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Kenneth Thummel

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Zhican Wang; Connie L Davis; Leslie J Dickmann; David L Eaton; Johanna W Lampe; Yvonne S Lin; Emma-Jane Poulton; Danny D Shen; Margaret C Shuhart; Kenneth E Thummel
Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D3 through CYP3A4 induction in vitro and in vivo: Implications for drug-induced osteomalacia.
Mary F Hebert; Menachem Miodovnik; Danny D Shen; Kenneth E Thummel; Jason G Umans; Songmao Zheng; Connie L Davis; Karen Hays; Thomas R Easterling
Interpreting tacrolimus concentrations during pregnancy and postpartum.
Songmao Zheng; Justina C Calamia; Connie L Davis; Mary F Hebert; Yvonne S Lin; Danny D Shen; Yoshihisa Shitara; Yasar Tasnif; Kenneth E Thummel
CYP3A5 gene variation influences cyclosporine A metabolite formation and renal cyclosporine disposition.

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2013: Zhican Wang; Connie L Davis; Leslie J Dickmann; David L Eaton; Johanna W Lampe; Yvonne S Lin; Emma-Jane Poulton; Danny D Shen; Margaret C Shuhart; Kenneth E Thummel
Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D3 through CYP3A4 induction in vitro and in vivo: Implications for drug-induced osteomalacia.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013;28(5):1101-16.
2013: Mary F Hebert; Menachem Miodovnik; Danny D Shen; Kenneth E Thummel; Jason G Umans; Songmao Zheng; Connie L Davis; Karen Hays; Thomas R Easterling
Interpreting tacrolimus concentrations during pregnancy and postpartum.
Transplantation 2013;95(7):908-15.
2013: Songmao Zheng; Justina C Calamia; Connie L Davis; Mary F Hebert; Yvonne S Lin; Danny D Shen; Yoshihisa Shitara; Yasar Tasnif; Kenneth E Thummel
CYP3A5 gene variation influences cyclosporine A metabolite formation and renal cyclosporine disposition.
Transplantation 2013;95(6):821-7.
2013: Paul E Baker; Megan Cartwright; Aila L Co; Toby B Cole; Jerry H Kim; Yvonne S Lin; Allan E Rettie; Stephanie M Suzuki; Kenneth E Thummel; Clement E Furlong
Identifying safer anti-wear triaryl phosphate additives for jet engine lubricants.
Chemico-biological interactions 2013;203(1):257-64.
2013: Nina Isoherranen; Kenneth E Thummel
Drug metabolism and transport during pregnancy: how does drug disposition change during pregnancy and what are the mechanisms that cause such changes?
Drug metabolism and disposition: the biological fate of chemicals 2013;41(2):256-62.
2013: Diana L Shuster; Kenneth E Thummel; Jesse M Tsai; Theo K Bammler; Richard P Beyer; Frederico M Farin; Mary F Hebert; James W Macdonald; Qingcheng Mao
Gestational age-dependent changes in gene expression of metabolic enzymes and transporters in pregnant mice.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(2):332-42.
2013: Emma Jane Poulton; Danny D Shen; Margaret C Shuhart; Kenneth E Thummel; Julia Tracy; Johanna W Lampe; Lisa Levy; David L Eaton
Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo.
Toxicology and applied pharmacology 2013;266(1):122-31.
2012: S Zheng; Justina C Calamia; C L Davis; Mary F Hebert; Yvonne S Lin; Danny D Shen; Y Shitara; Y Tasnif; Kenneth E Thummel
Measurement and compartmental modeling of the effect of CYP3A5 gene variation on systemic and intrarenal tacrolimus disposition.
Clinical pharmacology and therapeutics 2012;92(6):737-45.
2012: Songmao Zheng; Justina C Calamia; Connie L Davis; Thomas R Easterling; Menachem Miodovnik; Danny D Shen; Kenneth E Thummel; Jason G Umans; Mary F Hebert
Pharmacokinetics of tacrolimus during pregnancy.
Therapeutic drug monitoring 2012;34(6):660-70.
2012: Thomas J Laha; Frederick G Strathmann; Kenneth E Thummel; Zhican Wang; Ian H de Boer; Andrew N Hoofnagle
Characterizing antibody cross-reactivity for immunoaffinity purification of analytes prior to multiplexed liquid chromatography-tandem mass spectrometry.
Clinical chemistry 2012;58(12):1711-6.
2012: Xi Emily Zheng; Zhican Wang; Michael Z Liao; Yvonne S Lin; Erin G Schuetz; Margaret C Shuhart; Kenneth E Thummel
Human PXR-mediated induction of intestinal CYP3A4 attenuates 1α,25-dihydroxyvitamin D₃ function in human colon adenocarcinoma LS180 cells.
