FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Kazuyuki Tobe

Research Profile

Chemicals & Drugs

Disorders

Living Beings

Phenomena

Phosphorylation

Physiology

Co-author Network

Publications

TOP 3
Hayato Fujita; Kazuo Hara; Yushi Hirota; Momoko Horikoshi; Minoru Iwata; Susumu Seino; Nobuhiro Shojima; Kazuyuki Tobe; Takashi Kadowaki
Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits.
Kosei Eguchi; Takashi Kadowaki; Masao Kimoto; Nozomu Kono; Ichiro Manabe; Kensuke Miyake; Fusa Ogata; Miho Ohsugi; Umeharu Ohto; Yumiko Oishi-Tanaka; Kazuyuki Tobe; Nobuhiro Yagi; Hiroyuki Arai; Ryozo Nagai
Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation.
Masumi Hara; Yoshihiko Izumida; Nobuhiro Sato; Ken Ohashi; Jun-ichi Osuga; Kazuyuki Tobe; Kazuhisa Tsukamoto; Takashi Kadowaki
Successful desensitization by glargine administration in a patient with insulin allergy: a case report.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Kazuyuki Tobe (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Hayato Fujita; Kazuo Hara; Yushi Hirota; Momoko Horikoshi; Minoru Iwata; Susumu Seino; Nobuhiro Shojima; Kazuyuki Tobe; Takashi Kadowaki
Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits.
Journal of human genetics 2012;57(12):776-9.
2012: Kosei Eguchi; Takashi Kadowaki; Masao Kimoto; Nozomu Kono; Ichiro Manabe; Kensuke Miyake; Fusa Ogata; Miho Ohsugi; Umeharu Ohto; Yumiko Oishi-Tanaka; Kazuyuki Tobe; Nobuhiro Yagi; Hiroyuki Arai; Ryozo Nagai
Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation.
Cell metabolism 2012;15(4):518-33.
2009: Masumi Hara; Yoshihiko Izumida; Nobuhiro Sato; Ken Ohashi; Jun-ichi Osuga; Kazuyuki Tobe; Kazuhisa Tsukamoto; Takashi Kadowaki
Successful desensitization by glargine administration in a patient with insulin allergy: a case report.
Diabetes research and clinical practice 2009;84(3):e48-9.
2009: Kazutaka Aoki; Junji Matsui; Naoto Kubota; Hiromu Nakajima; Keiji Iwamoto; Iseki Takamoto; Youki Tsuji; Akira Ohno; Shuuichi Mori; Kumpei Tokuyama; Koji Murakami; Tomoichiro Asano; Shinichi Aizawa; Kazuyuki Tobe; Takashi Kadowaki; Yasuo Terauchi
Role of the liver in glucose homeostasis in PI 3-kinase p85alpha-deficient mice.
American journal of physiology. Endocrinology and metabolism 2009;296(4):E842-53.
2009: Taku Watanabe; Naoto Kubota; Miho Ohsugi; Tetsuya Kubota; Iseki Takamoto; Masato Iwabu; Motoharu Awazawa; Hisayuki Katsuyama; Chiaki Hasegawa; Kumpei Tokuyama; Masao Moroi; Kaoru Sugi; Toshimasa Yamauchi; Tetsuo Noda; Ryozo Nagai; Yasuo Terauchi; Kazuyuki Tobe; Kohjiro Ueki; Takashi Kadowaki
Rimonabant ameliorates insulin resistance via both adiponectin-dependent and adiponectin-independent pathways.
The Journal of biological chemistry 2009;284(3):1803-12.
2008: Naoto Kubota; Tetsuya Kubota; Shinsuke Itoh; Hiroki Kumagai; Hideki Kozono; Iseki Takamoto; Tomoka Mineyama; Hitomi Ogata; Kumpei Tokuyama; Miho Ohsugi; Takayoshi Sasako; Masao Moroi; Kaoru Sugi; Shigeru Kakuta; Yoichiro Iwakura; Tetsuo Noda; Shin Ohnishi; Ryozo Nagai; Kazuyuki Tobe; Yasuo Terauchi; Kohjiro Ueki; Takashi Kadowaki
Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding.
Cell metabolism 2008;8(1):49-64.
2008: Yumiko Oishi; Ichiro Manabe; Kazuyuki Tobe; Miho Ohsugi; Tetsuya Kubota; Katsuhito Fujiu; Koji Maemura; Naoto Kubota; Takashi Kadowaki; Ryozo Nagai
SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.
Nature medicine 2008;14(6):656-66.
2008: Satoshi Nishimura; Ichiro Manabe; Mika Nagasaki; Kinya Seo; Hiroshi Yamashita; Yumiko Hosoya; Miho Ohsugi; Kazuyuki Tobe; Takashi Kadowaki; Ryozo Nagai; Seiryo Sugiura
In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue.
The Journal of clinical investigation 2008;118(2):710-21.
2007: Naoto Kubota; Wataru Yano; Tetsuya Kubota; Toshimasa Yamauchi; Shinsuke Itoh; Hiroki Kumagai; Hideki Kozono; Iseki Takamoto; Shiki Okamoto; Tetsuya Shiuchi; Ryo Suzuki; Hidemi Satoh; Atsushi Tsuchida; Masao Moroi; Kaoru Sugi; Tetsuo Noda; Hiroyuki Ebinuma; Yoichi Ueta; Tatsuya Kondo; Eiichi Araki; Osamu Ezaki; Ryozo Nagai; Kazuyuki Tobe; Yasuo Terauchi; Kohjiro Ueki; Yasuhiko Minokoshi; Takashi Kadowaki
Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake.
Cell metabolism 2007;6(1):55-68.
2007: Satoshi Nishimura; Ichiro Manabe; Mika Nagasaki; Yumiko Hosoya; Hiroshi Yamashita; Hideo Fujita; Miho Ohsugi; Kazuyuki Tobe; Takashi Kadowaki; Ryozo Nagai; Seiryo Sugiura
Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels.
Diabetes 2007;56(6):1517-26.
2007: Toshimasa Yamauchi; Yasunori Nio; Toshiyuki Maki; Masaki Kobayashi; Takeshi Takazawa; Masato Iwabu; Miki Okada-Iwabu; Sachiko Kawamoto; Naoto Kubota; Tetsuya Kubota; Yusuke Ito; Junji Kamon; Atsushi Tsuchida; Katsuyoshi Kumagai; Hideki Kozono; Yusuke Hada; Hitomi Ogata; Kumpei Tokuyama; Masaki Tsunoda; Tomohiro Ide; Kouji Murakami; Motoharu Awazawa; Iseki Takamoto; philippe froguel; Kazuo Hara; Kazuyuki Tobe; Ryozo Nagai; Kohjiro Ueki; Takashi Kadowaki
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.
