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François Tillequin

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Publications

TOP 3
Tuba Serbetçi; Seher Birteksöz; Sylvie Michel; Soizic Prado; François Tillequin
Synthesis and antimicrobial activities of some sulphur containing chromene derivatives.
Ludovic Donati; Vincent Gandon; Pascale Leproux; Sylvie Michel; Elise Prost; François Tillequin; François-Hugues Porée
Solvent/base effects in the selective domino synthesis of phenanthridinones that involves high-valent palladium species: experimental and theoretical studies.
Maria Halabalaki; Sofia Mitakou; Aristea Paschali; François Tillequin; Aurélie Urbain; Alexios-Leandros Skaltsounis
Quercetin and kaempferol 3-O-[α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside]-7-O-α-L-rhamnopyranosides from Anthyllis hermanniae: structure determination and conformational studies.

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All Publications

2012: Tuba Serbetçi; Seher Birteksöz; Sylvie Michel; Soizic Prado; François Tillequin
Synthesis and antimicrobial activities of some sulphur containing chromene derivatives.
Natural product communications 2012;7(7):891-4.
2011: Ludovic Donati; Vincent Gandon; Pascale Leproux; Sylvie Michel; Elise Prost; François Tillequin; François-Hugues Porée
Solvent/base effects in the selective domino synthesis of phenanthridinones that involves high-valent palladium species: experimental and theoretical studies.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(45):12809-19.
2011: Maria Halabalaki; Sofia Mitakou; Aristea Paschali; François Tillequin; Aurélie Urbain; Alexios-Leandros Skaltsounis
Quercetin and kaempferol 3-O-[α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside]-7-O-α-L-rhamnopyranosides from Anthyllis hermanniae: structure determination and conformational studies.
Journal of natural products 2011;74(9):1939-45.
2011: Constance Genès; Gaëlle Lenglet; Sabine Depauw; Raja Nhili; Soizic Prado; Marie-Hélène David-Cordonnier; Sylvie Michel; François Tillequin; François-Hugues Porée
Synthesis and biological evaluation of N-substituted benzo[c]phenanthrolines and benzo[c]phenanthrolinones as antiproliferative agents.
European journal of medicinal chemistry 2011;46(6):2117-31.
2011: Thomas Gaslonde; Fabiola Covello; Laura Velazquez-Alonso; Stéphane Léonce; Alain Pierré; Bruno Pfeiffer; Sylvie Michel; François Tillequin
Synthesis and cytotoxic activity of benzo[a]acronycine and benzo[b]acronycine substituted on the A ring.
European journal of medicinal chemistry 2011;46(5):1861-73.
2011: Sylvia Tiana Ralambonirina Rasoarivelo; Raphaël Grougnet; Philippe Vérité; Marylin Lecsö; Marie-José Butel; François Tillequin; Christiane Rakotobe Guillou; Brigitte Deguin
Chemical composition and antimicrobial activity of the essential oils of Anthospermum emirnense and Anthospermum perrieri (Rubiaceae).
Chemistry & biodiversity 2011;8(1):145-54.
2010: Aikaterini Termentzi; Inana Khouri; Thomas Gaslonde; Soizic Prado; Brigitte Saint-Joanis; Fabienne Bardou; Elsa P Amanatiadou; Ioannis S Vizirianakis; Jana Kordulakova; Mary Jackson; Roland Brosch; Yves L Janin; Mamadou Daffé; François Tillequin; Sylvie Michel
Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring.
European journal of medicinal chemistry 2010;45(12):5833-47.
2010: Nancy Ty; Grégory Dupeyre; Guy G Chabot; Johanne Seguin; Lionel Quentin; Angèle Chiaroni; François Tillequin; Daniel Scherman; Sylvie Michel; Xavier Cachet
Structure-activity relationships of indole compounds derived from combretastatin A4: synthesis and biological screening of 5-phenylpyrrolo[3,4-a]carbazole-1,3-diones as potential antivascular agents.
European journal of medicinal chemistry 2010;45(9):3726-39.
2010: Victor Kuete; Marlise D J Dongfack; Armelle T Mbaveng; Marie-Christine Lallemand; Hanh T Van-Dufat; Jean Duplex Wansi; Elisabeth Seguin; François Tillequin; Jean Wandji
Antimicrobial activity of the methanolic extract and compounds from the stem bark of Drypetes tessmanniana.
Chinese journal of integrative medicine 2010;16(4):337-43.
2010: Tuba Serbetçi; Constance Genès; Sabine Depauw; Soizic Prado; François-Hugues Porée; Marie-Paule Hildebrand; Marie-Hélène David-Cordonnier; Sylvie Michel; François Tillequin
Synthesis and biological evaluation of dialkylaminoalkylamino benzo[c][1,7] and [1,8]phenanthrolines as antiproliferative agents.
European journal of medicinal chemistry 2010;45(6):2547-58.
2010: Vokatsoa C Rakotondramasy; Christine Mouriès; Xavier Cachet; Abdelhak Neghra; Missam El Mourabet; François Tillequin; Michel Koch; Brigitte Deguin
A novel series of cytotoxic iridoid glucosides derived from aucubin: design, synthesis and structure-activity relationships.
European journal of medicinal chemistry 2010;45(6):2314-20.
2010: Marco Bonesi; Monica Rosa Loizzo; Giancarlo A Statti; Sylvie Michel; François Tillequin; Francesco Menichini
The synthesis and angiotensin converting enzyme (ACE) inhibitory activity of chalcones and their pyrazole derivatives.
Bioorganic & medicinal chemistry letters 2010;20(6):1990-3.
2010: Augustine Ahmadu; Agunu Abdulkarim; Raphaël Grougnet; vassilios myrianthopoulos; François Tillequin; Prokopios Magiatis; Alexios-Leandros Skaltsounis
Two new peltogynoids from Acacia nilotica Delile with kinase inhibitory activity.
Planta medica 2010;76(5):458-60.
