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David Toft
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Chemicals & Drugs
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24
Sullivan, William
12
Felts, Sara
10
Smith, David
10
Stensgard, Bridget
6
Chadli, Ahmed
6
Erlichman, Charles
5
Conneely, Orla
5
O'Malley, Bert
5
Owen, Barbara
5
Sullivan, William
4
Karnitz, Larry
3
Schulte, TW
3
Neckers, Leonard
3
Horwitz, Kathryn
3
Johnson, BD
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All Publications
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2008: McCollum Andrea K; Lukasiewicz Kara B; Teneyck Cynthia J; Lingle Wilma L; Toft David O; Erlichman Charles
Cisplatin abrogates the geldanamycin-induced heat shock response.
Molecular cancer therapeutics 2008;7(10):3256-64.
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2008: McCollum Andrea K; TenEyck Cynthia J; Stensgard Bridget; Morlan Bruce W; Ballman Karla V; Jenkins Robert B; Toft David O; Erlichman Charles
P-Glycoprotein-mediated resistance to Hsp90-directed therapy is eclipsed by the heat shock response.
Cancer research 2008;68(18):7419-27.
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2008: Moffatt Nela S Cintrón; Bruinsma Elizabeth; Uhl Cindy; Obermann Wolfgang M J; Toft David
Role of the cochaperone Tpr2 in Hsp90 chaperoning.
Biochemistry 2008;47(31):8203-13.
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2008: Chadli Ahmed; Felts Sara J; Toft David O
GCUNC45 is the first Hsp90 co-chaperone to show alpha/beta isoform specificity.
The Journal of biological chemistry 2008;283(15):9509-12.
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2008: Chadli Ahmed; Bruinsma Elizabeth S; Stensgard Bridget; Toft David
Analysis of Hsp90 cochaperone interactions reveals a novel mechanism for TPR protein recognition.
Biochemistry 2008;47(9):2850-7.
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2007: Scroggins Bradley T; Robzyk Kenneth; Wang Dongxia; Marcu Monica G; Tsutsumi Shinji; Beebe Kristin; Cotter Robert J; Felts Sara; Toft David; Karnitz Larry; Rosen Neal; Neckers Len
An acetylation site in the middle domain of Hsp90 regulates chaperone function.
Molecular cell 2007;25(1):151-9.
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2007: Felts Sara J; Karnitz Larry M; Toft David O
Functioning of the Hsp90 machine in chaperoning checkpoint kinase I (Chk1) and the progesterone receptor (PR).
Cell stress & chaperones 2007;12(4):353-63.
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2006: McCollum Andrea K; Teneyck Cynthia J; Sauer Brian M; Toft David O; Erlichman Charles
Up-regulation of heat shock protein 27 induces resistance to 17-allylamino-demethoxygeldanamycin through a glutathione-mediated mechanism.
Cancer research 2006;66(22):10967-75.
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2006: Nowakowski Grzegorz S; McCollum Andrea K; Ames Matthew M; Mandrekar Sumithra J; Reid Joel M; Adjei Alex A; Toft David O; Safgren Stephanie L; Erlichman Charles
A phase I trial of twice-weekly 17-allylamino-demethoxy-geldanamycin in patients with advanced cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(20 Pt 1):6087-93.
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2006: Cintron Nela S; Toft David
Defining the requirements for Hsp40 and Hsp70 in the Hsp90 chaperone pathway.
The Journal of biological chemistry 2006;281(36):26235-44.
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2006: Chadli Ahmed; Graham J Dinny; Abel M Greg; Jackson Twila A; Gordon David F; Wood William M; Felts Sara J; Horwitz Kathryn B; Toft David
GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway.
Molecular and cellular biology 2006;26(5):1722-30.
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2006: Arlander Sonnet J H; Felts Sara J; Wagner Jill M; Stensgard Bridget; Toft David O; Karnitz Larry M
Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones.
The Journal of biological chemistry 2006;281(5):2989-98.
