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John Todd

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Raj S M; Howson J M M; Walker N M; Cooper J D; Smyth D J; Field S F; Stevens H E; Todd J A
No association of multiple type 2 diabetes loci with type 1 diabetes.
Todd John A
Stem cells and a cure for type 1 diabetes?
Marcovecchio M L; Dalton R N; Schwarze C P; Prevost A T; Neil H A W; Acerini C L; Barrett T; Cooper J D; Edge J; Shield J; Widmer B; Todd J A; Dunger D B
Ambulatory blood pressure measurements are related to albumin excretion and are predictive for risk of microalbuminuria in young people with type 1 diabetes.

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All Publications

2009: Raj S M; Howson J M M; Walker N M; Cooper J D; Smyth D J; Field S F; Stevens H E; Todd J A
No association of multiple type 2 diabetes loci with type 1 diabetes.
Diabetologia 2009;52(10):2109-16.
2009: Todd John A
Stem cells and a cure for type 1 diabetes?
Proceedings of the National Academy of Sciences of the United States of America 2009;106(37):15523-4.
2009: Marcovecchio M L; Dalton R N; Schwarze C P; Prevost A T; Neil H A W; Acerini C L; Barrett T; Cooper J D; Edge J; Shield J; Widmer B; Todd J A; Dunger D B
Ambulatory blood pressure measurements are related to albumin excretion and are predictive for risk of microalbuminuria in young people with type 1 diabetes.
Diabetologia 2009;52(6):1173-81.
2009: Nejentsev Sergey; Walker Neil; Riches David; Egholm Michael; Todd John A
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.
Science (New York, N.Y.) 2009;324(5925):387-9.
2009: Concannon Patrick; Chen Wei-Min; Julier Cécile; Morahan Grant; Akolkar Beena; Erlich Henry A; Hilner Joan E; Nerup Jørn; Nierras Concepcion; Pociot Flemming; Todd John A; Rich Stephen S;
Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium.
Diabetes 2009;58(4):1018-22.
2009: Plagnol Vincent; Smyth Deborah J; Todd John A; Clayton David G
Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13.
Biostatistics (Oxford, England) 2009;10(2):327-34.
2009: Fung E Y M G; Smyth D J; Howson J M M; Cooper J D; Walker N M; Stevens H; Wicker L S; Todd J A
Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.
Genes and immunity 2009;10(2):188-91.
2009: Rich S S; Akolkar B; Concannon P; Erlich H; Hilner J; Julier C; Morahan G; Nerup J; Nierras C; Pociot F; Todd J A
Results of the MHC fine mapping workshop.
Diabetes, obesity & metabolism 2009;11 Suppl 1():108-9.
2009: Howson J M M; Walker N M; Clayton D; Todd J A;
Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A.
Diabetes, obesity & metabolism 2009;11 Suppl 1():31-45.
2009: Maier Lisa M; Lowe Christopher E; Cooper Jason; Downes Kate; Anderson David E; Severson Christopher; Clark Pamela M; Healy Brian; Walker Neil; Aubin Cristin; Oksenberg Jorge R; Hauser Stephen L; Compston Alistair; Sawcer Stephen; De Jager Philip L; Wicker Linda S; Todd John A; Hafler David A
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.
PLoS genetics 2009;5(1):e1000322.
2009: Hafler J P; Maier L M; Cooper J D; Plagnol V; Hinks A; Simmonds M J; Stevens H E; Walker N M; Healy B; Howson J M M; Maisuria M; Duley S; Coleman G; Gough S C L; Worthington J; Kuchroo V K; Wicker L S; Todd J A
CD226 Gly307Ser association with multiple autoimmune diseases.
Genes and immunity 2009;10(1):5-10.
2009: Carr Edward J; Clatworthy Menna R; Lowe Christopher E; Todd John A; Wong Andrew; Vyse Timothy J; Kamesh Lavanya; Watts Richard A; Lyons Paul A; Smith Kenneth G C
Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis.
BMC medical genetics 2009;10():22.
2008: Smyth Deborah J; Plagnol Vincent; Walker Neil M; Cooper Jason D; Downes Kate; Yang Jennie H M; Howson Joanna M M; Stevens Helen; McManus Ross; Wijmenga Cisca; Heap Graham A; Dubois Patrick C; Clayton David G; Hunt Karen A; van Heel David A; Todd John A
Shared and distinct genetic variants in type 1 diabetes and celiac disease.
The New England journal of medicine 2008;359(26):2767-77.
2008: Cooper Jason D; Smyth Deborah J; Smiles Adam M; Plagnol Vincent; Walker Neil M; Allen James E; Downes Kate; Barrett Jeffrey C; Healy Barry C; Mychaleckyj Josyf C; Warram James H; Todd John A
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
Nature genetics 2008;40(12):1399-401.
2008: Maier Lisa M; Howlett Sarah K; Rainbow Kara M; Clark Jan; Howson Joanna M M; Todd John A; Wicker Linda S
NKG2D-RAE-1 receptor-ligand variation does not account for the NK cell defect in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):7073-80.
2008: Dunger David B; Todd John A
Prevention of type 1 diabetes: what next?
Lancet 2008;372(9651):1710-1.
2008: Concannon Patrick; Onengut-Gumuscu Suna; Todd John A; Smyth Deborah J; Pociot Flemming; Bergholdt Regine; Akolkar Beena; Erlich Henry A; Hilner Joan E; Julier Cécile; Morahan Grant; Nerup Jørn; Nierras Concepcion R; Chen Wei-Min; Rich Stephen S;
A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3.
Diabetes 2008;57(10):2858-61.
2008: Rainbow Dan B; Esposito Laura; Howlett Sarah K; Hunter Kara M; Todd John A; Peterson Laurence B; Wicker Linda S
Commonality in the genetic control of Type 1 diabetes in humans and NOD mice: variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species.
Biochemical Society transactions 2008;36(Pt 3):312-5.
2008: Field Sarah F; Nejentsev Sergey; Walker Neil M; Howson Joanna M M; Godfrey Lisa M; Jolley Jennifer D; Hardy Matthew P A; Todd John A
Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes.
Diabetes 2008;57(6):1753-6.
2008: Smyth Deborah J; Cooper Jason D; Howson Joanna M M; Walker Neil M; Plagnol Vincent; Stevens Helen; Clayton David G; Todd John A
PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes.
Diabetes 2008;57(6):1730-7.
2008: Vella A; Bouatia-Naji N; Heude B; Cooper J D; Lowe C E; Petry C; Ring S M; Dunger D B; Todd J A; Ong K K
Association analysis of the IGF1 gene with childhood growth, IGF-1 concentrations and type 1 diabetes.
Diabetologia 2008;51(5):811-5.
2008: Nejentsev Sergey; Thye Thorsten; Szeszko Jeffrey S; Stevens Helen; Balabanova Yanina; Chinbuah Amanua M; Hibberd Martin; van de Vosse Esther; Alisjahbana Bachti; van Crevel Reinout; Ottenhoff Tom H M; Png Eileen; Drobniewski Francis; Todd John A; Seielstad Mark; Horstmann Rolf D
Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations.
Nature genetics 2008;40(3):261-2; author reply 262-3.
2008: Horton Roger; Gibson Richard; Coggill Penny; Miretti Marcos; Allcock Richard J; Almeida Jeff; Forbes Simon; Gilbert James G R; Halls Karen; Harrow Jennifer L; Hart Elizabeth; Howe Kevin; Jackson David K; Palmer Sophie; Roberts Anne N; Sims Sarah; Stewart C Andrew; Traherne James A; Trevanion Steve; Wilming Laurens; Rogers Jane; de Jong Pieter J; Elliott John F; Sawcer Stephen; Todd John A; Trowsdale John; Beck Stephan
Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project.
Immunogenetics 2008;60(1):1-18.
2008: Ridgway William M; Peterson Laurence B; Todd John A; Rainbow Dan B; Healy Barry; Burren Oliver S; Wicker Linda S
Gene-gene interactions in the NOD mouse model of type 1 diabetes.
Advances in immunology 2008;100():151-75.
