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Johannes Bos

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Lars A T Meijer; shabaz mohammed; Houjiang Zhou; Marco L Hennrich; A F Maarten Altelaar; Johannes L Bos; On Ying A Chan; Albert J R Heck
Quantitative global phosphoproteomics of human umbilical vein endothelial cells after activation of the Rap signaling pathway.
Willem-Jan Pannekoek; Johannes L Bos; Patricia M Brouwer; Jelena R Linnemann; Holger Rehmann
Rap1 and Rap2 antagonistically control endothelial barrier resistance.
Martijn Gloerich; Thijs Koorman; Jean Paul ten Klooster; Marjolein J Vliem; Fried J Zwartkruis; Hans Clevers; Johannes L Bos
Rap2A links intestinal cell polarity to brush border formation.

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2013: Lars A T Meijer; shabaz mohammed; Houjiang Zhou; Marco L Hennrich; A F Maarten Altelaar; Johannes L Bos; On Ying A Chan; Albert J R Heck
Quantitative global phosphoproteomics of human umbilical vein endothelial cells after activation of the Rap signaling pathway.
Molecular bioSystems 2013;9(4):732-49.
2013: Willem-Jan Pannekoek; Johannes L Bos; Patricia M Brouwer; Jelena R Linnemann; Holger Rehmann
Rap1 and Rap2 antagonistically control endothelial barrier resistance.
PloS one 2013;8(2):e57903.
2012: Martijn Gloerich; Thijs Koorman; Jean Paul ten Klooster; Marjolein J Vliem; Fried J Zwartkruis; Hans Clevers; Johannes L Bos
Rap2A links intestinal cell polarity to brush border formation.
Nature cell biology 2012;14(8):793-801.
2012: Sarah V Consonni; Martijn Gloerich; Emma Spanjaard; Johannes L Bos
cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(10):3814-9.
2012: Johannes L Bos; Willem-Jan Pannekoek
Semaphorin signaling meets rap.
Science signaling 2012;5(212):pe6.
2012: Sarah H Ross; Emma Spanjaard; Marjolein J Vliem; Johannes L Bos; Hendy Kristyanto; Anneke Post; Johan de Rooij
Rap1 can bypass the FAK-Src-Paxillin cascade to induce cell spreading and focal adhesion formation.
PloS one 2012;7(11):e50072.
2011: Willem-Jan Pannekoek; Holger Rehmann; Emma Spanjaard; Anne Jan van der Meer; Jantine J G van Dijk; Fried J T Zwartkruis; Patricia M Brouwer; On Ying A Chan; Johan de Rooij; Stephan Huveneers; Jelena R Linnemann; Johannes L Bos
Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control.
Cellular signalling 2011;23(12):2056-64.
2011: Martijn Gloerich; Johannes L Bos
Regulating Rap small G-proteins in time and space.
Trends in cell biology 2011;21(10):615-23.
2011: Martijn Gloerich; Lars A T Meijer; Esther Prummel; Holger Rehmann; Marije G A Rensen; Marjolein J Vliem; Johannes L Bos
The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.
The Journal of cell biology 2011;193(6):1009-20.
2011: Sarah H Ross; Anneke Post; Judith H Raaijmakers; Ingrid Verlaan; Martijn Gloerich; Johannes L Bos
Ezrin is required for efficient Rap1-induced cell spreading.
Journal of cell science 2011;124(Pt 11):1808-18.
2011: Mirjam T Epping; Lars A T Meijer; Oscar Krijgsman; Johannes L Bos; Pier Paolo Pandolfi; René Bernards
TSPYL5 suppresses p53 levels and function by physical interaction with USP7.
Nature cell biology 2011;13(1):102-8.
2010: Martijn Gloerich; Bas Ponsioen; Marjolein J Vliem; Zhongchun Zhang; Jun Zhao; Matthijs R H Kooistra; Leo S Price; Laila Ritsma; Fried J Zwartkruis; Holger Rehmann; Kees Jalink; Johannes L Bos
Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins.
Molecular and cellular biology 2010;30(22):5421-31.
2010: Martijn Gloerich; Johannes L Bos
Epac: defining a new mechanism for cAMP action.
Annual review of pharmacology and toxicology 2010;50():355-75.
2009: Teunis J P van Dam; Holger Rehmann; Johannes L Bos; Berend Snel
Phylogeny of the CDC25 homology domain reveals rapid differentiation of Ras pathways between early animals and fungi.
Cellular signalling 2009;21(11):1579-85.
2009: Bas Ponsioen; Martijn Gloerich; Laila Ritsma; Holger Rehmann; Johannes L Bos; Kees Jalink
Direct spatial control of Epac1 by cyclic AMP.
Molecular and cellular biology 2009;29(10):2521-31.
2009: Judith H Raaijmakers; Johannes L Bos
Specificity in Ras and Rap signaling.
The Journal of biological chemistry 2009;284(17):10995-9.
2009: Willem-Jan Pannekoek; Matthijs R H Kooistra; Fried J T Zwartkruis; Johannes L Bos
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
Biochimica et biophysica acta 2009;1788(4):790-6.
2008: Magdalena J Lorenowicz; Mar Fernandez-Borja; Matthijs R H Kooistra; Johannes L Bos; Peter L Hordijk
PKA and Epac1 regulate endothelial integrity and migration through parallel and independent pathways.
European journal of cell biology 2008;87(10):779-92.
