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Nigel Titchener-Hooker

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Spyridon Konstantinidis; Sunil Chhatre; Eva Heldin; Simyee Kong; Ajoy Velayudhan; Nigel J Titchener-Hooker
Strategic Assay Selection for analytics in high-throughput process development: case studies for downstream processing of monoclonal antibodies.
Spyridon Konstantinidis; Sunil Chhatre; Eva Heldin; Ajoy Velayudhan; Nigel J Titchener-Hooker
The hybrid experimental simplex algorithm--an alternative method for 'sweet spot' identification in early bioprocess development: case studies in ion exchange chromatography.
Tian Lan; John Langdon; Graeme R Smith; Spyros Gerontas; John M Ward; Nigel J Titchener-Hooker
Investigating the use of column inserts to achieve better chromatographic bed support.

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All Publications

2012: Spyridon Konstantinidis; Sunil Chhatre; Eva Heldin; Simyee Kong; Ajoy Velayudhan; Nigel J Titchener-Hooker
Strategic Assay Selection for analytics in high-throughput process development: case studies for downstream processing of monoclonal antibodies.
Biotechnology journal 2012;7(10):1256-68.
2012: Spyridon Konstantinidis; Sunil Chhatre; Eva Heldin; Ajoy Velayudhan; Nigel J Titchener-Hooker
The hybrid experimental simplex algorithm--an alternative method for 'sweet spot' identification in early bioprocess development: case studies in ion exchange chromatography.
Analytica chimica acta 2012;743():19-32.
2012: Tian Lan; John Langdon; Graeme R Smith; Spyros Gerontas; John M Ward; Nigel J Titchener-Hooker
Investigating the use of column inserts to achieve better chromatographic bed support.
Biotechnology progress 2012;28(5):1285-91.
2012: Spyridon Konstantinidis; Sunil Chhatre; Eva Heldin; Ajoy Velayudhan; Nigel J Titchener-Hooker
Strategic assay deployment as a method for countering analytical bottlenecks in high throughput process development: case studies in ion exchange chromatography.
Biotechnology progress 2012;28(5):1292-302.
2012: Yu-Chih Chang; Spyros Gerontas; Nigel J Titchener-Hooker
Automated methods for accurate determination of the critical velocity of packed bed chromatography.
Biotechnology progress 2012;28(3):740-5.
2011: Sunil Chhatre; Simon Edwards-Parton; Yu Ji; Spyridon Konstantinidis; Yuhong Zhou; Nigel J Titchener-Hooker
The simplex algorithm for the rapid identification of operating conditions during early bioprocess development: case studies in FAb' precipitation and multimodal chromatography.
Biotechnology and bioengineering 2011;108(9):2162-70.
2011: Rihab Boushaba; Spyros Gerontas; Nigel J Titchener-Hooker; Helen Baldascini; Daniel G Bracewell
Demonstration of the use of windows of operation to visualize the effects of fouling on the performance of a chromatographic step.
Biotechnology progress 2011;27(4):1009-17.
2011: Sunil Chhatre; Lars Pampel; Nigel J Titchener-Hooker
Integrated use of ultra scale-down and financial modeling to identify optimal conditions for the precipitation and centrifugal recovery of milk proteins.
Biotechnology progress 2011;27(4):998-1008.
2011: A I Brown; Nigel J Titchener-Hooker; Gary J Lye
Scale-down prediction of industrial scale pleated membrane cartridge performance.
Biotechnology and bioengineering 2011;108(4):830-8.
2010: Sunil Chhatre; Richard Francis; Daniel G Bracewell; Nigel J Titchener-Hooker
An automated packed protein G micro-pipette tip assay for rapid quantification of polyclonal antibodies in ovine serum.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(30):3067-75.
2010: Ying Gao; Katie Kipling; Jarka Glassey; Mark Willis; Gary Montague; Yuhong Zhou; Nigel J Titchener-Hooker
Application of agent-based system for bioprocess description and process improvement.
Biotechnology progress 2010;26(3):706-16.
2010: Carol Knevelman; Jim Davies; Lee Allen; Nigel J Titchener-Hooker
High-throughput screening techniques for rapid PEG-based precipitation of IgG4 mAb from clarified cell culture supernatant.