2010: Sabrina Boutefnouchet; Nguyen Tuan Minh; Rana Putrus; Bruno Pfeiffer; Stéphane Léonce; Alain Pierré; Sylvie Michel; François Tillequin; Marie-Christine Lallemand
Synthesis and cytotoxic activity of psorospermin and acronycine analogues in the 3-propyloxy-acridin-9(10H)-one and -benzo[b]acridin-125H-one series.
European journal of medicinal chemistry 2010;45(2):581-7.
2010: Ludovic Donati; Sylvie Michel; François Tillequin; François-Hugues Porée
Selective unusual Pd-mediated biaryl coupling reactions: solvent effects with carbonate bases.
Organic letters 2010;12(1):156-8.
2009: Sabine Depauw; Thomas Gaslonde; Stéphane Léonce; Laurence Kraus-Berthier; William Laine; Gaëlle Lenglet; Angèle Chiaroni; Bruno Pfeiffer; Christian Bailly; Sylvie Michel; François Tillequin; Alain Pierré; Marie-Hélène David-Cordonnier
Influence of the stereoisomeric position of the reactive acetate groups of the benzo[b]acronycine derivative S23906-1 on its DNA alkylation, helix-opening, cytotoxic, and antitumor activities.
Molecular pharmacology 2009;76(6):1172-85.
2009: David Dako Chiozem; Hanh Trinh-Van-Dufat; Jean Duplex Wansi; Céline Mbazoa Djama; Véronique Simone Fannang; Elisabeth Seguin; François Tillequin; Jean Wandji
New friedelane triterpenoids with antimicrobial activity from the stems of Drypetes paxii.
Chemical & pharmaceutical bulletin 2009;57(10):1119-22.
2009: Q C Nguyen; T T Nguyen; R Yougnia; Thomas Gaslonde; H Dufat; Sylvie Michel; François Tillequin
Acronycine derivatives: a promising series of anticancer agents.
Anti-cancer agents in medicinal chemistry 2009;9(7):804-15.
2009: François Tillequin
[Trehala, a meeting point between zoology, botany, chemistry, and biochemistry].
Revue d'histoire de la pharmacie 2009;57(362):163-72.
2009: Rosa Tundis; Marco Bonesi; Brigitte Deguin; Monica Rosa Loizzo; Francesco Menichini; Filomena Conforti; François Tillequin; Francesco Menichini
Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae).
Bioorganic & medicinal chemistry 2009;17(13):4542-7.
2009: Mariana Laundry de Mesquita; José Elias de Paula; Cláudia Pessoa; Manoel Odorico De Moraes; Letícia Veras Costa-Lotufo; Raphael Grougnet; Sylvie Michel; François Tillequin; Laila Salmen Espindola
Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines.
Journal of ethnopharmacology 2009;123(3):439-45.
2009: Luke Alvey; Soizic Prado; Brigitte Saint-Joanis; Sylvie Michel; Michel Koch; Stewart T Cole; François Tillequin; Yves L Janin
Diversity-oriented synthesis of furo[3,2-f]chromanes with antimycobacterial activity.
European journal of medicinal chemistry 2009;44(6):2497-505.
2009: Hung The Nguyen; Marie-Christine Lallemand; Sabrina Boutefnouchet; Sylvie Michel; François Tillequin
Antitumor psoropermum xanthones and sarcomelicope acridones: privileged structures implied in DNA alkylation.
Journal of natural products 2009;72(3):527-39.
2009: Quyên Do; Wen Tian; Rodrigue Yougnia; Thomas Gaslonde; Bruno Pfeiffer; Alain Pierré; Stéphane Léonce; Laurence Kraus-Berthier; Marie-Hélène David-Cordonnier; Sabine Depauw; Amélie Lansiaux; Romain Mazinghien; Michel Koch; François Tillequin; Sylvie Michel; Hanh Dufat
Synthesis, cytotoxic activity, and DNA binding properties of antitumor cis-1,2-dihydroxy-1,2-dihydrobenzo[b]acronycine cinnamoyl esters.
Bioorganic & medicinal chemistry 2009;17(5):1918-27.
2009: Simon Suh Awanchiri; Hanh Trinh-Van-Dufat; Jovita Chi Shirri; Marlise Diane J Dongfack; Guy Merlin Nguenang; Sabrina Boutefnouchet; Zacharias Tanee Fomum; Elisabeth Seguin; Philippe Verite; François Tillequin; Jean Wandji
Triterpenoids with antimicrobial activity from Drypetes inaequalis.
Phytochemistry 2009;70(3):419-23.
2008: Quyên Do; Huong Doan Thi Mai; Thomas Gaslonde; Bruno Pfeiffer; Stéphane Léonce; Alain Pierré; Sylvie Michel; François Tillequin; Hanh Dufat
Structure-activity relationships in the acronycine and benzo[b]acronycine series: role of the pyran ring.
European journal of medicinal chemistry 2008;43(12):2677-87.
2008: Sabrina Boutefnouchet; Nicolas Gaboriaud-Kolar; Tuan Minh Nguyen; Sabine Depauw; Marie-Hélène David-Cordonnier; Bruno Pfeiffer; Stéphane Léonce; Alain Pierré; François Tillequin; Marie-Christine Lallemand; Sylvie Michel
Synthesis, cytotoxic activity, and mechanism of action of furo[2,3-c]acridin-6-one and benzo[b]furo[3,2-h]acridin-6-one analogues of psorospermin and acronycine.
Journal of medicinal chemistry 2008;51(22):7287-97.
2008: Marco Bonesi; Rosa Tundis; Brigitte Deguin; Monica Rosa Loizzo; Francesco Menichini; François Tillequin; Francesco Menichini
In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines.
Bioorganic & medicinal chemistry letters 2008;18(20):5431-4.
2008: Marlise Diane Jiofack Dongfack; Hanh Trinh Van-Dufat; Marie-Christine Lallemand; Jean Duplex Wansi; Elisabeth Seguin; François Tillequin; Jean Wandji
New triterpenoids from the stem barks of Drypetes tessmanniana.
Chemical & pharmaceutical bulletin 2008;56(9):1321-3.
