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Chiharu Tohyama

Research Profile

Chemicals & Drugs

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Reverse Transcriptase Polymerase Chain Reaction

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TOP 3
Hisaka Kurita; Seiichiroh Ohsako; Shin-ichi Hashimoto; Jun Yoshinaga; Chiharu Tohyama
Prenatal zinc deficiency-dependent epigenetic alterations of mouse metallothionein-2 gene.
Wataru Yoshioka; Satoshi Uematsu; Keiko Aida-Yasuoka; Shizuo Akira; Nozomi Fujisawa; Shuntaro Hara; Tatsuya Kawaguchi; Seiichiroh Ohsako; Chiharu Tohyama
Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice.
Toshihiro Endo; Asahi Haijima; Masaki Kakeyama; Hiroyuki Okuno; Haruhiko Bito; Yukari Uemura; Chiharu Tohyama
Executive function deficits and social-behavioral abnormality in mice exposed to a low dose of dioxin in utero and via lactation.

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All Publications

2013: Hisaka Kurita; Seiichiroh Ohsako; Shin-ichi Hashimoto; Jun Yoshinaga; Chiharu Tohyama
Prenatal zinc deficiency-dependent epigenetic alterations of mouse metallothionein-2 gene.
The Journal of nutritional biochemistry 2013;24(1):256-66.
2012: Wataru Yoshioka; Satoshi Uematsu; Keiko Aida-Yasuoka; Shizuo Akira; Nozomi Fujisawa; Shuntaro Hara; Tatsuya Kawaguchi; Seiichiroh Ohsako; Chiharu Tohyama
Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2012;127(2):547-54.
2012: Toshihiro Endo; Asahi Haijima; Masaki Kakeyama; Hiroyuki Okuno; Haruhiko Bito; Yukari Uemura; Chiharu Tohyama
Executive function deficits and social-behavioral abnormality in mice exposed to a low dose of dioxin in utero and via lactation.
PloS one 2012;7(12):e50741.
2012: Wataru Yoshioka; Nozomi Endo; Toshihiro Endo; Asahi Haijima; Masaki Kakeyama; Akie Kurashige; Ryutaro Nishiyama; Toshiyuki Shibata; Chiharu Tohyama
Fluorescence laser microdissection reveals a distinct pattern of gene activation in the mouse hippocampal region.
Scientific reports 2012;2():783.
2011: Wataru Yoshioka; Richard E Peterson; Chiharu Tohyama
Molecular targets that link dioxin exposure to toxicity phenotypes.
The Journal of steroid biochemistry and molecular biology 2011;127(1-2):96-101.
2011: Dorothy Tse; Hiroyuki Okuno; Tomonori Takeuchi; Chiharu Tohyama; Haruhiko Bito; YASUSHI KAJII; Masaki Kakeyama; Richard G M Morris
Schema-dependent gene activation and memory encoding in neocortex.
Science (New York, N.Y.) 2011;333(6044):891-5.
2011: Wataru Yoshioka; Wataru Higashiyama; Chiharu Tohyama
Involvement of microRNAs in dioxin-induced liver damage in the mouse.
Toxicological sciences : an official journal of the Society of Toxicology 2011;122(2):457-65.
2011: Toshihiro Endo; Fumihiko Maekawa; Vootele Voikar; Asahi Haijima; Yukari Uemura; Yan Zhang; Wataru Miyazaki; Shigetomo Suyama; Kuniko Shimazaki; David P Wolfer; T Yada; Chiharu Tohyama; Hans-Peter Lipp; Masaki Kakeyama
Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage.
Behavioural brain research 2011;221(1):172-81.
2011: Chiharu Tohyama; Iwao Uchiyama; Shuji Hoshi; Masaki Hijiya; Hideaki Miyata; Masaki Nagai; Satoshi Nakai; Mariko Yauchi; Satsuki Ohkubo
Polychlorinated dioxins, furans, and biphenyls in blood of children and adults living in a dioxin-contaminated area in Tokyo.
Environmental health and preventive medicine 2011;16(1):6-15.
2010: Asahi Haijima; Toshihiro Endo; Yan Zhang; Wataru Miyazaki; Masaki Kakeyama; Chiharu Tohyama
In utero and lactational exposure to low doses of chlorinated and brominated dioxins induces deficits in the fear memory of male mice.
