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John Todd

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Ricardo C Ferreira; Daniel F Freitag; Joanna M M Howson; Stephen Kaptoge; Anders Malarstig; Suna Onengut-Gumuscu; Marcin L Pekalski; Dan Rainbow; Stephen S Rich; Deborah J Smyth; Charlotte Boreham; Adam S Butterworth; Wei-Min Chen; Pamela Clarke; Richard M Coulson; Antony J Cutler; John Danesh; John A Todd
Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases.
Marcin Lukasz Pekalski; Deborah J Smyth; Helen E Stevens; John A Todd; Timothy I M Tree; Neil M Walker; Chris Wallace; Xaquin Castro Dopico; Gillian Coleman; Richard M R Coulson; Antony J Cutler; Calliope A Dendrou; Kate Downes; David B Dunger; L Esposito; Ricardo C Ferreira; Hui Guo; Catherine Guy; Sarah Nutland; Linda S Wicker
Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors.
Jason D Cooper; Jayne A Franklyn; Oliver J Brand; Oliver Burren; Gillian Coleman; Hui Guo; Matthew J Simmonds; Helen Stevens; John A Todd; Neil M Walker; Chris Wallace; Stephen C L Gough
Seven newly identified loci for autoimmune thyroid disease.

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All Publications

2013: Ricardo C Ferreira; Daniel F Freitag; Joanna M M Howson; Stephen Kaptoge; Anders Malarstig; Suna Onengut-Gumuscu; Marcin L Pekalski; Dan Rainbow; Stephen S Rich; Deborah J Smyth; Charlotte Boreham; Adam S Butterworth; Wei-Min Chen; Pamela Clarke; Richard M Coulson; Antony J Cutler; John Danesh; John A Todd
Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases.
PLoS genetics 2013;9(4):e1003444.
2013: Marcin Lukasz Pekalski; Deborah J Smyth; Helen E Stevens; John A Todd; Timothy I M Tree; Neil M Walker; Chris Wallace; Xaquin Castro Dopico; Gillian Coleman; Richard M R Coulson; Antony J Cutler; Calliope A Dendrou; Kate Downes; David B Dunger; L Esposito; Ricardo C Ferreira; Hui Guo; Catherine Guy; Sarah Nutland; Linda S Wicker
Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(6):2554-66.
2012: Jason D Cooper; Jayne A Franklyn; Oliver J Brand; Oliver Burren; Gillian Coleman; Hui Guo; Matthew J Simmonds; Helen Stevens; John A Todd; Neil M Walker; Chris Wallace; Stephen C L Gough
Seven newly identified loci for autoimmune thyroid disease.
Human molecular genetics 2012;21(23):5202-8.
2012: Xin Yang; David Clayton; John A Todd; Chris Wallace
Extra-binomial variation approach for analysis of pooled DNA sequencing data.
Bioinformatics (Oxford, England) 2012;28(22):2898-904.
2012: Simon M McHugh; Sam R Miller; Alison M Pickett; Jill C Richardson; Shilina Roman; John A Todd; Sally Wetten; Charles J Cox; Bill Davis; Fredrik Karpe; Annelize Koch; Edward T Bullmore
Effects of genetic variation in the P2RX7 gene on pharmacodynamics of a P2X(7) receptor antagonist: a prospective genotyping approach.
British journal of clinical pharmacology 2012;74(2):376-80.
2012: Joanna M M Howson; J Hutton; S Krause; Deborah J Smyth; H Stevens; John A Todd; Janet M Wenzlau; Anette-G Ziegler; Ezio Bonifacio; Peter Achenbach
Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases.
Diabetologia 2012;55(7):1978-84.
2012: chris wallace; Jennie H M Yang; François Cambien; David G Clayton; Jason D Cooper; Mhairi McNeill; David Niblett; Catherine M Rice; Maxime Rotival; Deborah J Smyth; Laurence Tiret; John A Todd; Stefan Blankenberg
Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes.
Human molecular genetics 2012;21(12):2815-24.
2012: J D Cooper; G S Eisenbarth; H A Erlich; J M M Howson; C Julier; G Morahan; J Nerup; C Nierras; Flemming Pociot; M Rewers; S S Rich; Jin-Xiong She; D Smyth; H Stevens; John A Todd; N M Walker; J H M Yang; B Akolkar; P Concannon
Confirmation of novel type 1 diabetes risk loci in families.
Diabetologia 2012;55(4):996-1000.
2011: Nada M Saleh; Deborah J Smyth; Helen E Stevens; Louise Bell; Joanna M M Howson; Srilakshmi M Raj; Neil M Walker; chris wallace; John A Todd
Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes.
Diabetes/metabolism research and reviews 2011;27(8):838-43.
2011: Joanna M M Howson; Silke Rosinger; Deborah J Smyth; Bernhard O Boehm; John A Todd
Genetic analysis of adult-onset autoimmune diabetes.
Diabetes 2011;60(10):2645-53.
2011: Vincent Plagnol; Matthew J Simmonds; Deborah J Smyth; Helen Stevens; Polly J Bingley; Stephen C Gough; Jason P Hafler; Joanna M M Howson; Laura Jackson; Neil Walker; chris wallace; John A Todd
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
PLoS genetics 2011;7(8):e1002216.
2011: Javid P Mohammed; Carolyn Moule; Laurence B Peterson; Dan Rainbow; William M Ridgway; Paul B Savage; John A Todd; Linda S Wicker; MARSHA WILLS-KARP; Jan Clark; Heather I Fraser; Michael E Fusakio; Jochen Mattner
Identification of Cd101 as a susceptibility gene for Novosphingobium aromaticivorans-induced liver autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(1):337-49.
2011: Dan Rainbow; William M Ridgway; Charles A Steward; John A Todd; Jeffrey A Bluestone; Oliver Burren; Mikkel Christensen; Jan Clark; Erik B Finger; Heather I Fraser; Michael E Fusakio; J P Houchins; Sarah Howlett; Frank Koentgen; Emma L Masteller; Jochen Mattner; Javid P Mohammed; Val Moody; Carolyn Moule; Dieter Naf; Laurence B Peterson; Linda S Wicker
Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(1):325-36.
2011: Jennie H M Yang; Neil M Walker; Kate Downes; Joanna M M Howson; Sarah Nutland; Helen E Stevens; John A Todd
Evidence of association with type 1 diabetes in the SLC11A1 gene region.
BMC medical genetics 2011;12():59.
2011: Oliver Burren; Ellen C Adlem; Premanand Achuthan; Mikkel Christensen; Richard M R Coulson; John A Todd
T1DBase: update 2011, organization and presentation of large-scale data sets for type 1 diabetes research.
Nucleic acids research 2011;39(Database issue):D997-1001.
2010: John A Todd
D'oh! genes and environment cause Crohn's disease.
Cell 2010;141(7):1114-6.
2010: Erik Fung; Laura Esposito; John A Todd; Linda S Wicker
Multiplexed immunophenotyping of human antigen-presenting cells in whole blood by polychromatic flow cytometry.
Nature protocols 2010;5(2):357-70.
2010: Kate Downes; Marcin Lukasz Pekalski; Karen L Angus; Matthew Hardy; Sarah Nutland; Deborah J Smyth; Neil M Walker; chris wallace; John A Todd
Reduced expression of IFIH1 is protective for type 1 diabetes.
PloS one 2010;5(9):.
2010: chris wallace; Deborah J Smyth; Meeta Maisuria-Armer; Neil M Walker; John A Todd; David G Clayton
The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes.
Nature genetics 2010;42(1):68-71.
2009: Jason D Cooper; Neil M Walker; Barry C Healy; Deborah J Smyth; K Downes; John A Todd
Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1.
Genes and immunity 2009;10 Suppl 1():S95-120.
2009: Jason D Cooper; Neil M Walker; Deborah J Smyth; K Downes; Barry C Healy; John A Todd
Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families.
Genes and immunity 2009;10 Suppl 1():S85-94.
2009: Joanna M M Howson; Neil M Walker; Deborah J Smyth; John A Todd
Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families.
Genes and immunity 2009;10 Suppl 1():S74-84.
2009: S S Rich; B Akolkar; Patrick Concannon; Henry A Erlich; Joan E Hilner; C Julier; Grant Morahan; Jørn Nerup; C Nierras; Flemming Pociot; John A Todd
Current status and the future for the genetics of type I diabetes.
Genes and immunity 2009;10 Suppl 1():S128-31.
2009: S S Rich; B Akolkar; Patrick Concannon; Henry A Erlich; Joan E Hilner; C Julier; Grant Morahan; Jørn Nerup; C Nierras; Flemming Pociot; John A Todd
Overview of the Type I Diabetes Genetics Consortium.
Genes and immunity 2009;10 Suppl 1():S1-4.
2009: S M Raj; Joanna M M Howson; Neil M Walker; Jason D Cooper; Deborah J Smyth; S F Field; Helen E Stevens; John A Todd
No association of multiple type 2 diabetes loci with type 1 diabetes.
Diabetologia 2009;52(10):2109-16.
2009: John A Todd
Stem cells and a cure for type 1 diabetes?
Proceedings of the National Academy of Sciences of the United States of America 2009;106(37):15523-4.
2009: Jeffrey C Barrett; David G Clayton; Patrick Concannon; Beena Akolkar; Jason D Cooper; Henry A Erlich; Cécile Julier; Grant Morahan; Jørn Nerup; Concepcion Nierras; Vincent Plagnol; Flemming Pociot; Helen Schuilenburg; Deborah J Smyth; Helen Stevens; John A Todd; Neil M Walker; Stephen S Rich
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
Nature genetics 2009;41(6):703-7.