2008: Plagnol Vincent; Uz Elif; Wallace Chris; Stevens Helen; Clayton David; Ozcelik Tayfun; Todd John A
Extreme clonality in lymphoblastoid cell lines with implications for allele specific expression analyses.
PloS one 2008;3(8):e2966.
2007: Hunter Kara; Rainbow Dan; Plagnol Vincent; Todd John A; Peterson Laurence B; Wicker Linda S
Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(12):8341-9.
2007: Nejentsev Sergey; Howson Joanna M M; Walker Neil M; Szeszko Jeffrey; Field Sarah F; Stevens Helen E; Reynolds Pamela; Hardy Matthew; King Erna; Masters Jennifer; Hulme John; Maier Lisa M; Smyth Deborah; Bailey Rebecca; Cooper Jason D; Ribas Gloria; Campbell R Duncan; Clayton David G; Todd John A;
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A.
Nature 2007;450(7171):887-92.
2007: Bailey Rebecca; Cooper Jason D; Zeitels Lauren; Smyth Deborah J; Yang Jennie H M; Walker Neil M; Hyppönen Elina; Dunger David B; Ramos-Lopez Elizabeth; Badenhoop Klaus; Nejentsev Sergey; Todd John A
Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes.
Diabetes 2007;56(10):2616-21.
2007: Lowe Christopher E; Cooper Jason D; Brusko Todd; Walker Neil M; Smyth Deborah J; Bailey Rebecca; Bourget Kirsi; Plagnol Vincent; Field Sarah; Atkinson Mark; Clayton David G; Wicker Linda S; Todd John A
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.
Nature genetics 2007;39(9):1074-82.
2007: Simmonds Matthew J; Howson Joanna M M; Heward Joanne M; Carr-Smith Jackie; Franklyn Jayne A; Todd John A; Gough Stephen C L
A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect.
Human molecular genetics 2007;16(18):2149-53.
2007: Plagnol Vincent; Cooper Jason D; Todd John A; Clayton David G
A method to address differential bias in genotyping in large-scale association studies.
PLoS genetics 2007;3(5):e74.
2007: Brand Oliver J; Lowe Christopher E; Heward Joanne M; Franklyn Jayne A; Cooper Jason D; Todd John A; Gough Stephen C L
Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs.
Clinical endocrinology 2007;66(4):508-12.
2007: Howson J M M; Dunger D B; Nutland S; Stevens H; Wicker L S; Todd J A
A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene.
Diabetologia 2007;50(4):741-6.
2007: Szeszko Jeffrey S; Healy Barry; Stevens Helen; Balabanova Yanina; Drobniewski Francis; Todd John A; Nejentsev Sergey
Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis.
Human genetics 2007;121(2):155-60.
2007: Yamanouchi Jun; Rainbow Dan; Serra Pau; Howlett Sarah; Hunter Kara; Garner Valerie E S; Gonzalez-Munoz Andrea; Clark Jan; Veijola Riitta; Cubbon Rose; Chen Show-Ling; Rosa Raymond; Cumiskey Anne Marie; Serreze David V; Gregory Simon; Rogers Jane; Lyons Paul A; Healy Barry; Smink Luc J; Todd John A; Peterson Laurence B; Wicker Linda S; Santamaria Pere
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
Nature genetics 2007;39(3):329-37.
2007: Payne Felicity; Cooper Jason D; Walker Neil M; Lam Alex C; Smink Luc J; Nutland Sarah; Stevens Helen E; Hutchings Jayne; Todd John A
Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes.
Journal of leukocyte biology 2007;81(3):581-3.
2007: Hulbert Erin M; Smink Luc J; Adlem Ellen C; Allen James E; Burdick David B; Burren Oliver S; Cassen Victor M; Cavnor Christopher C; Dolman Geoffrey E; Flamez Daisy; Friery Karen F; Healy Barry C; Killcoyne Sarah A; Kutlu Burak; Schuilenburg Helen; Walker Neil M; Mychaleckyj Josyf; Eizirik Decio L; Wicker Linda S; Todd John A; Goodman Nathan
T1DBase: integration and presentation of complex data for type 1 diabetes research.
Nucleic acids research 2007;35(Database issue):D742-6.
2007: Field S F; Howson J M M; Smyth D J; Walker N M; Dunger D B; Todd J A
Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects.
Diabetologia 2007;50(1):212-3.
2007: Cooper Jason D; Smyth Deborah J; Bailey Rebecca; Payne Felicity; Downes Kate; Godfrey Lisa M; Masters Jennifer; Zeitels Lauren R; Vella Adrian; Walker Neil M; Todd John A
The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes.
BMC medical genetics 2007;8():71.
2007: Burke David F; Worth Catherine L; Priego Eva-Maria; Cheng Tammy; Smink Luc J; Todd John A; Blundell Tom L
Genome bioinformatic analysis of nonsynonymous SNPs.
BMC bioinformatics 2007;8():301.
2007: Nejentsev Sergey; Smink Luc J; Smyth Deborah; Bailey Rebecca; Lowe Christopher E; Payne Felicity; Masters Jennifer; Godfrey Lisa; Lam Alex; Burren Oliver; Stevens Helen; Nutland Sarah; Walker Neil M; Smith Anne; Twells Rebecca; Barratt Bryan J; Wright Charmain; French Lisa; Chen Yuan; Deloukas Panagiotis; Rogers Jane; Dunham Ian; Todd John A
Sequencing and association analysis of the type 1 diabetes-linked region on chromosome 10p12-q11.
BMC genetics 2007;8():24.
2006: Rich Stephen S; Concannon Patrick; Erlich Henry; Julier Cecile; Morahan Grant; Nerup Jorn; Pociot Flemming; Todd John A
The Type 1 Diabetes Genetics Consortium.
Annals of the New York Academy of Sciences 2006;1079():1-8.
2006: de Bakker Paul I W; McVean Gil; Sabeti Pardis C; Miretti Marcos M; Green Todd; Marchini Jonathan; Ke Xiayi; Monsuur Alienke J; Whittaker Pamela; Delgado Marcos; Morrison Jonathan; Richardson Angela; Walsh Emily C; Gao Xiaojiang; Galver Luana; Hart John; Hafler David A; Pericak-Vance Margaret; Todd John A; Daly Mark J; Trowsdale John; Wijmenga Cisca; Vyse Tim J; Beck Stephan; Murray Sarah Shaw; Carrington Mary; Gregory Simon; Deloukas Panos; Rioux John D
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC.
Nature genetics 2006;38(10):1166-72.
2006: Pask Rebecca; Cooper Jason D; Walker Neil M; Nutland Sarah; Hutchings Jayne; Dunger David B; Nejentsev Sergey; Todd John A
No evidence for a major effect of two common polymorphisms of the catalase gene in type 1 diabetes susceptibility.
Diabetes/metabolism research and reviews 2006;22(5):356-60.
2006: Maier Lisa M; Howson Joanna M M; Walker Neil; Spickett Gavin P; Jones Richard W; Ring Susan M; McArdle Wendy L; Lowe Christopher E; Bailey Rebecca; Payne Felicity; Todd John A; Strachan David P
Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes.
The Journal of allergy and clinical immunology 2006;117(6):1306-13.
2006: Smyth Deborah J; Cooper Jason D; Bailey Rebecca; Field Sarah; Burren Oliver; Smink Luc J; Guja Cristian; Ionescu-Tirgoviste Constantin; Widmer Barry; Dunger David B; Savage David A; Walker Neil M; Clayton David G; Todd John A
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.
Nature genetics 2006;38(6):617-9.
2006: Smyth Deborah J; Cooper Jason D; Lowe Christopher E; Nutland Sarah; Walker Neil M; Clayton David G; Todd John A
No evidence for association of OAS1 with type 1 diabetes in unaffected siblings or type 1 diabetic cases.
Diabetes 2006;55(5):1525-8.
2006: Barber Mathew J; Todd John A; Cordell Heather J
A multimarker regression-based test of linkage for affected sib-pairs at two linked loci.
Genetic epidemiology 2006;30(3):191-208.
2006: Szeszko Jeffrey S; Howson Joanna M M; Cooper Jason D; Walker Neil M; Twells Rebecca C J; Stevens Helen E; Nutland Sarah L; Todd John A
Analysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing.