Nature medicine 2007;13(3):332-9.
2007: Naohiro Kawamura; Fumitaka Kugimiya; Yasushi Oshima; Shinsuke Ohba; Toshiyuki Ikeda; Taku Saito; Yusuke Shinoda; Yosuke Kawasaki; Naoshi Ogata; Kazuto Hoshi; Toru Akiyama; William S Chen; Nissim Hay; Kazuyuki Tobe; Takashi Kadowaki; Yoshiaki Azuma; Sakae Tanaka; Kozo Nakamura; Ung-il Chung; Hiroshi Kawaguchi
Akt1 in osteoblasts and osteoclasts controls bone remodeling.
PloS one 2007;2(10):e1058.
2007: Yasuo Terauchi; Iseki Takamoto; Naoto Kubota; Junji Matsui; Ryo Suzuki; Kajuro Komeda; Akemi Hara; Yukiyasu Toyoda; Ichitomo Miwa; Shinichi Aizawa; Shuichi Tsutsumi; Yoshiharu Tsubamoto; Shinji Hashimoto; Kazuhiro Eto; Akinobu Nakamura; Mitsuhiko Noda; Kazuyuki Tobe; Hiroyuki Aburatani; Ryozo Nagai; Takashi Kadowaki
Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.
The Journal of clinical investigation 2007;117(1):246-57.
2006: Taku Watanabe; Kazuyuki Tobe; Takashi Kadowaki; Nozomu Kamei
[Insulin resistance in central nerve system].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():158-62.
2006: Sumie Okahata; Kazuyuki Tobe; Yasuo Terauchi
[Postprandial hyperglycemia].
Nihon rinsho. Japanese journal of clinical medicine 2006;Suppl 3():17-25.
2006: Nozomu Kamei; Kazuyuki Tobe; Ryo Suzuki; Miho Ohsugi; Taku Watanabe; Naoto Kubota; Norie Ohtsuka-Kowatari; Katsuyoshi Kumagai; Kentaro Sakamoto; Masatoshi Kobayashi; Toshimasa Yamauchi; Kohjiro Ueki; Yumiko Oishi; Satoshi Nishimura; Ichiro Manabe; Haruo Hashimoto; Yasuyuki Ohnishi; Hitomi Ogata; Kumpei Tokuyama; Masaki Tsunoda; Tomohiro Ide; Koji Murakami; Ryozo Nagai; Takashi Kadowaki
Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance.
The Journal of biological chemistry 2006;281(36):26602-14.
2006: Takashi Kadowaki; Toshimasa Yamauchi; Naoto Kubota; Kazuo Hara; Kohjiro Ueki; Kazuyuki Tobe
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.
The Journal of clinical investigation 2006;116(7):1784-92.
2006: Kazuo Hara; Momoko Horikoshi; Hiroshi Kitazato; Chikako Ito; Mitsuhiko Noda; Jun Ohashi; philippe froguel; Katsushi Tokunaga; Kazuyuki Tobe; Ryozo Nagai; Takashi Kadowaki
Hepatocyte nuclear factor-4alpha P2 promoter haplotypes are associated with type 2 diabetes in the Japanese population.
Diabetes 2006;55(5):1260-4.
2006: Naoto Kubota; Yasuo Terauchi; Tetsuya Kubota; Hiroki Kumagai; Shinsuke Itoh; Hidemi Satoh; Wataru Yano; Hitomi Ogata; Kumpei Tokuyama; Iseki Takamoto; Tomoka Mineyama; Michiro Ishikawa; Masao Moroi; Kaoru Sugi; Toshimasa Yamauchi; Kohjiro Ueki; Kazuyuki Tobe; Tetsuo Noda; Ryozo Nagai; Takashi Kadowaki
Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways.
The Journal of biological chemistry 2006;281(13):8748-55.
2006: Kazuyuki Tobe; Toshimasa Yamauchi; Naoto Kubota; Kazuo Hara; Kohjiro Ueki; Takashi Kadowaki
[Pathogenesis of metabolic syndrome].
Seikagaku. The Journal of Japanese Biochemical Society 2006;78(3):208-20.
2005: Miho Ohsugi; Kazuyuki Tobe; Tetsuya Kubota; Naoto Kubota; Yasuo Terauchi; Takashi Kadowaki
[Gene targeting approaches for diabetes research].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 6():111-24.
2005: Ryo Suzuki; Kazuyuki Tobe; Masashi Aoyama; Kentaro Sakamoto; Miho Ohsugi; Nozomu Kamei; Shigeyuki Nemoto; Atsushi Inoue; Yusuke Ito; Shoko Uchida; Kazuo Hara; Toshimasa Yamauchi; Naoto Kubota; Yasuo Terauchi; Takashi Kadowaki
Expression of DGAT2 in white adipose tissue is regulated by central leptin action.
The Journal of biological chemistry 2005;280(5):3331-7.
2005: Kazuyuki Tobe; Shigeyuki Nemoto; Takashi Kadowaki
[Molecular mechanism of insulin resistance].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 2():114-30.
2005: Yumiko Oishi; Ichiro Manabe; Kazuyuki Tobe; Kensuke Tsushima; Takayuki Shindo; Katsuhito Fujiu; Go Nishimura; Koji Maemura; Toshimasa Yamauchi; Naoto Kubota; Ryo Suzuki; Toshio Kitamura; Shizuo Akira; Takashi Kadowaki; Ryozo Nagai
Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation.
Cell metabolism 2005;1(1):27-39.
2004: Junji Kamon; Toshimasa Yamauchi; Susumu Muto; Sato Takekawa; Yusuke Ito; Yusuke Hada; Wataru Ogawa; Akiko Itai; Masato Kasuga; Kazuyuki Tobe; Takashi Kadowaki
A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance.
Biochemical and biophysical research communications 2004;323(1):242-8.
2004: Naoto Kubota; Yasuo Terauchi; Kazuyuki Tobe; Wataru Yano; Ryo Suzuki; Kohjiro Ueki; Iseki Takamoto; Hidemi Satoh; Toshiyuki Maki; Tetsuya Kubota; Masao Moroi; Miki Okada-Iwabu; Osamu Ezaki; Ryozo Nagai; Yoichi Ueta; Takashi Kadowaki; Tetsuo Noda
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.
The Journal of clinical investigation 2004;114(7):917-27.