2009: M L Marcovecchio; R Neil Dalton; C P Schwarze; A Toby Prevost; H A W Neil; Carlo L Acerini; T Barrett; Jason D Cooper; Julie A Edge; J Shield; Barry Widmer; John A Todd; David D Dunger
Ambulatory blood pressure measurements are related to albumin excretion and are predictive for risk of microalbuminuria in young people with type 1 diabetes.
Diabetologia 2009;52(6):1173-81.
2009: Sergey Nejentsev; Neil Walker; David Riches; Michael Egholm; John A Todd
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.
Science (New York, N.Y.) 2009;324(5925):387-9.
2009: Patrick Concannon; Wei-Min Chen; Cécile Julier; Grant Morahan; Beena Akolkar; Henry A Erlich; Joan E Hilner; Jørn Nerup; Concepcion Nierras; Flemming Pociot; John A Todd; Stephen S Rich
Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium.
Diabetes 2009;58(4):1018-22.
2009: Vincent Plagnol; Deborah J Smyth; John A Todd; David G Clayton
Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13.
Biostatistics (Oxford, England) 2009;10(2):327-34.
2009: E Y M G Fung; Deborah J Smyth; Joanna M M Howson; Jason D Cooper; Neil M Walker; Helen Stevens; Linda S Wicker; John A Todd
Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.
Genes and immunity 2009;10(2):188-91.
2009: S S Rich; B Akolkar; P Concannon; Henry A Erlich; Joan E Hilner; C Julier; Grant Morahan; Jørn Nerup; C Nierras; Flemming Pociot; John A Todd
Results of the MHC fine mapping workshop.
Diabetes, obesity & metabolism 2009;11 Suppl 1():108-9.
2009: Joanna M M Howson; Neil M Walker; David Clayton; John A Todd
Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A.
Diabetes, obesity & metabolism 2009;11 Suppl 1():31-45.
2009: Calliope A Dendrou; Erik Fung; L Esposito; John A Todd; Linda S Wicker; Vincent Plagnol
Fluorescence intensity normalisation: correcting for time effects in large-scale flow cytometric analysis.
Advances in bioinformatics 2009;():476106.
2009: Edward J Carr; Menna R Clatworthy; Christopher E Lowe; John A Todd; Andrew Wong; Timothy J Vyse; Lavanya Kamesh; Richard Watts; Paul A Lyons; Kenneth G C Smith
Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis.
BMC medical genetics 2009;10():22.
2009: Lisa M Maier; Christopher E Lowe; Jason Cooper; Kate Downes; David E Anderson; Christopher Severson; Pamela M Clark; Brian Healy; Neil Walker; Cristin Aubin; Jorge R Oksenberg; Stephen L Hauser; Alistair Compston; Stephen Sawcer; Philip De Jager; Linda S Wicker; John A Todd; David A Hafler
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.
PLoS genetics 2009;5(1):e1000322.
2009: J P Hafler; Lisa M Maier; Jason D Cooper; Vincent Plagnol; A Hinks; M J Simmonds; Helen E Stevens; Neil M Walker; Barry Healy; Joanna M M Howson; M Maisuria; S Duley; G Coleman; S C L Gough; J Worthington; V K Kuchroo; Linda S Wicker; John A Todd
CD226 Gly307Ser association with multiple autoimmune diseases.
Genes and immunity 2009;10(1):5-10.
2008: Deborah J Smyth; Vincent Plagnol; Neil M Walker; Jason D Cooper; Kate Downes; Jennie H M Yang; Joanna M M Howson; Helen Stevens; Ross McManus; Cisca Wijmenga; Graham A Heap; Patrick C Dubois; David G Clayton; Karen A Hunt; David A van Heel; John A Todd
Shared and distinct genetic variants in type 1 diabetes and celiac disease.
The New England journal of medicine 2008;359(26):2767-77.
2008: Jason D Cooper; Deborah J Smyth; Adam M Smiles; Vincent Plagnol; Neil M Walker; James E Allen; Kate Downes; Jeffrey C Barrett; Barry C Healy; Josyf C Mychaleckyj; James H Warram; John A Todd
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
Nature genetics 2008;40(12):1399-401.
2008: Lisa M Maier; Sarah Howlett; Kara M Rainbow; Jan Clark; Joanna M M Howson; John A Todd; Linda S Wicker
NKG2D-RAE-1 receptor-ligand variation does not account for the NK cell defect in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):7073-80.
2008: David D Dunger; John A Todd
Prevention of type 1 diabetes: what next?
Lancet 2008;372(9651):1710-1.
2008: Patrick Concannon; Suna Onengut-Gumuscu; John A Todd; Deborah J Smyth; Flemming Pociot; Regine Bergholdt; Beena Akolkar; Henry A Erlich; Joan E Hilner; Cécile Julier; Grant Morahan; Jørn Nerup; Concepcion R Nierras; Wei-Min Chen; Stephen S Rich
A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3.
Diabetes 2008;57(10):2858-61.
2008: Dan B Rainbow; Laura Esposito; Sarah Howlett; Kara M Hunter; John A Todd; Laurence B Peterson; Linda S Wicker
Commonality in the genetic control of Type 1 diabetes in humans and NOD mice: variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species.
Biochemical Society transactions 2008;36(Pt 3):312-5.
2008: Sarah F Field; Sergey Nejentsev; Neil M Walker; Joanna M M Howson; Lisa M Taylor; Jennifer D Jolley; Matthew P A Hardy; John A Todd
Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes.
Diabetes 2008;57(6):1753-6.
2008: Deborah J Smyth; Jason D Cooper; Joanna M M Howson; Neil M Walker; Vincent Plagnol; Helen Stevens; David G Clayton; John A Todd
PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes.
Diabetes 2008;57(6):1730-7.
2008: Adrian Vella; N Bouatia-Naji; Barbara Heude; Jason D Cooper; Christopher E Lowe; Clive J Petry; Susan M Ring; David D Dunger; John A Todd; Ken K Ong
Association analysis of the IGF1 gene with childhood growth, IGF-1 concentrations and type 1 diabetes.
Diabetologia 2008;51(5):811-5.
2008: Sergey Nejentsev; Thorsten Thye; Jeffrey S Szeszko; Helen Stevens; Yanina Balabanova; Amanua M Chinbuah; Martin Hibberd; Esther van de Vosse; Alisjahbana Bachti; Reinout van Crevel; Tom H M Ottenhoff; Eileen Png; Francis Drobniewski; John A Todd; Mark Seielstad; Rolf D Horstmann
Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations.
Nature genetics 2008;40(3):261-2; author reply 262-3.
2008: William M Ridgway; Laurence B Peterson; John A Todd; Dan Rainbow; Barry Healy; Oliver S Burren; Linda S Wicker
Gene-gene interactions in the NOD mouse model of type 1 diabetes.
Advances in immunology 2008;100():151-75.
2008: Vincent Plagnol; Elif Uz; chris wallace; Helen Stevens; David Clayton; Tayfun Ozcelik; John A Todd
Extreme clonality in lymphoblastoid cell lines with implications for allele specific expression analyses.
PloS one 2008;3(8):e2966.
2008: Roger HORTON; Richard Gibson; Penny Coggill; Marcos M Miretti; Richard J N Allcock; Jeff Almeida; Simon Forbes; James G R Gilbert; Karen Halls; Jennifer L Harrow; Elizabeth Hart; Kevin L Howe; David K Jackson; Sophie Palmer; Anne N Roberts; Sarah Sims; Charles Stewart; James A Traherne; Steve Trevanion; Laurens G Wilming; Jane Rogers; Pieter J de Jong; John Elliott; Stephen Sawcer; John A Todd; John Trowsdale; Stephan Beck
Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project.
Immunogenetics 2008;60(1):1-18.
2007: Kara Hunter; Dan Rainbow; Vincent Plagnol; John A Todd; Laurence B Peterson; Linda S Wicker
Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(12):8341-9.
2007: Sergey Nejentsev; Joanna M M Howson; Neil M Walker; Jeffrey S Szeszko; Sarah F Field; Helen E Stevens; Pamela Reynolds; Matthew Hardy; Erna King; Jennifer Masters; John S Hulme; Lisa M Maier; Deborah Smyth; Rebecca Bailey; Jason D Cooper; Gloria Ribas; R Duncan Campbell; David G Clayton; John A Todd
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A.
Nature 2007;450(7171):887-92.
2007: Rebecca Bailey; Jason D Cooper; Lauren Zeitels; Deborah J Smyth; Jennie H M Yang; Neil M Walker; Elina Hyppönen; David D Dunger; Elizabeth Ramos Lopez; Klaus Badenhoop; Sergey Nejentsev; John A Todd
Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes.
Diabetes 2007;56(10):2616-21.
2007: Matthew J Simmonds; Joanna M M Howson; Joanne M Heward; Jackie Carr-Smith; Jayne A Franklyn; John A Todd; S C L Gough
A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect.
Human molecular genetics 2007;16(18):2149-53.
2007: Christopher E Lowe; Jason D Cooper; Todd Brusko; Neil M Walker; Deborah J Smyth; Rebecca Bailey; Kirsi Bourget; Vincent Plagnol; Sarah Field; Mark Atkinson; David G Clayton; Linda S Wicker; John A Todd
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.
Nature genetics 2007;39(9):1074-82.
