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Helen Tinwell

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Procedures

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Anatomy

Chemicals & Drugs

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Physiology

Genes & Molecular Sequences

Lac Operon

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Co-Publications
Name
69
Ashby, John
23
Lefevre, Paul
16
Odum, Jenny
5
Kimber, Ian
5
Schmezer, Peter
5
Soames, Anthony
5
Joiner, Ronald
4
Pate, Ian
4
Paton, D
4
Orphanides, George
3
Lim, Fei Ling
3
Moggs, Jonathan
3
Haseman, J
3
Brooks, AN
3
Van Miller, John

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Publications

TOP 3
Rouquié David; Friry-Santini Claire; Schorsch Frédéric; Tinwell Helen; Bars Rémi
Standard and molecular NOAELs for rat testicular toxicity induced by flutamide.
Tinwell Helen; Friry-Santini Claire; Rouquié David; Belluco Sara; Elies Laetitia; Pallen Catherine; Bars Remi
Evaluation of the antiandrogenic effects of flutamide, DDE, and linuron in the weanling rat assay using organ weight, histopathological, and proteomic approaches.
Friry-Santini Claire; Rouquié David; Kennel Philippe; Tinwell Helen; Benahmed Mohamed; Bars Rémi
Correlation between protein accumulation profiles and conventional toxicological findings using a model antiandrogenic compound, flutamide.