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2005: Goetz Matthew P; Toft David; Reid Joel; Ames Matthew; Stensgard Bridget; Safgren Stephanie; Adjei Araba A; Sloan Jeff; Atherton Pamela; Vasile Vlad; Salazaar Sandra; Adjei Alex; Croghan Gary; Erlichman Charles
Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(6):1078-87.
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2004: Elbi Cem; Walker Dawn A; Lewis Marcia; Romero Guillermo; Sullivan William P; Toft David O; Hager Gordon L; DeFranco Donald B
A novel in situ assay for the identification and characterization of soluble nuclear mobility factors.
Science's STKE : signal transduction knowledge environment 2004;2004(238):pl10.
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2004: Elbi Cem; Walker Dawn A; Romero Guillermo; Sullivan William P; Toft David O; Hager Gordon L; DeFranco Donald B
Molecular chaperones function as steroid receptor nuclear mobility factors.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):2876-81.
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2004: Carrello Amerigo; Allan Rudi K; Morgan Sarah L; Owen Barbara A L; Mok Danny; Ward Bryan K; Minchin Rodney F; Toft David O; Ratajczak Thomas
Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70.
Cell stress & chaperones 2004;9(2):167-81.
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2003: Arlander Sonnet J H; Eapen Alex K; Vroman Benjamin T; McDonald Robert J; Toft David O; Karnitz Larry M
Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress.
The Journal of biological chemistry 2003;278(52):52572-7.
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2003: Wang Liewei; Sullivan William; Toft David; Weinshilboum Richard
Thiopurine S-methyltransferase pharmacogenetics: chaperone protein association and allozyme degradation.
Pharmacogenetics 2003;13(9):555-64.
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2003: Goetz M P; Toft D O; Ames M M; Erlichman C
The Hsp90 chaperone complex as a novel target for cancer therapy.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2003;14(8):1169-76.
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2003: Felts Sara J; Toft David O
p23, a simple protein with complex activities.
Cell stress & chaperones 2003;8(2):108-13.
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2002: Sullivan William P; Owen Barbara A L; Toft David O
The influence of ATP and p23 on the conformation of hsp90.
The Journal of biological chemistry 2002;277(48):45942-8.
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2002: Hernández M Patricia; Sullivan William P; Toft David O
The assembly and intermolecular properties of the hsp70-Hop-hsp90 molecular chaperone complex.
The Journal of biological chemistry 2002;277(41):38294-304.
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2002: Shastry S; Toft D O; Joyner M J
HSP70 and HSP90 expression in leucocytes after exercise in moderately trained humans.
Acta physiologica Scandinavica 2002;175(2):139-46.
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2002: Hernández M Patricia; Chadli Ahmed; Toft David O
HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor.
The Journal of biological chemistry 2002;277(14):11873-81.
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2002: Owen Barbara A L; Sullivan William P; Felts Sara J; Toft David O
Regulation of heat shock protein 90 ATPase activity by sequences in the carboxyl terminus.
The Journal of biological chemistry 2002;277(9):7086-91.
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2000: Chadli A; Bouhouche I; Sullivan W; Stensgard B; McMahon N; Catelli M G; Toft D O
Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(23):12524-9.
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2000: Johnson B D; Chadli A; Felts S J; Bouhouche I; Catelli M G; Toft D O
Hsp90 chaperone activity requires the full-length protein and interaction among its multiple domains.
The Journal of biological chemistry 2000;275(42):32499-507.
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2000: Weaver A J; Sullivan W P; Felts S J; Owen B A; Toft D O
Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone.
The Journal of biological chemistry 2000;275(30):23045-52.
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2000: Freeman B C; Felts S J; Toft D O; Yamamoto K R
The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies.
Genes & development 2000;14(4):422-34.
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2000: Felts S J; Owen B A; Nguyen P; Trepel J; Donner D B; Toft D O
The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties.
The Journal of biological chemistry 2000;275(5):3305-12.
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1999: Schulte T W; Akinaga S; Murakata T; Agatsuma T; Sugimoto S; Nakano H; Lee Y S; Simen B B; Argon Y; Felts S; Toft D O; Neckers L M; Sharma S V
Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones.