2008: Holger Rehmann; Ernesto Arias-Palomo; Michael A Hadders; Frank Schwede; Oscar Llorca; Johannes L Bos
Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B.
Nature 2008;455(7209):124-7.
2008: Marjolein J Vliem; Bas Ponsioen; Frank Schwede; Willem-Jan Pannekoek; Jurgen Riedl; Matthijs R H Kooistra; Kees Jalink; Hans-Gottfried Genieser; Johannes L Bos; Holger Rehmann
8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue.
Chembiochem : a European journal of chemical biology 2008;9(13):2052-4.
2008: Nadia Dubé; Matthijs R H Kooistra; Willem-Jan Pannekoek; Marjolein J Vliem; Viola Oorschot; Judith Klumperman; Holger Rehmann; Johannes L Bos
The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctions.
Cellular signalling 2008;20(9):1608-15.
2008: Karen S Lyle; Judith H Raaijmakers; Wytse Bruinsma; Johannes L Bos; Johan de Rooij
cAMP-induced Epac-Rap activation inhibits epithelial cell migration by modulating focal adhesion and leading edge dynamics.
Cellular signalling 2008;20(6):1104-16.
2008: Heiko Poppe; Sergei D Rybalkin; Holger Rehmann; Thomas R Hinds; Xiao-Bo Tang; Anne E Christensen; Frank Schwede; Hans-Gottfried Genieser; Johannes L Bos; Stein O Doskeland; Joseph A Beavo; Elke Butt
Cyclic nucleotide analogs as probes of signaling pathways.
Nature methods 2008;5(4):277-8.
2008: Shannon M Harper; Hans Wienk; Rainer Wechselberger; Johannes L Bos; Rolf Boelens; Holger Rehmann
Structural dynamics in the activation of Epac.
The Journal of biological chemistry 2008;283(10):6501-8.
2007: Ester W Frische; Wendy Pellis-van Berkel; Gijs van Haaften; Edwin Cuppen; Ronald H Plasterk; Marcel Tijsterman; Johannes L Bos; Fried J T Zwartkruis
RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans.
The EMBO journal 2007;26(24):5083-92.
2007: Johannes L Bos; Holger Rehmann; Alfred Wittinghofer
GEFs and GAPs: critical elements in the control of small G proteins.
Cell 2007;129(5):865-77.
2007: Judith H Raaijmakers; Laurence Deneubourg; Holger Rehmann; John de Koning; Zhongchun Zhang; Sonja Krugmann; Christophe Erneux; Johannes L Bos
The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner.
Cellular signalling 2007;19(6):1249-57.
2007: Holger Rehmann; Alfred Wittinghofer; Johannes L Bos
Capturing cyclic nucleotides in action: snapshots from crystallographic studies.
Nature reviews. Molecular cell biology 2007;8(1):63-73.
2007: Matthijs R H Kooistra; Nadia Dubé; Johannes L Bos
Rap1: a key regulator in cell-cell junction formation.
Journal of cell science 2007;120(Pt 1):17-22.
2006: Johannes L Bos
Epac proteins: multi-purpose cAMP targets.
Trends in biochemical sciences 2006;31(12):680-6.
2006: Guoxin Kang; Oleg G Chepurny; Brian Malester; Michael J Rindler; Holger Rehmann; Johannes L Bos; Frank Schwede; William A Coetzee; George G Holz
cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells.
The Journal of physiology 2006;573(Pt 3):595-609.
2006: Holger Rehmann; Joost Das; Puck Knipscheer; Alfred Wittinghofer; Johannes L Bos
Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state.
Nature 2006;439(7076):625-8.
2006: Marta Roccio; Johannes L Bos; Fried J T Zwartkruis
Regulation of the small GTPase Rheb by amino acids.
Oncogene 2006;25(5):657-64.
2005: Takahiro Nobukuni; Manel Joaquin; Marta Roccio; Stephen G Dann; So Young Kim; Pawan Gulati; Maya P Byfield; Jonathan M Backer; Francois Natt; Johannes L Bos; Fried J T Zwartkruis; George Thomas
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(40):14238-43.
2005: Zhongchun Zhang; Holger Rehmann; Leo S Price; Jurgen Riedl; Johannes L Bos
AF6 negatively regulates Rap1-induced cell adhesion.
The Journal of biological chemistry 2005;280(39):33200-5.
2005: Matthijs R H Kooistra; Monica Corada; Elisabetta Dejana; Johannes L Bos
Epac1 regulates integrity of endothelial cell junctions through VE-cadherin.
FEBS letters 2005;579(22):4966-72.
2005: Jurgen Riedl; Dominique T Brandt; Eduard Batlle; Leo S Price; Hans Clevers; Johannes L Bos
Down-regulation of Rap1 activity is involved in ephrinB1-induced cell contraction.
The Biochemical journal 2005;389(Pt 2):465-9.
2005: Johannes L Bos
Linking Rap to cell adhesion.
Current opinion in cell biology 2005;17(2):123-8.
2005: H Bea Kuiperij; Armando van der Horst; Jan A M Raaijmakers; Sanne Weijzen; René H Medema; Johannes L Bos; Boudewijn M T Burgering; Fried J T Zwartkruis
Activation of FoxO transcription factors contributes to the antiproliferative effect of cAMP.
Oncogene 2005;24(12):2087-95.