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All Publications

2009: Rouquié David; Friry-Santini Claire; Schorsch Frédéric; Tinwell Helen; Bars Rémi
Standard and molecular NOAELs for rat testicular toxicity induced by flutamide.
Toxicological sciences : an official journal of the Society of Toxicology 2009;109(1):59-65.
2007: Tinwell Helen; Friry-Santini Claire; Rouquié David; Belluco Sara; Elies Laetitia; Pallen Catherine; Bars Remi
Evaluation of the antiandrogenic effects of flutamide, DDE, and linuron in the weanling rat assay using organ weight, histopathological, and proteomic approaches.
Toxicological sciences : an official journal of the Society of Toxicology 2007;100(1):54-65.
2007: Friry-Santini Claire; Rouquié David; Kennel Philippe; Tinwell Helen; Benahmed Mohamed; Bars Rémi
Correlation between protein accumulation profiles and conventional toxicological findings using a model antiandrogenic compound, flutamide.
Toxicological sciences : an official journal of the Society of Toxicology 2007;97(1):81-93.
2006: Stuckey Ruth; Aldridge Tom; Lim Fei Ling; Moore David J; Tinwell Helen; Doherty Nicola; Davies Reginald; Smith Andrew G; Kimber Ian; Ashby John; Orphanides George; Moggs Jonathan G
Induction of iron homeostasis genes during estrogen-induced uterine growth and differentiation.
Molecular and cellular endocrinology 2006;253(1-2):22-9.
2004: Moggs Jonathan G; Tinwell Helen; Spurway Tracey; Chang Hur-Song; Pate Ian; Lim Fei Ling; Moore David J; Soames Anthony; Stuckey Ruth; Currie Richard; Zhu Tong; Kimber Ian; Ashby John; Orphanides George
Phenotypic anchoring of gene expression changes during estrogen-induced uterine growth.
Environmental health perspectives 2004;112(16):1589-606.
2004: Odum Jenny; Tinwell Helen; Tobin Graham; Ashby John
Cumulative dietary energy intake determines the onset of puberty in female rats.
Environmental health perspectives 2004;112(15):1472-80.
2004: Moggs Jonathan G; Ashby John; Tinwell Helen; Lim Fei Ling; Moore David J; Kimber Ian; Orphanides George
The need to decide if all estrogens are intrinsically similar.
Environmental health perspectives 2004;112(11):1137-42.
2004: Ashby John; Tinwell Helen; Odum Jenny; Lefevre Paul
Natural variability and the influence of concurrent control values on the detection and interpretation of low-dose or weak endocrine toxicities.
Environmental health perspectives 2004;112(8):847-53.
2004: Tinwell Helen; Ashby John
Sensitivity of the immature rat uterotrophic assay to mixtures of estrogens.
Environmental health perspectives 2004;112(5):575-82.
2004: Ashby J; Lefevre P A; Tinwell H; Odum J; Owens W
Testosterone-stimulated weanlings as an alternative to castrated male rats in the Hershberger anti-androgen assay.
Regulatory toxicology and pharmacology : RTP 2004;39(2):229-38.
2003: Ashby John; Owens William; Odum Jenny; Tinwell Helen
The intact immature rodent uterotrophic bioassay: possible effects on assay sensitivity of vomeronasal signals from male rodents and strain differences.
Environmental health perspectives 2003;111(12):1568-70.
2003: Ashby John; Pate Ian; Tinwell Helen
Reported seasonal dependence of herbicide developmental toxicity in mice.
Environmental health perspectives 2003;111(9):A450-1.
2003: Ashby J; Tinwell H; Lefevre P A; Joiner R; Haseman J
The effect on sperm production in adult Sprague-Dawley rats exposed by gavage to bisphenol A between postnatal days 91-97.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(1):129-38.
2002: Tinwell H; Haseman J; Lefevre P A; Wallis N; Ashby J
Normal sexual development of two strains of rat exposed in utero to low doses of bisphenol A.
Toxicological sciences : an official journal of the Society of Toxicology 2002;68(2):339-48.
2002: Odum J; Lefevre P A; Tinwell H; Van Miller J P; Joiner R L; Chapin R E; Wallis N T; Ashby J
Comparison of the developmental and reproductive toxicity of diethylstilbestrol administered to rats in utero, lactationally, preweaning, or postweaning.
Toxicological sciences : an official journal of the Society of Toxicology 2002;68(1):147-63.
2002: Ashby J; Tinwell H; Stevens J; Pastoor T; Breckenridge C B
The effects of atrazine on the sexual maturation of female rats.
Regulatory toxicology and pharmacology : RTP 2002;35(3):468-73.
2002: Tinwell Helen; Lefevre Paul A; Moffat Graeme J; Burns A; Odum Jenny; Spurway T D; Orphanides George; Ashby John
Confirmation of uterotrophic activity of 3-(4-methylbenzylidine)camphor in the immature rat.