Neurotoxicology 2010;31(4):385-90.
2010: Seiichiroh Ohsako; Noriho Fukuzawa; Ryuta Ishimura; Takashige Kawakami; Qing Wu; Reiko Nagano; Hiroko Zaha; Hideko Sone; Junzo Yonemoto; Chiharu Tohyama
Comparative contribution of the aryl hydrocarbon receptor gene to perinatal stage development and dioxin-induced toxicity between the urogenital complex and testis in the mouse.
Biology of reproduction 2010;82(3):636-43.
2010: Mohammad Shah Alam; Seiichiroh Ohsako; Takashi Matsuwaki; Xiao Bo Zhu; Naoki Tsunekawa; Yoshiakira Kanai; Hideko Sone; Chiharu Tohyama; Masamichi Kurohmaru
Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis: a possible estrogenic effect of di(n-butyl) phthalate.
Reproduction (Cambridge, England) 2010;139(2):427-37.
2009: Hisaka Kurita; Wataru Yoshioka; Noriko Nishimura; Naoto Kubota; Takashi Kadowaki; Chiharu Tohyama
Aryl hydrocarbon receptor-mediated effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on glucose-stimulated insulin secretion in mice.
Journal of applied toxicology : JAT 2009;29(8):689-94.
2009: Wataru Yoshioka; Toshiya Akagi; Noriko Nishimura; Hana Shimizu; Chiho Watanabe; Chiharu Tohyama
Severe toxicity and cyclooxygenase (COX)-2 mRNA increase by lithium in the neonatal mouse kidney.
The Journal of toxicological sciences 2009;34(5):519-25.
2009: Keiko Nohara; Takehiro Suzuki; Kana Ao; Hikari Murai; Yoshimi Miyamoto; Kaoru Inouye; Xiaoqing Pan; Hozumi Motohashi; Yoshiaki Fujii-Kuriyama; Masayuki Yamamoto; Chiharu Tohyama
Constitutively active aryl hydrocarbon receptor expressed in T cells increases immunization-induced IFN-gamma production in mice but does not suppress T(h)2-cytokine production or antibody production.
International immunology 2009;21(7):769-77.
2009: Takashige Kawakami; Tomohiro Ito; Seiichiroh Ohsako; Kazuhiro Shiizaki; Yoshitaka Murakami; Kazunari Hirowatari; Masao Sato; Chiharu Tohyama
Possible involvement of arylhydrocarbon receptor variants in TCDD-induced thymic atrophy and XRE-dependent transcriptional activity in Wistar Hannover GALAS rats.
The Journal of toxicological sciences 2009;34(2):209-20.
2009: Ryuta Ishimura; Takashige Kawakami; Seiichiroh Ohsako; Chiharu Tohyama
Dioxin-induced toxicity on vascular remodeling of the placenta.
Biochemical pharmacology 2009;77(4):660-9.
2009: Kana Ao; Takehiro Suzuki; Hikari Murai; Michiyo Matsumoto; Haruko Nagai; Yoshimi Miyamoto; Chiharu Tohyama; Keiko Nohara
Comparison of immunotoxicity among tetrachloro-, pentachloro-, tetrabromo- and pentabromo-dibenzo-p-dioxins in mice.
Toxicology 2009;256(1-2):25-31.
2008: Noriko Nishimura; Fumio Matsumura; Christopher F A Vogel; Hisao Nishimura; Junzo Yonemoto; Wataru Yoshioka; Chiharu Tohyama
Critical role of cyclooxygenase-2 activation in pathogenesis of hydronephrosis caused by lactational exposure of mice to dioxin.
Toxicology and applied pharmacology 2008;231(3):374-83.
2008: Rieko Hojo; Masaki Kakeyama; Yoshika Kurokawa; Yasunobu Aoki; Junzo Yonemoto; Chiharu Tohyama
Learning behavior in rat offspring after in utero and lactational exposure to either TCDD or PCB126.
Environmental health and preventive medicine 2008;13(3):169-80.
2008: Masaki Kakeyama; Hideko Sone; Chiharu Tohyama
Perinatal exposure of female rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces central precocious puberty in the offspring.
The Journal of endocrinology 2008;197(2):351-8.