2004: Atsushi Tsuchida; Toshimasa Yamauchi; Yusuke Ito; Yusuke Hada; Toshiyuki Maki; Sato Takekawa; Junji Kamon; Masaki Kobayashi; Ryo Suzuki; Kazuo Hara; Naoto Kubota; Yasuo Terauchi; philippe froguel; Jun Nakae; Masato Kasuga; Domenico Accili; Kazuyuki Tobe; Kohjiro Ueki; Ryozo Nagai; Takashi Kadowaki
Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity.
The Journal of biological chemistry 2004;279(29):30817-22.
2004: Ryo Suzuki; Kazuyuki Tobe; Masashi Aoyama; Atsushi Inoue; Kentaro Sakamoto; Toshimasa Yamauchi; Junji Kamon; Naoto Kubota; Yasuo Terauchi; Hironobu Yoshimatsu; Munehide Matsuhisa; Shoichiro Nagasaka; Hitomi Ogata; Kumpei Tokuyama; Ryozo Nagai; Takashi Kadowaki
Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice.
The Journal of biological chemistry 2004;279(24):25039-49.
2003: Toshimasa Yamauchi; Kazuo Hara; Naoto Kubota; Yasuo Terauchi; Kazuyuki Tobe; philippe froguel; Ryozo Nagai; Takashi Kadowaki
Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine.
Current drug targets. Immune, endocrine and metabolic disorders 2003;3(4):243-54.
2003: Takashi Kadowaki; Kazuo Hara; Toshimasa Yamauchi; Yasuo Terauchi; Kazuyuki Tobe; Ryozo Nagai
Molecular mechanism of insulin resistance and obesity.
Experimental biology and medicine (Maywood, N.J.) 2003;228(10):1111-7.
2003: Ryo Suzuki; Kazuyuki Tobe; Yasuo Terauchi; Kajuro Komeda; Naoto Kubota; Kazuhiro Eto; Toshimasa Yamauchi; Kousuke Azuma; Hideaki Kaneto; Takashi Taguchi; Teiichiro Koga; Michael S German; Hirotaka Watada; Ryuzo Kawamori; Christopher V E Wright; Yoshitaka Kajimoto; Satoshi Kimura; Ryozo Nagai; Takashi Kadowaki
Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.
The Journal of biological chemistry 2003;278(44):43691-8.
2003: Kazuo Hara; Toshimasa Yamauchi; Naoto Kubota; Kazuyuki Tobe; Tsutomu Yamazaki; Ryozo Nagai; Takashi Kadowaki
[The role of PPARgamma in the onset of type 2 diabetes].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2003;122(4):317-24.
2003: Toshimasa Yamauchi; Junji Kamon; Yusuke Ito; Atsushi Tsuchida; Takehiko Yokomizo; Shunbun Kita; Takuya Sugiyama; Makoto Miyagishi; Kazuo Hara; Masaki Tsunoda; Koji Murakami; Toshiaki Ohteki; Shoko Uchida; Sato Takekawa; Hironori Waki; Nelson H Tsuno; Yoichi Shibata; Yasuo Terauchi; philippe froguel; Kazuyuki Tobe; Shigeo Koyasu; Kazunari Taira; Toshio Kitamura; Takao Shimizu; Ryozo Nagai; Takashi Kadowaki
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.
Nature 2003;423(6941):762-9.
2003: Yasuo Terauchi; Junji Matsui; Ryo Suzuki; Naoto Kubota; Kajuro Komeda; Shinichi Aizawa; Kazuhiro Eto; Satoshi Kimura; Ryozo Nagai; Kazuyuki Tobe; Gustav E Lienhard; Takashi Kadowaki
Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice.
The Journal of biological chemistry 2003;278(16):14284-90.
2003: Kazuyuki Tobe; Shohji Asai; Koozi Matuoka; Tadashi Yamamoto; Kazuhiro Chida; Yasushi Kaburagi; Yasuo Akanuma; Toshio Kuroki; Tadaomi Takenawa; Satoshi Kimura; Ryozo Nagai; Takashi Kadowaki
Cytoskeletal reorganization induced by insulin: involvement of Grb2/Ash, Ras and phosphatidylinositol 3-kinase signalling.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(1):29-40.
2002: Toru Akune; Naoshi Ogata; Kazuto Hoshi; Naoto Kubota; Yasuo Terauchi; Kazuyuki Tobe; Hideko Takagi; Yoshiaki Azuma; Takashi Kadowaki; Kozo Nakamura; Hiroshi Kawaguchi
Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts.
The Journal of cell biology 2002;159(1):147-56.
2002: Atsushi Inoue; Kazuyuki Tobe; Ryo Suzuki; Takashi Kadowaki
[Glucose metabolism in adipose tissue].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 10():673-80.
2002: Kazuo Hara; Mitsuhiko Noda; Hironori Waki; Kazuyuki Tobe; Toshimasa Yamauchi; Hiroko Kadowaki; Hiroaki Satou; Kazuhisa Tsukamoto; Shinya Nagamatsu; Kazuhiro Yamagata; Yuji Matsuzawa; Yasuo Akanuma; Satoshi Kimura; Takashi Kadowaki
Maturity-onset diabetes of the young resulting from a novel mutation in the HNF-4alpha gene.
Internal medicine (Tokyo, Japan) 2002;41(10):848-52.
2002: Yasushi Imai; Takayuki Shindo; Koji Maemura; Masataka Sata; Yuichiro Saito; Yukiko Kurihara; Masahiro Akishita; Jun-ichi Osuga; Shun Ishibashi; Kazuyuki Tobe; Hiroyuki Morita; Yoshio Oh-hashi; Toru Suzuki; Hiromitsu Maekawa; Kenji Kangawa; Naoto Minamino; Yoshio Yazaki; Ryozo Nagai; Hiroki Kurihara
Resistance to neointimal hyperplasia and fatty streak formation in mice with adrenomedullin overexpression.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(8):1310-5.
2002: Takayuki Shindo; Ichiro Manabe; Yasushi Fukushima; Kazuyuki Tobe; Kenichi Aizawa; Saku Miyamoto; Keiko Kawai-Kowase; Nobuo Moriyama; Yasushi Imai; Hayato Kawakami; Hiroaki Nishimatsu; Takashi Ishikawa; Toru Suzuki; Hiroyuki Morita; Koji Maemura; Masataka Sata; Yasunobu Hirata; Masayuki Komukai; Hiroyuki Kagechika; Takashi Kadowaki; Masahiko Kurabayashi; Ryozo Nagai
Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.
Nature medicine 2002;8(8):856-63.