2005: Wendy Pellis-van Berkel; M H G Verheijen; Edwin Cuppen; M Asahina; Johan de Rooij; G Jansen; Ronald H Plasterk; Johannes L Bos; Fried J T Zwartkruis
Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity.
Molecular biology of the cell 2005;16(1):106-16.
2004: Marieke A G Essers; Sanne Weijzen; Alida M M de Vries-Smits; Ingrid Saarloos; Nancy D de Ruiter; Johannes L Bos; Boudewijn M T Burgering
FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.
The EMBO journal 2004;23(24):4802-12.
2004: Bas Ponsioen; Jun Zhao; Jurgen Riedl; Fried J T Zwartkruis; Gerard van der Krogt; Manuela Zaccolo; Wouter H Moolenaar; Johannes L Bos; Kees Jalink
Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator.
EMBO reports 2004;5(12):1176-80.
2004: Jorrit M Enserink; Leo S Price; Trond Methi; Milada Mahic; Arnoud Sonnenberg; Johannes L Bos; Kjetil Taskén
The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin.
The Journal of biological chemistry 2004;279(43):44889-96.
2004: Leo S Price; Johannes L Bos
RAPL: taking the Rap in immunity.
Nature immunology 2004;5(10):1007-8.
2004: Johannes L Bos; Boudewijn M T Burgering
Molecular mechanisms in signal transduction and cancer.
EMBO reports 2004;5(9):855-9.
2004: Leo S Price; Amra Hajdo-Milasinovic; Jun Zhao; Fried J T Zwartkruis; John G Collard; Johannes L Bos
Rap1 regulates E-cadherin-mediated cell-cell adhesion.
The Journal of biological chemistry 2004;279(34):35127-32.
2004: P H J Remans; Sonja I Gringhuis; Jacob M van Laar; Marjolein E Sanders; Ellen A M Papendrecht-van der Voort; Fried J T Zwartkruis; E W Nivine Levarht; Marcela Rosas; Paul J Coffer; Ferdinand C Breedveld; Johannes L Bos; Paul P Tak; Cornelis L Verweij; Kris A Reedquist
Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):920-31.
2004: Holger Rehmann; Johannes L Bos
Signal transduction: thumbs up for inactivation.
Nature 2004;429(6988):138-9.
2004: Miranda van Triest; Johannes L Bos
Pull-down assays for guanoside 5'-triphosphate-bound Ras-like guanosine 5'-triphosphatases.
Methods in molecular biology (Clifton, N.J.) 2004;250():97-102.
2004: Tobias B Dansen; Geert J P L Kops; Simone Denis; Nannette Jelluma; Ronald J A Wanders; Johannes L Bos; Boudewijn M T Burgering; Karel W A Wirtz
Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3a.
Journal of lipid research 2004;45(1):81-8.
2003: Holger Rehmann; Frank Schwede; Stein Ove Døskeland; Alfred Wittinghofer; Johannes L Bos
Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac.
The Journal of biological chemistry 2003;278(40):38548-56.
2003: Anne E Christensen; Frode Selheim; Johan de Rooij; Sarah Dremier; Frank Schwede; Khanh K Dao; Aurora Martinez; Carine Maenhaut; Johannes L Bos; Hans-Gottfried Genieser; Stein Ove Døskeland
cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension.
The Journal of biological chemistry 2003;278(37):35394-402.
2003: Johannes L Bos
Epac: a new cAMP target and new avenues in cAMP research.
Nature reviews. Molecular cell biology 2003;4(9):733-8.
2003: Holger Rehmann; Alma Rueppel; Johannes L Bos; Alfred Wittinghofer
Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac.
The Journal of biological chemistry 2003;278(26):23508-14.
2003: Kim M T de Bruyn; Fried J T Zwartkruis; Johan de Rooij; Jan-Willem N Akkerman; Johannes L Bos
The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes.
The Journal of biological chemistry 2003;278(25):22412-7.
2003: Attila Garami; Fried J T Zwartkruis; Takahiro Nobukuni; Manel Joaquin; Marta Roccio; Hugo Stocker; Sara C Kozma; Ernst Hafen; Johannes L Bos; George Thomas
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.
Molecular cell 2003;11(6):1457-66.
2003: Guoxin Kang; Jamie W Joseph; Oleg G Chepurny; Marie Monaco; Michael B Wheeler; Johannes L Bos; Frank Schwede; Hans-Gottfried Genieser; George G Holz
Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.
The Journal of biological chemistry 2003;278(10):8279-85.
2003: H Bea Kuiperij; Johan de Rooij; Holger Rehmann; Miranda van Triest; Alfred Wittinghofer; Johannes L Bos; Fried J T Zwartkruis
Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2.
Biochimica et biophysica acta 2003;1593(2-3):141-9.
2003: Savithri Rangarajan; Jorrit M Enserink; H Bea Kuiperij; Johan de Rooij; Leo S Price; Frank Schwede; Johannes L Bos
Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor.
The Journal of cell biology 2003;160(4):487-93.
2003: Johannes L Bos; Kim M T de Bruyn; Jorrit M Enserink; B Kuiperij; Savithri Rangarajan; Holger Rehmann; Jurgen Riedl; Johan de Rooij; F van Mansfeld; Fried J T Zwartkruis
The role of Rap1 in integrin-mediated cell adhesion.
Biochemical Society transactions 2003;31(Pt 1):83-6.
