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Arrel Toews

Research Profile

Living Beings

Anatomy

Chemicals & Drugs

Physiology

Axonal Transport

Disorders

Demyelinating Diseases

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Publications

TOP 3
Susan H Brunssen; Christopher A McPherson; Sheryl S Moy; Arrel D Toews; G Jean Harry
Interleukin-6 (IL-6) receptor/IL-6 fusion protein (Hyper IL-6) effects on the neonatal mouse brain: possible role for IL-6 trans-signaling in brain development and functional neurobehavioral outcomes.
Carla Taveggia; Pratik Thaker; Ashley Petrylak; Gregg L Caporaso; Arrel D Toews; Douglas L Falls; Steven Einheber; James L Salzer
Type III neuregulin-1 promotes oligodendrocyte myelination.
Jeffrey L Mason; Arrel D Toews; Janell Hostettler; Pierre Morell; Kinuko Suzuki; James E Goldman; Glenn K Matsushima
Oligodendrocytes and progenitors become progressively depleted within chronically demyelinated lesions.

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All Publications

2013: Susan H Brunssen; Christopher A McPherson; Sheryl S Moy; Arrel D Toews; G Jean Harry
Interleukin-6 (IL-6) receptor/IL-6 fusion protein (Hyper IL-6) effects on the neonatal mouse brain: possible role for IL-6 trans-signaling in brain development and functional neurobehavioral outcomes.
Brain, behavior, and immunity 2013;27(1):42-53.
2008: Carla Taveggia; Pratik Thaker; Ashley Petrylak; Gregg L Caporaso; Arrel D Toews; Douglas L Falls; Steven Einheber; James L Salzer
Type III neuregulin-1 promotes oligodendrocyte myelination.
Glia 2008;56(3):284-93.
2004: Jeffrey L Mason; Arrel D Toews; Janell Hostettler; Pierre Morell; Kinuko Suzuki; James E Goldman; Glenn K Matsushima
Oligodendrocytes and progenitors become progressively depleted within chronically demyelinated lesions.
The American journal of pathology 2004;164(5):1673-82.
2003: Helga Jurevics; Janell Hostettler; Deanne W Sammond; Klaus-Armin Nave; Arrel D Toews; Pierre Morell
Normal metabolism but different physical properties of myelin from mice deficient in proteolipid protein.
Journal of neuroscience research 2003;71(6):826-34.
2002: Helga Jurevics; Carrie Largent; Janell Hostettler; Deanne W Sammond; Glenn K Matsushima; Amber Kleindienst; Arrel D Toews; Pierre Morell
Alterations in metabolism and gene expression in brain regions during cuprizone-induced demyelination and remyelination.
Journal of neurochemistry 2002;82(1):126-36.
2001: Helga Jurevics; Janell Hostettler; E D Muse; Deanne W Sammond; Glenn K Matsushima; Arrel D Toews; Pierre Morell
Cerebroside synthesis as a measure of the rate of remyelination following cuprizone-induced demyelination in brain.
Journal of neurochemistry 2001;77(4):1067-76.
2001: E D Muse; Helga Jurevics; Arrel D Toews; Glenn K Matsushima; Pierre Morell
Parameters related to lipid metabolism as markers of myelination in mouse brain.
Journal of neurochemistry 2001;76(1):77-86.
2000: Helga Jurevics; Janell Hostettler; C Barrett; Pierre Morell; Arrel D Toews
Diurnal and dietary-induced changes in cholesterol synthesis correlate with levels of mRNA for HMG-CoA reductase.
Journal of lipid research 2000;41(7):1048-54.
2000: JF Goodrum; K A Fowler; Janell Hostettler; Arrel D Toews
Peripheral nerve regeneration and cholesterol reutilization are normal in the low-density lipoprotein receptor knockout mouse.
Journal of neuroscience research 2000;59(4):581-6.
1998: Pierre Morell; C V Barrett; Jeffrey L Mason; Arrel D Toews; Janell Hostettler; G W Knapp; Glenn K Matsushima
Gene expression in brain during cuprizone-induced demyelination and remyelination.
Molecular and cellular neurosciences 1998;12(4-5):220-7.
1998: Q Fu; JF Goodrum; C Hayes; Janell Hostettler; Arrel D Toews; Pierre Morell