Biotechnology progress 2010;26(3):697-705.
2010: Gaik Sui Kee; Jing Jin; Bangaru Balasundaram; Daniel G Bracewell; Narahari S Pujar; Nigel J Titchener-Hooker
Exploiting the intracellular compartmentalization characteristics of the S. cerevisiae host cell for enhancing primary purification of lipid-envelope virus-like particles.
Biotechnology progress 2010;26(1):26-33.
2009: Sunil Chhatre; Daniel G Bracewell; Nigel J Titchener-Hooker
A microscale approach for predicting the performance of chromatography columns used to recover therapeutic polyclonal antibodies.
Journal of chromatography. A 2009;1216(45):7806-15.
2009: Gareth J Mannall; James P Myers; John Liddell; Nigel J Titchener-Hooker; Paul A Dalby
Ultra scale-down of protein refold screening in microwells: challenges, solutions and application.
Biotechnology and bioengineering 2009;103(2):329-40.
2008: Sunil Chhatre; Richard Francis; Anthony R Newcombe; Yuhong Zhou; Nigel J Titchener-Hooker; Josh King; Eli Keshavarz-Moore
Global Sensitivity Analysis for the determination of parameter importance in bio-manufacturing processes.
Biotechnology and applied biochemistry 2008;51(Pt 2):79-90.
2008: Richard Tran; Yuhong Zhou; Karol M Lacki; Nigel J Titchener-Hooker
A methodology for the comparative evaluation of alternative bioseparation technologies.
Biotechnology progress 2008;24(5):1007-25.
2008: Nigel J Titchener-Hooker; Peter Dunnill; Mike Hoare
Micro biochemical engineering to accelerate the design of industrial-scale downstream processes for biopharmaceutical proteins.
Biotechnology and bioengineering 2008;100(3):473-87.
2008: Gaik Sui Kee; Narahari S Pujar; Nigel J Titchener-Hooker
Study of detergent-mediated liberation of hepatitis B virus-like particles from S. cerevisiae homogenate: identifying a framework for the design of future-generation lipoprotein vaccine processes.
Biotechnology progress 2008;24(3):623-31.
2008: Sharon Chan; Nigel J Titchener-Hooker; Eva Sørensen
Optimal economic design and operation of single- and multi-column chromatographic processes.
Biotechnology progress 2008;24(2):389-401.
2008: S Edwards-Parton; N F Thornhill; Daniel G Bracewell; J M Liddell; Nigel J Titchener-Hooker
Principal component score modeling for the rapid description of chromatographic separations.
Biotechnology progress 2008;24(1):202-8.
2008: Lars W Pampel; Rihab Boushaba; Nigel J Titchener-Hooker
A methodical approach to ultra-scale-down of process sequences: application to casein removal from the milk of transgenic animals.
Biotechnology progress 2008;24(1):192-201.
2007: Sunil Chhatre; Richard Francis; Nigel J Titchener-Hooker; Anthony R Newcombe; Eli Keshavarz-Moore
Evaluation of a novel agarose-based synthetic ligand adsorbent for the recovery of antibodies from ovine serum.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;860(2):209-17.
2007: Andrew D Tustian; Heidi Salte; Nik Willoughby; Inass Hassan; Michael H Rose; Frank Baganz; Mike Hoare; Nigel J Titchener-Hooker
Adapted ultra scale-down approach for predicting the centrifugal separation behavior of high cell density cultures.
Biotechnology progress 2007;23(6):1404-10.
2007: Sunil Chhatre; Richard Francis; Kieran O'Donovan; Nigel J Titchener-Hooker; Anthony R Newcombe; Eli Keshavarz-Moore
A prototype software methodology for the rapid evaluation of biomanufacturing process options.
Biotechnology and applied biochemistry 2007;48(Pt 2):65-78.
2007: Gareth J Mannall; Nigel J Titchener-Hooker; Paul A Dalby
Factors affecting protein refolding yields in a fed-batch and batch-refolding system.
Biotechnology and bioengineering 2007;97(6):1523-34.
2007: F J Meacle; Hu Zhang; I Papantoniou; John M Ward; Nigel J Titchener-Hooker; Mike Hoare
Degradation of supercoiled plasmid DNA within a capillary device.
