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Junya Toguchida

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Kazuo Hayakawa; Makoto Ikeya; Tomohisa Kato; Takanobu Otsuka; Shingo Sato; Naoko Takahara; Sakura Tamaki; Makoto Fukuta; Knut Woltjen; Junya Toguchida
Identification of target genes of synovial sarcoma-associated fusion oncoprotein using human pluripotent stem cells.
Kazunari Yamada; Hitomi Aoki; Akira Hara; Yukiko Kobayashi; Takahiro Kunisada; Hiroshi Moritake; Takatoshi Ohno; Katsunori Semi; Katsuji Shimizu; Shunichi Shiozawa; Junya Toguchida; Akira Watanabe; Yasuhiro Yamada
EWS/ATF1 expression induces sarcomas from neural crest-derived cells in mice.
Akira Nasu; Kenji Osafune; Shingo Sato; Akira Watanabe; Takuya Yamamoto; Naoki Amano; Tomoki Aoyama; Kazuo Hayakawa; Makoto Ikeya; Yonghui Jin; Tomohisa Kato; Yoshihisa Matsumoto; Takashi Nakamura; Junya Toguchida
Genetically matched human iPS cells reveal that propensity for cartilage and bone differentiation differs with clones, not cell type of origin.

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2013: Kazuo Hayakawa; Makoto Ikeya; Tomohisa Kato; Takanobu Otsuka; Shingo Sato; Naoko Takahara; Sakura Tamaki; Makoto Fukuta; Knut Woltjen; Junya Toguchida
Identification of target genes of synovial sarcoma-associated fusion oncoprotein using human pluripotent stem cells.
Biochemical and biophysical research communications 2013;432(4):713-9.
2013: Kazunari Yamada; Hitomi Aoki; Akira Hara; Yukiko Kobayashi; Takahiro Kunisada; Hiroshi Moritake; Takatoshi Ohno; Katsunori Semi; Katsuji Shimizu; Shunichi Shiozawa; Junya Toguchida; Akira Watanabe; Yasuhiro Yamada
EWS/ATF1 expression induces sarcomas from neural crest-derived cells in mice.
The Journal of clinical investigation 2013;123(2):600-10.
2013: Akira Nasu; Kenji Osafune; Shingo Sato; Akira Watanabe; Takuya Yamamoto; Naoki Amano; Tomoki Aoyama; Kazuo Hayakawa; Makoto Ikeya; Yonghui Jin; Tomohisa Kato; Yoshihisa Matsumoto; Takashi Nakamura; Junya Toguchida
Genetically matched human iPS cells reveal that propensity for cartilage and bone differentiation differs with clones, not cell type of origin.
PloS one 2013;8(1):e53771.
2013: Yoichiro Kajita; Toyomasa Katagiri; Tomohisa Kato; Satoshi Nagayama; Eijiro Nakamura; Yusuke Nakamura; Hiroyuki Nishiyama; Osamu Ogawa; Ryo Takahashi; Sakura Tamaki; Tomoki Aoyama; Moritoshi Furu; Junya Toguchida
The transcription factor Sp3 regulates the expression of a metastasis-related marker of sarcoma, actin filament-associated protein 1-like 1 (AFAP1L1).
PloS one 2013;8(1):e49709.
2012: Masatoshi Kajiwara; Keisuke Okita; Ryosuke Takahashi; Naoya Takayama; Junya Toguchida; Shinji Uemoto; Takashi Aoi; Hiroshi Endo; Koji Eto; Haruhisa Inoue; Shinya Yamanaka
Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(31):12538-43.
2012: Yusaku Masago; Hiroaki Nakamura; Akira Nasu; Junya Toguchida; Katsumasa Fujita; Akihiro Hosoya; Shogo Kawano; Kunito Kawasaki; Gen Kondoh; Kazuhiro Nagata
The molecular chaperone Hsp47 is essential for cartilage and endochondral bone formation.
Journal of cell science 2012;125(Pt 5):1118-28.
2011: Junya Toguchida; Tomoki Aoyama; Koji Goto; Ryosuke Kakinoki; Yasunari Kasai
[Cell therapy for aseptic necrosis of femoral head].
Nihon rinsho. Japanese journal of clinical medicine 2011;69(12):2225-30.
2011: Moritoshi Furu; Masaya Ikegawa; S Imoto; Tatsuya Ishibe; Y Kajita; Toyomasa Katagiri; Satoshi Nagayama; Y Nakamura; Tetsuya Nakamura; Y Nakashima; Tomitaka Nakayama; Koichi Nishijo; Yasuko Shima; Rei Takahashi; Tomoki Aoyama; D Uejima; Junya Toguchida
Identification of AFAP1L1 as a prognostic marker for spindle cell sarcomas.
Oncogene 2011;30(38):4015-25.
2011: Daisuke Uejima; Koichi Nishijo; Yoichiro Kajita; Tatsuya Ishibe; Tomoki Aoyama; Susumu Kageyama; Hideaki Iwaki; Takashi Nakamura; Hirokazu Iida; Tatsuhiro Yoshiki; Junya Toguchida
Involvement of cancer biomarker C7orf24 in the growth of human osteosarcoma.
Anticancer research 2011;31(4):1297-305.
2011: Hiroto Mitsui; Takashi Nakamura; Akio Nishiura; Takanobu Otsuka; Hikaru Sugihara; Tomoki Aoyama; Shinsei Fujimura; Moritoshi Furu; Kinya Ito; Yonghui Jin; Toshiya Kanaji; Takayuki Maruyama; Junya Toguchida
Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability.
Arthritis research & therapy 2011;13(5):R146.
2011: Tatsuya Nishigaki; Kei Takada; Yuji Teramura; Junya Toguchida; Akira Nasu; Hiroo Iwata
Highly efficient cryopreservation of human induced pluripotent stem cells using a dimethyl sulfoxide-free solution.
The International journal of developmental biology 2011;55(3):305-11.