2008: Tomohiro Ito; Kaoru Inouye; Keiko Nohara; Chiharu Tohyama; Hidekazu Fujimaki
TCDD exposure exacerbates atopic dermatitis-related inflammation in NC/Nga mice.
Toxicology letters 2008;177(1):31-7.
2008: Keiko Nohara; Kana Ao; Yoshimi Miyamoto; Takehiro Suzuki; Satoru Imaizumi; Yukiyo Tateishi; Seiichi Omura; Chiharu Tohyama; Takahiro Kobayashi
Arsenite-induced thymus atrophy is mediated by cell cycle arrest: a characteristic downregulation of E2F-related genes revealed by a microarray approach.
Toxicological sciences : an official journal of the Society of Toxicology 2008;101(2):226-38.
2007: Yoshinori Sakata; Wataru Yoshioka; Chiharu Tohyama; Seiichiroh Ohsako
Internal genomic sequence of human CYP1A1 gene is involved in superinduction of dioxin-induced CYP1A1 transcription by cycloheximide.
Biochemical and biophysical research communications 2007;355(3):687-92.
2006: Noriko Nishimura; Junzo Yonemoto; Hisao Nishimura; Chiharu Tohyama
Localization of cytochrome P450 1A1 in a specific region of hydronephrotic kidney of rat neonates lactationally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicology 2006;227(1-2):117-26.
2006: Keiko Nohara; Kana Ao; Yoshimi Miyamoto; Tomohiro Ito; Takehiro Suzuki; Hiroyoshi Toyoshiba; Chiharu Tohyama
Comparison of the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced CYP1A1 gene expression profile in lymphocytes from mice, rats, and humans: most potent induction in humans.
Toxicology 2006;225(2-3):204-13.
2006: Ryuta Ishimura; Takashige Kawakami; Seiichiroh Ohsako; Keiko Nohara; Chiharu Tohyama
Suppressive effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vascular remodeling that takes place in the normal labyrinth zone of rat placenta during late gestation.
Toxicological sciences : an official journal of the Society of Toxicology 2006;91(1):265-74.
2006: Takashige Kawakami; Ryuta Ishimura; Keiko Nohara; Ken Takeda; Chiharu Tohyama; Seiichiroh Ohsako
Differential susceptibilities of Holtzman and Sprague-Dawley rats to fetal death and placental dysfunction induced by 2,3,7,8-teterachlorodibenzo-p-dioxin (TCDD) despite the identical primary structure of the aryl hydrocarbon receptor.
Toxicology and applied pharmacology 2006;212(3):224-36.
2006: Tomohiro Ito; Haruko Nagai; Tien-Min Lin; Richard E Peterson; Chiharu Tohyama; Takahiro Kobayashi; Keiko Nohara
Organic Chemicals Adsorbed onto Diesel Exhaust Particles Directly Alter the Differentiation of Fetal Thymocytes Through Arylhydrocarbon Receptor but Not Oxidative Stress Responses.
Journal of immunotoxicology 2006;3(1):21-30.
2006: Chiharu Tohyama
[Exposure to dioxins in the environment and their health risk].
Nihon eiseigaku zasshi. Japanese journal of hygiene 2006;61(1):5-10.
2005: Kazuhiro Shiizaki; Seiichiroh Ohsako; Toshie Koyama; Ryoichi Nagata; Junzo Yonemoto; Chiharu Tohyama
Lack of CYP1A1 expression is involved in unresponsiveness of the human hepatoma cell line SK-HEP-1 to dioxin.
Toxicology letters 2005;160(1):22-33.
2005: Kaoru Inouye; Xiaoqing Pan; Noritaka Imai; Tomohiro Ito; Teiji Takei; Chiharu Tohyama; Keiko Nohara
T cell-derived IL-5 production is a sensitive target of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Chemosphere 2005;60(7):907-13.
2005: Masahiko Ikeda; Tetsuo Mitsui; Kaoru Setani; Masashi Tamura; Masaki Kakeyama; Hideko Sone; Chiharu Tohyama; Takako Tomita
In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats disrupts brain sexual differentiation.
Toxicology and applied pharmacology 2005;205(1):98-105.
2005: Noriko Nishimura; Junzo Yonemoto; Yuichi Miyabara; Yoshiaki Fujii-Kuriyama; Chiharu Tohyama
Altered thyroxin and retinoid metabolic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin in aryl hydrocarbon receptor-null mice.
