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Lars Tjernberg

Research Profile

Chemicals & Drugs

Disorders

Alzheimer's Disease

Genes & Molecular Sequences

Amino Acid Sequences

Concepts & Ideas

Anatomy

Brain

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Microscopy, Electron

Living Beings

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Publications

TOP 3
Anna Sandebring; Hedvig Welander; Bengt Winblad; Caroline Graff; Lars O Tjernberg
The pathogenic aβ43 is enriched in familial and sporadic Alzheimer disease.
Yasuhiro Teranishi; Bengt Winblad; Homira Behbahani; Susanne Frykman; Gucci Jijuan Gu; Ji-Yeun Hur; Taizo Ishikawa; Masood Kamali-Moghaddam; Takahiro Kihara; Takeshi Nishimura; Lars O Tjernberg
Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production.
Masakazu Hashimoto; Hiroyuki Nakagawa; Jun Sakai; Mikio Aoki; Nenad Bogdanovic; Inga Volkmann; Bengt Winblad; Lars O Tjernberg
Analysis of microdissected neurons by 18O mass spectrometry reveals altered protein expression in Alzheimer's disease.

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All Publications

2013: Anna Sandebring; Hedvig Welander; Bengt Winblad; Caroline Graff; Lars O Tjernberg
The pathogenic aβ43 is enriched in familial and sporadic Alzheimer disease.
PloS one 2013;8(2):e55847.
2012: Yasuhiro Teranishi; Bengt Winblad; Homira Behbahani; Susanne Frykman; Gucci Jijuan Gu; Ji-Yeun Hur; Taizo Ishikawa; Masood Kamali-Moghaddam; Takahiro Kihara; Takeshi Nishimura; Lars O Tjernberg
Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production.
Biochemical and biophysical research communications 2012;424(3):476-81.
2012: Masakazu Hashimoto; Hiroyuki Nakagawa; Jun Sakai; Mikio Aoki; Nenad Bogdanovic; Inga Volkmann; Bengt Winblad; Lars O Tjernberg
Analysis of microdissected neurons by 18O mass spectrometry reveals altered protein expression in Alzheimer's disease.
Journal of cellular and molecular medicine 2012;16(8):1686-700.
2012: Susanne Frykman; Ji-Yeun Hur; Takahiro Kihara; Takeshi Nishimura; Anna Sandebring; Sophia Schedin-Weiss; Yasuhiro Teranishi; Maria Ancarcrona; Nenad Bogdanovic; Bengt Winblad; Natsuko Goto Yamamoto; Lars O Tjernberg
Identification of two novel synaptic γ-secretase associated proteins that affect amyloid β-peptide levels without altering Notch processing.
Neurochemistry international 2012;61(1):108-18.
2012: Ola Philipson; Rabah Soliymani; Johan Thyberg; Lars O Tjernberg; Tommie Olofsson; Marc Baumann; Nenad Bogdanovic; Martin Ingelsson; Hannu Kalimo; Maciej Lalowski; Lars Lannfelt; Anna Lord; Lars N G Nilsson
The Arctic amyloid-β precursor protein (AβPP) mutation results in distinct plaques and accumulation of N- and C-truncated Aβ.
Neurobiology of aging 2012;33(5):1010.e1-13.
2012: Ji-Yeun Hur; Mitsuhiro Inoue; Takahiro Kihara; Yasuhiro Teranishi; Susanne Frykman; Masakazu Hashimoto; Waltteri Hosia; Bengt Winblad; Natsuko Goto Yamamoto; Lars O Tjernberg
Identification of novel γ-secretase-associated proteins in detergent-resistant membranes from brain.
The Journal of biological chemistry 2012;287(15):11991-2005.
2011: Louise Hedskog; Helena Karlström; Camilla A Hansson Petersen; Annelie I Svensson; Lars O Tjernberg; Hedvig Welander; Maria Ankarcrona
γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio.
Journal of cellular and molecular medicine 2011;15(10):2150-63.