2003: Holger Rehmann; Balaji Prakash; Eva Wolf; Alma Rueppel; Johan de Rooij; Johannes L Bos; Alfred Wittinghofer
Structure and regulation of the cAMP-binding domains of Epac2.
Nature structural biology 2003;10(1):26-32.
2002: Jorrit M Enserink; Anne E Christensen; Johan de Rooij; Miranda van Triest; Frank Schwede; Hans-Gottfried Genieser; Stein Ove Døskeland; Jonathan L Blank; Johannes L Bos
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.
Nature cell biology 2002;4(11):901-6.
2002: Geert J P L Kops; Tobias B Dansen; Paulien E Polderman; Ingrid Saarloos; Karel W A Wirtz; Paul J Coffer; Ting-T Huang; Johannes L Bos; René H Medema; Boudewijn M T Burgering
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress.
Nature 2002;419(6904):316-21.
2002: Kim M T de Bruyn; Savithri Rangarajan; Kris A Reedquist; Carl G Figdor; Johannes L Bos
The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion.
The Journal of biological chemistry 2002;277(33):29468-76.
2002: D Margriet Ouwens; Nancy D de Ruiter; Gerard C M van der Zon; Andrew P Carter; Jan Schouten; Corina van der Burgt; Klaas Kooistra; Johannes L Bos; J Antonie Maassen; Hans van Dam
Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38.
The EMBO journal 2002;21(14):3782-93.
2001: Nancy D de Ruiter; Boudewijn M T Burgering; Johannes L Bos
Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451.
Molecular and cellular biology 2001;21(23):8225-35.
2001: Johannes L Bos; Johan de Rooij; Kris A Reedquist
Rap1 signalling: adhering to new models.
Nature reviews. Molecular cell biology 2001;2(5):369-77.
2001: A Kraemer; Holger Rehmann; Robbert Cool; C Theiss; Johan de Rooij; Johannes L Bos; Alfred Wittinghofer
Dynamic interaction of cAMP with the Rap guanine-nucleotide exchange factor Epac1.
Journal of molecular biology 2001;306(5):1167-77.
2001: Miranda van Triest; Johan de Rooij; Johannes L Bos
Measurement of GTP-bound Ras-like GTPases by activation-specific probes.
Methods in enzymology 2001;333():343-8.
2000: Nancy D de Ruiter; RM Wolthuis; Hans van Dam; Boudewijn M T Burgering; Johannes L Bos
Ras-dependent regulation of c-Jun phosphorylation is mediated by the Ral guanine nucleotide exchange factor-Ral pathway.
Molecular and cellular biology 2000;20(22):8480-8.
2000: D Amsen; Ada M Kruisbeek; Johannes L Bos; Kris A Reedquist
Activation of the Ras-related GTPase Rap1 by thymocyte TCR engagement and during selection.
European journal of immunology 2000;30(10):2832-41.
2000: Kim M T de Bruyn; Johan de Rooij; RM Wolthuis; Holger Rehmann; J Wesenbeek; Robbert Cool; Alfred Wittinghofer; Johannes L Bos
RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral.
The Journal of biological chemistry 2000;275(38):29761-6.
2000: Lingge Lu; Cecilia Annerén; Kris A Reedquist; Johannes L Bos; Michael Welsh
NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway.
Experimental cell research 2000;259(2):370-7.
2000: Cecilia Annerén; Kris A Reedquist; Johannes L Bos; Michael Welsh
GTK, a Src-related tyrosine kinase, induces nerve growth factor-independent neurite outgrowth in PC12 cells through activation of the Rap1 pathway. Relationship to Shb tyrosine phosphorylation and elevated levels of focal adhesion kinase.
The Journal of biological chemistry 2000;275(37):29153-61.
2000: Johan de Rooij; Holger Rehmann; Miranda van Triest; Robbert Cool; Alfred Wittinghofer; Johannes L Bos
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.
The Journal of biological chemistry 2000;275(27):20829-36.
2000: Christian M Hackeng; B Franke; Ingrid A M Relou; Gertie Gorter; Johannes L Bos; Herman J M van Rijn; Jan-Willem N Akkerman
Low-density lipoprotein activates the small GTPases Rap1 and Ral in human platelets.
The Biochemical journal 2000;349(Pt 1):231-8.
2000: René H Medema; Geert J P L Kops; Johannes L Bos; Boudewijn M T Burgering
AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1.
Nature 2000;404(6779):782-7.
2000: Kris A Reedquist; E Ross; E A Koop; RM Wolthuis; Fried J T Zwartkruis; Yvette van Kooyk; M Salmon; C D Buckley; Johannes L Bos
The small GTPase, Rap1, mediates CD31-induced integrin adhesion.
The Journal of cell biology 2000;148(6):1151-8.
2000: B Franke; Miranda van Triest; K M de Bruijn; Gijsbert van Willigen; H Karel Nieuwenhuis; C Negrier; Jan-Willem N Akkerman; Johannes L Bos
Sequential regulation of the small GTPase Rap1 in human platelets.
Molecular and cellular biology 2000;20(3):779-85.
2000: Sarah Dremier; Fabrice Vandeput; F J Zwartkruis; Johannes L Bos; Jacques E Dumont; Carine Maenhaut
Activation of the small G protein Rap1 in dog thyroid cells by both cAMP-dependent and -independent pathways.
Biochemical and biophysical research communications 2000;267(1):7-11.
