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Harukuni Tokuda

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Verena K Recke; Nobutaka Suzuki; Christoph Syldatk; Harukuni Tokuda; Victor Wray; Catharina Beyrle; Melanie Gerlitzki; Rudolf Hausmann; Siegmund Lang
Lipase-catalyzed acylation of microbial mannosylerythritol lipids (biosurfactants) and their characterization.
Diego Colombo; Clarissa Gagliardi; Takao Konoshima; Fiamma Ronchetti; Nobutaka Suzuki; Midori Takasaki; Maria Vetro; Harukuni Tokuda
New 6-amino-6-deoxy-glycoglycerolipids derived from 2-O-β-d-glucopyranosylglycerol: insights into the structure-activity relationship of glycoglycerolipids as anti-tumor promoters.
Hiroaki Kamachi; Akira Murakami; Kazuma Murakami; Yu Nakagawa; Nobutaka Suzuki; Keisuke Tanaka; Harukuni Tokuda; Ryo C Yanagita; Kazuhiro Irie
Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity.

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2013: Verena K Recke; Nobutaka Suzuki; Christoph Syldatk; Harukuni Tokuda; Victor Wray; Catharina Beyrle; Melanie Gerlitzki; Rudolf Hausmann; Siegmund Lang
Lipase-catalyzed acylation of microbial mannosylerythritol lipids (biosurfactants) and their characterization.
Carbohydrate research 2013;373():82-8.
2013: Diego Colombo; Clarissa Gagliardi; Takao Konoshima; Fiamma Ronchetti; Nobutaka Suzuki; Midori Takasaki; Maria Vetro; Harukuni Tokuda
New 6-amino-6-deoxy-glycoglycerolipids derived from 2-O-β-d-glucopyranosylglycerol: insights into the structure-activity relationship of glycoglycerolipids as anti-tumor promoters.
Carbohydrate research 2013;373():64-74.
2013: Hiroaki Kamachi; Akira Murakami; Kazuma Murakami; Yu Nakagawa; Nobutaka Suzuki; Keisuke Tanaka; Harukuni Tokuda; Ryo C Yanagita; Kazuhiro Irie
Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity.
Bioorganic & medicinal chemistry 2013;21(10):2695-702.
2013: Harukuni Tokuda; Andrea Vasas; Ilona Mucsi; Ulrike Olszewski; Nobutaka Suzuiki; Leonard Amaral; Helga Engi; Gerhard Hamilton; Judit Hohmann; Takashi Maoka; Joseph Molnar
Effects of Two Disiloxanes ALIS-409 and ALIS-421 on Chemoprevention in Model Experiments.
Anticancer research 2013;33(5):2021-7.
2013: Toshihiro Akihisa; Makoto Fukatsu; Takashi Kikuchi; Kazuo Koike; Masahiro Matsumoto; Yasuhiro Nakamura; Eri Ogihara; Xin Pan; Nami Takahashi; Harukuni Tokuda
Limonoids from the fruits of Melia azedarach and their cytotoxic activities.
Phytochemistry 2013;89():59-70.
2013: Govind J Kapadia; Takao Konoshima; N Suzuki; M Takasaki; Junko Takayasu; A Iida; G S Rao; Harukuni Tokuda
Evaluation of skin cancer chemoprevention potential of sunscreen agents using the Epstein-Barr virus early antigen activation in vitro assay.
International journal of cosmetic science 2013;35(2):143-8.
2013: Toshihiro Akihisa; Hiroyuki Akazawa; Makoto Fukatsu; Kohta Kawashima; Masahiro Matsumoto; Eri Ogihara; Masashi Orido; Harukuni Tokuda; Ayako Yamamoto; Jizaemon Fuji
Antioxidative and melanogenesis-inhibitory activities of caffeoylquinic acids and other compounds from moxa.
Chemistry & biodiversity 2013;10(3):313-27.
2013: Pawel T Szymanski; Harukuni Tokuda; Safwat A Ahmed; Eiichiro Ichiishi; Akira Iida; Sherief I Khalifa; Nobutaka Suzuki; Hesham Fahmy
Chemopreventive effect of sarcophine-diol on NOR-1-induced TPA-promoted skin carcinogenesis in female HOS:HR-1 mice.
Natural product communications 2013;8(2):153-4.
2013: Takashi Maoka; Aya Ohmori; Ayako Osawa; Kazutoshi Shindo; Nobutaka Suzuki; Harukuni Tokuda; Hiroyuki Yasui; Takashi Ishibashi
Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin.
Journal of oleo science 2013;62(3):181-6.
2012: Mohamed A Omar; Raghda A Ramadan; Yasser M Shaker; Harukuni Tokuda; Mamdouh M Ali; Shadia A Galal; Sean M Kerwin; Jing Li; Hoda I El-Diwani
Synthesis and docking studies of novel antitumor benzimidazoles.
Bioorganic & medicinal chemistry 2012;20(24):6989-7001.
2012: Masayuki Kikumori; Hiroshi Nagai; Kiyotake Suenaga; Nobutaka Suzuki; Harukuni Tokuda; Ryo C Yanagita; Kazuhiro Irie
Structure-activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activity.
Journal of medicinal chemistry 2012;55(11):5614-26.
2012: Takashi Maoka; Nobutaka Suzuki; Harukuni Tokuda; Hideaki Kato; Hideo Etoh
Anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of nitroastaxanthin and nitrolutein, the reaction products of astaxanthin and lutein with peroxynitrite.
Marine drugs 2012;10(6):1391-9.
2012: Toshihiro Akihisa; Makoto Fukatsu; Takashi Kikuchi; Nami Takahashi; Shun Tochizawa; Harukuni Tokuda; Ayako Yamamoto; Jie Zhang; Nobutaka Suzuki
Melanogenesis-inhibitory saccharide fatty acid esters and other constituents of the fruits of Morinda citrifolia (noni).
Chemistry & biodiversity 2012;9(6):1172-87.
2012: Hiroyuki Akazawa; Yumiko Kimura; Hideki Kohno; Aranya Manosroi; Jiradej Manosroi; Nobutaka Suzuki; Harukuni Tokuda; Ken Yasukawa; Toshihiro Akihisa
Anti-inflammatory and anti-tumor-promoting effects of 5-deprenyllupulonol C and other compounds from Hop (Humulus lupulus L.).
Chemistry & biodiversity 2012;9(6):1045-54.
2012: Jie Zhang; Yan Huang; Kei-ichiro Inafuku; Takashi Kikuchi; Motofumi Miura; Shigeyasu Motohashi; Nobutaka Suzuki; Takashi Suzuki; Harukuni Tokuda; Toshihiro Akihisa
Cucurbitane triterpenoids from the leaves of Momordica charantia, and their cancer chemopreventive effects and cytotoxicities.
Chemistry & biodiversity 2012;9(2):428-40.
2012: Toshihiro Akihisa; Makoto Fukatsu; Takashi Kikuchi; Toshihiro Motoi; Akihito Seki; Nobutaka Suzuki; Harukuni Tokuda; Yumiko Kimura
Cytotoxic activities and anti-tumor-promoting effects of microbial transformation products of prenylated chalcones from Angelica keiskei.
Chemistry & biodiversity 2012;9(2):318-30.
2012: József Molnár; Péter Molnár; József Deli; Györgyi Horváth; Takashi Maoka; Rozália Pusztai; Julianna Serly; Harukuni Tokuda; Irén Vincze; Attila Zalatnai; Hoyoku Nishino
Putative supramolecular complexes formed by carotenoids and xanthophylls with ascorbic acid to reverse multidrug resistance in cancer cells.
Anticancer research 2012;32(2):507-17.
2012: Sayo Ueno; Ryo C Yanagita; Takeshi Fujiwara; Akira Murakami; Kazuma Murakami; Nobutaka Suzuki; Harukuni Tokuda; Kazuhiro Irie
Identification and biological activities of bryostatins from Japanese bryozoan.
Bioscience, biotechnology, and biochemistry 2012;76(5):1041-3.
2011: Makoto Tsuboi; Hideo Etoh; Masashi Hosokawa; Hideki Kato; Kyuki Kato; Yasunori Maejima; Gaku Matsumoto; Kazuo Miyashita; Hironobu Mori; Hiroki Nakatugawa; Nobukuni Suzuki; Harukuni Tokuda; Takashi Maoka
Nitrocapsanthin and nitrofucoxanthin, respective products of capsanthin and fucoxanthin reaction with peroxynitrite.
Journal of agricultural and food chemistry 2011;59(19):10572-8.
2011: Reiko Tanaka; Harukuni Tokuda; Hiroko Tsujii; Takeshi Yamada; Takanari Arai; Yoshio Hamashima; Junya Hasegawa; Tetsuya Kajimoto; Nobutaka Suzuki; Manabu Node
Conjugates of 3α-methoxyserrat-14-en-21β-ol (PJ-1) and 3β-methoxyserrat-14-en-21β-ol (PJ-2) as cancer chemopreventive agents.
European journal of medicinal chemistry 2011;46(8):3368-75.
2011: Marvin J Núñez; Carolina P Reyes; Ignacio A Jiménez; Hirotaka Hayashi; Harukuni Tokuda; Isabel L Bazzocchi
ent-Rosane and abietane diterpenoids as cancer chemopreventive agents.
Phytochemistry 2011;72(4-5):385-90.
2011: Govind J Kapadia; Magnus A Azuine; G Subba Rao; Takanari Arai; Akira Iida; Harukuni Tokuda
Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer cell lines.
Anti-cancer agents in medicinal chemistry 2011;11(3):280-4.
2011: Mitsuaki Yamashita; Koichi Sakaguchi; Harukuni Tokuda; Kazunori Ueda; Akira Iida
One-pot synthesis of benzo[f]indole-4,9-diones from 1,4-naphthoquinones and terminal acetylenes.
Chemical & pharmaceutical bulletin 2011;59(10):1289-93.
2011: Yu Nakagawa; Harukuni Tokuda; Ryo C Yanagita; Masayuki Kikumori; Akira Murakami; Hiroshi Nagai; Kazuhiro Irie
Synthesis and biological evaluation of the 12,12-dimethyl derivative of Aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin.
Bioscience, biotechnology, and biochemistry 2011;75(6):1167-73.
