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Laura Borsi

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Paola Orecchia; Luciano Zardi; Enrica Balza; Laura Borsi; Patrizia Castellani; Romana Conte; Maria Cristina Mingari; Barbara Carnemolla
Identification of a novel cell binding site of periostin involved in tumour growth.
Elisa Ventura; Enrica Balza; Laura Borsi; Barbara Carnemolla; Patrizia Castellani; Giorgia Tutolo; Luciano Zardi
Selective targeted delivery of the TNF-alpha receptor p75 and uteroglobin to the vasculature of inflamed tissues: a preliminary report.
Elisa Ventura; Francesca Sassi; Arianna Parodi; Enrica Balza; Laura Borsi; Patrizia Castellani; Barbara Carnemolla; Luciano Zardi
Alternative splicing of the angiogenesis associated extra-domain B of fibronectin regulates the accessibility of the B-C loop of the type III repeat 8.

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All Publications

2011: Paola Orecchia; Luciano Zardi; Enrica Balza; Laura Borsi; Patrizia Castellani; Romana Conte; Maria Cristina Mingari; Barbara Carnemolla
Identification of a novel cell binding site of periostin involved in tumour growth.
European journal of cancer (Oxford, England : 1990) 2011;47(14):2221-9.
2011: Elisa Ventura; Enrica Balza; Laura Borsi; Barbara Carnemolla; Patrizia Castellani; Giorgia Tutolo; Luciano Zardi
Selective targeted delivery of the TNF-alpha receptor p75 and uteroglobin to the vasculature of inflamed tissues: a preliminary report.
BMC biotechnology 2011;11():104.
2010: Elisa Ventura; Francesca Sassi; Arianna Parodi; Enrica Balza; Laura Borsi; Patrizia Castellani; Barbara Carnemolla; Luciano Zardi
Alternative splicing of the angiogenesis associated extra-domain B of fibronectin regulates the accessibility of the B-C loop of the type III repeat 8.
PloS one 2010;5(2):e9145.
2009: Elisa Ventura; Francesca Sassi; Sara Fossati; Arianna Parodi; William Blalock; Enrica Balza; Patrizia Castellani; Laura Borsi; Barbara Carnemolla; Luciano Zardi
Use of uteroglobin for the engineering of polyvalent, polyspecific fusion proteins.
The Journal of biological chemistry 2009;284(39):26646-54.
2009: Enrica Balza; Francesca Sassi; Elisa Ventura; Arianna Parodi; Sara Fossati; William Blalock; Barbara Carnemolla; Patrizia Castellani; Luciano Zardi; Laura Borsi
A novel human fibronectin cryptic sequence unmasked by the insertion of the angiogenesis-associated extra type III domain B.
International journal of cancer. Journal international du cancer 2009;125(4):751-8.
2009: Angela Berndt; Jens Müller; Laura Borsi; Hartwig Kosmehl; Ulrich Methner; Alexander Berndt
Reorganisation of the caecal extracellular matrix upon Salmonella infection--relation between bacterial invasiveness and expression of virulence genes.
Veterinary microbiology 2009;133(1-2):123-37.
2008: Carola Leipner; Katja Grün; Andreas Müller; Elisabeth Buchdunger; Laura Borsi; Hartwig Kosmehl; Alexander Berndt; Tobias Janik; Andrea Uecker; Michael Kiehntopf; Frank-D Böhmer
Imatinib mesylate attenuates fibrosis in coxsackievirus b3-induced chronic myocarditis.
Cardiovascular research 2008;79(1):118-26.
2008: Alessandra Villa; Eveline Trachsel; Manuela Kaspar; Christoph Schliemann; Roberto Sommavilla; Jascha-N Rybak; Christoph Roesli; Laura Borsi; Dario Neri
A high-affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently targets tumor neo-vasculature in vivo.
International journal of cancer. Journal international du cancer 2008;122(11):2405-13.
2007: Lorenzo Mortara; Enrica Balza; Francesca Sassi; Patrizia Castellani; Barbara Carnemolla; Andrea De Lerma Barbaro; Sara Fossati; Giovanna Tosi; Roberto Accolla; Laura Borsi
Therapy-induced antitumor vaccination by targeting tumor necrosis factor alpha to tumor vessels in combination with melphalan.
European journal of immunology 2007;37(12):3381-92.