Biochemical pharmacology 2012;84(3):391-401.
2012: Ranjit K Thirumaran; Kenneth E Thummel; Brad L Urquhart; Nilesh Chande; Cheng Cheng; Yiping Fan; Jamie C Gregor; Stephen D Hall; Richard B Kim; Jatinder K Lamba; An Qi; Erin G Schuetz
Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation.
Biochemical pharmacology 2012;84(1):104-12.
2012: Zhican Wang; Xi Emily Zheng; Thomas A Baillie; David Blough; Connie L Davis; Leslie J Dickmann; Takanori Hashizume; Mary F Hebert; Yvonne S Lin; Sidney D Nelson; Michele Scian; T Senn; Kenneth E Thummel
An inducible cytochrome P450 3A4-dependent vitamin D catabolic pathway.
Molecular pharmacology 2012;81(4):498-509.
2012: Brian J Kirby; Kenneth E Thummel; Ann C Collier; Evan D Kharasch; Dale Whittington; Jashvant D Unadkat
Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(3):610-6.
2012: J Yang; W M Atkins; Nina Isoherranen; Mary F Paine; Kenneth E Thummel
Evidence of CYP3A allosterism in vivo: analysis of interaction between fluconazole and midazolam.
Clinical pharmacology and therapeutics 2012;91(3):442-9.
2011: Brian J Kirby; Kenneth E Thummel; Dale Whittington; Ann C Collier; Pankaj Desai; Vaishali Dixit; Evan D Kharasch; Jashvant D Unadkat
Complex drug interactions of HIV protease inhibitors 2: in vivo induction and in vitro to in vivo correlation of induction of cytochrome P450 1A2, 2B6, and 2C9 by ritonavir or nelfinavir.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(12):2329-37.
2011: Zhican Wang; Songmao Zheng; Xi Emily Zheng; Connie L Davis; Mary F Hebert; Thomas F Kalhorn; Yvonne S Lin; T Senn; Kenneth E Thummel
Simultaneous measurement of plasma vitamin D(3) metabolites, including 4β,25-dihydroxyvitamin D(3), using liquid chromatography-tandem mass spectrometry.
Analytical biochemistry 2011;418(1):126-33.
2011: C-C Peng; I Templeton; Kenneth E Thummel; C Davis; Kent L Kunze; Nina Isoherranen
Evaluation of 6β-hydroxycortisol, 6β-hydroxycortisone, and a combination of the two as endogenous probes for inhibition of CYP3A4 in vivo.
Clinical pharmacology and therapeutics 2011;89(6):888-95.
2011: Brian J Kirby; Ann C Collier; Evan D Kharasch; Dale Whittington; Kenneth E Thummel; Jashvant D Unadkat
Complex drug interactions of HIV protease inhibitors 1: inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(6):1070-8.
2010: I Templeton; C-C Peng; Kenneth E Thummel; C Davis; Kent L Kunze; Nina Isoherranen
Accurate prediction of dose-dependent CYP3A4 inhibition by itraconazole and its metabolites from in vitro inhibition data.
Clinical pharmacology and therapeutics 2010;88(4):499-505.
2010: Suresh Babu Naraharisetti; Yvonne S Lin; Mark J Rieder; Kristin D Marciante; Bruce M Psaty; Kenneth E Thummel; Rheem A Totah
Human liver expression of CYP2C8: gender, age, and genotype effects.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(6):889-93.
2009: Kerryn W Reding; Noel S Weiss; Chu Chen; Christopher I Li; Christopher S Carlson; Hui-Wen Wilkerson; Federico M Farin; Kenneth E Thummel; Janet R Daling; Kathleen E Malone
Genetic polymorphisms in the catechol estrogen metabolism pathway and breast cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009;18(5):1461-7.
2009: D J McConn; Yvonne S Lin; T L Mathisen; D K Blough; Y Xu; T Hashizume; S L Taylor; Kenneth E Thummel; Margaret C Shuhart
Reduced duodenal cytochrome P450 3A protein expression and catalytic activity in patients with cirrhosis.
Clinical pharmacology and therapeutics 2009;85(4):387-93.
2008: Helen E Smith; J P Jones; Thomas F Kalhorn; Federico M Farin; Patricia L Stapleton; Connie L Davis; James D Perkins; David K Blough; Mary F Hebert; Kenneth E Thummel; Rheem A Totah
Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease.
Pharmacogenetics and genomics 2008;18(11):943-53.