2011: Toshihiro Akihisa; Akitomo Takahashi; Takashi Kikuchi; Mio Takagi; Kensuke Watanabe; Makoto Fukatsu; Yukiko Fujita; Norihiro Banno; Harukuni Tokuda; Ken Yasukawa
The melanogenesis-inhibitory, anti-inflammatory, and chemopreventive effects of limonoids in n-hexane extract of Azadirachta indica A. Juss. (neem) seeds.
Journal of oleo science 2011;60(2):53-9.
2011: Shadia A Galal; Ahmed S Abdelsamie; Harukuni Tokuda; Nobutaka Suzuki; Akira Lida; Mahmoud M Elhefnawi; Raghda A Ramadan; Mona H E Atta; Hoda I El-Diwani
Part I: Synthesis, cancer chemopreventive activity and molecular docking study of novel quinoxaline derivatives.
European journal of medicinal chemistry 2011;46(1):327-40.
2010: Ryo C Yanagita; Hiroaki Kamachi; Keisuke Tanaka; Akira Murakami; Yu Nakagawa; Harukuni Tokuda; Hiroshi Nagai; Kazuhiro Irie
Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity.
Bioorganic & medicinal chemistry letters 2010;20(20):6064-6.
2010: Shun-ichi Wada; Teppei Hitomi; Harukuni Tokuda; Reiko Tanaka
Anti-tumor-initiating effects of spiro-biflavonoids from Abies sachalinensis.
Chemistry & biodiversity 2010;7(9):2303-8.
2010: Motohiko Ukiya; Takashi Kikuchi; Harukuni Tokuda; Keiichi Tabata; Yumiko Kimura; Takanari Arai; Yoichiro Ezaki; Osamu Oseto; Takashi Suzuki; Toshihiro Akihisa
Antitumor-promoting effects and cytotoxic activities of dammar resin triterpenoids and their derivatives.
Chemistry & biodiversity 2010;7(8):1871-84.
2010: Hiroko Tsujii; Takeshi Yamada; Tetsuya Kajimoto; Reiko Tanaka; Harukuni Tokuda; Junya Hasegawa; Yoshio Hamashima; Manabu Node
Hybrids of 3alpha-methoxyserrat-14-en-21beta-ol (PJ-1) and 3beta-methoxyserrat-14-en-21beta-ol (PJ-2) and various anti-oxidants as cancer chemopreventive agents.
European journal of medicinal chemistry 2010;45(6):2191-7.
2010: Govind J Kapadia; Magnus A Azuine; Yuuko Shigeta; Nobutaka Suzuki; Harukuni Tokuda
Chemopreventive activities of etodolac and oxyphenbutazone against mouse skin carcinogenesis.
Bioorganic & medicinal chemistry letters 2010;20(8):2546-8.
2010: Jin Tatsuzaki; Kyoko Goto; Harukuni Tokuda; Kuo-Hsiung Lee
Cancer preventive agents 10. Prenylated dehydrozingerone analogs as potent chemopreventive agents.
Journal of Asian natural products research 2010;12(3):227-32.
2010: Nayra R Perestelo; Ignacio A Jiménez; Harukuni Tokuda; Hirotaka Hayashi; Isabel L Bazzocchi
Sesquiterpenes from Maytenus jelskii as potential cancer chemopreventive agents.
Journal of natural products 2010;73(2):127-32.
2010: Toshihiro Akihisa; Nobuo Kojima; Takashi Kikuchi; Ken Yasukawa; Harukuni Tokuda; Eliot T Masters; Aranya Manosroi; Jiradej Manosroi
Anti-inflammatory and chemopreventive effects of triterpene cinnamates and acetates from shea fat.
Journal of oleo science 2010;59(6):273-80.
2010: Yoshiaki Miyake; Chihiro Ito; Harukuni Tokuda; Toshihiko Osawa; Masataka Itoigawa
Evaluation of flavoglaucin, its derivatives and pyranonigrins produced by molds used in fermented foods for inhibiting tumor promotion.
Bioscience, biotechnology, and biochemistry 2010;74(5):1120-2.
2009: Toshihiro Akihisa; Emiko Uchiyama; Takashi Kikuchi; Harukuni Tokuda; Takashi Suzuki; Yumiko Kimura
Anti-tumor-promoting effects of 25-methoxyporicoic acid A and other triterpene acids from Poria cocos.
Journal of natural products 2009;72(10):1786-92.
2009: Mitsuaki Yamashita; Masafumi Kaneko; Harukuni Tokuda; Katsumi Nishimura; Yuko Kumeda; Akira Iida
Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae.
Bioorganic & medicinal chemistry 2009;17(17):6286-91.
2009: Shun-ichi Wada; Yumiko Yasui; Harukuni Tokuda; Reiko Tanaka
Anti-tumor-initiating effects of phenolic compounds isolated from the bark of Picea jezoensis var. jezoensis.
Bioorganic & medicinal chemistry 2009;17(17):6414-21.
2009: Mehrdad Iranshahi; Amirhossein Sahebkar; Midori Takasaki; Takao Konoshima; Harukuni Tokuda
Cancer chemopreventive activity of the prenylated coumarin, umbelliprenin, in vivo.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2009;18(5):412-5.
2009: Milind Dangate; Laura Franchini; Fiamma Ronchetti; Takanari Arai; Akira Iida; Harukuni Tokuda; Diego Colombo
2-O-beta-d-glucopyranosyl-sn-glycerol based analogues of sulfoquinovosyldiacylglycerols (SQDG) and their role in inhibiting Epstein-Barr virus early antigen activation.
Bioorganic & medicinal chemistry 2009;17(16):5968-73.
2009: Chiharu Yamaguchi; Yasuko In; Shun-ichi Wada; Takeshi Yamada; Harukuni Tokuda; Reiko Tanaka
Cancer chemopreventive activity of oleanane-type triterpenoids from the stem bark of Betula ermanii.
Chemistry & biodiversity 2009;6(7):1093-100.
2009: Kyoko Goto; Koji Yamada; Masahiko Taniguchi; Harukuni Tokuda; Kuo-Hsiung Lee
Cancer preventive agents 9. Betulinic acid derivatives as potent cancer chemopreventive agents.
Bioorganic & medicinal chemistry letters 2009;19(13):3378-81.
2009: Hoyoku Nishino; Michiaki Murakoshi; Harukuni Tokuda; Yoshiko Satomi
Cancer prevention by carotenoids.
Archives of biochemistry and biophysics 2009;483(2):165-8.
2009: Midori Takasaki; Takao Konoshima; Mutsuo Kozuka; Harukuni Tokuda; Junko Takayasu; Hoyoku Nishino; Masazumi Miyakoshi; Kenji Mizutani; Kuo-Hsiung Lee
Cancer preventive agents. Part 8: Chemopreventive effects of stevioside and related compounds.
Bioorganic & medicinal chemistry 2009;17(2):600-5.
2009: Toshihiro Akihisa; Taisuke Noto; Akitomo Takahashi; Yukiko Fujita; Norihiro Banno; Harukuni Tokuda; Kazuo Koike; Takashi Suzuki; Ken Yasukawa; Yumiko Kimura
Melanogenesis inhibitory, anti-inflammatory, and chemopreventive effects of limonoids from the seeds of Azadirachta indicia A. Juss. (neem).
Journal of oleo science 2009;58(11):581-94.
2009: Salwa F Farag; Yuka Kimura; Hideyuki Ito; Junko Takayasu; Harukuni Tokuda; Tsutomu Hatano
New isoflavone glycosides from Iris spuria L. (Calizona) cultivated in Egypt.
Journal of natural medicines 2009;63(1):91-5.
2008: Reiko Tanaka; Harukuni Tokuda; Yoichiro Ezaki
Cancer chemopreventive activity of "rosin" constituents of Pinus spez. and their derivatives in two-stage mouse skin carcinogenesis test.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2008;15(11):985-92.
2008: Sayaka Taji; Takeshi Yamada; Shun-Ichi Wada; Harukuni Tokuda; Kazuo Sakuma; Reiko Tanaka
Lanostane-type triterpenoids from the sclerotia of Inonotus obliquus possessing anti-tumor promoting activity.
European journal of medicinal chemistry 2008;43(11):2373-9.
2008: Kinuko Iwasa; Teturo Takahashi; Yumi Nishiyama; Masataka Moriyasu; Makiko Sugiura; Atsuko Takeuchi; Chisato Tode; Harukuni Tokuda; Kazuyoshi Takeda
Online structural elucidation of alkaloids and other constituents in crude extracts and cultured cells of Nandina domestica by combination of LC-MS/MS, LC-NMR, and LC-CD analyses.
Journal of natural products 2008;71(8):1376-85.
2008: Junko Koyama; Yu Nisino; Izumi Morita; Norihiro Kobayashi; Toshiyuki Osakai; Harukuni Tokuda
Correlation between reduction potentials and inhibitions of Epstein-Barr virus activation by anthraquinone derivatives.
Bioorganic & medicinal chemistry letters 2008;18(14):4106-9.
2008: Junko Koyama; Izumi Morita; Norihiro Kobayashi; Takao Konoshima; Midori Takasaki; Toshiyuki Osakai; Harukuni Tokuda
Correlation between oxidation potentials and inhibitory effects on Epstein-Barr virus activation of flavonoids.
Cancer letters 2008;263(1):61-6.
2008: Toru Yagura; Tomoko Motomiya; Michiho Ito; Gisho Honda; Akira Iida; Fumiyuki Kiuchi; Harukuni Tokuda; Hoyoku Nishino
Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum.
Journal of natural medicines 2008;62(2):174-8.
2008: Reiko Tanaka; Tomoko Nakata; Chiharu Yamaguchi; Shun-Ichi Wada; Takeshi Yamada; Harukuni Tokuda
Potential anti-tumor-promoting activity of 3alpha-hydroxy-D:A-friedooleanan-2-one from the stem bark of Mallotus philippensis.
Planta medica 2008;74(4):413-6.
2008: Mehrdad Iranshahi; Farhad Kalategi; Ramin Rezaee; Ahmad Reza Shahverdi; Chihiro Ito; Hiroshi Furukawa; Harukuni Tokuda; Masataka Itoigawa
Cancer chemopreventive activity of terpenoid coumarins from Ferula species.