2011: Annelie Pamrén; Lars O Tjernberg; Johanna Wanngren; Bengt Winblad; Ratan Bhat; Jan Näslund; Helena Karlström
Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing.
The Journal of biological chemistry 2011;286(36):31153-8.
2010: Lina Keller; Hedvig Welander; Huei-Hsin Chiang; Lars O Tjernberg; Inger Nennesmo; Asa K Wallin; Caroline Graff
The PSEN1 I143T mutation in a Swedish family with Alzheimer's disease: clinical report and quantification of Aβ in different brain regions.
European journal of human genetics : EJHG 2010;18(11):1202-8.
2010: Yasuhiro Teranishi; Ji-Yeun Hur; Hedvig Welander; Jenny Frånberg; Mikio Aoki; Bengt Winblad; Susanne Frykman; Lars O Tjernberg
Affinity pulldown of γ-secretase and associated proteins from human and rat brain.
Journal of cellular and molecular medicine 2010;14(11):2675-86.
2010: Masakazu Hashimoto; Nenad Bogdanovic; Inga Volkmann; Mikio Aoki; Bengt Winblad; Lars O Tjernberg
Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Abeta42 and Alzheimer's disease neuropathology.
Acta neuropathologica 2010;119(5):543-54.
2010: Jenny Frånberg; Helena Karlström; Bengt Winblad; Lars O Tjernberg; Susanne Frykman
gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes.
PloS one 2010;5(3):e9772.
2010: Susanne Frykman; Ji-Yeun Hur; Jenny Frånberg; Mikio Aoki; Bengt Winblad; Jarmila Nahalkova; Homira Behbahani; Lars O Tjernberg
Synaptic and endosomal localization of active gamma-secretase in rat brain.
PloS one 2010;5(1):e8948.
2010: Jarmila Nahalkova; Inga Volkmann; Mikio Aoki; Bengt Winblad; Nenad Bogdanovic; Lars O Tjernberg; Homira Behbahani
CD147, a gamma-secretase associated protein is upregulated in Alzheimer's disease brain and its cellular trafficking is affected by presenilin-2.
Neurochemistry international 2010;56(1):67-76.
2009: Hedvig Welander; Jenny Frånberg; Caroline Graff; Erik Sundström; Bengt Winblad; Lars O Tjernberg
Abeta43 is more frequent than Abeta40 in amyloid plaque cores from Alzheimer disease brains.
Journal of neurochemistry 2009;110(2):697-706.
2008: Mikio Aoki; Inga Volkmann; Lars O Tjernberg; Bengt Winblad; Nenad Bogdanovic
Amyloid beta-peptide levels in laser capture microdissected cornu ammonis 1 pyramidal neurons of Alzheimer's brain.
Neuroreport 2008;19(11):1085-9.
2008: Ji-Yeun Hur; Hedvig Welander; Homira Behbahani; Mikio Aoki; Jenny Frånberg; Bengt Winblad; Susanne Frykman; Lars O Tjernberg
Active gamma-secretase is localized to detergent-resistant membranes in human brain.
The FEBS journal 2008;275(6):1174-87.
2007: Annika Larsson; Linda Söderberg; Gunilla T Westermark; Knut Sletten; Ulla Engström; Lars O Tjernberg; Jan Näslund; Per Westermark
Unwinding fibril formation of medin, the peptide of the most common form of human amyloid.
Biochemical and biophysical research communications 2007;361(4):822-8.
2007: Jenny Frånberg; Hedvig Welander; Mikio Aoki; Bengt Winblad; Lars O Tjernberg; Susanne Frykman
Rat brain gamma-secretase activity is highly influenced by detergents.
Biochemistry 2007;46(25):7647-54.
2006: Annelie Falkevall; Nyosha Alikhani; Shashi Bhushan; Pavel F Pavlov; Katrin Busch; Kenneth Alan Johnson; Therese Eneqvist; Lars O Tjernberg; Maria Ankarcrona; Elzbieta Glaser
Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP.
The Journal of biological chemistry 2006;281(39):29096-104.
2006: Linda Söderberg; Nenad Bogdanovic; Birgitta Axelsson; Bengt Winblad; Jan Näslund; Lars O Tjernberg
