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Tony Tiganis

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Bree J Buszard; Travis K Johnson; Tzu-Ching Meng; Richard Burke; Coral G Warr; Tony Tiganis
The nucleus- and endoplasmic reticulum-targeted forms of protein tyrosine phosphatase 61F regulate Drosophila growth, life span, and fecundity.
Benjamin J Shields; Robert L Sutherland; Kenneth Wee; Florian Wiede; Hong-Jian Zhu; Roger J Daly; Esteban N Gurzov; Christine Hauser; Catriona A McLean; Christina A Mitchell; Timothy J Molloy; Sandra A O'Toole; Tony Tiganis
TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers.
Tony Tiganis
PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis.

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All Publications

2013: Bree J Buszard; Travis K Johnson; Tzu-Ching Meng; Richard Burke; Coral G Warr; Tony Tiganis
The nucleus- and endoplasmic reticulum-targeted forms of protein tyrosine phosphatase 61F regulate Drosophila growth, life span, and fecundity.
Molecular and cellular biology 2013;33(7):1345-56.
2013: Benjamin J Shields; Robert L Sutherland; Kenneth Wee; Florian Wiede; Hong-Jian Zhu; Roger J Daly; Esteban N Gurzov; Christine Hauser; Catriona A McLean; Christina A Mitchell; Timothy J Molloy; Sandra A O'Toole; Tony Tiganis
TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers.
Molecular and cellular biology 2013;33(3):557-70.
2013: Tony Tiganis
PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis.
The FEBS journal 2013;280(2):445-58.
2012: Joanne Pagnon; Romana Stark; Tony Tiganis; Wendy Brown; S Lance Macaulay; Maria Matzaris; Ruth C R Meex; Paul E O'Brien; Matthew J Watt
Identification and functional characterization of protein kinase A phosphorylation sites in the major lipolytic protein, adipose triglyceride lipase.
Endocrinology 2012;153(9):4278-89.
2012: Sherley Visinoni; Jon Whitehead; Mildred Yim; Sofianos Andrikopoulos; Jenny M Favaloro; Christos N Joannides; Nurul Fathiah Izzati Khalid; Benjamin J Lamont; Joseph Proietto; Arthur Shulkes; Tony Tiganis; Barbara C Fam
The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity.
Diabetes 2012;61(5):1122-32.
2012: Florian Wiede; Michel L Tremblay; Catherine van Vliet; Sock Hui Chew; Dale I Godfrey; Konstantinos Kyparissoudis; Kim Loh; Ingrid J Poulton; Tedjo Sasmono; Natalie A Sims; Tony Tiganis
Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice.
PloS one 2012;7(5):e36703.
2011: Florian Wiede; Michel L Tremblay; Catherine van Vliet; Sock Hui Chew; Sandra Galic; Dale I Godfrey; Konstantinos Kyparissoudis; Sarah M Russell; Benjamin J Shields; Tony Tiganis
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice.
The Journal of clinical investigation 2011;121(12):4758-74.
2011: Kim Loh; Benjamin G Neel; Alexander Reichenbach; Stephanie Simonds; Natalie A Sims; Florian Wiede; Sheng Zhang; Xinmei Zhang; Zhong-Yin Zhang; Zane B Andrews; Kendra K Bence; Dana Briggs; Michael Alexander cowley; Pablo J Enriori; Atsushi Fukushima; Sandra Galic; Christine Hauser; Barbara B Kahn; Tony Tiganis
Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance.
Cell metabolism 2011;14(5):684-99.
2011: Chia-Lun Wu; Bree Buszard; Wei-Lin Chen; Chun-Hung Teng; Tony Tiganis; Coral G Warr; Tzu-Ching Meng
Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling.
The Biochemical journal 2011;439(1):151-9.
2011: Parvin Rahman; David A Sheffield; Absorn Sriratana; Hidetoshi Takada; Tony Tiganis; Fenny Wiradjaja; Jennifer M Dyson; Rajendra Gurung; Richard D Huysmans; Meredith J Layton; Lisa M Ooms; Christina A Mitchell
Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton.