Control of cholesterol biosynthesis in Schwann cells.
Journal of neurochemistry 1998;71(2):549-55.
1998: Arrel D Toews; C Barrett; Pierre Morell
Monocyte chemoattractant protein 1 is responsible for macrophage recruitment following injury to sciatic nerve.
Journal of neuroscience research 1998;53(2):260-7.
1998: Helga Jurevics; Thomas W Bouldin; Arrel D Toews; Pierre Morell
Regenerating sciatic nerve does not utilize circulating cholesterol.
Neurochemical research 1998;23(3):401-6.
1998: Arrel D Toews; G J Harry; K B Lowrey; D L Morgan; Robert C Sills
Carbon disulfide neurotoxicity in rats: IV. Increased mRNA expression of low-affinity nerve growth factor receptor--a sensitive and early indicator of PNS damage.
Neurotoxicology 1998;19(1):109-16.
1997: Arrel D Toews; E B Roe; JF Goodrum; Thomas W Bouldin; J Weaver; N D Goines; Pierre Morell
Tellurium causes dose-dependent coordinate down-regulation of myelin gene expression.
Brain research. Molecular brain research 1997;49(1-2):113-9.
1997: Arrel D Toews; Janell Hostettler; C Barrett; Pierre Morell
Alterations in gene expression associated with primary demyelination and remyelination in the peripheral nervous system.
Neurochemical research 1997;22(10):1271-80.
1996: Arrel D Toews; H Jurevics; Janell Hostettler; E B Roe; Pierre Morell
Tissue-specific coordinate regulation of enzymes of cholesterol biosynthesis: sciatic nerve versus liver.
Journal of lipid research 1996;37(12):2502-9.
1996: Pierre Morell; Arrel D Toews
Schwann cells as targets for neurotoxicants.
Neurotoxicology 1996;17(3-4):685-95.
1995: M Wagner; Arrel D Toews; Pierre Morell
Tellurite specifically affects squalene epoxidase: investigations examining the mechanism of tellurium-induced neuropathy.
Journal of neurochemistry 1995;64(5):2169-76.
1995: M D Roberson; Arrel D Toews; Thomas W Bouldin; J Weaver; N D Goines; Pierre Morell
NGFR-mRNA expression in sciatic nerve: a sensitive indicator of early stages of axonopathy.
Brain research. Molecular brain research 1995;28(2):231-8.
1995: R D Venezie; Arrel D Toews; Pierre Morell
Macrophage recruitment in different models of nerve injury: lysozyme as a marker for active phagocytosis.
Journal of neuroscience research 1995;40(1):99-107.
1994: Pierre Morell; Arrel D Toews; M Wagner; JF Goodrum
Gene expression during tellurium-induced primary demyelination.
Neurotoxicology 1994;15(1):171-80.
1992: M D Roberson; Arrel D Toews; JF Goodrum; Pierre Morell
Neurofilament and tubulin mRNA expression in Schwann cells.
Journal of neuroscience research 1992;33(1):156-62.
1992: Arrel D Toews; Ian R Griffiths; E Kyriakides; JF Goodrum; C E Eckermann; Pierre Morell; Christine E Thomson
Primary demyelination induced by exposure to tellurium alters Schwann cell gene expression: a model for intracellular targeting of NGF receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1992;12(9):3676-87.
1991: Arrel D Toews; JF Goodrum; S Y Lee; C Eckermann; Pierre Morell
Tellurium-induced alterations in 3-hydroxy-3-methylglutaryl-CoA reductase gene expression and enzyme activity: differential effects in sciatic nerve and liver suggest tissue-specific regulation of cholesterol synthesis.
Journal of neurochemistry 1991;57(6):1902-6.
1991: M Wagner-Recio; Arrel D Toews; Pierre Morell
Tellurium blocks cholesterol synthesis by inhibiting squalene metabolism: preferential vulnerability to this metabolic block leads to peripheral nervous system demyelination.
Journal of neurochemistry 1991;57(6):1891-901.
1991: Arrel D Toews; C E Eckermann; M D Roberson; S Y Lee; Pierre Morell
Primary demyelination induced by exposure to tellurium alters mRNA levels for nerve growth factor receptor, SCIP, 2',3'-cyclic nucleotide 3'-phosphodiesterase, and myelin proteolipid protein in rat sciatic nerve.