Diabetes 2006;55(2):559-62.
2006: Traherne James A; Horton Roger; Roberts Anne N; Miretti Marcos M; Hurles Matthew E; Stewart C Andrew; Ashurst Jennifer L; Atrazhev Alexey M; Coggill Penny; Palmer Sophie; Almeida Jeff; Sims Sarah; Wilming Laurens G; Rogers Jane; de Jong Pieter J; Carrington Mary; Elliott John F; Sawcer Stephen; Todd John A; Trowsdale John; Beck Stephan
Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history.
PLoS genetics 2006;2(1):e9.
2006: Taniguchi Hidenori; Lowe Christopher E; Cooper Jason D; Smyth Deborah J; Bailey Rebecca; Nutland Sarah; Healy Barry C; Lam Alex C; Burren Oliver; Walker Neil M; Smink Luc J; Wicker Linda S; Todd John A
Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes.
BMC genetics 2006;7():22.
2006: Smyth Deborah J; Howson Joanna M M; Payne Felicity; Maier Lisa M; Bailey Rebecca; Holland Kieran; Lowe Christopher E; Cooper Jason D; Hulme John S; Vella Adrian; Dahlman Ingrid; Lam Alex C; Nutland Sarah; Walker Neil M; Twells Rebecca C J; Todd John A
Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.
BMC medical genetics 2006;7():20.
2006: Morris Gerard A J; Lowe Christopher E; Cooper Jason D; Payne Felicity; Vella Adrian; Godfrey Lisa; Hulme John S; Walker Neil M; Healy Barry C; Lam Alex C; Lyons Paul A; Todd John A
Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes.
BMC genetics 2006;7():12.
2005: Clayton David G; Walker Neil M; Smyth Deborah J; Pask Rebecca; Cooper Jason D; Maier Lisa M; Smink Luc J; Lam Alex C; Ovington Nigel R; Stevens Helen E; Nutland Sarah; Howson Joanna M M; Faham Malek; Moorhead Martin; Jones Hywel B; Falkowski Matthew; Hardenbol Paul; Willis Thomas D; Todd John A
Population structure, differential bias and genomic control in a large-scale, case-control association study.
Nature genetics 2005;37(11):1243-6.
2005: Concannon Patrick; Erlich Henry A; Julier Cecile; Morahan Grant; Nerup Jørn; Pociot Flemming; Todd John A; Rich Stephen S;
Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families.
Diabetes 2005;54(10):2995-3001.
2005: Maier L M; Cooper J D; Walker N; Smyth D J; Todd J A
Comment to: Biason-Lauber A, Boehm B, Lang-Muritano M et al. (2005) association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 48:900-905.
Diabetologia 2005;48(10):2180-2; author reply 2185-6.
2005: Cannons Jennifer L; Chamberlain Giselle; Howson Joanna; Smink Luc J; Todd John A; Peterson Laurence B; Wicker Linda S; Watts Tania H
Genetic and functional association of the immune signaling molecule 4-1BB (CD137/TNFRSF9) with type 1 diabetes.
Journal of autoimmunity 2005;25(1):13-20.
2005: Howson Joanna M M; Barratt Bryan J; Todd John A; Cordell Heather J
Comparison of population- and family-based methods for genetic association analysis in the presence of interacting loci.
Genetic epidemiology 2005;29(1):51-67.
2005: Payne Felicity; Smyth Deborah J; Pask Rebecca; Cooper Jason D; Masters Jennifer; Wang William Y S; Godfrey Lisa M; Bowden Georgina; Szeszko Jeffrey; Smink Luc J; Lam Alex C; Burren Oliver; Walker Neil M; Nutland Sarah; Rance Helen; Undlien Dag E; Rønningen Kjersti S; Guja Cristian; Ionescu-Tîrgoviste Constantin; Todd John A; Twells Rebecca C J
No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes.
Biochemical and biophysical research communications 2005;331(2):435-41.
2005: Vella Adrian; Cooper Jason D; Lowe Christopher E; Walker Neil; Nutland Sarah; Widmer Barry; Jones Richard; Ring Susan M; McArdle Wendy; Pembrey Marcus E; Strachan David P; Dunger David B; Twells Rebecca C J; Clayton David G; Todd John A
Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms.
American journal of human genetics 2005;76(5):773-9.
2005: Maier Lisa M; Chapman Juliet; Howson Joanna M M; Clayton David G; Pask Rebecca; Strachan David P; McArdle Wendy L; Twells Rebecca C J; Todd John A
No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.
American journal of human genetics 2005;76(3):517-21.
2005: Wang William Y S; Barratt Bryan J; Clayton David G; Todd John A
Genome-wide association studies: theoretical and practical concerns.
Nature reviews. Genetics 2005;6(2):109-18.
2005: Smyth Deborah J; Howson Joanna M M; Lowe Christopher E; Walker Neil M; Lam Alex C; Nutland Sarah; Hutchings Jayne; Tuomilehto-Wolf Eva; Tuomilehto Jaakko; Guja Cristian; Ionescu-Tîrgoviste Constantin; Undlien Dag E; Rønningen Kjersti S; Savage David; Dunger David B; Twells Rebecca C J; McArdle Wendy L; Strachan David P; Todd John A
Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes.
Nature genetics 2005;37(2):110-1; author reply 112-3.
2005: Smink Luc J; Helton Erin M; Healy Barry C; Cavnor Christopher C; Lam Alex C; Flamez Daisy; Burren Oliver S; Wang Yang; Dolman Geoffrey E; Burdick David B; Everett Vincent H; Glusman Gustavo; Laneri Davide; Rowen Lee; Schuilenburg Helen; Walker Neil M; Mychaleckyj Josyf; Wicker Linda S; Eizirik Decio L; Todd John A; Goodman Nathan
T1DBase, a community web-based resource for type 1 diabetes research.
Nucleic acids research 2005;33(Database issue):D544-9.
2005: Simmonds Matthew J; Howson Joanna M M; Heward Joanne M; Cordell Heather J; Foxall Helen; Carr-Smith Jackie; Gibson Sarah M; Walker Neil; Tomer Yaron; Franklyn Jayne A; Todd John A; Gough Stephen C L
Regression mapping of association between the human leukocyte antigen region and Graves disease.
American journal of human genetics 2005;76(1):157-63.
2005: Wicker Linda S; Clark Jan; Fraser Heather I; Garner Valerie E S; Gonzalez-Munoz Andrea; Healy Barry; Howlett Sarah; Hunter Kara; Rainbow Dan; Rosa Raymond L; Smink Luc J; Todd John A; Peterson Laurence B
Type 1 diabetes genes and pathways shared by humans and NOD mice.
Journal of autoimmunity 2005;25 Suppl():29-33.
2005: Wicker Linda S; Moule Carolyn L; Fraser Heather; Penha-Goncalves Carlos; Rainbow Dan; Garner Valerie E S; Chamberlain Giselle; Hunter Kara; Howlett Sarah; Clark Jan; Gonzalez-Munoz Andrea; Cumiskey Anne Marie; Tiffen Paul; Howson Joanna; Healy Barry; Smink Luc J; Kingsnorth Amanda; Lyons Paul A; Gregory Simon; Rogers Jane; Todd John A; Peterson Laurence B
Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse.
Novartis Foundation symposium 2005;267():57-65; discussion 65-75.
2005: Petry Clive J; Ong Ken K; Barratt Bryan J; Wingate Diane; Cordell Heather J; Ring Susan M; Pembrey Marcus E; Reik Wolf; Todd John A; Dunger David B;
Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans.
BMC genetics 2005;6(1):22.
2005: Maier Lisa M; Smyth Deborah J; Vella Adrian; Payne Felicity; Cooper Jason D; Pask Rebecca; Lowe Christopher; Hulme John; Smink Luc J; Fraser Heather; Moule Carolyn; Hunter Kara M; Chamberlain Giselle; Walker Neil; Nutland Sarah; Undlien Dag E; Rønningen Kjersti S; Guja Cristian; Ionescu-Tîrgoviste Constantin; Savage David A; Strachan David P; Peterson Laurence B; Todd John A; Wicker Linda S; Twells Rebecca C
Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes.