2010: Robert Nakayama; Sachiyo Mitani; Takeshi Nakagawa; Tadashi Hasegawa; Akira Kawai; Hideo Morioka; Hiroo Yabe; Yoshiaki Toyama; Akira Ogose; Junya Toguchida; Tomitaka Nakayama; Teruhiko Yoshida; Hitoshi Ichikawa
Gene expression profiling of synovial sarcoma: distinct signature of poorly differentiated type.
The American journal of surgical pathology 2010;34(11):1599-607.
2010: Tomoki Aoyama; Takeshi Okamoto; Kenichi Fukiage; Seiji Otsuka; Moritoshi Furu; Kinya Ito; Yonghui Jin; Michiko Ueda; Satoshi Nagayama; Tomitaka Nakayama; Takashi Nakamura; Junya Toguchida
Histone modifiers, YY1 and p300, regulate the expression of cartilage-specific gene, chondromodulin-I, in mesenchymal stem cells.
The Journal of biological chemistry 2010;285(39):29842-50.
2010: Shunsuke Fujibayashi; Masashi Neo; Mitsuru Takemoto; Masato Ota; Tomitaka Nakayama; Junya Toguchida; Takashi Nakamura
Computer-assisted spinal osteotomy: a technical note and report of four cases.
Spine 2010;35(18):E895-903.
2010: Kinya Ito; Tomoki Aoyama; Kenichi Fukiage; Seiji Otsuka; Moritoshi Furu; Yonghui Jin; Akira Nasu; Michiko Ueda; Yasunari Kasai; Eishi Ashihara; Shinya Kimura; Taira Maekawa; Akira Kobayashi; Shinya Yoshida; Hideo Niwa; Takanobu Otsuka; Takashi Nakamura; Junya Toguchida
A novel method to isolate mesenchymal stem cells from bone marrow in a closed system using a device made by nonwoven fabric.
Tissue engineering. Part C, Methods 2010;16(1):81-91.
2010: Yonghui Jin; Tomohisa Kato; Moritoshi Furu; Akira Nasu; Yoichiro Kajita; Hiroto Mitsui; Michiko Ueda; Tomoki Aoyama; Tomitaka Nakayama; Takashi Nakamura; Junya Toguchida
Mesenchymal stem cells cultured under hypoxia escape from senescence via down-regulation of p16 and extracellular signal regulated kinase.
Biochemical and biophysical research communications 2010;391(3):1471-6.
2010: Yonghui Jin; Yasuko Shima; Moritoshi Furu; Tomoki Aoyama; Takeharu Nakamata; Tomitaka Nakayama; Takashi Nakamura; Junya Toguchida
Absence of oncogenic mutations of RAS family genes in soft tissue sarcomas of 100 Japanese patients.
Anticancer research 2010;30(1):245-51.
2009: Fengshi Chen; Ryo Miyahara; Toru Bando; Kenichi Okubo; Kenichiro Watanabe; Tomitaka Nakayama; Junya Toguchida; Hiroshi Date
Repeat resection of pulmonary metastasis is beneficial for patients with osteosarcoma of the extremities.
Interactive cardiovascular and thoracic surgery 2009;9(4):649-53.
2009: Junya Toguchida; Tomitaka Nakayama
Molecular genetics of sarcomas: applications to diagnoses and therapy.
Cancer science 2009;100(9):1573-80.
2009: Kae Okoshi; Satoshi Nagayama; Moritoshi Furu; Yukiko Mori; Akihiko Yoshizawa; Junya Toguchida; Yoshiharu Sakai
A case report of pathologically complete response of a huge rectal cancer after systemic chemotherapy with mFOLFOX6.
Japanese journal of clinical oncology 2009;39(8):528-33.
2009: Hiromasa Morikawa; Toru Tanaka; Masatsugu Hamaji; Yoichiro Ueno; Shigeo Yasuda; Tatsuo Kato; Yoshiki Kohno; Junya Toguchida
A case of primary synovial sarcoma of the thorax with a variant SYT-SSX1 fusion transcript.
The Annals of thoracic surgery 2009;88(1):297-300.
2009: Hiromichi Katakura; Tatsuo Fukuse; I Shiraishi; E Hayatsu; Koichi Nishijo; Junya Toguchida; Yasuaki Nakashima; Hiromi Wada
Mediastinal synovial sarcoma.
The Thoracic and cardiovascular surgeon 2009;57(3):183-5.
2009: Seiji Otsuka; Tomoki Aoyama; Moritoshi Furu; Koreaki Ito; Y Jin; A Nasu; Kenichi Fukiage; Yoshiki Kohno; Takayuki Maruyama; T Kanaji; A Nishiura; H Sugihara; S Fujimura; T Otsuka; Tetsuya Nakamura; Junya Toguchida
PGE2 signal via EP2 receptors evoked by a selective agonist enhances regeneration of injured articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2009;17(4):529-38.
2009: Satoshi Nagayama; Eiji Yamada; Yoshiki Kohno; Tomoki Aoyama; Chikako Fukukawa; Hajime Kubo; Go Watanabe; Toyomasa Katagiri; Y Nakamura; Yoshiharu Sakai; Junya Toguchida
Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors.
Cancer science 2009;100(3):405-12.
2009: Hiroshi Matsubara; Motonobu Watanabe; Tsuyoshi Imai; Yoshiki Yui; Yasuhiro Mizushima; Yoshimi Hiraumi; Yuri Kamitsuji; Ken-Ichiro Watanabe; Koichi Nishijo; Junya Toguchida; Tatsutoshi Nakahata; Souichi Adachi
Involvement of extracellular signal-regulated kinase activation in human osteosarcoma cell resistance to the histone deacetylase inhibitor FK228 [(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone].
The Journal of pharmacology and experimental therapeutics 2009;328(3):839-48.
2009: C Fukukawa; Satoshi Nagayama; Tatsuhiko Tsunoda; Junya Toguchida; Yusuke Nakamura; Toyomasa Katagiri
Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma.
Oncogene 2009;28(8):1110-20.