2008: Luke Alvey; Soizic Prado; Valérie Huteau; Brigitte Saint-Joanis; Sylvie Michel; Michel Koch; Stewart T Cole; François Tillequin; Yves L Janin
A new synthetic access to furo[3,2-f]chromene analogues of an antimycobacterial.
Bioorganic & medicinal chemistry 2008;16(17):8264-72.
2008: Nancy Ty; Grégory Dupeyre; Guy G. Chabot; Johanne Seguin; François Tillequin; Daniel Scherman; Sylvie Michel; Xavier Cachet
Synthesis and biological evaluation of new disubstituted analogues of 6-methoxy-3-(3',4',5'-trimethoxybenzoyl)-1H-indole (BPR0L075), as potential antivascular agents.
Bioorganic & medicinal chemistry 2008;16(15):7494-503.
2008: François Tillequin
[Henri Moissan and opium].
Revue d'histoire de la pharmacie 2008;55(356):485-94.
2008: François Ngandeu; Merhatibeb Bezabih; Dieudonne Ngamga; Alembert T Tchinda; Bonaventure T Ngadjui; Berhanu M Abegaz; Hanh Dufat; François Tillequin
Rotenoid derivatives and other constituents of the twigs of Millettia duchesnei.
Phytochemistry 2008;69(1):258-63.
2007: Jean Duplex Wansi; Marie-Christine Lallemand; David Daco Chiozem; Flavien Aristide A Toze; Luc Meva'a Mbaze; Shamsun Naharkhan; Muhammad Choudhary Iqbal; François Tillequin; Jean Wandji; Zacharias Tanee Fomum
alpha-Glucosidase inhibitory constituents from stem bark of Terminalia superba (Combretaceae).
Phytochemistry 2007;68(15):2096-100.
2007: Boubekeur Badji; Abdellah Mostefaoui; Nasserdine Sabaou; Ahmed Lebrihi; Florence Mathieu; Elisabeth Seguin; François Tillequin
Isolation and partial characterization of antimicrobial compounds from a new strain Nonomuraea sp. NM94.
Journal of industrial microbiology & biotechnology 2007;34(6):403-12.
2007: Thomas Gaslonde; Sylvie Michel; Michel Koch; Bruno Pfeiffer; Stéphane Léonce; Alain Pierré; François Tillequin
Synthesis and cytotoxic activity of dimeric analogs of acronycine in the benzo[b]pyrano[3,2-h]acridin-7-one series.
Chemical & pharmaceutical bulletin 2007;55(5):734-8.
2007: Soizic Prado; Yves L Janin; Brigitte Saint-Joanis; Priscille Brodin; Sylvie Michel; Michel Koch; Stewart T Cole; François Tillequin; Pierre-Etienne Bost
Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues.
Bioorganic & medicinal chemistry 2007;15(5):2177-86.
2007: Sofia Mitaku; Nikolas Fokialakis; Prokopios Magiatis; François Tillequin
Alkaloids from Sarcomelicope megistophylla.
Fitoterapia 2007;78(2):169-70.
2007: François Tillequin
[The Musée de Matière Médicale of the Paris pharmacy faculty and its collections].
Veröffentlichungen der Schweizerischen Gesellschaft für Geschichte der Pharmazie / herausgegeben vom Vorstand der Schweizerischen Gesellschaft für Geschichte der Pharmazie (SGGP) 2007;28():157-65.
2007: Vokatsoa Christian Rakotondramasy; Raphaël Laschiazza; Marylin Lecsö-Bornet; Michel Koch; François Tillequin; Brigitte Deguin
Regioselective and stereospecific amination of iridoids: conversion of aucubin into aminoside antibiotic analogues.
Journal of natural products 2007;70(1):19-23.
2006: Raphaël Grougnet; Prokopios Magiatis; Sofia Mitaku; Stella Loizou; paraskevi moutsatsou; Aris Terzis; Pierre Cabalion; François Tillequin; Sylvie Michel
seco-Cycloartane triterpenes from Gardenia aubryi.
Journal of natural products 2006;69(12):1711-4.
2006: Raphaël Grougnet; Prokopios Magiatis; Sofia Mitaku; Aris Terzis; François Tillequin; Alexios-Leandros Skaltsounis
New lignans from the perisperm of Sesamum indicum.
Journal of agricultural and food chemistry 2006;54(20):7570-4.
2006: Chavalit Sittisombut; Sabrina Boutefnouchet; Hanh Trinh Van-Dufat; Wen Tian; Sylvie Michel; Michel Koch; François Tillequin; Bruno Pfeiffer; Alain Pierré
Synthesis and cytotoxic activity of benzo[a]pyrano[3,2-h] and [2,3-i]xanthone analogues of psorospermine, acronycine, and benzo[a]acronycine.
Chemical & pharmaceutical bulletin 2006;54(8):1113-8.
2006: Soizic Prado; Hervé Ledeit; Sylvie Michel; Michel Koch; Jacques-Christian Darbord; Stewart T Cole; François Tillequin; Priscille Brodin
Benzofuro[3,2-f][1]benzopyrans: a new class of antitubercular agents.
Bioorganic & medicinal chemistry 2006;14(15):5423-8.
2006: Grégory Dupeyre; Guy G Chabot; Sylviane Thoret; Xavier Cachet; Johanne Seguin; Daniel Guénard; François Tillequin; Daniel Scherman; Michel Koch; Sylvie Michel
Synthesis and biological evaluation of (3,4,5-trimethoxyphenyl)indol-3-ylmethane derivatives as potential antivascular agents.
Bioorganic & medicinal chemistry 2006;14(13):4410-26.
2006: Tuan Minh Nguyen; Chavalit Sittisombut; Sabrina Boutefnouchet; Marie-Christine Lallemand; Sylvie Michel; Michel Koch; François Tillequin; Romain Mazinghien; Amélie Lansiaux; Marie-Hélène David-Cordonnier; Bruno Pfeiffer; Laurence Kraus-Berthier; Stéphane Léonce; Alain Pierré
Synthesis, antitumor activity, and mechanism of action of benzo[a]pyrano[3,2-h]acridin-7-one analogues of acronycine.
Journal of medicinal chemistry 2006;49(11):3383-94.
