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Denis Tikhonov

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TOP 3
Boris S Zhorov; Denis B Tikhonov
Ligand action on sodium, potassium, and calcium channels: role of permeant ions.
Denis B Tikhonov; Boris S Zhorov
Architecture and pore block of eukaryotic voltage-gated sodium channels in view of NavAb bacterial sodium channel structure.
Maxim V Nikolaev; Lev G Magazanik; Denis B Tikhonov
Influence of external magnesium ions on the NMDA receptor channel block by different types of organic cations.

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All Publications

2013: Boris S Zhorov; Denis B Tikhonov
Ligand action on sodium, potassium, and calcium channels: role of permeant ions.
Trends in pharmacological sciences 2013;34(3):154-61.
2012: Denis B Tikhonov; Boris S Zhorov
Architecture and pore block of eukaryotic voltage-gated sodium channels in view of NavAb bacterial sodium channel structure.
Molecular pharmacology 2012;82(1):97-104.
2012: Maxim V Nikolaev; Lev G Magazanik; Denis B Tikhonov
Influence of external magnesium ions on the NMDA receptor channel block by different types of organic cations.
Neuropharmacology 2012;62(5-6):2078-85.
2011: Oleg I Barygin; Eugene V Grishin; Denis B Tikhonov
Argiotoxin in the closed AMPA receptor channel: experimental and modeling study.
Biochemistry 2011;50(38):8213-20.
2011: Denis B Tikhonov; Boris S Zhorov
Possible roles of exceptionally conserved residues around the selectivity filters of sodium and calcium channels.
The Journal of biological chemistry 2011;286(4):2998-3006.
2010: Oleg I Barygin; Natalia V Luchkina; Denis B Tikhonov
Voltage-dependent and -independent block of α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor channels.
Journal of neurochemistry 2010;115(6):1621-32.
2010: SN Moralev; Denis B Tikhonov
Investigation of structure-activity relationships in organophosphates-cholinesterase interaction using docking analysis.
Chemico-biological interactions 2010;187(1-3):153-6.
2010: Ricky C K Cheng; Denis B Tikhonov; Boris S Zhorov
Structural modeling of calcium binding in the selectivity filter of the L-type calcium channel.
European biophysics journal : EBJ 2010;39(5):839-53.
2009: Ricky C K Cheng; Denis B Tikhonov; Boris S Zhorov
Structural model for phenylalkylamine binding to L-type calcium channels.
The Journal of biological chemistry 2009;284(41):28332-42.
2009: TB Tikhonova; Denis B Tikhonov; Lev G Magazanik
Common binding site for externally and internally applied AMPA receptor channel blockers.
Journal of molecular neuroscience : MN 2009;39(1-2):169-74.
2009: Denis B Tikhonov; Boris S Zhorov
Structural model for dihydropyridine binding to L-type calcium channels.
The Journal of biological chemistry 2009;284(28):19006-17.
2009: I M Fedorova; Lev G Magazanik; Denis B Tikhonov
Characterization of ionotropic glutamate receptors in insect neuro-muscular junction.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2009;149(3):275-80.
2009: Oleg I Barygin; VE Gmiro; Kira Kh Kim; Lev G Magazanik; Denis B Tikhonov
Blockade of NMDA receptor channels by 9-aminoacridine and its derivatives.
Neuroscience letters 2009;451(1):29-33.
2008: Iva Bruhova; Denis B Tikhonov; Boris S Zhorov
Access and binding of local anesthetics in the closed sodium channel.
Molecular pharmacology 2008;74(4):1033-45.
2008: Denis B Tikhonov; Boris S Zhorov
Molecular modeling of benzothiazepine binding in the L-type calcium channel.
The Journal of biological chemistry 2008;283(25):17594-604.
2008: Denis B Tikhonov
Mechanisms of action of ligands of potential-dependent sodium channels.
Neuroscience and behavioral physiology 2008;38(5):461-9.
2008: TB Tikhonova; O I Barygin; VE Gmiro; Denis B Tikhonov; Lev G Magazanik
Organic blockers escape from trapping in the AMPA receptor channels by leaking into the cytoplasm.
Neuropharmacology 2008;54(4):653-64.
2007: Denis B Tikhonov; Boris S Zhorov
Sodium channels: ionic model of slow inactivation and state-dependent drug binding.
Biophysical journal 2007;93(5):1557-70.
2007: Sho-Ya Wang; Denis B Tikhonov; Jane Mitchell; Boris S Zhorov; Ging Kuo Wang
Irreversible block of cardiac mutant Na+ channels by batrachotoxin.
Channels (Austin, Tex.) 2007;1(3):179-88.