2007: Vincent Plagnol; Jason D Cooper; John A Todd; David G Clayton
A method to address differential bias in genotyping in large-scale association studies.
PLoS genetics 2007;3(5):e74.
2007: Oliver J Brand; Christopher E Lowe; Joanne M Heward; Jayne A Franklyn; Jason D Cooper; John A Todd; S C L Gough
Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs.
Clinical endocrinology 2007;66(4):508-12.
2007: Joanna M M Howson; David D Dunger; Sarah Nutland; Helen Stevens; Linda S Wicker; John A Todd
A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene.
Diabetologia 2007;50(4):741-6.
2007: Jeffrey S Szeszko; Barry Healy; Helen Stevens; Yanina Balabanova; Francis Drobniewski; John A Todd; Sergey Nejentsev
Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis.
Human genetics 2007;121(2):155-60.
2007: Jun Yamanouchi; Dan Rainbow; Pau Serra; Sarah Howlett; Kara Hunter; Valerie E S Garner; Andrea Gonzalez-Munoz; Jan Clark; Riitta Veijola; Rose Cubbon; Show-Ling Chen; Raymond Rosa; Anne Marie Cumiskey; David V Serreze; Simon Gregory; Jane Rogers; Paul A Lyons; Barry Healy; Luc J Smink; John A Todd; Laurence B Peterson; Linda S Wicker; Pere Santamaria
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
Nature genetics 2007;39(3):329-37.
2007: Felicity Payne; Jason D Cooper; Neil M Walker; Alex C Lam; Luc J Smink; Sarah Nutland; Helen E Stevens; Jayne Hutchings; John A Todd
Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes.
Journal of leukocyte biology 2007;81(3):581-3.
2007: Jason D Cooper; Deborah J Smyth; Rebecca Bailey; Felicity Payne; Kate Downes; Lisa M Taylor; Jennifer Masters; Lauren R Zeitels; Adrian Vella; Neil M Walker; John A Todd
The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes.
BMC medical genetics 2007;8():71.
2007: david burke; Catherine L Worth; Eva-Maria Priego; Tammy Cheng; Luc J Smink; John A Todd; Tom L Blundell
Genome bioinformatic analysis of nonsynonymous SNPs.
BMC bioinformatics 2007;8():301.
2007: Sergey Nejentsev; Luc J Smink; Deborah Smyth; Rebecca Bailey; Christopher E Lowe; Felicity Payne; Jennifer Masters; Lisa M Taylor; Alex Lam; Oliver Burren; Helen Stevens; Sarah Nutland; Neil M Walker; Anne Smith; Rebecca C J Twells; Bryan J Barratt; Charmain Wright; Lisa French; Yuan Chen; Panos Deloukas; Jane Rogers; Carl Bruder; John A Todd
Sequencing and association analysis of the type 1 diabetes-linked region on chromosome 10p12-q11.
BMC genetics 2007;8():24.
2007: Erin M Hulbert; Luc J Smink; Ellen C Adlem; James E Allen; David B Burdick; Oliver Burren; Victor M Cassen; Christopher C Cavnor; Geoffrey E Dolman; Daisy Flamez; Karen F Friery; Barry C Healy; Sarah A Killcoyne; Burak Kutlu; Helen Schuilenburg; Neil M Walker; Josyf C Mychaleckyj; Decio L Eizirik; Linda S Wicker; John A Todd; Nathan Goodman
T1DBase: integration and presentation of complex data for type 1 diabetes research.
Nucleic acids research 2007;35(Database issue):D742-6.
2007: S F Field; Joanna M M Howson; Deborah J Smyth; Neil M Walker; David D Dunger; John A Todd
Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects.
Diabetologia 2007;50(1):212-3.
2006: Stephen S Rich; Patrick Concannon; Henry A Erlich; Cécile Julier; Grant Morahan; Jorn Nerup; Flemming Pociot; John A Todd
The Type 1 Diabetes Genetics Consortium.
Annals of the New York Academy of Sciences 2006;1079():1-8.
2006: Paul I W de Bakker; Gil McVean; Pardis C Sabeti; Marcos M Miretti; Todd Green; Jonathan Marchini; Xiayi Ke; Alienke J Monsuur; Pamela Whittaker; Marcos Delgado; Jonathan Morrison; Angela Richardson; Emily C Walsh; Xiaojiang Gao; Luana Galver; John Hart; David A Hafler; Margaret Pericak-Vance; John A Todd; Mark J Daly; John Trowsdale; Cisca Wijmenga; Timothy J Vyse; Stephan Beck; Sarah Shaw Murray; Mary Carrington; Simon Gregory; Panos Deloukas; John D Rioux
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC.
Nature genetics 2006;38(10):1166-72.
2006: Rebecca Pask; Jason D Cooper; Neil M Walker; Sarah Nutland; Jayne Hutchings; David D Dunger; Sergey Nejentsev; John A Todd
No evidence for a major effect of two common polymorphisms of the catalase gene in type 1 diabetes susceptibility.
Diabetes/metabolism research and reviews 2006;22(5):356-60.
2006: Lisa M Maier; Joanna M M Howson; Neil Walker; Gavin P Spickett; Richard W Jones; Susan M Ring; Wendy L McArdle; Christopher E Lowe; Rebecca Bailey; Felicity Payne; John A Todd; David P Strachan
Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes.
The Journal of allergy and clinical immunology 2006;117(6):1306-13.
2006: Deborah J Smyth; Jason D Cooper; Rebecca Bailey; Sarah Field; Oliver Burren; Luc J Smink; Cristian Guja; Constantin Ionescu-Tirgoviste; Barry Widmer; David D Dunger; David A Savage; Neil M Walker; David G Clayton; John A Todd
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.
Nature genetics 2006;38(6):617-9.
2006: Deborah J Smyth; Jason D Cooper; Christopher E Lowe; Sarah Nutland; Neil M Walker; David G Clayton; John A Todd
No evidence for association of OAS1 with type 1 diabetes in unaffected siblings or type 1 diabetic cases.
Diabetes 2006;55(5):1525-8.
2006: Mathew Barber; John A Todd; Heather J Cordell
A multimarker regression-based test of linkage for affected sib-pairs at two linked loci.
Genetic epidemiology 2006;30(3):191-208.
2006: Jeffrey S Szeszko; Joanna M M Howson; Jason D Cooper; Neil M Walker; Rebecca C J Twells; Helen E Stevens; Sarah Nutland; John A Todd
Analysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing.
Diabetes 2006;55(2):559-62.
2006: Hidenori Taniguchi; Christopher E Lowe; Jason D Cooper; Deborah J Smyth; Rebecca Bailey; Sarah Nutland; Barry C Healy; Alex C Lam; Oliver Burren; Neil M Walker; Luc J Smink; Linda S Wicker; John A Todd
Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes.
BMC genetics 2006;7():22.
2006: Deborah J Smyth; Joanna M M Howson; Felicity Payne; Lisa M Maier; Rebecca Bailey; Kieran Holland; Christopher E Lowe; Jason D Cooper; John S Hulme; Adrian Vella; Ingrid Dahlman; Alex C Lam; Sarah Nutland; Neil M Walker; Rebecca C J Twells; John A Todd
Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.
BMC medical genetics 2006;7():20.
2006: Gerard A J Morris; Christopher E Lowe; Jason D Cooper; Felicity Payne; Adrian Vella; Lisa M Taylor; John S Hulme; Neil M Walker; Barry C Healy; Alex C Lam; Paul A Lyons; John A Todd
Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes.
BMC genetics 2006;7():12.
2006: James A Traherne; Roger HORTON; Anne N Roberts; Marcos M Miretti; Matthew E Hurles; Charles Stewart; Jennifer L Ashurst; Alexey Atrazhev; Penny Coggill; Sophie Palmer; Jeff Almeida; Sarah Sims; Laurens G Wilming; Jane Rogers; Pieter J de Jong; Mary Carrington; John Elliott; Stephen Sawcer; John A Todd; John Trowsdale; Stephan Beck
Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history.
PLoS genetics 2006;2(1):e9.
2005: David G Clayton; Neil M Walker; Deborah J Smyth; Rebecca Pask; Jason D Cooper; Lisa M Maier; Luc J Smink; Alex C Lam; Nigel R Ovington; Helen E Stevens; Sarah Nutland; Joanna M M Howson; Malek Faham; Martin Moorhead; Hywel B Jones; Matthew Falkowski; Paul Hardenbol; Thomas D Willis; John A Todd
Population structure, differential bias and genomic control in a large-scale, case-control association study.
Nature genetics 2005;37(11):1243-6.
2005: Patrick Concannon; Henry A Erlich; Cécile Julier; Grant Morahan; Jørn Nerup; Flemming Pociot; John A Todd; Stephen S Rich
Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families.
Diabetes 2005;54(10):2995-3001.
2005: Lisa M Maier; J D Cooper; N Walker; Deborah J Smyth; John A Todd
Comment to: Biason-Lauber A, Boehm B, Lang-Muritano M et al. (2005) association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 48:900-905.
Diabetologia 2005;48(10):2180-2; author reply 2185-6.
2005: Jennifer L Cannons; Giselle Chamberlain; Joanna M M Howson; Luc J Smink; John A Todd; Laurence B Peterson; Linda S Wicker; Tania H Watts
Genetic and functional association of the immune signaling molecule 4-1BB (CD137/TNFRSF9) with type 1 diabetes.
Journal of autoimmunity 2005;25(1):13-20.