2006: Jean Duplex Wansi; Jean Wandji; W A F Kamdem; Jean Claude Ndom; H E Ngeufa; D D Chiozem; J Chi Shirri; M I Choudhary; Nole Tsabang; François Tillequin; Zacharias Tanee Fomum
Triterpenoids from Drypetes chevalieri Beille (euphorbiaceae).
Natural product research 2006;20(6):586-92.
2006: Jean Duplex Wansi; Jean Wandji; Luc Mbaze Meva'a; Alain François Kamdem Waffo; Rose Ranjit; Shamsun Nahar Khan; Azaz Asma; Choudhary Muhammad Iqbal; Marie-Christine Lallemand; François Tillequin; Zacharias Fomum Tanee
Alpha-glucosidase inhibitory and antioxidant acridone alkaloids from the stem bark of Oriciopsis glaberrima ENGL. (Rutaceae).
Chemical & pharmaceutical bulletin 2006;54(3):292-6.
2006: Delphine Roux; Frédéric Muyard; Corinne Girard; Michel Colombain; François Tillequin; Peter G Waterman; Françoise Bévalot
Phebaclavin I, a novel 3-prenylated coumarin, and trichoclin acetate, a new natural furocoumarin, from the aerial parts of Phebalium aff. tuberculosum (Rutaceae).
Natural product research 2006;20(3):279-83.
2005: Jean-Bernard Bongui; Abdelhakim Elomri; Dominique Cahard; François Tillequin; Bruno Pfeiffer; Alain Pierré; Elisabeth Seguin
Synthesis and cytotoxic activity of acronycine analogues in the benzo[c]pyrano[3,2-h]acridin-7-one and naphtho[1,2-b][1,7] and [1,10]-phenanthrolin-7(14H)-one series.
Chemical & pharmaceutical bulletin 2005;53(12):1540-6.
2005: Rosa Tundis; Brigitte Deguin; Monica Rosa Loizzo; Marco Bonesi; Giancarlo A Statti; François Tillequin; Francesco Menichini
Potential antitumor agents: flavones and their derivatives from Linaria reflexa Desf.
Bioorganic & medicinal chemistry letters 2005;15(21):4757-60.
2005: Huong Doan Thi Mai; Thomas Gaslonde; Sylvie Michel; Michel Koch; François Tillequin; Christian Bailly; Marie-Hélène David-Cordonnier; Bruno Pfeiffer; Stéphane Léonce; Alain Pierré
Design, synthesis, and cytotoxic activity of Michael acceptors and enol esters in the benzo[b]acronycine series.
Chemical & pharmaceutical bulletin 2005;53(8):919-22.
2005: Alice Martins; Michael Wink; Andreas Tei; Michèle Brum-Bousquet; François Tillequin; Amélia P Rauter
A phytochemical study of the quinolizidine alkaloids from Genista tenera by gas chromatography-mass spectrometry.
Phytochemical analysis : PCA 2005;16(4):264-6.
2005: Raphaël Grougnet; Prokopios Magiatis; Nikolas Fokialakis; Sofia Mitaku; Alexios-Leandros Skaltsounis; François Tillequin; Thierry Sévenet; Marc Litaudon
Koniamborine, the first pyrano[3,2-b]indole alkaloid and other secondary metabolites from Boronella koniambiensis.
Journal of natural products 2005;68(7):1083-6.
2005: A Kabouche; N Boutaghane; Zahia Kabouche; Elisabeth Seguin; François Tillequin; K Benlabed
Components and antibacterial activity of the roots of Salvia jaminiana.
Fitoterapia 2005;76(5):450-2.
2005: Christine Borrel; Sylviane Thoret; Xavier Cachet; Daniel Guénard; François Tillequin; Michel Koch; Sylvie Michel
New antitubulin derivatives in the combretastatin A4 series: synthesis and biological evaluation.
Bioorganic & medicinal chemistry 2005;13(11):3853-64.
2005: Christine Mouriès; Vokatsoa C Rakotondramasy; Francine Libot; Michel Koch; François Tillequin; Brigitte Deguin
Synthesis and cytotoxicity of a novel iridoid glucoside derived from aucubin.
Chemistry & biodiversity 2005;2(5):695-703.
2005: Elisabeth Seguin; François Tillequin
[Structure activity relationships and mechanism of action of antitumor benzo[b]acronycine antitumor agents].
Annales pharmaceutiques françaises 2005;63(1):44-52.
2005: François Tillequin; M Koch
[Acronycine revisited: development of benzo[b]acronycine antitumor agents].
Annales pharmaceutiques françaises 2005;63(1):35-43.
2005: Marie-Hélène David-Cordonnier; William Laine; Amélie Lansiaux; Frédéric Rosu; Pierre Colson; Edwin De Pauw; Sylvie Michel; François Tillequin; Michel Koch; John A Hickman; Alain Pierré; Christian Bailly
Covalent binding of antitumor benzoacronycines to double-stranded DNA induces helix opening and the formation of single-stranded DNA: unique consequences of a novel DNA-bonding mechanism.
Molecular cancer therapeutics 2005;4(1):71-80.
2004: Tony Tite; Marie-Christine Lallemand; Erwan Poupon; Nicole Kunesch; François Tillequin; Christine Gravier-Pelletier; Yves Le Merrer; Henri-Philippe Husson
Synthesis of polyhydroxylated piperidines and evaluation as glycosidase inhibitors.
Bioorganic & medicinal chemistry 2004;12(19):5091-7.
2004: Sylvie Michel; Thomas Gaslonde; François Tillequin
Benzo[b]acronycine derivatives: a novel class of antitumor agents.
European journal of medicinal chemistry 2004;39(8):649-55.
2004: Soizic Prado; Sylvie Michel; François Tillequin; Michel Koch; Bruno Pfeiffer; Alain Pierré; Stéphane Léonce; Pierre Colson; Brigitte Baldeyrou; Amélie Lansiaux; Christian Bailly
Synthesis and cytotoxic activity of benzo[c][1,7] and [1,8]phenanthrolines analogues of nitidine and fagaronine.
Bioorganic & medicinal chemistry 2004;12(14):3943-53.
