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Johannes Bos

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
28
Burgering, Boudewijn
21
Zwartkruis, Fried
19
Rehmann, Holger
17
de Rooij, Johan
17
de Vries-Smits, Alida
15
van der Eb, Alex
13
Wittinghofer, Alfred
13
Wolthuis, RM
11
Maassen, Antonie
9
Reedquist, Kris
8
van Triest, Miranda
8
Cool, Robbert
7
van Weering, DH
7
van Dam, Hans
7
Schwede, Frank

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Publications

TOP 3
van Dam Teunis J P; Rehmann Holger; Bos Johannes L; Snel Berend
Phylogeny of the CDC25 homology domain reveals rapid differentiation of Ras pathways between early animals and fungi.
Ponsioen Bas; Gloerich Martijn; Ritsma Laila; Rehmann Holger; Bos Johannes L; Jalink Kees
Direct spatial control of Epac1 by cyclic AMP.
Pannekoek Willem-Jan; Kooistra Matthijs R H; Zwartkruis Fried J T; Bos Johannes L
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.

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All Publications

2009: van Dam Teunis J P; Rehmann Holger; Bos Johannes L; Snel Berend
Phylogeny of the CDC25 homology domain reveals rapid differentiation of Ras pathways between early animals and fungi.
Cellular signalling 2009;21(11):1579-85.
2009: Ponsioen Bas; Gloerich Martijn; Ritsma Laila; Rehmann Holger; Bos Johannes L; Jalink Kees
Direct spatial control of Epac1 by cyclic AMP.
Molecular and cellular biology 2009;29(10):2521-31.
2009: Pannekoek Willem-Jan; Kooistra Matthijs R H; Zwartkruis Fried J T; Bos Johannes L
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
Biochimica et biophysica acta 2009;1788(4):790-6.
2009: Raaijmakers Judith H; Bos Johannes L
Specificity in Ras and Rap signaling.
The Journal of biological chemistry 2009;284(17):10995-9.
2008: Lorenowicz Magdalena J; Fernandez-Borja Mar; Kooistra Matthijs R H; Bos Johannes L; Hordijk Peter L
PKA and Epac1 regulate endothelial integrity and migration through parallel and independent pathways.
European journal of cell biology 2008;87(10):779-92.
2008: Rehmann Holger; Arias-Palomo Ernesto; Hadders Michael A; Schwede Frank; Llorca Oscar; Bos Johannes L
Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B.
Nature 2008;455(7209):124-7.
2008: Vliem Marjolein J; Ponsioen Bas; Schwede Frank; Pannekoek Willem-Jan; Riedl Jurgen; Kooistra Matthijs R H; Jalink Kees; Genieser Hans-Gottfried; Bos Johannes L; Rehmann Holger
8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue.
Chembiochem : a European journal of chemical biology 2008;9(13):2052-4.
2008: Dubé Nadia; Kooistra Matthijs R H; Pannekoek Willem-Jan; Vliem Marjolein J; Oorschot Viola; Klumperman Judith; Rehmann Holger; Bos Johannes L
The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctions.
Cellular signalling 2008;20(9):1608-15.
2008: Lyle Karen S; Raaijmakers Judith H; Bruinsma Wytse; Bos Johannes L; de Rooij Johan
cAMP-induced Epac-Rap activation inhibits epithelial cell migration by modulating focal adhesion and leading edge dynamics.
Cellular signalling 2008;20(6):1104-16.
2008: Poppe Heiko; Rybalkin Sergei D; Rehmann Holger; Hinds Thomas R; Tang Xiao-Bo; Christensen Anne E; Schwede Frank; Genieser Hans-Gottfried; Bos Johannes L; Doskeland Stein O; Beavo Joseph A; Butt Elke
Cyclic nucleotide analogs as probes of signaling pathways.
Nature methods 2008;5(4):277-8.
2008: Harper Shannon M; Wienk Hans; Wechselberger Rainer W; Bos Johannes L; Boelens Rolf; Rehmann Holger
Structural dynamics in the activation of Epac.
The Journal of biological chemistry 2008;283(10):6501-8.
2007: Frische Ester W; Pellis-van Berkel Wendy; van Haaften Gijs; Cuppen Edwin; Plasterk Ronald H A; Tijsterman Marcel; Bos Johannes L; Zwartkruis Fried J T
RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans.
The EMBO journal 2007;26(24):5083-92.
2007: Bos Johannes L; Rehmann Holger; Wittinghofer Alfred
GEFs and GAPs: critical elements in the control of small G proteins.
Cell 2007;129(5):865-77.
2007: Raaijmakers Judith H; Deneubourg Laurence; Rehmann Holger; de Koning John; Zhang Zhongchun; Krugmann Sonja; Erneux Christophe; Bos Johannes L
The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner.