2008: Mary F Hebert; Thomas R Easterling; B Kirby; Daniel B Carr; M L Buchanan; T Rutherford; Kenneth E Thummel; D P Fishbein; J D Unadkat
Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study.
Clinical pharmacology and therapeutics 2008;84(2):248-53.
2008: Anshul Gupta; Ganesh M Mugundu; Pankaj B Desai; Kenneth E Thummel; Jashvant D Unadkat
Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(6):1172-80.
2008: Balasubramanian Poonkuzhali; Jatinder Lamba; Stephen Strom; Alex Sparreboom; Kenneth E Thummel; Paul B Watkins; Erin G Schuetz
Association of breast cancer resistance protein/ABCG2 phenotypes and novel promoter and intron 1 single nucleotide polymorphisms.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(4):780-95.
2008: Rheem A Totah; Pamela Sheffels; Toni Roberts; Dale Whittington; Kenneth E Thummel; Evan D Kharasch
Role of CYP2B6 in stereoselective human methadone metabolism.
Anesthesiology 2008;108(3):363-74.
2008: Takanori Hashizume; Yang Xu; Michael A Mohutsky; Jeffrey Alberts; Chad Hadden; Thomas F Kalhorn; Nina Isoherranen; Margaret C Shuhart; Kenneth E Thummel
Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1alpha,25-dihydroxyvitamin D3 conjugation.
Biochemical pharmacology 2008;75(5):1240-50.
2008: Nina Isoherranen; Shana R Ludington; Raymond C Givens; Jatinder Lamba; Susan N Pusek; Elizabeth Dees; David K Blough; Kazunori Iwanaga; Roy L Hawke; Erin G Schuetz; Paul B Watkins; Kenneth E Thummel; Mary F Paine
The influence of CYP3A5 expression on the extent of hepatic CYP3A inhibition is substrate-dependent: an in vitro-in vivo evaluation.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(1):146-54.
2008: I E Templeton; Kenneth E Thummel; Evan D Kharasch; Kent L Kunze; Christine Hoffer; Wendel L Nelson; Nina Isoherranen
Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo.
Clinical pharmacology and therapeutics 2008;83(1):77-85.
2007: Kenneth E Thummel
Gut instincts: CYP3A4 and intestinal drug metabolism.
The Journal of clinical investigation 2007;117(11):3173-6.
2007: Vaishali Dixit; Niresh Hariparsad; Fang Li; Pankaj Desai; Kenneth E Thummel; Jashvant D Unadkat
Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(10):1853-9.
2007: Evan D Kharasch; Alysa Walker; Nina Isoherranen; Christine Hoffer; Pamela Sheffels; Kenneth E Thummel; Dale Whittington; D Ensign
Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam.
Clinical pharmacology and therapeutics 2007;82(4):410-26.
2007: Weili Huang; Thomas F Kalhorn; Mark Baillie; Danny D Shen; Kenneth E Thummel
Determination of free and total cortisol in plasma and urine by liquid chromatography-tandem mass spectrometry.
Therapeutic drug monitoring 2007;29(2):215-24.
2007: Changcheng Zhou; Emma-Jane Poulton; Felix Grün; Theo K Bammler; Bruce Blumberg; Kenneth E Thummel; David Eaton
The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor.
Molecular pharmacology 2007;71(1):220-9.
2006: Anshul Gupta; Yang Dai; R Robert Vethanayagam; Mary F Hebert; Kenneth E Thummel; Jashvant D Unadkat; Douglas Ross; Qingcheng Mao
Cyclosporin A, tacrolimus and sirolimus are potent inhibitors of the human breast cancer resistance protein (ABCG2) and reverse resistance to mitoxantrone and topotecan.
Cancer chemotherapy and pharmacology 2006;58(3):374-83.
2006: Changcheng Zhou; Michelle M Tabb; Edward L Nelson; Felix Grün; Suman Verma; Sally Rafie; Min Lin; Shyamali Mallick; Barry M Forman; Kenneth E Thummel; Bruce Blumberg
Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation.
The Journal of clinical investigation 2006;116(8):2280-2289.
2006: Yang Xu; Kazunori Iwanaga; Changcheng Zhou; Matthew J Cheesman; Federico M Farin; Kenneth E Thummel
Selective induction of intestinal CYP3A23 by 1alpha,25-dihydroxyvitamin D3 in rats.
Biochemical pharmacology 2006;72(3):385-92.
2006: Changcheng Zhou; Mahfoud Assem; Jessica C Tay; Paul B Watkins; Bruce Blumberg; Erin G Schuetz; Kenneth E Thummel
Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia.
The Journal of clinical investigation 2006;116(6):1703-12.
