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Chantal Thys

Research Profile

Anatomy

Chemicals & Drugs

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Thrombocytopenia

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Sophie Louwette; Luc Régal; Chantal Thys; Chris Van Geet; Gwenny Vandeweeghde; Christine Wittevrongel; Rita De Vos; Elisa Decuyper; Jaak Jaeken; Peter Leemans; Kathleen Freson
NPC1 defect results in abnormal platelet formation and function: studies in Niemann-Pick disease type C1 patients and zebrafish.
Christophe Goubau; Jaak Jaeken; Elena N Levtchenko; Geert A Martens; Chantal Thys; Chris Van Geet; Gunnar M Buyse; Rita De Vos; Michela Di Michele; Erik Gerlo; Nathalie Goemans; Kathleen Freson
Homozygosity for aquaporin 7 G264V in three unrelated children with hyperglyceroluria and a mild platelet secretion defect.
Sophie Louwette; Juriaan Metz; Chantal Thys; Chris Van Geet; Christine Wittevrongel; Jef Arnout; zeger debyser; Rik Gijsbers; Valery Labarque; Kathleen Freson
Regulator of G-protein signaling 18 controls megakaryopoiesis and the cilia-mediated vertebrate mechanosensory system.

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All Publications

2013: Sophie Louwette; Luc Régal; Chantal Thys; Chris Van Geet; Gwenny Vandeweeghde; Christine Wittevrongel; Rita De Vos; Elisa Decuyper; Jaak Jaeken; Peter Leemans; Kathleen Freson
NPC1 defect results in abnormal platelet formation and function: studies in Niemann-Pick disease type C1 patients and zebrafish.
Human molecular genetics 2013;22(1):61-73.
2013: Christophe Goubau; Jaak Jaeken; Elena N Levtchenko; Geert A Martens; Chantal Thys; Chris Van Geet; Gunnar M Buyse; Rita De Vos; Michela Di Michele; Erik Gerlo; Nathalie Goemans; Kathleen Freson
Homozygosity for aquaporin 7 G264V in three unrelated children with hyperglyceroluria and a mild platelet secretion defect.
Genetics in medicine : official journal of the American College of Medical Genetics 2013;15(1):55-63.
2012: Sophie Louwette; Juriaan Metz; Chantal Thys; Chris Van Geet; Christine Wittevrongel; Jef Arnout; zeger debyser; Rik Gijsbers; Valery Labarque; Kathleen Freson
Regulator of G-protein signaling 18 controls megakaryopoiesis and the cilia-mediated vertebrate mechanosensory system.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(5):2125-36.
2012: Benedetta Izzi; Chantal Thys; Chris Van Geet; Christine Wittevrongel; Francis de Zegher; Jurgen del Favero; I Francois; Dirk Goossens; Kathleen Freson
No evidence for GNAS copy number variants in patients with features of Albright's hereditary osteodystrophy and abnormal platelet Gs activity.
Journal of human genetics 2012;57(4):277-9.
2012: Benedetta Izzi; Valery Labarque; Diether Lambrechts; Eric Legius; Chantal Thys; Annick Van den Bruel; Chris Van Geet; Christine Wittevrongel; Francis de Zegher; Koen Devriendt; Marc D'Hooghe; I Francois; Kathleen Freson
Methylation defect in imprinted genes detected in patients with an Albright's hereditary osteodystrophy like phenotype and platelet Gs hypofunction.
PloS one 2012;7(6):e38579.
2011: Michela Di Michele; Chantal Thys; Etienne Waelkens; Lut Overbergh; Wannes D'Hertog; Chantal Mathieu; Rita De Vos; Kathelijne Peerlinck; Chris Van Geet; Kathleen Freson
An integrated proteomics and genomics analysis to unravel a heterogeneous platelet secretion defect.
Journal of proteomics 2011;74(6):902-13.
2010: L Noé; M Di Michele; E Giets; Chantal Thys; Christine Wittevrongel; Rita De Vos; Lut Overbergh; E Waelkens; Jaak Jaeken; C Van Geet; Kathleen Freson
Platelet Gs hypofunction and abnormal morphology resulting from a heterozygous RGS2 mutation.
Journal of thrombosis and haemostasis : JTH 2010;8(7):1594-603.
2010: Liesbeth de Waele; Kathleen Freson; Sophie Louwette; Chantal Thys; Christine Wittevrongel; Rita De Vos; Anne Debeer; Chris Van Geet
Severe gastrointestinal bleeding and thrombocytopenia in a child with an anti-GATA1 autoantibody.
Pediatric research 2010;67(3):314-9.
2008: Kathleen Freson; Benedetta Izzi; Veerle Labarque; Maria van Helvoirt; Chantal Thys; Christine Wittevrongel; Marie Bex; Roger Bouillon; Nathalie Godefroid; Willem Proesmans; Francis de Zegher; Jaak Jaeken; Chris Van Geet
GNAS defects identified by stimulatory G protein alpha-subunit signalling studies in platelets.
The Journal of clinical endocrinology and metabolism 2008;93(12):4851-9.
2008: Kathleen Freson; Benedetta Izzi; Jaak Jaeken; Maria van Helvoirt; Chantal Thys; Christine Wittevrongel; Francis de Zegher; Chris Van Geet
Compound heterozygous mutations in the GNAS gene of a boy with morbid obesity, thyroid-stimulating hormone resistance, pseudohypoparathyroidism, and a prothrombotic state.