Archives of toxicology 2005;79(5):260-7.
2005: Noriko Nishimura; Junzo Yonemoto; Hisao Nishimura; Shin-ichi Ikushiro; Chiharu Tohyama
Disruption of thyroid hormone homeostasis at weaning of Holtzman rats by lactational but not in utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicological sciences : an official journal of the Society of Toxicology 2005;85(1):607-14.
2005: Yuichi Miyabara; Noriko Nishimura; Chiharu Tohyama
Determination of dioxins in human hair: Estimation of external and internal exposure to dioxins.
Environmental health and preventive medicine 2005;10(2):86-93.
2005: Keiko Nohara; Xiaoqing Pan; Shin-ichi Tsukumo; Azumi Hida; Tomohiro Ito; Haruko Nagai; Kaoru Inouye; Hozumi Motohashi; Masayuki Yamamoto; Yoshiaki Fujii-Kuriyama; Chiharu Tohyama
Constitutively active aryl hydrocarbon receptor expressed specifically in T-lineage cells causes thymus involution and suppresses the immunization-induced increase in splenocytes.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):2770-7.
2005: Haruko Nagai; Teiji Takei; Chiharu Tohyama; Masato Kubo; Ryo Abe; Keiko Nohara
Search for the target genes involved in the suppression of antibody production by TCDD in C57BL/6 mice.
International immunopharmacology 2005;5(2):331-43.
2005: Junzo Yonemoto; Tutomu Ichiki; Teiji Takei; Chiharu Tohyama
Maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and the body burden in offspring of long-evans rats.
Environmental health and preventive medicine 2005;10(1):21-32.
2005: Chiharu Tohyama; Rie Masho
[The establishment of tolerable intake levels and the current situation of the risk assessment of dioxin and related compounds].
Nihon eiseigaku zasshi. Japanese journal of hygiene 2005;60(1):60-9.
2004: Xiaoqing Pan; Kaoru Inouye; Tomohiro Ito; Haruko Nagai; Yoko Takeuchi; Yuichi Miyabara; Chiharu Tohyama; Keiko Nohara
Evaluation of relative potencies of PCB126 and PCB169 for the immunotoxicities in ovalbumin (OVA)-immunized mice.
Toxicology 2004;204(1):51-60.
2004: Noriho H Fukuzawa; Seiichiroh Ohsako; Qing Wu; Motoharu Sakaue; Yoshiaki Fujii-Kuriyama; Tadashi Baba; Chiharu Tohyama
Testicular cytochrome P450scc and LHR as possible targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the mouse.
Molecular and cellular endocrinology 2004;221(1-2):87-96.
2004: Tomohiro Ito; Shin-ichi Tsukumo; Norio Suzuki; Hozumi Motohashi; Masayuki Yamamoto; Yoshiaki Fujii-Kuriyama; Junsei Mimura; Tien-Min Lin; Richard E Peterson; Chiharu Tohyama; Keiko Nohara
A constitutively active arylhydrocarbon receptor induces growth inhibition of jurkat T cells through changes in the expression of genes related to apoptosis and cell cycle arrest.
The Journal of biological chemistry 2004;279(24):25204-10.
2004: Qing Wu; Seiichiroh Ohsako; Ryuta Ishimura; Junko S Suzuki; Chiharu Tohyama
Exposure of mouse preimplantation embryos to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters the methylation status of imprinted genes H19 and Igf2.
Biology of reproduction 2004;70(6):1790-7.
2004: Takahiro Kusumegi; Junko Tanaka; Michihiro Kawano; Junzo Yonemoto; Chiharu Tohyama; Hideko Sone
BMP7/ActRIIB regulates estrogen-dependent apoptosis: new biomarkers for environmental estrogens.
Journal of biochemical and molecular toxicology 2004;18(1):1-11.
2003: Kunihiro Kubota; Seiichiroh Ohsako; Shuichi Kurosawa; Ken Takeda; Wu Qing; Motoharu Sakaue; Takashige Kawakami; Ryuta Ishimura; Chiharu Tohyama
Effects of vinclozolin administration on sperm production and testosterone biosynthetic pathway in adult male rat.
The Journal of reproduction and development 2003;49(5):403-12.