2007: Marcus Franz; Torsten Hansen; Laura Borsi; Christiane Geier; Peter Hyckel; Peter Schleier; Petra Richter; Annelore Altendorf-Hofmann; Hartwig Kosmehl; Alexander Berndt
A quantitative co-localization analysis of large unspliced tenascin-C(L) and laminin-5/gamma2-chain in basement membranes of oral squamous cell carcinoma by confocal laser scanning microscopy.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2007;36(1):6-11.
2006: Alexander Berndt; Katharina Anger; Petra Richter; Laura Borsi; Simon S Brack; Michela Silacci; Marcus Franz; Heiko Wunderlich; Mieczyslaw Gajda; Luciano Zardi; Dario Neri; Hartwig Kosmehl
Differential expression of tenascin-C splicing domains in urothelial carcinomas of the urinary bladder.
Journal of cancer research and clinical oncology 2006;132(8):537-46.
2006: Marcus Franz; Torsten Hansen; Petra Richter; Laura Borsi; Frank-D Böhmer; Peter Hyckel; Peter Schleier; Detlef Katenkamp; Luciano Zardi; Hartwig Kosmehl; Alexander Berndt
Complex formation of the laminin-5 gamma2 chain and large unspliced tenascin-C in oral squamous cell carcinoma in vitro and in situ: implications for sequential modulation of extracellular matrix in the invasive tumor front.
Histochemistry and cell biology 2006;126(1):125-31.
2006: Enrica Balza; Lorenzo Mortara; Francesca Sassi; Stefano Monteghirfo; Barbara Carnemolla; Patrizia Castellani; Dario Neri; Roberto Accolla; Luciano Zardi; Laura Borsi
Targeted delivery of tumor necrosis factor-alpha to tumor vessels induces a therapeutic T cell-mediated immune response that protects the host against syngeneic tumors of different histologic origin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(8):2575-82.
2005: Petra Richter; Frank-D Böhmer; Winfried Hindermann; Laura Borsi; Peter Hyckel; Peter Schleier; Detlef Katenkamp; Hartwig Kosmehl; Alexander Berndt
Analysis of activated EGFR signalling pathways and their relation to laminin-5 gamma2 chain expression in oral squamous cell carcinoma (OSCC).
Histochemistry and cell biology 2005;124(2):151-60.
2005: Martin Köbel; Daniel Budianto; Wolfgang Schmitt; Laura Borsi; Annalisa Siri; Steffen Hauptmann
Influence of various cytokines on adhesion and migration of the colorectal adenocarcinoma cell line HRT-18.
Oncology 2005;68(1):33-9.
2004: Kathrin Katenkamp; Alexander Berndt; Winfried Hindermann; Heiko Wunderlich; Karl Michael Haas; Laura Borsi; Luciano Zardi; Hartwig Kosmehl
mRNA expression and protein distribution of the unspliced tenascin-C isoform in prostatic adenocarcinoma.
The Journal of pathology 2004;203(3):771-9.
2004: Jörg Kriegsmann; A Berndt; T Hansen; Laura Borsi; L Zardi; Rolf Bräuer; Peter Petrow; M Otto; C J Kirkpatrick; Steffen GAY; H Kosmehl
Expression of fibronectin splice variants and oncofetal glycosylated fibronectin in the synovial membranes of patients with rheumatoid arthritis and osteoarthritis.
Rheumatology international 2004;24(1):25-33.
2003: Laura Borsi; Enrica Balza; Barbara Carnemolla; Francesca Sassi; Patrizia Castellani; Alexander Berndt; Hartwig Kosmehl; Attila Biro; Annalisa Siri; Paola Orecchia; Jessica Grassi; Dario Neri; Luciano Zardi
Selective targeted delivery of TNFalpha to tumor blood vessels.
Blood 2003;102(13):4384-92.
2003: Wichard Vogel; Alexander Berndt; Angelika Müller; Regine Dahse; Karl Michael Haas; Laura Borsi; Luciano Zardi; Hartwig Kosmehl
Differential in vivo and in vitro expression of ED-B+ fibronectin in adult human hematopoiesis.
International journal of molecular medicine 2003;12(6):831-7.
2003: Cornelia Halin; Verena Gafner; Maria Elena Villani; Laura Borsi; Alexander Berndt; Hartwig Kosmehl; Luciano Zardi; Dario Neri
Synergistic therapeutic effects of a tumor targeting antibody fragment, fused to interleukin 12 and to tumor necrosis factor alpha.
Cancer research 2003;63(12):3202-10.
