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Jette Tjørnelund

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Magnetic Resonance Spectroscopy

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Microsomes, Liver

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Brian F Kiesel; Shivaani Kummar; Einars Loza; Robert A Parise; Hussein Tawbi; Jette Tjørnelund; Mette K Christensen; Edward Chu; Jan H Beumer
LC-MS/MS assay for the quantitation of the HDAC inhibitor belinostat and five major metabolites in human plasma.
Mette K Christensen; Kamille D Erichsen; Christina Trojel-Hansen; Jette Tjørnelund; Søren J Nielsen; Karla Frydenvang; Tommy N Johansen; Birgitte Nielsen; Maxwell Sehested; Peter B Jensen; Martins Ikaunieks; Andrei Zaichenko; Einars Loza; Ivars Kalvinsh; Fredrik Björkling
Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-dihydroindole-2-ones.
Aimable Nahimana; Antoine Attinger; Dominique Aubry; Peter Greaney; Christopher Ireson; Annemette V Thougaard; Jette Tjørnelund; Keith M Dawson; Marc Dupuis; Michel A Duchosal
The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies.

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All Publications

2013: Brian F Kiesel; Shivaani Kummar; Einars Loza; Robert A Parise; Hussein Tawbi; Jette Tjørnelund; Mette K Christensen; Edward Chu; Jan H Beumer
LC-MS/MS assay for the quantitation of the HDAC inhibitor belinostat and five major metabolites in human plasma.
Journal of pharmaceutical and biomedical analysis 2013;81-82():89-98.
2010: Mette K Christensen; Kamille D Erichsen; Christina Trojel-Hansen; Jette Tjørnelund; Søren J Nielsen; Karla Frydenvang; Tommy N Johansen; Birgitte Nielsen; Maxwell Sehested; Peter B Jensen; Martins Ikaunieks; Andrei Zaichenko; Einars Loza; Ivars Kalvinsh; Fredrik Björkling
Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-dihydroindole-2-ones.
Journal of medicinal chemistry 2010;53(19):7140-5.
2009: Aimable Nahimana; Antoine Attinger; Dominique Aubry; Peter Greaney; Christopher Ireson; Annemette V Thougaard; Jette Tjørnelund; Keith M Dawson; Marc Dupuis; Michel A Duchosal
The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies.
Blood 2009;113(14):3276-86.
2008: Katherine E Warren; Cynthia McCully; Henrik Dvinge; Jette Tjørnelund; Maxwell Sehested; Henri S Lichenstein; FRANK BALIS
Plasma and cerebrospinal fluid pharmacokinetics of the histone deacetylase inhibitor, belinostat (PXD101), in non-human primates.
Cancer chemotherapy and pharmacology 2008;62(3):433-7.
2008: Nicola L Steele; Jane A Plumb; Laura Vidal; Jette Tjørnelund; Poul Knoblauch; Annie Rasmussen; Chean Eng Ooi; Peter Buhl-Jensen; Robert Brown; T R J Evans; Johann S DeBono
A phase 1 pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(3):804-10.
2008: Marielle Dejligbjerg; Morten Grauslund; Ib Jarle Christensen; Jette Tjørnelund; Peter Buhl Jensen; Maxwell Sehested
Identification of predictive biomarkers for the histone deacetylase inhibitor belinostat in a panel of human cancer cell lines.
Cancer biomarkers : section A of Disease markers 2008;4(2):101-9.
2004: Anne Kruse Lykkeberg; Gitte Sengeløv; Claus Cornett; Jette Tjørnelund; Steen H Hansen; Bent Halling-Sørensen
Isolation, structural elucidation and in vitro activity of 2-acetyl-2-decarboxamido-oxytetracycline against environmental relevant bacteria, including tetracycline-resistant bacteria.
Journal of pharmaceutical and biomedical analysis 2004;34(3):559-67.