The Journal of clinical endocrinology and metabolism 2008;93(12):4844-9.
2008: Kathleen Freson; Karen Peeters; Rita De Vos; Christine Wittevrongel; Chantal Thys; Marc F Hoylaerts; Jos Vermylen; Chris Van Geet
PACAP and its receptor VPAC1 regulate megakaryocyte maturation: therapeutic implications.
Blood 2008;111(4):1885-93.
2008: Veerle Labarque; Kathleen Freson; Chantal Thys; Christine Wittevrongel; Marc F Hoylaerts; Rita De Vos; Nathalie Goemans; Chris Van Geet
Increased Gs signalling in platelets and impaired collagen activation, due to a defect in the dystrophin gene, result in increased blood loss during spinal surgery.
Human molecular genetics 2008;17(3):357-66.
2007: Kathleen Freson; Veerle Labarque; Chantal Thys; Christine Wittevrongel; Chris Van Geet
What's new in using platelet research? To unravel thrombopathies and other human disorders.
European journal of pediatrics 2007;166(12):1203-10.
2006: Kathleen Freson; Chantal Thys; Christine Wittevrongel; Chris Van Geet
Mechanisms of action and targets for actual and future antiplatelet drugs.
Mini reviews in medicinal chemistry 2006;6(6):719-26.
2005: Kathleen Freson; Rita De Vos; Christine Wittevrongel; Chantal Thys; Johan Defoor; Luc Vanhees; Jos Vermylen; Kathelijne Peerlinck; Chris Van Geet
The TUBB1 Q43P functional polymorphism reduces the risk of cardiovascular disease in men by modulating platelet function and structure.
Blood 2005;106(7):2356-62.
2004: Kathleen Freson; Hitoshi Hashimoto; Chantal Thys; Christine Wittevrongel; Sophie Danloy; Yoshiko Morita; Norihito Shintani; Yoshiaki Tomiyama; Jos Vermylen; Marc F Hoylaerts; Akemichi Baba; Chris Van Geet
The pituitary adenylate cyclase-activating polypeptide is a physiological inhibitor of platelet activation.
The Journal of clinical investigation 2004;113(6):905-12.
2003: Kathleen Freson; Jaak Jaeken; Monique Van Helvoirt; Francis de Zegher; Christine Wittevrongel; Chantal Thys; Marc F Hoylaerts; Jos Vermylen; Chris Van Geet
Functional polymorphisms in the paternally expressed XLalphas and its cofactor ALEX decrease their mutual interaction and enhance receptor-mediated cAMP formation.
Human molecular genetics 2003;12(10):1121-30.
2003: Arnaud Bonnefoy; Hiroshi Yamamoto; Chantal Thys; Morikazu Kito; Jos Vermylen; Marc F Hoylaerts
Shielding the front-strand beta 3 of the von Willebrand factor A1 domain inhibits its binding to platelet glycoprotein Ibalpha.
Blood 2003;101(4):1375-83.
2003: Kathleen Freson; Chantal Thys; Christine Wittewrongel; Jos Vermylen; Marc F Hoylaerts; Chris Van Geet
Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions.
Human genetics 2003;112(1):42-9.
2002: Kathleen Freson; Chantal Thys; Christine Wittevrongel; Willem Proesmans; Marc F Hoylaerts; Jos Vermylen; Chris Van Geet
Pseudohypoparathyroidism type Ib with disturbed imprinting in the GNAS1 cluster and Gsalpha deficiency in platelets.
Human molecular genetics 2002;11(22):2741-50.
2002: Kathleen Freson; Gert Matthijs; Chantal Thys; Paul Mariën; Marc F Hoylaerts; Jos Vermylen; Chris Van Geet
Different substitutions at residue D218 of the X-linked transcription factor GATA1 lead to altered clinical severity of macrothrombocytopenia and anemia and are associated with variable skewed X inactivation.
Human molecular genetics 2002;11(2):147-52.
2001: Marc F Hoylaerts; A Viaene; Chantal Thys; Hans Deckmyn; Jos Vermylen
Anti-vWf antibodies induce GPIbalpha and FcgammaRII mediated platelet aggregation only at low shear forces.
Journal of thrombosis and thrombolysis 2001;12(3):249-62.
2001: Cécile Oury; Emese Toth-Zsamboki; Chantal Thys; J Tytgat; Jos Vermylen; Marc F Hoylaerts
The ATP-gated P2X1 ion channel acts as a positive regulator of platelet responses to collagen.
Thrombosis and haemostasis 2001;86(5):1264-71.
2001: Kathleen Freson; koenraad devriendt; Gert Matthijs; Achiel Van Hoof; Rita De Vos; Chantal Thys; K Minner; Marc F Hoylaerts; Jos Vermylen; Chris Van Geet
Platelet characteristics in patients with X-linked macrothrombocytopenia because of a novel GATA1 mutation.
Blood 2001;98(1):85-92.
2000: Cécile Oury; Emese Toth-Zsamboki; Chris Van Geet; Chantal Thys; L Wei; Bernd Nilius; Jos Vermylen; Marc F Hoylaerts
A natural dominant negative P2X1 receptor due to deletion of a single amino acid residue.
The Journal of biological chemistry 2000;275(30):22611-4.
1998: Marc F Hoylaerts; Chantal Thys; Jef Arnout; Jos Vermylen
Recurrent arterial thrombosis linked to autoimmune antibodies enhancing von Willebrand factor binding to platelets and inducing Fc gamma RII receptor-mediated platelet activation.
Blood 1998;91(8):2810-7.