2004: Hong Anh Tran-Thi; Thuan Nguyen-Thi; Sylvie Michel; François Tillequin; Michel Koch; Bruno Pfeiffer; Alain Pierré; Hanh Trinh-Van-Dufat
Synthesis and cytotoxic activity of pyranocarbazole analogues of ellipticine and acronycine.
Chemical & pharmaceutical bulletin 2004;52(5):540-5.
2004: Konstantia Graikou; Nektarios Aligiannis; Alexios-Leandros Skaltsounis; Ioanna Chinou; Sylvie Michel; François Tillequin; Marc Litaudon
New diterpenes from Croton insularis.
Journal of natural products 2004;67(4):685-8.
2004: Marie-Hélène David-Cordonnier; William Laine; Thomas Gaslonde; Sylvie Michel; François Tillequin; Michel Koch; Stéphane Léonce; Alain Pierré; Christian Bailly
Design of novel antitumor DNA alkylating agents: the benzacronycine series.
Current medicinal chemistry. Anti-cancer agents 2004;4(2):83-92.
2004: Huong Doan Thi Mai; Thomas Gaslonde; Sylvie Michel; Michel Koch; François Tillequin; Bruno Pfeiffer; Pierre Renard; Laurence Kraus-Berthier; Stéphane Léonce; Alain Pierré
Synthesis and cytotoxic and antitumor activity of 1,2-dihydroxy-1,2-dihydrobenzo[b]acronycine diacid hemiesters and carbamates.
Chemical & pharmaceutical bulletin 2004;52(3):293-7.
2004: Marie-Hélène David-Cordonnier; William Laine; Mostafa Kouach; Gilbert Briand; Hervé Vezin; Thomas Gaslonde; Sylvie Michel; Huong Doan Thi Mai; François Tillequin; Michel Koch; Stéphane Léonce; Alain Pierré; Christian Bailly
A transesterification reaction is implicated in the covalent binding of benzo[b]acronycine anticancer agents with DNA and glutathion.
Bioorganic & medicinal chemistry 2004;12(1):23-9.
2003: Jean Wandji; François Tillequin; Dulcie A Mulholland; Jovita Chi Shirri; Nole Tsabang; Elisabeth Seguin; Philippe Verite; Francine Libot; Zacharias Tanee Fomum
Pentacyclic triterpenoid and saponins from Gambeya boukokoensis.
Phytochemistry 2003;64(4):845-9.
2003: Naòma Benkiki; Zahia Kabouche; François Tillequin; Philippe Vérité; Elizabeth Chosson; Elisabeth Seguin
A new polyisoprenylated phloroglucinol derivative from Hypericum perfoliatum (Clusiaceae).
Zeitschrift für Naturforschung. C, Journal of biosciences 2003;58(9-10):655-8.
2003: Huong Doan Thi Mai; Thomas Gaslonde; Sylvie Michel; François Tillequin; Michel Koch; Jean-Bernard Bongui; Abdelhakim Elomri; Elisabeth Seguin; Bruno Pfeiffer; Pierre Renard; Marie-Hélène David-Cordonnier; William Laine; Christian Bailly; Laurence Kraus-Berthier; Stéphane Léonce; John A Hickman; Alain Pierré
Structure-activity relationships and mechanism of action of antitumor benzo[b]pyrano[3,2-h]acridin-7-one acronycine analogues.
Journal of medicinal chemistry 2003;46(14):3072-82.
2003: Marie-Hélène David-Cordonnier; William Laine; Alexandra Joubert; Christelle Tardy; Jean-François Goossens; Mostafa Kouach; Gilbert Briand; Huong Doan Thi Mai; Sylvie Michel; François Tillequin; Michel Koch; stephane leonce; Alain Pierre; Christian Bailly
Covalent binding to glutathione of the DNA-alkylating antitumor agent, S23906-1.
European journal of biochemistry / FEBS 2003;270(13):2848-59.
2003: Nikolas Fokialakis; Prokopios Magiatis; Sofia Mitaku; Harris Pratsinis; François Tillequin
Estrogenic activity of phenylpropanoids from Sarcomelicope megistophylla and structure determination of a new norneolignan.
Planta medica 2003;69(6):566-8.
2003: Jean Wandji; François Tillequin; Dulcie A Mulholland; Agathe D Temgoua; Jean Duplex Wansi; Elisabeth Seguin; Zacharias Tanee Fomum
Phenolic constituents from Drypetes armoracia.
Phytochemistry 2003;63(4):453-6.
2003: Nadine Costes; Abdelhakim Elomri; Hanh Dufat; Sylvie Michel; Elisabeth Seguin; Michel Koch; François Tillequin; Bruno Pfeiffer; Pierre Renard; Stéphane Léonce; Alain Pierré
Synthesis of 6-dialkylaminoalkylamino pyrano[2,3-c]acridones and benzo[b]pyrano[3,2-h]acridones: soluble acronycine analogues with increased cytotoxic activity.
Oncology research 2003;13(4):191-7.
2002: Quang An Nguyen; Hanh Trinh Van-Dufat; Sylvie Michel; François Tillequin; Vincent Dumontet; Thierry Sévenet
A new phenylpropanoid ester from the bark of Zanthoxylum scandens (Rutaceae).
Zeitschrift für Naturforschung. C, Journal of biosciences 2002;57(11-12):986-9.
2002: Jean Wandji; François Tillequin; Dulcie A Mulholland; Jean Duplex Wansi; Tanee Z Fomum; Victorine Fuendjiep; Francine Libot; Nole Tsabang
Fatty acid esters of triterpenoids and steroid glycosides from Gambeya africana.
Planta medica 2002;68(9):822-6.
2002: Sylvie Michel; Elisabeth Seguin; François Tillequin
Structure-activity relationships in the acronycine series.
Current medicinal chemistry 2002;9(18):1689-700.
2002: Lynda Lamari; Abdelghani Zitouni; Tahar Dob; Nasserdine Sabaou; Ahmed Lebrihi; Pierre Germain; Elisabeth Seguin; François Tillequin
New dithiolopyrrolone antibiotics from Saccharothrix sp. SA 233. II. Physicochemical properties and structure elucidation.
