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Richard Titus

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J Santiago Mejia; Amanda L Toot-Zimmer; Patricia C Schultheiss; Barry J Beaty; Richard G Titus
BluePort: a platform to study the eosinophilic response of mice to the bite of a vector of Leishmania parasites, Lutzomyia longipalpis sand flies.
J Santiago Mejia; Erik N Arthun; Richard G Titus
Cysteine-free proteins in the immunobiology of arthropod-borne diseases.
William H Wheat; Kristen E Pauken; Robin V Morris; Richard G Titus
Lutzomyia longipalpis salivary peptide maxadilan alters murine dendritic cell expression of CD80/86, CCR7, and cytokine secretion and reprograms dendritic cell-mediated cytokine release from cultures containing allogeneic T cells.

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2010: J Santiago Mejia; Amanda L Toot-Zimmer; Patricia C Schultheiss; Barry J Beaty; Richard G Titus
BluePort: a platform to study the eosinophilic response of mice to the bite of a vector of Leishmania parasites, Lutzomyia longipalpis sand flies.
PloS one 2010;5(10):e13546.
2010: J Santiago Mejia; Erik N Arthun; Richard G Titus
Cysteine-free proteins in the immunobiology of arthropod-borne diseases.
Journal of biomedicine & biotechnology 2010;2010():171537.
2008: William H Wheat; Kristen E Pauken; Robin V Morris; Richard G Titus
Lutzomyia longipalpis salivary peptide maxadilan alters murine dendritic cell expression of CD80/86, CCR7, and cytokine secretion and reprograms dendritic cell-mediated cytokine release from cultures containing allogeneic T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(12):8286-98.
2007: Mohammad A Al-Wabel; Willy K Tonui; Liwang Cui; Samuel K Martin; Richard G Titus
Protection of susceptible BALB/c mice from challenge with Leishmania major by nucleoside hydrolase, a soluble exo-antigen of Leishmania.
The American journal of tropical medicine and hygiene 2007;77(6):1060-5.
2007: Rosaly Vieira dos Santos; Richard G Titus; Hermenio Lima
Objective evaluation of skin prick test reactions using digital photography.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2007;13(2):148-53.
2007: Tess M Brodie; Matthew C Smith; Robin V Morris; Richard G Titus
Immunomodulatory effects of the Lutzomyia longipalpis salivary gland protein maxadilan on mouse macrophages.
Infection and immunity 2007;75(5):2359-65.
2007: Willy K Tonui; Richard G Titus
Cross-protection against Leishmania donovani but not L. Braziliensis caused by vaccination with L. Major soluble promastigote exogenous antigens in BALB/c mice.
The American journal of tropical medicine and hygiene 2007;76(3):579-84.
2007: Marta Chagas Monteiro; Hermenio Lima; Adelson A Almeida Souza; Richard G Titus; Pedro R T Romão; Fernando Q Cunha
Effect of Lutzomyia longipalpis salivary gland extracts on leukocyte migration induced by Leishmania major.
The American journal of tropical medicine and hygiene 2007;76(1):88-94.
2006: Owen J Bowers; Kirsa B Sommersted; Ryan T Sowell; Gretchen E Boling; William H Hanneman; Richard G Titus; Gregory DeKrey
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) reduces Leishmania major burdens in C57BL/6 mice.
The American journal of tropical medicine and hygiene 2006;75(4):749-52.
2006: Jeanette V Bishop; J Santiago Mejia; Adalberto A Pérez De León; Walter J Tabachnick; Richard G Titus
Salivary gland extracts of Culicoides sonorensis inhibit murine lymphocyte proliferation and no production by macrophages.
The American journal of tropical medicine and hygiene 2006;75(3):532-6.
2006: J Santiago Mejia; Jeanette V Bishop; Richard G Titus
Is it possible to develop pan-arthropod vaccines?
Trends in parasitology 2006;22(8):367-70.
2006: Keith G Nelson; Jeanette V Bishop; Robert O Ryan; Richard G Titus
Nanodisk-associated amphotericin B clears Leishmania major cutaneous infection in susceptible BALB/c mice.
Antimicrobial agents and chemotherapy 2006;50(4):1238-44.