BMC genetics 2005;6(1):9.
2004: Motzo Costantino; Contu Daniela; Cordell Heather J; Lampis Rosanna; Congia Mauro; Marrosu Maria Giovanna; Todd John A; Devoto Marcella; Cucca Francesco
Heterogeneity in the magnitude of the insulin gene effect on HLA risk in type 1 diabetes.
Diabetes 2004;53(12):3286-91.
2004: Smyth Deborah; Cooper Jason D; Collins Joanne E; Heward Joanne M; Franklyn Jayne A; Howson Joanna M M; Vella Adrian; Nutland Sarah; Rance Helen E; Maier Lisa; Barratt Bryan J; Guja Cristian; Ionescu-Tîrgoviste Constantin; Savage David A; Dunger David B; Widmer Barry; Strachan David P; Ring Susan M; Walker Neil; Clayton David G; Twells Rebecca C J; Gough Stephen C L; Todd John A
Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.
Diabetes 2004;53(11):3020-3.
2004: Nejentsev Sergey; Cooper Jason D; Godfrey Lisa; Howson Joanna M M; Rance Helen; Nutland Sarah; Walker Neil M; Guja Cristian; Ionescu-Tirgoviste Constantin; Savage David A; Undlien Dag E; Rønningen Kjersti S; Tuomilehto-Wolf Eva; Tuomilehto Jaakko; Gillespie Kathleen M; Ring Susan M; Strachan David P; Widmer Barry; Dunger David; Todd John A
Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes.
Diabetes 2004;53(10):2709-12.
2004: Hulme John S; Barratt Bryan J; Twells Rebecca C J; Cooper Jason D; Lowe Chris E; Howson Joanna M M; Lam Alex C; Smink Luc J; Savage David A; Undlien Dag E; Guja Cristian; Ionescu-Tîirgoviste Constantin; Tuomilehto-Wolf Eva; Tuomilehto Jaakko; Todd John A
Association analysis of the lymphocyte-specific protein tyrosine kinase (LCK) gene in type 1 diabetes.
Diabetes 2004;53(9):2479-82.
2004: Koarada Syuichi; Wu Yuehong; Fertig Noreen; Sass David A; Nalesnik Michael; Todd John A; Lyons Paul A; Fenyk-Melody Judith; Rainbow Daniel B; Wicker Linda S; Peterson Laurence B; Ridgway William M
Genetic control of autoimmunity: protection from diabetes, but spontaneous autoimmune biliary disease in a nonobese diabetic congenic strain.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(4):2315-23.
2004: Lambert A Paul; Gillespie Kathleen M; Thomson Glenys; Cordell Heather J; Todd John A; Gale Edwin A M; Bingley Polly J
Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United Kingdom.
The Journal of clinical endocrinology and metabolism 2004;89(8):4037-43.
2004: Nejentsev Sergey; Godfrey Lisa; Snook Hywel; Rance Helen; Nutland Sarah; Walker Neil M; Lam Alex C; Guja Cristian; Ionescu-Tirgoviste Constantin; Undlien Dag E; Rønningen Kjersti S; Tuomilehto-Wolf Eva; Tuomilehto Jaakko; Newport Melanie J; Clayton David G; Todd John A
Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene.
Human molecular genetics 2004;13(15):1633-9.
2004: Pask Rebecca; Rance Helen E; Barratt Bryan J; Nutland Sarah; Smyth Deborah J; Sebastian Meera; Twells Rebecca C J; Smith Anne; Lam Alex C; Smink Luc J; Walker Neil M; Todd John A
Investigating the utility of combining phi29 whole genome amplification and highly multiplexed single nucleotide polymorphism BeadArray genotyping.
BMC biotechnology 2004;4():15.
2004: Zavattari Patrizia; Deidda Elisabetta; Pitzalis Maristella; Zoa Barbara; Moi Loredana; Lampis Rosanna; Contu Daniela; Motzo Costantino; Frongia Paola; Angius Efisio; Maioli Mario; Todd John A; Cucca Francesco
No association between variation of the FOXP3 gene and common type 1 diabetes in the Sardinian population.
Diabetes 2004;53(7):1911-4.
2004: Barratt Bryan J; Payne Felicity; Lowe Chris E; Hermann Robert; Healy Barry C; Harold Denise; Concannon Patrick; Gharani Neda; McCarthy Mark I; Olavesen Mark G; McCormack Rose; Guja Cristian; Ionescu-Tîrgoviste Constantin; Undlien Dag E; Rønningen Kjersti S; Gillespie Kathleen M; Tuomilehto-Wolf Eva; Tuomilehto Jaakko; Bennett Simon T; Clayton David G; Cordell Heather J; Todd John A
Remapping the insulin gene/IDDM2 locus in type 1 diabetes.
Diabetes 2004;53(7):1884-9.
2004: Wicker Linda S; Chamberlain Giselle; Hunter Kara; Rainbow Dan; Howlett Sarah; Tiffen Paul; Clark Jan; Gonzalez-Munoz Andrea; Cumiskey Anne Marie; Rosa Raymond L; Howson Joanna M; Smink Luc J; Kingsnorth Amanda; Lyons Paul A; Gregory Simon; Rogers Jane; Todd John A; Peterson Laurence B
Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):164-73.
2004: Stewart C Andrew; Horton Roger; Allcock Richard J N; Ashurst Jennifer L; Atrazhev Alexey M; Coggill Penny; Dunham Ian; Forbes Simon; Halls Karen; Howson Joanna M M; Humphray Sean J; Hunt Sarah; Mungall Andrew J; Osoegawa Kazutoyo; Palmer Sophie; Roberts Anne N; Rogers Jane; Sims Sarah; Wang Yu; Wilming Laurens G; Elliott John F; de Jong Pieter J; Sawcer Stephen; Todd John A; Trowsdale John; Beck Stephan
Complete MHC haplotype sequencing for common disease gene mapping.
Genome research 2004;14(6):1176-87.
2004: Lowe C E; Cooper J D; Chapman J M; Barratt B J; Twells R C J; Green E A; Savage D A; Guja C; Ionescu-Tîrgoviste C; Tuomilehto-Wolf E; Tuomilehto J; Todd J A; Clayton D G
Cost-effective analysis of candidate genes using htSNPs: a staged approach.
Genes and immunity 2004;5(4):301-5.
2004: Collins J E; Heward J M; Nithiyananthan R; Nejentsev S; Todd J A; Franklyn J A; Gough S C L
Lack of association of the vitamin D receptor gene with Graves' disease in UK Caucasians.
Clinical endocrinology 2004;60(5):618-24.
2004: Guja C; Guja L; Nutland S; Rance H; Sebastien M; Todd J A; Ionescu-Tirgoviste C
Type 1 diabetes genetic susceptibility encoded by HLA DQB1 genes in Romania.
Journal of cellular and molecular medicine 2004;8(2):249-56.
2004: Tait K F; Marshall T; Berman J; Carr-Smith J; Rowe B; Todd J A; Bain S C; Barnett A H; Gough S C L
Clustering of autoimmune disease in parents of siblings from the Type 1 diabetes Warren repository.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(4):358-62.
2004: Awomoyi A A; Nejentsev S; Richardson A; Hull J; Koch O; Podinovskaia M; Todd J A; McAdam K P W J; Blackwell J M; Kwiatkowski D; Newport M J
No association between interferon-gamma receptor-1 gene polymorphism and pulmonary tuberculosis in a Gambian population sample.
Thorax 2004;59(4):291-4.
2004: Vella Adrian; Howson Joanna M M; Barratt Bryan J; Twells Rebecca C J; Rance Helen E; Nutland Sarah; Tuomilehto-Wolf Eva; Tuomilehto Jaakko; Undlien Dag E; Rønningen Kjersti S; Guja Cristian; Ionescu-Tîrgoviste Constantin; Savage David A; Todd John A
Lack of association of the Ala(45)Thr polymorphism and other common variants of the NeuroD gene with type 1 diabetes.
Diabetes 2004;53(4):1158-61.