Brain research. Molecular brain research 1991;11(3-4):321-5.
1990: Arrel D Toews; S Y Lee; Brian Popko; Pierre Morell
Tellurium-induced neuropathy: a model for reversible reductions in myelin protein gene expression.
Journal of neuroscience research 1990;26(4):501-7.
1990: Pierre Morell; M D Roberson; G Meissner; Arrel D Toews
Myelin: from electrical insulator to ion channels.
Progress in clinical and biological research 1990;336():1-23.
1989: G Jean Harry; JF Goodrum; Thomas W Bouldin; Arrel D Toews; Pierre Morell
Acrylamide-induced increases in deposition of axonally transported glycoproteins in rat sciatic nerve.
Journal of neurochemistry 1989;52(4):1240-7.
1989: F V White; Arrel D Toews; JF Goodrum; D L Novicki; Thomas W Bouldin; Pierre Morell
Lipid metabolism during early stages of Wallerian degeneration in the rat sciatic nerve.
Journal of neurochemistry 1989;52(4):1085-92.
1989: G Jean Harry; JF Goodrum; Thomas W Bouldin; M Wagner-Recio; Arrel D Toews; Pierre Morell
Tellurium-induced neuropathy: metabolic alterations associated with demyelination and remyelination in rat sciatic nerve.
Journal of neurochemistry 1989;52(3):938-45.
1988: Arrel D Toews; F V White; Pierre Morell
Metabolism of functional groups modifying the CNS myelin-associated glycoprotein.
Journal of neurochemistry 1988;51(5):1646-50.
1988: Arrel D Toews; J Lagarde; N D Goines; Thomas W Bouldin
Early metabolic responses of retinal neurons to trimethyltin intoxication.
Neurochemical pathology 1988;8(2):63-78.
1988: Arrel D Toews; R Armstrong; R Ray; Robert Gould; Pierre Morell
Deposition and transfer of axonally transported phospholipids in rat sciatic nerve.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(2):593-601.
1987: R Armstrong; Arrel D Toews; Pierre Morell
Rapid axonal transport in focally demyelinated sciatic nerve.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1987;7(12):4044-53.
1987: R Armstrong; Arrel D Toews; Pierre Morell
Axonal transport through nodes of Ranvier.
Brain research 1987;412(1):196-9.
1987: G Jean Harry; JF Goodrum; Arrel D Toews; Pierre Morell
Axonal transport characteristics of gangliosides in sensory axons of rat sciatic nerve.
Journal of neurochemistry 1987;48(5):1529-36.
1987: Arrel D Toews; H R Fischer; JF Goodrum; S Windes; Pierre Morell
Metabolism of phosphate and sulfate groups modifying the P0 protein of peripheral nervous system myelin.
Journal of neurochemistry 1987;48(3):883-7.
1986: Arrel D Toews; R B Ray; N D Goines; Thomas W Bouldin
Increased synthesis of membrane macromolecules is an early response of retinal neurons to trimethyltin intoxication.
Brain research 1986;398(2):298-304.
1986: F V White; Arrel D Toews; Pierre Morell
Developmental pattern for phosphatidylserine decarboxylase in rat brain.
Journal of neurochemistry 1986;46(4):1200-6.
1985: R Armstrong; Arrel D Toews; R B Ray; Pierre Morell
Retrograde axonal transport of endogenous phospholipids in rat sciatic nerve.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1985;5(4):965-9.
1985: G Jean Harry; Arrel D Toews; M R Krigman; Pierre Morell
The effect of lead toxicity and milk deprivation of myelination in the rat.
Toxicology and applied pharmacology 1985;77(3):458-64.
1985: C M Gammon; JF Goodrum; Arrel D Toews; A Okabe; Pierre Morell
Axonal transport of glycoconjugates in the rat visual system.
Journal of neurochemistry 1985;44(2):376-87.
1984: J Sedzik; Arrel D Toews; A E Blaurock; Pierre Morell
Resistance to disruption of multilamellar fragments of central nervous system myelin.
Journal of neurochemistry 1984;43(5):1415-20.
1983: Arrel D Toews; W D Blaker; D J Thomas; J J Gaynor; M R Krigman; P Mushak; Pierre Morell