The Journal of biological chemistry 2011;286(34):29758-70.
2011: Ahmed Bettaieb; Siming Liu; Yannan Xi; Naoto Nagata; Kosuke Matsuo; Izumi Matsuo; Samah Chahed; Jesse Bakke; Heike Keilhack; Tony Tiganis; Fawaz G Haj
Differential regulation of endoplasmic reticulum stress by protein tyrosine phosphatase 1B and T cell protein tyrosine phosphatase.
The Journal of biological chemistry 2011;286(11):9225-35.
2011: Tony Tiganis
Reactive oxygen species and insulin resistance: the good, the bad and the ugly.
Trends in pharmacological sciences 2011;32(2):82-9.
2010: Clare G Fedele; Lisa M Ooms; Miriel Ho; Jessica Vieusseux; Sandra Alison O'Toole; Ewan K Millar; Elena Lopez-Knowles; Absorn Sriratana; Rajendra Gurung; Laura Baglietto; Graham G Giles; Charles G Bailey; John Rasko; Benjamin J Shields; John T Price; Philip W Majerus; Robert L Sutherland; Tony Tiganis; Catriona A McLean; Christina A Mitchell
Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(51):22231-6.
2010: Siew Siew Pang; Richard Berry; Zhenjun Chen; Lars Kjer-Nielsen; Matthew A Perugini; Glenn F King; Christina Wang; Sock Hui Chew; Nicole L La Gruta; Neal K Williams; Travis Beddoe; Tony Tiganis; Nathan P Cowieson; Dale I Godfrey; Anthony W Purcell; Matthew C J Wilce; James McCluskey; Jamie Rossjohn
The structural basis for autonomous dimerization of the pre-T-cell antigen receptor.
Nature 2010;467(7317):844-8.
2010: Atsushi Fukushima; Kim Loh; Sandra Galic; Barbara Fam; Ben Shields; Florian Wiede; Michel L Tremblay; Matthew J Watt; Sofianos Andrikopoulos; Tony Tiganis
T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis.
Diabetes 2010;59(8):1906-14.
2010: Stephen Wong; Kheng Tan; Kirstyn T Carey; Atsushi Fukushima; Tony Tiganis; Timothy J Cole
Glucocorticoids stimulate hepatic and renal catecholamine inactivation by direct rapid induction of the dopamine sulfotransferase Sult1d1.
Endocrinology 2010;151(1):185-94.
2009: Kim Loh; Haiyang Deng; Atsushi Fukushima; Xiaochu Cai; Benoit Boivin; Sandra Galic; Clinton Bruce; Benjamin J Shields; Beata Skiba; Lisa M Ooms; Nigel Stepto; Ben Wu; Christina A Mitchell; Nicholas K Tonks; Matthew J Watt; Mark A Febbraio; Peter J Crack; Sofianos Andrikopoulos; Tony Tiganis
Reactive oxygen species enhance insulin sensitivity.
Cell metabolism 2009;10(4):260-72.
2009: Travis Beddoe; Zhenjun Chen; Craig S Clements; Lauren K Ely; Simon R Bushell; Julian P Vivian; Lars Kjer-Nielsen; Siew Siew Pang; Michelle A Dunstone; Yu Chih Liu; Whitney A Macdonald; Matthew A Perugini; Matthew C J Wilce; Scott R Burrows; Anthony W Purcell; Tony Tiganis; Stephen P Bottomley; James McCluskey; Jamie Rossjohn
Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.
Immunity 2009;30(6):777-88.
2009: Ivan Ivetac; Rajendra Gurung; Sandra Hakim; Kristy A Horan; David A Sheffield; Lauren C Binge; Philip W Majerus; Tony Tiganis; Christina A Mitchell
Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1.
EMBO reports 2009;10(5):487-93.
2009: Ben J Shields; Tony Tiganis
Replication checkpoint control by a PTK/STAT3/cyclin D1 axis.
Cell cycle (Georgetown, Tex.) 2009;8(2):223-30.
2008: Xiaoqing Lu; Raquel Malumbres; Benjamin Shields; Xiaoyu Jiang; Kristopher A Sarosiek; Yasodha Natkunam; Tony Tiganis; Izidore S Lossos
PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling.