2004: Ong Ken K; Petry Clive J; Barratt Bryan J; Ring Susan; Cordell Heather J; Wingate Diane L; Pembrey Marcus E; Todd John A; Dunger David B;
Maternal-fetal interactions and birth order influence insulin variable number of tandem repeats allele class associations with head size at birth and childhood weight gain.
Diabetes 2004;53(4):1128-33.
2004: Tait K F; Collins J E; Heward J M; Eaves I; Snook H; Franklyn J A; Barnett A H; Todd J A; Maranian M; Compston A; Sawcer S; Gough S C L
Evidence for a Type 1 diabetes-specific mechanism for the insulin gene-associated IDDM2 locus rather than a general influence on autoimmunity.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(3):267-70.
2004: Eftychi Christina; Howson Joanna M M; Barratt Bryan J; Vella Adrian; Payne Felicity; Smyth Deborah J; Twells Rebecca C J; Walker Neil M; Rance Helen E; Tuomilehto-Wolf Eva; Tuomilehto Jaakko; Undlien Dag E; Rønningen Kjersti S; Guja Cristian; Ionescu-Tîirgoviste Constantin; Savage David A; Todd John A
Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes.
Diabetes 2004;53(3):870-3.
2004: Payne Felicity; Smyth Deborah J; Pask Rebecca; Barratt Bryan J; Cooper Jason D; Twells Rebecca C J; Walker Neil M; Lam Alex C; Smink Luc J; Nutland Sarah; Rance Helen E; Todd John A
Haplotype tag single nucleotide polymorphism analysis of the human orthologues of the rat type 1 diabetes genes Ian4 (Lyp/Iddm1) and Cblb.
Diabetes 2004;53(2):505-9.
2004: Burren Oliver S; Healy Barry C; Lam Alex C; Schuilenburg Helen; Dolman Geoffrey E; Everett Vincent H; Laneri Davide; Nutland Sarah; Rance Helen E; Payne Felicity; Smyth Deborah; Lowe Chris; Barratt Bryan J; Twells Rebecca C J; Rainbow Daniel B; Wicker Linda S; Todd John A; Walker Neil M; Smink Luc J
Development of an integrated genome informatics, data management and workflow infrastructure: a toolbox for the study of complex disease genetics.
Human genomics 2004;1(2):98-109.
2004: Guja C; Guja Loreta; Nutland Sarah; Rance Helen; Todd J A; Ionescu-Tîrgoviste C
Strong association of insulin gene INS-VNTR polymorphisms with type 1 diabetes in the Romanian population.
Romanian journal of internal medicine = Revue roumaine de médecine interne 2004;42(2):313-23.
2003: Wang William Y S; Todd John A
The usefulness of different density SNP maps for disease association studies of common variants.
Human molecular genetics 2003;12(23):3145-9.
2003: Nejentsev Sergey; Guja Cristian; McCormack Rose; Cooper Jason; Howson Joanna M M; Nutland Sarah; Rance Helen; Walker Neil; Undlien Dag; Ronningen Kjersti S; Tuomilehto-Wolf Eva; Tuomilehto Jaakko; Ionescu-Tirgoviste Constantin; Gale Edwin A M; Bingley Polly J; Gillespie Kathleen M; Savage David A; Carson Dennis J; Patterson Chris C; Maxwell A Peter; Todd John A
Association of intercellular adhesion molecule-1 gene with type 1 diabetes.
Lancet 2003;362(9397):1723-4.
2003: Maier L M; Twells R C J; Howson J M M; Lam A C; Clayton D G; Smyth D J; Savage D; Carson D; Patterson C C; Smink L J; Walker N M; Burren O S; Nutland S; Rance H; Tuomilehto-Wolf E; Tuomilehto J; Guja C; Ionescu-Tirgoviste C; Undlien D E; Rønningen K S; Cucca F; Todd J A
Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene.
Genes and immunity 2003;4(7):469-75.
2003: Shiono H; Roxanis I; Zhang W; Sims G P; Meager A; Jacobson L W; Liu J-L; Matthews I; Wong Y-L; Bonifati M; Micklem K; Stott D I; Todd J A; Beeson D; Vincent A; Willcox N
Scenarios for autoimmunization of T and B cells in myasthenia gravis.
Annals of the New York Academy of Sciences 2003;998():237-56.
2003: Twells Rebecca C J; Mein Charles A; Payne Felicity; Veijola Riitta; Gilbey Matthew; Bright Matthew; Timms Andrew; Nakagawa Yusuke; Snook Hywel; Nutland Sarah; Rance Helen E; Carr Philippa; Dudbridge Frank; Cordell Heather J; Cooper Jason; Tuomilehto-Wolf Eva; Tuomilehto Jaakko; Phillips Michael; Metzker Michael; Hess J Fred; Todd John A
Linkage and association mapping of the LRP5 locus on chromosome 11q13 in type 1 diabetes.
Human genetics 2003;113(2):99-105.
2003: Penha-Gonçalves Carlos; Moule Carolyn; Smink Luc J; Howson Joanna; Gregory Simon; Rogers Jane; Lyons Paul A; Suttie Joseph J; Lord Christopher J; Peterson Laurence B; Todd John A; Wicker Linda S
Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice.
Diabetes 2003;52(6):1551-6.
2003: Twells Rebecca C J; Mein Charles A; Phillips Michael S; Hess J Fred; Veijola Riitta; Gilbey Matthew; Bright Matthew; Metzker Michael; Lie Benedicte A; Kingsnorth Amanda; Gregory Edward; Nakagawa Yusuke; Snook Hywel; Wang William Y S; Masters Jennifer; Johnson Gillian; Eaves Iain; Howson Joanna M M; Clayton David; Cordell Heather J; Nutland Sarah; Rance Helen; Carr Philippa; Todd John A
Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene.
Genome research 2003;13(5):845-55.
2003: Wang William Y S; Cordell Heather J; Todd John A
Association mapping of complex diseases in linked regions: estimation of genetic effects and feasibility of testing rare variants.
Genetic epidemiology 2003;24(1):36-43.
2003: Brook Frances A; Evans Edward P; Lord Christopher J; Lyons Paul A; Rainbow Daniel B; Howlett Sarah K; Wicker Linda S; Todd John A; Gardner Richard L
The derivation of highly germline-competent embryonic stem cells containing NOD-derived genome.
Diabetes 2003;52(1):205-8.
2003: Chapman Juliet M; Cooper Jason D; Todd John A; Clayton David G
Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power.
Human heredity 2003;56(1-3):18-31.
2002: Contu Daniela; Morelli Laura; Zavattari Patrizia; Lampis Rosanna; Angius Efisio; Frongia Paola; Murru Daniela; Maioli Mario; Francalacci Paolo; Todd John A; Cucca Francesco
Sex-related bias and exclusion mapping of the nonrecombinant portion of chromosome Y in human type 1 diabetes in the isolated founder population of Sardinia.
Diabetes 2002;51(12):3573-6.
2002: Barratt B J; Payne F; Rance H E; Nutland S; Todd J A; Clayton D G
Identification of the sources of error in allele frequency estimations from pooled DNA indicates an optimal experimental design.
Annals of human genetics 2002;66(Pt 5-6):393-405.
2002: Johnson Gillian C L; Koeleman Bobby P C; Todd John A
Limitations of stratifying sib-pair data in common disease linkage studies: an example using chromosome 10p14-10q11 in type 1 diabetes.
American journal of medical genetics 2002;113(2):158-66.
2002: Johnson Gillian C L; Payne Felicity; Nutland Sarah; Stevens Helen; Tuomilehto-Wolf Eva; Tuomilehto Jaakko; Todd John A
A comprehensive, statistically powered analysis of GAD2 in type 1 diabetes.
Diabetes 2002;51(9):2866-70.
2002: Allcock R J N; Atrazhev A M; Beck S; de Jong P J; Elliott J F; Forbes S; Halls K; Horton R; Osoegawa K; Rogers J; Sawcer S; Todd J A; Trowsdale J; Wang Y; Williams S
The MHC haplotype project: a resource for HLA-linked association studies.
Tissue antigens 2002;59(6):520-1.