2009: Motonobu Watanabe; Souichi Adachi; Hiroshi Matsubara; Tsuyoshi Imai; Yoshiki Yui; Yasuhiro Mizushima; Yoshimi Hiraumi; Ken-ichiro Watanabe; Yuri Kamitsuji; Shinya Toyokuni; Hajime Hosoi; Toru Sugimoto; Junya Toguchida; Tatsutoshi Nakahata
Induction of autophagy in malignant rhabdoid tumor cells by the histone deacetylase inhibitor FK228 through AIF translocation.
International journal of cancer. Journal international du cancer 2009;124(1):55-67.
2008: Fengshi Chen; Ryo Miyahara; Toru Bando; Kenichi Okubo; Kenichiro Watanabe; Tomitaka Nakayama; Junya Toguchida; Hiroshi Date
Prognostic factors of pulmonary metastasectomy for osteosarcomas of the extremities.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2008;34(6):1235-9.
2008: Masaya Ikegawa; Hua Han; Akihiko Okamoto; Ryosuke Matsui; Masami Tanaka; Natsue Omi; Mahito Miyamae; Junya Toguchida; Kei Tashiro
Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice.
Developmental dynamics : an official publication of the American Association of Anatomists 2008;237(9):2506-17.
2008: Tatsuya Ishibe; Tomitaka Nakayama; Tomoki Aoyama; Takashi Nakamura; Junya Toguchida
Neuronal differentiation of synovial sarcoma and its therapeutic application.
Clinical orthopaedics and related research 2008;466(9):2147-55.
2008: Takafumi Ueda; Norifumi Naka; Nobuhito Araki; Takeshi Ishii; Hiroyuki Tsuchiya; Hideki Yoshikawa; Kazuo Mochizuki; Tadao Tsuboyama; Junya Toguchida; Toshifumi Ozaki; Hiroaki Murata; Ikuo Kudawara; Kazuhiro Tanaka; Yukihide Iwamoto; Yasuo Yazawa; Kazuyoshi Kushida; Takanobu Otsuka; Keiji Sato
Validation of radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas: Japanese Orthopaedic Association Committee on Musculoskeletal Tumors Cooperative Study.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2008;13(4):304-12.
2008: Satoshi Hasegawa; Tomoki Aoyama; Ryosuke Kakinoki; Junya Toguchida; Takashi Nakamura
Bilateral phlegmasia dolens associated with Trousseau's syndrome: a case report.
Archives of physical medicine and rehabilitation 2008;89(6):1187-90.
2008: Chikako Fukukawa; Hirofumi Hanaoka; Satoshi Nagayama; Tatsuhiko Tsunoda; Junya Toguchida; Keigo Endo; Yusuke Nakamura; Toyomasa Katagiri
Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against FZD10.
Cancer science 2008;99(2):432-40.
2008: Satoshi Takenaka; Takafumi Ueda; Norifumi Naka; Nobuhito Araki; Nobuyuki Hashimoto; Akira Myoui; Toshifumi Ozaki; Tomitaka Nakayama; Junya Toguchida; Kazuhiro Tanaka; Yukihide Iwamoto; Akihiko Matsumine; Atsumasa Uchida; Makoto Ieguchi; Mitsunori Kaya; Takuro Wada; Ichiro Baba; Ikuo Kudawara; Yasuaki Aoki; Hideki Yoshikawa
Prognostic implication of SYT-SSX fusion type in synovial sarcoma: a multi-institutional retrospective analysis in Japan.
Oncology reports 2008;19(2):467-76.
2008: Kenichi Fukiage; Tomoki Aoyama; Kotaro R Shibata; Seiji Otsuka; Moritoshi Furu; Yoshiki Kohno; Kinya Ito; Yonghui Jin; Satoshi Fujita; Shunsuke Fujibayashi; Masashi Neo; Tomitaka Nakayama; Takashi Nakamura; Junya Toguchida
Expression of vascular cell adhesion molecule-1 indicates the differentiation potential of human bone marrow stromal cells.
Biochemical and biophysical research communications 2008;365(3):406-12.
2008: Tomoki Aoyama; Takeshi Okamoto; Yoshiki Kohno; Kenichi Fukiage; Seiji Otsuka; Moritoshi Furu; Kinya Ito; Yonghui Jin; Satoshi Nagayama; Tomitaka Nakayama; Takashi Nakamura; Junya Toguchida
Cell-specific epigenetic regulation of ChM-I gene expression: crosstalk between DNA methylation and histone acetylation.
Biochemical and biophysical research communications 2008;365(1):124-30.
2008: Satoshi Fujita; Junya Toguchida; Yutaka Morita; Hiroo Iwata
Clonal analysis of hematopoiesis-supporting activity of human mesenchymal stem cells in association with Jagged1 expression and osteogenic potential.
Cell transplantation 2008;17(10-11):1169-79.
2008: Tomitaka Nakayama; Tadao Tsuboyama; Junya Toguchida; Taisuke Hosaka; Takashi Nakamura
Natural course of desmoid-type fibromatosis.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2008;13(1):51-5.
2007: Shinya Osone; Hajime Hosoi; Kazushi Tanaka; Kunihiko Tsuchiya; Tomoko Iehara; akira morimoto; Tetsuo Hashida; Masuo Yamashita; Kenji Kawabata; Koichi Nishijo; Junya Toguchida; Jun-Ichi Hata; Tohru Sugimoto
A case of a ewing sarcoma family tumor in the urinary bladder after treatment for acute lymphoblastic leukemia.
Journal of pediatric hematology/oncology 2007;29(12):841-4.
2007: Nanae Fujimoto; Satoshi Fujita; Takashi Tsuji; Junya Toguchida; Kenji Ida; Hiroshi Suginami; Hiroo Iwata
Microencapsulated feeder cells as a source of soluble factors for expansion of CD34(+) hematopoietic stem cells.
Biomaterials 2007;28(32):4795-805.