2005: Joanna M M Howson; Bryan J Barratt; John A Todd; Heather J Cordell
Comparison of population- and family-based methods for genetic association analysis in the presence of interacting loci.
Genetic epidemiology 2005;29(1):51-67.
2005: Felicity Payne; Deborah J Smyth; Rebecca Pask; Jason D Cooper; Jennifer Masters; William Y S Wang; Lisa M Taylor; Georgina Bowden; Jeffrey S Szeszko; Luc J Smink; Alex C Lam; Oliver Burren; Neil M Walker; Sarah Nutland; Helen E Rance; DAG UNDLIEN; Kjersti S Rønningen; Cristian Guja; Constantin Ionescu-Tîrgovişte; John A Todd; Rebecca C J Twells
No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes.
Biochemical and biophysical research communications 2005;331(2):435-41.
2005: Adrian Vella; Jason D Cooper; Christopher E Lowe; Neil Walker; Sarah Nutland; Barry Widmer; Richard Jones; Susan M Ring; Wendy L McArdle; Marcus E Pembrey; David P Strachan; David D Dunger; Rebecca C J Twells; David G Clayton; John A Todd
Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms.
American journal of human genetics 2005;76(5):773-9.
2005: Lisa M Maier; Juliet Chapman; Joanna M M Howson; David G Clayton; Rebecca Pask; David P Strachan; Wendy L McArdle; Rebecca C J Twells; John A Todd
No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.
American journal of human genetics 2005;76(3):517-21.
2005: William Y S Wang; Bryan J Barratt; David G Clayton; John A Todd
Genome-wide association studies: theoretical and practical concerns.
Nature reviews. Genetics 2005;6(2):109-18.
2005: Deborah J Smyth; Joanna M M Howson; Christopher E Lowe; Neil M Walker; Alex C Lam; Sarah Nutland; Jayne Hutchings; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; Cristian Guja; Constantin Ionescu-Tîrgoviste; DAG UNDLIEN; Kjersti S Rønningen; David Savage; David D Dunger; Rebecca C J Twells; Wendy L McArdle; David P Strachan; John A Todd
Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes.
Nature genetics 2005;37(2):110-1; author reply 112-3.
2005: Linda S Wicker; Jan Clark; Heather I Fraser; Valerie E S Garner; Andrea Gonzalez-Munoz; Barry Healy; Sarah Howlett; Kara Hunter; Dan Rainbow; Raymond L Rosa; Luc J Smink; John A Todd; Laurence B Peterson
Type 1 diabetes genes and pathways shared by humans and NOD mice.
Journal of autoimmunity 2005;25 Suppl():29-33.
2005: Linda S Wicker; Carolyn Moule; Heather Fraser; Carlos Penha-Goncalves; Dan Rainbow; Valerie E S Garner; Giselle Chamberlain; Kara Hunter; Sarah Howlett; Jan Clark; Andrea Gonzalez-Munoz; Anne Marie Cumiskey; Paul Tiffen; Joanna M M Howson; Barry Healy; Luc J Smink; Amanda Kingsnorth; Paul A Lyons; Simon Gregory; Jane Rogers; John A Todd; Laurence B Peterson
Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse.
Novartis Foundation symposium 2005;267():57-65; discussion 65-75.
2005: Clive J Petry; Ken K Ong; Bryan J Barratt; Dianne L Wingate; Heather J Cordell; Susan M Ring; Marcus E Pembrey; Wolf Reik; John A Todd; David D Dunger
Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans.
BMC genetics 2005;6():22.
2005: Lisa M Maier; Deborah J Smyth; Adrian Vella; Felicity Payne; Jason D Cooper; Rebecca Pask; Christopher Lowe; John S Hulme; Luc J Smink; Heather Fraser; Carolyn Moule; Kara M Hunter; Giselle Chamberlain; Neil Walker; Sarah Nutland; DAG UNDLIEN; Kjersti S Rønningen; Cristian Guja; Constantin Ionescu-Tîrgoviste; David A Savage; David P Strachan; Laurence B Peterson; John A Todd; Linda S Wicker; Rebecca C J Twells
Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes.
BMC genetics 2005;6():9.
2005: Luc J Smink; Erin M Helton; Barry C Healy; Christopher C Cavnor; Alex C Lam; Daisy Flamez; Oliver Burren; Yang Wang; Geoffrey E Dolman; David B Burdick; Vincent H Everett; Gustavo Glusman; Davide Laneri; Lee Rowen; Helen Schuilenburg; Neil M Walker; Josyf C Mychaleckyj; Linda S Wicker; Decio L Eizirik; John A Todd; Nathan Goodman
T1DBase, a community web-based resource for type 1 diabetes research.
Nucleic acids research 2005;33(Database issue):D544-9.
2005: Matthew J Simmonds; Joanna M M Howson; Joanne M Heward; Heather J Cordell; Helen Foxall; Jackie Carr-Smith; Sarah M Gibson; Neil Walker; Yaron Tomer; Jayne A Franklyn; John A Todd; S C L Gough
Regression mapping of association between the human leukocyte antigen region and Graves disease.
American journal of human genetics 2005;76(1):157-63.
2004: Costantino Motzo; Daniela Contu; Heather J Cordell; Rosanna Lampis; Mauro Congia; Maria Giovanna Marrosu; John A Todd; Marcella Devoto; Francesco Cucca
Heterogeneity in the magnitude of the insulin gene effect on HLA risk in type 1 diabetes.
Diabetes 2004;53(12):3286-91.
2004: Deborah Smyth; Jason D Cooper; Joanne E Collins; Joanne M Heward; Jayne A Franklyn; Joanna M M Howson; Adrian Vella; Sarah Nutland; Helen E Rance; Lisa Maier; Bryan J Barratt; Cristian Guja; Constantin Ionescu-Tîrgoviste; David A Savage; David D Dunger; Barry Widmer; David P Strachan; Susan M Ring; Neil Walker; David G Clayton; Rebecca C J Twells; S C L Gough; John A Todd
Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.
Diabetes 2004;53(11):3020-3.
2004: Sergey Nejentsev; Jason D Cooper; Lisa M Taylor; Joanna M M Howson; Helen E Rance; Sarah Nutland; Neil M Walker; Cristian Guja; Constantin Ionescu-Tirgovişte; David A Savage; DAG UNDLIEN; Kjersti S Rønningen; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; Kathleen M Gillespie; Susan M Ring; David P Strachan; Barry Widmer; David D Dunger; John A Todd
Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes.
Diabetes 2004;53(10):2709-12.
2004: John S Hulme; Bryan J Barratt; Rebecca C J Twells; Jason D Cooper; Christopher E Lowe; Joanna M M Howson; Alex C Lam; Luc J Smink; David A Savage; DAG UNDLIEN; Cristian Guja; Constantin Ionescu-Tîirgoviste; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; John A Todd
Association analysis of the lymphocyte-specific protein tyrosine kinase (LCK) gene in type 1 diabetes.
Diabetes 2004;53(9):2479-82.
2004: Syuichi Koarada; Yuehong Wu; Noreen Fertig; David A Sass; Michael A Nalesnik; John A Todd; Paul A Lyons; Judith Fenyk-Melody; Dan Rainbow; Linda S Wicker; Laurence B Peterson; William M Ridgway
Genetic control of autoimmunity: protection from diabetes, but spontaneous autoimmune biliary disease in a nonobese diabetic congenic strain.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(4):2315-23.
2004: A Paul Lambert; Kathleen M Gillespie; Glenys Thomson; Heather J Cordell; John A Todd; Edwin A M Gale; Polly J Bingley
Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United Kingdom.
The Journal of clinical endocrinology and metabolism 2004;89(8):4037-43.
2004: Sergey Nejentsev; Lisa M Taylor; Hywel Snook; Helen E Rance; Sarah Nutland; Neil M Walker; Alex C Lam; Cristian Guja; Constantin Ionescu-Tirgoviste; DAG UNDLIEN; Kjersti S Rønningen; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; Melanie J Newport; David G Clayton; John A Todd
Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene.
Human molecular genetics 2004;13(15):1633-9.
2004: Rebecca Pask; Helen E Rance; Bryan J Barratt; Sarah Nutland; Deborah J Smyth; Meera Sebastian; Rebecca C J Twells; Anne Smith; Alex C Lam; Luc J Smink; Neil M Walker; John A Todd
Investigating the utility of combining phi29 whole genome amplification and highly multiplexed single nucleotide polymorphism BeadArray genotyping.
BMC biotechnology 2004;4():15.
2004: Patrizia Zavattari; Elisabetta Deidda; Maristella Pitzalis; Barbara Zoa; Loredana Moi; Rosanna Lampis; Daniela Contu; Costantino Motzo; Paola Frongia; Efisio Angius; Mario Maioli; John A Todd; Francesco Cucca
No association between variation of the FOXP3 gene and common type 1 diabetes in the Sardinian population.
Diabetes 2004;53(7):1911-4.
2004: Bryan J Barratt; Felicity Payne; Christopher E Lowe; Robert Hermann; Barry C Healy; Denise Harold; Patrick Concannon; Neda Gharani; Mark I McCarthy; Mark Olavesen; Rose McCormack; Cristian Guja; Constantin Ionescu-Tîrgovişte; DAG UNDLIEN; Kjersti S Rønningen; Kathleen M Gillespie; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; Simon T Bennett; David G Clayton; Heather J Cordell; John A Todd
Remapping the insulin gene/IDDM2 locus in type 1 diabetes.