2006: Yang Dai; Mary F Hebert; Nina Isoherranen; Connie L Davis; Christopher Marsh; Danny D Shen; Kenneth E Thummel
Effect of CYP3A5 polymorphism on tacrolimus metabolic clearance in vitro.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(5):836-47.
2006: Jatinder Lamba; Stephen Strom; Raman Venkataramanan; Kenneth E Thummel; Yvonne S Lin; Wei Liu; Cheng Cheng; Vishal Lamba; Paul B Watkins; Erin G Schuetz
MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype.
Clinical pharmacology and therapeutics 2006;79(4):325-38.
2006: Kent L Kunze; Wendel L Nelson; Evan D Kharasch; Kenneth E Thummel; Nina Isoherranen
Stereochemical aspects of itraconazole metabolism in vitro and in vivo.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(4):583-90.
2006: Yang Xu; Takanori Hashizume; Margaret C Shuhart; Connie L Davis; Wendel L Nelson; Toshiyuki Sakaki; Thomas F Kalhorn; Paul B Watkins; Erin G Schuetz; Kenneth E Thummel
Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia.
Molecular pharmacology 2006;69(1):56-65.
2005: Jeannine S McCune; Linda Risler; Brian R Phillips; Kenneth E Thummel; David K Blough; Danny D Shen
Contribution of CYP3A5 to hepatic and renal ifosfamide N-dechloroethylation.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(7):1074-81.
2005: Mark J Rieder; Alexander P Reiner; Brian F Gage; Deborah A Nickerson; Charles Eby; howard mcleod; David K Blough; Kenneth E Thummel; David L Veenstra; Allan E Rettie
Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose.
The New England journal of medicine 2005;352(22):2285-93.
2005: Evan D Kharasch; Kenneth E Thummel; Paul B Watkins
CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibition.
Molecular interventions 2005;5(3):151-3.
2005: Theresa Mariero Klees; Pamela Sheffels; Kenneth E Thummel; Evan D Kharasch
Pharmacogenetic determinants of human liver microsomal alfentanil metabolism and the role of cytochrome P450 3A5.
Anesthesiology 2005;102(3):550-6.
2004: Weili Huang; Yvonne S Lin; Donavon J McConn; Justina C Calamia; Rheem A Totah; Nina Isoherranen; Mary Glodowski; Kenneth E Thummel
Evidence of significant contribution from CYP3A5 to hepatic drug metabolism.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(12):1434-45.
2004: Yang Dai; Kazunori Iwanaga; Yvonne S Lin; Mary F Hebert; Connie L Davis; Weili Huang; Evan D Kharasch; Kenneth E Thummel
In vitro metabolism of cyclosporine A by human kidney CYP3A5.
Biochemical pharmacology 2004;68(9):1889-902.
2004: Donavon J McConn; Yvonne S Lin; Kyle Allen; Kent L Kunze; Kenneth E Thummel
Differences in the inhibition of cytochromes P450 3A4 and 3A5 by metabolite-inhibitor complex-forming drugs.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(10):1083-91.
2004: Nina Isoherranen; Kent L Kunze; Kyle E Allen; Wendel L Nelson; Kenneth E Thummel
Role of itraconazole metabolites in CYP3A4 inhibition.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(10):1121-31.
2004: Lisa A McConnachie; Miklos Bodor; Kris Kowdley; Adam Levy; Bruce Tung; Kenneth E Thummel; Brian Phillips; Manoj Bajpai; Victor Chi; Joel D Esmay; Danny D Shen; Rodney J Y Ho
Human liver cytochrome P450 2D6 genotype, full-length messenger ribonucleic acid, and activity assessed with a novel cytochrome P450 2D6 substrate.
Clinical pharmacology and therapeutics 2004;75(4):282-97.
2004: Kenneth E Thummel
A genetic test for immunosuppressant dose selection?
Pharmacogenetics 2004;14(3):145-6.
2003: Mary F Hebert; Amy L Dowling; Cynthia Gierwatowski; Yvonne S Lin; Karen L Edwards; Connie L Davis; Christopher L Marsh; Erin G Schuetz; Kenneth E Thummel
Association between ABCB1 (multidrug resistance transporter) genotype and post-liver transplantation renal dysfunction in patients receiving calcineurin inhibitors.
Pharmacogenetics 2003;13(11):661-74.
2003: Kenneth E Thummel
Does the CYP3A5*3 polymorphism affect in vivo drug elimination?
Pharmacogenetics 2003;13(10):585-7.
2003: Raymond C Givens; Yvonne S Lin; Amy L S Dowling; Kenneth E Thummel; Jatinder Lamba; Erin G Schuetz; Paul W. Stewart; Paul B Watkins
CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;95(3):1297-300.