2006: Richard G Titus; Jeanette V Bishop; J Santiago Mejia
The immunomodulatory factors of arthropod saliva and the potential for these factors to serve as vaccine targets to prevent pathogen transmission.
Parasite immunology 2006;28(4):131-41.
2006: Stephanie St George; Jeanette V Bishop; Richard G Titus; Claude P Selitrennikoff
Novel compounds active against Leishmania major.
Antimicrobial agents and chemotherapy 2006;50(2):474-9.
2004: Kathleen A Rogers; Richard G Titus
Characterization of the early cellular immune response to Leishmania major using peripheral blood mononuclear cells from Leishmania-naive humans.
The American journal of tropical medicine and hygiene 2004;71(5):568-76.
2004: J Santiago Mejia; Fernando Moreno; Carlos E Muskus; Iván Darío Vélez; Richard G Titus
The surface-mosaic model in host-parasite relationships.
Trends in parasitology 2004;20(11):508-11.
2004: Willy K Tonui; J Santiago Mejia; Lisa Hochberg; Lamine Mbow; Jeffrey R Ryan; Adeline S T Chan; Samuel K Martin; Richard G Titus
Immunization with Leishmania major exogenous antigens protects susceptible BALB/c mice against challenge infection with L. major.
Infection and immunity 2004;72(10):5654-61.
2004: Cynthia M Theodos; Robin V Morris; Jeanette V Bishop; Jeremy D Jones; W Robert McMaster; Richard G Titus
Characterization of an I-E-restricted, gp63-specific, CD4-T-cell clone from Leishmania major-resistant C3H mice that secretes type 2 cytokines and exacerbates infection with L. major.
Infection and immunity 2004;72(8):4486-93.
2004: Kathleen A Rogers; Richard G Titus
The human cytokine response to Leishmania major early after exposure to the parasite in vitro.
The Journal of parasitology 2004;90(3):557-63.
2004: Dirceu J Costa; Cecília Favali; Jorge Clarencio; Lílian Afonso; Viviane Conceição; José C Miranda; Richard G Titus; Jesus Valenzuela; Manoel Barral-Netto; Aldina Barral; Cláudia Brodskyn
Lutzomyia longipalpis salivary gland homogenate impairs cytokine production and costimulatory molecule expression on human monocytes and dendritic cells.
Infection and immunity 2004;72(3):1298-305.
2003: Gregory DeKrey; Jeremy J Jones; Lamine Mbow; Cláudia Brodskyn; Richard G Titus
Short report: requirement of b cells for delayed type hypersensitivity-like pathology after secondary infection with Leishmania major in resistant C57BL/6 mice.
The American journal of tropical medicine and hygiene 2003;69(5):481-3.
2003: Kathleen A Rogers; Richard G Titus
Immunomodulatory effects of Maxadilan and Phlebotomus papatasi sand fly salivary gland lysates on human primary in vitro immune responses.
Parasite immunology 2003;25(3):127-34.
2003: V O Guilpin; L Nosbisch; Richard G Titus; Christine J Swardson-Olver
Infection with Leishmania major stimulates haematopoiesis in susceptible BALB/c mice and suppresses haematopoiesis in resistant CBA mice.
Parasitology 2003;126(Pt 3):187-94.
2002: Valerie O Guilpin; Christine J Swardson-Olver; Leanna Nosbisch; Richard G Titus
Maxadilan, the vasodilator/immunomodulator from Lutzomyia longipalpis sand fly saliva, stimulates haematopoiesis in mice.
Parasite immunology 2002;24(8):437-46.
2002: Kathleen A Rogers; Gregory DeKrey; Lamine Mbow; R Dean Gillespie; Cláudia Brodskyn; Richard G Titus
Type 1 and type 2 responses to Leishmania major.
FEMS microbiology letters 2002;209(1):1-7.
2001: Robin V Morris; Charles B Shoemaker; John R David; Gregory C Lanzaro; Richard G Titus
Sandfly maxadilan exacerbates infection with Leishmania major and vaccinating against it protects against L. major infection.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):5226-30.
2001: Richard G Titus; Gregory DeKrey; Robin V Morris; M B Soares
Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease.
Infection and immunity 2001;69(8):5189-92.
2001: Lamine Mbow; Gregory DeKrey; Richard G Titus
Leishmania major induces differential expression of costimulatory molecules on mouse epidermal cells.