2007: Takashi Matsusaki; Keiichi Kawanabe; Kentaro Ise; Tomitaka Nakayama; Junya Toguchida; Takashi Nakamura
Gene expression profile of macrophage-like U937 cells in response to polyethylene particles: a novel cell-particle culture system.
The Journal of arthroplasty 2007;22(7):960-5.
2007: Kotaro R Shibata; Tomoki Aoyama; Yasuko Shima; Kenichi Fukiage; Seiji Otsuka; Moritoshi Furu; Yoshiki Kohno; Kinya Ito; Shunsuke Fujibayashi; Masashi Neo; Tomitaka Nakayama; Takashi Nakamura; Junya Toguchida
Expression of the p16INK4A gene is associated closely with senescence of human mesenchymal stem cells and is potentially silenced by DNA methylation during in vitro expansion.
Stem cells (Dayton, Ohio) 2007;25(9):2371-82.
2007: Hideki Sato; Hirofumi Suemori; Junya Toguchida; Hiroo Iwata
Recombinant matrix protein for maintenance of undifferentiated primate embryonic stem cells.
Tissue engineering 2007;13(7):1539-47.
2007: Yasuko Shima; Takeshi Okamoto; Tomoki Aoyama; Ko Yasura; Tatsuya Ishibe; Koichi Nishijo; Kotaro R Shibata; Yoshiki Kohno; Kenichi Fukiage; Seiji Otsuka; Daisuke Uejima; Tomitaka Nakayama; Takashi Nakamura; Tohru Kiyono; Junya Toguchida
In vitro transformation of mesenchymal stem cells by oncogenic H-rasVal12.
Biochemical and biophysical research communications 2007;353(1):60-6.
2007: Susumu Kageyama; Hideaki Iwaki; Hirokazu Inoue; Takahiro Isono; Takeshi Yuasa; Masaki Nogawa; Taira Maekawa; Masamichi Ueda; Yoichiro Kajita; Osamu Ogawa; Junya Toguchida; Tatsuhiro Yoshiki
A novel tumor-related protein, C7orf24, identified by proteome differential display of bladder urothelial carcinoma.
Proteomics. Clinical applications 2007;1(2):192-9.
2006: Yoshiki Kohno; Takeshi Okamoto; Tatsuya Ishibe; Satoshi Nagayama; Yasuko Shima; Koichi Nishijo; Kotaro R Shibata; Kenichi Fukiage; Seiji Otsuka; Daisuke Uejima; Nobuhito Araki; Norifumi Naka; Yasuaki Nakashima; Tomoki Aoyama; Tomitaka Nakayama; Takashi Nakamura; Junya Toguchida
Expression of claudin7 is tightly associated with epithelial structures in synovial sarcomas and regulated by an Ets family transcription factor, ELF3.
The Journal of biological chemistry 2006;281(50):38941-50.
2006: Seiji Otsuka; Koichi Nishijo; Tomitaka Nakayama; Tomoki Aoyama; Tatsuya Ishibe; Kotaro R Shibata; Yasuko Shima; Takashi Nakamura; Takanobu Otsuka; Junya Toguchida
A variant of the SYT-SSX2 fusion gene in a case of synovial sarcoma.
Cancer genetics and cytogenetics 2006;167(1):82-8.
2006: Takashi Matsusaki; Tomoki Aoyama; Koichi Nishijo; Takeshi Okamoto; Tomitaka Nakayama; Tetsuya Nakamura; Junya Toguchida
Expression of the cadherin-11 gene is a discriminative factor between articular and growth plate chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2006;14(4):353-66.
2006: Ryosuke Ikeguchi; Ryosuke Kakinoki; Tomoki Aoyama; Kotaro Roberts Shibata; Seiji Otsuka; Kenichi Fukiage; Koichi Nishijo; Tatsuya Ishibe; Yasuko Shima; Bungo Otsuki; Takashi Azuma; Sadami Tsutsumi; Tomitaka Nakayama; Takanobu Otsuka; Takashi Nakamura; Junya Toguchida
Regeneration of osteonecrosis of canine scapho-lunate using bone marrow stromal cells: possible therapeutic approach for Kienböck disease.
Cell transplantation 2006;15(5):411-22.
2005: Xianying Ren; Motonobu Katoh; Hidetoshi Hoshiya; Akihiro Kurimasa; Toshiaki Inoue; Fumiaki Ayabe; Kotaro Shibata; Junya Toguchida; Mitsuo Oshimura
A novel human artificial chromosome vector provides effective cell lineage-specific transgene expression in human mesenchymal stem cells.
Stem cells (Dayton, Ohio) 2005;23(10):1608-16.
2005: Tomitaka Nakayama; Tadao Tsuboyama; Junya Toguchida; Chiaki Tanaka; Natsuo Oya; Masahiro Hiraoka; Takashi Nakamura
Recurrence of osteosarcoma after intraoperative radiation therapy.
Orthopedics 2005;28(10):1195-7.
2005: Satoshi Nagayama; Chikako Fukukawa; Toyomasa Katagiri; Takeshi Okamoto; Tomoki Aoyama; Naoki Oyaizu; Masayuki Imamura; Junya Toguchida; Yusuke Nakamura
Therapeutic potential of antibodies against FZD 10, a cell-surface protein, for synovial sarcomas.
Oncogene 2005;24(41):6201-12.
2005: Tomohiro Handa; Sonoko Nagai; Isao Ito; Rollin P Tabuena; Michio Shigematsu; Kunio Hamada; Masanori Kitaichi; Takateru Izumi; Tomoki Aoyama; Junya Toguchida; Michiaki Mishima
Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis.
Respiration; international review of thoracic diseases 2005;72(3):243-8.
2005: Tatsuya Ishibe; Tomitaka Nakayama; Takeshi Okamoto; Tomoki Aoyama; Koichi Nishijo; Kotaro Roberts Shibata; Yasuko Shima; Satoshi Nagayama; Toyomasa Katagiri; Yusuke Nakamura; Takashi Nakamura; Junya Toguchida
Disruption of fibroblast growth factor signal pathway inhibits the growth of synovial sarcomas: potential application of signal inhibitors to molecular target therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(7):2702-12.