Cellular signalling 2007;19(6):1249-57.
2007: Rehmann Holger; Wittinghofer Alfred; Bos Johannes L
Capturing cyclic nucleotides in action: snapshots from crystallographic studies.
Nature reviews. Molecular cell biology 2007;8(1):63-73.
2007: Kooistra Matthijs R H; Dubé Nadia; Bos Johannes L
Rap1: a key regulator in cell-cell junction formation.
Journal of cell science 2007;120(Pt 1):17-22.
2006: Bos Johannes L
Epac proteins: multi-purpose cAMP targets.
Trends in biochemical sciences 2006;31(12):680-6.
2006: Kang Guoxin; Chepurny Oleg G; Malester Brian; Rindler Michael J; Rehmann Holger; Bos Johannes L; Schwede Frank; Coetzee William A; Holz George G
cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells.
The Journal of physiology 2006;573(Pt 3):595-609.
2006: Rehmann Holger; Das Joost; Knipscheer Puck; Wittinghofer Alfred; Bos Johannes L
Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state.
Nature 2006;439(7076):625-8.
2006: Roccio M; Bos J L; Zwartkruis F J T
Regulation of the small GTPase Rheb by amino acids.
Oncogene 2006;25(5):657-64.
2005: Nobukuni Takahiro; Joaquin Manel; Roccio Marta; Dann Stephen G; Kim So Young; Gulati Pawan; Byfield Maya P; Backer Jonathan M; Natt Francois; Bos Johannes L; Zwartkruis Fried J T; Thomas George
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(40):14238-43.
2005: Kooistra Matthijs R H; Corada Monica; Dejana Elisabetta; Bos Johannes L
Epac1 regulates integrity of endothelial cell junctions through VE-cadherin.
FEBS letters 2005;579(22):4966-72.
2005: Zhang Zhongchun; Rehmann Holger; Price Leo S; Riedl Jurgen; Bos Johannes L
AF6 negatively regulates Rap1-induced cell adhesion.
The Journal of biological chemistry 2005;280(39):33200-5.
2005: Riedl Jurgen A; Brandt Dominique T; Batlle Eduard; Price Leo S; Clevers Hans; Bos Johannes L
Down-regulation of Rap1 activity is involved in ephrinB1-induced cell contraction.
The Biochemical journal 2005;389(Pt 2):465-9.
2005: Bos Johannes L
Linking Rap to cell adhesion.
Current opinion in cell biology 2005;17(2):123-8.
2005: Kuiperij H Bea; van der Horst Armando; Raaijmakers Judith; Weijzen Sanne; Medema Rene H; Bos Johannes L; Burgering Boudewijn M T; Zwartkruis Fried J T
Activation of FoxO transcription factors contributes to the antiproliferative effect of cAMP.
Oncogene 2005;24(12):2087-95.
2005: Pellis-van Berkel W; Verheijen M H G; Cuppen E; Asahina M; de Rooij J; Jansen G; Plasterk R H A; Bos J L; Zwartkruis F J T
Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity.
Molecular biology of the cell 2005;16(1):106-16.
2004: Ponsioen Bas; Zhao Jun; Riedl Jurgen; Zwartkruis Fried; van der Krogt Gerard; Zaccolo Manuela; Moolenaar Wouter H; Bos Johannes L; Jalink Kees
Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator.
EMBO reports 2004;5(12):1176-80.
2004: Essers Marieke A G; Weijzen Sanne; de Vries-Smits Alida M M; Saarloos Ingrid; de Ruiter Nancy D; Bos Johannes L; Burgering Boudewijn M T
FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.
The EMBO journal 2004;23(24):4802-12.
2004: Price Leo S; Bos Johannes L
RAPL: taking the Rap in immunity.
Nature immunology 2004;5(10):1007-8.
2004: Enserink Jorrit M; Price Leo S; Methi Trond; Mahic Milada; Sonnenberg Arnoud; Bos Johannes L; Taskén Kjetil
The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin.
The Journal of biological chemistry 2004;279(43):44889-96.
2004: Bos Johannes L; Burgering Boudewijn M T
Molecular mechanisms in signal transduction and cancer.
EMBO reports 2004;5(9):855-9.
2004: Price Leo S; Hajdo-Milasinovic Amra; Zhao Jun; Zwartkruis Fried J T; Collard John G; Bos Johannes L
Rap1 regulates E-cadherin-mediated cell-cell adhesion.
The Journal of biological chemistry 2004;279(34):35127-32.