2003: Maurice G Emery; Jeannine M Fisher; Jenny Y Chien; Evan D Kharasch; E Patchen Dellinger; Kris V Kowdley; Kenneth E Thummel
CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease.
Hepatology (Baltimore, Md.) 2003;38(2):428-35.
2003: DK Spracklin; M E Emery; Kenneth E Thummel; Evan D Kharasch
Concordance between trifluoroacetic acid and hepatic protein trifluoroacetylation after disulfiram inhibition of halothane metabolism in rats.
Acta anaesthesiologica Scandinavica 2003;47(6):765-70.
2003: Jeong M Park; Yvonne S Lin; Justina C Calamia; Kenneth E Thummel; John T Slattery; Thomas F Kalhorn; Robert L Carithers; Adam E Levy; Christopher L Marsh; Mary F Hebert
Transiently altered acetaminophen metabolism after liver transplantation.
Clinical pharmacology and therapeutics 2003;73(6):545-53.
2003: Charis P Zamber; Jatinder Lamba; Kazuto Yasuda; Jennifer Farnum; Kenneth E Thummel; John D Schuetz; Erin G Schuetz
Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine.
Pharmacogenetics 2003;13(1):19-28.
2002: Jatinder Lamba; Yvonne S Lin; Erin G Schuetz; Kenneth E Thummel
Genetic contribution to variable human CYP3A-mediated metabolism.
Advanced drug delivery reviews 2002;54(10):1271-94.
2002: Yvonne S Lin; Amy L S Dowling; Sean D Quigley; Federico M Farin; Jiong Zhang; Jatinder Lamba; Erin G Schuetz; Kenneth E Thummel
Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism.
Molecular pharmacology 2002;62(1):162-72.
2002: Mary F Paine; Louis Y Leung; H K Lim; Kecheng Liao; Aram Oganesian; Mei-Yi Zhang; Kenneth E Thummel; Paul B Watkins
Identification of a novel route of extraction of sirolimus in human small intestine: roles of metabolism and secretion.
The Journal of pharmacology and experimental therapeutics 2002;301(1):174-86.
2002: Jatinder Lamba; Yvonne S Lin; Kenneth E Thummel; Ann Daly; Paul B Watkins; Stephen Strom; Jiong Zhang; Erin G Schuetz
Common allelic variants of cytochrome P4503A4 and their prevalence in different populations.
Pharmacogenetics 2002;12(2):121-32.
2001: Yvonne S Lin; Graham F Lockwood; Martin A Graham; W R Brian; C M Loi; M R Dobrinska; Danny D Shen; Paul B Watkins; G R Wilkinson; Evan D Kharasch; Kenneth E Thummel
In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration.
Pharmacogenetics 2001;11(9):781-91.
2001: Kenneth E Thummel; C Brimer; Kazuto Yasuda; J Thottassery; T Senn; Y Lin; H Ishizuka; Evan D Kharasch; John D Schuetz; Erin G Schuetz
Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3.
Molecular pharmacology 2001;60(6):1399-406.
2001: Phyllissa Schmiedlin-Ren; Kenneth E Thummel; Jeannine M Fisher; Mary F Paine; Paul B Watkins
Induction of CYP3A4 by 1 alpha,25-dihydroxyvitamin D3 is human cell line-specific and is unlikely to involve pregnane X receptor.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(11):1446-53.
2001: J Zhang; PM Kuehl; Eric Green; Jeffrey W Touchman; Paul B Watkins; A Daly; S D Hall; P Maurel; Mary Relling; C Brimer; Kazuto Yasuda; S A Wrighton; M Hancock; Richard B Kim; Stephen Strom; Kenneth E Thummel; C G Russell; J R Hudson; Erin G Schuetz; Mark S Boguski
The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants.
Pharmacogenetics 2001;11(7):555-72.
2000: H Dong; Robert L Haining; Kenneth E Thummel; Allan E Rettie; Sidney D Nelson
Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(12):1397-400.
2000: Mary F Paine; Connie L Davis; Danny D Shen; Christopher L Marsh; Vidmantas A Raisys; Kenneth E Thummel
Can oral midazolam predict oral cyclosporine disposition?
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;12(1):51-62.
2000: Catherine K Yeung; DH Lang; Kenneth E Thummel; Allan E Rettie
Immunoquantitation of FMO1 in human liver, kidney, and intestine.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(9):1107-11.
2000: Kenneth E Thummel; John T Slattery; H Ro; Jenny Y Chien; Sidney D Nelson; K E Lown; Paul B Watkins
Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults.
Clinical pharmacology and therapeutics 2000;67(6):591-9.