2003: Monica Santimaria; Giovanni Moscatelli; Giuseppe L Viale; Leonardo Giovannoni; Giovanni Neri; Francesca Viti; Alessandra Leprini; Laura Borsi; Patrizia Castellani; Luciano Zardi; Dario Neri; Pietro Riva
Immunoscintigraphic detection of the ED-B domain of fibronectin, a marker of angiogenesis, in patients with cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(2):571-9.
2003: Steffen Hauptmann; Daniel Budianto; Carsten Denkert; Martin Köbel; Laura Borsi; Annalisa Siri
Adhesion and migration of HRT-18 colorectal carcinoma cells on extracellular matrix components typical for the desmoplastic stroma of colorectal adenocarcinomas.
Oncology 2003;65(2):174-81.
2003: Steffen Hauptmann; Antje Siegert; Stefan Berger; Carsten Denkert; Martin Köbel; Stefan Ott; Annalisa Siri; Laura Borsi
Regulation of cell growth and the expression of extracellular matrix proteins in colorectal adenocarcinoma: a fibroblast-tumor cell coculture model to study tumor-host interactions in vitro.
European journal of cell biology 2003;82(1):1-8.
2002: Samu Melkko; Cornelia Halin; Laura Borsi; Luciano Zardi; Dario Neri
An antibody-calmodulin fusion protein reveals a functional dependence between macromolecular isoelectric point and tumor targeting performance.
International journal of radiation oncology, biology, physics 2002;54(5):1485-90.
2002: Patrizia Castellani; Laura Borsi; Barbara Carnemolla; Attila Birò; Alessandra Dorcaratto; Giuseppe L Viale; Dario Neri; Luciano Zardi
Differentiation between high- and low-grade astrocytoma using a human recombinant antibody to the extra domain-B of fibronectin.
The American journal of pathology 2002;161(5):1695-700.
2002: Laura Borsi; Enrica Balza; Marco Bestagno; Patrizia Castellani; Barbara Carnemolla; Attila Biro; Alessandra Leprini; Jorge Sepulveda; Oscar R. Burrone; Dario Neri; Luciano Zardi
Selective targeting of tumoral vasculature: comparison of different formats of an antibody (L19) to the ED-B domain of fibronectin.
International journal of cancer. Journal international du cancer 2002;102(1):75-85.
2002: Barbara Carnemolla; Laura Borsi; Enrica Balza; Patrizia Castellani; Raffaella Meazza; Alexander Berndt; Silvano Ferrini; Hartwig Kosmehl; Dario Neri; Luciano Zardi
Enhancement of the antitumor properties of interleukin-2 by its targeted delivery to the tumor blood vessel extracellular matrix.
Blood 2002;99(5):1659-65.
2001: Laura Borsi; Barbara Carnemolla; Dario Neri; Luciano Zardi
Use of human recombinant antibodies to the marker of angiogenesis ed-b in cancer therapy.
Tumori 2001;87(6):S8-10.
2001: Alexander Berndt; Laura Borsi; Peter Hyckel; Hartwig Kosmehl
Fibrillary co-deposition of laminin-5 and large unspliced tenascin-C in the invasive front of oral squamous cell carcinoma in vivo and in vitro.
Journal of cancer research and clinical oncology 2001;127(5):286-92.
2001: Salvatore Demartis; L Tarli; Laura Borsi; Luciano Zardi; Dario Neri
Selective targeting of tumour neovasculature by a radiohalogenated human antibody fragment specific for the ED-B domain of fibronectin.
European journal of nuclear medicine 2001;28(4):534-9.
1999: Winfried Hindermann; Alexander Berndt; Laura Borsi; X Luo; Peter Hyckel; Detlef Katenkamp; Hartwig Kosmehl
Synthesis and protein distribution of the unspliced large tenascin-C isoform in oral squamous cell carcinoma.
The Journal of pathology 1999;189(4):475-80.
1999: Hartwig Kosmehl; Alexander Berndt; S Strassburger; Laura Borsi; P Rousselle; U Mandel; Peter Hyckel; Luciano Zardi; Detlef Katenkamp
Distribution of laminin and fibronectin isoforms in oral mucosa and oral squamous cell carcinoma.
British journal of cancer 1999;81(6):1071-9.
1999: L Tarli; Enrica Balza; Francesca Viti; Laura Borsi; Patrizia Castellani; Dietmar Berndorff; Ludger M Dinkelborg; Dario Neri; Luciano Zardi
A high-affinity human antibody that targets tumoral blood vessels.
Blood 1999;94(1):192-8.