Planta medica 2008;74(2):147-50.
2008: Diego Colombo; Patrizia Ferraboschi; Laura Franchini; Hoyoku Nishino; Junko Takayasu; Harukuni Tokuda
Anti-tumor-Promoting activity of tibolone and its metabolites.
Arzneimittel-Forschung 2008;58(2):86-90.
2007: Mitsuaki Yamashita; Masafumi Kaneko; Akira Iida; Harukuni Tokuda; Katsumi Nishimura
Stereoselective synthesis and cytotoxicity of a cancer chemopreventive naphthoquinone from Tabebuia avellanedae.
Bioorganic & medicinal chemistry letters 2007;17(23):6417-20.
2007: Wenhua Cui; Kinuko Iwasa; Makiko Sugiura; Atsuko Takeuchi; Chisato Tode; Yumi Nishiyama; Masataka Moriyasu; Harukuni Tokuda; Kazuyoshi Takeda
Biotransformation of phenolic 1-benzyl-N-methyltetrahydroisoquinolines in plant cell cultures followed by LC/NMR, LC/MS, and LC/CD.
Journal of natural products 2007;70(11):1771-8.
2007: Toshihiro Akihisa; Naoki Higo; Harukuni Tokuda; Motohiko Ukiya; Hiroyuki Akazawa; Yuichi Tochigi; Yumiko Kimura; Takashi Suzuki; Hoyoku Nishino
Cucurbitane-type triterpenoids from the fruits of Momordica charantia and their cancer chemopreventive effects.
Journal of natural products 2007;70(8):1233-9.
2007: Chihiro Ito; Masataka Itoigawa; Tetsufumi Kanematsu; Yuuki Imamura; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Synthetic cinnamylphenol derivatives as cancer chemopreventive agents.
European journal of medicinal chemistry 2007;42(7):902-9.
2007: Takashi Kikuchi; Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Kenji Watanabe; Hoyoku Nishino
Cancer chemopreventive effects of cycloartane-type and related triterpenoids in in vitro and in vivo models.
Journal of natural products 2007;70(6):918-22.
2007: Toshihiro Akihisa; Yuji Nakamura; Harukuni Tokuda; Emiko Uchiyama; Takashi Suzuki; Yumiko Kimura; Kazuo Uchikura; Hoyoku Nishino
Triterpene acids from Poria cocos and their anti-tumor-promoting effects.
Journal of natural products 2007;70(6):948-53.
2007: Manabu Nishizawa; Hironori Ohtsu; Reiko Tanaka; Harukuni Tokuda; Takahiro Katoh; Masatoshi Takeo; Manabu Node
Oral administration of (11E)-13-oxo-15,16-dinorlabda-8(20),11-dien-19-oic acid strongly reduces photocarcinogenesis in mouse skin exposed to UV-B irradiation.
Chemistry & biodiversity 2007;4(5):1003-7.
2007: Toshihiro Akihisa; Kazumi Matsumoto; Harukuni Tokuda; Ken Yasukawa; Ken-ichi Seino; Katsuo Nakamoto; Hideki Kuninaga; Takashi Suzuki; Yumiko Kimura
Anti-inflammatory and potential cancer chemopreventive constituents of the fruits of Morinda citrifolia (Noni).
Journal of natural products 2007;70(5):754-7.
2007: Toshihiro Akihisa; Yosuke Hayakawa; Harukuni Tokuda; Norihiro Banno; Naoto Shimizu; Takashi Suzuki; Yumiko Kimura
Cucurbitane glycosides from the fruits of Siraitia gros venorii and their inhibitory effects on Epstein-Barr virus activation.
Journal of natural products 2007;70(5):783-8.
2007: Toshihiro Akihisa; Yuji Nakamura; Masaaki Tagata; Harukuni Tokuda; Ken Yasukawa; Emiko Uchiyama; Takashi Suzuki; Yumiko Kimura
Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum.
Chemistry & biodiversity 2007;4(2):224-31.
2007: Hoyoku Nishino; Yoshiko Satomi; Harukuni Tokuda; Mitsuharu Masuda
Cancer control by phytochemicals.
Current pharmaceutical design 2007;13(33):3394-9.
2007: Tomoko Nakata; Takeshi Yamada; Sayaka Taji; Hirofumi Ohishi; Shun-Ichi Wada; Harukuni Tokuda; Kazuo Sakuma; Reiko Tanaka
Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus.
Bioorganic & medicinal chemistry 2007;15(1):257-64.
2006: Motohiko Ukiya; Toshihiro Akihisa; Ken Yasukawa; Harukuni Tokuda; Takashi Suzuki; Yumiko Kimura
Anti-inflammatory, anti-tumor-promoting, and cytotoxic activities of constituents of marigold (Calendula officinalis) flowers.
Journal of natural products 2006;69(12):1692-6.
2006: Diego Colombo; Laura Franchini; Lucio Toma; Fiamma Ronchetti; Reiko Tanaka; Junko Takayasu; Hoyoku Nishino; Harukuni Tokuda
Cyclic and branched acyl chain galactoglycerolipids and their effect on anti-tumor-promoting activity.
European journal of medicinal chemistry 2006;41(12):1456-63.
2006: Junko Koyama; Munetaka Inoue; Izumi Morita; Norihiro Kobayashi; Toshiyuki Osakai; Hoyoku Nishino; Harukuni Tokuda
Correlation between reduction potentials and inhibitory effects on Epstein-Barr virus activation by emodin derivatives.
Cancer letters 2006;241(2):263-7.
2006: Norihiro Banno; Toshihiro Akihisa; Ken Yasukawa; Harukuni Tokuda; Keiichi Tabata; Yuji Nakamura; Reiko Nishimura; Yumiko Kimura; Takashi Suzuki
Anti-inflammatory activities of the triterpene acids from the resin of Boswellia carteri.
Journal of ethnopharmacology 2006;107(2):249-53.
2006: Toshihiro Akihisa; Keiichi Tabata; Norihiro Banno; Harukuni Tokuda; Reiko Nishimura; Reiko Nishihara; Yuji Nakamura; Yumiko Kimura; Ken Yasukawa; Takashi Suzuki
Cancer chemopreventive effects and cytotoxic activities of the triterpene acids from the resin of Boswellia carteri.
Biological & pharmaceutical bulletin 2006;29(9):1976-9.
2006: Yuko Fukuda; Kuniyoshi Sakai; Shunyo Matsunaga; Harukuni Tokuda; Reiko Tanaka
Cancer chemopreventive effect of orally administrated lupane-type triterpenoid on ultraviolet light B induced photocarcinogenesis of hairless mouse.
Cancer letters 2006;240(1):94-101.
2006: Reiko Tanaka; Toshifumi Minami; Harukuni Tokuda
Anti-initiating activity of 3beta-methoxy-13alpha,14alpha-epoxyserratan-21beta-ol (PJJ-34) from the stem bark of Picea jezoensis Carr. var. jezoensis.
Chemistry & biodiversity 2006;3(7):818-24.
2006: Hui-Chi Huang; Wei-Jern Tsai; Susan L Morris-Natschke; Harukuni Tokuda; Kuo-Hsiung Lee; Yang-Chang Wu; Yueh-Hsiung Kuo
Sapinmusaponins F-J, bioactive tirucallane-type saponins from the galls of Sapindus mukorossi.
Journal of natural products 2006;69(5):763-7.
2006: Toshihiro Akihisa; Yosuke Taguchi; Ken Yasukawa; Harukuni Tokuda; Hiroyuki Akazawa; Takashi Suzuki; Yumiko Kimura
Acerogenin M, a cyclic diarylheptanoid, and other phenolic compounds from Acer nikoense and their anti-inflammatory and anti-tumor-promoting effects.
Chemical & pharmaceutical bulletin 2006;54(5):735-9.
2006: Masayuki Horiuchi; Harukuni Tokuda; Keiichiro Ohnishi; Masakazu Yamashita; Hoyoku Nishino; Takashi Maoka
Porritoxins, metabolites of Alternaria porri, as anti-tumor-promoting active compounds.
Natural product research 2006;20(2):161-6.
2006: Takeshi Ishikawa; Norimasa Yoshida; Harukuni Tokuda; Satoshi Kokura; Nami Nakabe; Masashi Kuchide; Eiichiro Ichiishi; Atsumune Imaeda; Hiroshi Ichikawa; Yuji Naito; Takeshi Okanoue; Toshikazu Yoshikawa
Role of oxygen-derived free radicals in Helicobacter pylori water extract-induced mouse skin carcinogenesis.
BioFactors (Oxford, England) 2006;28(1):1-7.
2006: Toshihiro Akihisa; Harukuni Tokuda; Daisuke Hasegawa; Motohiko Ukiya; Yumiko Kimura; Fumio Enjo; Takashi Suzuki; Hoyoku Nishino
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.
Journal of natural products 2006;69(1):38-42.
2006: Wenhua Cui; Kinuko Iwasa; Harukuni Tokuda; Akiko Kashihara; Yosuke Mitani; Tomoko Hasegawa; Yumi Nishiyama; Masataka Moriyasu; Hoyoku Nishino; Miyoji Hanaoka; Chisato Mukai; Kazuyoshi Takeda
Potential cancer chemopreventive activity of simple isoquinolines, 1-benzylisoquinolines, and protoberberines.
Phytochemistry 2006;67(1):70-9.
2005: Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Ayaka Kiyota; Ken Yasukawa; Naoyuki Sakamoto; Yumiko Kimura; Takashi Suzuki; Junko Takayasu; Hoyoku Nishino
Anti-tumor-initiating effects of monascin, an azaphilonoid pigment from the extract of Monascus pilosus fermented rice (red-mold rice).
Chemistry & biodiversity 2005;2(10):1305-9.
2005: Norihiro Banno; Toshihiro Akihisa; Harukuni Tokuda; Ken Yasukawa; Yosuke Taguchi; Hiroyuki Akazawa; Motohiko Ukiya; Yumiko Kimura; Takashi Suzuki; Hoyoku Nishino
Anti-inflammatory and antitumor-promoting effects of the triterpene acids from the leaves of Eriobotrya japonica.
Biological & pharmaceutical bulletin 2005;28(10):1995-9.