2003: Seiichiroh Ohsako; Kunihiro Kubota; Shuichi Kurosawa; Ken Takeda; Wu Qing; Ryuta Ishimura; Chiharu Tohyama
Alterations of gene expression in adult male rat testis and pituitary shortly after subacute administration of the antiandrogen flutamide.
The Journal of reproduction and development 2003;49(4):275-90.
2003: Kaoru Inouye; Tomohiro Ito; Hidekazu Fujimaki; Yoshimasa Takahashi; Toshitada Takemori; Xiaoqing Pan; Chiharu Tohyama; Keiko Nohara
Suppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the high-affinity antibody response in C57BL/6 mice.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(2):315-24.
2003: Masaki Kakeyama; Chiharu Tohyama
Developmental neurotoxicity of dioxin and its related compounds.
Industrial health 2003;41(3):215-30.
2003: Hirotoshi Doi; Tadashi Baba; Chiharu Tohyama; Keiko Nohara
Functional activation of arylhydrocarbon receptor (AhR) in primary T cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Chemosphere 2003;52(4):655-62.
2003: Junko S Suzuki; Noriko Nishimura; Baoxu Zhang; Yoko Nakatsuru; Shizuko Kobayashi; Masahiko Satoh; Chiharu Tohyama
Metallothionein deficiency enhances skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate in metallothionein-null mice.
Carcinogenesis 2003;24(6):1123-32.
2003: Noriho H Fukuzawa; Seiichiroh Ohsako; R Nagano; Motoharu Sakaue; T Baba; Yasunobu Aoki; Chiharu Tohyama
Effects of 3,3',4,4',5-pentachlorobiphenyl, a coplanar polychlorinated biphenyl congener, on cultured neonatal mouse testis.
Toxicology in vitro : an international journal published in association with BIBRA 2003;17(3):259-69.
2003: Takashi Moriguchi; Hozumi Motohashi; Tomonori Hosoya; Osamu Nakajima; Satoru Takahashi; Seiichiroh Ohsako; Yasunobu Aoki; Noriko Nishimura; Chiharu Tohyama; Yoshiaki Fujii-Kuriyama; Masayuki Yamamoto
Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):5652-7.
2003: Noriko Nishimura; Junzo Yonemoto; Yuichi Miyabara; Mikio Sato; Chiharu Tohyama
Rat thyroid hyperplasia induced by gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Endocrinology 2003;144(5):2075-83.
2003: Mie Murata; Noriko Nishimura; Baoxu Zhang; Masahiko Satoh; Chiharu Tohyama
Interleukin-6 protects skin lesion caused by 7,12-dimethylbenz[a]anthracene.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2003;65(4):511-3.
2003: Masaki Kakeyama; Hideko Sone; Yuichi Miyabara; Chiharu Tohyama
Perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters activity-dependent expression of BDNF mRNA in the neocortex and male rat sexual behavior in adulthood.
Neurotoxicology 2003;24(2):207-17.
2003: Mayumi Ishizuka; Junzo Yonemoto; Hiroko Zaha; Chiharu Tohyama; Hideko Sone
Perinatal exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin alters sex-dependent expression of hepatic CYP2C11.
Journal of biochemical and molecular toxicology 2003;17(5):278-85.
2002: Ryuta Ishimura; Seiichiroh Ohsako; Takashige Kawakami; Motoharu Sakaue; Yasunobu Aoki; Chiharu Tohyama
Altered protein profile and possible hypoxia in the placenta of 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed rats.
Toxicology and applied pharmacology 2002;185(3):197-206.
2002: Tomohiro Ito; Kaoru Inouye; Hidekazu Fujimaki; Chiharu Tohyama; Keiko Nohara
Mechanism of TCDD-induced suppression of antibody production: effect on T cell-derived cytokine production in the primary immune reaction of mice.
Toxicological sciences : an official journal of the Society of Toxicology 2002;70(1):46-54.
2002: Shin-ichi Tsukumo; Makoto Iwata; Chiharu Tohyama; Keiko Nohara
Skewed differentiation of thymocytes toward CD8 T cells by 2,3,7,8-tetrachlorodibenzo- p-dioxin requires activation of the extracellular signal-related kinase pathway.
Archives of toxicology 2002;76(5-6):335-43.
