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Witoon Tirasophon

Research Profile

Anatomy

Endoplasmic Reticulum

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Physiology

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Sutipa Tanapongpipat; Witoon Tirasophon; Toru Watanabe; Yasunori Chiba; Peerada Promdonkoy; Niran Roongsawang; Lily Eurwilaichitr
Heterologous protein expression in Pichia thermomethanolica BCC16875, a thermotolerant methylotrophic yeast and characterization of N-linked glycosylation in secreted protein.
Juthakorn Poothong; Pattarawut Sopha; Randal J Kaufman; Witoon Tirasophon
Domain compatibility in Ire1 kinase is critical for the unfolded protein response.
Witoon Tirasophon; Supansa Yodmuang; Wanlop Chinnirunvong; Nongluk Plongthongkum; Sakol Panyim
Therapeutic inhibition of yellow head virus multiplication in infected shrimps by YHV-protease dsRNA.

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2012: Sutipa Tanapongpipat; Witoon Tirasophon; Toru Watanabe; Yasunori Chiba; Peerada Promdonkoy; Niran Roongsawang; Lily Eurwilaichitr
Heterologous protein expression in Pichia thermomethanolica BCC16875, a thermotolerant methylotrophic yeast and characterization of N-linked glycosylation in secreted protein.
FEMS microbiology letters 2012;334(2):127-34.
2010: Juthakorn Poothong; Pattarawut Sopha; Randal J Kaufman; Witoon Tirasophon
Domain compatibility in Ire1 kinase is critical for the unfolded protein response.
FEBS letters 2010;584(14):3203-8.
2007: Witoon Tirasophon; Supansa Yodmuang; Wanlop Chinnirunvong; Nongluk Plongthongkum; Sakol Panyim
Therapeutic inhibition of yellow head virus multiplication in infected shrimps by YHV-protease dsRNA.
Antiviral research 2007;74(2):150-5.
2007: Nongluk Plongthongkum; Niwed Kullawong; Sakol Panyim; Witoon Tirasophon
Ire1 regulated XBP1 mRNA splicing is essential for the unfolded protein response (UPR) in Drosophila melanogaster.
Biochemical and biophysical research communications 2007;354(3):789-94.
2006: Supansa Yodmuang; Witoon Tirasophon; Yaowaluck Roshorm; Wanlop Chinnirunvong; Sakol Panyim
YHV-protease dsRNA inhibits YHV replication in Penaeus monodon and prevents mortality.
Biochemical and biophysical research communications 2006;341(2):351-6.
2005: Witoon Tirasophon; Yaowaluck Roshorm; Sakol Panyim
Silencing of yellow head virus replication in penaeid shrimp cells by dsRNA.
Biochemical and biophysical research communications 2005;334(1):102-7.
2005: Wanchai Assavalapsakul; Witoon Tirasophon; Sakol Panyim
Antiserum to the gp116 glycoprotein of yellow head virus neutralizes infectivity in primary lymphoid organ cells of Penaeus monodon.
Diseases of aquatic organisms 2005;63(1):85-8.
2002: Kyungho Lee; Witoon Tirasophon; Xiaohua Shen; Marek Michalak; Ron Prywes; Tetsuya Okada; Hiderou Yoshida; Kazutoshi Mori; Randal J Kaufman
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response.
Genes & development 2002;16(4):452-66.
2000: Witoon Tirasophon; Kyungho Lee; B Callaghan; Ajith Welihinda; Randal J Kaufman
The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response.
Genes & development 2000;14(21):2725-36.
2000: Y Wang; Jingshi Shen; N Arenzana; Witoon Tirasophon; Randal J Kaufman; Ron Prywes
Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.
The Journal of biological chemistry 2000;275(35):27013-20.
2000: Ajith Welihinda; Witoon Tirasophon; Randal J Kaufman
The transcriptional co-activator ADA5 is required for HAC1 mRNA processing in vivo.
The Journal of biological chemistry 2000;275(5):3377-81.
1999: Ajith Welihinda; Witoon Tirasophon; Randal J Kaufman
The cellular response to protein misfolding in the endoplasmic reticulum.
Gene expression 1999;7(4-6):293-300.
1998: Witoon Tirasophon; Ajith Welihinda; Randal J Kaufman
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells.
Genes & development 1998;12(12):1812-24.
1998: Ajith Welihinda; Witoon Tirasophon; S R Green; Randal J Kaufman
Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase.
Molecular and cellular biology 1998;18(4):1967-77.
1997: Peng Jiang; P Zucker; Mariette R Atkinson; ES Kamberov; Witoon Tirasophon; P Chandran; B R Schefke; Alexander J Ninfa
Structure/function analysis of the PII signal transduction protein of Escherichia coli: genetic separation of interactions with protein receptors.
Journal of bacteriology 1997;179(13):4342-53.
1997: Ajith Welihinda; Witoon Tirasophon; S R Green; Randal J Kaufman
Gene induction in response to unfolded protein in the endoplasmic reticulum is mediated through Ire1p kinase interaction with a transcriptional coactivator complex containing Ada5p.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4289-94.