Molecular endocrinology (Baltimore, Md.) 1999;13(9):1435-48.
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1999: Grenert J P; Johnson B D; Toft D O
The importance of ATP binding and hydrolysis by hsp90 in formation and function of protein heterocomplexes.
The Journal of biological chemistry 1999;274(25):17525-33.
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1998: Kosano H; Stensgard B; Charlesworth M C; McMahon N; Toft D
The assembly of progesterone receptor-hsp90 complexes using purified proteins.
The Journal of biological chemistry 1998;273(49):32973-9.
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1998: Bartha B B; Ajtai K; Toft D O; Burghardt T P
ATP sensitive tryptophans of hsp90.
Biophysical chemistry 1998;72(3):313-21.
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1998: Chen S; Sullivan W P; Toft D O; Smith D F
Differential interactions of p23 and the TPR-containing proteins Hop, Cyp40, FKBP52 and FKBP51 with Hsp90 mutants.
Cell stress & chaperones 1998;3(2):118-29.
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1998: Schulte T W; Akinaga S; Soga S; Sullivan W; Stensgard B; Toft D; Neckers L M
Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin.
Cell stress & chaperones 1998;3(2):100-8.
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1998: Johnson B D; Schumacher R J; Ross E D; Toft D O
Hop modulates Hsp70/Hsp90 interactions in protein folding.
The Journal of biological chemistry 1998;273(6):3679-86.
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1997: Grenert J P; Sullivan W P; Fadden P; Haystead T A; Clark J; Mimnaugh E; Krutzsch H; Ochel H J; Schulte T W; Sausville E; Neckers L M; Toft D O
The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation.
The Journal of biological chemistry 1997;272(38):23843-50.
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1997: Sullivan W; Stensgard B; Caucutt G; Bartha B; McMahon N; Alnemri E S; Litwack G; Toft D
Nucleotides and two functional states of hsp90.
The Journal of biological chemistry 1997;272(12):8007-12.
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1996: Freeman B C; Toft D O; Morimoto R I
Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23.
Science (New York, N.Y.) 1996;274(5293):1718-20.
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1996: Schumacher R J; Hansen W J; Freeman B C; Alnemri E; Litwack G; Toft D O
Cooperative action of Hsp70, Hsp90, and DnaJ proteins in protein renaturation.
Biochemistry 1996;35(47):14889-98.
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1996: Johnson J; Corbisier R; Stensgard B; Toft D
The involvement of p23, hsp90, and immunophilins in the assembly of progesterone receptor complexes.
The Journal of steroid biochemistry and molecular biology 1996;56(1-6 Spec No):31-7.
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1995: Milad M; Sullivan W; Diehl E; Altmann M; Nordeen S; Edwards D P; Toft D O
Interaction of the progesterone receptor with binding proteins for FK506 and cyclosporin A.
Molecular endocrinology (Baltimore, Md.) 1995;9(7):838-47.
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1995: Johnson J L; Toft D O
Binding of p23 and hsp90 during assembly with the progesterone receptor.
Molecular endocrinology (Baltimore, Md.) 1995;9(6):670-8.
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1994: Johnson J L; Toft D O
A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23.
The Journal of biological chemistry 1994;269(40):24989-93.
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1994: Schumacher R J; Hurst R; Sullivan W P; McMahon N J; Toft D O; Matts R L
ATP-dependent chaperoning activity of reticulocyte lysate.
The Journal of biological chemistry 1994;269(13):9493-9.
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1994: Johnson J L; Beito T G; Krco C J; Toft D O
Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes.
Molecular and cellular biology 1994;14(3):1956-63.
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1993: Sullivan W P; Toft D O
Mutational analysis of hsp90 binding to the progesterone receptor.
The Journal of biological chemistry 1993;268(27):20373-9.
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1993: Tai P K; Chang H; Albers M W; Schreiber S L; Toft D O; Faber L E
P59 (FK506 binding protein 59) interaction with heat shock proteins is highly conserved and may involve proteins other than steroid receptors.
Biochemistry 1993;32(34):8842-7.