2002: Dahlman Ingrid; Eaves Iain A; Kosoy Roman; Morrison V Anne; Heward Joanne; Gough Stephen C L; Allahabadia Amit; Franklyn Jayne A; Tuomilehto Jaakko; Tuomilehto-Wolf Eva; Cucca Francesco; Guja Cristian; Ionescu-Tirgoviste Constantin; Stevens Helen; Carr Philippa; Nutland Sarah; McKinney Patricia; Shield Julian P; Wang William; Cordell Heather J; Walker Neil; Todd John A; Concannon Patrick
Parameters for reliable results in genetic association studies in common disease.
Nature genetics 2002;30(2):149-50.
2002: Guja C; Marshall S; Welsh K; Merriman M; Smith A; Todd J A; Ionescu-Tîrgoviste C
The study of CTLA-4 and vitamin D receptor polymorphisms in the Romanian type 1 diabetes population.
Journal of cellular and molecular medicine 2002;6(1):75-81.
2001: Lyons P A; Armitage N; Lord C J; Phillips M S; Todd J A; Peterson L B; Wicker L S
Mapping by genetic interaction: high-resolution congenic mapping of the type 1 diabetes loci Idd10 and Idd18 in the NOD mouse.
Diabetes 2001;50(11):2633-7.
2001: Ionescu-Tîrgoviste C; Guja C; Herr M; Cucca E; Welsh K; Bunce M; Marshall S; Todd J A
Low frequency of HLA DRB1*03 - DQB1*02 and DQB1*0302 haplotypes in Romania is consistent with the country's low incidence of Type I diabetes.
Diabetologia 2001;44 Suppl 3():B60-6.
2001: Johnson G C; Esposito L; Barratt B J; Smith A N; Heward J; Di Genova G; Ueda H; Cordell H J; Eaves I A; Dudbridge F; Twells R C; Payne F; Hughes W; Nutland S; Stevens H; Carr P; Tuomilehto-Wolf E; Tuomilehto J; Gough S C; Clayton D G; Todd J A
Haplotype tagging for the identification of common disease genes.
Nature genetics 2001;29(2):233-7.
2001: Cucca F; Lampis R; Congia M; Angius E; Nutland S; Bain S C; Barnett A H; Todd J A
A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins.
Human molecular genetics 2001;10(19):2025-37.
2001: Todd J A; Wicker L S
Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models.
Immunity 2001;15(3):387-95.
2001: Cucca F; Dudbridge F; Loddo M; Mulargia A P; Lampis R; Angius E; De Virgiliis S; Koeleman B P; Bain S C; Barnett A H; Gilchrist F; Cordell H; Welsh K; Todd J A
The HLA-DPB1--associated component of the IDDM1 and its relationship to the major loci HLA-DQB1, -DQA1, and -DRB1.
Diabetes 2001;50(5):1200-5.
2001: Cordell H J; Todd J A; Hill N J; Lord C J; Lyons P A; Peterson L B; Wicker L S; Clayton D G
Statistical modeling of interlocus interactions in a complex disease: rejection of the multiplicative model of epistasis in type 1 diabetes.
Genetics 2001;158(1):357-67.
2001: Zavattari P; Lampis R; Motzo C; Loddo M; Mulargia A; Whalen M; Maioli M; Angius E; Todd J A; Cucca F
Conditional linkage disequilibrium analysis of a complex disease superlocus, IDDM1 in the HLA region, reveals the presence of independent modifying gene effects influencing the type 1 diabetes risk encoded by the major HLA-DQB1, -DRB1 disease loci.
Human molecular genetics 2001;10(8):881-9.
2001: Twells R C; Metzker M L; Brown S D; Cox R; Garey C; Hammond H; Hey P J; Levy E; Nakagawa Y; Philips M S; Todd J A; Hess J F
The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13.
Genomics 2001;72(3):231-42.
2001: Lord C J; Howlett S; Lyons P A; Peterson L B; Wicker L S; Todd J A
The murine type 1 diabetes loci, Idd1, Idd3, Idd5, Idd9, and Idd17/10/18, do not control thymic CD4-CD8-/TCRalphabeta+ deficiency in the nonobese diabetic mouse.
Mammalian genome : official journal of the International Mammalian Genome Society 2001;12(2):175-6.
2000: Gillespie K M; Valovin S J; Saunby J; Hunter K M; Savage D A; Middleton D; Todd J A; Bingley P J; Gale E A
HLA class II typing of whole genome amplified mouth swab DNA.
Tissue antigens 2000;56(6):530-8.
2000: Zavattari P; Lampis R; Mulargia A; Loddo M; Angius E; Todd J A; Cucca F
Confirmation of the DRB1-DQB1 loci as the major component of IDDM1 in the isolated founder population of Sardinia.
Human molecular genetics 2000;9(20):2967-72.
2000: Lampis R; Morelli L; Congia M; Macis M D; Mulargia A; Loddo M; De Virgiliis S; Marrosu M G; Todd J A; Cucca F
The inter-regional distribution of HLA class II haplotypes indicates the suitability of the Sardinian population for case-control association studies in complex diseases.
Human molecular genetics 2000;9(20):2959-65.
2000: Zavattari P; Deidda E; Whalen M; Lampis R; Mulargia A; Loddo M; Eaves I; Mastio G; Todd J A; Cucca F
Major factors influencing linkage disequilibrium by analysis of different chromosome regions in distinct populations: demography, chromosome recombination frequency and selection.
Human molecular genetics 2000;9(20):2947-57.
2000: Hill N J; Lyons P A; Armitage N; Todd J A; Wicker L S; Peterson L B
NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.
Diabetes 2000;49(10):1744-7.
2000: Figueroa D J; Hess J F; Ky B; Brown S D; Sandig V; Hermanowski-Vosatka A; Twells R C; Todd J A; Austin C P
Expression of the type I diabetes-associated gene LRP5 in macrophages, vitamin A system cells, and the Islets of Langerhans suggests multiple potential roles in diabetes.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2000;48(10):1357-68.
2000: Siegmund T; Armitage N; Wicker L S; Peterson L B; Todd J A; Lyons P A
Analysis of the mouse CD30 gene: a candidate for the NOD mouse type 1 diabetes locus Idd9.2.
Diabetes 2000;49(9):1612-6.
2000: Lyons P A; Hancock W W; Denny P; Lord C J; Hill N J; Armitage N; Siegmund T; Todd J A; Phillips M S; Hess J F; Chen S L; Fischer P A; Peterson L B; Wicker L S
The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137.
Immunity 2000;13(1):107-15.
2000: Eaves I A; Merriman T R; Barber R A; Nutland S; Tuomilehto-Wolf E; Tuomilehto J; Cucca F; Todd J A
The genetically isolated populations of Finland and sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes.
Nature genetics 2000;25(3):320-3.
2000: Johnson G C; Todd J A
Strategies in complex disease mapping.
Current opinion in genetics & development 2000;10(3):330-4.
2000: Dudbridge F; Koeleman B P; Todd J A; Clayton D G
Unbiased application of the transmission/disequilibrium test to multilocus haplotypes.
American journal of human genetics 2000;66(6):2009-12.
2000: Koeleman B P; Herr M H; Zavattari P; Dudbridge F; March R; Campbell D; Barnett A H; Bain S C; Mulargia A P; Loddo M; Amos W; Cucca F; Todd J A
Conditional ETDT analysis of the human leukocyte antigen region in type 1 diabetes.
Annals of human genetics 2000;64(Pt 3):215-21.
2000: Koeleman B P; Dudbridge F; Cordell H J; Todd J A
Adaptation of the extended transmission/disequilibrium test to distinguish disease associations of multiple loci: the Conditional Extended Transmission/Disequilibrium Test.
Annals of human genetics 2000;64(Pt 3):207-13.
2000: Podolin P L; Wilusz M B; Cubbon R M; Pajvani U; Lord C J; Todd J A; Peterson L B; Wicker L S; Lyons P A
Differential glycosylation of interleukin 2, the molecular basis for the NOD Idd3 type 1 diabetes gene?
Cytokine 2000;12(5):477-82.