European journal of immunology 2001;31(5):1400-9.
2001: R Dean Gillespie; Marc C Dolan; Joseph Piesman; Richard G Titus
Identification of an IL-2 binding protein in the saliva of the Lyme disease vector tick, Ixodes scapularis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4319-26.
2001: Lamine Mbow; Nordin S Zeidner; Robert D Gilmore; M Dolan; Joseph Piesman; Richard G Titus
Major histocompatibility complex class II-independent generation of neutralizing antibodies against T-cell-dependent Borrelia burgdorferi antigens presented by dendritic cells: regulation by NK and gammadelta T cells.
Infection and immunity 2001;69(4):2407-15.
2001: Cláudia Brodskyn; Gregory DeKrey; Richard G Titus
Influence of costimulatory molecules on immune response to Leishmania major by human cells in vitro.
Infection and immunity 2001;69(2):665-72.
2000: R Dean Gillespie; Lamine Mbow; Richard G Titus
The immunomodulatory factors of bloodfeeding arthropod saliva.
Parasite immunology 2000;22(7):319-31.
2000: H R Chakkalath; A A Siddiqui; A H Shankar; Deborah E Dobson; Stephen M Beverley; Richard G Titus
Priming of a beta-galactosidase (beta-GAL)-specific type 1 response in BALB/c mice infected with beta-GAL-transfected Leishmania major.
Infection and immunity 2000;68(2):809-14.
2000: Cláudia Brodskyn; S M Beverley; Richard G Titus
Virulent or avirulent (dhfr-ts-) Leishmania major elicit predominantly a type-1 cytokine response by human cells in vitro.
Clinical and experimental immunology 2000;119(2):299-304.
1999: Lamine Mbow; Robert D Gilmore; Richard G Titus
An OspC-specific monoclonal antibody passively protects mice from tick-transmitted infection by Borrelia burgdorferi B31.
Infection and immunity 1999;67(10):5470-2.
1999: Gregory DeKrey; Richard G Titus
A method for the isolation and analysis of leucocytic cells from Leishmanial ear lesions in mice.
Journal of immunological methods 1999;228(1-2):1-11.
1999: Gregory C Lanzaro; A H Lopes; J M Ribeiro; Charles B Shoemaker; Alon Warburg; M Soares; Richard G Titus
Variation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex.
Insect molecular biology 1999;8(2):267-75.
1999: L A De Freitas; L M Mbow; M Estay; JA Bleyenberg; Richard G Titus
Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.
Parasite immunology 1999;21(5):273-7.
1999: Hermenio Lima; Gregory DeKrey; Richard G Titus
Resolution of an infection with Leishmania braziliensis confers complete protection to a subsequent challenge with Leishmania major in BALB/c mice.
Memórias do Instituto Oswaldo Cruz 1999;94(1):71-6.
1998: Lamine Mbow; JA Bleyenberg; L R Hall; Richard G Titus
Phlebotomus papatasi sand fly salivary gland lysate down-regulates a Th1, but up-regulates a Th2, response in mice infected with Leishmania major.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5571-7.
1998: Marcelo T Bozza; M B Soares; Patrícia T Bozza; Abhay R Satoskar; T G Diacovo; F Brombacher; Richard G Titus; Charles B Shoemaker; John R David
The PACAP-type I receptor agonist maxadilan from sand fly saliva protects mice against lethal endotoxemia by a mechanism partially dependent on IL-10.
European journal of immunology 1998;28(10):3120-7.
1998: Richard G Titus
Salivary gland lysate from the sand fly Lutzomyia longipalpis suppresses the immune response of mice to sheep red blood cells in vivo and concanavalin A in vitro.
Experimental parasitology 1998;89(1):133-6.
1998: M B Soares; Richard G Titus; Charles B Shoemaker; John R David; Marcelo T Bozza
The vasoactive peptide maxadilan from sand fly saliva inhibits TNF-alpha and induces IL-6 by mouse macrophages through interaction with the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(4):1811-6.
1998: K B Donnelly; Hermenio Lima; Richard G Titus
Histologic characterization of experimental cutaneous leishmaniasis in mice infected with Leishmania braziliensis in the presence or absence of sand fly vector salivary gland lysate.