2007: Sho-Ya Wang; Denis B Tikhonov; Boris S Zhorov; Jane Mitchell; Ging Kuo Wang
Serine-401 as a batrachotoxin- and local anesthetic-sensing residue in the human cardiac Na+ channel.
Pflügers Archiv : European journal of physiology 2007;454(2):277-87.
2007: Denis B Tikhonov
Ion channels of glutamate receptors: structural modeling.
Molecular membrane biology 2007;24(2):135-47.
2007: Lev G Magazanik; Denis B Tikhonov; TB Tikhonova; N Ya Lukomskaya
Mechanisms of the blockade of glutamate channel receptors: significance for structural and physiological investigations.
Neuroscience and behavioral physiology 2007;37(3):277-84.
2007: SL Buldakova; K K Kim; Denis B Tikhonov; Lev G Magazanik
Selective blockade of Ca2+ permeable AMPA receptors in CA1 area of rat hippocampus.
Neuroscience 2007;144(1):88-99.
2006: Denis B Tikhonov; Iva Bruhova; Boris S Zhorov
Atomic determinants of state-dependent block of sodium channels by charged local anesthetics and benzocaine.
FEBS letters 2006;580(26):6027-32.
2006: Trine F Andersen; Denis B Tikhonov; Ulrik Bølcho; Konstantin Bolshakov; Jared K Nelson; Florentina Pluteanu; Ian R Mellor; Jan Egebjerg; Kristian Strømgaard
Uncompetitive antagonism of AMPA receptors: Mechanistic insights from studies of polyamine toxin derivatives.
Journal of medicinal chemistry 2006;49(18):5414-23.
2006: Sho-Ya Wang; Jane Mitchell; Denis B Tikhonov; Boris S Zhorov; Ging Kuo Wang
How batrachotoxin modifies the sodium channel permeation pathway: computer modeling and site-directed mutagenesis.
Molecular pharmacology 2006;69(3):788-95.
2006: Lev G Magazanik; Denis B Tikhonov; TB Tikhonova; NIa Lukomskaia
[Mechanisms of blockade of glutamate receptors channels: the significance for structural and physiological investigations].
Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 2006;92(1):27-38.
2005: Natalia A Dorofeeva; Denis B Tikhonov; O I Barygin; TB Tikhonova; Y I Salnikov; Lev G Magazanik
Action of extracellular divalent cations on native alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors.
Journal of neurochemistry 2005;95(6):1704-12.
2005: SL Buldakova; Denis B Tikhonov; Lev G Magazanik
Analysis of the excitatory and inhibitory components of postsynaptic currents recorded in pyramidal neurons and interneurons in the rat hippocampus.
Neuroscience and behavioral physiology 2005;35(8):835-43.
2005: Denis B Tikhonov; Boris S Zhorov
Sodium channel activators: model of binding inside the pore and a possible mechanism of action.
FEBS letters 2005;579(20):4207-12.
2005: Konstantin Bolshakov; K H Kim; N N Potapjeva; VE Gmiro; Denis B Tikhonov; Peter N R Usherwood; Ian R Mellor; Lev G Magazanik
Design of antagonists for NMDA and AMPA receptors.
Neuropharmacology 2005;49(2):144-55.
2005: Denis B Tikhonov; Boris S Zhorov
Modeling P-loops domain of sodium channel: homology with potassium channels and interaction with ligands.
Biophysical journal 2005;88(1):184-97.
2004: Denis B Tikhonov; Boris S Zhorov
In silico activation of KcsA K+ channel by lateral forces applied to the C-termini of inner helices.
Biophysical journal 2004;87(3):1526-36.
2004: SL Buldakova; Denis B Tikhonov; Lev G Magazanik
[Analysis of excitatory and inhibitory components of postsynaptic currents recorded in the pyramidal neurons and interneurons of the rat hippocampus].
Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 2004;90(8):945-56.
2004: Denis B Tikhonov; Ian R Mellor; Peter N R Usherwood
Modeling noncompetitive antagonism of a nicotinic acetylcholine receptor.
Biophysical journal 2004;87(1):159-70.
2004: Boris S Zhorov; Denis B Tikhonov
Potassium, sodium, calcium and glutamate-gated channels: pore architecture and ligand action.
Journal of neurochemistry 2004;88(4):782-99.
2003: Tim J Brier; Ian R Mellor; Denis B Tikhonov; Ioana Neagoe; Zuoyi Shao; Matt J Brierley; Kristian Strømgaard; Jerzy W Jaroszewski; Povl Krogsgaard-Larsen; Peter N R Usherwood
Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors.
Molecular pharmacology 2003;64(4):954-64.
2003: Konstantin Bolshakov; VE Gmiro; Denis B Tikhonov; Lev G Magazanik
Determinants of trapping block of N-methyl-d-aspartate receptor channels.