Blood 2008;112(10):4098-108.
2008: Ben J Shields; Christine Hauser; Patricia E Bukczynska; Naomi W Court; Tony Tiganis
DNA replication stalling attenuates tyrosine kinase signaling to suppress S phase progression.
Cancer cell 2008;14(2):166-79.
2007: Xiaoqing Lu; Jun Chen; R Tedjo Sasmono; Eric D Hsi; Kristopher A Sarosiek; Tony Tiganis; Izidore S Lossos
T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6.
Molecular and cellular biology 2007;27(6):2166-79.
2007: Tony Tiganis; Anton M Bennett
Protein tyrosine phosphatase function: the substrate perspective.
The Biochemical journal 2007;402(1):1-15.
2005: Michelle T Fodero-Tavoletti; Matthew P Hardy; Brent Cornell; Frosa Katsis; Christine Sadek; Christina A Mitchell; Bruce E Kemp; Tony Tiganis
Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin polymerization.
The Biochemical journal 2005;389(Pt 2):343-54.
2005: Ivan Ivetac; Adam D Munday; Marina V Kisseleva; Xiang-Ming Zhang; Susan Luff; Tony Tiganis; James C Whisstock; Tony Rowe; Philip W Majerus; Christina A Mitchell
The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane.
Molecular biology of the cell 2005;16(5):2218-33.
2005: Catherine van Vliet; Patricia Bukczynska; Michelle A Puryer; Christine Sadek; Benjamin J Shields; Michel L Tremblay; Tony Tiganis
Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase.
Nature immunology 2005;6(3):253-60.
2005: Sandra Galic; Christine Hauser; Barbara B Kahn; Fawaz G Haj; Benjamin G Neel; Nicholas K Tonks; Tony Tiganis
Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP.
Molecular and cellular biology 2005;25(2):819-29.
2004: Takatsune Shimizu; Yoshitaka Miyakawa; Satoshi Iwata; Akiko Kuribara; Tony Tiganis; Chikao Morimoto; Yasuo Ikeda; Masahiro Kizaki
A novel mechanism for imatinib mesylate (STI571) resistance in CML cell line KT-1: role of TC-PTP in modulating signals downstream from the BCR-ABL fusion protein.
Experimental hematology 2004;32(11):1057-63.
2004: Tzu-Ching Meng; Deirdre Buckley; Sandra Galic; Tony Tiganis; Nicholas K Tonks
Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B.
The Journal of biological chemistry 2004;279(36):37716-25.
2004: Patricia Bukczynska; Manuela Klingler-Hoffmann; Kenneth I Mitchelhill; Mark H C Lam; Melissa Ciccomancini; Nicholas K Tonks; Boris Sarcevic; Bruce E Kemp; Tony Tiganis
The T-cell protein tyrosine phosphatase is phosphorylated on Ser-304 by cyclin-dependent protein kinases in mitosis.
The Biochemical journal 2004;380(Pt 3):939-49.
2003: Manuela Klingler-Hoffmann; Patricia Bukczynska; Tony Tiganis
Inhibition of phosphatidylinositol 3-kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma cells.
International journal of cancer. Journal international du cancer 2003;105(3):331-9.
2003: Sandra Galic; Manuela Klingler-Hoffmann; Michelle T Fodero-Tavoletti; Michelle A Puryer; Tzu-Ching Meng; Nicholas K Tonks; Tony Tiganis
Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP.
Molecular and cellular biology 2003;23(6):2096-108.
2002: Tony Tiganis
Protein tyrosine phosphatases: dephosphorylating the epidermal growth factor receptor.
IUBMB life 2002;53(1):3-14.
2001: Manuela Klingler-Hoffmann; Michelle T Fodero-Tavoletti; K Mishima; Y Narita; W K Cavenee; F B Furnari; Helen J Huang; Tony Tiganis
The protein tyrosine phosphatase TCPTP suppresses the tumorigenicity of glioblastoma cells expressing a mutant epidermal growth factor receptor.
The Journal of biological chemistry 2001;276(49):46313-8.