The Journal of parasitology 1998;84(1):97-103.
1998: Gregory DeKrey; Hermenio Lima; Richard G Titus
Analysis of the immune responses of mice to infection with Leishmania braziliensis.
Infection and immunity 1998;66(2):827-9.
1997: Lamine Mbow; Nordin S Zeidner; Nicholas A Panella; Richard G Titus; Joseph Piesman
Borrelia burgdorferi-pulsed dendritic cells induce a protective immune response against tick-transmitted spirochetes.
Infection and immunity 1997;65(8):3386-90.
1997: M B Soares; John R David; Richard G Titus
An in vitro model for infection with Leishmania major that mimics the immune response in mice.
Infection and immunity 1997;65(7):2837-45.
1997: Hermenio Lima; JA Bleyenberg; Richard G Titus
A simple method for quantifying Leishmania in tissues of infected animals.
Parasitology today (Personal ed.) 1997;13(2):80-2.
1997: A H Shankar; Richard G Titus
The influence of antigen-presenting cell type and interferon-gamma on priming and cytokine secretion of Leishmania major-specific T cells.
The Journal of infectious diseases 1997;175(1):151-7.
1996: Hermenio Lima; Richard G Titus
Effects of sand fly vector saliva on development of cutaneous lesions and the immune response to Leishmania braziliensis in BALB/c mice.
Infection and immunity 1996;64(12):5442-5.
1996: J A Brown; Richard G Titus; N Nabavi; Laurie H Glimcher
Blockade of CD86 ameliorates Leishmania major infection by down-regulating the Th2 response.
The Journal of infectious diseases 1996;174(6):1303-8.
1996: A H Shankar; P Morin; Richard G Titus
Leishmania major: differential resistance to infection in C57BL/6 (high interferon-alpha/beta) and congenic B6.C-H-28c (low interferon-alpha/beta) mice.
Experimental parasitology 1996;84(2):136-43.
1995: Richard G Titus; F J Gueiros-Filho; L A de Freitas; Stephen M Beverley
Development of a safe live Leishmania vaccine line by gene replacement.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10267-71.
1995: L R Hall; Richard G Titus
Sand fly vector saliva selectively modulates macrophage functions that inhibit killing of Leishmania major and nitric oxide production.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(7):3501-6.
1995: H R Chakkalath; C M Theodos; J S Markowitz; Michael J Grusby; Laurie H Glimcher; Richard G Titus
Class II major histocompatibility complex-deficient mice initially control an infection with Leishmania major but succumb to the disease.
The Journal of infectious diseases 1995;171(5):1302-8.
1995: A H Shankar; Richard G Titus
T cell and non-T cell compartments can independently determine resistance to Leishmania major.
The Journal of experimental medicine 1995;181(3):845-55.
1994: H R Chakkalath; Richard G Titus
Leishmania major-parasitized macrophages augment Th2-type T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(10):4378-87.
1994: C M Theodos; A Shankar; Andrew Glasebrook; W D Roeder; Richard G Titus
The effect of treating with anti-interleukin-1 receptor antibody on the course of experimental murine cutaneous leishmaniasis.
Parasite immunology 1994;16(11):571-7.
1994: S Urioste; L R Hall; S R Telford; Richard G Titus
Saliva of the Lyme disease vector, Ixodes dammini, blocks cell activation by a nonprostaglandin E2-dependent mechanism.
The Journal of experimental medicine 1994;180(3):1077-85.
1994: Alon Warburg; E Saraiva; Gregory C Lanzaro; Richard G Titus; F Neva
Saliva of Lutzomyia longipalpis sibling species differs in its composition and capacity to enhance leishmaniasis.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1994;345(1312):223-30.
1994: BK Wershil; C M Theodos; Stephen J Galli; Richard G Titus
Mast cells augment lesion size and persistence during experimental Leishmania major infection in the mouse.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(9):4563-71.
1994: Richard G Titus; C M Theodos; A H Shankar; L R Hall
Interactions between Leishmania major and macrophages.
Immunology series 1994;60():437-59.
1993: P B Kimsey; C M Theodos; T K Mitchen; S J Turco; Richard G Titus
An avirulent lipophosphoglycan-deficient Leishmania major clone induces CD4+ T cells which protect susceptible BALB/c mice against infection with virulent L. major.