1999: Johan de Rooij; N M Boenink; Miranda van Triest; Robbert Cool; Alfred Wittinghofer; Johannes L Bos
PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2.
The Journal of biological chemistry 1999;274(53):38125-30.
1999: Fried J T Zwartkruis; Johannes L Bos
Ras and Rap1: two highly related small GTPases with distinct function.
Experimental cell research 1999;253(1):157-65.
1999: M Spaargaren; Johannes L Bos
Rab5 induces Rac-independent lamellipodia formation and cell migration.
Molecular biology of the cell 1999;10(10):3239-50.
1999: WT Steegenga; N Riteco; Johannes L Bos
Infectivity and expression of the early adenovirus proteins are important regulators of wild-type and DeltaE1B adenovirus replication in human cells.
Oncogene 1999;18(36):5032-43.
1999: M H G Verheijen; RM Wolthuis; Libert H K Defize; Jeroen den Hertog; Johannes L Bos
Interdependent action of RalGEF and Erk in Ras-induced primitive endoderm differentiation of F9 embryonal carcinoma cells.
Oncogene 1999;18(31):4435-9.
1999: L M'Rabet; Paul J Coffer; RM Wolthuis; Fried J T Zwartkruis; Leo Koenderman; Johannes L Bos
Differential fMet-Leu-Phe- and platelet-activating factor-induced signaling toward Ral activation in primary human neutrophils.
The Journal of biological chemistry 1999;274(31):21847-52.
1999: WT Steegenga; A Shvarts; N Riteco; Johannes L Bos; Aart G Jochemsen
Distinct regulation of p53 and p73 activity by adenovirus E1A, E1B, and E4orf6 proteins.
Molecular and cellular biology 1999;19(5):3885-94.
1999: Geert J P L Kops; Nancy D de Ruiter; Alida M M de Vries-Smits; D R Powell; Johannes L Bos; Boudewijn M T Burgering
Direct control of the Forkhead transcription factor AFX by protein kinase B.
Nature 1999;398(6728):630-4.
1999: Vanessa Nancy; RM Wolthuis; MF de Tand; Isabelle Janoueix-Lerosey; Johannes L Bos; Jean de Gunzburg
Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2.
The Journal of biological chemistry 1999;274(13):8737-45.
1999: RM Wolthuis; Johannes L Bos
Ras caught in another affair: the exchange factors for Ral.
Current opinion in genetics & development 1999;9(1):112-7.
1999: M H G Verheijen; RM Wolthuis; Johannes L Bos; Libert H K Defize
The Ras/Erk pathway induces primitive endoderm but prevents parietal endoderm differentiation of F9 embryonal carcinoma cells.
The Journal of biological chemistry 1999;274(3):1487-94.
1998: Johan de Rooij; Fried J T Zwartkruis; M H G Verheijen; Robbert Cool; S M Nijman; Alfred Wittinghofer; Johannes L Bos
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.
Nature 1998;396(6710):474-7.
1998: Johannes L Bos
All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral.
The EMBO journal 1998;17(23):6776-82.
1998: Fried J T Zwartkruis; RM Wolthuis; N M Nabben; B Franke; Johannes L Bos
Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling.
The EMBO journal 1998;17(20):5905-12.
1998: L M'Rabet; Paul J Coffer; Fried J T Zwartkruis; B Franke; A W Segal; Leo Koenderman; Johannes L Bos
Activation of the small GTPase rap1 in human neutrophils.
Blood 1998;92(6):2133-40.
1998: LH Aarts; Loes H Schrama; WJ Hage; Johannes L Bos; Willem Hendrik Gispen; P Schotman
B-50/GAP-43-induced formation of filopodia depends on Rho-GTPase.
Molecular biology of the cell 1998;9(6):1279-92.
1998: DH van Weering; T C Moen; Ineke Braakman; P D Baas; Johannes L Bos
Expression of the receptor tyrosine kinase Ret on the plasma membrane is dependent on calcium.
The Journal of biological chemistry 1998;273(20):12077-81.
1998: RM Wolthuis; B Franke; Miranda van Triest; B Bauer; Robbert Cool; Jacques Camonis; Jan-Willem N Akkerman; Johannes L Bos
Activation of the small GTPase Ral in platelets.
Molecular and cellular biology 1998;18(5):2486-91.
1998: RM Wolthuis; Fried J T Zwartkruis; T C Moen; Johannes L Bos
Ras-dependent activation of the small GTPase Ral.
Current biology : CB 1998;8(8):471-4.
1998: DH van Weering; Johan de Rooij; B Marte; J Downward; Johannes L Bos; Boudewijn M T Burgering
Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras.
Molecular and cellular biology 1998;18(4):1802-11.
1998: Kris A Reedquist; Johannes L Bos
Costimulation through CD28 suppresses T cell receptor-dependent activation of the Ras-like small GTPase Rap1 in human T lymphocytes.
The Journal of biological chemistry 1998;273(9):4944-9.
1998: WT Steegenga; N Riteco; Aart G Jochemsen; F J Fallaux; Johannes L Bos
The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells.
Oncogene 1998;16(3):349-57.
1998: DH van Weering; Johannes L Bos
Signal transduction by the receptor tyrosine kinase Ret.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1998;154():271-81.
1997: Paul J Coffer; AA van Puijenbroek; Boudewijn M T Burgering; M Klop-de Jonge; Leo Koenderman; Johannes L Bos; Wiebe Kruijer
Insulin activates Stat3 independently of p21ras-ERK and PI-3K signal transduction.