The Journal of antibiotics 2002;55(8):702-6.
2002: Lynda Lamari; Abdelghani Zitouni; Hadjira Boudjella; Boubekeur Badji; Nasserdine Sabaou; Ahmed Lebrihi; Gérard Lefebvre; Elisabeth Seguin; François Tillequin
New dithiolopyrrolone antibiotics from Saccharothrix sp. SA 233. I. Taxonomy, fermentation, isolation and biological activities.
The Journal of antibiotics 2002;55(8):696-701.
2002: Victorine Fuendjiep; Jean Wandji; François Tillequin; Dulcie A Mulholland; H Budzikiewicz; Zacharias Tanee Fomum; A M Nyemba; M Koch
Chalconoid and stilbenoid glycosides from Guibourtia tessmanii.
Phytochemistry 2002;60(8):803-6.
2002: François Tillequin
[New antitumor agents in the acronycine series].
Annales pharmaceutiques françaises 2002;60(4):246-52.
2002: Elisabeth Seguin; Abdelhakim Elomri; Prokopios Magiatis; Alexios-Leandros Skaltsounis; Lin Rui Chao; François Tillequin
Synthesis, dimerization, and biological activity of hexaoxygenated chalcones related to calythropsin and combretastatins.
Natural product letters 2002;16(3):187-93.
2002: Nicolas Guilbaud; Stéphane Léonce; François Tillequin; Michel Koch; John A Hickman; Alain Pierré
Acronycine derivatives as promising antitumor agents.
Anti-cancer drugs 2002;13(5):445-9.
2002: Prokopios Magiatis; Alexios-Leandros Skaltsounis; François Tillequin; Elisabeth Seguin; Jean-Pierre Cosson
Coelobillardin, an iridoid glucoside dimer from Coelospermum billardieri.
Phytochemistry 2002;60(4):415-8.
2002: Michel Colombain; Corinne Girard; Frédéric Muyard; Françoise Bévalot; François Tillequin; Peter G Waterman
Eight new prenylcoumarins from Phebalium clavatum.
Journal of natural products 2002;65(4):458-61.
2002: Nikolas Fokialakis; Prokopios Magiatis; Ioanna Chinou; Sofia Mitaku; François Tillequin
Megistoquinones I and II, two quinoline alkaloids with antibacterial activity from the bark of Sarcomelicope megistophylla.
Chemical & pharmaceutical bulletin 2002;50(3):413-4.
2002: Christine Debue-Barazer; Geneviève Baudouin; François Tillequin
[Poppy, opium and associated objects in the museum of Materia Medica of the Faculty of Pharmacy].
Revue d'histoire de la pharmacie 2002;50(336):555-68.
2002: Corinne Girard; Michel Colombain; Frédéric Muyard; Françoise Bévalot; François Tillequin; Peter G Waterman
Prenylated p-coumarates from the twigs of Phebalium rude subsp. amblycarpum (Rutaceae).
Zeitschrift für Naturforschung. C, Journal of biosciences 2002;57(1-2):39-41.
2001: Stéphane Léonce; V Pérez; S Lambel; D Peyroulan; François Tillequin; Sylvie Michel; M Koch; Bruno Pfeiffer; Ghanem Atassi; John A Hickman; Alain Pierré
Induction of cyclin E and inhibition of DNA synthesis by the novel acronycine derivative S23906-1 precede the irreversible arrest of tumor cells in S phase leading to apoptosis.
Molecular pharmacology 2001;60(6):1383-91.
2001: Prokopios Magiatis; Sofia Mitaku; Alexios-Leandros Skaltsounis; François Tillequin
1-Oxo-2-hydroxy-1,2-dihydroacronycine: a useful synthon in the acronycine series for the introduction of amino substituents at 6-position and for the conversion into isopropylfuroacridones.
Chemical & pharmaceutical bulletin 2001;49(10):1304-7.
2001: Jean-Bernard Bongui; Abdelhakim Elomri; Elisabeth Seguin; François Tillequin; Bruno Pfeiffer; Pierre Renard; Alain Pierré; Ghanem Atassi
Synthesis and cytotoxic activity of benzophenanthrolinone analogues of acronycine.
Chemical & pharmaceutical bulletin 2001;49(9):1077-80.
2001: Nicolas Guilbaud; Laurence Kraus-Berthier; F Meyer-Losic; V Malivet; C Chacun; M Jan; François Tillequin; Sylvie Michel; M Koch; Bruno Pfeiffer; Ghanem Atassi; John Hickman; Alain Pierré
Marked antitumor activity of a new potent acronycine derivative in orthotopic models of human solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(8):2573-80.
2001: H D Mai; H T Van-Dufat; Sylvie Michel; François Tillequin; D Bastien; Thierry Sévenet
A new diprenyl coumarin and alkaloids from the bark of Zanthoxylum dimorphophyllum (Rutaceae).
Zeitschrift für Naturforschung. C, Journal of biosciences 2001;56(7-8):492-4.
2001: Chavalit Sittisombut; Nadine Costes; Sylvie Michel; Michel Koch; François Tillequin; Bruno Pfeiffer; Pierre Renard; Alain Pierré; Ghanem Atassi
Synthesis and cytotoxic activity of benzopyranoxanthone analogues of benz.
Chemical & pharmaceutical bulletin 2001;49(6):675-9.
2001: Nikolas Fokialakis; Prokopios Magiatis; Nektarios Aligiannis; Sofia Mitaku; François Tillequin; Thierry Sévenet
Furomegistines I and II, two furanopyridine alkaloids from the bark of Sarcomelicope megistophylla.
Phytochemistry 2001;57(4):593-6.
2001: Panagiotis Polychronopoulos; Prokopios Magiatis; Alexios-Leandros Skaltsounis; François Tillequin; E Vardala-Theodorou; ANTHONY TSARBOPOULOS
Homarine, a common metabolite in edible Mediterranean molluscs: occurrence, spectral data and revision of a related structure.
Natural product letters 2001;15(6):411-8.