2002: Kazuo Hara; Kazuyuki Tobe; Terumasa Okada; Hiroko Kadowaki; Yasuo Akanuma; Chikako Ito; Satoshi Kimura; Takashi Kadowaki
A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes.
Diabetologia 2002;45(5):740-3.
2002: Yasumichi Mori; Shuichi Otabe; Christian Dina; Kazuki Yasuda; Céline Populaire; Cécile Lecoeur; Vincent Vatin; Emmanuelle Durand; Kazuo Hara; Terumasa Okada; Kazuyuki Tobe; Philippe Boutin; Takashi Kadowaki; philippe froguel
Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p.
Diabetes 2002;51(4):1247-55.
2002: Kazuo Hara; Philippe Boutin; Yasumichi Mori; Kazuyuki Tobe; Christian Dina; Kazuki Yasuda; Toshimasa Yamauchi; Shuichi Otabe; Terumasa Okada; Kazuhiro Eto; Hiroko Kadowaki; Ryoko Hagura; Yasuo Akanuma; Yoshio Yazaki; Ryozo Nagai; Matsuo Taniyama; Koichi Matsubara; Madoka Yoda; Yasuko Nakano; Motowo Tomita; Satoshi Kimura; Chikako Ito; philippe froguel; Takashi Kadowaki
Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.
Diabetes 2002;51(2):536-40.
2002: Takashi Kadowaki; Kazuo Hara; Naoto Kubota; Kazuyuki Tobe; Yasuo Terauchi; Toshimasa Yamauchi; Kazuhiro Eto; Hiroko Kadowaki; Mitsuhiko Noda; Ryoko Hagura; Yasuo Akanuma
The role of PPARgamma in high-fat diet-induced obesity and insulin resistance.
Journal of diabetes and its complications 2002;16(1):41-5.
2002: Kazuhiro Eto; Tokuyuki Yamashita; Yoshiharu Tsubamoto; Yasuo Terauchi; Kenzo Hirose; Naoto Kubota; Shigeo Yamashita; Junko Taka; Shinobu Satoh; Hisahiko Sekihara; Kazuyuki Tobe; Masamitsu Iino; Mitsuhiko Noda; Satoshi Kimura; Takashi Kadowaki
Phosphatidylinositol 3-kinase suppresses glucose-stimulated insulin secretion by affecting post-cytosolic [Ca(2+)] elevation signals.
Diabetes 2002;51(1):87-97.
2001: Toshimasa Yamauchi; Junji Kamon; Hironori Waki; Koji Murakami; Kiyoto Motojima; Kajuro Komeda; Tomohiro Ide; Naoto Kubota; Yasuo Terauchi; Kazuyuki Tobe; Hiroshi Miki; Atsushi Tsuchida; Yasuo Akanuma; Ryozo Nagai; Satoshi Kimura; Takashi Kadowaki
The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance.
The Journal of biological chemistry 2001;276(44):41245-54.
2001: Kazuyuki Tobe; Ryo Suzuki; Masashi Aoyama; Toshimasa Yamauchi; Junji Kamon; Naoto Kubota; Yasuo Terauchi; Junji Matsui; Yasuo Akanuma; Satoshi Kimura; J Tanaka; Masato Abe; J Ohsumi; Ryozo Nagai; Takashi Kadowaki
Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver.
The Journal of biological chemistry 2001;276(42):38337-40.
2001: Toshimasa Yamauchi; Hironori Waki; Junji Kamon; Koji Murakami; Kiyoto Motojima; Kajuro Komeda; Hiroshi Miki; Naoto Kubota; Yasuo Terauchi; Atsushi Tsuchida; Nobuyo Tsuboyama-Kasaoka; N Yamauchi; Tomohiro Ide; W Hori; Shigeaki Kato; Masashi Fukayama; Yasuo Akanuma; Osamu Ezaki; Akiko Itai; Ryozo Nagai; Satoshi Kimura; Kazuyuki Tobe; Hiroyuki Kagechika; Koichi Shudo; Takashi Kadowaki
Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes.
The Journal of clinical investigation 2001;108(7):1001-13.
2001: Toshimasa Yamauchi; Junji Kamon; Hironori Waki; Yasuo Terauchi; Naoto Kubota; Kazuo Hara; Yasumichi Mori; Tomohiro Ide; Koji Murakami; Nobuyo Tsuboyama-Kasaoka; Osamu Ezaki; Yasuo Akanuma; Oksana Gavrilova; C Vinson; Marc L Reitman; Hiroyuki Kagechika; Koichi Shudo; M Yoda; Y Nakano; Kazuyuki Tobe; Ryozo Nagai; Satoshi Kimura; Motowo Tomita; philippe froguel; Takashi Kadowaki
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.
Nature medicine 2001;7(8):941-6.
2001: Y Tsuji; Yasushi Kaburagi; Yasuo Terauchi; Shinobu Satoh; Naoto Kubota; H Tamemoto; Fredric B Kraemer; Hisahiko Sekihara; Shin Aizawa; Yasuo Akanuma; Kazuyuki Tobe; Satoshi Kimura; Takashi Kadowaki
Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice.
Diabetes 2001;50(6):1455-63.
2001: H Miki; T Yamauchi; R Suzuki; Kajuro Komeda; Atsushi Tsuchida; Naoto Kubota; Yasuo Terauchi; Junji Kamon; Yasushi Kaburagi; Junji Matsui; Yasuo Akanuma; Ryozo Nagai; Satoshi Kimura; Kazuyuki Tobe; T Kadowaki
Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation.
Molecular and cellular biology 2001;21(7):2521-32.
2001: E Saitoh; S Okamoto; K T Takahashi; Kazuyuki Tobe; K Yamamoto; T Kimura; S Ishihara; S Maekawa; Y Tokura
Observation of orbital waves as elementary excitations in a solid.
Nature 2001;410(6825):180-3.
2001: Terumasa Okada; Kazuyuki Tobe; Kazuo Hara; Kazuki Yasuda; Y Kawaguchi; H Ikegami; Chikako Ito; Takashi Kadowaki
Variants of neurogenin 3 gene are not associated with Type II diabetes in Japanese subjects.
Diabetologia 2001;44(2):241-4.
2000: Kazuo Hara; Naoto Kubota; Kazuyuki Tobe; Yasuo Terauchi; H Miki; Kajuro Komeda; H Tamemoto; Toshimasa Yamauchi; Ryoko Hagura; Chikako Ito; Yasuo Akanuma; Takashi Kadowaki
The role of PPARgamma as a thrifty gene both in mice and humans.