2000: MA Gibbs; M T Baillie; Danny D Shen; Kent L Kunze; Kenneth E Thummel
Persistent inhibition of CYP3A4 by ketoconazole in modified Caco-2 cells.
Pharmaceutical research 2000;17(3):299-305.
1999: M G Emery; C Jubert; Kenneth E Thummel; Evan D Kharasch
Duration of cytochrome P-450 2E1 (CYP2E1) inhibition and estimation of functional CYP2E1 enzyme half-life after single-dose disulfiram administration in humans.
The Journal of pharmacology and experimental therapeutics 1999;291(1):213-9.
1999: S Madani; Mary F Paine; L Lewis; Kenneth E Thummel; Danny D Shen
Comparison of CYP2D6 content and metoprolol oxidation between microsomes isolated from human livers and small intestines.
Pharmaceutical research 1999;16(8):1199-205.
1999: Evan D Kharasch; C Jubert; T Senn; T A Bowdle; Kenneth E Thummel
Intraindividual variability in male hepatic CYP3A4 activity assessed by alfentanil and midazolam clearance.
Journal of clinical pharmacology 1999;39(7):664-9.
1999: Evan D Kharasch; DC Hankins; C Jubert; Kenneth E Thummel; JK Taraday
Lack of single-dose disulfiram effects on cytochrome P-450 2C9, 2C19, 2D6, and 3A4 activities: evidence for specificity toward P-450 2E1.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(6):717-23.
1999: MA Gibbs; Kent L Kunze; William N Howald; Kenneth E Thummel
Effect of inhibitor depletion on inhibitory potency: tight binding inhibition of CYP3A by clotrimazole.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(5):596-9.
1999: Jeannine M Fisher; S A Wrighton; Justina C Calamia; Danny D Shen; Kent L Kunze; Kenneth E Thummel
Midazolam metabolism by modified Caco-2 monolayers: effects of extracellular protein binding.
The Journal of pharmacology and experimental therapeutics 1999;289(2):1143-50.
1999: Jeannine M Fisher; S A Wrighton; Paul B Watkins; Phyllissa Schmiedlin-Ren; Justina C Calamia; Danny D Shen; Kent L Kunze; Kenneth E Thummel
First-pass midazolam metabolism catalyzed by 1alpha,25-dihydroxy vitamin D3-modified Caco-2 cell monolayers.
The Journal of pharmacology and experimental therapeutics 1999;289(2):1134-42.
1999: MA Gibbs; Kenneth E Thummel; Danny D Shen; Kent L Kunze
Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(2):180-7.
1999: Stephen D Hall; Kenneth E Thummel; Paul B Watkins; Kenneth S Lown; L Z Benet; Mary F Paine; R R Mayo; D Kim Turgeon; DG Bailey; Robert J Fontana; Steven A Wrighton
Molecular and physical mechanisms of first-pass extraction.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(2):161-6.
1998: Evan D Kharasch; DC Hankins; PJ Baxter; Kenneth E Thummel
Single-dose disulfiram does not inhibit CYP2A6 activity.
Clinical pharmacology and therapeutics 1998;64(1):39-45.
1998: Kenneth E Thummel; G R Wilkinson
In vitro and in vivo drug interactions involving human CYP3A.
Annual review of pharmacology and toxicology 1998;38():389-430.
1997: Mary F Paine; M Khalighi; Jeannine M Fisher; Danny D Shen; Kent L Kunze; Christopher L Marsh; J D Perkins; Kenneth E Thummel
Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism.
The Journal of pharmacology and experimental therapeutics 1997;283(3):1552-62.
1997: Agnès Tran; Elisabeth Rey; Gérard Pons; M Rousseau; Philippe d'Athis; Georges Olive; Gary Mather; FE Bishop; colleen johnson wurden; RB Labroo; William F Trager; Kent L Kunze; Kenneth E Thummel; J C Vincent; JM Gillardin; F Lepage; René H Levy
Influence of stiripentol on cytochrome P450-mediated metabolic pathways in humans: in vitro and in vivo comparison and calculation of in vivo inhibition constants.
Clinical pharmacology and therapeutics 1997;62(5):490-504.
1997: Phyllissa Schmiedlin-Ren; David J Edwards; M E Fitzsimmons; Kan He; Kenneth S Lown; Patrick M Woster; A Rahman; Kenneth E Thummel; Jeannine M Fisher; Paul Hollenberg; Paul B Watkins
Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(11):1228-33.
1997: Jenny Y Chien; Kenneth E Thummel; John T Slattery
Pharmacokinetic consequences of induction of CYP2E1 by ligand stabilization.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(10):1165-75.