2000: Herr M; Dudbridge F; Zavattari P; Cucca F; Guja C; March R; Campbell R D; Barnett A H; Bain S C; Todd J A; Koeleman B P
Evaluation of fine mapping strategies for a multifactorial disease locus: systematic linkage and association analysis of IDDM1 in the HLA region on chromosome 6p21.
Human molecular genetics 2000;9(9):1291-301.
2000: Lyons P A; Armitage N; Argentina F; Denny P; Hill N J; Lord C J; Wilusz M B; Peterson L B; Wicker L S; Todd J A
Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping.
Genome research 2000;10(4):446-53.
2000: Mein C A; Barratt B J; Dunn M G; Siegmund T; Smith A N; Esposito L; Nutland S; Stevens H E; Wilson A J; Phillips M S; Jarvis N; Law S; de Arruda M; Todd J A
Evaluation of single nucleotide polymorphism typing with invader on PCR amplicons and its automation.
Genome research 2000;10(3):330-43.
2000: Zavattari P; Esposito L; Nutland S; Todd J A; Cucca F
Transmission-ratio distortion at Xp11.4-p21.1 in type 1 diabetes.
American journal of human genetics 2000;66(1):330-2.
1999: Todd J A
Interpretation of results from genetic studies of multifactorial diseases.
Lancet 1999;354 Suppl 1():SI15-6.
1999: Todd J A
From genome to aetiology in a multifactorial disease, type 1 diabetes.
BioEssays : news and reviews in molecular, cellular and developmental biology 1999;21(2):164-74.
1998: Esposito L; Hill N J; Pritchard L E; Cucca F; Muxworthy C; Merriman M E; Wilson A; Julier C; Delepine M; Tuomilehto J; Tuomilehto-Wolf E; Ionesco-Tirgoviste C; Nistico' L; Buzzetti R; Pozzilli P; Ferrari M; Bosi E; Pociot F; Nerup J; Bain S C; Todd J A
Genetic analysis of chromosome 2 in type 1 diabetes: analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster. IMDIAB Group.
Diabetes 1998;47(11):1797-9.
1998: Cucca F; Esposito L; Goy J V; Merriman M E; Wilson A J; Reed P W; Bain S C; Todd J A
Investigation of linkage of chromosome 8 to type 1 diabetes: multipoint analysis and exclusion mapping of human chromosome 8 in 593 affected sib-pair families from the U.K. and U.S.
Diabetes 1998;47(9):1525-7.
1998: Hey P J; Twells R C; Phillips M S; Yusuke Nakagawa; Brown S D; Kawaguchi Y; Cox R; Guochun Xie; Dugan V; Hammond H; Metzker M L; Todd J A; Hess J F
Cloning of a novel member of the low-density lipoprotein receptor family.
Gene 1998;216(1):103-11.
1998: Vafiadis P; Bennett S T; Todd J A; Grabs R; Polychronakos C
Divergence between genetic determinants of IGF2 transcription levels in leukocytes and of IDDM2-encoded susceptibility to type 1 diabetes.
The Journal of clinical endocrinology and metabolism 1998;83(8):2933-9.
1998: Nakagawa Y; Kawaguchi Y; Twells R C; Muxworthy C; Hunter K M; Wilson A; Merriman M E; Cox R D; Merriman T; Cucca F; McKinney P A; Shield J P; Tuomilehto J; Tuomilehto-Wolf E; Ionesco-Tirgoviste C; Nisticò L; Buzzetti R; Pozzilli P; Joner G; Thorsby E; Undlien D E; Pociot F; Nerup J; Rönningen K S; Bain S C; Todd J A;
Fine mapping of the diabetes-susceptibility locus, IDDM4, on chromosome 11q13.
American journal of human genetics 1998;63(2):547-56.
1998: Brown S D; Twells R C; Hey P J; Cox R D; Levy E R; Soderman A R; Metzker M L; Caskey C T; Todd J A; Hess J F
Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family.
Biochemical and biophysical research communications 1998;248(3):879-88.
1998: Cucca F; Goy J V; Kawaguchi Y; Esposito L; Merriman M E; Wilson A J; Cordell H J; Bain S C; Todd J A
A male-female bias in type 1 diabetes and linkage to chromosome Xp in MHC HLA-DR3-positive patients.
Nature genetics 1998;19(3):301-2.
1998: Mein C A; Esposito L; Dunn M G; Johnson G C; Timms A E; Goy J V; Smith A N; Sebag-Montefiore L; Merriman M E; Wilson A J; Pritchard L E; Cucca F; Barnett A H; Bain S C; Todd J A
A search for type 1 diabetes susceptibility genes in families from the United Kingdom.
Nature genetics 1998;19(3):297-300.
1998: Podolin P L; Denny P; Armitage N; Lord C J; Hill N J; Levy E R; Peterson L B; Todd J A; Wicker L S; Lyons P A
Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse chromosome 3.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(4):283-6.
1998: Merriman T R; Eaves I A; Twells R C; Merriman M E; Danoy P A; Muxworthy C E; Hunter K M; Cox R D; Cucca F; McKinney P A; Shield J P; Baum J D; Tuomilehto J; Tuomilehto-Wolf E; Ionesco-Tirgoviste C; Joner G; Thorsby E; Undlien D E; Pociot F; Nerup J; Ronningen K S; Bain S C; Todd J A
Transmission of haplotypes of microsatellite markers rather than single marker alleles in the mapping of a putative type 1 diabetes susceptibility gene (IDDM6).
Human molecular genetics 1998;7(3):517-24.
1998: Cordell H J; Todd J A; Lathrop G M
Mapping multiple linked quantitative trait loci in non-obese diabetic mice using a stepwise regression strategy.
Genetical research 1998;71(1):51-64.
1997: Bennett S T; Wilson A J; Esposito L; Bouzekri N; Undlien D E; Cucca F; Nisticò L; Buzzetti R; Bosi E; Pociot F; Nerup J; Cambon-Thomsen A; Pugliese A; Shield J P; McKinney P A; Bain S C; Polychronakos C; Todd J A
Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele. The IMDIAB Group.
Nature genetics 1997;17(3):350-2.
1997: Podolin P L; Denny P; Lord C J; Hill N J; Todd J A; Peterson L B; Wicker L S; Lyons P A
Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):1835-43.
1997: Waterworth D M; Bennett S T; Gharani N; McCarthy M I; Hague S; Batty S; Conway G S; White D; Todd J A; Franks S; Williamson R
Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome.
Lancet 1997;349(9057):986-90.
1997: Denny P; Lord C J; Hill N J; Goy J V; Levy E R; Podolin P L; Peterson L B; Wicker L S; Todd J A; Lyons P A
Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene.
Diabetes 1997;46(4):695-700.
1997: Vafiadis P; Bennett S T; Todd J A; Nadeau J; Grabs R; Goodyer C G; Wickramasinghe S; Colle E; Polychronakos C
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.
Nature genetics 1997;15(3):289-92.
1996: Nisticò L; Buzzetti R; Pritchard L E; Van der Auwera B; Giovannini C; Bosi E; Larrad M T; Rios M S; Chow C C; Cockram C S; Jacobs K; Mijovic C; Bain S C; Barnett A H; Vandewalle C L; Schuit F; Gorus F K; Tosi R; Pozzilli P; Todd J A
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry.
Human molecular genetics 1996;5(7):1075-80.
1996: Davies J L; Cucca F; Goy J V; Atta Z A; Merriman M E; Wilson A; Barnett A H; Bain S C; Todd J A
Saturation multipoint linkage mapping of chromosome 6q in type 1 diabetes.
Human molecular genetics 1996;5(7):1071-4.
1996: Bennett S T; Wilson A J; Cucca F; Nerup J; Pociot F; McKinney P A; Barnett A H; Bain S C; Todd J A
IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus.
Journal of autoimmunity 1996;9(3):415-21.
1996: Davies J L; Cucca F; Goy J V; Atta Z A; Merriman M E; Wilson A; Barnett A H; Bain S C; Todd J A
Linkage of chromosome 6 and type 1 diabetes.
DNA sequence : the journal of DNA sequencing and mapping 1996;7(1):25-6.
1996: Bennett S T; Todd J A
Human type 1 diabetes and the insulin gene: principles of mapping polygenes.