1999: Barbara Carnemolla; Patrizia Castellani; Marco Ponassi; Laura Borsi; S Urbini; G Nicolo; Alessandra Dorcaratto; Giuseppe L Viale; G Winter; Dario Neri; Luciano Zardi
Identification of a glioblastoma-associated tenascin-C isoform by a high affinity recombinant antibody.
The American journal of pathology 1999;154(5):1345-52.
1998: G Serini; Marie-Luce Bochaton-Piallat; Patricia Ropraz; Antoine Geinoz; Laura Borsi; L Zardi; Giulio Gabbiani
The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1.
The Journal of cell biology 1998;142(3):873-81.
1998: Laura Borsi; Patrizia Castellani; G Allemanni; Dario Neri; Luciano Zardi
Preparation of phage antibodies to the ED-A domain of human fibronectin.
Experimental cell research 1998;240(2):244-51.
1998: Alexander Berndt; Laura Borsi; X Luo; Luciano Zardi; Detlef Katenkamp; Hartwig Kosmehl
Evidence of ED-B+ fibronectin synthesis in human tissues by non-radioactive RNA in situ hybridization. Investigations on carcinoma (oral squamous cell and breast carcinoma), chronic inflammation (rheumatoid synovitis) and fibromatosis (Morbus Dupuytren).
Histochemistry and cell biology 1998;109(3):249-55.
1998: Alessandra Leprini; Roberto Gherzi; E Vecchi; Laura Borsi; Luciano Zardi; Annalisa Siri
Rat tenascin-R gene: structure, chromosome location and transcriptional activity of promoter and exon 1.
Cytogenetics and cell genetics 1998;83(1-2):115-23.
1996: Laura Borsi; G Allemanni; B Gaggero; Luciano Zardi
Extracellular pH controls pre-mRNA alternative splicing of tenascin-C in normal, but not in malignantly transformed, cells.
International journal of cancer. Journal international du cancer 1996;66(5):632-5.
1996: Barbara Carnemolla; Alessandra Leprini; Laura Borsi; G Querzé; S Urbini; Luciano Zardi
Human tenascin-R. Complete primary structure, pre-mRNA alternative splicing and gene localization on chromosome 1q23-q24.
The Journal of biological chemistry 1996;271(14):8157-60.
1995: Steffen Hauptmann; L Zardi; Annalisa Siri; Barbara Carnemolla; Laura Borsi; Mario Castellucci; Bernd Klosterhalfen; P Hartung; J Weis; G Stöcker
Extracellular matrix proteins in colorectal carcinomas. Expression of tenascin and fibronectin isoforms.
Laboratory investigation; a journal of technical methods and pathology 1995;73(2):172-82.
1995: Laura Borsi; Enrica Balza; B Gaggero; G Allemanni; Luciano Zardi
The alternative splicing pattern of the tenascin-C pre-mRNA is controlled by the extracellular pH.
The Journal of biological chemistry 1995;270(11):6243-5.
1994: Laura Borsi; Enrica Balza; Patrizia Castellani; Barbara Carnemolla; Marco Ponassi; G Querzé; Luciano Zardi
Cell-cycle dependent alternative splicing of the tenascin primary transcript.
Cell adhesion and communication 1994;1(4):307-17.
1993: Laura Borsi; Barbara Carnemolla; Marco Ponassi; Luciano Zardi
Steady-state levels of different tenascin mRNAs in various normal human tissues.
Cell biology international 1993;17(3):325-9.
1992: Laura Borsi; Barbara Carnemolla; Guido Nicolò; B Spina; G Tanara; Luciano Zardi
Expression of different tenascin isoforms in normal, hyperplastic and neoplastic human breast tissues.
International journal of cancer. Journal international du cancer 1992;52(5):688-92.
1992: Barbara Carnemolla; Laura Borsi; G Bannikov; S Troyanovsky; Luciano Zardi
Comparison of human tenascin expression in normal, simian-virus-40-transformed and tumor-derived cell lines.
European journal of biochemistry / FEBS 1992;205(2):561-7.
1992: Laura Borsi; Enrica Balza; G Allemanni; Luciano Zardi
Differential expression of the fibronectin isoform containing the ED-B oncofetal domain in normal human fibroblast cell lines originating from different tissues.
Experimental cell research 1992;199(1):98-105.
1991: Laura Borsi; Enrica Balza; Alessandra Leprini; Marco Ponassi; Luciano Zardi
Procedure for the purification of the fibronectin proteolytic fragments containing the ED-B oncofetal domain.
Analytical biochemistry 1991;192(2):372-9.