2001: Y Ranarivelo; P Magiatis; Alexios-Leandros Skaltsounis; François Tillequin
Selective amination of secoiridoid glycosides to give monomeric pyridine, dimeric pyridine, and naphthyridine alkaloids.
Natural product letters 2001;15(2):131-7.
2000: Nikolas Fokialakis; Prokopios Magiatis; Sofia Mitaku; François Tillequin; Thierry Sévenet
Two new 3-methoxy-4-quinolone alkaloids from the bark of Sarcomelicope megistophylla.
Chemical & pharmaceutical bulletin 2000;48(12):2009-10.
2000: Nikolas Fokialakis; Prokopios Magiatis; Alexios-Leandros Skaltsounis; François Tillequin; Thierry Sévenet
Megistolactone, a new alkaloid from Sarcomelicope megistophylla.
Zeitschrift für Naturforschung. C, Journal of biosciences 2000;55(11-12):874-6.
2000: Jean Wandji; Jean Duplex Wansi; Victorine Fuendjiep; E Dagne; Dulcie A Mulholland; François Tillequin; Zacharias Tanee Fomum; Beibam Lucas Sondengam; Benedicta Chungag; Dieudonné Njamen
Sesquiterpene lactone and friedelane derivative from drypetes molunduana.
Phytochemistry 2000;54(8):811-5.
2000: Nikolas Fokialakis; Prokopios Magiatis; Alexios-Leandros Skaltsounis; François Tillequin; Thierry Sévenet
The structure of sarcomejine: an application of long-range (1)H-(15)N correlation at natural abundance.
Journal of natural products 2000;63(7):1004-5.
2000: Nadine Costes; H Le Deit; Sylvie Michel; François Tillequin; Michel Koch; Bruno Pfeiffer; Pierre Renard; Stéphane Léonce; Nicolas Guilbaud; Laurence Kraus-Berthier; Alain Pierré; Ghanem Atassi
Synthesis and cytotoxic and antitumor activity of benzo[b]pyrano[3, 2-h]acridin-7-one analogues of acronycine.
Journal of medicinal chemistry 2000;43(12):2395-402.
2000: Angèle Chiaroni; Claude Riche; Xavier Cachet; Brigitte Deguin; M Koch; François Tillequin
(1S,4R,5R,6R)-6-methoxycarbonyl-4-pivaloyloxy-2-(pivaloyloxymethyl)- bicyclo[3.1.0]hex-2-ene-1-carboxylic acid.
Acta crystallographica. Section C, Crystal structure communications 2000;56 ( Pt 3)():358-9.
2000: M Papageorgiou; Nikolas Fokialakis; Sofia Mitaku; Alexios-Leandros Skaltsounis; François Tillequin; Thierry Sévenet
Two new alkaloids from the bark of Sarcomelicope megistophylla.
Journal of natural products 2000;63(3):385-6.
2000: Véronique Seidel; M Verholle; Y Malard; François Tillequin; J C Fruchart; Patrick Duriez; François Bailleul; E Teissier
Phenylpropanoids from Ballota nigra L. inhibit in vitro LDL peroxidation.
Phytotherapy research : PTR 2000;14(2):93-8.
2000: R Pernin; Frédéric Muyard; Françoise Bévalot; François Tillequin; J Vaquette
Efficient synthesis of octandrenolone and related dipyranoacetophenones.
Journal of natural products 2000;63(2):245-7.
2000: Dominique A Daels-Rakotoarison; Véronique Seidel; Bernard Gressier; Claude Brunet; François Tillequin; François Bailleul; Michel Luyckx; Thierry Dine; M Cazin; Jean Claude Cazin
Neurosedative and antioxidant activities of phenylpropanoids from ballota nigra.
Arzneimittel-Forschung 2000;50(1):16-23.
1999: Nikolas Fokialakis; Sofia Mitaku; Emmanuel Mikros; Alexios-Leandros Skaltsounis; François Tillequin; T Sevenet
Megistosarcimine and megistosarconine, two alkaloids from Sarcomelicope megistophylla.
Phytochemistry 1999;52(8):1745-8.
1999: N Didry; Véronique Seidel; L Dubreuil; François Tillequin; François Bailleul
Isolation and antibacterial activity of phenylpropanoid derivatives from Ballota nigra.
Journal of ethnopharmacology 1999;67(2):197-202.
1999: Abdelhakim Elomri; Sylvie Michel; Michel Koch; Elisabeth Seguin; François Tillequin; Alain Pierré; Ghanem Atassi
Synthesis and cytotoxic activity of 11-nitro and 11-amino derivatives of acronycine and 6-demethoxyacronycine.
Chemical & pharmaceutical bulletin 1999;47(11):1604-6.
1999: Prokopios Magiatis; Sofia Mitaku; Alexios-Leandros Skaltsounis; François Tillequin; M Koch; Alain Pierré; Ghanem Atassi
Synthesis and cytotoxic activity of 1-alkoxy- and 1-amino-2-hydroxy-1,2-dihydroacronycine derivatives.
Chemical & pharmaceutical bulletin 1999;47(5):611-4.
1999: Nadine Costes; Sylvie Michel; François Tillequin; Michel Koch; Alain Pierré; Ghanem Atassi
Chiral dihydroxylation of acronycine: absolute configuration of natural cis-1,2-dihydroxy-1,2-dihydroacronycine and cytotoxicity of (1R,2R)- and (1S,2S)-1,2-diacetoxy-1,2-dihydroacronycine.
Journal of natural products 1999;62(3):490-2.
1998: Prokopios Magiatis; Sofia Mitaku; Alexios-Leandros Skaltsounis; François Tillequin; M Koch; Alain Pierré; Ghanem Atassi
Synthesis and biological activity of esters in the trans-1,2-dihydroxy-1,2-dihydroacronycine series.
Journal of natural products 1998;61(2):198-201.
1998: Véronique Seidel; François Bailleul; François Tillequin
[Diterpene and phenylpropanoid heteroside esters from Ballota nigra L].
Annales pharmaceutiques françaises 1998;56(1):31-5.