The British journal of nutrition 2000;84 Suppl 2():S235-9.
2000: Naoto Kubota; Kazuyuki Tobe; Yasuo Terauchi; Kazuhiro Eto; Toshimasa Yamauchi; Ryo Suzuki; Yoshiharu Tsubamoto; Kajuro Komeda; R Nakano; H Miki; Shinobu Satoh; Hisahiko Sekihara; S Sciacchitano; MA Lesniak; Shin Aizawa; Ryozo Nagai; Satoshi Kimura; Yasuo Akanuma; Simeon I Taylor; Takashi Kadowaki
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.
Diabetes 2000;49(11):1880-9.
2000: Toshimasa Yamauchi; N Yamauchi; Keisuke Ueki; Takashi Sugiyama; Hironori Waki; Hiroshi Miki; Kazuyuki Tobe; S Matsuda; T Tsushima; Tadashi Yamamoto; Tomoyuki Fujita; Y Taketani; Masashi Fukayama; Satoshi Kimura; Yoshio Yazaki; Ryozo Nagai; Takashi Kadowaki
Constitutive tyrosine phosphorylation of ErbB-2 via Jak2 by autocrine secretion of prolactin in human breast cancer.
The Journal of biological chemistry 2000;275(43):33937-44.
2000: Keisuke Ueki; Toshimasa Yamauchi; H Tamemoto; Kazuyuki Tobe; Ritsuko Yamamoto-Honda; Yasushi Kaburagi; Yasuo Akanuma; Yoshio Yazaki; Shin Aizawa; Ryozo Nagai; Takashi Kadowaki
Restored insulin-sensitivity in IRS-1-deficient mice treated by adenovirus-mediated gene therapy.
The Journal of clinical investigation 2000;105(10):1437-45.
2000: Kazuo Hara; Terumasa Okada; Kazuyuki Tobe; Kazuki Yasuda; Yasumichi Mori; Hiroko Kadowaki; Ryoko Hagura; Yasuo Akanuma; Satoshi Kimura; Chikako Ito; Takashi Kadowaki
The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes.
Biochemical and biophysical research communications 2000;271(1):212-6.
2000: Naoshi Ogata; Daichi Chikazu; Naoto Kubota; Yasuo Terauchi; Kazuyuki Tobe; Yoshiaki Azuma; T Ohta; Takashi Kadowaki; Kozo Nakamura; Hiroshi Kawaguchi
Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover.
The Journal of clinical investigation 2000;105(7):935-43.
2000: Kazuo Hara; Kazuyuki Tobe; Y Uchigata; M Nakazono; Kazuki Yasuda; Y Terauchi; Y Iwamoto; Yasuo Akanuma; Satoshi Kimura; Takashi Kadowaki
Antibody-mediated insulin resistance treated by cessation of insulin administration.
Internal medicine (Tokyo, Japan) 2000;39(2):143-5.
2000: Hiroo Ueno; E Kondo; Ritsuko Yamamoto-Honda; Kazuyuki Tobe; Tetsuya Nakamoto; Kazuki Sasaki; Kinuko Mitani; A Furusaka; Toshihiro Tanaka; Y Tsujimoto; Takashi Kadowaki; Hisamura Hirai
Association of insulin receptor substrate proteins with Bcl-2 and their effects on its phosphorylation and antiapoptotic function.
Molecular biology of the cell 2000;11(2):735-46.
1999: Yoshinori Seko; N Takahashi; H Sabe; Kazuyuki Tobe; Takashi Kadowaki; Ryozo Nagai
Hypoxia induces activation and subcellular translocation of focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes.
Biochemical and biophysical research communications 1999;262(1):290-6.
1999: N Takahashi; Yoshinori Seko; Eisei Noiri; Kazuyuki Tobe; Takashi Kadowaki; H Sabe; Yoshio Yazaki
Vascular endothelial growth factor induces activation and subcellular translocation of focal adhesion kinase (p125FAK) in cultured rat cardiac myocytes.
Circulation research 1999;84(10):1194-202.
1999: Yoshinori Seko; N Takahashi; Kazuyuki Tobe; Takashi Kadowaki; Yoshio Yazaki
Pulsatile stretch activates mitogen-activated protein kinase (MAPK) family members and focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes.
Biochemical and biophysical research communications 1999;259(1):8-14.
1999: Yasushi Kaburagi; Toshimasa Yamauchi; Ritsuko Yamamoto-Honda; Keisuke Ueki; Kazuyuki Tobe; Yasuo Akanuma; Yoshio Yazaki; Takashi Kadowaki
The mechanism of insulin-induced signal transduction mediated by the insulin receptor substrate family.
Endocrine journal 1999;46 Suppl():S25-34.
1998: Koji Murakami; Kazuyuki Tobe; Tomohiro Ide; T Mochizuki; M Ohashi; Yasuo Akanuma; Yoshio Yazaki; Takashi Kadowaki
A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats.
Diabetes 1998;47(12):1841-7.
1998: Toshimasa Yamauchi; Yasushi Kaburagi; Keisuke Ueki; Y Tsuji; G R Stark; I M Kerr; T Tsushima; Yasuo Akanuma; Issei Komuro; Kazuyuki Tobe; Yoshio Yazaki; Takashi Kadowaki
Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase.
The Journal of biological chemistry 1998;273(25):15719-26.
1998: Yoshinori Seko; N Takahashi; Kazuyuki Tobe; K Ueki; Takashi Kadowaki; Yoshio Yazaki
Vascular endothelial growth factor (VEGF) activates Raf-1, mitogen-activated protein (MAP) kinases, and S6 kinase (p90rsk) in cultured rat cardiac myocytes.
Journal of cellular physiology 1998;175(3):239-46.
1998: Toshimasa Yamauchi; Keisuke Ueki; Kazuyuki Tobe; H Tamemoto; Nobuo Sekine; M Wada; M Honjo; Michio Takahashi; Tokiharu Takahashi; Hisamura Hirai; T Tsushima; Yasuo Akanuma; Tomoyuki Fujita; Issei Komuro; Yoshio Yazaki; Takashi Kadowaki
Growth hormone-induced tyrosine phosphorylation of EGF receptor as an essential element leading to MAP kinase activation and gene expression.
Endocrine journal 1998;45 Suppl():S27-31.
1998: Akira Okuno; H Tamemoto; Kazuyuki Tobe; Keisuke Ueki; Y Mori; K Iwamoto; K Umesono; Yasuo Akanuma; Toshihiko Fujiwara; H Horikoshi; Yoshio Yazaki; Takashi Kadowaki
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.