Diabetes 2004;53(7):1884-9.
2004: Linda S Wicker; Giselle Chamberlain; Kara Hunter; Dan Rainbow; Sarah Howlett; Paul Tiffen; Jan Clark; Andrea Gonzalez-Munoz; Anne Marie Cumiskey; Raymond L Rosa; Joanna M M Howson; Luc J Smink; Amanda Kingsnorth; Paul A Lyons; Simon Gregory; Jane Rogers; John A Todd; Laurence B Peterson
Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):164-73.
2004: Charles Stewart; Roger HORTON; Richard J N Allcock; Jennifer L Ashurst; Alexey Atrazhev; Penny Coggill; Carl Bruder; Simon Forbes; Karen Halls; Joanna M M Howson; Sean Humphray; Sarah Hunt; Andrew Mungall; Kazutoyo Osoegawa; Sophie Palmer; Anne N Roberts; Jane Rogers; Sarah Sims; Yu Wang; Laurens G Wilming; John Elliott; Pieter J de Jong; Stephen Sawcer; John A Todd; John Trowsdale; Stephan Beck
Complete MHC haplotype sequencing for common disease gene mapping.
Genome research 2004;14(6):1176-87.
2004: Christopher E Lowe; Jason D Cooper; Juliet M Chapman; Bryan J Barratt; Rebecca C J Twells; E Allison Green; David A Savage; Cristian Guja; C Ionescu-Tîrgovişte; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; John A Todd; David G Clayton
Cost-effective analysis of candidate genes using htSNPs: a staged approach.
Genes and immunity 2004;5(4):301-5.
2004: JE Collins; Joanne M Heward; Ratnasingam Nithiyananthan; S Nejentsev; John A Todd; Jayne A Franklyn; S C L Gough
Lack of association of the vitamin D receptor gene with Graves' disease in UK Caucasians.
Clinical endocrinology 2004;60(5):618-24.
2004: Cristian Guja; L Guja; Sarah Nutland; Helen E Rance; M Sebastien; John A Todd; Constantin Ionescu-Tirgoviste
Type 1 diabetes genetic susceptibility encoded by HLA DQB1 genes in Romania.
Journal of cellular and molecular medicine 2004;8(2):249-56.
2004: Karen F Tait; T Marshall; J Berman; Jackie Carr-Smith; B Rowe; John A Todd; Stephen C Bain; Anthony H Barnett; S C L Gough
Clustering of autoimmune disease in parents of siblings from the Type 1 diabetes Warren repository.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(4):358-62.
2004: Agnes A Awomoyi; Sergey Nejentsev; Anna Richardson; Jeremy Hull; Oliver Koch; M Podinovskaia; John A Todd; Keith P W J McAdam; Jenefer M Blackwell; Dominic Kwiatkowski; Melanie J Newport
No association between interferon-gamma receptor-1 gene polymorphism and pulmonary tuberculosis in a Gambian population sample.
Thorax 2004;59(4):291-4.
2004: Adrian Vella; Joanna M M Howson; Bryan J Barratt; Rebecca C J Twells; Helen E Rance; Sarah Nutland; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; DAG UNDLIEN; Kjersti S Rønningen; Cristian Guja; Constantin Ionescu-Tîrgovişte; David A Savage; John A Todd
Lack of association of the Ala(45)Thr polymorphism and other common variants of the NeuroD gene with type 1 diabetes.
Diabetes 2004;53(4):1158-61.
2004: Ken K Ong; Clive J Petry; Bryan J Barratt; Susan M Ring; Heather J Cordell; Dianne L Wingate; Marcus E Pembrey; John A Todd; David D Dunger
Maternal-fetal interactions and birth order influence insulin variable number of tandem repeats allele class associations with head size at birth and childhood weight gain.
Diabetes 2004;53(4):1128-33.
2004: Karen F Tait; JE Collins; Joanne M Heward; Iain A Eaves; Hywel Snook; Jayne A Franklyn; Anthony H Barnett; John A Todd; Mel Maranian; Alastair Compston; Stephen Sawcer; S C L Gough
Evidence for a Type 1 diabetes-specific mechanism for the insulin gene-associated IDDM2 locus rather than a general influence on autoimmunity.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(3):267-70.
2004: Christina Eftychi; Joanna M M Howson; Bryan J Barratt; Adrian Vella; Felicity Payne; Deborah J Smyth; Rebecca C J Twells; Neil M Walker; Helen E Rance; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; DAG UNDLIEN; Kjersti S Rønningen; Cristian Guja; Constantin Ionescu-Tîirgovişte; David A Savage; John A Todd
Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes.
Diabetes 2004;53(3):870-3.
2004: Felicity Payne; Deborah J Smyth; Rebecca Pask; Bryan J Barratt; Jason D Cooper; Rebecca C J Twells; Neil M Walker; Alex C Lam; Luc J Smink; Sarah Nutland; Helen E Rance; John A Todd
Haplotype tag single nucleotide polymorphism analysis of the human orthologues of the rat type 1 diabetes genes Ian4 (Lyp/Iddm1) and Cblb.
Diabetes 2004;53(2):505-9.
2004: Oliver Burren; Barry C Healy; Alex C Lam; Helen Schuilenburg; Geoffrey E Dolman; Vincent H Everett; Davide Laneri; Sarah Nutland; Helen E Rance; Felicity Payne; Deborah Smyth; Chris Lowe; Bryan J Barratt; Rebecca C J Twells; Dan Rainbow; Linda S Wicker; John A Todd; Neil M Walker; Luc J Smink
Development of an integrated genome informatics, data management and workflow infrastructure: a toolbox for the study of complex disease genetics.
Human genomics 2004;1(2):98-109.
2004: Cristian Guja; Loreta Guja; Sarah Nutland; Helen E Rance; John A Todd; C Ionescu-Tîrgovişte
Strong association of insulin gene INS-VNTR polymorphisms with type 1 diabetes in the Romanian population.
Romanian journal of internal medicine = Revue roumaine de médecine interne 2004;42(2):313-23.
2003: William Y S Wang; John A Todd
The usefulness of different density SNP maps for disease association studies of common variants.
Human molecular genetics 2003;12(23):3145-9.
2003: Sergey Nejentsev; Cristian Guja; Rose McCormack; Jason Cooper; Joanna M M Howson; Sarah Nutland; Helen E Rance; Neil Walker; DAG UNDLIEN; Kjersti S Ronningen; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; Constantin Ionescu-Tirgoviste; Edwin A M Gale; Polly J Bingley; Kathleen M Gillespie; David A Savage; Dennis J Carson; Chris C Patterson; A Peter Maxwell; John A Todd
Association of intercellular adhesion molecule-1 gene with type 1 diabetes.
Lancet 2003;362(9397):1723-4.
2003: Lisa M Maier; Rebecca C J Twells; Joanna M M Howson; Alex C Lam; David G Clayton; Deborah J Smyth; David Savage; D Carson; Chris C Patterson; Luc J Smink; Neil M Walker; Oliver Burren; Sarah Nutland; Helen E Rance; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; Cristian Guja; Constantin Ionescu-Tirgoviste; DAG UNDLIEN; Kjersti S Rønningen; Francesco Cucca; John A Todd
Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene.
Genes and immunity 2003;4(7):469-75.
2003: Hiroyuki Shiono; Ioannis Roxanis; Wei Zhang; Gary P Sims; Anthony Meager; LW Jacobson; Jian-Li Liu; Ian Matthews; Y-L Wong; M Bonifati; Kingsley Micklem; David I Stott; John A Todd; David Beeson; Angela Vincent; Nick Willcox
Scenarios for autoimmunization of T and B cells in myasthenia gravis.
Annals of the New York Academy of Sciences 2003;998():237-56.
2003: Rebecca C J Twells; Charles A Mein; Felicity Payne; Riitta Veijola; Matthew Gilbey; Matthew Bright; Andrew Timms; Yusuke Nakagawa; Hywel Snook; Sarah Nutland; Helen E Rance; Philippa Carr; Frank Dudbridge; Heather J Cordell; Jason Cooper; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; Michael Phillips; Michael Metzker; J Fred Hess; John A Todd
Linkage and association mapping of the LRP5 locus on chromosome 11q13 in type 1 diabetes.
Human genetics 2003;113(2):99-105.
2003: Carlos Penha-Gonçalves; Carolyn Moule; Luc J Smink; Joanna M M Howson; Simon Gregory; Jane Rogers; Paul A Lyons; Joseph J Suttie; christopher Lord; Laurence B Peterson; John A Todd; Linda S Wicker
Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice.
Diabetes 2003;52(6):1551-6.
2003: Rebecca C J Twells; Charles A Mein; Michael S Phillips; J Fred Hess; Riitta Veijola; Matthew Gilbey; Matthew Bright; Michael Metzker; Benedicte Lie; Amanda Kingsnorth; Edward Gregory; Yusuke Nakagawa; Hywel Snook; William Y S Wang; Jennifer Masters; Gillian Johnson; Iain A Eaves; Joanna M M Howson; David Clayton; Heather J Cordell; Sarah Nutland; Helen E Rance; Philippa Carr; John A Todd
Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene.
Genome research 2003;13(5):845-55.
2003: Juliet M Chapman; Jason D Cooper; John A Todd; David G Clayton
Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power.
Human heredity 2003;56(1-3):18-31.
2003: William Y S Wang; Heather J Cordell; John A Todd
Association mapping of complex diseases in linked regions: estimation of genetic effects and feasibility of testing rare variants.