Journal of neurochemistry 2003;87(1):56-65.
2003: Lev G Magazanik; Denis B Tikhonov; KV Bol'shakov; VE Gmiro; SL Buldakova; MV Samoilova
Studies of the structure of glutamate receptor ion channels and the mechanisms of their blockade by organic cations.
Neuroscience and behavioral physiology 2003;33(3):237-46.
2002: Denis B Tikhonov; Jan R Mellor; Peter N R Usherwood; Lev G Magazanik
Modeling of the pore domain of the GLUR1 channel: homology with K+ channel and binding of channel blockers.
Biophysical journal 2002;82(4):1884-93.
2002: Lev G Magazanik; KV Bol'shakov; SL Buldakova; VE Gmiro; Natalia A Dorofeeva; N Ya Lukomskaya; N N Potap'eva; MV Samoilova; Denis B Tikhonov; IM Fedorova; Elena V Frolova
Structural characteristics of ionotropic glutamate receptors as identified by channel blockade.
Neuroscience and behavioral physiology 2002;32(2):173-82.
2002: Konstantin Bolshakov; K V Essin; SL Buldakova; Natalia A Dorofeeva; Serguei N Skatchkov; Misty J Eaton; Denis B Tikhonov; Lev G Magazanik
Characterization of acid-sensitive ion channels in freshly isolated rat brain neurons.
Neuroscience 2002;110(4):723-30.
2001: Lev G Magazanik; Denis B Tikhonov; K B Bol'shakov; VE Gmiro; SL Buldakova; M V Samoĭlova
[Structure of glutamate receptor ion channels and mechanisms of their blockade by organic cations].
Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 2001;87(8):1026-39.
2000: Kristian Strømgaard; Tim J Brier; Kim Andersen; Ian R Mellor; A Saghyan; Denis B Tikhonov; Peter N R Usherwood; Povl Krogsgaard-Larsen; Jerzy W Jaroszewski
Solid-phase synthesis and biological evaluation of a combinatorial library of philanthotoxin analogues.
Journal of medicinal chemistry 2000;43(23):4526-33.
2000: Konstantin Bolshakov; Denis B Tikhonov; VE Gmiro; Lev G Magazanik
Different arrangement of hydrophobic and nucleophilic components of channel binding sites in N-methyl-D-aspartate and AMPA receptors of rat brain is revealed by channel blockade.
Neuroscience letters 2000;291(2):101-4.
2000: SL Buldakova; Konstantin Bolshakov; Denis B Tikhonov; Lev G Magazanik
Ca2+-dependent desensitization of AMPA receptors.
Neuroreport 2000;11(13):2937-41.
2000: Lev G Magazanik; KV Bol'shakov; SL Buldakova; VE Gmiro; Natalia A Dorofeeva; NIa Lukomskaia; N N Potap'eva; M V Samoĭlova; Denis B Tikhonov; IM Fedorova; Elena V Frolova
[Structural characteristics of ionotropic glutamate receptors revealed by channel blockade].
Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 2000;86(9):1138-51.
2000: Denis B Tikhonov; Lev G Magazanik; Ian R Mellor; Peter N R Usherwood
Possible influence of intramolecular hydrogen bonds on the three-dimensional structure of polyamine amides and their interaction with ionotropic glutamate receptors.
Receptors & channels 2000;7(3):227-36.
2000: Denis B Tikhonov; MV Samoilova; SL Buldakova; VE Gmiro; Lev G Magazanik
Voltage-dependent block of native AMPA receptor channels by dicationic compounds.
British journal of pharmacology 2000;129(2):265-74.
1999: Denis B Tikhonov; Boris S Zhorov; Lev G Magazanik
Intersegment hydrogen bonds as possible structural determinants of the N/Q/R site in glutamate receptors.
Biophysical journal 1999;77(4):1914-26.
1998: Denis B Tikhonov; Boris S Zhorov
Kinked-helices model of the nicotinic acetylcholine receptor ion channel and its complexes with blockers: simulation by the Monte Carlo minimization method.
Biophysical journal 1998;74(1):242-55.
1998: Denis B Tikhonov; Lev G Magazanik
Voltage dependence of open channel blockade: onset and offset rates.
The Journal of membrane biology 1998;161(1):1-8.
1996: N B Brovtsyna; Denis B Tikhonov; O B Gorbunova; VE Gmiro; S E Serduk; N Y Lukomskaya; Lev G Magazanik; Boris S Zhorov
Architecture of the neuronal nicotinic acetylcholine receptor ion channel at the binding site of bis-ammonium blockers.
The Journal of membrane biology 1996;152(1):77-87.