The Journal of clinical investigation 1998;101(6):1354-61.
1998: Keisuke Ueki; Ritsuko Yamamoto-Honda; Yasushi Kaburagi; Toshimasa Yamauchi; Kazuyuki Tobe; Boudewijn M T Burgering; Paul J Coffer; Issei Komuro; Yasuo Akanuma; Yoshio Yazaki; Takashi Kadowaki
Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis.
The Journal of biological chemistry 1998;273(9):5315-22.
1998: Yunzeng Zou; Issei Komuro; Tadashi Yamazaki; Sumiyo Kudoh; Ryuichi Aikawa; W Zhu; Ichiro Shiojima; Yukio Hiroi; Kazuyuki Tobe; Takashi Kadowaki; Yoshio Yazaki
Cell type-specific angiotensin II-evoked signal transduction pathways: critical roles of Gbetagamma subunit, Src family, and Ras in cardiac fibroblasts.
Circulation research 1998;82(3):337-45.
1998: H Tamemoto; T Izumi; Yasushi Kaburagi; Yasuo Terauchi; Kazuyuki Tobe; Takashi Kadowaki
[IRS-1 knockout mouse].
Nihon rinsho. Japanese journal of clinical medicine 1998;56 Suppl 3():738-45.
1997: Toshimasa Yamauchi; Keisuke Ueki; Kazuyuki Tobe; H Tamemoto; Nobuo Sekine; M Wada; M Honjo; Michio Takahashi; Tokiharu Takahashi; Hisamura Hirai; T Tushima; Yasuo Akanuma; Tomoyuki Fujita; Issei Komuro; Yoshio Yazaki; Takashi Kadowaki
Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone.
Nature 1997;390(6655):91-6.
1997: Yoshinori Seko; N Takahashi; Kazuyuki Tobe; Takashi Kadowaki; Yoshio Yazaki
Hypoxia and hypoxia/reoxygenation activate p65PAK, p38 mitogen-activated protein kinase (MAPK), and stress-activated protein kinase (SAPK) in cultured rat cardiac myocytes.
Biochemical and biophysical research communications 1997;239(3):840-4.
1997: Yasushi Kaburagi; Shinobu Satoh; H Tamemoto; Ritsuko Yamamoto-Honda; Kazuyuki Tobe; K Veki; Toshimasa Yamauchi; E Kono-Sugita; Hisahiko Sekihara; Shin Aizawa; S W Cushman; Yasuo Akanuma; Yoshio Yazaki; Takashi Kadowaki
Role of insulin receptor substrate-1 and pp60 in the regulation of insulin-induced glucose transport and GLUT4 translocation in primary adipocytes.
The Journal of biological chemistry 1997;272(41):25839-44.
1997: Kazuyuki Tobe; Takashi Kadowaki
[Defects in insulin's signalling process and diabetes mellitus].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():328-42.
1997: H Tamemoto; Kazuyuki Tobe; Toshimasa Yamauchi; Yasuo Terauchi; Yasushi Kaburagi; Takashi Kadowaki
Insulin resistance syndrome in mice deficient in insulin receptor substrate-1.
Annals of the New York Academy of Sciences 1997;827():85-93.
1997: Yasuo Terauchi; K Iwamoto; H Tamemoto; Kajuro Komeda; Chiaki Ishii; Y Kanazawa; N Asanuma; T Aizawa; Yasuo Akanuma; Kazuki Yasuda; Tatsuhiko Kodama; Kazuyuki Tobe; Yoshio Yazaki; Takashi Kadowaki
Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.
The Journal of clinical investigation 1997;99(5):861-6.
1997: Yasuhiro Takahashi; Kazuyuki Tobe; Hiroko Kadowaki; D Katsumata; Yasushi Fukushima; Yoshio Yazaki; Yasuo Akanuma; Takashi Kadowaki
Roles of insulin receptor substrate-1 and Shc on insulin-like growth factor I receptor signaling in early passages of cultured human fibroblasts.
Endocrinology 1997;138(2):741-50.
1996: Ritsuko Yamamoto-Honda; Zen-ichiro Honda; Keisuke Ueki; Kazuyuki Tobe; Yasushi Kaburagi; Yasuhiro Takahashi; H Tamemoto; T Suzuki; K Itoh; Yasuo Akanuma; Y Yazaki; Takashi Kadowaki
Mutant of insulin receptor substrate-1 incapable of activating phosphatidylinositol 3-kinase did not mediate insulin-stimulated maturation of Xenopus laevis oocytes.
The Journal of biological chemistry 1996;271(45):28677-81.
1996: Takashi Kadowaki; Kazuyuki Tobe; R Honda-Yamamoto; H Tamemoto; Yasushi Kaburagi; K Momomura; Keisuke Ueki; Yasuhiro Takahashi; Toshimasa Yamauchi; Yasuo Akanuma; Y Yazaki
Signal transduction mechanism of insulin and insulin-like growth factor-1.
Endocrine journal 1996;43 Suppl():S33-41.
1996: Yoshinori Seko; Kazuyuki Tobe; N Takahashi; Yasushi Kaburagi; Takashi Kadowaki; Y Yazaki
Hypoxia and hypoxia/reoxygenation activate Src family tyrosine kinases and p21ras in cultured rat cardiac myocytes.
Biochemical and biophysical research communications 1996;226(2):530-5.
1996: Takashi Kadowaki; H Tamemoto; Kazuyuki Tobe; Yasuo Terauchi; Keisuke Ueki; Yasushi Kaburagi; Toshimasa Yamauchi; S Satoh; Hisahiko Sekihara; Shin Aizawa; Y Yazaki
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 and identification of insulin receptor substrate-2.
Diabetic medicine : a journal of the British Diabetic Association 1996;13(9 Suppl 6):S103-8.
1996: Kazuyuki Tobe; H Sabe; T Yamamoto; Toshimasa Yamauchi; S Asai; Yasushi Kaburagi; H Tamemoto; Keisuke Ueki; H Kimura; Yasuo Akanuma; Y Yazaki; H Hanafusa; Takashi Kadowaki
Csk enhances insulin-stimulated dephosphorylation of focal adhesion proteins.
Molecular and cellular biology 1996;16(9):4765-72.
1996: Toshimasa Yamauchi; Kazuyuki Tobe; H Tamemoto; Keisuke Ueki; Yasushi Kaburagi; Ritsuko Yamamoto-Honda; Yasuhiro Takahashi; F Yoshizawa; Shin Aizawa; Yasuo Akanuma; N Sonenberg; Y Yazaki; Takashi Kadowaki
Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice.