2004: Remans Philip H J; Gringhuis Sonja I; van Laar Jacob M; Sanders Marjolein E; Papendrecht-van der Voort Ellen A M; Zwartkruis Fried J T; Levarht E W Nivine; Rosas Marcela; Coffer Paul J; Breedveld Ferdinand C; Bos Johannes L; Tak Paul P; Verweij Cornelis L; Reedquist Kris A
Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):920-31.
2004: Rehmann Holger; Bos Johannes L
Signal transduction: thumbs up for inactivation.
Nature 2004;429(6988):138-9.
2004: Dansen Tobias B; Kops Geert J P L; Denis Simone; Jelluma Nannette; Wanders Ronald J A; Bos Johannes L; Burgering Boudewijn M T; Wirtz Karel W A
Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3a.
Journal of lipid research 2004;45(1):81-8.
2004: van Triest Miranda; Bos Johannes L
Pull-down assays for guanoside 5'-triphosphate-bound Ras-like guanosine 5'-triphosphatases.
Methods in molecular biology (Clifton, N.J.) 2004;250():97-102.
2003: Rehmann Holger; Schwede Frank; Døskeland Stein O; Wittinghofer Alfred; Bos Johannes L
Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac.
The Journal of biological chemistry 2003;278(40):38548-56.
2003: Bos Johannes L
Epac: a new cAMP target and new avenues in cAMP research.
Nature reviews. Molecular cell biology 2003;4(9):733-8.
2003: Christensen Anne E; Selheim Frode; de Rooij Johan; Dremier Sarah; Schwede Frank; Dao Khanh K; Martinez Aurora; Maenhaut Carine; Bos Johannes L; Genieser H-G; Døskeland Stein O
cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension.
The Journal of biological chemistry 2003;278(37):35394-402.
2003: Garami Attila; Zwartkruis Fried J T; Nobukuni Takahiro; Joaquin Manel; Roccio Marta; Stocker Hugo; Kozma Sara C; Hafen Ernst; Bos Johannes L; Thomas George
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.
Molecular cell 2003;11(6):1457-66.
2003: Rehmann Holger; Rueppel Alma; Bos Johannes L; Wittinghofer Alfred
Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac.
The Journal of biological chemistry 2003;278(26):23508-14.
2003: de Bruyn Kim M T; Zwartkruis Fried J T; de Rooij Johan; Akkerman Jan-Willem N; Bos Johannes L
The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes.
The Journal of biological chemistry 2003;278(25):22412-7.
2003: Kang Guoxin; Joseph Jamie W; Chepurny Oleg G; Monaco Marie; Wheeler Michael B; Bos Johannes L; Schwede Frank; Genieser Hans-G; Holz George G
Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.
The Journal of biological chemistry 2003;278(10):8279-85.
2003: Kuiperij H Bea; de Rooij Johan; Rehmann Holger; van Triest Miranda; Wittinghofer Alfred; Bos Johannes L; Zwartkruis Fried J T
Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2.
Biochimica et biophysica acta 2003;1593(2-3):141-9.
2003: Rangarajan Savithri; Enserink Jorrit M; Kuiperij H Bea; de Rooij Johan; Price Leo S; Schwede Frank; Bos Johannes L
Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor.
The Journal of cell biology 2003;160(4):487-93.
2003: Bos J L; de Bruyn K; Enserink J; Kuiperij B; Rangarajan S; Rehmann H; Riedl J; de Rooij J; van Mansfeld F; Zwartkruis F
The role of Rap1 in integrin-mediated cell adhesion.
Biochemical Society transactions 2003;31(Pt 1):83-6.
2003: Rehmann Holger; Prakash Balaji; Wolf Eva; Rueppel Alma; de Rooij Johan; Bos Johannes L; Wittinghofer Alfred
Structure and regulation of the cAMP-binding domains of Epac2.
Nature structural biology 2003;10(1):26-32.
2002: Enserink Jorrit M; Christensen Anne E; de Rooij Johan; van Triest Miranda; Schwede Frank; Genieser Hans Gottfried; Døskeland Stein O; Blank Jonathan L; Bos Johannes L
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.
Nature cell biology 2002;4(11):901-6.
2002: Kops Geert J P L; Dansen Tobias B; Polderman Paulien E; Saarloos Ingrid; Wirtz Karel W A; Coffer Paul J; Huang Ting-T; Bos Johannes L; Medema René H; Burgering Boudewijn M T
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress.
Nature 2002;419(6904):316-21.
2002: de Bruyn Kim M T; Rangarajan Savithri; Reedquist Kris A; Figdor Carl G; Bos Johannes L
The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion.
The Journal of biological chemistry 2002;277(33):29468-76.
2002: Ouwens D Margriet; de Ruiter Nancy D; van der Zon Gerard C M; Carter Andrew P; Schouten Jan; van der Burgt Corina; Kooistra Klaas; Bos Johannes L; Maassen J Antonie; van Dam Hans
Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38.