Environmental health perspectives 2002;110(5):533-6.
2001: Ashby J; Tinwell H; Plautz J; Twomey K; Lefevre P A
Lack of binding to isolated estrogen or androgen receptors, and inactivity in the immature rat uterotrophic assay, of the ultraviolet sunscreen filters Tinosorb M-active and Tinosorb S.
Regulatory toxicology and pharmacology : RTP 2001;34(3):287-91.
2001: Ashby J; Odum J; Tinwell H
Predictive value of the uterotrophic assay for genistein carcinogenicity in the neonatal mouse: relevance to infants consuming soy-based formula.
Environmental health perspectives 2001;109(12):A568-70.
2001: Ashby J; Tinwell H; Odum J
DNA adducts, estrogenicity and rodent diets.
Mutation research 2001;483(1-2):105-6.
2001: Ashby J; Tinwell H
Continuing ability of the rodent bone marrow micronucleus assay to act as a predictor of the possible germ cell mutagenicity of chemicals.
Mutation research 2001;478(1-2):211-3.
2001: Odum J; Tinwell H; Jones K; Van Miller J P; Joiner R L; Tobin G; Kawasaki H; Deghenghi R; Ashby J
Effect of rodent diets on the sexual development of the rat.
Toxicological sciences : an official journal of the Society of Toxicology 2001;61(1):115-27.
2001: Tinwell H; Brinkworth M H; Ashby J
Further evidence for the rodent bone marrow micronucleus assay acting as a sensitive predictor of the possible germ cell mutagenicity of chemicals.
Mutation research 2001;473(2):259-61.
2001: Odum J; Tinwell H; Van Miller J; Joiner R; Ashby J
The uterotrophic activity of nonylphenol in the rat is not mediated by aromatase enzyme induction.
Toxicology letters 2001;118(3):165-9.
2000: Ashby J; Tinwell H; Odum J; Kimber I; Brooks A N; Pate I; Boyle C C
Diet and the aetiology of temporal advances in human and rodent sexual development.
Journal of applied toxicology : JAT 2000;20(5):343-7.
2000: Tinwell H; Joiner R; Pate I; Soames A; Foster J; Ashby J
Uterotrophic activity of bisphenol A in the immature mouse.
Regulatory toxicology and pharmacology : RTP 2000;32(1):118-26.
2000: Tinwell H; Soames A R; Foster J R; Ashby J
Estradiol-type activity of coumestrol in mature and immature ovariectomized rat uterotrophic assays.
Environmental health perspectives 2000;108(7):631-4.
2000: Ashby J; Tinwell H; Odum J
Uterotrophic activity of a "phytoestrogen-free" rat diet.
Environmental health perspectives 2000;108(1):A12-3.
1999: Ashby J; Tinwell H; Haseman J
Lack of effects for low dose levels of bisphenol A and diethylstilbestrol on the prostate gland of CF1 mice exposed in utero.
Regulatory toxicology and pharmacology : RTP 1999;30(2 Pt 1):156-66.
1999: Ashby J; Tinwell H; Soames A; Foster J
Induction of hyperplasia and increased DNA content in the uterus of immature rats exposed to coumestrol.
Environmental health perspectives 1999;107(10):819-22.
1999: Ashby J; Tinwell H; Pennie W; Brooks A N; Lefevre P A; Beresford N; Sumpter J P
Partial and weak oestrogenicity of the red wine constituent resveratrol: consideration of its superagonist activity in MCF-7 cells and its suggested cardiovascular protective effects.
Journal of applied toxicology : JAT 1999;19(1):39-45.
1999: Fletcher K; Soames A R; Tinwell H; Lefevre P A; Ashby J
Hepatic gene mutations induced in Big Blue rats by both the potent rat liver azo-carcinogen 6BT and its reported noncarcinogenic analogue 5BT.
Environmental and molecular mutagenesis 1999;34(2-3):148-53.
1998: Ashby J; Tinwell H
Oestrogenic activity of burgen bread to female rats.
Human & experimental toxicology 1998;17(11):598-9.
1998: Ashby J; Tinwell H
Uterotrophic activity of bisphenol A in the immature rat.
Environmental health perspectives 1998;106(11):719-20.
1998: Fletcher K; Tinwell H; Ashby J
Mutagenicity of the human bladder carcinogen 4-aminobiphenyl to the bladder of MutaMouse transgenic mice.
Mutation research 1998;400(1-2):245-50.
1998: Williams C V; Fletcher K; Tinwell H; Ashby J
Mutagenicity of ethyl carbamate to lacZ- transgenic mice.
Mutagenesis 1998;13(2):133-7.
1998: Tinwell H; Lefevre P A; Ashby J
Relative activities of methyl methanesulphonate (MMS) as a genotoxin, clastogen and gene mutagen to the liver and bone marrow of MutaMouse mice.
Environmental and molecular mutagenesis 1998;32(2):163-72.
1997: Ashby J; Fletcher K; Williams C; Odum J; Tinwell H
Lack of activity of estradiol in rodent bone marrow micronucleus assays.
Mutation research 1997;395(1):83-8.
1997: Ashby J; Tinwell H; Lefevre P A; Williams J; Kier L; Adler I D; Clapp M J