1990: Guido Nicolò; S Salvi; G Oliveri; Laura Borsi; Patrizia Castellani; L Zardi
Expression of tenascin and of the ED-B containing oncofetal fibronectin isoform in human cancer.
Cell differentiation and development : the official journal of the International Society of Developmental Biologists 1990;32(3):401-8.
1990: Laura Borsi; Patrizia Castellani; A M Risso; Alessandra Leprini; Luciano Zardi
Transforming growth factor-beta regulates the splicing pattern of fibronectin messenger RNA precursor.
FEBS letters 1990;261(1):175-8.
1988: Enrica Balza; Laura Borsi; G Allemanni; Luciano Zardi
Transforming growth factor beta regulates the levels of different fibronectin isoforms in normal human cultured fibroblasts.
FEBS letters 1988;228(1):42-4.
1987: Barbara Carnemolla; Laura Borsi; L Zardi; R J Owens; F E Baralle
Localization of the cellular-fibronectin-specific epitope recognized by the monoclonal antibody IST-9 using fusion proteins expressed in E. coli.
FEBS letters 1987;215(2):269-73.
1987: Laura Borsi; Barbara Carnemolla; Patrizia Castellani; C Rosellini; D Vecchio; G Allemanni; S E Chang; J Taylor-Papadimitriou; H Pande; Luciano Zardi
Monoclonal antibodies in the analysis of fibronectin isoforms generated by alternative splicing of mRNA precursors in normal and transformed human cells.
The Journal of cell biology 1987;104(3):595-600.
1987: H Pande; J Calaycay; T D Lee; K Legesse; John E Shively; Annalisa Siri; Laura Borsi; Luciano Zardi
Demonstration of structural differences between the two subunits of human-plasma fibronectin in the carboxy-terminal heparin-binding domain.
European journal of biochemistry / FEBS 1987;162(2):403-11.
1986: Francesco Boccardo; D Guarneri; S Zanardi; Patrizia Castellani; Laura Borsi; L Zardi
Fibronectin concentration in the plasma of patients with malignant and benign breast disease.
Cancer letters 1986;33(3):317-23.
1986: Patrizia Castellani; Annalisa Siri; C Rosellini; E Infusini; Laura Borsi; Luciano Zardi
Transformed human cells release different fibronectin variants than do normal cells.
The Journal of cell biology 1986;103(5):1671-7.
1986: Laura Borsi; Patrizia Castellani; Enrica Balza; Annalisa Siri; C Pellecchia; F De Scalzi; Luciano Zardi
Large-scale procedure for the purification of fibronectin domains.
Analytical biochemistry 1986;155(2):335-45.
1986: M Cutolo; P Castellani; Laura Borsi; L Zardi
Altered fibronectin distribution in cultured fibroblasts from patients with Ehlers-Danlos syndrome.
Clinical and experimental rheumatology 1986;4(2):125-8.
1986: Annalisa Siri; Enrica Balza; Barbara Carnemolla; Patrizia Castellani; Laura Borsi; Luciano Zardi
DNA-binding domains of human plasma fibronectin. pH and calcium ion modulation of fibronectin binding to DNA and heparin.
European journal of biochemistry / FEBS 1986;154(3):533-8.
1986: C Falugi; Patrizia Castellani; S Raffanti; Laura Borsi; Luciano Zardi
Acetylcholinesterase in normal and malignant human cells.
Basic and applied histochemistry 1986;30(4):433-46.
1985: Laura Borsi; G Allemanni; Patrizia Castellani; C Rosellini; A Di Vinci; Luciano Zardi
Structural differences in the cell binding region of human fibronectin molecules isolated from cultured normal and tumor-derived human cells.
FEBS letters 1985;192(1):71-4.
1985: J Calaycay; H Pande; T Lee; Laura Borsi; Annalisa Siri; John E Shively; Luciano Zardi
Primary structure of a DNA- and heparin-binding domain (Domain III) in human plasma fibronectin.
The Journal of biological chemistry 1985;260(22):12136-41.
1985: Luciano Zardi; Barbara Carnemolla; Enrica Balza; Laura Borsi; Patrizia Castellani; M Rocco; Annalisa Siri
Elution of fibronectin proteolytic fragments from a hydroxyapatite chromatography column. A simple procedure for the purification of fibronectin domains.
European journal of biochemistry / FEBS 1985;146(3):571-9.
1984: Barbara Carnemolla; Patrizia Castellani; M Cutolo; Laura Borsi; L Zardi
Lack of sialic acid in synovial fluid fibronectin.
FEBS letters 1984;171(2):285-8.