Molecular and cellular biology 1996;16(6):3074-84.
1996: K Yoshikawa; Kazuyuki Tobe; Naoki Yoshioka; Hideo Yoshida
[MR imaging and dynamic MR imaging].
Nihon rinsho. Japanese journal of clinical medicine 1996;54(5):1255-62.
1996: Yoshinori Seko; Kazuyuki Tobe; Keisuke Ueki; Takashi Kadowaki; Y Yazaki
Hypoxia and hypoxia/reoxygenation activate Raf-1, mitogen-activated protein kinase kinase, mitogen-activated protein kinases, and S6 kinase in cultured rat cardiac myocytes.
Circulation research 1996;78(1):82-90.
1995: Tadashi Yamazaki; Issei Komuro; Sumiyo Kudoh; Yunzeng Zou; Ichiro Shiojima; T Mizuno; H Takano; Yukio Hiroi; Keisuke Ueki; Kazuyuki Tobe
Angiotensin II partly mediates mechanical stress-induced cardiac hypertrophy.
Circulation research 1995;77(2):258-65.
1995: Yasushi Kaburagi; Ritsuko Yamamoto-Honda; Kazuyuki Tobe; Keisuke Ueki; M Yachi; Yasuo Akanuma; R M Stephens; D Kaplan; Y Yazaki; Takashi Kadowaki
The role of the NPXY motif in the insulin receptor in tyrosine phosphorylation of insulin receptor substrate-1 and Shc.
Endocrinology 1995;136(8):3437-43.
1995: Tadashi Yamazaki; Issei Komuro; Sumiyo Kudoh; Yunzeng Zou; Ichiro Shiojima; T Mizuno; Hiroyuki Takano; Yukio Hiroi; Keisuke Ueki; Kazuyuki Tobe
Mechanical stress activates protein kinase cascade of phosphorylation in neonatal rat cardiac myocytes.
The Journal of clinical investigation 1995;96(1):438-46.
1995: Issei Komuro; Tadashi Yamazaki; Y Katoh; Kazuyuki Tobe; Takashi Kadowaki; Ryozo Nagai; Y Yazaki
Protein kinase cascade activated by mechanical stress in cardiocytes: possible involvement of angiotensin II.
European heart journal 1995;16 Suppl C():8-11.
1995: Kazuyuki Tobe; H Tamemoto; Toshimasa Yamauchi; Shin Aizawa; Y Yazaki; Takashi Kadowaki
Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1.
The Journal of biological chemistry 1995;270(11):5698-701.
1995: Ritsuko Yamamoto-Honda; Kazuyuki Tobe; Yasushi Kaburagi; Keisuke Ueki; S Asai; M Yachi; Mikako Shirouzu; J Yodoi; Yasuo Akanuma; Shigeyuki Yokoyama
Upstream mechanisms of glycogen synthase activation by insulin and insulin-like growth factor-I. Glycogen synthase activation is antagonized by wortmannin or LY294002 but not by rapamycin or by inhibiting p21ras.
The Journal of biological chemistry 1995;270(6):2729-34.
1995: N Morino; Toshihide Mimura; K Hamasaki; Kazuyuki Tobe; Keisuke Ueki; K Kikuchi; K Takehara; Takashi Kadowaki; Y Yazaki; Yoshihisa Nojima
Matrix/integrin interaction activates the mitogen-activated protein kinase, p44erk-1 and p42erk-2.
The Journal of biological chemistry 1995;270(1):269-73.
1994: H Tamemoto; Takashi Kadowaki; Kazuyuki Tobe; T Yagi; H Sakura; T Hayakawa; Yasuo Terauchi; Keisuke Ueki; Yasushi Kaburagi; S Satoh
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.
Nature 1994;372(6502):182-6.
1994: Kazuyuki Tobe; Keisuke Ueki; H Tamemoto; Yasushi Kaburagi; R Honda; Takashi Kadowaki
[The role of phosphorylation cascade in insulin action].
Nihon rinsho. Japanese journal of clinical medicine 1994;52(10):2673-85.
1994: Keisuke Ueki; S Matsuda; Kazuyuki Tobe; Y Gotoh; H Tamemoto; M Yachi; Yasuo Akanuma; Y Yazaki; E Nishida; Takashi Kadowaki
Feedback regulation of mitogen-activated protein kinase kinase kinase activity of c-Raf-1 by insulin and phorbol ester stimulation.
The Journal of biological chemistry 1994;269(22):15756-61.
1993: Yasushi Kaburagi; K Momomura; Ritsuko Yamamoto-Honda; Kazuyuki Tobe; Y Tamori; H Sakura; Yasuo Akanuma; Y Yazaki; Takashi Kadowaki
Site-directed mutagenesis of the juxtamembrane domain of the human insulin receptor.
The Journal of biological chemistry 1993;268(22):16610-22.
1993: Ritsuko Yamamoto-Honda; Takashi Kadowaki; K Momomura; Kazuyuki Tobe; Y Tamori; Yoshikazu Shibasaki; Y Mori; Yasushi Kaburagi; O Koshio; Yasuo Akanuma
Normal insulin receptor substrate-1 phosphorylation in autophosphorylation-defective truncated insulin receptor. Evidence that phosphorylation of substrates might be sufficient for certain biological effects evoked by insulin.
The Journal of biological chemistry 1993;268(22):16859-65.
1993: Tadashi Yamazaki; Kazuyuki Tobe; E Hoh; Koji Maemura; T Kaida; Issei Komuro; H Tamemoto; Takashi Kadowaki; Ryozo Nagai; Y Yazaki
Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes.
The Journal of biological chemistry 1993;268(16):12069-76.
1993: Kazuyuki Tobe; K Matuoka; H Tamemoto; Keisuke Ueki; Yasushi Kaburagi; S Asai; Tadashi Noguchi; M Matsuda; S Tanaka; S Hattori
Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2.
The Journal of biological chemistry 1993;268(15):11167-71.
1993: Y Yazaki; Issei Komuro; Tadashi Yamazaki; Kazuyuki Tobe; Koji Maemura; Takashi Kadowaki; Ryozo Nagai
Role of protein kinase system in the signal transduction of stretch-mediated protooncogene expression and hypertrophy of cardiac myocytes.
Molecular and cellular biochemistry 1993;119(1-2):11-6.
1992: Kazuyuki Tobe; Takashi Kadowaki; K Hara; Y Gotoh; H Kosako; S Matsuda; H Tamemoto; Keisuke Ueki; Yasuo Akanuma; E Nishida
Sequential activation of MAP kinase activator, MAP kinases, and S6 peptide kinase in intact rat liver following insulin injection.
