Orna Tighe

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Lieve Desbonnet; Colm O'Tuathaigh; Gerard Clarke; Claire O'Leary; Emilie Petit; Niamh Clarke; Orna Tighe; Donna Lai; Richard Harvey; John F Cryan; et al.
Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene × environment interaction.
Lieve Desbonnet; Orna Tighe; Maria Karayiorgou; Joseph A Gogos; John L Waddington; Colm M P O'Tuathaigh
Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice.
Colm M P O'Tuathaigh; Magdalena Hryniewiecka; Aine Behan; Orna Tighe; Catherine Coughlan; Lieve Desbonnet; Mary Cannon; Maria Karayiorgou; Joseph A Gogos; David R Cotter; et al.
Chronic adolescent exposure to Δ-9-tetrahydrocannabinol in COMT mutant mice: impact on psychosis-related and other phenotypes.

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All Publications

2012: Lieve Desbonnet; Colm O'Tuathaigh; Gerard Clarke; Claire O'Leary; Emilie Petit; Niamh Clarke; Orna Tighe; Donna Lai; Richard Harvey; John F Cryan; et al.
Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene × environment interaction.
Brain, behavior, and immunity 2012;26(4):660-71.
2012: Lieve Desbonnet; Orna Tighe; Maria Karayiorgou; Joseph A Gogos; John L Waddington; Colm M P O'Tuathaigh
Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice.
Behavioural brain research 2012;228(2):351-8.
2010: Colm M P O'Tuathaigh; Magdalena Hryniewiecka; Aine Behan; Orna Tighe; Catherine Coughlan; Lieve Desbonnet; Mary Cannon; Maria Karayiorgou; Joseph A Gogos; David R Cotter; et al.
Chronic adolescent exposure to Δ-9-tetrahydrocannabinol in COMT mutant mice: impact on psychosis-related and other phenotypes.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010;35(11):2262-73.
2010: J Walsh; O Tighe; D Lai; R Harvey; M Karayiorgou; J A Gogos; J L Waddington; C M P O'Tuathaigh
Disruption of thermal nociceptive behaviour in mice mutant for the schizophrenia-associated genes NRG1, COMT and DISC1.
Brain research 2010;1348():114-9.
2010: Ciara Vangjeli; Niamh Clarke; Ursula Quinn; Patrick Dicker; Orna Tighe; Clara Ho; Eoin O'Brien; Alice V Stanton
Confirmation that the renin gene distal enhancer polymorphism REN-5312C/T is associated with increased blood pressure.
Circulation. Cardiovascular genetics 2010;3(1):53-9.
2010: J M Flanagan; G McMahon; S H Brendan Chia; P Fitzpatrick; O Tighe; C O'Neill; P Briones; L Gort; L Kozak; A Magee; et al.
The role of human demographic history in determining the distribution and frequency of transferase-deficient galactosaemia mutations.
Heredity 2010;104(2):148-54.
2010: C M P O'Tuathaigh; M Harte; C O'Leary; G J O'Sullivan; C Blau; D Lai; R P Harvey; O Tighe; A J Fagan; C Kerskens; et al.
Schizophrenia-related endophenotypes in heterozygous neuregulin-1 'knockout' mice.
The European journal of neuroscience 2010;31(2):349-58.
2007: Daniela Babovic; Colm M O'Tuathaigh; Gerard J O'Sullivan; Jeremiah J Clifford; Orna Tighe; David T Croke; Maria Karayiorgou; Joseph A Gogos; David Cotter; John L Waddington
Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice.
Behavioural brain research 2007;183(2):236-9.
2007: C M P O'Tuathaigh; D Babovic; G J O'Sullivan; J J Clifford; O Tighe; D T Croke; R Harvey; J L Waddington
Phenotypic characterization of spatial cognition and social behavior in mice with 'knockout' of the schizophrenia risk gene neuregulin 1.
Neuroscience 2007;147(1):18-27.
2006: Katsunori Tomiyama; Yasuyuki Makihara; Hiroshi Yamamoto; Gerard O'Sullivan; Rachel E Nally; Orna Tighe; Anthony Kinsella; Allen A Fienberg; David K Grandy; David R Sibley; et al.
Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction 'knockout'.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2006;16(6):437-45.