The EMBO journal 2002;21(14):3782-93.
2001: De Ruiter N D; Burgering B M; Bos J L
Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451.
Molecular and cellular biology 2001;21(23):8225-35.
2001: Bos J L; de Rooij J; Reedquist K A
Rap1 signalling: adhering to new models.
Nature reviews. Molecular cell biology 2001;2(5):369-77.
2001: Kraemer A; Rehmann H R; Cool R H; Theiss C; de Rooij J; Bos J L; Wittinghofer A
Dynamic interaction of cAMP with the Rap guanine-nucleotide exchange factor Epac1.
Journal of molecular biology 2001;306(5):1167-77.
2001: van Triest M; de Rooij J; Bos J L
Measurement of GTP-bound Ras-like GTPases by activation-specific probes.
Methods in enzymology 2001;333():343-8.
2000: de Ruiter N D; Wolthuis R M; van Dam H; Burgering B M; Bos J L
Ras-dependent regulation of c-Jun phosphorylation is mediated by the Ral guanine nucleotide exchange factor-Ral pathway.
Molecular and cellular biology 2000;20(22):8480-8.
2000: Amsen D; Kruisbeek A; Bos J L; Reedquist K
Activation of the Ras-related GTPase Rap1 by thymocyte TCR engagement and during selection.
European journal of immunology 2000;30(10):2832-41.
2000: Lu L; Annerén C; Reedquist K A; Bos J L; Welsh M
NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway.
Experimental cell research 2000;259(2):370-7.
2000: de Bruyn K M; de Rooij J; Wolthuis R M; Rehmann H; Wesenbeek J; Cool R H; Wittinghofer A H; Bos J L
RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral.
The Journal of biological chemistry 2000;275(38):29761-6.
2000: Annerén C; Reedquist K A; Bos J L; Welsh M
GTK, a Src-related tyrosine kinase, induces nerve growth factor-independent neurite outgrowth in PC12 cells through activation of the Rap1 pathway. Relationship to Shb tyrosine phosphorylation and elevated levels of focal adhesion kinase.
The Journal of biological chemistry 2000;275(37):29153-61.
2000: Hackeng C M; Franke B; Relou I A; Gorter G; Bos J L; van Rijn H J; Akkerman J W
Low-density lipoprotein activates the small GTPases Rap1 and Ral in human platelets.
The Biochemical journal 2000;349(Pt 1):231-8.
2000: de Rooij J; Rehmann H; van Triest M; Cool R H; Wittinghofer A; Bos J L
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.
The Journal of biological chemistry 2000;275(27):20829-36.
2000: Medema R H; Kops G J; Bos J L; Burgering B M
AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1.
Nature 2000;404(6779):782-7.
2000: Reedquist K A; Ross E; Koop E A; Wolthuis R M; Zwartkruis F J; van Kooyk Y; Salmon M; Buckley C D; Bos J L
The small GTPase, Rap1, mediates CD31-induced integrin adhesion.
The Journal of cell biology 2000;148(6):1151-8.
2000: Franke B; van Triest M; de Bruijn K M; van Willigen G; Nieuwenhuis H K; Negrier C; Akkerman J W; Bos J L
Sequential regulation of the small GTPase Rap1 in human platelets.
Molecular and cellular biology 2000;20(3):779-85.
2000: Dremier S; Vandeput F; Zwartkruis F J; Bos J L; Dumont J E; Maenhaut C
Activation of the small G protein Rap1 in dog thyroid cells by both cAMP-dependent and -independent pathways.
Biochemical and biophysical research communications 2000;267(1):7-11.
1999: de Rooij J; Boenink N M; van Triest M; Cool R H; Wittinghofer A; Bos J L
PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2.
The Journal of biological chemistry 1999;274(53):38125-30.
1999: Zwartkruis F J; Bos J L
Ras and Rap1: two highly related small GTPases with distinct function.
Experimental cell research 1999;253(1):157-65.
1999: Spaargaren M; Bos J L
Rab5 induces Rac-independent lamellipodia formation and cell migration.
Molecular biology of the cell 1999;10(10):3239-50.
1999: Steegenga W T; Riteco N; Bos J L
Infectivity and expression of the early adenovirus proteins are important regulators of wild-type and DeltaE1B adenovirus replication in human cells.
Oncogene 1999;18(36):5032-43.
1999: Verheijen M H; Wolthuis R M; Defize L H; den Hertog J; Bos J L
Interdependent action of RalGEF and Erk in Ras-induced primitive endoderm differentiation of F9 embryonal carcinoma cells.
Oncogene 1999;18(31):4435-9.