Genetic epidemiology 2003;24(1):36-43.
2003: Frances A Brook; Edward P Evans; christopher Lord; Paul A Lyons; Dan Rainbow; Sarah K Howlett; Linda S Wicker; John A Todd; Richard L Gardner
The derivation of highly germline-competent embryonic stem cells containing NOD-derived genome.
Diabetes 2003;52(1):205-8.
2002: Daniela Contu; laura morelli; Patrizia Zavattari; Rosanna Lampis; Efisio Angius; Paola Frongia; Daniela Murru; Mario Maioli; Paolo Francalacci; John A Todd; Francesco Cucca
Sex-related bias and exclusion mapping of the nonrecombinant portion of chromosome Y in human type 1 diabetes in the isolated founder population of Sardinia.
Diabetes 2002;51(12):3573-6.
2002: Gillian C L Johnson; Bobby P C Koeleman; John A Todd
Limitations of stratifying sib-pair data in common disease linkage studies: an example using chromosome 10p14-10q11 in type 1 diabetes.
American journal of medical genetics 2002;113(2):158-66.
2002: Bryan J Barratt; Felicity Payne; Helen E Rance; Sarah Nutland; John A Todd; David G Clayton
Identification of the sources of error in allele frequency estimations from pooled DNA indicates an optimal experimental design.
Annals of human genetics 2002;66(Pt 5-6):393-405.
2002: Gillian C L Johnson; Felicity Payne; Sarah Nutland; Helen Stevens; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; John A Todd
A comprehensive, statistically powered analysis of GAD2 in type 1 diabetes.
Diabetes 2002;51(9):2866-70.
2002: Richard J N Allcock; Alexey Atrazhev; Stephan Beck; Pieter J de Jong; John Elliott; Simon Forbes; Karen Halls; Roger HORTON; Kazutoyo Osoegawa; Jane Rogers; Stephen Sawcer; John A Todd; John Trowsdale; Y Wang; S Williams
The MHC haplotype project: a resource for HLA-linked association studies.
Tissue antigens 2002;59(6):520-1.
2002: Ingrid Dahlman; Iain A Eaves; Roman Kosoy; V Anne Morrison; Joanne M Heward; S C L Gough; Amit Allahabadia; Jayne A Franklyn; Jaakko Tuomilehto; Eva Tuomilehto-Wolf; Francesco Cucca; Cristian Guja; Constantin Ionescu-Tirgoviste; Helen Stevens; Philippa Carr; Sarah Nutland; Patricia McKinney; Julian P H Shield; William Wang; Heather J Cordell; Neil Walker; John A Todd; Patrick Concannon
Parameters for reliable results in genetic association studies in common disease.
Nature genetics 2002;30(2):149-50.
2002: Cristian Guja; S Marshall; K Welsh; M Merriman; A Smith; John A Todd; Constantin Ionescu-Tîrgoviste
The study of CTLA-4 and vitamin D receptor polymorphisms in the Romanian type 1 diabetes population.
Journal of cellular and molecular medicine 2002;6(1):75-81.
2001: Paul A Lyons; N Armitage; christopher Lord; Michael S Phillips; John A Todd; Laurence B Peterson; Linda S Wicker
Mapping by genetic interaction: high-resolution congenic mapping of the type 1 diabetes loci Idd10 and Idd18 in the NOD mouse.
Diabetes 2001;50(11):2633-7.
2001: Constantin Ionescu-Tîrgoviste; Cristian Guja; MH Herr; E Cucca; K Welsh; Mike Bunce; S Marshall; John A Todd
Low frequency of HLA DRB1*03 - DQB1*02 and DQB1*0302 haplotypes in Romania is consistent with the country's low incidence of Type I diabetes.
Diabetologia 2001;44 Suppl 3():B60-6.
2001: Gillian C L Johnson; L Esposito; Bryan J Barratt; Annabel N Smith; Joanne M Heward; G Di Genova; H Ueda; Heather J Cordell; Iain A Eaves; Frank Dudbridge; Rebecca C J Twells; Felicity Payne; W Hughes; Sarah Nutland; Helen Stevens; Philippa Carr; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; S C L Gough; David G Clayton; John A Todd
Haplotype tagging for the identification of common disease genes.
Nature genetics 2001;29(2):233-7.
2001: Francesco Cucca; Rosanna Lampis; Mauro Congia; Efisio Angius; Sarah Nutland; SC Bain; AH Barnett; John A Todd
A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins.
Human molecular genetics 2001;10(19):2025-37.
2001: John A Todd; Linda S Wicker
Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models.
Immunity 2001;15(3):387-95.
2001: Francesco Cucca; Frank Dudbridge; M Loddo; AP Mulargia; Rosanna Lampis; Efisio Angius; Stefano De Virgiliis; Bobby P C Koeleman; SC Bain; AH Barnett; F Gilchrist; Heather J Cordell; K Welsh; John A Todd
The HLA-DPB1--associated component of the IDDM1 and its relationship to the major loci HLA-DQB1, -DQA1, and -DRB1.
Diabetes 2001;50(5):1200-5.
2001: Heather J Cordell; John A Todd; NJ Hill; christopher Lord; Paul A Lyons; Laurence B Peterson; L S Wicker; David G Clayton
Statistical modeling of interlocus interactions in a complex disease: rejection of the multiplicative model of epistasis in type 1 diabetes.
Genetics 2001;158(1):357-67.
2001: Patrizia Zavattari; Rosanna Lampis; Costantino Motzo; M Loddo; AP Mulargia; Michael B Whalen; Mario Maioli; Efisio Angius; John A Todd; Francesco Cucca
Conditional linkage disequilibrium analysis of a complex disease superlocus, IDDM1 in the HLA region, reveals the presence of independent modifying gene effects influencing the type 1 diabetes risk encoded by the major HLA-DQB1, -DRB1 disease loci.
Human molecular genetics 2001;10(8):881-9.
2001: Rebecca C J Twells; Michael Metzker; SD Brown; R Cox; C Garey; H Hammond; Patricia J Hey; E Levy; Yusuke Nakagawa; M S Philips; John A Todd; J Fred Hess
The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13.
Genomics 2001;72(3):231-42.
2001: christopher Lord; Sarah Howlett; Paul A Lyons; Laurence B Peterson; Linda S Wicker; John A Todd
The murine type 1 diabetes loci, Idd1, Idd3, Idd5, Idd9, and Idd17/10/18, do not control thymic CD4-CD8-/TCRalphabeta+ deficiency in the nonobese diabetic mouse.
Mammalian genome : official journal of the International Mammalian Genome Society 2001;12(2):175-6.
2000: Patrizia Zavattari; Rosanna Lampis; AP Mulargia; M Loddo; Efisio Angius; John A Todd; Francesco Cucca
Confirmation of the DRB1-DQB1 loci as the major component of IDDM1 in the isolated founder population of Sardinia.
Human molecular genetics 2000;9(20):2967-72.
2000: Rosanna Lampis; laura morelli; Mauro Congia; Maria Doloretta Macis; AP Mulargia; M Loddo; Stefano De Virgiliis; Maria Giovanna Marrosu; John A Todd; Francesco Cucca
The inter-regional distribution of HLA class II haplotypes indicates the suitability of the Sardinian population for case-control association studies in complex diseases.
Human molecular genetics 2000;9(20):2959-65.
2000: Patrizia Zavattari; Elisabetta Deidda; Michael B Whalen; Rosanna Lampis; AP Mulargia; M Loddo; Iain A Eaves; G Mastio; John A Todd; Francesco Cucca
Major factors influencing linkage disequilibrium by analysis of different chromosome regions in distinct populations: demography, chromosome recombination frequency and selection.
Human molecular genetics 2000;9(20):2947-57.
2000: Kathleen M Gillespie; S J Valovin; J Saunby; Kara M Hunter; David A Savage; DEREK MIDDLETON; John A Todd; Polly J Bingley; Edwin A M Gale
HLA class II typing of whole genome amplified mouth swab DNA.
Tissue antigens 2000;56(6):530-8.
2000: NJ Hill; Paul A Lyons; N Armitage; John A Todd; Linda S Wicker; Laurence B Peterson
NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.
Diabetes 2000;49(10):1744-7.
2000: David Figueroa; J Fred Hess; Betty Ky; SD Brown; V Sandig; A Hermanowski-Vosatka; Rebecca C J Twells; John A Todd; Christopher P Austin
Expression of the type I diabetes-associated gene LRP5 in macrophages, vitamin A system cells, and the Islets of Langerhans suggests multiple potential roles in diabetes.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2000;48(10):1357-68.
2000: T Siegmund; N Armitage; Linda S Wicker; Laurence B Peterson; John A Todd; Paul A Lyons
Analysis of the mouse CD30 gene: a candidate for the NOD mouse type 1 diabetes locus Idd9.2.
Diabetes 2000;49(9):1612-6.
2000: Paul A Lyons; W W Hancock; Paul Denny; christopher Lord; NJ Hill; N Armitage; T Siegmund; John A Todd; Michael S Phillips; J Fred Hess; S L Chen; P A Fischer; Laurence B Peterson; Linda S Wicker
The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137.
Immunity 2000;13(1):107-15.
2000: Iain A Eaves; Tony R Merriman; R A Barber; Sarah Nutland; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; Francesco Cucca; John A Todd
The genetically isolated populations of Finland and sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes.
Nature genetics 2000;25(3):320-3.
2000: Gillian C L Johnson; John A Todd
Strategies in complex disease mapping.