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1993: Smith D F; Sullivan W P; Marion T N; Zaitsu K; Madden B; McCormick D J; Toft D O
Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70.
Molecular and cellular biology 1993;13(2):869-76.
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1993: Smith D F; Toft D O
Steroid receptors and their associated proteins.
Molecular endocrinology (Baltimore, Md.) 1993;7(1):4-11.
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1992: Smith D F; Toft D O
Composition, assembly and activation of the avian progesterone receptor.
The Journal of steroid biochemistry and molecular biology 1992;41(3-8):201-7.
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1992: Smith D F; Stensgard B A; Welch W J; Toft D O
Assembly of progesterone receptor with heat shock proteins and receptor activation are ATP mediated events.
The Journal of biological chemistry 1992;267(2):1350-6.
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1991: Schowalter D B; Sullivan W P; Maihle N J; Dobson A D; Conneely O M; O'Malley B W; Toft D O
Characterization of progesterone receptor binding to the 90- and 70-kDa heat shock proteins.
The Journal of biological chemistry 1991;266(31):21165-73.
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1990: Smith D F; Schowalter D B; Kost S L; Toft D O
Reconstitution of progesterone receptor with heat shock proteins.
Molecular endocrinology (Baltimore, Md.) 1990;4(11):1704-11.
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1990: Smith D F; Faber L E; Toft D O
Purification of unactivated progesterone receptor and identification of novel receptor-associated proteins.
The Journal of biological chemistry 1990;265(7):3996-4003.
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1990: Schowalter D B; Toft D O; Sommer S S
A method of sequencing without subcloning and its application to the identification of a novel ORF with a sequence suggestive of a transcriptional regulator in the water mold Achlya ambisexualis.
Genomics 1990;6(1):23-32.
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1989: Kost S L; Smith D F; Sullivan W P; Welch W J; Toft D O
Binding of heat shock proteins to the avian progesterone receptor.
Molecular and cellular biology 1989;9(9):3829-38.
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1988: Sullivan W P; Madden B J; McCormick D J; Toft D O
Hormone-dependent phosphorylation of the avian progesterone receptor.
The Journal of biological chemistry 1988;263(29):14717-23.
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1988: Smith D F; Lubahn D B; McCormick D J; Wilson E M; Toft D O
The production of antibodies against the conserved cysteine region of steroid receptors and their use in characterizing the avian progesterone receptor.
Endocrinology 1988;122(6):2816-25.
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1988: Schneider W; Toft D O; Sullivan W P; Shyamala G
Interaction of murine progesterone receptors with specific monoclonal antibodies to the avian progesterone receptor.
Journal of steroid biochemistry 1988;29(3):297-306.
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1988: Sullivan W P; Smith D F; Beito T G; Krco C J; Toft D O
Hormone-dependent processing of the avian progesterone receptor.
Journal of cellular biochemistry 1988;36(2):103-19.
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1988: Smith D F; McCormick D J; Toft D O
Studies with antibodies against the conserved cysteine region of progesterone receptor.
Journal of steroid biochemistry 1988;30(1-6):1-7.
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1987: Conneely O M; Maxwell B L; Toft D O; Schrader W T; O'Malley B W
The A and B forms of the chicken progesterone receptor arise by alternate initiation of translation of a unique mRNA.
Biochemical and biophysical research communications 1987;149(2):493-501.
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1987: Carson M A; Tsai M J; Conneely O M; Maxwell B L; Clark J H; Dobson A D; Elbrecht A; Toft D O; Schrader W T; O'Malley B W
Structure-function properties of the chicken progesterone receptor A synthesized from complementary deoxyribonucleic acid.
Molecular endocrinology (Baltimore, Md.) 1987;1(11):791-801.
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1987: Wei L L; Sheridan P L; Krett N L; Francis M D; Toft D O; Edwards D P; Horwitz K B
Immunologic analysis of human breast cancer progesterone receptors. 2. Structure, phosphorylation, and processing.
Biochemistry 1987;26(19):6262-72.