Myelin deficits produced by early postnatal exposure to inorganic lead or triethyltin are persistent.
Journal of neurochemistry 1983;41(3):816-22.
1983: Arrel D Toews; Barry Saunders; W D Blaker; Pierre Morell
Differences in the kinetics of axonal transport for individual lipid classes in rat sciatic nerve.
Journal of neurochemistry 1983;40(2):555-62.
1982: Arrel D Toews; Barry Saunders; Pierre Morell
Axonal transport and metabolism of glycoproteins in rat sciatic nerve.
Journal of neurochemistry 1982;39(5):1348-55.
1981: Arrel D Toews; Pierre Morell
Turnover of axonally transported phospholipids in nerve endings of retinal ganglion cells.
Journal of neurochemistry 1981;37(5):1316-23.
1981: Arrel D Toews; Agnaldo José do Nascimento; M Alvarez; J H Duarte; AP Campello
Sugar derivatives and liver mitochondria. V - Effect of 6-O-benzoyl-3-deoxy-3-fluoro-1,2-O-isopropylidene-alpha-D-glucofuranose.
Research communications in chemical pathology and pharmacology 1981;31(2):267-74.
1980: Arrel D Toews; S S Padilla; L J Roger; Pierre Morell
Axonal transport of glycerophospholipids following intracerebral injection of glycerol into substantia nigra or lateral geniculate body.
Neurochemical research 1980;5(11):1175-83.
1980: Arrel D Toews; M R Krigman; D J Thomas; Pierre Morell
Effect of inorganic lead exposure on myelination in the rat.
Neurochemical research 1980;5(6):605-16.
1980: Arrel D Toews; A G de la Rocha
Oropharyngeal sepsis with endothoracic spread.
Canadian journal of surgery. Journal canadien de chirurgie 1980;23(3):265-8.
1980: W D Blaker; Arrel D Toews; Pierre Morell
Cholesterol is a component of the rapid phase of axonal transport.
Journal of neurobiology 1980;11(3):243-50.
1980: Arrel D Toews; J S King; D Yashon; L A Horrocks
Myelin and microsomes from rhesus monkey spinal cord: isolation and effects of trauma.
Neurological research 1980;1(3):271-9.
1979: S S Padilla; L J Roger; Arrel D Toews; J F Goodrum; Pierre Morell
Comparison of proteins transported in different tracts of the central nervous system.
Brain research 1979;176(2):407-11.
1979: J F Goodrum; Arrel D Toews; Pierre Morell
Axonal transport and metabolism of [3H]fucose- and [35S]-sulfate-labeled macromolecules in the rat visual system.
Brain research 1979;176(2):255-72.
1979: Arrel D Toews; J F Goodrum; Pierre Morell
Axonal transport of phospholipids in rat visual system.
Journal of neurochemistry 1979;32(4):1165-73.
1978: Arrel D Toews; A Kolber; J Hayward; M R Krigman; Pierre Morell
Experimental lead encephalopathy in the suckling rat: concentration of lead in cellular fractions enriched in brain capillaries.
Brain research 1978;147(1):131-8.
1977: R V Dorman; Arrel D Toews; L A Horrocks
Plasmalogenase activities in neuronal perikarya, astroglia, and oligodendroglia isolated from bovine brain.
Journal of lipid research 1977;18(1):115-7.
1976: Arrel D Toews; L A Horrocks
Developmental and aging changes in protein concentration and 2',3'-cyclic nucleosidemonophosphate phosphodiesterase activity (EC 3.1.4.16) in human cerebral white and gray matter and spinal cord.
Journal of neurochemistry 1976;27(2):545-50.
1976: Arrel D Toews; L A Horrocks; J S King
Simultaneous isolation of purified microsomal and myelin fractions from rat spinal cord.
Journal of neurochemistry 1976;27(1):25-31.
1976: L A Horrocks; Arrel D Toews; D K Thompson; J Y Chin
Synthesis and turnover of brain phosphoglycerides- results, methods of calculation and interpretation.
Advances in experimental medicine and biology 1976;72():37-54.
1973: L A Horrocks; Arrel D Toews; D Yashon; G E Locke
Changes in myelin following trauma of the spinal cord in monkeys.
Neurobiology 1973;3(4):256-63.