2005: Tomoki Aoyama; Bojian Liang; Takeshi Okamoto; Takashi Matsusaki; Koichi Nishijo; Tatsuya Ishibe; Ko Yasura; Satoshi Nagayama; Tomitaka Nakayama; Takashi Nakamura; Junya Toguchida
PGE2 signal through EP2 promotes the growth of articular chondrocytes.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(3):377-89.
2004: Koichi Nishijo; Tomitaka Nakayama; Tomoki Aoyama; Takeshi Okamoto; Tatsuya Ishibe; Ko Yasura; Yasuko Shima; Kotaro R Shibata; Tadao Tsuboyama; Takashi Nakamura; Junya Toguchida
Mutation analysis of the RECQL4 gene in sporadic osteosarcomas.
International journal of cancer. Journal international du cancer 2004;111(3):367-72.
2004: Satoshi Nagayama; Megumi Iiizumi; Toyomasa Katagiri; Junya Toguchida; Yusuke Nakamura
Identification of PDZK4, a novel human gene with PDZ domains, that is upregulated in synovial sarcomas.
Oncogene 2004;23(32):5551-7.
2004: Tomoki Aoyama; Takeshi Okamoto; Satoshi Nagayama; Koichi Nishijo; Tatsuya Ishibe; Ko Yasura; Tomitaka Nakayama; Takashi Nakamura; Junya Toguchida
Methylation in the core-promoter region of the chondromodulin-I gene determines the cell-specific expression by regulating the binding of transcriptional activator Sp3.
The Journal of biological chemistry 2004;279(27):28789-97.
2004: Tomitaka Nakayama; Mizuki Nishino; Kosho Takasu; Katsumi Hayakawa; Junya Toguchida; Chiaki Tanaka
Endovascular papillary angioendothelioma (Dabska tumor) of bone.
Orthopedics 2004;27(3):327-8.
2004: Kensuke Ochi; Yataro Daigo; Toyomasa Katagiri; Satoshi Nagayama; Tatsuhiko Tsunoda; Akira Myoui; Norifumi Naka; Nobuto Araki; Ikuo Kudawara; Makoto Ieguchi; Yoshiaki Toyama; Junya Toguchida; Hideki Yoshikawa; Yusuke Nakamura
Prediction of response to neoadjuvant chemotherapy for osteosarcoma by gene-expression profiles.
International journal of oncology 2004;24(3):647-55.
2004: Tomoki Aoyama; Takeshi Okamoto; Satoshi Nagayama; Koichi Nishijo; Tatsuya Ishibe; Ko Yasura; Tadao Tsuboyama; Tomitaka Nakayama; Yasuaki Nakashima; Takashi Nakamura; Junya Toguchida
Expression of the chondromodulin-I gene in chondrosarcomas.
Cancer letters 2004;204(1):61-8.
2004: Kazuyasu Ushio; Masanori Oka; Suong-Hyu Hyon; Tadashi Hayami; Shigeo Yura; Kazuaki Matsumura; Junya Toguchida; Takashi Nakamura
Attachment of artificial cartilage to underlying bone.
Journal of biomedical materials research. Part B, Applied biomaterials 2004;68(1):59-68.
2003: Tsuyoshi Imai; Souichi Adachi; Koichi Nishijo; Masatoshi Ohgushi; Masayuki Okada; Takahiro Yasumi; Ken-ichiro Watanabe; Ryuta Nishikomori; Tomitaka Nakayama; Shin Yonehara; Junya Toguchida; Tatsutoshi Nakahata
FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells.
Oncogene 2003;22(58):9231-42.
2003: Kazuyasu Ushio; Masanori Oka; Suong-Hyu Hyon; Shigeo Yura; Junya Toguchida; Tetsuya Nakamura
Partial hemiarthroplasty for the treatment of osteonecrosis of the femoral head. An experimental study in the dog.
The Journal of bone and joint surgery. British volume 2003;85(6):922-30.
2003: Rebecca Sowers; Junya Toguchida; Jing Qin; Paul A Meyers; John Healey; Andrew G Huvos; Debabrata Banerjee; Joseph R Bertino; Richard Gorlick
mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma.
Molecular cancer therapeutics 2003;2(6):535-41.
2003: Takeshi Okamoto; Junya Toguchida; Takashi Nakamura
[Tissue engineering for bone and cartilage repair].
Nihon rinsho. Japanese journal of clinical medicine 2003;61(3):432-8.
2003: Masanori Kobayashi; Junya Toguchida; Masanori Oka
Development of an artificial meniscus using polyvinyl alcohol-hydrogel for early return to, and continuance of, athletic life in sportspersons with severe meniscus injury. II: animal experiments.
The Knee 2003;10(1):53.
2003: Masanori Kobayashi; Junya Toguchida; Masanori Oka
Development of an artificial meniscus using polyvinyl alcohol-hydrogel for early return to, and continuance of, athletic life in sportspersons with severe meniscus injury. I: mechanical evaluation.
The Knee 2003;10(1):47-51.
2003: Masanori Kobayashi; Junya Toguchida; Masanori Oka
Preliminary study of polyvinyl alcohol-hydrogel (PVA-H) artificial meniscus.
Biomaterials 2003;24(4):639-47.
2003: Takeharu Nakamata; Tomoki Aoyama; Takeshi Okamoto; Taisuke Hosaka; Koichi Nishijo; Tomitaka Nakayama; Takashi Nakamura; Junya Toguchida
In vitro demonstration of cell-to-cell interaction in growth plate cartilage using chondrocytes established from p53-/- mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(1):97-107.
2002: Tomoki Aoyama; Satoshi Nagayama; Takeshi Okamoto; Taisuke Hosaka; Takeharu Nakamata; Koichi Nishijo; Tadao Tsuboyama; Tomitaka Nakayama; Takashi Nakamura; Junya Toguchida
Mutation analyses of the NFAT1 gene in chondrosarcomas and enchondromas.