1999: M'Rabet L; Coffer P J; Wolthuis R M; Zwartkruis F; Koenderman L; Bos J L
Differential fMet-Leu-Phe- and platelet-activating factor-induced signaling toward Ral activation in primary human neutrophils.
The Journal of biological chemistry 1999;274(31):21847-52.
1999: Steegenga W T; Shvarts A; Riteco N; Bos J L; Jochemsen A G
Distinct regulation of p53 and p73 activity by adenovirus E1A, E1B, and E4orf6 proteins.
Molecular and cellular biology 1999;19(5):3885-94.
1999: Kops G J; de Ruiter N D; De Vries-Smits A M; Powell D R; Bos J L; Burgering B M
Direct control of the Forkhead transcription factor AFX by protein kinase B.
Nature 1999;398(6728):630-4.
1999: Nancy V; Wolthuis R M; de Tand M F; Janoueix-Lerosey I; Bos J L; de Gunzburg J
Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2.
The Journal of biological chemistry 1999;274(13):8737-45.
1999: Wolthuis R M; Bos J L
Ras caught in another affair: the exchange factors for Ral.
Current opinion in genetics & development 1999;9(1):112-7.
1999: Verheijen M H; Wolthuis R M; Bos J L; Defize L H
The Ras/Erk pathway induces primitive endoderm but prevents parietal endoderm differentiation of F9 embryonal carcinoma cells.
The Journal of biological chemistry 1999;274(3):1487-94.
1998: de Rooij J; Zwartkruis F J; Verheijen M H; Cool R H; Nijman S M; Wittinghofer A; Bos J L
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.
Nature 1998;396(6710):474-7.
1998: Bos J L
All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral.
The EMBO journal 1998;17(23):6776-82.
1998: Zwartkruis F J; Wolthuis R M; Nabben N M; Franke B; Bos J L
Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling.
The EMBO journal 1998;17(20):5905-12.
1998: M'Rabet L; Coffer P; Zwartkruis F; Franke B; Segal A W; Koenderman L; Bos J L
Activation of the small GTPase rap1 in human neutrophils.
Blood 1998;92(6):2133-40.
1998: Aarts L H; Schrama L H; Hage W J; Bos J L; Gispen W H; Schotman P
B-50/GAP-43-induced formation of filopodia depends on Rho-GTPase.
Molecular biology of the cell 1998;9(6):1279-92.
1998: van Weering D H; Moen T C; Braakman I; Baas P D; Bos J L
Expression of the receptor tyrosine kinase Ret on the plasma membrane is dependent on calcium.
The Journal of biological chemistry 1998;273(20):12077-81.
1998: Wolthuis R M; Franke B; van Triest M; Bauer B; Cool R H; Camonis J H; Akkerman J W; Bos J L
Activation of the small GTPase Ral in platelets.
Molecular and cellular biology 1998;18(5):2486-91.
1998: Wolthuis R M; Zwartkruis F; Moen T C; Bos J L
Ras-dependent activation of the small GTPase Ral.
Current biology : CB 1998;8(8):471-4.
1998: van Weering D H; de Rooij J; Marte B; Downward J; Bos J L; Burgering B M
Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras.
Molecular and cellular biology 1998;18(4):1802-11.
1998: Reedquist K A; Bos J L
Costimulation through CD28 suppresses T cell receptor-dependent activation of the Ras-like small GTPase Rap1 in human T lymphocytes.
The Journal of biological chemistry 1998;273(9):4944-9.
1998: Steegenga W T; Riteco N; Jochemsen A G; Fallaux F J; Bos J L
The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells.
Oncogene 1998;16(3):349-57.
1998: van Weering D H; Bos J L
Signal transduction by the receptor tyrosine kinase Ret.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1998;154():271-81.
1997: Coffer P J; van Puijenbroek A; Burgering B M; Klop-de Jonge M; Koenderman L; Bos J L; Kruijer W
Insulin activates Stat3 independently of p21ras-ERK and PI-3K signal transduction.
Oncogene 1997;15(21):2529-39.
1997: Wolthuis R M; de Ruiter N D; Cool R H; Bos J L
Stimulation of gene induction and cell growth by the Ras effector Rlf.
The EMBO journal 1997;16(22):6748-61.
1997: Bos J L
Ras-like GTPases.
Biochimica et biophysica acta 1997;1333(2):M19-31.
1997: Bos J L; Franke B; M'Rabet L; Reedquist K; Zwartkruis F
In search of a function for the Ras-like GTPase Rap1.
FEBS letters 1997;410(1):59-62.