1997: C A Lee; P T Manyike; Kenneth E Thummel; Sidney D Nelson; John T Slattery
Mechanism of cytochrome P450 activation by caffeine and 7,8-benzoflavone in rat liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(10):1150-6.
1997: RB Labroo; Mary F Paine; Kenneth E Thummel; Evan D Kharasch
Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, efficacy, and drug interactions.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(9):1072-80.
1997: Evan D Kharasch; M Russell; DS Mautz; Kenneth E Thummel; K L Kunze; A Bowdle; K Cox
The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions.
Anesthesiology 1997;87(1):36-50.
1997: Phyllissa Schmiedlin-Ren; Kenneth E Thummel; Jeannine M Fisher; Mary F Paine; Kenneth S Lown; Paul B Watkins
Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3.
Molecular pharmacology 1997;51(5):741-54.
1997: DK Spracklin; DC Hankins; Jeannine M Fisher; Kenneth E Thummel; Evan D Kharasch
Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro.
The Journal of pharmacology and experimental therapeutics 1997;281(1):400-11.
1997: Jenny Y Chien; Raimund Peter; Charles M Nolan; C Wartell; John T Slattery; Sidney D Nelson; Robert L Carithers; Kenneth E Thummel
Influence of polymorphic N-acetyltransferase phenotype on the inhibition and induction of acetaminophen bioactivation with long-term isoniazid.
Clinical pharmacology and therapeutics 1997;61(1):24-34.
1996: W Chen; Raimund Peter; Susan McArdle; Kenneth E Thummel; R O Sigle; Sidney D Nelson
Baculovirus expression and purification of human and rat cytochrome P450 2E1.
Archives of biochemistry and biophysics 1996;335(1):123-30.
1996: S K Janardan; Kenneth S Lown; Phyllissa Schmiedlin-Ren; Kenneth E Thummel; Paul B Watkins
Selective expression of CYP3A5 and not CYP3A4 in human blood.
Pharmacogenetics 1996;6(5):379-85.
1996: DK Spracklin; Kenneth E Thummel; Evan D Kharasch
Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(9):976-83.
1996: John T Slattery; Sidney D Nelson; Kenneth E Thummel
The complex interaction between ethanol and acetaminophen.
Clinical pharmacology and therapeutics 1996;60(3):241-6.
1996: Mary F Paine; Danny D Shen; Kent L Kunze; James D Perkins; Christopher L Marsh; John P McVicar; D M Barr; B S Gillies; Kenneth E Thummel
First-pass metabolism of midazolam by the human intestine.
Clinical pharmacology and therapeutics 1996;60(1):14-24.
1996: Evan D Kharasch; DC Hankins; DS Mautz; Kenneth E Thummel
Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis.
Lancet 1996;347(9012):1367-71.
1996: Kenneth E Thummel; D O'Shea; Mary F Paine; Danny D Shen; Kent L Kunze; James D Perkins; G R Wilkinson
Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.
Clinical pharmacology and therapeutics 1996;59(5):491-502.
1996: Kent L Kunze; L C Wienkers; Kenneth E Thummel; William F Trager
Warfarin-fluconazole. I. Inhibition of the human cytochrome P450-dependent metabolism of warfarin by fluconazole: in vitro studies.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(4):414-21.
1996: A K Mitra; Kenneth E Thummel; Thomas F Kalhorn; Evan D Kharasch; Jashvant D Unadkat; John T Slattery
Inhibition of sulfamethoxazole hydroxylamine formation by fluconazole in human liver microsomes and healthy volunteers.
Clinical pharmacology and therapeutics 1996;59(3):332-40.
1995: Kyle J Garton; P Yuen; J Meinwald; Kenneth E Thummel; Evan D Kharasch
Stereoselective metabolism of enflurane by human liver cytochrome P450 2E1.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(12):1426-30.
1995: A K Mitra; Kenneth E Thummel; Thomas F Kalhorn; Evan D Kharasch; Jashvant D Unadkat; John T Slattery
Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo.
Clinical pharmacology and therapeutics 1995;58(5):556-66.
1995: R B Labroo; Kenneth E Thummel; Kent L Kunze; T Podoll; William F Trager; Evan D Kharasch
Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(4):490-6.
1995: Evan D Kharasch; DC Hankins; Kenneth E Thummel
Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity.
Anesthesiology 1995;82(3):689-99.
1995: Kenneth S Lown; Kenneth E Thummel; Patrick E Benedict; D D Shen; D Kim Turgeon; S Berent; Paul B Watkins
The erythromycin breath test predicts the clearance of midazolam.
Clinical pharmacology and therapeutics 1995;57(1):16-24.