2005: Junko Koyama; Izumi Morita; Norihiro Kobayashi; Toshiyuki Osakai; Hoyoku Nishino; Harukuni Tokuda
Correlation between reduction potentials and inhibitory effects on Epstein-Barr virus activation of poly-substituted anthraquinones.
Cancer letters 2005;225(2):193-8.
2005: Seikou Nakamura; Mutsuo Kozuka; Kenneth F Bastow; Harukuni Tokuda; Hoyoku Nishino; Madoka Suzuki; Jin Tatsuzaki; Susan L Morris-Natschke; Sheng-Chu Kuo; Kuo-Hsiung Lee
Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters.
Bioorganic & medicinal chemistry 2005;13(14):4396-401.
2005: Kyoko Goto; Kenneth F Bastow; Jiu-Hong Wu; Harukuni Tokuda; Kuo-Hsiung Lee
Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs.
Bioorganic & medicinal chemistry letters 2005;15(12):3016-9.
2005: Toshihiro Akihisa; Scott Franzblau; Harukuni Tokuda; Masaaki Tagata; Motohiko Ukiya; Tsunetomo Matsuzawa; Koichi Metori; Yumiko Kimura; Takashi Suzuki; Ken Yasukawa
Antitubercular activity and inhibitory effect on Epstein-Barr virus activation of sterols and polyisoprenepolyols from an edible mushroom, Hypsizigus marmoreus.
Biological & pharmaceutical bulletin 2005;28(6):1117-9.
2005: Yumiko Kimura; Toshihiro Akihisa; Noriko Yuasa; Motohiko Ukiya; Takashi Suzuki; Masaharu Toriyama; Shigeyasu Motohashi; Harukuni Tokuda
Cucurbitane-type triterpenoids from the fruit of Momordica charantia.
Journal of natural products 2005;68(5):807-9.
2005: Toshihiro Akihisa; Masaaki Tagata; Motohiko Ukiya; Harukuni Tokuda; Takashi Suzuki; Yumiko Kimura
Oxygenated lanostane-type triterpenoids from the fungus ganodermalucidum.
Journal of natural products 2005;68(4):559-63.
2005: Yuko Fukuda; Kuniyoshi Sakai; Shunyo Matsunaga; Harukuni Tokuda; Reiko Tanaka
Cancer chemopreventive activity of lupane- and oleanane-type triterpenoids from the cones of Liquidamber styraciflua.
Chemistry & biodiversity 2005;2(3):421-8.
2005: Chihiro Ito; Masataka Itoigawa; Saori Onoda; Atsuko Hosokawa; Nijsiri Ruangrungsi; Toshimitsu Okuda; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Chemical constituents of Murraya siamensis: three coumarins and their anti-tumor promoting effect.
Phytochemistry 2005;66(5):567-72.
2005: Nobuko Sakurai; Mutsuo Kozuka; Harukuni Tokuda; Teruo Mukainaka; Fumio Enjo; Hoyoku Nishino; Masahiro Nagai; Yojiro Sakurai; Kuo-Hsiung Lee
Cancer preventive agents. Part 1: chemopreventive potential of cimigenol, cimigenol-3,15-dione, and related compounds.
Bioorganic & medicinal chemistry 2005;13(4):1403-8.
2005: Toshihiro Akihisa; Harukuni Tokuda; Ken Yasukawa; Motohiko Ukiya; Ayaka Kiyota; Naoyuki Sakamoto; Takashi Suzuki; Nobukazu Tanabe; Hoyoku Nishino
Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice (red-mold rice) and their chemopreventive effects.
Journal of agricultural and food chemistry 2005;53(3):562-5.
2005: Cristina R Mendoza; Ignacio A Jiménez; Harukuni Tokuda; Hiroyuki Kushida; Isabel L Bazzocchi
Antitumor-promoting effects of new sesquiterpenes from Crossopetalum tonduzii.
Chemistry & biodiversity 2005;2(2):286-94.
2005: Chihiro Ito; Masataka Itoigawa; Motoharu Ju-ichi; Naoyuki Sakamoto; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Antitumor-promoting activity of coumarins from citrus plants.
Planta medica 2005;71(1):84-7.
2005: Diego Colombo; Laura Franchini; Lucio Toma; Fiamma Ronchetti; Nami Nakabe; Takao Konoshima; Hoyoku Nishino; Harukuni Tokuda
Anti-tumor-promoting activity of simple models of galactoglycerolipids with branched and unsaturated acyl chains.
European journal of medicinal chemistry 2005;40(1):69-74.
2004: Reiko Tanaka; Yoshitaka Kinouchi; Shun-ichi Wada; Harukuni Tokuda
Potential anti-tumor promoting activity of lupane-type triterpenoids from the stem bark of Glochidion zeylanicum and Phyllanthus flexuosus.
Planta medica 2004;70(12):1234-6.
2004: Wataru Aoi; Eiichiro Ichiishi; Naoyuki Sakamoto; Atsumi Tsujimoto; Harukuni Tokuda; Toshikazu Yoshikawa
Effect of exercise on hepatic gene expression in rats: a microarray analysis.
Life sciences 2004;75(26):3117-28.
2004: Masataka Itoigawa; Chihiro Ito; Harukuni Tokuda; Fumio Enjo; Hoyoku Nishino; Hiroshi Furukawa
Cancer chemopreventive activity of phenylpropanoids and phytoquinoids from Illicium plants.
Cancer letters 2004;214(2):165-9.
2004: Reiko Tanaka; Kandasamy Shanmugasundaram; Chiharu Yamaguchi; Yohei Ishikawa; Harukuni Tokuda; Kiyoharu Nishide; Manabu Node
Cancer chemopreventive activity of 3beta-methoxyserrat-14-en-21beta-ol and several serratane analogs on two-stage mouse skin carcinogenesis.
Cancer letters 2004;214(2):149-56.
2004: Chihiro Murakami; Narihiko Fukamiya; Sadaaki Tamura; Masayoshi Okano; Kenneth F Bastow; Harukuni Tokuda; Teruo Mukainaka; Hoyoky Nishino; Kuo-Hsiung Lee
Multidrug-resistant cancer cell susceptibility to cytotoxic quassinoids, and cancer chemopreventive effects of quassinoids and canthin alkaloids.
Bioorganic & medicinal chemistry 2004;12(18):4963-8.
2004: Reiko Tanaka; Shun-ichi Wada; Yoshitaka Kinouchi; Harukuni Tokuda; Shunyo Matsunaga
A new seco-abietane-type diterpene from the stem bark of Picea glehni.
Planta medica 2004;70(9):877-80.
2004: Chihiro Ito; Masataka Itoigawa; Atsuko Sato; Choudhury M Hasan; Mohammad A Rashid; Harukuni Tokuda; Teruo Mukainaka; Hoyoku Nishino; Hiroshi Furukawa
Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.
Journal of natural products 2004;67(9):1488-91.
2004: Junko Koyama; Izumi Morita; Norihiro Kobayashi; Toshiyuki Osakai; Hiroki Hotta; Junko Takayasu; Hoyoku Nishino; Harukuni Tokuda
Correlation of redox potentials and inhibitory effects on Epstein-Barr virus activation of 2-azaanthraquinones.
Cancer letters 2004;212(1):1-6.
2004: Chihiro Ito; Masataka Itoigawa; Naoki Kojima; Harukuni Tokuda; Tetsurou Hirata; Hoyoku Nishino; Hiroshi Furukawa
Chemical constituents of Millettia taiwaniana: structure elucidation of five new isoflavonoids and their cancer chemopreventive activity.
Journal of natural products 2004;67(7):1125-30.
2004: Reiko Tanaka; Toshifumi Minami; Yohei Ishikawa; Harukuni Tokuda; Shunyo Matsunaga
Cancer chemopreventive activity of serratane-type triterpenoids from Picea jezoensis.
Chemistry & biodiversity 2004;1(6):878-85.
2004: Chihiro Ito; Masataka Itoigawa; Naoki Kojima; Hugh T-W Tan; Junko Takayasu; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Cancer chemopreventive activity of rotenoids from Derris trifoliata.
Planta medica 2004;70(6):585-8.
2004: Toshihiro Akihisa; Harukuni Tokuda; Masakazu Ogata; Motohiko Ukiya; Masao Iizuka; Takashi Suzuki; Koichi Metori; Naoto Shimizu; Hoyoku Nishino
Cancer chemopreventive effects of polyunsaturated fatty acids.
Cancer letters 2004;205(1):9-13.
2004: Toshihiro Akihisa; Shoichi Mafune; Motohiko Ukiya; Yumiko Kimura; Ken Yasukawa; Takashi Suzuki; Harukuni Tokuda; Nobukazu Tanabe; Tadahiko Fukuoka
(+)- and (-)-syn-2-isobutyl-4-methylazetidine-2,4-dicarboxylic acids from the extract of Monascus pilosus-fermented rice (red-mold rice).
Journal of natural products 2004;67(3):479-80.
2004: Hideyuki Ito; Naoki Kasajima; Harukuni Tokuda; Hoyoku Nishino; Takashi Yoshida
Dimeric flavonol glycoside and galloylated C-glucosylchromones from Kunzea ambigua.
Journal of natural products 2004;67(3):411-5.
2004: Toshihiro Akihisa; Yusuke Hamasaki; Harukuni Tokuda; Motohiko Ukiya; Yumiko Kimura; Hoyoku Nishino
Microbial transformation of isosteviol and inhibitory effects on Epstein-Barr virus activation of the transformation products.
Journal of natural products 2004;67(3):407-10.
2004: Magnus A Azuine; Harukuni Tokuda; Junko Takayasu; Fumio Enjyo; Teruo Mukainaka; Takao Konoshima; Hoyoku Nishino; Govind J Kapadia
Cancer chemopreventive effect of phenothiazines and related tri-heterocyclic analogues in the 12-O-tetradecanoylphorbol-13-acetate promoted Epstein-Barr virus early antigen activation and the mouse skin two-stage carcinogenesis models.
Pharmacological research : the official journal of the Italian Pharmacological Society 2004;49(2):161-9.
2004: Rikako Suzuki; Hiroyuki Kohno; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi; Masamichi Yano; Harukuni Tokuda; Hoyoku Nishino; Takuji Tanaka
Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats.