1997: van Puijenbroek A A; van Weering D H; van den Brink C E; Bos J L; van der Saag P T; de Laat S W; den Hertog J
Cell scattering of SK-N-MC neuroepithelioma cells in response to Ret and FGF receptor tyrosine kinase activation is correlated with sustained ERK2 activation.
Oncogene 1997;14(10):1147-57.
1997: de Rooij J; Bos J L
Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras.
Oncogene 1997;14(5):623-5.
1997: Franke B; Akkerman J W; Bos J L
Rapid Ca2+-mediated activation of Rap1 in human platelets.
The EMBO journal 1997;16(2):252-9.
1997: van Weering D H; Bos J L
Glial cell line-derived neurotrophic factor induces Ret-mediated lamellipodia formation.
The Journal of biological chemistry 1997;272(1):249-54.
1997: Dorrestijn J; Bos J L; Van der Zon G C; Maassen J A
Changes in the signalling status of the small GTP-binding proteins Rac and Rho do not influence insulin-stimulated hexose transport.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1997;105(5):254-62.
1996: Wolthuis R M; Bauer B; van 't Veer L J; de Vries-Smits A M; Cool R H; Spaargaren M; Wittinghofer A; Burgering B M; Bos J L
RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein.
Oncogene 1996;13(2):353-62.
1996: Dorrestijn J; Ouwens D M; Van den Berghe N; Bos J L; Maassen J A
Expression of a dominant-negative Ras mutant does not affect stimulation of glucose uptake and glycogen synthesis by insulin.
Diabetologia 1996;39(5):558-63.
1996: Medema J P; Pronk G J; de Vries-Smits A M; Clark R; McCormick F; Bos J L
Insulin-induced tyrosine phosphorylation of a M(r) 70,000 protein revealed by association with the Src homology 2 (SH2) and SH3 domains of p120GAP and Grb2.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(4):543-50.
1996: Peppelenbosch M P; Tertoolen L G; de Vries-Smits A M; Qiu R G; M'Rabet L; Symons M H; de Laat S W; Bos J L
Rac-dependent and -independent pathways mediate growth factor-induced Ca2+ influx.
The Journal of biological chemistry 1996;271(14):7883-6.
1995: van Weering D H; Medema J P; van Puijenbroek A; Burgering B M; Baas P D; Bos J L
Ret receptor tyrosine kinase activates extracellular signal-regulated kinase 2 in SK-N-MC cells.
Oncogene 1995;11(11):2207-14.
1995: Bos J L
A target for phosphoinositide 3-kinase: Akt/PKB.
Trends in biochemical sciences 1995;20(11):441-2.
1995: Medema J P; de Vries-Smits A M; Bos J L
Calcium induces tyrosine phosphorylation of a novel p120GAP-associated protein of 65 kDa.
Oncogene 1995;11(4):757-62.
1995: Coffer P J; Burgering B M; Peppelenbosch M P; Bos J L; Kruijer W
UV activation of receptor tyrosine kinase activity.
Oncogene 1995;11(3):561-9.
1995: Bos J L
p21ras: an oncoprotein functioning in growth factor-induced signal transduction.
European journal of cancer (Oxford, England : 1990) 1995;31A(7-8):1051-4.
1995: Peppelenbosch M P; Qiu R G; de Vries-Smits A M; Tertoolen L G; de Laat S W; McCormick F; Hall A; Symons M H; Bos J L
Rac mediates growth factor-induced arachidonic acid release.
Cell 1995;81(6):849-56.
1995: de Vries-Smits A M; Pronk G J; Medema J P; Burgering B M; Bos J L
Shc associates with an unphosphorylated form of the p21ras guanine nucleotide exchange factor mSOS.
Oncogene 1995;10(5):919-25.
1995: Burgering B M; Bos J L
Regulation of Ras-mediated signalling: more than one way to skin a cat.
Trends in biochemical sciences 1995;20(1):18-22.
1995: de Vries-Smits A M; Burgering B M; Bos J L
Vaccinia virus expression of p21 rasAsn-17.
Methods in enzymology 1995;255():221-9.
1995: de Vries-Smits A M; van der Voorn; Downward J; Bos J L
Measurements of GTP/GDP exchange in permeabilized fibroblasts.
Methods in enzymology 1995;255():156-61.
1994: Pronk G J; Bos J L
The role of p21ras in receptor tyrosine kinase signalling.
Biochimica et biophysica acta 1994;1198(2-3):131-47.
1994: Ouwens D M; van der Zon G C; Pronk G J; Bos J L; Möller W; Cheatham B; Kahn C R; Maassen J A
A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation.
The Journal of biological chemistry 1994;269(52):33116-22.
1994: Medema J P; Sark M W; Backendorf C; Bos J L
Calcium inhibits epidermal growth factor-induced activation of p21ras in human primary keratinocytes.