The Journal of biological chemistry 1992;267(29):21089-97.
1992: H Tamemoto; Takashi Kadowaki; Kazuyuki Tobe; K Ueki; T Izumi; Y Chatani; Michiaki Kohno; M Kasuga; Y Yazaki; Yasuo Akanuma
Biphasic activation of two mitogen-activated protein kinases during the cell cycle in mammalian cells.
The Journal of biological chemistry 1992;267(28):20293-7.
1992: M Hashiramoto; Takashi Kadowaki; A E Clark; A Muraoka; K Momomura; H Sakura; Kazuyuki Tobe; Yasuo Akanuma; Y Yazaki; G D Holman
Site-directed mutagenesis of GLUT1 in helix 7 residue 282 results in perturbation of exofacial ligand binding.
The Journal of biological chemistry 1992;267(25):17502-7.
1992: A Ando; K Momomura; Kazuyuki Tobe; Ritsuko Yamamoto-Honda; H Sakura; Y Tamori; Yasushi Kaburagi; O Koshio; Yasuo Akanuma; Y Yazaki
Enhanced insulin-induced mitogenesis and mitogen-activated protein kinase activities in mutant insulin receptors with substitution of two COOH-terminal tyrosine autophosphorylation sites by phenylalanine.
The Journal of biological chemistry 1992;267(18):12788-96.
1992: Y Chatani; E Tanaka; Kazuyuki Tobe; A Hattori; M Sato; H Tamemoto; N Nishizawa; H Nomoto; T Takeya; Takashi Kadowaki
Mitogen-induced tyrosine-phosphorylated 41- and 43-kDa proteins are family members of extracellular signal-regulated kinases/microtubule-associated protein 2 kinases.
The Journal of biological chemistry 1992;267(14):9911-6.
1991: Kazuyuki Tobe; Takashi Kadowaki; H Tamemoto; Keisuke Ueki; K Hara; O Koshio; K Momomura; Y Gotoh; E Nishida; Yasuo Akanuma
Insulin and 12-O-tetradecanoylphorbol-13-acetate activation of two immunologically distinct myelin basic protein/microtubule-associated protein 2 (MBP/MAP2) kinases via de novo phosphorylation of threonine and tyrosine residues.
The Journal of biological chemistry 1991;266(36):24793-803.
1991: M Kawakami; E Nishida; Kazuyuki Tobe; M Hoshi; Takashi Kadowaki; M Kasuga; H Sakai
Activation of MAP kinase and enhanced phosphorylation of the 350-kDa protein by mitogenic stimuli in quiescent Balb/c 3T3 cells.
Experimental cell research 1991;193(1):120-6.
1990: Ritsuko Yamamoto-Honda; O Koshio; Kazuyuki Tobe; Yoshikazu Shibasaki; K Momomura; M Odawara; Takashi Kadowaki; F Takaku; Yasuo Akanuma; M Kasuga
Phosphorylation state and biological function of a mutant human insulin receptor Val996.
The Journal of biological chemistry 1990;265(25):14777-83.
1990: T Shiba; Kazuyuki Tobe; O Koshio; R Yamamoto; Yoshikazu Shibasaki; N Matsumoto; S Toyoshima; T Osawa; Yasuo Akanuma; F Takaku
Concanavalin A-induced receptor aggregation stimulates the tyrosine kinase activity of the insulin receptor in intact cells.
The Biochemical journal 1990;267(3):787-94.
1990: Kazuyuki Tobe; O Koshio; Y Tashiro-Hashimoto; F Takaku; Yasuo Akanuma; M Kasuga
Immunological detection of phosphotyrosine-containing proteins in rat livers after insulin injection.
Diabetes 1990;39(5):528-33.
1990: R Yamamoto; T Shiba; Kazuyuki Tobe; Yoshikazu Shibasaki; O Koshio; Takashi Izumi; M Odawara; Y Mikami; N Matsuura; Yasuo Akanuma
Defect in tyrosine kinase activity of the insulin receptor from a patient with insulin resistance and acanthosis nigricans.
The Journal of clinical endocrinology and metabolism 1990;70(4):869-78.
1990: M Kasuga; Takashi Izumi; Kazuyuki Tobe; T Shiba; K Momomura; Y Tashiro-Hashimoto; Takashi Kadowaki
Substrates for insulin-receptor kinase.
Diabetes care 1990;13(3):317-26.
1989: M Odawara; Takashi Kadowaki; R Yamamoto; Yoshikazu Shibasaki; Kazuyuki Tobe; D Accili; Charles L Bevins; Y Mikami; N Matsuura; Yasuo Akanuma
Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor.
Science (New York, N.Y.) 1989;245(4913):66-8.
1989: Y Tashiro-Hashimoto; Kazuyuki Tobe; O Koshio; Takashi Izumi; F Takaku; Yasuo Akanuma; M Kasuga
Tyrosine phosphorylation of pp185 by insulin receptor kinase in a cell-free system.
The Journal of biological chemistry 1989;264(12):6879-85.
1989: S Takayama-Hasumi; Kazuyuki Tobe; K Momomura; O Koshio; Y Tashiro-Hashimoto; Yasuo Akanuma; Yasunobu Hirata; F Takaku; M Kasuga
Autoantibodies to the insulin receptor (B-10) can stimulate tyrosine phosphorylation of the beta-subunit of the insulin receptor and a 185,000 molecular weight protein in rat hepatoma cells.
The Journal of clinical endocrinology and metabolism 1989;68(4):787-95.
1988: M Kasuga; Takashi Izumi; Kazuyuki Tobe; Takashi Kadowaki; K Momomura; S Takayama-Hasumi; O Koshio; Y Tashiro-Hashimoto; Yasuo Akanuma; F Takaku
Role of the insulin receptor kinase activity in insulin action.
Nihon Naibunpi Gakkai zasshi 1988;64(12):1243-9.
1988: E Nishida; Kazuyuki Tobe; Takashi Kadowaki; M Kasuga; C Sato; H Sakai
Stimulation of the phosphorylation of cytoskeletal 350-kDa and 300-kDa proteins by insulin-like growth factor-I, platelet-derived growth factor and phorbol ester in rat 3Y1 cells.
Cell structure and function 1988;13(5):417-23.
1988: K Momomura; Kazuyuki Tobe; Yousuke Seyama; F Takaku; M Kasuga
Insulin-induced tyrosine-phosphorylation in intact rat adipocytes.
Biochemical and biophysical research communications 1988;155(3):1181-6.