2001: Mark H C Lam; Belinda J Michell; Michelle T Fodero-Tavoletti; Bruce E Kemp; Nicholas K Tonks; Tony Tiganis
Cellular stress regulates the nucleocytoplasmic distribution of the protein-tyrosine phosphatase TCPTP.
The Journal of biological chemistry 2001;276(40):37700-7.
2001: Belinda J Michell; Tony Tiganis; David Stapleton; Frosa Katsis; David A Power; A T Sim; Bruce E Kemp
Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase.
The Journal of biological chemistry 2001;276(21):17625-8.
1999: Jörg Heierhorst; Kenneth I Mitchelhill; RJ Mann; Tony Tiganis; A J Czernik; Paul Greengard; Bruce E Kemp
Synapsins as major neuronal Ca2+/S100A1-interacting proteins.
The Biochemical journal 1999;344 Pt 2():577-83.
1999: Tony Tiganis; Bruce E Kemp; Nicholas K Tonks
The protein-tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and phosphatidylinositol 3-kinase-dependent signaling.
The Journal of biological chemistry 1999;274(39):27768-75.
1999: Belinda J Michell; J E Griffiths; Kenneth I Mitchelhill; I Rodriguez-Crespo; Tony Tiganis; Steven Bozinovski; P R de Montellano; Bruce E Kemp; Richard B Pearson
The Akt kinase signals directly to endothelial nitric oxide synthase.
Current biology : CB 1999;9(15):845-8.
1999: Mark H C Lam; CM House; Tony Tiganis; Kenneth I Mitchelhill; Boris Sarcevic; A Cures; R Ramsay; Bruce E Kemp; T John Martin; Matthew T Gillespie
Phosphorylation at the cyclin-dependent kinases site (Thr85) of parathyroid hormone-related protein negatively regulates its nuclear localization.
The Journal of biological chemistry 1999;274(26):18559-66.
1999: Trazel Teh; Tony Tiganis; Bostjan Kobe
Crystallization of importin alpha, the nuclear-import receptor.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 2):561-3.
1998: Tony Tiganis; A M Bennett; Kodi S Ravichandran; Nicholas K Tonks
Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase.
Molecular and cellular biology 1998;18(3):1622-34.
1997: L Hao; Tony Tiganis; Nicholas K Tonks; Harry Charbonneau
The noncatalytic C-terminal segment of the T cell protein tyrosine phosphatase regulates activity via an intramolecular mechanism.
The Journal of biological chemistry 1997;272(46):29322-9.
1997: Tony Tiganis; AJ Flint; Stephen Adam; Nicholas K Tonks
Association of the T-cell protein tyrosine phosphatase with nuclear import factor p97.
The Journal of biological chemistry 1997;272(34):21548-57.
1997: Bostjan Kobe; Ian G Jennings; CM House; Susanne C Feil; Belinda J Michell; Tony Tiganis; Michael W Parker; Richard G H Cotton; Bruce E Kemp
Regulation and crystallization of phosphorylated and dephosphorylated forms of truncated dimeric phenylalanine hydroxylase.
Protein science : a publication of the Protein Society 1997;6(6):1352-7.
1997: AJ Flint; Tony Tiganis; David Barford; Nicholas K Tonks
Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1680-5.
1996: Tony Tiganis; CM House; B E Kemp
Protein kinase CK2: biphasic kinetics with peptide substrates.
Archives of biochemistry and biophysics 1996;325(2):289-94.
1995: Tony Tiganis; CM House; Trazel Teh; B E Kemp
Insert regions in domain X of the casein kinase II catalytic subunit.
European journal of biochemistry / FEBS 1995;229(3):703-9.
1994: B E Kemp; Michael W Parker; S Hu; Tony Tiganis; CM House
Substrate and pseudosubstrate interactions with protein kinases: determinants of specificity.
Trends in biochemical sciences 1994;19(11):440-4.
1993: Tony Tiganis; CM House; B E Kemp
Casein kinase II beta-subunit inhibits the activity of the catalytic alpha-subunit in the absence of salt.
Biochimica et biophysica acta 1993;1203(2):282-9.