Molecular and cellular biology 1994;14(11):7078-85.
1994: Pronk G J; de Vries-Smits A M; Buday L; Downward J; Maassen J A; Medema R H; Bos J L
Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras.
Molecular and cellular biology 1994;14(3):1575-81.
1994: Burgering B M; Freed E; van der Voorn L; McCormick F; Bos J L
Platelet-derived growth factor-induced p21ras-mediated signaling is independent of platelet-derived growth factor receptor interaction with GTPase-activating protein or phosphatidylinositol-3-kinase.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(3):341-7.
1993: Burgering B M; de Vries-Smits A M; Medema R H; van Weeren P C; Tertoolen L G; Bos J L
Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways.
Molecular and cellular biology 1993;13(12):7248-56.
1993: Burgering B M; Pronk G J; van Weeren P C; Chardin P; Bos J L
cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor.
The EMBO journal 1993;12(11):4211-20.
1993: Burgering B M; Pronk G J; Medema J P; van der Voorn L; de Vries Smits A M; van Weeren P C; Bos J L
Role of p21ras in growth factor signal transduction.
Biochemical Society transactions 1993;21(4):888-94.
1993: Pronk G J; de Vries-Smits A M; Ellis C; Bos J L
Complex formation between the p21ras GTPase-activating protein and phosphoproteins p62 and p190 is independent of p21ras signalling.
Oncogene 1993;8(10):2773-80.
1993: van Weering D H; Baas P D; Bos J L
A PCR-based method for the analysis of human CD44 splice products.
PCR methods and applications 1993;3(2):100-6.
1993: Pronk G J; McGlade J; Pelicci G; Pawson T; Bos J L
Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins.
The Journal of biological chemistry 1993;268(8):5748-53.
1993: Osterop A P; Medema R H; vd Zon G C; Bos J L; Möller W; Maassen J A
Epidermal-growth-factor receptors generate Ras.GTP more efficiently than insulin receptors.
European journal of biochemistry / FEBS 1993;212(2):477-82.
1993: Medema R H; de Vries-Smits A M; van der Zon G C; Maassen J A; Bos J L
Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras.
Molecular and cellular biology 1993;13(1):155-62.
1993: Medema R H; Bos J L
The role of p21ras in receptor tyrosine kinase signaling.
Critical reviews in oncogenesis 1993;4(6):615-61.
1992: Pronk G J; Medema R H; Burgering B M; Clark R; McCormick F; Bos J L
Interaction between the p21ras GTPase activating protein and the insulin receptor.
The Journal of biological chemistry 1992;267(33):24058-63.
1992: Medema R H; de Laat W L; Martin G A; McCormick F; Bos J L
GTPase-activating protein SH2-SH3 domains induce gene expression in a Ras-dependent fashion.
Molecular and cellular biology 1992;12(8):3425-30.
1992: Osterop A P; Medema R H; Bos J L; vd Zon G C; Moller D E; Flier J S; Möller W; Maassen J A
Relation between the insulin receptor number in cells, autophosphorylation and insulin-stimulated Ras.GTP formation.
The Journal of biological chemistry 1992;267(21):14647-53.
1992: de Vries-Smits A M; Burgering B M; Leevers S J; Marshall C J; Bos J L
Involvement of p21ras in activation of extracellular signal-regulated kinase 2.
Nature 1992;357(6379):602-4.
1992: Bos J L; Van Mansfeld A D
Detection of point mutations in p21ras genes.
Annals of medicine 1992;24(3):207-9.
1992: Maassen J A; Burgering B M; Medema R H; Osterop A P; van der Zon G C; Möller W; Bos J L
The role of ras proteins in insulin signal transduction.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1992;24(5):214-8.
1992: van Mansfeld A D; Bos J L
PCR-based approaches for detection of mutated ras genes.
PCR methods and applications 1992;1(4):211-6.
1992: Pronk G J; Polakis P; Wong G; de Vries-Smits A M; Bos J L; McCormick F
Association of a tyrosine kinase activity with GAP complexes in v-src transformed fibroblasts.
Oncogene 1992;7(2):389-94.
1992: Bos J L; van Kreijl C F
Genes and gene products that regulate proliferation and differentiation: critical targets in carcinogenesis.
IARC scientific publications 1992;(116):57-65.
1991: Medema R H; Wubbolts R; Bos J L
Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression.
Molecular and cellular biology 1991;11(12):5963-7.
1991: Medema R H; Burgering B M; Bos J L
Insulin-induced p21ras activation does not require protein kinase C, but a protein sensitive to phenylarsine oxide.
The Journal of biological chemistry 1991;266(31):21186-9.