Biotechnology and bioengineering 2007;97(5):1148-57.
2007: Sunil Chhatre; Pranavan Thillaivinayagalingam; Richard Francis; Nigel J Titchener-Hooker; Anthony R Newcombe; Eli Keshavarz-Moore
Decision-support software for the industrial-scale chromatographic purification of antibodies.
Biotechnology progress 2007;23(4):888-94.
2007: Richard Tran; John Joseph; Andrew Sinclair; Daniel G Bracewell; Yuhong Zhou; Nigel J Titchener-Hooker
A framework for the prediction of scale-up when using compressible chromatographic packings.
Biotechnology progress 2007;23(2):413-22.
2007: J M P King; Nigel J Titchener-Hooker; Y Zhou
Ranking bioprocess variables using global sensitivity analysis: a case study in centrifugation.
Bioprocess and biosystems engineering 2007;30(2):123-34.
2007: Lars Pampel; Rihab Boushaba; Mike Udell; Mike Turner; Nigel J Titchener-Hooker
The influence of major components on the direct chromatographic recovery of a protein from transgenic milk.
Journal of chromatography. A 2007;1142(2):137-47.
2007: Sunil Chhatre; Nigel J Titchener-Hooker; Anthony R Newcombe; Eli Keshavarz-Moore
Purification of antibodies using the synthetic affinity ligand absorbent MAbsorbent A2P.
Nature protocols 2007;2(7):1763-9.
2007: Sunil Chhatre; Richard Francis; Kieran O'Donovan; Nigel J Titchener-Hooker; Anthony R Newcombe; Eli Keshavarz-Moore
A decision-support model for evaluating changes in biopharmaceutical manufacturing processes.
Bioprocess and biosystems engineering 2007;30(1):1-11.
2006: Heidi Salte; Josh M P King; Frank Baganz; Mike Hoare; Nigel J Titchener-Hooker
A methodology for centrifuge selection for the separation of high solids density cell broths by visualisation of performance using windows of operation.
Biotechnology and bioengineering 2006;95(6):1218-27.
2006: Sun Chau Siu; Rihab Boushaba; Vithaya Topoyassakul; Alex Graham; Sorwar Choudhury; Guy Moss; Nigel J Titchener-Hooker
Visualising fouling of a chromatographic matrix using confocal scanning laser microscopy.
Biotechnology and bioengineering 2006;95(4):714-23.
2006: Kais Lakhdar; Suzanne S Farid; Nigel J Titchener-Hooker; Lazaros G Papageorgiou
Medium term planning of biopharmaceutical manufacture with uncertain fermentation titers.
Biotechnology progress 2006;22(6):1630-6.
2006: Sunil Chhatre; Carl Jones; Richard Francis; Kieran O'Donovan; Nigel J Titchener-Hooker; Anthony R Newcombe; Eli Keshavarz-Moore
The integrated simulation and assessment of the impacts of process change in biotherapeutic antibody production.
Biotechnology progress 2006;22(6):1612-20.
2006: Sun Chau Siu; Helen Baldascini; David C Hearle; Mike Hoare; Nigel J Titchener-Hooker
Effect of fouling on the capacity and breakthrough characteristics of a packed bed ion exchange chromatography column.
Bioprocess and biosystems engineering 2006;28(6):405-14.
2006: Gareth J Mannall; Nigel J Titchener-Hooker; Howard A Chase; Paul A Dalby
A critical assessment of the impact of mixing on dilution refolding.
Biotechnology and bioengineering 2006;93(5):955-63.
2006: Ai Chye Lim; John Washbrook; Nigel J Titchener-Hooker; Suzanne S Farid
A computer-aided approach to compare the production economics of fed-batch and perfusion culture under uncertainty.
Biotechnology and bioengineering 2006;93(4):687-97.
2005: Sally Hassan; Nigel J Titchener-Hooker; Nik Willoughby
Determining particle density distribution of expanded bed adsorbents.
Biotechnology and bioengineering 2005;92(5):659-63.
2005: Mike Hoare; M Susana Levy; Daniel G Bracewell; Steven D Doig; Simyee Kong; Nigel J Titchener-Hooker; John M Ward; Peter Dunnill
Bioprocess engineering issues that would be faced in producing a DNA vaccine at up to 100 m3 fermentation scale for an influenza pandemic.