Oncogene 1997;15(21):2529-39.
1997: RM Wolthuis; Nancy D de Ruiter; Robbert Cool; Johannes L Bos
Stimulation of gene induction and cell growth by the Ras effector Rlf.
The EMBO journal 1997;16(22):6748-61.
1997: Johannes L Bos
Ras-like GTPases.
Biochimica et biophysica acta 1997;1333(2):M19-31.
1997: Johannes L Bos; B Franke; L M'Rabet; Kris A Reedquist; Fried J T Zwartkruis
In search of a function for the Ras-like GTPase Rap1.
FEBS letters 1997;410(1):59-62.
1997: AA van Puijenbroek; DH van Weering; Stieneke van den Brink; Johannes L Bos; Paul T van der Saag; SW De Laat; Jeroen den Hertog
Cell scattering of SK-N-MC neuroepithelioma cells in response to Ret and FGF receptor tyrosine kinase activation is correlated with sustained ERK2 activation.
Oncogene 1997;14(10):1147-57.
1997: Johan de Rooij; Johannes L Bos
Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras.
Oncogene 1997;14(5):623-5.
1997: B Franke; Jan-Willem N Akkerman; Johannes L Bos
Rapid Ca2+-mediated activation of Rap1 in human platelets.
The EMBO journal 1997;16(2):252-9.
1997: DH van Weering; Johannes L Bos
Glial cell line-derived neurotrophic factor induces Ret-mediated lamellipodia formation.
The Journal of biological chemistry 1997;272(1):249-54.
1997: J Dorrestijn; Johannes L Bos; Gerard C M van der Zon; J Antonie Maassen
Changes in the signalling status of the small GTP-binding proteins Rac and Rho do not influence insulin-stimulated hexose transport.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1997;105(5):254-62.
1996: RM Wolthuis; B Bauer; L J van 't Veer; Alida M M de Vries-Smits; Robbert Cool; M Spaargaren; Alfred Wittinghofer; Boudewijn M T Burgering; Johannes L Bos
RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein.
Oncogene 1996;13(2):353-62.
1996: J Dorrestijn; D M Ouwens; N Van den Berghe; Johannes L Bos; J Antonie Maassen
Expression of a dominant-negative Ras mutant does not affect stimulation of glucose uptake and glycogen synthesis by insulin.
Diabetologia 1996;39(5):558-63.
1996: Maikel Peppelenbosch; Leon Tertoolen; Alida M M de Vries-Smits; R G Qiu; L M'Rabet; Marc Symons; SW De Laat; Johannes L Bos
Rac-dependent and -independent pathways mediate growth factor-induced Ca2+ influx.
The Journal of biological chemistry 1996;271(14):7883-6.
1996: J P Medema; G J Pronk; Alida M M de Vries-Smits; R Clark; F McCormick; Johannes L Bos
Insulin-induced tyrosine phosphorylation of a M(r) 70,000 protein revealed by association with the Src homology 2 (SH2) and SH3 domains of p120GAP and Grb2.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(4):543-50.
1995: DH van Weering; J P Medema; AA van Puijenbroek; Boudewijn M T Burgering; P D Baas; Johannes L Bos
Ret receptor tyrosine kinase activates extracellular signal-regulated kinase 2 in SK-N-MC cells.
Oncogene 1995;11(11):2207-14.
1995: Johannes L Bos
A target for phosphoinositide 3-kinase: Akt/PKB.
Trends in biochemical sciences 1995;20(11):441-2.
1995: J P Medema; Alida M M de Vries-Smits; Johannes L Bos
Calcium induces tyrosine phosphorylation of a novel p120GAP-associated protein of 65 kDa.
Oncogene 1995;11(4):757-62.
1995: Paul J Coffer; Boudewijn M T Burgering; Maikel Peppelenbosch; Johannes L Bos; Wiebe Kruijer
UV activation of receptor tyrosine kinase activity.
Oncogene 1995;11(3):561-9.
1995: Johannes L Bos
p21ras: an oncoprotein functioning in growth factor-induced signal transduction.
European journal of cancer (Oxford, England : 1990) 1995;31A(7-8):1051-4.
1995: Maikel Peppelenbosch; R G Qiu; Alida M M de Vries-Smits; Leon Tertoolen; SW De Laat; F McCormick; Alan Hall; Marc Symons; Johannes L Bos
Rac mediates growth factor-induced arachidonic acid release.
Cell 1995;81(6):849-56.
1995: Alida M M de Vries-Smits; G J Pronk; J P Medema; Boudewijn M T Burgering; Johannes L Bos
Shc associates with an unphosphorylated form of the p21ras guanine nucleotide exchange factor mSOS.
Oncogene 1995;10(5):919-25.
1995: Alida M M de Vries-Smits; Boudewijn M T Burgering; Johannes L Bos
Vaccinia virus expression of p21 rasAsn-17.
Methods in enzymology 1995;255():221-9.
1995: Alida M M de Vries-Smits; Julian Downward; Johannes L Bos
Measurements of GTP/GDP exchange in permeabilized fibroblasts.
Methods in enzymology 1995;255():156-61.
1995: Boudewijn M T Burgering; Johannes L Bos
Regulation of Ras-mediated signalling: more than one way to skin a cat.
Trends in biochemical sciences 1995;20(1):18-22.