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1987: Estes P A; Suba E J; Lawler-Heavner J; Elashry-Stowers D; Wei L L; Toft D O; Sullivan W P; Horwitz K B; Edwards D P
Immunologic analysis of human breast cancer progesterone receptors. 1. Immunoaffinity purification of transformed receptors and production of monoclonal antibodies.
Biochemistry 1987;26(19):6250-62.
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1987: Conneely O M; Dobson A D; Tsai M J; Beattie W G; Toft D O; Huckaby C S; Zarucki T; Schrader W T; O'Malley B W
Sequence and expression of a functional chicken progesterone receptor.
Molecular endocrinology (Baltimore, Md.) 1987;1(8):517-25.
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1987: Dougherty J J; Rabideau D A; Iannotti A M; Sullivan W P; Toft D O
Identification of the 90 kDa substrate of rat liver type II casein kinase with the heat shock protein which binds steroid receptors.
Biochimica et biophysica acta 1987;927(1):74-80.
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1986: Sullivan W P; Beito T G; Proper J; Krco C J; Toft D O
Preparation of monoclonal antibodies to the avian progesterone receptor.
Endocrinology 1986;119(4):1549-57.
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1986: Conneely O M; Sullivan W P; Toft D O; Birnbaumer M; Cook R G; Maxwell B L; Zarucki-Schulz T; Greene G L; Schrader W T; O'Malley B W
Molecular cloning of the chicken progesterone receptor.
Science (New York, N.Y.) 1986;233(4765):767-70.
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1985: Riehl R M; Sullivan W P; Vroman B T; Bauer V J; Pearson G R; Toft D O
Immunological evidence that the nonhormone binding component of avian steroid receptors exists in a wide range of tissues and species.
Biochemistry 1985;24(23):6586-91.
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1985: Schuh S; Yonemoto W; Brugge J; Bauer V J; Riehl R M; Sullivan W P; Toft D O
A 90,000-dalton binding protein common to both steroid receptors and the Rous sarcoma virus transforming protein, pp60v-src.
The Journal of biological chemistry 1985;260(26):14292-6.
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1985: Riehl R M; Toft D O
Effect of culture medium composition on pheromone receptor levels in Achlya ambisexualis.
Journal of steroid biochemistry 1985;23(4):483-9.
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1985: Sullivan W P; Vroman B T; Bauer V J; Puri R K; Riehl R M; Pearson G R; Toft D O
Isolation of steroid receptor binding protein from chicken oviduct and production of monoclonal antibodies.
Biochemistry 1985;24(15):4214-22.
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1984: Riehl R M; Toft D O
Analysis of the steroid receptor of Achlya ambisexualis.
The Journal of biological chemistry 1984;259(24):15324-30.
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1984: Riehl R M; Toft D O; Meyer M D; Carlson G L; McMorris T C
Detection of a pheromone-binding protein in the aquatic fungus Achlya ambisexualis.
Experimental cell research 1984;153(2):544-9.
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1984: Dougherty J J; Puri R K; Toft D O
Polypeptide components of two 8 S forms of chicken oviduct progesterone receptor.
The Journal of biological chemistry 1984;259(12):8004-9.
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1984: Puri R K; Dougherty J J; Toft D O
The avian progesterone receptor: isolation and characterization of phosphorylated forms.
Journal of steroid biochemistry 1984;20(1):23-9.
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1983: Pellikka P A; Sullivan W P; Coulam C B; Toft D O
Comparison of estrogen receptors in human premenopausal and postmenopausal uteri using isoelectric focusing.
Obstetrics and gynecology 1983;62(4):430-4.
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1982: Dougherty J J; Puri R K; Toft D O
Phosphorylation in vivo of chicken oviduct progesterone receptor.
The Journal of biological chemistry 1982;257(23):14226-30.
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1982: Puri R K; Grandics P; Dougherty J J; Toft D O
Purification of "nontransformed" avian progesterone receptor and preliminary characterization.
The Journal of biological chemistry 1982;257(18):10831-7.
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1982: Dougherty J J; Toft D O
Characterization of two 8 S forms of chick oviduct progesterone receptor.
The Journal of biological chemistry 1982;257(6):3113-9.
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