Cancer letters 2002;186(1):49-57.
2002: Hidefumi Nishimori; Yasushi Sasaki; Koichi Yoshida; Hideto Irifune; Hitoshi Zembutsu; Toshihiro Tanaka; Tomoki Aoyama; Taisuke Hosaka; Satoshi Kawaguchi; Takuro Wada; Jun-Ichi Hata; Junya Toguchida; Yusuke Nakamura; Takashi Tokino
The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors.
Oncogene 2002;21(54):8302-9.
2002: Satoshi Nagayama; Hisashi Onodera; Junya Toguchida; Masayuki Imamura
Altered expression of the receptor and ligand in the TGF beta signaling pathway in diffusely infiltrating colon carcinoma.
Anticancer research 2002;22(6B):3545-54.
2002: Satoshi Nagayama; Toyomasa Katagiri; Tatsuhiko Tsunoda; Taisuke Hosaka; Yasuaki Nakashima; Nobuhito Araki; Katsuyuki Kusuzaki; Tomitaka Nakayama; Tadao Tsuboyama; Takashi Nakamura; Masayuki Imamura; Yusuke Nakamura; Junya Toguchida
Genome-wide analysis of gene expression in synovial sarcomas using a cDNA microarray.
Cancer research 2002;62(20):5859-66.
2002: Hiroshi Murakami; Tomitaka Nakayama; Koichi Nishijo; Taisuke Hosaka; Takeharu Nakamata; Tomoki Aoyama; Takeshi Okamoto; Tadao Tsuboyama; Takashi Nakamura; Junya Toguchida
Morphological and biological heterogeneity of three tumorigenic cell lines derived from a single p53-/- osteoblast-like cell line, MMC2.
Cancer letters 2002;182(2):203-11.
2002: Hideharu Domoto; Taisuke Hosaka; Kosuke Oikawa; Tetsuya Ohbayashi; Tsuyoshi Ishida; Miki Izumi; Keiichi Iwaya; Junya Toguchida; Masahiko Kuroda; Kiyoshi Mukai
TLS-CHOP target gene DOL54 expression in liposarcomas and malignant fibrous histiocytomas.
Pathology international 2002;52(8):497-500.
2002: Taisuke Hosaka; Yasuaki Nakashima; Katsuyuki Kusuzaki; Hiroaki Murata; Tomitaka Nakayama; Takeharu Nakamata; Tomoki Aoyama; Takeshi Okamoto; Koichi Nishijo; Nobuhito Araki; Tadao Tsuboyama; Takashi Nakamura; Junya Toguchida
A novel type of EWS-CHOP fusion gene in two cases of myxoid liposarcoma.
The Journal of molecular diagnostics : JMD 2002;4(3):164-71.
2002: Takeshi Okamoto; Tomoki Aoyama; Tomitaka Nakayama; Takeharu Nakamata; Taisuke Hosaka; Koichi Nishijo; Takashi Nakamura; Tohru Kiyono; Junya Toguchida
Clonal heterogeneity in differentiation potential of immortalized human mesenchymal stem cells.
Biochemical and biophysical research communications 2002;295(2):354-61.
2002: Shohei Kondo; Hisashi Onodera; Shugen Kan; Shigeki Uchida; Junya Toguchida; Masayuki Imamura
Intramuscular metastasis from gastric cancer.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2002;5(2):107-11.
2001: Masanori Kobayashi; Junya Toguchida; Masanori Oka
Development of polyvinyl alcohol-hydrogel (PVA-H) shields with a high water content for tendon injury repair.
Journal of hand surgery (Edinburgh, Scotland) 2001;26(5):436-40.
2001: Natsuo Oya; Masaki Kokubo; Takashi Mizowaki; Yuta Shibamoto; Yasushi Nagata; Keisuke Sasai; Yasumasa Nishimura; Tadao Tsuboyama; Junya Toguchida; Tetsuya Nakamura; Masahiro Hiraoka
Definitive intraoperative very high-dose radiotherapy for localized osteosarcoma in the extremities.
International journal of radiation oncology, biology, physics 2001;51(1):87-93.
2001: Masanori Kobayashi; Junya Toguchida; Masanori Oka
Study on the lubrication mechanism of natural joints by confocal laser scanning microscopy.
Journal of biomedical materials research 2001;55(4):645-51.
2001: Masanori Kobayashi; Junya Toguchida; Masanori Oka
Development of the shields for tendon injury repair using polyvinyl alcohol--hydrogel ( PVA-H).
Journal of biomedical materials research 2001;58(4):344-51.
2000: Taisuke Hosaka; H Kanoe; Tomitaka Nakayama; Hiroshi Murakami; Hidetaka Yamamoto; Takeharu Nakamata; Tadao Tsuboyama; M Oka; M Kasai; Masao S Sasaki; Tetsuya Nakamura; Junya Toguchida
Translin binds to the sequences adjacent to the breakpoints of the TLS and CHOP genes in liposarcomas with translocation t(12;6).
Oncogene 2000;19(50):5821-5.
2000: Junya Toguchida; S Nagayama
[Multiple exostoses].
Nihon rinsho. Japanese journal of clinical medicine 2000;58(7):1473-8.
2000: Hidetaka Yamamoto; Tomitaka Nakayama; Hiroshi Murakami; Taisuke Hosaka; Takeharu Nakamata; Tadao Tsuboyama; M Oka; Tetsuya Nakamura; Junya Toguchida
High incidence of SV40-like sequences detection in tumour and peripheral blood cells of Japanese osteosarcoma patients.
British journal of cancer 2000;82(10):1677-81.
2000: Tadao Tsuboyama; Junya Toguchida; Y Kotoura; K Kasahara; M Hiraoka; Tetsuya Nakamura
Intra-operative radiation therapy for osteosarcoma in the extremities.
International orthopaedics 2000;24(4):202-7.
1999: H Sugita; Masanori Oka; Junya Toguchida; Tetsuya Nakamura; Toyoji Ueo; Tadashi Hayami
Anisotropy of osteoporotic cancellous bone.