1994: G J Pronk; Johannes L Bos
The role of p21ras in receptor tyrosine kinase signalling.
Biochimica et biophysica acta 1994;1198(2-3):131-47.
1994: D M Ouwens; Gerard C M van der Zon; G J Pronk; Johannes L Bos; W Möller; B Cheatham; C R Kahn; J Antonie Maassen
A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation.
The Journal of biological chemistry 1994;269(52):33116-22.
1994: J P Medema; M W Sark; Claude Backendorf; Johannes L Bos
Calcium inhibits epidermal growth factor-induced activation of p21ras in human primary keratinocytes.
Molecular and cellular biology 1994;14(11):7078-85.
1994: G J Pronk; Alida M M de Vries-Smits; László Buday; Julian Downward; J Antonie Maassen; R H Medema; Johannes L Bos
Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras.
Molecular and cellular biology 1994;14(3):1575-81.
1994: Boudewijn M T Burgering; E Freed; L van der Voorn; F McCormick; Johannes L Bos
Platelet-derived growth factor-induced p21ras-mediated signaling is independent of platelet-derived growth factor receptor interaction with GTPase-activating protein or phosphatidylinositol-3-kinase.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(3):341-7.
1993: Boudewijn M T Burgering; Alida M M de Vries-Smits; R H Medema; P C van Weeren; Leon Tertoolen; Johannes L Bos
Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways.
Molecular and cellular biology 1993;13(12):7248-56.
1993: Boudewijn M T Burgering; G J Pronk; P C van Weeren; P Chardin; Johannes L Bos
cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor.
The EMBO journal 1993;12(11):4211-20.
1993: Boudewijn M T Burgering; G J Pronk; J P Medema; L van der Voorn; Alida M M de Vries-Smits; P C van Weeren; Johannes L Bos
Role of p21ras in growth factor signal transduction.
Biochemical Society transactions 1993;21(4):888-94.
1993: G J Pronk; Alida M M de Vries-Smits; C Ellis; Johannes L Bos
Complex formation between the p21ras GTPase-activating protein and phosphoproteins p62 and p190 is independent of p21ras signalling.
Oncogene 1993;8(10):2773-80.
1993: DH van Weering; P D Baas; Johannes L Bos
A PCR-based method for the analysis of human CD44 splice products.
PCR methods and applications 1993;3(2):100-6.
1993: G J Pronk; J McGlade; Giuliana Pelicci; Tony Pawson; Johannes L Bos
Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins.
The Journal of biological chemistry 1993;268(8):5748-53.
1993: A P Osterop; R H Medema; G C vd Zon; Johannes L Bos; W Möller; J Antonie Maassen
Epidermal-growth-factor receptors generate Ras.GTP more efficiently than insulin receptors.
European journal of biochemistry / FEBS 1993;212(2):477-82.
1993: R H Medema; Alida M M de Vries-Smits; Gerard C M van der Zon; J Antonie Maassen; Johannes L Bos
Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras.
Molecular and cellular biology 1993;13(1):155-62.
1993: R H Medema; Johannes L Bos
The role of p21ras in receptor tyrosine kinase signaling.
Critical reviews in oncogenesis 1993;4(6):615-61.
1992: G J Pronk; R H Medema; Boudewijn M T Burgering; R Clark; F McCormick; Johannes L Bos
Interaction between the p21ras GTPase activating protein and the insulin receptor.
The Journal of biological chemistry 1992;267(33):24058-63.
1992: R H Medema; W L de Laat; George Martin; F McCormick; Johannes L Bos
GTPase-activating protein SH2-SH3 domains induce gene expression in a Ras-dependent fashion.
Molecular and cellular biology 1992;12(8):3425-30.
1992: A P Osterop; R H Medema; Johannes L Bos; G C vd Zon; D E Moller; J S Flier; W Möller; J Antonie Maassen
Relation between the insulin receptor number in cells, autophosphorylation and insulin-stimulated Ras.GTP formation.
The Journal of biological chemistry 1992;267(21):14647-53.
1992: Alida M M de Vries-Smits; Boudewijn M T Burgering; S J Leevers; C J Marshall; Johannes L Bos
Involvement of p21ras in activation of extracellular signal-regulated kinase 2.
Nature 1992;357(6379):602-4.
1992: Johannes L Bos; A D Van Mansfeld
Detection of point mutations in p21ras genes.
Annals of medicine 1992;24(3):207-9.
1992: J Antonie Maassen; Boudewijn M T Burgering; R H Medema; A P Osterop; Gerard C M van der Zon; W Möller; Johannes L Bos
The role of ras proteins in insulin signal transduction.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1992;24(5):214-8.
1992: A D van Mansfeld; Johannes L Bos
PCR-based approaches for detection of mutated ras genes.
PCR methods and applications 1992;1(4):211-6.
1992: G J Pronk; P Polakis; G Wong; Alida M M de Vries-Smits; Johannes L Bos; F McCormick
Association of a tyrosine kinase activity with GAP complexes in v-src transformed fibroblasts.
Oncogene 1992;7(2):389-94.
1992: Johannes L Bos; Coen F van Kreijl
Genes and gene products that regulate proliferation and differentiation: critical targets in carcinogenesis.
IARC scientific publications 1992;(116):57-65.
1991: R H Medema; R Wubbolts; Johannes L Bos
Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression.
Molecular and cellular biology 1991;11(12):5963-7.