Biotechnology progress 2005;21(6):1577-92.
2005: Roeb García-Arrazola; Pierre Dawson; Ian Buchanan; Billy Doyle; Tom Fearn; Nigel J Titchener-Hooker; Frank Baganz
Evaluation of the effects and interactions of mixing and oxygen transfer on the production of Fab' antibody fragments in Escherichia coli fermentation with gas blending.
Bioprocess and biosystems engineering 2005;27(6):365-74.
2005: Kais Lakhdar; Yuhong Zhou; James Savery; Nigel J Titchener-Hooker; Lazaros G Papageorgiou
Medium term planning of biopharmaceutical manufacture using mathematical programming.
Biotechnology progress 2005;21(5):1478-89.
2005: Ai Chye Lim; Yuhong Zhou; John Washbrook; Andrew Sinclair; Brendan Fish; Richard Francis; Nigel J Titchener-Hooker; Suzanne S Farid
Application of a decision-support tool to assess pooling strategies in perfusion culture processes under uncertainty.
Biotechnology progress 2005;21(4):1231-42.
2005: Suzanne S Farid; John Washbrook; Nigel J Titchener-Hooker
Combining multiple quantitative and qualitative goals when assessing biomanufacturing strategies under uncertainty.
Biotechnology progress 2005;21(4):1183-91.
2005: Suzanne S Farid; John Washbrook; Nigel J Titchener-Hooker
Decision-support tool for assessing biomanufacturing strategies under uncertainty: stainless steel versus disposable equipment for clinical trial material preparation.
Biotechnology progress 2005;21(2):486-97.
2005: Anthony J Nealon; Karen E Willson; Samuel C R Pickering; Tim M Clayton; Ronan O'Kennedy; Nigel J Titchener-Hooker; Gary J Lye
Use of operating windows in the assessment of integrated robotic systems for the measurement of bioprocess kinetics.
Biotechnology progress 2005;21(1):283-91.
2004: Nik Willoughby; Phillip Martin; Nigel J Titchener-Hooker
Extreme scale-down of expanded bed adsorption: Purification of an antibody fragment directly from recombinant E. coli culture.
Biotechnology and bioengineering 2004;87(5):641-7.
2004: P J Gardner; Nik Willoughby; R Hjorth; K Lacki; Nigel J Titchener-Hooker
Use of dimensionless residence time to study variations in breakthrough behaviour in expanded beds formed from varied particle size distributions.
Biotechnology and bioengineering 2004;87(3):347-53.
2004: F J Meacle; Russel J Lander; P Ayazi Shamlou; Nigel J Titchener-Hooker
Impact of engineering flow conditions on plasmid DNA yield and purity in chemical cell lysis operations.
Biotechnology and bioengineering 2004;87(3):293-302.
2004: Mustafa A Mustafa; John Washbrook; Ai Chye Lim; Yuhong Zhou; Nigel J Titchener-Hooker; Philip Morton; Steve Berezenko; Suzanne S Farid
A software tool to assist business-process decision-making in the biopharmaceutical industry.
Biotechnology progress 2004;20(4):1096-102.
2004: Martin E Pate; Michael K Turner; Nina F Thornhill; Nigel J Titchener-Hooker
Principal component analysis of nonlinear chromatography.
Biotechnology progress 2004;20(1):215-22.
2003: Y H Zhou; Nigel J Titchener-Hooker
The application of a Pareto optimisation method in the design of an integrated bioprocess.
Bioprocess and biosystems engineering 2003;25(6):349-55.
2003: Sheau-Huey Ngiam; Daniel G Bracewell; Yuhong Zhou; Nigel J Titchener-Hooker
Quantifying process tradeoffs in the operation of chromatographic sequences.
Biotechnology progress 2003;19(4):1315-22.
2002: M P Smith; MA Bulmer; R Hjorth; Nigel J Titchener-Hooker
Hydrophobic interaction ligand selection and scale-up of an expanded bed separation of an intracellular enzyme from Saccharomyces cerevisiae.
Journal of chromatography. A 2002;968(1-2):121-8.
2002: Laura A S Ciccolini; Parviz Ayazi Shamlou; Nigel J Titchener-Hooker
A mass balance study to assess the extent of contaminant removal achieved in the operations for the primary recovery of plasmid DNA from Escherichia coli cells.