BioFactors (Oxford, England) 2004;22(1-4):111-4.
2004: Hoyoku Nishino; Harukuni Tokuda; Yoshiko Satomi; Mitsuharu Masuda; Yasuhito Osaka; Shingo Yogosawa; Saeri Wada; Xiao Yang Mou; Junko Takayasu; Michiaki Murakoshi; Kenji Jinnno; Masamichi Yano
Cancer prevention by antioxidants.
BioFactors (Oxford, England) 2004;22(1-4):57-61.
2004: Chihiro Ito; Masataka Itoigawa; Naoki Kojima; Hugh T-W Tan; Junko Takayasu; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Cancer chemopreventive activity of rotenoids from Derris trifoliata.
Planta medica 2004;70(1):8-11.
2004: Norihiro Banno; Toshihiro Akihisa; Harukuni Tokuda; Ken Yasukawa; Hiroshi Higashihara; Motohiko Ukiya; Kenji Watanabe; Yumiko Kimura; Jun-Ichi Hasegawa; Hoyoku Nishino
Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects.
Bioscience, biotechnology, and biochemistry 2004;68(1):85-90.
2004: Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Toshie Suzuki; Fumio Enjo; Kazuo Koike; Tamotsu Nikaido; Hoyoku Nishino
3-epicabraleahydroxylactone and other triterpenoids from camellia oil and their inhibitory effects on Epstein-Barr virus activation.
Chemical & pharmaceutical bulletin 2004;52(1):153-6.
2003: Kenji Iwatsuki; Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Manabu Oshikubo; Yumiko Kimura; Takeshi Asano; Atsushi Nomura; Hoyoku Nishino
Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation.
Journal of natural products 2003;66(12):1582-5.
2003: Chihiro Ito; Masataka Itoigawa; Tetsufumi Kanematsu; Nijsiri Ruangrungsi; Hiroshi Higashihara; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
New cinnamylphenols from Dalbergia species with cancer chemopreventive activity.
Journal of natural products 2003;66(12):1574-7.
2003: Shinichi Uesato; Keisuke Taniuchi; Ayako Kumagai; Yasuo Nagaoka; Ryota Seto; Yukihiko Hara; Harukuni Tokuda; Hoyoku Nishino
Inhibitory effects of 3-O-acyl-(+)-catechins on Epstein-Barr virus activation.
Chemical & pharmaceutical bulletin 2003;51(12):1448-50.
2003: Chihiro Ito; Masataka Itoigawa; Tetsufumi Kanematsu; Nijsiri Ruangrungsi; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Isoflavonoids from Dalbergia olivari.
Phytochemistry 2003;64(7):1265-8.
2003: Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Masao Iizuka; Stefan Schneider; Kazuya Ogasawara; Teruo Mukainaka; Kenji Iwatsuki; Takashi Suzuki; Hoyoku Nishino
Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects.
Cancer letters 2003;201(2):133-7.
2003: Ayako Kumagai; Yasuo Nagaoka; Tomoko Obayashi; Yasuhiro Terashima; Harukuni Tokuda; Yukihiko Hara; Teruo Mukainaka; Hoyoku Nishino; Hiroshi Kuwajima; Shinichi Uesato
Tumor chemopreventive activity of 3-O-acylated (--)-epigallocatechins.
Bioorganic & medicinal chemistry 2003;11(23):5143-8.
2003: Junko Koyama; Izumi Morita; Norihiro Kobayashi; Toshiyuki Osakai; Hiroki Hotta; Junko Takayasu; Hoyoku Nishino; Harukuni Tokuda
Correlation of redox potentials and inhibitory effects on Epstein-Barr virus activation of naphthoquinones.
Cancer letters 2003;201(1):25-30.
2003: Kenji Iwatsuki; Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Hiroshi Higashihara; Teruo Mukainaka; Masao Iizuka; Yoshiharu Hayashi; Yumiko Kimura; Hoyoku Nishino
Sterol ferulates, sterols, and 5-alk(en)ylresorcinols from wheat, rye, and corn bran oils and their inhibitory effects on Epstein-Barr virus activation.
Journal of agricultural and food chemistry 2003;51(23):6683-8.
2003: Reiko Tanaka; Yohei Ishikawa; Toshifumi Minami; Katsuhiko Minoura; Harukuni Tokuda; Shunyo Matsunaga
Two new anti-tumor promoting serratane-type triterpenoids from the stem bark of Picea jezoensis var. jezoensis.
Planta medica 2003;69(11):1041-7.
2003: Motohiko Ukiya; Toshihiro Akihisa; Harukuni Tokuda; Kazuo Koike; Yumiko Kimura; Takeshi Asano; Shigeyasu Motohashi; Tamotsu Nikaido; Hoyoku Nishino
Sunpollenol and five other rearranged 3,4-seco-tirucallane-type triterpenoids from sunflower pollen and their inhibitory effects on Epstein-Barr virus activation.
Journal of natural products 2003;66(11):1476-9.
2003: Junya Kuroda; Shinya Kimura; Hidekazu Segawa; Yutaka Kobayashi; Toshikazu Yoshikawa; Yoshimasa URASAKI; Takanori Ueda; Fumio Enjo; Harukuni Tokuda; Oliver G Ottmann; Taira Maekawa
The third-generation bisphosphonate zoledronate synergistically augments the anti-Ph+ leukemia activity of imatinib mesylate.
Blood 2003;102(6):2229-35.
2003: Intan Safinar Ismail; Hideyuki Ito; Teruo Mukainaka; Hiroshi Higashihara; Fumio Enjo; Harukuni Tokuda; Hoyoku Nishino; Takashi Yoshida
Ichthyotoxic and anticarcinogenic effects of triterpenoids from Sandoricum koetjape bark.
Biological & pharmaceutical bulletin 2003;26(9):1351-3.
2003: Ignacio A Jiménez; Isabel L Bazzocchi; Marvin J Núñez; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Takao Konoshima; Angel G Ravelo
Absolute configuration of sesquiterpenes from Crossopetalum tonduzii and their inhibitory effects on Epstein-Barr virus early antigen activation in Raji cells.
Journal of natural products 2003;66(8):1047-50.
2003: Midori Takasaki; Takao Konoshima; Yuji Murata; Masaki Sugiura; Hoyoku Nishino; Harukuni Tokuda; Kazuhiro Matsumoto; Ryoji Kasai; Kazuo Yamasaki
Anticarcinogenic activity of natural sweeteners, cucurbitane glycosides, from Momordica grosvenori.
Cancer letters 2003;198(1):37-42.
2003: Masashi Kuchide; Harukuni Tokuda; Junko Takayasu; Fumio Enjo; Takeshi Ishikawa; Eiichiro Ichiishi; Yuji Naito; Norimasa Yoshida; Toshikazu Yoshikawa; Hoyoku Nishino
Cancer chemopreventive effects of oral feeding alpha-tocopherol on ultraviolet light B induced photocarcinogenesis of hairless mouse.
Cancer letters 2003;196(2):169-77.
2003: Reiko Tanaka; Toshifumi Minami; Yohei Ishikawa; Shunyo Matsunaga; Harukuni Tokuda; Hoyoku Nishino
Cancer chemopreventive activity of serratane-type triterpenoids on two-stage mouse skin carcinogenesis.
Cancer letters 2003;196(2):121-6.
2003: Yoshiko Satomi; Ping Bu; Masato Okuda; Harukuni Tokuda; Hoyoku Nishino
H-ras mutations at codon 61 or 13 in tumors initiated with a NO donor in mouse skin.
Cancer letters 2003;196(1):17-22.
2003: Kazuhide Konishi; Akira Iida; Masafumi Kaneko; Kiyoshi Tomioka; Harukuni Tokuda; Hoyoku Nishino; Yuko Kumeda
Cancer preventive potential of trichothecenes from Trichothecium roseum.
Bioorganic & medicinal chemistry 2003;11(12):2511-8.
2003: Motohiko Ukiya; Toshihiro Akihisa; Harukuni Tokuda; Kazuo Koike; Junko Takayasu; Hiroki Okuda; Yumiko Kimura; Tamotsu Nikaido; Hoyoku Nishino
Isolation, structural elucidation, and inhibitory effects of terpenoid and lipid constituents from sunflower pollen on Epstein-Barr virus early antigen induced by tumor promoter, TPA.
Journal of agricultural and food chemistry 2003;51(10):2949-57.
2003: Masataka Itoigawa; Chihiro Ito; Tian-Shung Wu; Fumio Enjo; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Cancer chemopreventive activity of acridone alkaloids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Cancer letters 2003;193(2):133-8.
2003: Adelheid Brantner; Kaleab Asres; Asima Chakraborty; Harukuni Tokuda; XY Mou; Teruo Mukainaka; Hoyoku Nishino; Stefka Stoyanova; M Hamburger
Crown gall -- a plant tumour with biological activities.
Phytotherapy research : PTR 2003;17(4):385-90.
2003: Sadaaki Tamura; Narihiko Fukamiya; Masayoshi Okano; Junko Koyama; Kazuo Koike; Harukuni Tokuda; Wataru Aoi; Junko Takayasu; Masashi Kuchide; Hoyoku Nishino
Three new quassinoids, ailantinol E, F, and G, from Ailanthus altissima.
Chemical & pharmaceutical bulletin 2003;51(4):385-9.
2003: Nobuko Sakurai; Mutsuo Kozuka; Harukuni Tokuda; Yoshitaka Nobukuni; Junko Takayasu; Hoyoku Nishino; Akiko Kusano; Genjiro Kusano; Masahiro Nagai; Yojiro Sakurai; Kuo-Hsiung Lee
Antitumor agents 220. Antitumor-promoting effects of cimigenol and related compounds on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Bioorganic & medicinal chemistry 2003;11(6):1137-40.
2003: Diego Colombo; Fiamma Ronchetti; Antonio Scala; Lucio Toma; Harukuni Tokuda; Hoyoku Nishino
Synthesis and anti-tumor-promoting activity of glycoglycerolipid analogues lacking the glycerol backbone.
Bioorganic & medicinal chemistry 2003;11(6):909-12.