1991: R H Medema; Boudewijn M T Burgering; Johannes L Bos
Insulin-induced p21ras activation does not require protein kinase C, but a protein sensitive to phenylarsine oxide.
The Journal of biological chemistry 1991;266(31):21186-9.
1991: I Meijer; Hans van Dam; A J Boot; Johannes L Bos; Alt Zantema; Alex J van der Eb
Co-regulated expression of junB and MHC class I genes in adenovirus-transformed cells.
Oncogene 1991;6(6):911-6.
1991: Boudewijn M T Burgering; R H Medema; J Antonie Maassen; Marc van de Wetering; Alex J van der Eb; F McCormick; Johannes L Bos
Insulin stimulation of gene expression mediated by p21ras activation.
The EMBO journal 1991;10(5):1103-9.
1990: Hans van Dam; Rienk Offringa; I Meijer; B Stein; A M Smits; Peter Herrlich; Johannes L Bos; Alex J van der Eb
Differential effects of the adenovirus E1A oncogene on members of the AP-1 transcription factor family.
Molecular and cellular biology 1990;10(11):5857-64.
1990: Rienk Offringa; S Gebel; Hans van Dam; MC Timmers; A Smits; R Zwart; B Stein; Johannes L Bos; Alex J van der Eb; Peter Herrlich
A novel function of the transforming domain of E1a: repression of AP-1 activity.
Cell 1990;62(3):527-38.
1990: H T Timmers; G J Pronk; Johannes L Bos; Alex J van der Eb
Analysis of the rat JE gene promoter identifies an AP-1 binding site essential for basal expression but not for TPA induction.
Nucleic acids research 1990;18(1):23-34.
1989: Boudewijn M T Burgering; A J Snijders; J Antonie Maassen; Alex J van der Eb; Johannes L Bos
Possible involvement of normal p21 H-ras in the insulin/insulinlike growth factor 1 signal transduction pathway.
Molecular and cellular biology 1989;9(10):4312-22.
1989: Hans van Dam; Rienk Offringa; A M Smits; Johannes L Bos; N C Jones; Alex J van der Eb
The repression of the growth factor-inducible genes JE, c-myc and stromelysin by adenovirus E1A is mediated by conserved region 1.
Oncogene 1989;4(10):1207-12.
1989: I Meijer; Aart G Jochemsen; C M de Wit; Johannes L Bos; D Morello; Alex J van der Eb
Adenovirus type 12 E1A down regulates expression of a transgene under control of a major histocompatibility complex class I promoter: evidence for transcriptional control.
Journal of virology 1989;63(9):4039-42.
1989: L J van 't Veer; Boudewijn M T Burgering; R Versteeg; A J Boot; D J Ruiter; Susanne Osanto; Peter I Schrier; Johannes L Bos
N-ras mutations in human cutaneous melanoma from sun-exposed body sites.
Molecular and cellular biology 1989;9(7):3114-6.
1989: H T Timmers; Hans van Dam; G J Pronk; Johannes L Bos; Alex J van der Eb
Adenovirus E1A represses transcription of the cellular JE gene.
Journal of virology 1989;63(3):1470-3.
1988: Rienk Offringa; A M Smits; A Houweling; Johannes L Bos; Alex J van der Eb
Similar effects of adenovirus E1A and glucocorticoid hormones on the expression of the metalloprotease stromelysin.
Nucleic acids research 1988;16(23):10973-84.
1988: Vincent T H B M Smit; A J Boot; A M Smits; Gert Jan Fleuren; Cees J Cornelisse; Johannes L Bos
KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas.
Nucleic acids research 1988;16(16):7773-82.
1988: Johannes L Bos
The ras gene family and human carcinogenesis.
Mutation research 1988;195(3):255-71.
1988: L J van 't Veer; R Hermens; L A van den Berg-Bakker; N C Cheng; G J Fleuren; Johannes L Bos; F J Cleton; Peter I Schrier
ras oncogene activation in human ovarian carcinoma.
Oncogene 1988;2(2):157-65.
1988: H T Timmers; E J van Zoelen; Johannes L Bos; Alex J van der Eb
Cells transformed by adenovirus type 12 but not by type 5 are dependent on insulin or insulin-like growth factor I for their proliferation.
The Journal of biological chemistry 1988;263(3):1329-35.
1988: J L Van der Lubbe; H J Rosdorff; Johannes L Bos; Alex J van der Eb
Activation of N-ras induced by ultraviolet irradiation in vitro.
Oncogene research 1988;3(1):9-20.
1988: H T Timmers; D De Wit; Johannes L Bos; Alex J van der Eb
E1A products of adenoviruses reduce the expression of cellular proliferation-associated genes.
Oncogene research 1988;3(1):67-76.
1987: Aart G Jochemsen; Lucy T C Peltenburg; M F te Pas; C M de Wit; Johannes L Bos; Alex J van der Eb
Activation of adenovirus 5 E1A transcription by region E1B in transformed primary rat cells.
The EMBO journal 1987;6(11):3399-405.
1986: Aart G Jochemsen; C M de Wit; Johannes L Bos; Alex J van der Eb
Transforming properties of a 15-kDa truncated Ad12 E1A gene product.
Virology 1986;152(2):375-83.
1983: Johannes L Bos; H C ten Wolde-Kraamwinkel
The E1b promoter of Ad12 in mouse L tk- cells is activated by adenovirus region E1a.
The EMBO journal 1983;2(1):73-6.