1994: Kenneth S Lown; Joseph C Kolars; Kenneth E Thummel; J L Barnett; Kent L Kunze; Steven A Wrighton; Paul B Watkins
Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(6):947-55.
1994: Kenneth E Thummel; Danny D Shen; T D Podoll; Kent L Kunze; William F Trager; C E Bacchi; Christopher L Marsh; John P McVicar; D M Barr; James D Perkins
Use of midazolam as a human cytochrome P450 3A probe: II. Characterization of inter- and intraindividual hepatic CYP3A variability after liver transplantation.
The Journal of pharmacology and experimental therapeutics 1994;271(1):557-66.
1994: Kenneth E Thummel; Danny D Shen; T D Podoll; Kent L Kunze; William F Trager; P S Hartwell; V A Raisys; Christopher L Marsh; John P McVicar; D M Barr
Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients.
The Journal of pharmacology and experimental therapeutics 1994;271(1):549-56.
1994: Evan D Kharasch; Kenneth E Thummel; DS Mautz; S Bosse
Clinical enflurane metabolism by cytochrome P450 2E1.
Clinical pharmacology and therapeutics 1994;55(4):434-40.
1994: Timothy G Myers; Kenneth E Thummel; Thomas F Kalhorn; Sidney D Nelson
Preferred orientations in the binding of 4'-hydroxyacetanilide (acetaminophen) to cytochrome P450 1A1 and 2B1 isoforms as determined by 13C- and 15N-NMR relaxation studies.
Journal of medicinal chemistry 1994;37(6):860-7.
1993: Evan D Kharasch; Kenneth E Thummel
Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane.
Anesthesiology 1993;79(4):795-807.
1993: R Zand; S D Nelson; John T Slattery; Kenneth E Thummel; Thomas F Kalhorn; S P Adams; JM Wright
Inhibition and induction of cytochrome P4502E1-catalyzed oxidation by isoniazid in humans.
Clinical pharmacology and therapeutics 1993;54(2):142-9.
1993: Evan D Kharasch; Kenneth E Thummel; Jill M Mhyre; J H Lillibridge
Single-dose disulfiram inhibition of chlorzoxazone metabolism: a clinical probe for P450 2E1.
Clinical pharmacology and therapeutics 1993;53(6):643-50.
1993: Evan D Kharasch; Kenneth E Thummel
Human alfentanil metabolism by cytochrome P450 3A3/4. An explanation for the interindividual variability in alfentanil clearance?
Anesthesia and analgesia 1993;76(5):1033-9.
1993: Kenneth E Thummel; C A Lee; Kent L Kunze; Sidney D Nelson; John T Slattery
Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4.
Biochemical pharmacology 1993;45(8):1563-9.
1993: Kenneth E Thummel; Evan D Kharasch; T Podoll; K Kunze
Human liver microsomal enflurane defluorination catalyzed by cytochrome P-450 2E1.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(2):350-7.
1991: C A Lee; Kenneth E Thummel; Thomas F Kalhorn; Sidney D Nelson; John T Slattery
Activation of acetaminophen-reactive metabolite formation by methylxanthines and known cytochrome P-450 activators.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(5):966-71.
1991: John T Slattery; Thomas F Kalhorn; Kenneth E Thummel
Mechanisms by which acetaminophen administration diminishes ethanol clearance.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(2):558-60.
1991: C A Lee; Kenneth E Thummel; Thomas F Kalhorn; Sidney D Nelson; John T Slattery
Inhibition and activation of acetaminophen reactive metabolite formation by caffeine. Roles of cytochromes P-450IA1 and IIIA2.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(2):348-53.
1988: Kenneth E Thummel; John T Slattery; Sidney D Nelson
Mechanism by which ethanol diminishes the hepatotoxicity of acetaminophen.
The Journal of pharmacology and experimental therapeutics 1988;245(1):129-36.
1986: Robert E Vestal; Kenneth E Thummel; G D Mercer; J R Koup
Comparison of single and multiple dose pharmacokinetics of theophylline using stable isotopes.
European journal of clinical pharmacology 1986;30(1):113-20.
1983: Robert E Vestal; Kenneth E Thummel; B Musser; G D Mercer
Cimetidine inhibits theophylline clearance in patients with chronic obstructive pulmonary disease: a study using stable isotope methodology during multiple oral dose administration.
British journal of clinical pharmacology 1983;15(4):411-8.
1982: Robert E Vestal; Kenneth E Thummel; B Musser; S G Jue; G D Mercer; William N Howald
Stable isotope methodology in a pharmacokinetic study of the interaction of theophylline and cimetidine.
Biomedical mass spectrometry 1982;9(8):340-6.