Evaluation of the mutagenicity of acetochlor to male rat germ cells.
Mutation research 1997;393(3):263-81.
1997: Ashby J; Tinwell H; Lefevre P A; Odum J; Paton D; Millward S W; Tittensor S; Brooks A N
Normal sexual development of rats exposed to butyl benzyl phthalate from conception to weaning.
Regulatory toxicology and pharmacology : RTP 1997;26(1 Pt 1):102-18.
1997: Ashby J; Lefevre P A; Odum J; Tinwell H; Kennedy S J; Beresford N; Sumpter J P
Failure to confirm estrogenic activity for benzoic acid and clofibrate: implications for lists of endocrine-disrupting agents.
Regulatory toxicology and pharmacology : RTP 1997;26(1 Pt 1):96-101.
1997: Ashby J; Odum J; Tinwell H; Lefevre P A
Assessing the risks of adverse endocrine-mediated effects: where to from here?
Regulatory toxicology and pharmacology : RTP 1997;26(1 Pt 1):80-93.
1997: Yendle J E; Tinwell H; Elliott B M; Ashby J
The genetic toxicity of time: importance of DNA-unwinding time to the outcome of single-cell gel electrophoresis assays.
Mutation research 1997;375(2):125-36.
1997: Tinwell H; Lefevre P; Williams C V; Ashby J
The activity of ENU, iPMS and MMS in male mouse germ cells using the Muta Mouse positive selection transgenic mutation assay.
Mutation research 1997;388(2-3):179-85.
1997: Lefevre P A; Tinwell H; Ashby J
Mutagenicity of the potent rat hepatocarcinogen 6BT to the liver of transgenic (lacI) rats: consideration of a reduced mutation assay protocol.
Mutagenesis 1997;12(1):45-7.
1996: Tinwell H; Ashby J; Williams C V
Presence of alpha-lactose in some batches of proprietary LB broth: relevance to the MutaMouse lacZ gene mutation assay.
Mutation research 1996;358(1):123-4.
1996: Tinwell H; Yendle J; Ashby J
Mutagenicity to the mouse bone marrow by the mouse germ cell mutagen N-propyl-N-nitrosourea.
Mutation research 1996;370(3-4):141-3.
1996: Ashby J; Kier L; Wilson A G; Green T; Lefevre P A; Tinwell H; Willis G A; Heydens W F; Clapp M J
Evaluation of the potential carcinogenicity and genetic toxicity to humans of the herbicide acetochlor.
Human & experimental toxicology 1996;15(9):702-35.
1996: Tinwell H; Clapp M J; Ashby J
Fate of unfertilized ova in male rodent dominant lethal assays: extension of the studies by Kratochvilova.
Mutation research 1996;368(3-4):309-17.
1996: Ashby J; Tinwell H
The rodent bone marrow micronucleus assay: contrast between its sensitivity to human carcinogens and its insensitivity to NTP rodent carcinogens.
Mutation research 1996;352(1-2):181-4.
1996: Tinwell H; Paton D; Guttenplan J B; Ashby J
Unexpected genetic toxicity to rodents of the N',N'-dimethyl analogues of MNU and ENU.
Environmental and molecular mutagenesis 1996;27(3):202-10.
1995: Tinwell H; Liegibel U; Krebs O; Schmezer P; Favor J; Ashby J
Comparison of lacI and lacZ transgenic mouse mutation assays: an EU-sponsored interlaboratory study.
Mutation research 1995;335(2):185-90.
1995: Morrison V; Tinwell H; Ashby J
Consideration of the liver of embryonic lacZ transgenic mice as an analogue of the mouse coat colour spot test: preliminary data and technical problems.
Mutation research 1995;329(2):107-12.
1995: Ashby J; Tinwell H
A sequential approach to testing with the rodent bone marrow micronucleus assay--obviation of the need for statistical analyses of data.
Mutation research 1995;327(1-2):49-55.
1995: Ashby J; Tinwell H; Lefevre P A; Browne M A
The single cell gel electrophoresis assay for induced DNA damage (comet assay): measurement of tail length and moment.
Mutagenesis 1995;10(2):85-90.
1994: Lefevre P A; Tinwell H; Galloway S M; Hill R; Mackay J M; Elcombe C R; Foster J; Randall V; Callander R D; Ashby J
Evaluation of the genetic toxicity of the peroxisome proliferator and carcinogen methyl clofenapate, including assays using Muta Mouse and Big Blue transgenic mice.
Human & experimental toxicology 1994;13(11):764-75.
1994: Tinwell H; Ashby J
Comparative activity of human carcinogens and NTP rodent carcinogens in the mouse bone marrow micronucleus assay: an integrative approach to genetic toxicity data assessment.
Environmental health perspectives 1994;102(9):758-62.
1994: Tinwell H; Ashby J
Genetic toxicity and potential carcinogenicity of taxol.
Carcinogenesis 1994;15(8):1499-501.
1994: Ashby J; Tinwell H; Weaver R; Cullis P M
Similar activity of chlorambucil and its spermidine conjugate in the mouse bone marrow micronucleus assay.
Mutagenesis 1994;9(4):391-2.