2002: Qing Wu; Seiichiroh Ohsako; Tadashi Baba; Kyoko Miyamoto; Chiharu Tohyama
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on preimplantation mouse embryos.
Toxicology 2002;174(2):119-29.
2002: Seiichiroh Ohsako; Yuichi Miyabara; Motoharu Sakaue; Ryuta Ishimura; Masaki Kakeyama; Hiroyuki Izumi; Junzo Yonemoto; Chiharu Tohyama
Developmental stage-specific effects of perinatal 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on reproductive organs of male rat offspring.
Toxicological sciences : an official journal of the Society of Toxicology 2002;66(2):283-92.
2002: Makoto Kurachi; Shin-ichi Hashimoto; Aya Obata; Shigenori Nagai; Tomoyuki Nagahata; Hidekuni Inadera; Hideko Sone; Chiharu Tohyama; Shuichi Kaneko; Ken-ichi Kobayashi; Kouji Matsushima
Identification of 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive genes in mouse liver by serial analysis of gene expression.
Biochemical and biophysical research communications 2002;292(2):368-77.
2002: Keiko Nohara; Hidekazu Fujimaki; Shin-ichi Tsukumo; Kaoru Inouye; Hideko Sone; Chiharu Tohyama
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on T cell-derived cytokine production in ovalbumin (OVA)-immunized C57Bl/6 mice.
Toxicology 2002;172(1):49-58.
2002: Hidekazu Fujimaki; Keiko Nohara; Takahiro Kobayashi; K Suzuki; K Eguchi-Kasai; Shin-ichi Tsukumo; M Kijima; Chiharu Tohyama
Effect of a single oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin on immune function in male NC/Nga mice.
Toxicological sciences : an official journal of the Society of Toxicology 2002;66(1):117-24.
2002: Noriko Nishimura; Yuichi Miyabara; Mikio Sato; Junzo Yonemoto; Chiharu Tohyama
Immunohistochemical localization of thyroid stimulating hormone induced by a low oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats.
Toxicology 2002;171(2-3):73-82.
2002: Motoharu Sakaue; Ryuta Ishimura; Shuichi Kurosawa; Noriho H Fukuzawa; Masamichi Kurohmaru; Yoshihiro Hayashi; Chiharu Tohyama; Seiichiroh Ohsako
Administration of estradiol-3-benzoate down-regulates the expression of testicular steroidogenic enzyme genes for testosterone production in the adult rat.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2002;64(2):107-13.
2002: Ryuta Ishimura; Seiichiroh Ohsako; Yuichi Miyabara; Motoharu Sakaue; Takashige Kawakami; Yasunobu Aoki; Junzo Yonemoto; Chiharu Tohyama
Increased glycogen content and glucose transporter 3 mRNA level in the placenta of Holtzman rats after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicology and applied pharmacology 2002;178(3):161-71.
2002: Keiko Nohara; Hiroyuki Izumi; Shin ichi Tamura; Ryoichi Nagata; Chiharu Tohyama
Effect of low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on influenza A virus-induced mortality in mice.
Toxicology 2002;170(1-2):131-8.
2002: Masahiko Ikeda; Naomi Inukai; Tetsuo Mitsui; Hideko Sone; Chiharu Tohyama; Junzo Yonemoto; Takako Tomita
Changes in fetal brain aromatase activity following in utero 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in rats.
Environmental toxicology and pharmacology 2002;11(1):1-7.
2002: Masahiko Satoh; Hiroshi Koyama; Toshiyuki Kaji; Hideaki Kito; Chiharu Tohyama
Perspectives on cadmium toxicity research.
The Tohoku journal of experimental medicine 2002;196(1):23-32.
2001: Masaki Kakeyama; Hideko Sone; Chiharu Tohyama
Changes in expression of NMDA receptor subunit mRNA by perinatal exposure to dioxin.
Neuroreport 2001;12(18):4009-12.
2001: Noriko Nishimura; Yuichi Miyabara; Junko S Suzuki; Mikio Sato; Yasunobu Aoki; Masahiko Satoh; Junzo Yonemoto; Chiharu Tohyama
Induction of metallothionein in the livers of female Sprague-Dawley rats treated with 2,3,7 ,8-tetrachlorodibenzo-p-dioxin.