2004: Anne Kruse Lykkeberg; Bent Halling-Sørensen; Claus Cornett; Jette Tjørnelund; Steen Honoré Hansen
Quantitative analysis of oxytetracycline and its impurities by LC-MS-MS.
Journal of pharmaceutical and biomedical analysis 2004;34(2):325-32.
2003: Bent Halling-Sørensen; Anne Kruse Lykkeberg; Flemming Ingerslev; Paul A Blackwell; Jette Tjørnelund
Characterisation of the abiotic degradation pathways of oxytetracyclines in soil interstitial water using LC-MS-MS.
Chemosphere 2003;50(10):1331-42.
2003: Jørgen Olsen; Inga Bjørnsdottir; Jette Tjørnelund; Steen Honoré Hansen
Identification of the amino acids of human serum albumin involved in the reaction with the naproxen acyl coenzyme A thioester using liquid chromatography combined with fluorescence and mass spectrometric detection.
Analytical biochemistry 2003;312(2):148-56.
2003: Marie-Louise Loke; Sonja Jespersen; rob vreeken; Bent Halling-Sørensen; Jette Tjørnelund
Determination of oxytetracycline and its degradation products by high-performance liquid chromatography-tandem mass spectrometry in manure-containing anaerobic test systems.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;783(1):11-23.
2002: N Hagen; A K Olsen; J V Andersen; Jette Tjørnelund; Steen H Hansen
Characterization of mixtures of recombinant human cytochrome p450s as a screening model for metabolic stability in drug discovery.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(9):749-59.
2002: Marie-Louise Loke; Jette Tjørnelund; Bent Halling-Sørensen
Determination of the distribution coefficient (log Kd) of oxytetracycline, tylosin A, olaquindox and metronidazole in manure.
Chemosphere 2002;48(3):351-61.
2002: Jørgen Olsen; Inga Bjørnsdottir; Jette Tjørnelund; Steen Honoré Hansen
Chemical reactivity of the naproxen acyl glucuronide and the naproxen coenzyme A thioester towards bionucleophiles.
Journal of pharmaceutical and biomedical analysis 2002;29(1-2):7-15.
2002: Rasmus Worm Mortensen; Ulla G Sidelmann; Jette Tjørnelund; Steen H Hansen
Stereospecific pH-dependent degradation kinetics of R- and S-naproxen-beta-l-O-acyl-glucuronide.
Chirality 2002;14(4):305-12.
2002: Bent Halling-Sørensen; Gitte Sengeløv; Jette Tjørnelund
Toxicity of tetracyclines and tetracycline degradation products to environmentally relevant bacteria, including selected tetracycline-resistant bacteria.
Archives of environmental contamination and toxicology 2002;42(3):263-71.
2002: Rikke Brix; Steen H Hansen; Vicki Barwick; Jette Tjørnelund
Method optimisation with the use of uncertainty budgets.
The Analyst 2002;127(1):140-3.
2000: Marie-Louise Loke; Flemming Ingerslev; Bent Halling-Sørensen; Jette Tjørnelund
Stability of Tylosin A in manure containing test systems determined by high performance liquid chromatography.
Chemosphere 2000;40(7):759-65.
1999: Jette Tjørnelund; Steen H Hansen
Non-aqueous capillary electrophoresis of drugs: properties and application of selected solvents.
Journal of biochemical and biophysical methods 1999;38(2):139-53.
1998: Inga Bjørnsdottir; Jette Tjørnelund; Steen H Hansen
Nonaqueous capillary electrophoresis--its applicability in the analysis of food, pharmaceuticals and biological fluids.
Electrophoresis 1998;19(12):2179-86.
1998: Inga Bjørnsdottir; DR Kepp; Jette Tjørnelund; Steen H Hansen
Separation of the enantiomers of ibuprofen and its major phase I metabolites in urine using capillary electrophoresis.
Electrophoresis 1998;19(3):455-60.
1997: DR Kepp; Ulla G Sidelmann; Jette Tjørnelund; Steen H Hansen