2003: Chihiro Ito; Masataka Itoigawa; Yoshitaka Mishina; Valdir Cechinel Filho; Fumio Enjo; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Chemical constituents of Calophyllum brasiliense. 2. Structure of three new coumarins and cancer chemopreventive activity of 4-substituted coumarins.
Journal of natural products 2003;66(3):368-71.
2003: Takeshi Ishikawa; Norimasa Yoshida; Harukuni Tokuda; Eiichiro Ichiishi; Masashi Kuchide; Satoshi Kokura; Yuji Naito; Shinya Toyokuni; Hoyoku Nishino; Toshikazu Yoshikawa
Tumor initiating activity of Helicobacter pylori water extract on mouse skin carcinogenesis.
Cancer letters 2003;191(1):41-7.
2003: Wataru Aoi; Yuji Naito; Kunihiro Sakuma; Masashi Kuchide; Harukuni Tokuda; Takashi Maoka; Shinya Toyokuni; Shigenori Oka; Masahiro Yasuhara; Toshikazu Yoshikawa
Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice.
Antioxidants & redox signaling 2003;5(1):139-44.
2003: Chihiro Ito; Masataka Itoigawa; Yoshiaki Miyamoto; Saori Onoda; K Sundar Rao; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Polyprenylated benzophenones from Garcinia assigu and their potential cancer chemopreventive activities.
Journal of natural products 2003;66(2):206-9.
2003: Chihiro Ito; Masataka Itoigawa; Tomoko Takakura; Nijsiri Ruangrungsi; Fumio Enjo; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Chemical constituents of Garcinia fusca: structure elucidation of eight new xanthones and their cancer chemopreventive activity.
Journal of natural products 2003;66(2):200-5.
2003: Toshiyuki Fukuda; Hideyuki Ito; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Takashi Yoshida
Anti-tumor promoting effect of glycosides from Prunus persica seeds.
Biological & pharmaceutical bulletin 2003;26(2):271-3.
2003: Govind J Kapadia; Magnus A Azuine; Rajagopalan Sridhar; Yoko Okuda; Atsushi Tsuruta; Eiichiro Ichiishi; Teruo Mukainake; Midori Takasaki; Takao Konoshima; Hoyoku Nishino; Harukuni Tokuda
Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot.
Pharmacological research : the official journal of the Italian Pharmacological Society 2003;47(2):141-8.
2003: Manabu Iwamoto; Toshifumi Minami; Harukuni Tokuda; Hironori Ohtsu; Reiko Tanaka
Potential antitumor promoting diterpenoids from the stem bark of Thuja standishii.
Planta medica 2003;69(1):69-72.
2002: Toshifumi Minami; Shun-ichi Wada; Harukuni Tokuda; Genzoh Tanabe; Osamu Muraoka; Reiko Tanaka
Potential antitumor-promoting diterpenes from the cones of Pinus luchuensis.
Journal of natural products 2002;65(12):1921-3.
2002: Diego Colombo; Federica Compostella; Fiamma Ronchetti; Shahrzad Reza-Elahi; Antonio Scala; Lucio Toma; Wataru Aoi; Masashi Kuchide; Junko Takayasu; Harukuni Tokuda; Hoyoku Nishino
Inhibitory effect of stabilized analogues of glycoglycerolipids on Epstein-Barr virus activation and mouse skin tumor promotion.
Cancer letters 2002;186(1):37-41.
2002: Sadaaki Tamura; Narihiko Fukamiya; Masayoshi Okano; Harukuni Tokuda; Wataru Aoi; Teruo Mukainaka; Hoyoku Nishino; Kiyoshi Tagahara; Kazuo Koike
Cancer chemopreventive effect of quassinoid derivatives. Introduction of side chain to shinjulactone C for enhancement of inhibitory effect on Epstein-Barr virus activation.
Cancer letters 2002;185(1):47-51.
2002: Motohiko Ukiya; Toshihiro Akihisa; Harukuni Tokuda; Masakazu Toriumi; Teruo Mukainaka; Norihiro Banno; Yumiko Kimura; Jun-Ichi Hasegawa; Hoyoku Nishino
Inhibitory effects of cucurbitane glycosides and other triterpenoids from the fruit of Momordica grosvenori on epstein-barr virus early antigen induced by tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Journal of agricultural and food chemistry 2002;50(23):6710-5.
2002: Junko Ishida; Mutsuo Kozuka; Harukuni Tokuda; Hoyoku Nishino; Seiji Nagumo; Kuo-Hsiung Lee; Masahiro Nagai
Chemopreventive potential of cyclic diarylheptanoids.
Bioorganic & medicinal chemistry 2002;10(10):3361-5.
2002: Dao-Feng Chen; Shun-Xiang Zhang; Mutsuo Kozuka; Quan-Zhong Sun; Ju Feng; Qiang Wang; Teruo Mukainaka; Yoshitaka Nobukuni; Harukuni Tokuda; Hoyoku Nishino; Hui-Kang Wang; Susan L Morris-Natschke; Kuo-Hsiung Lee
Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation.
Journal of natural products 2002;65(9):1242-5.
2002: Junko Koyama; Izumi Morita; Kiyoshi Tagahara; Yoshitaka Nobukuni; Teruo Mukainaka; Masashi Kuchide; Harukuni Tokuda; Hoyoku Nishino
Chemopreventive effects of emodin and cassiamin B in mouse skin carcinogenesis.
Cancer letters 2002;182(2):135-9.
2002: Govind J Kapadia; Magnus A Azuine; Harukuni Tokuda; Midori Takasaki; Teruo Mukainaka; Takao Konoshima; Hoyoku Nishino
Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis.
Pharmacological research : the official journal of the Italian Pharmacological Society 2002;45(6):499-505.
2002: Eliane S Nakamura; Fumiya Kurosaki; Munehisa Arisawa; Teruo Mukainaka; Junko Takayasu; Masato Okuda; Harukuni Tokuda; Hoyoku Nishino; Floriano Pastore
Cancer chemopreventive effects of a Brazilian folk medicine, Juca, on in vivo two-stage skin carcinogenesis.
Journal of ethnopharmacology 2002;81(1):135-7.
2002: Hideyuki Ito; Eri Kobayashi; Shu-Hua Li; Tsutomu Hatano; Daigo Sugita; Naoki Kubo; Susumu Shimura; Yoshio Itoh; Harukuni Tokuda; Hoyoku Nishino; Takashi Yoshida
Antitumor activity of compounds isolated from leaves of Eriobotrya japonica.
Journal of agricultural and food chemistry 2002;50(8):2400-3.
2002: Motohiko Ukiya; Toshihiro Akihisa; Harukuni Tokuda; Masaya Hirano; Manabu Oshikubo; Yoshitoshi Nobukuni; Yumiko Kimura; Takaaki Tai; Seizo Kondo; Hoyoku Nishino
Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.
Journal of natural products 2002;65(4):462-5.
2002: Eliane S Nakamura; Fumiya Kurosaki; Munehisa Arisawa; Teruo Mukainaka; Masato Okuda; Harukuni Tokuda; Hoyoku Nishino; Floriano Pastore
Cancer chemopreventive effects of constituents of Caesalpinia ferrea and related compounds.
Cancer letters 2002;177(2):119-24.
2002: Motohiko Ukiya; Toshihiro Akihisa; Harukuni Tokuda; Hiroyuki Suzuki; Teruo Mukainaka; Eiichiro Ichiishi; Ken Yasukawa; Yoshimasa Kasahara; Hoyoku Nishino
Constituents of Compositae plants III. Anti-tumor promoting effects and cytotoxic activity against human cancer cell lines of triterpene diols and triols from edible chrysanthemum flowers.
Cancer letters 2002;177(1):7-12.
2002: Asima Chakraborty; Adelheid Brantner; Teruo Mukainaka; Yoshitaka Nobukuni; Masashi Kuchide; Takao Konoshima; Harukuni Tokuda; Hoyoku Nishino
Cancer chemopreventive activity of Achyranthes aspera leaves on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Cancer letters 2002;177(1):1-5.
2002: Toshihiro Akihisa; Yoshio Takamine; Kazuo Yoshizumi; Harukuni Tokuda; Yumiko Kimura; Motohiko Ukiya; Toro Nakahara; Toshihiro Yokochi; Eiichiro Ichiishi; Hoyoku Nishino
Microbial transformations of two lupane-type triterpenes and anti-tumor-promoting effects of the transformation products.
Journal of natural products 2002;65(3):278-82.
2002: Chihiro Ito; Masataka Itoigawa; Yoshitaka Mishina; Valdir Cechinel Filho; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Chemical constituents of Calophyllum brasiliensis: structure elucidation of seven new xanthones and their cancer chemopreventive activity.
Journal of natural products 2002;65(3):267-72.
2002: Govind J Kapadia; Magnus A Azuine; Harukuni Tokuda; Eric Hang; Teruo Mukainaka; Hoyoku Nishino; Rajagopalan Sridhar
Inhibitory effect of herbal remedies on 12-O-tetradecanoylphorbol-13-acetate-promoted Epstein-Barr virus early antigen activation.
Pharmacological research : the official journal of the Italian Pharmacological Society 2002;45(3):213-20.
2002: Masataka Itoigawa; Chihiro Ito; Motoharu Ju-ichi; Toshihiro Nobukuni; Eiichiro Ichiishi; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Cancer chemopreventive activity of flavanones on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Cancer letters 2002;176(1):25-9.
2002: Motohiko Ukiya; Toshihiro Akihisa; Ken Yasukawa; Harukuni Tokuda; Masakazu Toriumi; Kazuo Koike; Yumiko Kimura; Tamotsu Nikaido; Wataru Aoi; Hoyoku Nishino; Michio Takido
Anti-inflammatory and anti-tumor-promoting effects of cucurbitane glycosides from the roots of Bryonia dioica.
Journal of natural products 2002;65(2):179-83.
2002: Toshihiro Akihisa; E M Kithsiri Wijeratne; Harukuni Tokuda; Fumio Enjo; Masakazu Toriumi; Yumiko Kimura; Kazuo Koike; Tamotsu Nikaido; Yasuhiro Tezuka; Hoyoku Nishino
Eupha-7,9(11),24-trien-3beta-ol ("antiquol C") and other triterpenes from Euphorbia antiquorum latex and their inhibitory effects on Epstein-Barr virus activation.