Life sciences 2001;69(11):1291-303.
2001: H Takanaga; M Kunimoto; T Adachi; Chiharu Tohyama; Yasunobu Aoki
Inhibitory effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cAMP-induced differentiation of rat C6 glial cell line.
Journal of neuroscience research 2001;64(4):402-9.
2001: Seiichiroh Ohsako; Yuichi Miyabara; Noriko Nishimura; S Kurosawa; Motoharu Sakaue; Ryuta Ishimura; Mikio Sato; Ken Takeda; Yasunobu Aoki; Hideko Sone; Chiharu Tohyama; Junzo Yonemoto
Maternal exposure to a low dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppressed the development of reproductive organs of male rats: dose-dependent increase of mRNA levels of 5alpha-reductase type 2 in contrast to decrease of androgen receptor in the pubertal ventral prostate.
Toxicological sciences : an official journal of the Society of Toxicology 2001;60(1):132-43.
2000: Masahiko Satoh; Akinori Shimada; Baoxu Zhang; Chiharu Tohyama
Renal toxicity caused by cisplatinum in glutathione-depleted metallothionein-null mice.
Biochemical pharmacology 2000;60(11):1729-34.
2000: Keiko Nohara; Hidekazu Fujimaki; Shin-ichi Tsukumo; H Ushio; Yuichi Miyabara; M Kijima; Chiharu Tohyama; Junzo Yonemoto
The effects of perinatal exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin on immune organs in rats.
Toxicology 2000;154(1-3):123-33.
2000: Keiko Nohara; H Ushio; Shin-ichi Tsukumo; Takahiro Kobayashi; M Kijima; Chiharu Tohyama; Hidekazu Fujimaki
Alterations of thymocyte development, thymic emigrants and peripheral T cell population in rats exposed to 2,3,7, 8-tetrachlorodibenzo-p-dioxin.
Toxicology 2000;145(2-3):227-35.
2000: Noriko Nishimura; V E Reeve; H Nishimura; Masahiko Satoh; Chiharu Tohyama
Cutaneous metallothionein induction by ultraviolet B irradiation in interleukin-6 null mice.
The Journal of investigative dermatology 2000;114(2):343-8.
2000: A Molotkov; Masahiko Satoh; Chiharu Tohyama
Induction of hepatic metallothioneins in tumor-bearing IL-6-null mice.
Oncology research 2000;12(4):169-72.
2000: A Molotkov; Noriko Nishimura; Masahiko Satoh; Chiharu Tohyama
Role of IL-6 in the induction of hepatic metallothionein in mice after partial hepatectomy.
Life sciences 2000;66(11):963-70.
1999: N Nishimura; Chiharu Tohyama; M Satoh; H Nishimura; V E Reeve
Defective immune response and severe skin damage following UVB irradiation in interleukin-6-deficient mice.
Immunology 1999;97(1):77-83.
1998: A Molotkov; Masahiko Satoh; Chiharu Tohyama
Tumor growth and food intake in interleukin-6 gene knock-out mice.
Cancer letters 1998;132(1-2):187-92.
1998: Osamu Tsutsumi; H Uechi; Hirohito Sone; J Yonemoto; Yasushi Takai; Mikio Momoeda; Chiharu Tohyama; Shin-ichi Hashimoto; M Morita; Yuji Taketani
Presence of dioxins in human follicular fluid: their possible stage-specific action on the development of preimplantation mouse embryos.
Biochemical and biophysical research communications 1998;250(2):498-501.
1998: Baoxu Zhang; Masahiko Satoh; Noriko Nishimura; Junko S Suzuki; H Sone; Yasunobu Aoki; Chiharu Tohyama
Metallothionein deficiency promotes mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene.
Cancer research 1998;58(18):4044-6.
1998: Junko S Suzuki; N Kodama; A Molotkov; E Aoki; Chiharu Tohyama
Isolation and identification of metallothionein isoforms (MT-1 and MT-2) in the rat testis.
The Biochemical journal 1998;334 ( Pt 3)():695-701.
1998: M Ishido; S Homma-Takeda; Chiharu Tohyama; T Suzuki
Apoptosis in rat renal proximal tubular cells induced by cadmium.
Journal of toxicology and environmental health. Part A 1998;55(1):1-12.