Bone 1999;24(5):513-6.
1999: H Kanoe; Tomitaka Nakayama; Taisuke Hosaka; Hiroshi Murakami; Hidetaka Yamamoto; Yasuaki Nakashima; Tadao Tsuboyama; Tetsuya Nakamura; D Ron; Masao S Sasaki; Junya Toguchida
Characteristics of genomic breakpoints in TLS-CHOP translocations in liposarcomas suggest the involvement of Translin and topoisomerase II in the process of translocation.
Oncogene 1999;18(3):721-9.
1998: H Kanoe; Tomitaka Nakayama; Hiroshi Murakami; Taisuke Hosaka; Hidetaka Yamamoto; Yasuaki Nakashima; Tadao Tsuboyama; Tetsuya Nakamura; Masao S Sasaki; Junya Toguchida
Amplification of the CDK4 gene in sarcomas: tumor specificity and relationship with the RB gene mutation.
Anticancer research 1998;18(4A):2317-21.
1997: Masanori Oka; YS Chang; Tetsuya Nakamura; Kazuyasu Ushio; Junya Toguchida; HO Gu
Synthetic osteochondral replacement of the femoral articular surface.
The Journal of bone and joint surgery. British volume 1997;79(6):1003-7.
1997: YS Chang; Masanori Oka; HO Gu; Masanori Kobayashi; Junya Toguchida; Tetsuya Nakamura; Tadashi Hayami
Histologic comparison of tibial articular surfaces against rigid materials and artificial articular cartilage.
Journal of biomedical materials research 1997;37(1):51-9.
1997: Tomitaka Nakayama; H Kanoe; Masao S Sasaki; S Aizawa; Tetsuya Nakamura; Junya Toguchida
Establishment of an osteoblast-like cell line, MMC2, from p53-deficient mice.
Bone 1997;21(4):313-9.
1996: K Shimizu; M Matsushita; S Fujibayashi; Junya Toguchida; K Ido; T Nakamura
Correction of kyphotic deformity of the cervical spine in ankylosing spondylitis using general anesthesia and internal fixation.
Journal of spinal disorders 1996;9(6):540-3.
1996: Tomitaka Nakayama; Junya Toguchida; B Wadayama; H Kanoe; S Aizawa; M S Sasaki; T Nakamura
Fracture healing is a process independent of p53 function.
In vivo (Athens, Greece) 1996;10(6):553-8.
1996: M V Kato; T Shimizu; K Ishizaki; A Kaneko; D W Yandell; Junya Toguchida; M S Sasaki
Loss of heterozygosity on chromosome 17 and mutation of the p53 gene in retinoblastoma.
Cancer letters 1996;106(1):75-82.
1996: T Yamaguchi; Junya Toguchida; B Wadayama; H Kanoe; Tomitaka Nakayama; Kanji Ishizaki; Mituo Ikenaga; Y Kotoura; M S Sasaki
Loss of heterozygosity and tumor suppressor gene mutations in chondrosarcomas.
Anticancer research 1996;16(4A):2009-15.
1995: Tomitaka Nakayama; Junya Toguchida; B Wadayama; H Kanoe; Y Kotoura; M S Sasaki
MDM2 gene amplification in bone and soft-tissue tumors: association with tumor progression in differentiated adipose-tissue tumors.
International journal of cancer. Journal international du cancer 1995;64(5):342-6.
1995: M V Kato; Kanji Ishizaki; T Shimizu; Junya Toguchida; A Kaneko; M S Sasaki
Delayed development of retinoblastoma associated with loss of a maternal allele on chromosome 13.
International journal of cancer. Journal international du cancer 1995;64(1):3-8.
1994: M V Kato; Kanji Ishizaki; T Shimizu; Yosuke Ejima; Hiroshi Tanooka; J Takayama; A Kaneko; Junya Toguchida; M S Sasaki
Parental origin of germ-line and somatic mutations in the retinoblastoma gene.
Human genetics 1994;94(1):31-8.
1994: B Wadayama; Junya Toguchida; T Shimizu; Kanji Ishizaki; M S Sasaki; Y Kotoura; T Yamamuro
Mutation spectrum of the retinoblastoma gene in osteosarcomas.
Cancer research 1994;54(11):3042-8.
1994: T Shimizu; Junya Toguchida; M V Kato; A Kaneko; Kanji Ishizaki; M S Sasaki
Detection of mutations of the RB1 gene in retinoblastoma patients by using exon-by-exon PCR-SSCP analysis.
American journal of human genetics 1994;54(5):793-800.
1994: M V Kato; Kanji Ishizaki; Junya Toguchida; A Kaneko; J Takayama; Hiroshi Tanooka; T Kato; T Shimizu; M S Sasaki
Mutations in the retinoblastoma gene and their expression in somatic and tumor cells of patients with hereditary retinoblastoma.
Human mutation 1994;3(1):44-51.
1993: B Wadayama; Junya Toguchida; T Yamaguchi; M S Sasaki; T Yamamuro
p53 expression and its relationship to DNA alterations in bone and soft tissue sarcomas.
British journal of cancer 1993;68(6):1134-9.
1993: Junya Toguchida; T L McGee; J C Paterson; J R Eagle; S Tucker; D W Yandell; Thaddeus P Dryja
Complete genomic sequence of the human retinoblastoma susceptibility gene.
Genomics 1993;17(3):535-43.
1993: Tomonori Habuchi; R Takahashi; H Yamada; Osamu Ogawa; Yoshiyuki Kakehi; K Ogura; S Hamazaki; Junya Toguchida; Kanji Ishizaki; J Fujita
Influence of cigarette smoking and schistosomiasis on p53 gene mutation in urothelial cancer.
Cancer research 1993;53(16):3795-9.
1993: T Wagata; I Shibagaki; Masayuki Imamura; Yutaka Shimada; Junya Toguchida; D W Yandell; Mituo Ikenaga; T Tobe; Kanji Ishizaki
Loss of 17p, mutation of the p53 gene, and overexpression of p53 protein in esophageal squamous cell carcinomas.