2006: Gerard J O'Sullivan; Anthony Kinsella; David K Grandy; Orna Tighe; David T Croke; John L Waddington
Ethological resolution of behavioral topography and D2-like vs. D1-like agonist responses in congenic D4 dopamine receptor "knockouts": identification of D4:D1-like interactions.
Synapse (New York, N.Y.) 2006;59(2):107-18.
2006: Colm M O'Tuathaigh; Gerard J O'Sullivan; Anthony Kinsella; Richard P Harvey; Orna Tighe; David T Croke; John L Waddington
Sexually dimorphic changes in the exploratory and habituation profiles of heterozygous neuregulin-1 knockout mice.
Neuroreport 2006;17(1):79-83.
2005: Gerard J O'Sullivan; Anthony Kinsella; David R Sibley; Orna Tighe; David T Croke; John L Waddington
Ethological resolution of behavioural topography and D1-like versus D2-like agonist responses in congenic D5 dopamine receptor mutants: identification of D5:D2-like interactions.
Synapse (New York, N.Y.) 2005;55(4):201-11.
2004: Rachel E Nally; Anthony Kinsella; Orna Tighe; David T Croke; Allen A Fienberg; Paul Greengard; John L Waddington
Ethologically based resolution of D2-like dopamine receptor agonist-versus antagonist-induced behavioral topography in dopamine- and adenosine 3',5'-monophosphate-regulated phosphoprotein of 32 kDa "knockout" mutants congenic on the C57BL/6 genetic background.
The Journal of pharmacology and experimental therapeutics 2004;310(3):1281-7.
2004: Orna Tighe; Jonathon M Flanagan; Fiona Kernan; Charles O'Neill; Eileen Naughten; Philip D Mayne; David T Croke
Frequency distribution of the Los Angeles and Duarte galactose-1-phosphate uridyltransferase variant alleles in the Irish population.
Molecular genetics and metabolism 2004;82(4):345-7.
2004: Jonathon M Flanagan; Orna Tighe; Charles O' Neill; Eileen Naughten; Philip D Mayne; David T Croke
Identification of sequence variation in the galactose-1-phosphate uridyl transferase gene by dHPLC.
Molecular genetics and metabolism 2004;81(2):133-6.
2004: Katsunori Tomiyama; Fergal N McNamara; Jeremiah J Clifford; Anthony Kinsella; John Drago; Sara Fuchs; David K Grandy; Malcolm J Low; Marcelo Rubinstein; Orna Tighe; et al.
Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout".
Synapse (New York, N.Y.) 2004;51(1):71-81.
2003: Rachel E Nally; Fergal N McNamara; Jeremiah J Clifford; A Kinsella; Orna Tighe; David T Croke; Allen A Fienberg; Paul Greengard; John L Waddington
Topographical Assessment of Ethological and Dopamine Receptor Agonist-Induced Behavioral Phenotype in Mutants with Congenic DARPP-32 'Knockout'.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(12):2055-63.
2003: Orna Tighe; Donncha Dunican; Charles O'Neill; Giorgio Bertorelle; Diane Beattie; Colin Graham; Johannes Zschocke; Francesco Cali; Valentino Romano; Eva Hrabincova; et al.
Genetic diversity within the R408W phenylketonuria mutation lineages in Europe.
Human mutation 2003;21(4):387-93.
2003: Fergal N McNamara; Jeremiah J Clifford; Orna Tighe; Anthony Kinsella; John Drago; David T Croke; John L Waddington
Congenic D1A dopamine receptor mutants: ethologically based resolution of behavioural topography indicates genetic background as a determinant of knockout phenotype.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(1):86-99.
2002: Fergal N McNamara; Jeremiah J Clifford; Orna Tighe; Anthony Kinsella; John Drago; Sara Fuchs; David T Croke; John L Waddington
Phenotypic, ethologically based resolution of spontaneous and D(2)-like vs D(1)-like agonist-induced behavioural topography in mice with congenic D(3) dopamine receptor "knockout".
Synapse (New York, N.Y.) 2002;46(1):19-31.
2002: Kate A O'Donnell; Charles O'Neill; Orna Tighe; Giorgio Bertorelle; Eileen Naughten; Philip D Mayne; David T Croke
The mutation spectrum of hyperphenylalaninaemia in the Republic of Ireland: the population history of the Irish revisited.
European journal of human genetics : EJHG 2002;10(9):530-8.