Current opinion in genetics & development 2000;10(3):330-4.
2000: Frank Dudbridge; Bobby P C Koeleman; John A Todd; David G Clayton
Unbiased application of the transmission/disequilibrium test to multilocus haplotypes.
American journal of human genetics 2000;66(6):2009-12.
2000: MH Herr; Frank Dudbridge; Patrizia Zavattari; Francesco Cucca; Cristian Guja; R March; R Duncan Campbell; AH Barnett; SC Bain; John A Todd; Bobby P C Koeleman
Evaluation of fine mapping strategies for a multifactorial disease locus: systematic linkage and association analysis of IDDM1 in the HLA region on chromosome 6p21.
Human molecular genetics 2000;9(9):1291-301.
2000: Bobby P C Koeleman; MH Herr; Patrizia Zavattari; Frank Dudbridge; R March; D Campbell; AH Barnett; SC Bain; AP Mulargia; M Loddo; William Amos; Francesco Cucca; John A Todd
Conditional ETDT analysis of the human leukocyte antigen region in type 1 diabetes.
Annals of human genetics 2000;64(Pt 3):215-21.
2000: Bobby P C Koeleman; Frank Dudbridge; Heather J Cordell; John A Todd
Adaptation of the extended transmission/disequilibrium test to distinguish disease associations of multiple loci: the Conditional Extended Transmission/Disequilibrium Test.
Annals of human genetics 2000;64(Pt 3):207-13.
2000: PL Podolin; MB Wilusz; Rose M Cubbon; U Pajvani; christopher Lord; John A Todd; Laurence B Peterson; Linda S Wicker; Paul A Lyons
Differential glycosylation of interleukin 2, the molecular basis for the NOD Idd3 type 1 diabetes gene?
Cytokine 2000;12(5):477-82.
2000: Paul A Lyons; N Armitage; F Argentina; Paul Denny; NJ Hill; christopher Lord; MB Wilusz; Laurence B Peterson; Linda S Wicker; John A Todd
Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping.
Genome research 2000;10(4):446-53.
2000: Charles A Mein; Bryan J Barratt; M G Dunn; T Siegmund; Annabel N Smith; L Esposito; Sarah Nutland; Helen E Stevens; A J Wilson; Michael S Phillips; N Jarvis; S Law; M de Arruda; John A Todd
Evaluation of single nucleotide polymorphism typing with invader on PCR amplicons and its automation.
Genome research 2000;10(3):330-43.
2000: Patrizia Zavattari; L Esposito; Sarah Nutland; John A Todd; Francesco Cucca
Transmission-ratio distortion at Xp11.4-p21.1 in type 1 diabetes.
American journal of human genetics 2000;66(1):330-2.
1999: John A Todd
Interpretation of results from genetic studies of multifactorial diseases.
Lancet 1999;354 Suppl 1():SI15-6.
1999: John A Todd
From genome to aetiology in a multifactorial disease, type 1 diabetes.
BioEssays : news and reviews in molecular, cellular and developmental biology 1999;21(2):164-74.
1998: L Esposito; N J Hill; L E Pritchard; Francesco Cucca; CE Muxworthy; Marilyn E Merriman; A Wilson; Cécile Julier; M Delepine; Jaakko Tuomilehto; Eva Tuomilehto-Wolf; C Ionesco-Tirgoviste; L Nistico'; Raffaella Buzzetti; Paolo Pozzilli; M Ferrari; Emanuele Bosi; Flemming Pociot; Jørn Nerup; SC Bain; John A Todd
Genetic analysis of chromosome 2 in type 1 diabetes: analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster. IMDIAB Group.
Diabetes 1998;47(11):1797-9.
1998: Francesco Cucca; L Esposito; JV Goy; Marilyn E Merriman; AJ Wilson; P W Reed; SC Bain; John A Todd
Investigation of linkage of chromosome 8 to type 1 diabetes: multipoint analysis and exclusion mapping of human chromosome 8 in 593 affected sib-pair families from the U.K. and U.S.
Diabetes 1998;47(9):1525-7.
1998: Patricia J Hey; Rebecca C J Twells; Michael S Phillips; SD Brown; Y Kawaguchi; R Cox; V Dugan; H Hammond; Michael Metzker; John A Todd; J Fred Hess
Cloning of a novel member of the low-density lipoprotein receptor family.
Gene 1998;216(1):103-11.
1998: P Vafiadis; Simon T Bennett; John A Todd; Rosemary Grabs; Constantin Polychronakos
Divergence between genetic determinants of IGF2 transcription levels in leukocytes and of IDDM2-encoded susceptibility to type 1 diabetes.
The Journal of clinical endocrinology and metabolism 1998;83(8):2933-9.
1998: Y Nakagawa; Y Kawaguchi; Rebecca C J Twells; CE Muxworthy; Kara M Hunter; A Wilson; Marilyn E Merriman; Roger D Cox; Tony R Merriman; Francesco Cucca; PA McKinney; Julian P H Shield; Jaakko Tuomilehto; Eva Tuomilehto-Wolf; C Ionesco-Tirgoviste; Lorenza Nisticò; R Buzzetti; Paolo Pozzilli; Geir Joner; Erik Thorsby; DAG UNDLIEN; Flemming Pociot; Jørn Nerup; K S Rönningen; SC Bain; John A Todd
Fine mapping of the diabetes-susceptibility locus, IDDM4, on chromosome 11q13.
American journal of human genetics 1998;63(2):547-56.
1998: SD Brown; Rebecca C J Twells; Patricia J Hey; Roger D Cox; ER Levy; A R Soderman; Michael Metzker; CT Caskey; John A Todd; J Fred Hess
Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family.
Biochemical and biophysical research communications 1998;248(3):879-88.
1998: Francesco Cucca; JV Goy; Y Kawaguchi; L Esposito; Marilyn E Merriman; AJ Wilson; Heather J Cordell; SC Bain; John A Todd
A male-female bias in type 1 diabetes and linkage to chromosome Xp in MHC HLA-DR3-positive patients.
Nature genetics 1998;19(3):301-2.
1998: Charles A Mein; L Esposito; M G Dunn; Gillian C L Johnson; Andrew Timms; JV Goy; Annabel N Smith; L Sebag-Montefiore; Marilyn E Merriman; AJ Wilson; L E Pritchard; Francesco Cucca; A H Barnett; SC Bain; John A Todd
A search for type 1 diabetes susceptibility genes in families from the United Kingdom.
Nature genetics 1998;19(3):297-300.
1998: PL Podolin; Paul Denny; N Armitage; christopher Lord; NJ Hill; ER Levy; Laurence B Peterson; John A Todd; Linda S Wicker; Paul A Lyons
Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse chromosome 3.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(4):283-6.
1998: Tony R Merriman; Iain A Eaves; Rebecca C J Twells; Marilyn E Merriman; Patrick Danoy; CE Muxworthy; Kara M Hunter; Roger D Cox; Francesco Cucca; PA McKinney; Julian P H Shield; JD Baum; Jaakko Tuomilehto; Eva Tuomilehto-Wolf; C Ionesco-Tirgoviste; Geir Joner; Erik Thorsby; DAG UNDLIEN; Flemming Pociot; Jørn Nerup; Kjersti S Ronningen; SC Bain; John A Todd
Transmission of haplotypes of microsatellite markers rather than single marker alleles in the mapping of a putative type 1 diabetes susceptibility gene (IDDM6).
Human molecular genetics 1998;7(3):517-24.
1998: H J Cordell; John A Todd; G Mark Lathrop
Mapping multiple linked quantitative trait loci in non-obese diabetic mice using a stepwise regression strategy.
Genetical research 1998;71(1):51-64.
1997: Simon T Bennett; AJ Wilson; L Esposito; N Bouzekri; DAG UNDLIEN; Francesco Cucca; Lorenza Nisticò; R Buzzetti; E Bosi; Flemming Pociot; Jørn Nerup; Anne Cambon-Thomsen; Alberto Pugliese; Julian P H Shield; PA McKinney; SC Bain; Constantin Polychronakos; John A Todd
Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele. The IMDIAB Group.
Nature genetics 1997;17(3):350-2.
1997: PL Podolin; Paul Denny; christopher Lord; NJ Hill; John A Todd; Laurence B Peterson; Linda S Wicker; Paul A Lyons
Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):1835-43.
1997: DM Waterworth; Simon T Bennett; Neda Gharani; Mark I McCarthy; S Hague; Sari Batty; Gerard S Conway; Davinia White; John A Todd; Stephen Franks; R Williamson
Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome.
Lancet 1997;349(9057):986-90.
1997: Paul Denny; christopher Lord; NJ Hill; J V Goy; ER Levy; PL Podolin; Laurence B Peterson; Linda S Wicker; John A Todd; Paul A Lyons
Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene.
Diabetes 1997;46(4):695-700.
1997: P Vafiadis; Simon T Bennett; John A Todd; J Nadeau; Rosemary Grabs; Cynthia G Goodyer; S Wickramasinghe; E Colle; Constantin Polychronakos
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.
Nature genetics 1997;15(3):289-92.
1996: Lorenza Nisticò; Raffaella Buzzetti; L E Pritchard; Bart J R Van der Auwera; Cristiano Giovannini; E Bosi; M T Larrad; M S Rios; C C Chow; C S Cockram; K Jacobs; Catherine H Mijovic; S C Bain; Anthony H Barnett; CL Vandewalle; Frans Schuit; Frans K Gorus; Roberto Tosi; Paolo Pozzilli; John A Todd
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry.