Biotechnology and bioengineering 2002;77(7):796-805.
2002: G Bou-Habib; K Yeung; Nigel J Titchener-Hooker; Mike Hoare
Use of at-line spectrophotometry for the rapid definition of pilot-scale flocculation processes.
Biotechnology progress 2002;18(2):387-93.
2001: Sheau-Huey Ngiam; Y H Zhou; Michael K Turner; Nigel J Titchener-Hooker
Graphical method for the calculation of chromatographic performance in representing the trade-off between purity and recovery.
Journal of chromatography. A 2001;937(1-2):1-11.
2001: J L Novais; Nigel J Titchener-Hooker; Mike Hoare
Economic comparison between conventional and disposables-based technology for the production of biopharmaceuticals.
Biotechnology and bioengineering 2001;75(2):143-53.
2001: E G Varga; Nigel J Titchener-Hooker; Peter Dunnill
Prediction of the pilot-scale recovery of a recombinant yeast enzyme using integrated models.
Biotechnology and bioengineering 2001;74(2):96-107.
2000: Nik Willoughby; G Habib; Mike Hoare; R Hjorth; Nigel J Titchener-Hooker
The use of rapid on-line monitoring of products and contaminants from within an expanded bed to control separations exhibiting fast breakthrough characteristics and to maximize productivity.
Biotechnology and bioengineering 2000;70(3):254-61.
2000: Nik Willoughby; R Hjorth; Nigel J Titchener-Hooker
Experimental measurement of particle size distribution and voidage in an expanded bed adsorption system.
Biotechnology and bioengineering 2000;69(6):648-53.
2000: Suzanne S Farid; J L Novais; S Karri; John Washbrook; Nigel J Titchener-Hooker
A tool for modeling strategic decisions in cell culture manufacturing.
Biotechnology progress 2000;16(5):829-36.
2000: Sophia Tsoka; O C Ciniawskyj; O R Thomas; Nigel J Titchener-Hooker; Mike Hoare
Selective flocculation and precipitation for the improvement of virus-like particle recovery from yeast homogenate.
Biotechnology progress 2000;16(4):661-7.
1999: Y H Zhou; Nigel J Titchener-Hooker
Visualizing integrated bioprocess designs through "windows of operation".
Biotechnology and bioengineering 1999;65(5):550-7.
1999: Nik Willoughby; T Kirschner; M P Smith; R Hjorth; Nigel J Titchener-Hooker
Immobilised metal ion affinity chromatography purification of alcohol dehydrogenase from baker's yeast using an expanded bed adsorption system.
Journal of chromatography. A 1999;840(2):195-204.
1998: L A Ciccolini; Parviz Ayazi Shamlou; Nigel J Titchener-Hooker; John M Ward; Peter Dunnill
Time course of SDS-alkaline lysis of recombinant bacterial cells for plasmid release.
Biotechnology and bioengineering 1998;60(6):768-70.
1998: Parviz Ayazi Shamlou; Peter Dunnill; Mike Hoare; AP Ison; Eli Keshavarz-Moore; Gary J Lye; Nigel J Titchener-Hooker; Michael K Turner; John M Woodley; Barry Buckland
UCL biochemical engineering.
Biotechnology and bioengineering 1998;60(5):527-33.
1997: S F Siddiqi; Nigel J Titchener-Hooker; Parviz Ayazi Shamlou
High pressure disruption of yeast cells: The use of scale down operations for the prediction of protein release and cell debris size distribution.
Biotechnology and bioengineering 1997;55(4):642-9.
1996: S F Siddiqi; Nigel J Titchener-Hooker; Parviz Ayazi Shamlou
Simulation of particle size distribution changes occurring during high-pressure disruption of bakers' yeast.
Biotechnology and bioengineering 1996;50(2):145-50.
1994: Nigel J Titchener-Hooker
European biochemical engineering at its best.
Trends in biotechnology 1994;12(9):337-8.
1993: A I Clarkson; P Lefevre; Nigel J Titchener-Hooker
A study of process interactions between cell disruption and debris clarification stages in the recovery of yeast intracellular products.
Biotechnology progress 1993;9(5):462-7.