Journal of natural products 2002;65(2):158-62.
2002: Masaki Baba; Yongri Jin; Atsuo Mizuno; Hisaya Suzuki; Yoshihito Okada; Nobuo Takasuka; Harukuni Tokuda; Hoyoku Nishino; Toru Okuyama
Studies on cancer chemoprevention by traditional folk medicines XXIV. Inhibitory effect of a coumarin derivative, 7-isopentenyloxycoumarin, against tumor-promotion.
Biological & pharmaceutical bulletin 2002;25(2):244-6.
2002: Shoko Taniguchi; Yoko Imayoshi; Eri Kobayashi; Yoshie Takamatsu; Hideyuki Ito; Tsutomu Hatano; Hiroshi Sakagami; Harukuni Tokuda; Hoyoku Nishino; Daigo Sugita; Susumu Shimura; Takashi Yoshida
Production of bioactive triterpenes by Eriobotrya japonica calli.
Phytochemistry 2002;59(3):315-23.
2001: Masataka Itoigawa; Chihiro Ito; Hugh T-W Tan; M Okuda; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Cancer chemopreventive activity of naphthoquinones and their analogs from Avicennia plants.
Cancer letters 2001;174(2):135-9.
2001: Takao Konoshima; Tenji Konishi; Midori Takasaki; Kiyonori Yamazoe; Harukuni Tokuda
Anti-tumor-promoting activity of the diterpene from Excoecaria agallocha. II.
Biological & pharmaceutical bulletin 2001;24(12):1440-2.
2001: Hoyoku Nishino; Harukuni Tokuda; Tsunehiro Ii; M Takemura; Masashi Kuchide; M Kanazawa; Xiao Yang Mou; Ping Bu; Junko Takayasu; Mari Onozuka; Mitsuharu Masuda; Yoshiko Satomi; Takao Konoshima; N Kishi; Masaki Baba; Y Okada; T Okuyama
Cancer chemoprevention by ginseng in mouse liver and other organs.
Journal of Korean medical science 2001;16 Suppl():S66-9.
2001: Y Iwase; Yuko Takemura; Motoharu Ju-ichi; Teruo Mukainaka; Eiichiro Ichiishi; Chihiro Ito; Hiroshi Furukawa; Masamichi Yano; Harukuni Tokuda; Hoyoku Nishino
Inhibitory effect of flavonoid derivatives on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors.
Cancer letters 2001;173(2):105-9.
2001: Toshihiro Akihisa; Harukuni Tokuda; Eiichiro Ichiishi; Teruo Mukainaka; Masakazu Toriumi; Motohiko Ukiya; Ken Yasukawa; Hoyoku Nishino
Anti-tumor promoting effects of multiflorane-type triterpenoids and cytotoxic activity of karounidiol against human cancer cell lines.
Cancer letters 2001;173(1):9-14.
2001: A Inad; Hoyoku Nishino; Masashi Kuchide; Junko Takayasu; Teruo Mukainaka; Yoshitaka Nobukuni; M Okuda; Harukuni Tokuda
Cancer chemopreventive activity of odorine and odorinol from Aglaia odorata.
Biological & pharmaceutical bulletin 2001;24(11):1282-5.
2001: Reiko Tanaka; Toshifumi Minami; K Tsujimoto; Shunyo Matsunaga; Harukuni Tokuda; Hoyoku Nishino; Y Terada; Akira Yoshitake
Cancer chemopreventive agents, serratane-type triterpenoids from Picea jezoensis.
Cancer letters 2001;172(2):119-26.
2001: Takashi Maoka; K Mochida; Mutsuo Kozuka; Y Ito; Yasuhiro Fujiwara; Keiji Hashimoto; Fumio Enjo; M Ogata; Yoshitaka Nobukuni; Harukuni Tokuda; Hoyoku Nishino
Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L.
Cancer letters 2001;172(2):103-9.
2001: Junko Koyama; Izumi Morita; Kiyoshi Tagahara; M Ogata; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino
Inhibitory effects of anthraquinones and bianthraquinones on Epstein-Barr virus activation.
Cancer letters 2001;170(1):15-8.
2001: Masataka Itoigawa; Chihiro Ito; Hugh T-W Tan; M Kuchide; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum.
Cancer letters 2001;169(1):15-9.
2001: Diego Colombo; Federica Compostella; Fiamma Ronchetti; Antonio Scala; Harukuni Tokuda; Hoyoku Nishino
Diesters of glycosylglycerols active in cancer chemoprevention.
European journal of medicinal chemistry 2001;36(7-8):691-5.
2001: Manabu Iwamoto; Hironori Ohtsu; Harukuni Tokuda; Hoyoku Nishino; Shunyo Matsunaga; Reiko Tanaka
Anti-tumor promoting diterpenes from the stem bark of Thuja standishii (Cupressaceae).
Bioorganic & medicinal chemistry 2001;9(7):1911-21.
2001: Shinichi Uesato; Y Kitagawa; T Kaijima; Harukuni Tokuda; M Okuda; XY Mou; Teruo Mukainaka; Hoyoku Nishino
Inhibitory effects of 6-O-acylated L-ascorbic acids possessing a straight- or branched-acyl chain on Epstein-Barr virus activation.
Cancer letters 2001;166(2):143-6.
2001: Y Iwase; Yuko Takemura; Motoharu Ju-ichi; Masamichi Yano; Chihiro Ito; Hiroshi Furukawa; Teruo Mukainaka; Masashi Kuchide; Harukuni Tokuda; Hoyoku Nishino
Cancer chemopreventive activity of 3,5,6,7,8,3',4'-heptamethoxyflavone from the peel of citrus plants.
Cancer letters 2001;163(1):7-9.
2001: Chihiro Ito; Masataka Itoigawa; Yoshitaka Mishina; H Tomiyasu; M Litaudon; J P Cosson; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Cancer chemopreventive agents. New depsidones from Garcinia plants.
Journal of natural products 2001;64(2):147-50.
2001: Hironori Ohtsu; R Tanak; Yasuko In; Shunyo Matsunaga; Harukuni Tokuda; Hoyoku Nishino
Abietane diterpenoids from the cones of Larix kaempferi and their inhibitory effects on Epstein-Barr virus activation.
Planta medica 2001;67(1):55-60.
2000: Govind J Kapadia; Magnus A Azuine; Junko Takayasu; Takao Konoshima; Midori Takasaki; Hoyoku Nishino; Harukuni Tokuda
Inhibition of epstein-barr virus early antigen activation promoted by 12-O-tetradecanoylphorbol-13-acetate by the non-steroidal anti-inflammatory drugs.
Cancer letters 2000;161(2):221-9.
2000: Diego Colombo; Federica Compostella; Fiamma Ronchetti; Antonio Scala; Lucio Toma; Masashi Kuchide; Harukuni Tokuda; Hoyoku Nishino
Anti-tumor-promoting effects of glycoglycerolipid analogues on two-stage mouse skin carcinogenesis.
Cancer letters 2000;161(2):201-5.
2000: Reiko Tanaka; Hironori Ohtsu; Manabu Iwamoto; Toshifumi Minami; Harukuni Tokuda; Hoyoku Nishino; Shunyo Matsunaga; Akira Yoshitake
Cancer chemopreventive agents, labdane diterpenoids from the stem bark of Thuja standishii (Gord.) Carr.
Cancer letters 2000;161(2):165-70.
2000: Diego Colombo; Federica Compostella; Fiamma Ronchetti; Antonio Scala; Lucio Toma; Harukuni Tokuda; Hoyoku Nishino
Glycoglycerolipid analogues active as anti-tumor-promoters: the influence of the anomeric configuration.
European journal of medicinal chemistry 2000;35(12):1109-13.
2000: J Ishida; Mutsuo Kozuka; H Wang; Takao Konoshima; Harukuni Tokuda; M Okuda; X Yang Mou; Hoyoku Nishino; Nobuko Sakurai; Kuo-Hsiung Lee; Masahiro Nagai
Antitumor-promoting effects of cyclic diarylheptanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Cancer letters 2000;159(2):135-40.
2000: Reiko Tanaka; Y Kinouchi; Harukuni Tokuda; Hoyoku Nishino; Shunyo Matsunaga
Bioactive triterpenoids from the stem bark of Picea glehni.
Planta medica 2000;66(7):630-4.
2000: Chihiro Ito; Masataka Itoigawa; T Otsuka; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Constituents of Boronia pinnata.
Journal of natural products 2000;63(10):1344-8.
2000: Hideyuki Ito; M Koreishi; Harukuni Tokuda; Hoyoku Nishino; Takashi Yoshida
Cypellocarpins A-C, phenol glycosides esterified with oleuropeic acid, from Eucalyptus cypellocarpa.
Journal of natural products 2000;63(9):1253-7.
2000: Chihiro Ito; Masataka Itoigawa; S Katsuno; M Omura; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
Chemical constituents of Clausena excavata: isolation and structure elucidation of novel furanone-coumarins with inhibitory effects for tumor-promotion.
Journal of natural products 2000;63(9):1218-24.
2000: Shinichi Uesato; Y Kitagawa; Yukihiko Hara; Harukuni Tokuda; M Okuda; XY Mou; Teruo Mukainaka; Hoyoku Nishino
Antitumor promoting activities of 3-O-acyl-(-)epigallocatechins.
Bioorganic & medicinal chemistry letters 2000;10(15):1673-5.
2000: Hideyuki Ito; T Muranaka; K Mori; Z X Jin; Harukuni Tokuda; Hoyoku Nishino; Takashi Yoshida
Ichthyotoxic phloroglucinol derivatives from Dryopteris fragrans and their anti-tumor promoting activity.
Chemical & pharmaceutical bulletin 2000;48(8):1190-5.
2000: Antonio G González; Benigna M Tincusi; Isabel L Bazzocchi; Harukuni Tokuda; Hoyoku Nishino; Takao Konoshima; Ignacio A Jiménez; Angel G Ravelo
Anti-tumor promoting effects of sesquiterpenes from Maytenus cuzcoina (Celastraceae).
Bioorganic & medicinal chemistry 2000;8(7):1773-8.