1998: M Ishido; Chiharu Tohyama; T Suzuki
c-myc is not involved in cadmium-elicited apoptotic pathway in porcine kidney LLC-PK1 cells.
Life sciences 1998;63(14):1195-204.
1997: Margarita Dimitrova Apostolova; KH Choo; AE Michalska; Chiharu Tohyama
Analysis of the possible protective role of metallothionein in streptozotocin-induced diabetes using metallothionein-null mice.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 1997;11(1):1-7.
1997: Masahiko Satoh; Yasunobu Aoki; Chiharu Tohyama
Protective role of metallothionein in renal toxicity of cisplatinum.
Cancer chemotherapy and pharmacology 1997;40(4):358-62.
1996: Chiharu Tohyama; Junko S Suzuki; S Homma; M Karasawa; T Kuroki; H Nishimura; N Nishimura
Testosterone-dependent induction of metallothionein in genital organs of male rats.
The Biochemical journal 1996;317 ( Pt 1)():97-102.
1996: Chiharu Tohyama; H Nishimura; M Satoh; A Choo; Y Kanayama; N Kodama; A Michalska; A Naganuma
Reduced retention of cadmium in the liver of metallothionein-null mice.
Environmental toxicology and pharmacology 1996;1(3):213-6.
1996: S Kobayashi; M Takehana; Chiharu Tohyama
Glutathione isopropyl ester reduces UVB-induced skin damage in hairless mice.
Photochemistry and photobiology 1996;63(1):106-10.
1995: B Zhang; J S Suzuki; N Nishimura; Chiharu Tohyama
Difference in cadmium cytotoxicity in two kidney cell lines (LLC-PK(1) and MDCK) with special reference to metallothionein.
Toxicology in vitro : an international journal published in association with BIBRA 1995;9(5):765-72.
1995: Masami Ishido; S T Homma; P S Leung; Chiharu Tohyama
Cadmium-induced DNA fragmentation is inhibitable by zinc in porcine kidney LLC-PK1 cells.
Life sciences 1995;56(17):PL351-6.
1994: S Kobayashi; Y Hirota; J Sayato-Suzuki; M Takehana; H Nishimura; N Nishimura; Chiharu Tohyama
Possible role of metallothionein in the cellular defense mechanism against UVB irradiation in neonatal human skin fibroblasts.
Photochemistry and photobiology 1994;59(6):650-6.
1994: Chiharu Tohyama; N Nishimura; Junko S Suzuki; M Karasawa; H Nishimura
Metallothionein mRNA in the testis and prostate of the rat detected by digoxigenin-labeled riboprobe.
Histochemistry 1994;101(5):341-6.
1993: Chiharu Tohyama; J S Suzuki; J Hemelraad; N Nishimura; H Nishimura
Induction of metallothionein and its localization in the nucleus of rat hepatocytes after partial hepatectomy.
Hepatology (Baltimore, Md.) 1993;18(5):1193-201.
1991: Y Aoki; Chiharu Tohyama; K T Suzuki
A western blotting procedure for detection of metallothionein.
Journal of biochemical and biophysical methods 1991;23(3):207-16.
1988: Chiharu Tohyama; Y Mitane; E Kobayashi; N Sugihira; A Nakano; H Saito
The relationships of urinary metallothionein with other indicators of renal dysfunction in people living in a cadmium-polluted area in Japan.
Journal of applied toxicology : JAT 1988;8(1):15-21.
1987: Chiharu Tohyama; N Sugihira; H Saito
Critical concentration of cadmium for renal toxicity in rats.
Journal of toxicology and environmental health 1987;22(3):255-9.
1986: N Sugihira; Chiharu Tohyama; M Murakami; H Saito
Significance of increase in urinary metallothionein of rats repeatedly exposed to cadmium.
Toxicology 1986;41(1):1-9.
1986: Chiharu Tohyama; E Kobayashi; H Saito; N Sugihara; A Nakano; Y Mitane
Urinary alpha 1-microglobulin as an indicator protein of renal tubular dysfunction caused by environmental cadmium exposure.
Journal of applied toxicology : JAT 1986;6(3):171-8.
1986: Y Mitane; Chiharu Tohyama; H Saito
The role of metallothionein in the elevated excretion of copper in urine from people living in a cadmium-polluted area.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1986;6(2):285-91.