Analysis of single Alzheimer solid plaque cores by laser capture microscopy and nanoelectrospray/tandem mass spectrometry.
Biochemistry 2006;45(32):9849-56.
2005: Hiroyoshi Kakuyama; Linda Söderberg; Kazuhiko Horigome; Bengt Winblad; Camilla Dahlqvist; Jan Näslund; Lars O Tjernberg
CLAC binds to aggregated Abeta and Abeta fragments, and attenuates fibril elongation.
Biochemistry 2005;44(47):15602-9.
2005: W Haung Yu; Ana Maria Cuervo; Asok Kumar; Corrinne M Peterhoff; Stephen D Schmidt; Ju-Hyun Lee; Panaiyur S Mohan; Marc Mercken; Mark Farmery; Lars O Tjernberg; Ying Jiang; karen duff; Yasuo Uchiyama; Jan Näslund; Paul Mathews; Anne M Cataldo; Ralph A. Nixon
Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease.
The Journal of cell biology 2005;171(1):87-98.
2005: Linda Söderberg; Camilla Dahlqvist; Hiroyoshi Kakuyama; Johan Thyberg; Akira Ito; Bengt Winblad; Jan Näslund; Lars O Tjernberg
Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates.
The FEBS journal 2005;272(9):2231-6.
2005: Linda Söderberg; Hiroyoshi Kakuyama; Anna Möller; Akira Ito; Bengt Winblad; Lars O Tjernberg; Jan Näslund
Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide-binding site.
The Journal of biological chemistry 2005;280(2):1007-15.
2004: Camilla A Hansson; Susanne Frykman; Mark Farmery; Lars O Tjernberg; Camilla Nilsberth; Sharon E Pursglove; Akira Ito; Bengt Winblad; Richard Frank Cowburn; Johan Thyberg; Maria Ankarcrona
Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria.
The Journal of biological chemistry 2004;279(49):51654-60.
2004: Waltteri Hosia; Niklas Bark; Edvards Liepinsh; Agneta Tjernberg; Bengt Persson; Dan Hallén; Johan Thyberg; Jan Johansson; Lars O Tjernberg
Folding into a beta-hairpin can prevent amyloid fibril formation.
Biochemistry 2004;43(16):4655-61.
2003: Mark Farmery; Lars O Tjernberg; Sharon E Pursglove; Anna Bergman; Bengt Winblad; Jan Näslund
Partial purification and characterization of gamma-secretase from post-mortem human brain.
The Journal of biological chemistry 2003;278(27):24277-84.
2003: Lena Lilius; Charlotte Forsell; Karin Axelman; Bengt Winblad; Caroline Graff; Lars O Tjernberg
No association between polymorphisms in the neprilysin promoter region and Swedish Alzheimer's disease patients.
Neuroscience letters 2003;337(2):111-3.
2002: Lars O Tjernberg; Waltteri Hosia; Niklas Bark; Johan Thyberg; Jan Johansson
Charge attraction and beta propensity are necessary for amyloid fibril formation from tetrapeptides.
The Journal of biological chemistry 2002;277(45):43243-6.
2002: Lars O Tjernberg; Agneta Tjernberg; Niklas Bark; Yuan Shi; Bela P Ruzsicska; Zimei Bu; Johan Thyberg; David J E Callaway
Assembling amyloid fibrils from designed structures containing a significant amyloid beta-peptide fragment.
The Biochemical journal 2002;366(Pt 1):343-51.
2000: Pascal Kuner; Bernd Bohrmann; Lars O Tjernberg; Jan Näslund; G Huber; S Celenk; F Grüninger-Leitch; J Grayson Richards; Roland Jakob-Roetne; John A Kemp; C Nordstedt
Controlling polymerization of beta-amyloid and prion-derived peptides with synthetic small molecule ligands.
The Journal of biological chemistry 2000;275(3):1673-8.
1999: Bo Häggqvist; Jan Näslund; Knut Sletten; Gunilla T Westermark; GI Mucchiano; Lars O Tjernberg; C Nordstedt; Ulla Engström; Per Westermark
Medin: an integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8669-74.
1999: Bernd Bohrmann; Lars O Tjernberg; Pascal Kuner; Sonia Poli; Bernard Levet-Trafit; Jan Näslund; G Richards; Walter Huber; Heinz Döbeli; C Nordstedt