2002: Donncha S Dunican; Peter McWilliam; Orna Tighe; Anne Parle-McDermott; David T Croke
Gene expression differences between the microsatellite instability (MIN) and chromosomal instability (CIN) phenotypes in colorectal cancer revealed by high-density cDNA array hybridization.
Oncogene 2002;21(20):3253-7.
2002: K Tomiyama; F N McNamara; J J Clifford; A Kinsella; J Drago; O Tighe; D T Croke; N Koshikawa; J L Waddington
Phenotypic resolution of spontaneous and D1-like agonist-induced orofacial movement topographies in congenic dopamine D1A receptor 'knockout' mice.
Neuropharmacology 2002;42(5):644-52.
2001: J J Clifford; A Kinsella; O Tighe; M Rubinstein; D K Grandy; M J Low; D T Croke; J L Waddington
Comparative, topographically-based evaluation of behavioural phenotype and specification of D(1)-like:D(2) interactions in a line of incipient congenic mice with D(2) dopamine receptor 'knockout'.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001;25(4):527-36.
2001: K A O'Donnell; O Tighe; C O'Neill; E Naughten; P D Mayne; T V McCarthy; P Vaughan; D T Croke
Rapid detection of the R408W and I65T mutations in phenylketonuria by glycosylase mediated polymorphism detection.
Human mutation 2001;17(5):432.
2000: A Parle-McDermott; P McWilliam; O Tighe; D Dunican; D T Croke
Serial analysis of gene expression identifies putative metastasis-associated transcripts in colon tumour cell lines.
British journal of cancer 2000;83(6):725-8.
2000: B Curran; K Lenehan; H Mulcahy; O Tighe; M A Bennett; E W Kay; D P O'Donoghue; M Leader; D T Croke
Replication error phenotype, clinicopathological variables, and patient outcome in Dukes' B stage II (T3,N0,M0) colorectal cancer.
Gut 2000;46(2):200-4.
1999: M Murphy; B McHugh; O Tighe; P Mayne; C O'Neill; E Naughten; D T Croke
Genetic basis of transferase-deficient galactosaemia in Ireland and the population history of the Irish Travellers.
European journal of human genetics : EJHG 1999;7(5):549-54.
1999: J J Clifford; O Tighe; D T Croke; A Kinsella; D R Sibley; J Drago; J L Waddington
Conservation of behavioural topography to dopamine D1-like receptor agonists in mutant mice lacking the D1A receptor implicates a D1-like receptor not coupled to adenylyl cyclase.
Neuroscience 1999;93(4):1483-9.
1998: J J Clifford; O Tighe; D T Croke; D R Sibley; J Drago; J L Waddington
Topographical evaluation of the phenotype of spontaneous behaviour in mice with targeted gene deletion of the D1A dopamine receptor: paradoxical elevation of grooming syntax.
Neuropharmacology 1998;37(12):1595-602.
1998: D Dunican; O Tighe; A Parle-McDermott; D T Croke
Studies of gene expression patterns in RER+ and RER- colon cancer cell lines.
Biochemical Society transactions 1998;26(3):S266.
1998: O Tighe; M Carmody; D T Croke
Identification of a novel PKD1 mutation in an Irish autosomal dominant polycystic kidney disease kindred.
Biochemical Society transactions 1998;26(3):S265.
1998: J L Waddington; A M Deveney; J Clifford; O Tighe; D T Croke; D R Sibley; J Drago
Behavioral analysis of multiple D1-like dopamine receptor subtypes: new agents and studies in transgenic mice with D1A receptor knockout.
Advances in pharmacology (San Diego, Calif.) 1998;42():514-7.
1995: O Tighe; M Carmody; D T Croke
Molecular genetic analysis of ADPKD in Irish families.
Contributions to nephrology 1995;115():102-4.
1991: D Owens; P Collins; A Johnson; O Tighe; K Robinson; G H Tomkin
Hypercholesterolaemia: simvastatin and pravastatin alter cholesterol metabolism by different mechanisms.
Biochimica et biophysica acta 1991;1082(3):303-9.
1990: J A Kelly; K Robinson; O P Tighe; B Dickson; G H Tomkin; P B Collins; A H Johnson
Combined familial hyperlipidaemia in association with apolipoprotein E3 phenotype.
Biochemical Society transactions 1990;18(4):631.