Cancer research 1993;53(4):846-50.
1993: N Nishida; Y Fukuda; H Kokuryu; Junya Toguchida; D W Yandell; M Ikenega; Hiroshi Imura; Kanji Ishizaki
Role and mutational heterogeneity of the p53 gene in hepatocellular carcinoma.
Cancer research 1993;53(2):368-72.
1992: H Nakai; S Misawa; Junya Toguchida; D W Yandell; K Ishizaki
Frequent p53 gene mutations in blast crisis of chronic myelogenous leukemia, especially in myeloid crisis harboring loss of a chromosome 17p.
Cancer research 1992;52(23):6588-93.
1992: Junya Toguchida; T Yamaguchi; B Ritchie; R L Beauchamp; S H Dayton; G E Herrera; T Yamamuro; Y Kotoura; M S Sasaki; J B Little
Mutation spectrum of the p53 gene in bone and soft tissue sarcomas.
Cancer research 1992;52(22):6194-9.
1992: M Sugimoto; Junya Toguchida; Y Kotoura; T Yamamuro; H Utsumi
Intrinsic radiosensitivity and PLD repair in osteosarcoma cell lines.
International journal of radiation biology 1992;62(4):469-74.
1992: Junya Toguchida; T Yamaguchi; S H Dayton; R L Beauchamp; G E Herrera; K Ishizaki; T Yamamuro; Paul A Meyers; J B Little; M S Sasaki
Prevalence and spectrum of germline mutations of the p53 gene among patients with sarcoma.
The New England journal of medicine 1992;326(20):1301-8.
1992: T Yamaguchi; Junya Toguchida; T Yamamuro; Y Kotoura; N Takada; N Kawaguchi; Y Kaneko; Yoshimasa Nakamura; M S Sasaki; Kanji Ishizaki
Allelotype analysis in osteosarcomas: frequent allele loss on 3q, 13q, 17p, and 18q.
Cancer research 1992;52(9):2419-23.
1991: M S Sasaki; M Kato; Junya Toguchida; T Yamaguchi; Yosuke Ejima; Kanji Ishizaki; A Kaneko; Hiroshi Tanooka
Somatic and germinal mutations of tumor-suppressor genes in the development of cancer.
Journal of radiation research 1991;32 Suppl 2():266-76.
1991: T Sakai; Junya Toguchida; N Ohtani; D W Yandell; J M Rapaport; Thaddeus P Dryja
Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene.
American journal of human genetics 1991;48(5):880-8.
1991: M Sugimoto; S Takahashi; Junya Toguchida; Y Kotoura; Yuta Shibamoto; T Yamamuro
Changes in bone after high-dose irradiation. Biomechanics and histomorphology.
The Journal of bone and joint surgery. British volume 1991;73(3):492-7.
1990: G L Vaughn; Junya Toguchida; T L McGee; Thaddeus P Dryja
PCR detection of the Tth 111 I RFLP at the RB locus.
Nucleic acids research 1990;18(16):4965.
1990: M Kato; Junya Toguchida; K Honda; M S Sasaki; Mituo Ikenaga; M Sugimoto; T Yamaguchi; Y Kotoura; T Yamamuro; Kanji Ishizaki
Elevated frequency of a specific allele of the L-myc gene in male patients with bone and soft-tissue sarcomas.
International journal of cancer. Journal international du cancer 1990;45(1):47-9.
1990: M S Sasaki; Yosuke Ejima; Junya Toguchida; M Kato; Kanji Ishizaki; Mituo Ikenaga
Germinal imprinting in chromosome mutation.
Progress in clinical and biological research 1990;340B():347-54.
1989: Junya Toguchida; Kanji Ishizaki; Yoshimasa Nakamura; M S Sasaki; Mituo Ikenaga; M Kato; M Sugimoto; Y Kotoura; T Yamamuro
Assignment of common allele loss in osteosarcoma to the subregion 17p13.
Cancer research 1989;49(22):6247-51.
1989: M S Sasaki; Junya Toguchida
[Loss of heterozygosity in the progression of tumors].
Gan to kagaku ryoho. Cancer & chemotherapy 1989;16(10):3347-53.
1989: H R Chang; Kanji Ishizaki; M S Sasaki; Junya Toguchida; M Kato; Y Nakamura; S Kawamura; T Moriguchi; Mituo Ikenaga
Somatic mosaicism for DNA repair capacity in fibroblasts derived from a group A xeroderma pigmentosum patient.
The Journal of investigative dermatology 1989;93(4):460-5.
1989: Junya Toguchida; Kanji Ishizaki; M S Sasaki; Y Nakamura; Mituo Ikenaga; M Kato; M Sugimot; Y Kotoura; T Yamamuro
Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcoma.
Nature 1989;338(6211):156-8.
1989: M Sasaki; Yosuke Ejima; Kanji Ishizaki; Junya Toguchida; M Kato
[Recessive oncogene and loss of heterozygosity].
Gan to kagaku ryoho. Cancer & chemotherapy 1989;16(3 Pt 2):624-31.
1988: T Tsuji; T Yamamuro; Y Kotoura; M Matsumoto; H Tanaka; C Tanaka; Junya Toguchida; Keigo Endo; Harumi Sakahara; M Koizumi
Uptake of 99Tcm-MDP in lung metastasis from osteosarcoma: clinical and animal studies.
Nuclear medicine communications 1988;9(12):947-54.
1988: K Honda; Kanji Ishizaki; M Ikenaga; Junya Toguchida; T Inamoto; K Tanaka; K Ozawa
Increased frequency of specific alleles of the c-Ha-ras gene in Japanese cancer patients.
Human genetics 1988;79(4):297-300.
1988: Junya Toguchida; Kanji Ishizaki; M S Sasaki; Mituo Ikenaga; M Sugimoto; Y Kotoura; T Yamamuro
Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma.
Cancer research 1988;48(14):3939-43.