Endogenous proteins controlling amyloid beta-peptide polymerization. Possible implications for beta-amyloid formation in the central nervous system and in peripheral tissues.
The Journal of biological chemistry 1999;274(23):15990-5.
1999: Udo Oppermann; Samina Salim; Lars O Tjernberg; L Terenius; Hans Jörnvall
Binding of amyloid beta-peptide to mitochondrial hydroxyacyl-CoA dehydrogenase (ERAB): regulation of an SDR enzyme activity with implications for apoptosis in Alzheimer's disease.
FEBS letters 1999;451(3):238-42.
1999: Lars O Tjernberg; David J E Callaway; Agneta Tjernberg; S Hahne; C Lilliehöök; Lars Terenius; Johan Thyberg; C Nordstedt
A molecular model of Alzheimer amyloid beta-peptide fibril formation.
The Journal of biological chemistry 1999;274(18):12619-25.
1999: Lars O Tjernberg; Aladdin Pramanik; S Björling; Per Thyberg; Johan Thyberg; C Nordstedt; K D Berndt; Lars Terenius; Rudolf Rigler
Amyloid beta-peptide polymerization studied using fluorescence correlation spectroscopy.
Chemistry & biology 1999;6(1):53-62.
1997: Lars O Tjernberg; C Lilliehöök; David J E Callaway; Jan Näslund; S Hahne; Johan Thyberg; Lars Terenius; C Nordstedt
Controlling amyloid beta-peptide fibril formation with protease-stable ligands.
The Journal of biological chemistry 1997;272(19):12601-5.
1997: Lars O Tjernberg; Jan Näslund; Johan Thyberg; Sam Gandy; Lars Terenius; C Nordstedt
Generation of Alzheimer amyloid beta peptide through nonspecific proteolysis.
The Journal of biological chemistry 1997;272(3):1870-5.
1996: Jan Näslund; A R Karlström; Lars O Tjernberg; A Schierhorn; Lars Terenius; C Nordstedt
High-resolution separation of amyloid beta-peptides: structural variants present in Alzheimer's disease amyloid.
Journal of neurochemistry 1996;67(1):294-301.
1996: Lars O Tjernberg; Jan Näslund; F Lindqvist; J Johansson; A R Karlström; Johan Thyberg; Lars Terenius; C Nordstedt
Arrest of beta-amyloid fibril formation by a pentapeptide ligand.
The Journal of biological chemistry 1996;271(15):8545-8.
1995: C Nordstedt; Jan Näslund; Lars O Tjernberg; A Karlström
[Future drugs against aging? New research on molecular background of aging].
Läkartidningen 1995;92(42):3881-4.
1995: Jan Näslund; Johan Thyberg; Lars O Tjernberg; C Wernstedt; A R Karlström; Nenad Bogdanovic; Sam Gandy; Lars Lannfelt; Lars Terenius; C Nordstedt
Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain.
Neuron 1995;15(1):219-28.
1995: C Nordstedt; Jan Näslund; Lars O Tjernberg; Lars Terenius
[A breakthrough for research on Alzheimer disease. A model for drug testing].
Läkartidningen 1995;92(18):1899-900.
1994: C Nordstedt; Jan Näslund; Lars O Tjernberg; A R Karlström; Johan Thyberg; Lars Terenius
The Alzheimer A beta peptide develops protease resistance in association with its polymerization into fibrils.
The Journal of biological chemistry 1994;269(49):30773-6.
1994: Jan Näslund; M Jensen; Lars O Tjernberg; Johan Thyberg; Lars Terenius; C Nordstedt
The metabolic pathway generating p3, an A beta-peptide fragment, is probably non-amyloidogenic.
Biochemical and biophysical research communications 1994;204(2):780-7.
1994: Jan Näslund; A Schierhorn; U Hellman; Lars Lannfelt; Allen D Roses; Lars O Tjernberg; J Silberring; Sam Gandy; Bengt Winblad; Paul Greengard
Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(18):8378-82.