dimitrios Tsikas; Stefanie M Bode-Böger
LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases.
Circulation research 2000;87(2):99-105.