Human molecular genetics 1996;5(7):1075-80.
1996: J L Davies; Francesco Cucca; J V Goy; Z A Atta; Marilyn E Merriman; A Wilson; Anthony H Barnett; S C Bain; John A Todd
Saturation multipoint linkage mapping of chromosome 6q in type 1 diabetes.
Human molecular genetics 1996;5(7):1071-4.
1996: Simon T Bennett; AJ Wilson; Francesco Cucca; Jørn Nerup; Flemming Pociot; P A McKinney; A H Barnett; S C Bain; John A Todd
IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus.
Journal of autoimmunity 1996;9(3):415-21.
1996: J L Davies; Francesco Cucca; J V Goy; Z A Atta; Marilyn E Merriman; A Wilson; Anthony H Barnett; S C Bain; John A Todd
Linkage of chromosome 6 and type 1 diabetes.
DNA sequence : the journal of DNA sequencing and mapping 1996;7(1):25-6.
1996: Simon T Bennett; John A Todd
Human type 1 diabetes and the insulin gene: principles of mapping polygenes.
Annual review of genetics 1996;30():343-70.
1996: John A Todd; M Farrall
Panning for gold: genome-wide scanning for linkage in type 1 diabetes.
Human molecular genetics 1996;5 Spec No():1443-8.
1995: T R Merriman; John A Todd
Genetics of autoimmune disease.
Current opinion in immunology 1995;7(6):786-92.
1995: H J Cordell; John A Todd
Multifactorial inheritance in type 1 diabetes.
Trends in genetics : TIG 1995;11(12):499-504.
1995: H J Cordell; Y Kawaguchi; John A Todd; Martin Farrall
An extension of the Maximum Lod Score method to X-linked loci.
Annals of human genetics 1995;59(Pt 4):435-49.
1995: H J Cordell; John A Todd; Simon T Bennett; Y Kawaguchi; Martin Farrall
Two-locus maximum lod score analysis of a multifactorial trait: joint consideration of IDDM2 and IDDM4 with IDDM1 in type 1 diabetes.
American journal of human genetics 1995;57(4):920-34.
1995: John A Todd
Genetic analysis of type 1 diabetes using whole genome approaches.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(19):8560-5.
1995: christopher Lord; S K Bohlander; E A Hopes; Montague Carl; NJ Hill; Johannes B Prins; R J Renjilian; Laurence B Peterson; Linda S Wicker; John A Todd
Mapping the diabetes polygene Idd3 on mouse chromosome 3 by use of novel congenic strains.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(9):563-70.
1995: DAG UNDLIEN; Simon T Bennett; John A Todd; Hanne E Akselsen; I Ikäheimo; H Reijonen; Mikael Knip; Erik Thorsby; Kjersti S Rønningen
Insulin gene region-encoded susceptibility to IDDM maps upstream of the insulin gene.
Diabetes 1995;44(6):620-5.
1995: L E Pritchard; Y Kawaguchi; P W Reed; J B Copeman; J L Davies; Anthony H Barnett; S C Bain; John A Todd
Analysis of the CD3 gene region and type 1 diabetes: application of fluorescence-based technology to linkage disequilibrium mapping.
Human molecular genetics 1995;4(2):197-202.
1994: Linda S Wicker; John A Todd; J B Prins; PL Podolin; R J Renjilian; Laurence B Peterson
Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes.
The Journal of experimental medicine 1994;180(5):1705-13.
1994: E E Powell; Linda S Wicker; Laurence B Peterson; John A Todd
Allelic variation of the type 2 tumor necrosis factor receptor gene.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(11):726-7.
1994: Linda S Wicker; E H Leiter; John A Todd; R J Renjilian; E Peterson; P A Fischer; PL Podolin; M Zijlstra; Rudolf Jaenisch; Laurence B Peterson
Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes.
Diabetes 1994;43(3):500-4.
1994: NR Rodrigues; Richard J Cornall; P Chandler; E Simpson; Linda S Wicker; Laurence B Peterson; John A Todd
Mapping of an insulin-dependent diabetes locus, Idd9, in NOD mice to chromosome 4.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(3):167-70.
1994: John A Todd
Lawrence Lecture. The Emperor's new genes: 1993 RD Lawrence Lecture.
Diabetic medicine : a journal of the British Diabetic Association 1994;11(1):6-16.
1993: J B Prins; John A Todd; NR Rodrigues; S Ghosh; P M Hogarth; Linda S Wicker; E Gaffney; PL Podolin; P A Fischer; A Sirotina
Linkage on chromosome 3 of autoimmune diabetes and defective Fc receptor for IgG in NOD mice.
Science (New York, N.Y.) 1993;260(5108):695-8.
1993: Michael F Seldin; Johannes B Prins; NR Rodrigues; John A Todd; Miriam H Meisler
Encyclopedia of the mouse genome III. October 1993. Mouse chromosome 3.
Mammalian genome : official journal of the International Mammalian Genome Society 1993;4 Spec No():S47-57.
1993: John A Todd; P W Reed; Johannes B Prins; S C Bain; S M Palmer; H J Cordell; L E Pritchard; S Ghosh; Richard J Cornall; T J Aitman
Dissection of the pathophysiology of type 1 diabetes by genetic analysis.
Autoimmunity 1993;15 Suppl():16-7.
1992: John A Todd
La carte des microsatellites est arrivée! [The map of microsatellites has arrived!].
Human molecular genetics 1992;1(9):663-6.
1992: John A Todd; S C Bain
A practical approach to identification of susceptibility genes for IDDM.
Diabetes 1992;41(9):1029-34.
1992: C M Hearne; S Ghosh; John A Todd
Microsatellites for linkage analysis of genetic traits.
Trends in genetics : TIG 1992;8(8):288-94.
1992: Richard J Cornall; J M Friedman; John A Todd
Mouse microsatellites from a flow-sorted 4:6 Robertsonian chromosome.
Mammalian genome : official journal of the International Mammalian Genome Society 1992;3(11):620-4.
1992: John A Todd
Genetic analysis of susceptibility to type 1 diabetes.
Springer seminars in immunopathology 1992;14(1):33-58.
1991: John A Todd
A protective role of the environment in the development of type 1 diabetes?
Diabetic medicine : a journal of the British Diabetic Association 1991;8(10):906-10.
1991: C M Hearne; John A Todd
Trinucleotide repeat polymorphism at the CRYG1 locus.
Nucleic acids research 1991;19(19):5450.
1991: C M Hearne; John A Todd
Tetranucleotide repeat polymorphism at the HPRT locus.
Nucleic acids research 1991;19(19):5450.
1991: Richard J Cornall; Johannes B Prins; John A Todd; A Pressey; N H DeLarato; L S Wicker; Laurence B Peterson
Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/Ity/Bcg genes on chromosome 1.
Nature 1991;353(6341):262-5.
1991: Richard J Cornall; T J Aitman; C M Hearne; John A Todd
The generation of a library of PCR-analyzed microsatellite variants for genetic mapping of the mouse genome.
Genomics 1991;10(4):874-81.
1991: John A Todd; T J Aitman; Richard J Cornall; S Ghosh; J R Hall; C M Hearne; A M Knight; J M Love; M A McAleer; Johannes B Prins
Genetic analysis of autoimmune type 1 diabetes mellitus in mice.
Nature 1991;351(6327):542-7.
1991: John A Todd; T J Aitman; Richard J Cornall; S Ghosh; J Hall; C M Hearne; A Knight; J Love; M A McAleer; Johannes B Prins
Genetic analysis of a complex, multifactorial disease, autoimmune type 1 (insulin-dependent) diabetes.
Research in immunology 1991;142(5-6):483.
1991: C M Hearne; M A McAleer; J M Love; T J Aitman; Richard J Cornall; S Ghosh; A M Knight; Johannes B Prins; John A Todd
Additional microsatellite markers for mouse genome mapping.
Mammalian genome : official journal of the International Mammalian Genome Society 1991;1(4):273-82.
1991: T J Aitman; C M Hearne; M A McAleer; John A Todd
Mononucleotide repeats are an abundant source of length variants in mouse genomic DNA.
Mammalian genome : official journal of the International Mammalian Genome Society 1991;1(4):206-10.
1991: E Kendall; John A Todd; R Duncan Campbell
Molecular analysis of the MHC class II region in DR4, DR7, and DR9 haplotypes.
Immunogenetics 1991;34(6):349-57.
1990: J M Love; A M Knight; M A McAleer; John A Todd
Towards construction of a high resolution map of the mouse genome using PCR-analysed microsatellites.
Nucleic acids research 1990;18(14):4123-30.
1990: John A Todd; Y Fukui; T Kitagawa; T Sasazuki
The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(3):1094-8.
1990: John A Todd
The role of MHC class II genes in susceptibility to insulin-dependent diabetes mellitus.
Current topics in microbiology and immunology 1990;164():17-40.
1989: A N Roberts; Brendan Leighton; John A Todd; D Cockburn; Paul N Schofield; R Sutton; S Holt; Y Boyd; Anthony J Day; E A Foot
Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(24):9662-6.
1989: John A Todd; C Mijovic; J Fletcher; D Jenkins; A R Bradwell; A H Barnett
Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping.
Nature 1989;338(6216):587-9.
1989: John I Bell; John A Todd
HLA class II sequences infer mechanisms for major histocompatibility complex-associated disease susceptibility.
Molecular biology & medicine 1989;6(1):43-53.