Simultaneous quantitative determination of the major phase I and II metabolites of ibuprofen in biological fluids by high-performance liquid chromatography on dynamically modified silica.
Journal of chromatography. B, Biomedical sciences and applications 1997;696(2):235-41.
1997: L Nadelmann; Jette Tjørnelund; E Christensen; Steen H Hansen
High-performance liquid chromatographic determination of licochalcone A and its metabolites in biological fluids.
Journal of chromatography. B, Biomedical sciences and applications 1997;695(2):389-400.
1997: L Nadelmann; Jette Tjørnelund; Steen H Hansen; Claus Cornett; Ulla G Sidelmann; U Braumann; E Christensen; S Brøgger Christensen
Synthesis, isolation and identification of glucuronides and mercapturic acids of a novel antiparasitic agent, licochalcone A.
Xenobiotica; the fate of foreign compounds in biological systems 1997;27(7):667-80.
1997: Ulla G Sidelmann; E Christiansen; L Krogh; Claus Cornett; Jette Tjørnelund; Steen H Hansen
Purification and 1H NMR spectroscopic characterization of phase II metabolites of tolfenamic acid.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(6):725-31.
1997: Jette Tjørnelund; Steen H Hansen
Validation of a simple method for the determination of oxytetracycline in ointment by non-aqueous capillary electrophoresis.
Journal of pharmaceutical and biomedical analysis 1997;15(8):1077-82.
1996: Ulla G Sidelmann; Claus Cornett; Jette Tjørnelund; Steen H Hansen
A comparative study of precision cut liver slices, hepatocytes, and liver microsomes from the Wistar rat using metronidazole as a model substance.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(7):709-22.
1996: Inga Bjørnsdottir; Jette Tjørnelund; Steen H Hansen
Nonaqueous capillary electrophoresis in pharmaceutical analysis.
Journal of capillary electrophoresis 1996;3(2):83-7.
1995: Steen H Hansen; Inga Bjørnsdottir; Jette Tjørnelund
Separation of basic drug substances of very similar structure using micellar electrokinetic chromatography.
Journal of pharmaceutical and biomedical analysis 1995;13(4-5):489-95.
1993: J Jensen; Claus Cornett; Carl Erik Olsen; S Bondesen; J Christensen; L A Christensen; Jette Tjørnelund; Steen H Hansen
Identification of oxidation products of 5-aminosalicylic acid in faeces and the study of their formation in vitro.
Biochemical pharmacology 1993;45(6):1201-9.
1991: Jette Tjørnelund; Steen H Hansen
Stability of 5-aminosalicylic acid and its metabolites in plasma at -20 degrees C. Formation of N-beta-D-glucopyranosyl-5-aminosalicylic acid.
Journal of chromatography 1991;570(1):224-8.
1991: Jette Tjørnelund; Steen H Hansen
High-performance liquid chromatographic assay of 5-aminosalicylic acid (5-ASA) and its metabolites N-beta-D-glucopyranosyl-5-ASA, N-acetyl-5-ASA, N-formyl-5-ASA and N-butyryl-5-ASA in biological fluids.
Journal of chromatography 1991;570(1):109-17.
1991: Jette Tjørnelund; Steen H Hansen; Claus Cornett
New metabolites of the drug 5-aminosalicylic acid. II. N-formyl-5-aminosalicylic acid.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(5):605-12.
1990: Jette Tjørnelund; Steen H Hansen
Gas chromatographic assay for N,N-dimethylglycine in urine.
Journal of chromatography 1990;530(2):227-34.
1989: Jette Tjørnelund; Steen H Hansen; Claus Cornett
New metabolites of the drug 5-aminosalicylic acid. I: N-beta-D-glucopyranosyl-5-aminosalicylic acid.
Xenobiotica; the fate of foreign compounds in biological systems 1989;19(8):891-9.