1998: J Razafimbelo; G Baudouin; François Tillequin; Pierre Renard; Stéphane Léonce; Alain Pierré; Ghanem Atassi
Synthesis and cytotoxic activity of pyranophenanthridine analogues of fagaronine and acronycine.
Chemical & pharmaceutical bulletin 1998;46(1):34-41.
1997: Véronique Seidel; François Bailleul; Francine Libot; François Tillequin
A phenylpropanoid glycoside from Ballota nigra.
Phytochemistry 1997;44(4):691-3.
1996: A Elomri; Sofia Mitaku; Sylvie Michel; Alexios-Leandros Skaltsounis; François Tillequin; Michel Koch; Alain Pierré; Nicolas Guilbaud; Stéphane Léonce; Laurence Kraus-Berthier; Y Rolland; Ghanem Atassi
Synthesis and cytotoxic and antitumor activity of esters in the 1,2-dihydroxy-1,2-dihydroacronycine series.
Journal of medicinal chemistry 1996;39(24):4762-6.
1996: A Elomri; Alexios-Leandros Skaltsounis; Sylvie Michel; François Tillequin; Michel Koch; Y Rolland; Alain Pierré; Ghanem Atassi
Synthesis and cytotoxic activity of acronycine derivatives modified at the pyran ring.
Chemical & pharmaceutical bulletin 1996;44(11):2165-8.
1996: A Rabemanantsoa; Y Ranarivelo; M Andriantsiferana; François Tillequin; J V Silverton; H Martin Garraffo; Thomas F Spande; H J Yeh; John W Daly
A new secotrinervitane diterpene isolated from soldiers of the Madagascan termite species, Nasutitermes canaliculatus.
Journal of natural products 1996;59(9):883-6.
1996: Sofia Mitaku; Alexios-Leandros Skaltsounis; François Tillequin; Michel Koch; Y Rolland; Alain Pierré; Ghanem Atassi
Synthesis and anti-proliferative activity of 2-hydroxy-1,2-dihydroacronycine glycosides.
Pharmaceutical research 1996;13(6):939-43.
1996: Véronique Seidel; François Bailleul; François Tillequin
Phenylpropanoid glycosides from Ballota nigra.
Planta medica 1996;62(2):186-7.
1995: M Azoulay; Jean-Claude Florent; Claude Monneret; Jean-Pierre Gesson; J C Jacquesy; François Tillequin; Michel Koch; Klaus Bosslet; J Czech; D Hoffman
Prodrugs of anthracycline antibiotics suited for tumor-specific activation.
Anti-cancer drug design 1995;10(6):441-50.
1994: Jean-Pierre Gesson; J C Jacquesy; M Mondon; P Petit; B Renoux; S Andrianomenjanahary; H Dufat-Trinh Van; Michel Koch; Sylvie Michel; François Tillequin
Prodrugs of anthracyclines for chemotherapy via enzyme-monoclonal antibody conjugates.
Anti-cancer drug design 1994;9(5):409-23.
1994: C Demetzos; Alexios-Leandros Skaltsounis; B Razanamahefa; François Tillequin
Synthesis of quercetin-3-O-beta-D-glucopyranosyl-(1-->2)-beta-D- xylopyranoside via orthoester methodology.
Journal of natural products 1994;57(9):1234-8.
1994: L K Basco; Sofia Mitaku; Alexios-Leandros Skaltsounis; N Ravelomanantsoa; François Tillequin; Michel Koch; J Le Bras
In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum.
Antimicrobial agents and chemotherapy 1994;38(5):1169-71.
1994: R C Lin; Alexios-Leandros Skaltsounis; Elisabeth Seguin; François Tillequin; Michel Koch
Phenolic Constituents of Selaginella doederleinii.
Planta medica 1994;60(2):168-70.
1994: C Demetzos; Alexios-Leandros Skaltsounis; Sylvie Michel; François Tillequin; Michel Koch; M Anstett; S Leonce; Alain Pierré; Ghanem Atassi
Synthesis and biological activity of 3'-deamino-3'-haloanthracyclines.
Anti-cancer drug design 1994;9(2):129-37.
1992: X Dong; François Tillequin; Claude Monneret; G Horvath; F Sztaricskai
Synthesis of a phenyl beta-avobioside derivative of the disaccharide component of avoparcins.
Carbohydrate research 1992;232(1):107-15.
1991: R Benkrief; Alexios-Leandros Skaltsounis; François Tillequin; Michel Koch; J Pusset
Iridoids and an Alkaloid from Oxera morieri1.
Planta medica 1991;57(1):79-80.
1990: C Demetzos; Alexios-Leandros Skaltsounis; François Tillequin; Michel Koch
Phase-transfer-catalyzed synthesis of flavonoid glycosides.
Carbohydrate research 1990;207(1):131-7.
1990: Y Ranarivelo; Alexios-Leandros Skaltsounis; M Andriantsiferana; François Tillequin
[Glycosides from Mussaenda arcuata Lam. ex Poiret leaves].
Annales pharmaceutiques françaises 1990;48(5):273-7.
1989: H Dufat-Trinh Van; E Seguin; François Tillequin; Claude Monneret; M Koch
[Total synthesis of oxa-9-anthracyclines].
Chemical & pharmaceutical bulletin 1989;37(12):3294-300.
1989: Alexios-Leandros Skaltsounis; François Tillequin; Michel Koch; J Pusset; G Chauvière
Iridoids from Scaevola racemigera1.
Planta medica 1989;55(2):191-2.
1989: Sofia Mitaku; Alexios-Leandros Skaltsounis; François Tillequin; M Koch; J Pusset
[Plants from New Caledonia. Alkaloids from Sarcomelicope dogniensis Hartley stem bark].
Annales pharmaceutiques françaises 1989;47(3):149-56.
1988: G Baudouin; Alexios-Leandros Skaltsounis; François Tillequin; Michel Koch
Lugrandoside: a new phenylpropanoid glycoside from various digitalis species.
Planta medica 1988;54(4):321-3.
1985: M Brum-Bousquet; François Tillequin; Michel Koch; Thierry Sévenet
Alkaloids from Sarcomelicope argyrophylla1.
Planta medica 1985;51(6):536-7.