Infection and immunity 1993;61(12):5205-13.
1993: A Shankar; T K Mitchen; L R Hall; S J Turco; Richard G Titus
Reversion to virulence in Leishmania major correlates with expression of surface lipophosphoglycan.
Molecular and biochemical parasitology 1993;61(2):207-16.
1993: C M Theodos; Richard G Titus
Salivary gland material from the sand fly Lutzomyia longipalpis has an inhibitory effect on macrophage function in vitro.
Parasite immunology 1993;15(8):481-7.
1993: A H Shankar; Richard G Titus
Leishmania major-specific, CD4+, major histocompatibility complex class II-restricted T cells derived in vitro from lymphoid tissues of naive mice.
The Journal of experimental medicine 1993;178(1):101-11.
1992: Anne E Goldfeld; EK Flemington; Vassiliki A Boussiotis; C M Theodos; Richard G Titus; Jack L Strominger; Samuel H Speck
Transcription of the tumor necrosis factor alpha gene is rapidly induced by anti-immunoglobulin and blocked by cyclosporin A and FK506 in human B cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(24):12198-201.
1992: Richard G Titus; C M Theodos; P B Kimsey; A Shankar; L Hall; M McGurn; L Povinelli
Role of T cells in immunity to the intracellular pathogen, Leishmania major.
Sub-cellular biochemistry 1992;18():99-129.
1991: C M Theodos; L Povinelli; R Molina; B Sherry; Richard G Titus
Role of tumor necrosis factor in macrophage leishmanicidal activity in vitro and resistance to cutaneous leishmaniasis in vivo.
Infection and immunity 1991;59(8):2839-42.
1991: Richard G Titus
Colchicine is a potent adjuvant for eliciting T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(12):4115-9.
1991: C M Theodos; J M Ribeiro; Richard G Titus
Analysis of enhancing effect of sand fly saliva on Leishmania infection in mice.
Infection and immunity 1991;59(5):1592-8.
1991: Richard G Titus; Ingrid Müller; P Kimsey; A Cerny; R Behin; Rolf M Zinkernagel; Jacques A Louis
Exacerbation of experimental murine cutaneous leishmaniasis with CD4+ Leishmania major-specific T cell lines or clones which secrete interferon-gamma and mediate parasite-specific delayed-type hypersensitivity.
European journal of immunology 1991;21(3):559-67.
1991: J Samuelson; E Lerner; R Tesh; Richard G Titus
A mouse model of Leishmania braziliensis braziliensis infection produced by coinjection with sand fly saliva.
The Journal of experimental medicine 1991;173(1):49-54.
1990: M McGurn; T Boon; Jacques A Louis; Richard G Titus
Leishmania major: nature of immunity induced by immunization with a mutagenized avirulent clone of the parasite in mice.
Experimental parasitology 1990;71(1):81-9.
1990: Richard G Titus; J M Ribeiro
The role of vector saliva in transmission of arthropod-borne disease.
Parasitology today (Personal ed.) 1990;6(5):157-60.
1989: Ingrid Müller; Jose A. Garcia-Sanz; Richard G Titus; R Behin; Jacques Louis
Analysis of the cellular parameters of the immune responses contributing to resistance and susceptibility of mice to infection with the intracellular parasite, Leishmania major.
Immunological reviews 1989;112():95-113.
1989: Richard G Titus; B Sherry; A Cerami
Tumor necrosis factor plays a protective role in experimental murine cutaneous leishmaniasis.
The Journal of experimental medicine 1989;170(6):2097-104.
1987: Richard G Titus; Geneviève Milon; G Marchal; P Vassalli; J C Cerottini; Jacques A Louis
Involvement of specific Lyt-2+ T cells in the immunological control of experimentally induced murine cutaneous leishmaniasis.
European journal of immunology 1987;17(10):1429-33.
1987: Jacques A Louis; Thierry Pedrazzini; Richard G Titus; I Muller; Jay P Farrell; V Kindler; P Vassalli; G Marchal; Geneviève Milon
Subsets of specific T cells and experimental cutaneous leishmaniasis.
Annales de l'Institut Pasteur. Immunology 1987;138(5):755-8.