1991: Meijer I; van Dam H; Boot A J; Bos J L; Zantema A; van der Eb A J
Co-regulated expression of junB and MHC class I genes in adenovirus-transformed cells.
Oncogene 1991;6(6):911-6.
1991: Burgering B M; Medema R H; Maassen J A; van de Wetering M L; van der Eb A J; McCormick F; Bos J L
Insulin stimulation of gene expression mediated by p21ras activation.
The EMBO journal 1991;10(5):1103-9.
1990: van Dam H; Offringa R; Meijer I; Stein B; Smits A M; Herrlich P; Bos J L; van der Eb A J
Differential effects of the adenovirus E1A oncogene on members of the AP-1 transcription factor family.
Molecular and cellular biology 1990;10(11):5857-64.
1990: Offringa R; Gebel S; van Dam H; Timmers M; Smits A; Zwart R; Stein B; Bos J L; van der Eb A; Herrlich P
A novel function of the transforming domain of E1a: repression of AP-1 activity.
Cell 1990;62(3):527-38.
1990: Timmers H T; Pronk G J; Bos J L; van der Eb A J
Analysis of the rat JE gene promoter identifies an AP-1 binding site essential for basal expression but not for TPA induction.
Nucleic acids research 1990;18(1):23-34.
1989: Burgering B M; Snijders A J; Maassen J A; van der Eb A J; Bos J L
Possible involvement of normal p21 H-ras in the insulin/insulinlike growth factor 1 signal transduction pathway.
Molecular and cellular biology 1989;9(10):4312-22.
1989: van Dam H; Offringa R; Smits A M; Bos J L; Jones N C; van der Eb A J
The repression of the growth factor-inducible genes JE, c-myc and stromelysin by adenovirus E1A is mediated by conserved region 1.
Oncogene 1989;4(10):1207-12.
1989: Meijer I; Jochemsen A G; de Wit C M; Bos J L; Morello D; van der Eb A J
Adenovirus type 12 E1A down regulates expression of a transgene under control of a major histocompatibility complex class I promoter: evidence for transcriptional control.
Journal of virology 1989;63(9):4039-42.
1989: van 't Veer L J; Burgering B M; Versteeg R; Boot A J; Ruiter D J; Osanto S; Schrier P I; Bos J L
N-ras mutations in human cutaneous melanoma from sun-exposed body sites.
Molecular and cellular biology 1989;9(7):3114-6.
1989: Timmers H T; van Dam H; Pronk G J; Bos J L; Van der Eb A J
Adenovirus E1A represses transcription of the cellular JE gene.
Journal of virology 1989;63(3):1470-3.
1988: Offringa R; Smits A M; Houweling A; Bos J L; van der Eb A J
Similar effects of adenovirus E1A and glucocorticoid hormones on the expression of the metalloprotease stromelysin.
Nucleic acids research 1988;16(23):10973-84.
1988: Smit V T; Boot A J; Smits A M; Fleuren G J; Cornelisse C J; Bos J L
KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas.
Nucleic acids research 1988;16(16):7773-82.
1988: Bos J L
The ras gene family and human carcinogenesis.
Mutation research 1988;195(3):255-71.
1988: van 't Veer L J; Hermens R; van den Berg-Bakker L A; Cheng N C; Fleuren G J; Bos J L; Cleton F J; Schrier P I
ras oncogene activation in human ovarian carcinoma.
Oncogene 1988;2(2):157-65.
1988: Timmers H T; van Zoelen E J; Bos J L; van der Eb A J
Cells transformed by adenovirus type 12 but not by type 5 are dependent on insulin or insulin-like growth factor I for their proliferation.
The Journal of biological chemistry 1988;263(3):1329-35.
1988: Van der Lubbe J L; Rosdorff H J; Bos J L; Van der Eb A J
Activation of N-ras induced by ultraviolet irradiation in vitro.
Oncogene research 1988;3(1):9-20.
1988: Timmers H T; De Wit D; Bos J L; Van der Eb A J
E1A products of adenoviruses reduce the expression of cellular proliferation-associated genes.
Oncogene research 1988;3(1):67-76.
1987: Jochemsen A G; Peltenburg L T; te Pas M F; de Wit C M; Bos J L; van der Eb A J
Activation of adenovirus 5 E1A transcription by region E1B in transformed primary rat cells.
The EMBO journal 1987;6(11):3399-405.
1986: Jochemsen A G; de Wit C M; Bos J L; van der Eb A J
Transforming properties of a 15-kDa truncated Ad12 E1A gene product.
Virology 1986;152(2):375-83.
1983: Bos J L; ten Wolde-Kraamwinkel H C
The E1b promoter of Ad12 in mouse L tk- cells is activated by adenovirus region E1a.
The EMBO journal 1983;2(1):73-6.

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