1994: Tinwell H; Lefevre P A; Ashby J
Mutation studies with dimethyl nitrosamine in young and old lac I transgenic mice.
Mutation research 1994;307(2):501-8.
1994: Tinwell H; Lefevre P A; Ashby J
Response of the Muta mouse lacZ/galE- transgenic mutation assay to DMN: comparisons with the corresponding Big Blue (lacI) responses.
Mutation research 1994;307(1):169-73.
1994: Ashby J; Tinwell H; Glover P; Poorman-Allen P; Krehl R; Callander R D; Clive D
Potent clastogenicity of the human carcinogen etoposide to the mouse bone marrow and mouse lymphoma L5178Y cells: comparison to Salmonella responses.
Environmental and molecular mutagenesis 1994;24(1):51-60.
1993: Ashby J; Brusick D; Myhr B C; Jones N J; Parry J M; Nesnow S; Paton D; Tinwell H; Rosenkranz H S; Curti S
Correlation of carcinogenic potency with mouse-skin 32P-postlabeling and muta-Rmouse lac Z- mutation data for DMBA and its K-region sulphur isostere: comparison with activities observed in standard genotoxicity assays.
Mutation research 1993;292(1):25-40.
1993: Ashby J; Tinwell H
Clastogenicity of chlorambucil to the mouse bone marrow: consideration in relation to its genetic specificity of action in some assays.
Mutagenesis 1993;8(4):373-5.
1993: Kennelly J C; Lane M P; Barker J A; Barber G; Tinwell H; Gallagher J E; Pool-Zobel B; Schmezer P; Ashby J
Genotoxic activity of 1-chloromethylpyrene in stomach epithelium in vivo: insensitivity of the stomach scintillation UDS assay.
Carcinogenesis 1993;14(4):637-43.
1993: Ashby J; Vogel E W; Tinwell H; Callander R D; Shuker D E
Mutagenicity to Salmonella, Drosophila and the mouse bone marrow of the human antineoplastic agent fotemustine: prediction of carcinogenic potency.
Mutation research 1993;286(1):101-9.
1992: Liegibel U; Tinwell H; Callander R D; Schmezer P; Ashby J
Clastogenicity to the mouse bone marrow of the mouse germ cell genotoxin streptozotocin.
Mutagenesis 1992;7(6):471-4.
1991: Ashby J; Lefevre P A; Tinwell H; Brunborg G; Schmezer P; Pool-Zobel B; Shanu-Wilson R; Holme J A; Soderlund E J; Gulati D
The non-genotoxicity to rodents of the potent rodent bladder carcinogens o-anisidine and p-cresidine.
Mutation research 1991;250(1-2):115-33.
1991: Ashby J; Tinwell H; Callander R D; Clare N
Genetic activity of the human carcinogen sulphur mustard towards Salmonella and the mouse bone marrow.
Mutation research 1991;257(3):307-11.
1991: Tinwell H; Ashby J
Micronucleus morphology as a means to distinguish aneugens and clastogens in the mouse bone marrow micronucleus assay.
Mutagenesis 1991;6(3):193-8.
1991: Tinwell H; Ashby J
Activity of the human carcinogen MeCCNU in the mouse bone marrow micronucleus assay.
Environmental and molecular mutagenesis 1991;17(3):152-4.
1990: Ashby J; Tinwell H; Callander R D
Activity of urethane and N,N-dimethylurethane in the mouse bone-marrow micronucleus assay: equivalence of oral and intraperitoneal routes of exposure.
Mutation research 1990;245(3):227-30.
1990: Tinwell H; Ashby J
Inactivity of copper sulphate in a mouse bone-marrow micronucleus assay.
Mutation research 1990;245(3):223-6.
1990: Ashby J; Tinwell H; Gulati D; Heddle J A
Overview of the study in relation to protocol design for the rodent bone-marrow micronucleus assay.
Mutation research 1990;234(3-4):223-48.
1990: Ashby J; Tinwell H
The serial dosing rodent bone-marrow micronucleus assay test protocol: context, purpose and design of the collaborative study.
Mutation research 1990;234(3-4):111-4.
1990: Tinwell H; Bandara L; Ashby J
Activity of DMBA, DMH and CP in triple- and single-dose rodent bone-marrow micronucleus assays.
Mutation research 1990;234(3-4):195-8.
1990: Ashby J; Gallagher J E; Kohan M; Tinwell H; Kimber I; Paton D; Callander R D; Chouroulinkov I
1-Chloromethylpyrene: a reference skin sensitizer and genotoxin.
Mutation research 1990;243(4):281-9.
1990: Schmezer P; Pool B L; Lefevre P A; Callander R D; Ratpan F; Tinwell H; Ashby J
Assay-specific genotoxicity of N-nitrosodibenzylamine to the rat liver in vivo.
Environmental and molecular mutagenesis 1990;15(4):190-7.
1989: Tinwell H; Ashby J
Comparison of acridine orange and Giemsa stains in several mouse bone marrow micronucleus assays--including a triple dose study.
Mutagenesis 1989;4(6):476-81.
1989: Ashby J; Richardson C R; Tinwell H
Inactivity of ethyl acrylate in the mouse bone marrow micronucleus assay.
Mutagenesis 1989;4(4):283-5.

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