Annual review of genetics 1996;30():343-70.
1996: Todd J A; Farrall M
Panning for gold: genome-wide scanning for linkage in type 1 diabetes.
Human molecular genetics 1996;5 Spec No():1443-8.
1995: Merriman T R; Todd J A
Genetics of autoimmune disease.
Current opinion in immunology 1995;7(6):786-92.
1995: Cordell H J; Todd J A
Multifactorial inheritance in type 1 diabetes.
Trends in genetics : TIG 1995;11(12):499-504.
1995: Cordell H J; Kawaguchi Y; Todd J A; Farrall M
An extension of the Maximum Lod Score method to X-linked loci.
Annals of human genetics 1995;59(Pt 4):435-49.
1995: Cordell H J; Todd J A; Bennett S T; Kawaguchi Y; Farrall M
Two-locus maximum lod score analysis of a multifactorial trait: joint consideration of IDDM2 and IDDM4 with IDDM1 in type 1 diabetes.
American journal of human genetics 1995;57(4):920-34.
1995: Lord C J; Bohlander S K; Hopes E A; Montague C T; Hill N J; Prins J B; Renjilian R J; Peterson L B; Wicker L S; Todd J A
Mapping the diabetes polygene Idd3 on mouse chromosome 3 by use of novel congenic strains.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(9):563-70.
1995: Todd J A
Genetic analysis of type 1 diabetes using whole genome approaches.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(19):8560-5.
1995: Undlien D E; Bennett S T; Todd J A; Akselsen H E; Ikäheimo I; Reijonen H; Knip M; Thorsby E; Rønningen K S
Insulin gene region-encoded susceptibility to IDDM maps upstream of the insulin gene.
Diabetes 1995;44(6):620-5.
1995: Pritchard L E; Kawaguchi Y; Reed P W; Copeman J B; Davies J L; Barnett A H; Bain S C; Todd J A
Analysis of the CD3 gene region and type 1 diabetes: application of fluorescence-based technology to linkage disequilibrium mapping.
Human molecular genetics 1995;4(2):197-202.
1994: Wicker L S; Todd J A; Prins J B; Podolin P L; Renjilian R J; Peterson L B
Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes.
The Journal of experimental medicine 1994;180(5):1705-13.
1994: Powell E E; Wicker L S; Peterson L B; Todd J A
Allelic variation of the type 2 tumor necrosis factor receptor gene.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(11):726-7.
1994: Wicker L S; Leiter E H; Todd J A; Renjilian R J; Peterson E; Fischer P A; Podolin P L; Zijlstra M; Jaenisch R; Peterson L B
Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes.
Diabetes 1994;43(3):500-4.
1994: Rodrigues N R; Cornall R J; Chandler P; Simpson E; Wicker L S; Peterson L B; Todd J A
Mapping of an insulin-dependent diabetes locus, Idd9, in NOD mice to chromosome 4.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(3):167-70.
1994: Todd J A
Lawrence Lecture. The Emperor's new genes: 1993 RD Lawrence Lecture.
Diabetic medicine : a journal of the British Diabetic Association 1994;11(1):6-16.
1993: Prins J B; Todd J A; Rodrigues N R; Ghosh S; Hogarth P M; Wicker L S; Gaffney E; Podolin P L; Fischer P A; Sirotina A
Linkage on chromosome 3 of autoimmune diabetes and defective Fc receptor for IgG in NOD mice.
Science (New York, N.Y.) 1993;260(5108):695-8.
1993: Seldin M F; Prins J B; Rodrigues N R; Todd J A; Meisler M H
Encyclopedia of the mouse genome III. October 1993. Mouse chromosome 3.
Mammalian genome : official journal of the International Mammalian Genome Society 1993;4 Spec No():S47-57.
1993: Todd J A; Reed P W; Prins J B; Bain S C; Palmer S M; Cordell H J; Pritchard L E; Ghosh S; Cornall R J; Aitman T J
Dissection of the pathophysiology of type 1 diabetes by genetic analysis.
Autoimmunity 1993;15 Suppl():16-7.
1992: Todd J A
La carte des microsatellites est arrivée! [The map of microsatellites has arrived!]
Human molecular genetics 1992;1(9):663-6.
1992: Todd J A; Bain S C
A practical approach to identification of susceptibility genes for IDDM.
Diabetes 1992;41(9):1029-34.
1992: Hearne C M; Ghosh S; Todd J A
Microsatellites for linkage analysis of genetic traits.
Trends in genetics : TIG 1992;8(8):288-94.
1992: Cornall R J; Friedman J M; Todd J A
Mouse microsatellites from a flow-sorted 4:6 Robertsonian chromosome.
Mammalian genome : official journal of the International Mammalian Genome Society 1992;3(11):620-4.
1992: Todd J A
Genetic analysis of susceptibility to type 1 diabetes.
Springer seminars in immunopathology 1992;14(1):33-58.
1991: Todd J A
A protective role of the environment in the development of type 1 diabetes?
Diabetic medicine : a journal of the British Diabetic Association 1991;8(10):906-10.
1991: Hearne C M; Todd J A
Trinucleotide repeat polymorphism at the CRYG1 locus.
Nucleic acids research 1991;19(19):5450.
1991: Hearne C M; Todd J A
Tetranucleotide repeat polymorphism at the HPRT locus.
Nucleic acids research 1991;19(19):5450.
1991: Cornall R J; Prins J B; Todd J A; Pressey A; DeLarato N H; Wicker L S; Peterson L B
Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/Ity/Bcg genes on chromosome 1.
Nature 1991;353(6341):262-5.
1991: Cornall R J; Aitman T J; Hearne C M; Todd J A
The generation of a library of PCR-analyzed microsatellite variants for genetic mapping of the mouse genome.
Genomics 1991;10(4):874-81.
1991: Todd J A; Aitman T J; Cornall R J; Ghosh S; Hall J; Hearne C M; Knight A; Love J; McAleer M A; Prins J B
Genetic analysis of a complex, multifactorial disease, autoimmune type 1 (insulin-dependent) diabetes.
Research in immunology 1991;142(5-6):483.
1991: Todd J A; Aitman T J; Cornall R J; Ghosh S; Hall J R; Hearne C M; Knight A M; Love J M; McAleer M A; Prins J B
Genetic analysis of autoimmune type 1 diabetes mellitus in mice.
Nature 1991;351(6327):542-7.
1991: Hearne C M; McAleer M A; Love J M; Aitman T J; Cornall R J; Ghosh S; Knight A M; Prins J B; Todd J A
Additional microsatellite markers for mouse genome mapping.
Mammalian genome : official journal of the International Mammalian Genome Society 1991;1(4):273-82.
1991: Aitman T J; Hearne C M; McAleer M A; Todd J A
Mononucleotide repeats are an abundant source of length variants in mouse genomic DNA.
Mammalian genome : official journal of the International Mammalian Genome Society 1991;1(4):206-10.
1991: Kendall E; Todd J A; Campbell R D
Molecular analysis of the MHC class II region in DR4, DR7, and DR9 haplotypes.
Immunogenetics 1991;34(6):349-57.
1990: Love J M; Knight A M; McAleer M A; Todd J A
Towards construction of a high resolution map of the mouse genome using PCR-analysed microsatellites.
Nucleic acids research 1990;18(14):4123-30.
1990: Todd J A; Fukui Y; Kitagawa T; Sasazuki T
The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(3):1094-8.
1990: Todd J A
The role of MHC class II genes in susceptibility to insulin-dependent diabetes mellitus.
Current topics in microbiology and immunology 1990;164():17-40.
1989: Roberts A N; Leighton B; Todd J A; Cockburn D; Schofield P N; Sutton R; Holt S; Boyd Y; Day A J; Foot E A
Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(24):9662-6.
1989: Todd J A; Mijovic C; Fletcher J; Jenkins D; Bradwell A R; Barnett A H
Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping.
Nature 1989;338(6216):587-9.
1989: Bell J I; Todd J A
HLA class II sequences infer mechanisms for major histocompatibility complex-associated disease susceptibility.
Molecular biology & medicine 1989;6(1):43-53.

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