2000: Y Kinouchi; H Ohtsu; Harukuni Tokuda; Hoyoku Nishino; Shunyo Matsunaga; Reiko Tanaka
Potential antitumor-promoting diterpenoids from the stem bark of Picea glehni.
Journal of natural products 2000;63(6):817-20.
2000: Sadaaki Tamura; Narihiko Fukamiya; XY Mou; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Kiyoshi Tagahara; Kazuo Koike; Kuo-Hsiung Lee; Masayoshi Okano
Conversion of quassinoids for enhancement of inhibitory effect against Epstein-Barr virus early antigen activation. Introduction of lipophilic side chain and esterification of diosphenol.
Chemical & pharmaceutical bulletin 2000;48(6):876-8.
2000: Y Iwase; Yuko Takemura; Motoharu Ju-ichi; Chihiro Ito; Hiroshi Furukawa; S Kawaii; Masamichi Yano; Xiao Yang Mou; Junko Takayasu; Harukuni Tokuda; Hoyoku Nishino
Inhibitory effect of flavonoids from citrus plants on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors.
Cancer letters 2000;154(1):101-5.
2000: Chihiro Ito; Masataka Itoigawa; Hugh T-W Tan; Harukuni Tokuda; X Yang Mou; Teruo Mukainaka; T Ishikawa; Hoyoku Nishino; Hiroshi Furukawa
Anti-tumor-promoting effects of isoflavonoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Cancer letters 2000;152(2):187-92.
2000: Reiko Tanaka; H Aoki; T Mizota; Shun-ichi Wada; Shunyo Matsunaga; Harukuni Tokuda; Hoyoku Nishino
Three new lanostane-type triterpene lactones from the stem bark of Abies mariesii.
Planta medica 2000;66(2):163-8.
2000: Hoyoku Nishino; Harukuni Tokuda; Michiaki Murakoshi; Yoshiko Satomi; Mitsuharu Masuda; Mari Onozuka; S Yamaguchi; Junko Takayasu; J Tsuruta; M Okuda; F Khachik; Tomio Narisawa; Nobuo Takasuka; Masamichi Yano
Cancer prevention by natural carotenoids.
BioFactors (Oxford, England) 2000;13(1-4):89-94.
2000: Chihiro Ito; S Katsuno; Masataka Itoigawa; Nijsiri Ruangrungsi; Teruo Mukainaka; M Okuda; Y Kitagawa; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
New carbazole alkaloids from Clausena anisata with antitumor promoting activity.
Journal of natural products 2000;63(1):125-8.
2000: Reiko Tanaka; K Kasubuchi; S Kita; Harukuni Tokuda; Hoyoku Nishino; Shunyo Matsunaga
Bioactive steroids from the whole herb of Euphorbia chamaesyce.
Journal of natural products 2000;63(1):99-103.
1999: Takao Konoshima; Midori Takasaki; Eiichiro Ichiishi; T Murakami; Harukuni Tokuda; Hoyoku Nishino; N M Duc; Ryoji Kasai; Kazuo Yamasaki
Cancer chemopreventive activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis.
Cancer letters 1999;147(1-2):11-6.
1999: Chihiro Ito; Masataka Itoigawa; Y Miyamoto; K S Rao; Junko Takayasu; Y Okuda; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Hiroshi Furukawa
A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity.
Journal of natural products 1999;62(12):1668-71.
1999: Takao Konoshima; Midori Takasaki; Harukuni Tokuda
Anti-carcinogenic activity of the roots of Panax notoginseng. II.
Biological & pharmaceutical bulletin 1999;22(10):1150-2.
1999: Hoyoku Nishino; Michiaki Murakoshi; Mitsuharu Masuda; Harukuni Tokuda; Yoshiko Satomi; Mari Onozuka; S Yamaguchi; Ping Bu; A Tsuruta; Kazuto Nosaka; Masaki Baba; Nobuo Takasuka
Suppression of lung and liver carcinogenesis in mice by oral administration of myo-inositol.
Anticancer research 1999;19(5A):3663-4.
1999: Diego Colombo; Federica Compostella; Fiamma Ronchetti; Antonio Scala; Lucio Toma; Harukuni Tokuda; Hoyoku Nishino
Chemoenzymatic synthesis and antitumor promoting activity of 6'- and 3-esters of 2-O-beta-D-glucosylglycerol.
Bioorganic & medicinal chemistry 1999;7(9):1867-71.
1999: Hideyuki Ito; M Miyake; Eisei Nishitani; K Mori; Tsutomu Hatano; T Okuda; Takao Konoshima; Midori Takasaki; Mutsuo Kozuka; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Takashi Yoshida
Anti-tumor promoting activity of polyphenols from Cowania mexicana and Coleogyne ramosissima.
Cancer letters 1999;143(1):5-13.
1999: Diego Colombo; Federica Compostella; Fiamma Ronchetti; Antonio Scala; Lucio Toma; Teruo Mukainaka; Akito Nagatsu; Takao Konoshima; Harukuni Tokuda; Hoyoku Nishino
Inhibitory effects of monoacylated 2-O-beta-galactosylglycerols on Epstein-Barr virus activation: the significant role of the hexanoyl chain.
Cancer letters 1999;143(1):1-4.
1999: Chihiro Ito; Masataka Itoigawa; Hiroshi Furukawa; Eiichiro Ichiishi; Teruo Mukainaka; M Okuda; M Ogata; Harukuni Tokuda; Hoyoku Nishino
Anti-tumor-promoting effects of phenylpropanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Cancer letters 1999;142(1):49-54.
1999: Midori Takasaki; Harukuni Tokuda; Hoyoku Nishino; Takao Konoshima
Cancer chemopreventive agents (antitumor-promoters) from Ajuga decumbens.
Journal of natural products 1999;62(7):972-5.
1999: Midori Takasaki; Takao Konoshima; Harukuni Tokuda; Kazuo Masuda; Yoko Arai; Kenji Shiojima; Hiroyuki Ageta
Anti-carcinogenic activity of Taraxacum plant. II.
Biological & pharmaceutical bulletin 1999;22(6):606-10.
1999: Midori Takasaki; Takao Konoshima; Harukuni Tokuda; Kazuo Masuda; Yoko Arai; Kenji Shiojima; Hiroyuki Ageta
Anti-carcinogenic activity of Taraxacum plant. I.
Biological & pharmaceutical bulletin 1999;22(6):602-5.
1999: Y Iwase; Yuko Takemura; Motoharu Ju-ichi; S Kawaii; Masamichi Yano; Y Okuda; Teruo Mukainaka; A Tsuruta; M Okuda; Junko Takayasu; Harukuni Tokuda; Hoyoku Nishino
Inhibitory effect of Epstein-Barr virus activation by Citrus fruits, a cancer chemopreventor.
Cancer letters 1999;139(2):227-36.
1999: Chihiro Ito; Masataka Itoigawa; Hiroshi Furukawa; Harukuni Tokuda; Y Okuda; Teruo Mukainaka; M Okuda; Hoyoku Nishino
Anti-tumor-promoting effects of 8-substituted 7-methoxycoumarins on Epstein-Barr virus activation assay.
Cancer letters 1999;138(1-2):87-92.
1998: Chihiro Ito; Masataka Itoigawa; Hiroshi Furukawa; K S Rao; Fumio Enjo; Ping Bu; Junko Takayasu; Harukuni Tokuda; Hoyoku Nishino
Xanthones as inhibitors of Epstein-Barr virus activation.
Cancer letters 1998;132(1-2):113-7.
1998: Tenji Konishi; Midori Takasaki; Harukuni Tokuda; Shiu Kiyosawa; Takao Konoshima
Anti-tumor-promoting activity of diterpenes from Excoecaria agallocha.
Biological & pharmaceutical bulletin 1998;21(9):993-6.
1998: Takao Konoshima; Midori Takasaki; Harukuni Tokuda; Hoyoku Nishino; N M Duc; Ryoji Kasai; Kazuo Yamasaki
Anti-tumor-promoting activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. (I).
Biological & pharmaceutical bulletin 1998;21(8):834-8.
1998: Govind J Kapadia; Harukuni Tokuda; Rajagopalan Sridhar; V Balasubramanian; Junko Takayasu; Ping Bu; Fumio Enjo; Midori Takasaki; Takao Konoshima; Hoyoku Nishino
Cancer chemopreventive activity of synthetic colorants used in foods, pharmaceuticals and cosmetic preparations.
Cancer letters 1998;129(1):87-95.
1998: A Fujiwara; T Mori; A Iida; S Ueda; Y Hano; T Nomura; Harukuni Tokuda; Hoyoku Nishino
Antitumor-promoting naphthoquinones from Catalpa ovata.
Journal of natural products 1998;61(5):629-32.
1998: Diego Colombo; Antonio Scala; I M Taino; Lucio Toma; Fiamma Ronchetti; Harukuni Tokuda; Hoyoku Nishino; Akito Nagatsu; Jinsaku Sakakibara
Inhibitory effects of fatty acid monoesters of 2-O-beta-D-glucosylglycerol on Epstein-Barr virus activation.
Cancer letters 1998;123(1):83-6.
1997: Takao Konoshima; Midori Takasaki; Mutsuo Kozuka; Harukuni Tokuda; Hoyoku Nishino; E Matsuda; M Nagai
Anti-tumor promoting activities of isoflavonoids from Wistaria brachybotrys.
Biological & pharmaceutical bulletin 1997;20(8):865-8.
1997: Midori Takasaki; Takao Konoshima; I Yasuda; T Hamano; Harukuni Tokuda
Inhibitory effects of shouseiryu-to on two-stage carcinogenesis. II. Anti-tumor-promoting activities of lignans from Asiasarum heterotropoides var. mandshuricum.
Biological & pharmaceutical bulletin 1997;20(7):776-80.
1997: Junko Koyama; Kiyoshi Tagahara; Toshiyuki Osakai; Yoshio Tsujino; S Tsurumi; Hoyoku Nishino; Harukuni Tokuda
Inhibitory effects on Epstein-Barr virus activation of anthraquinones: correlation with redox potentials.
Cancer letters 1997;115(2):179-83.
1997: Govind J Kapadia; V Balasubramanian; Harukuni Tokuda; A Iwashima; Hoyoku Nishino
Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation by natural colorants.
Cancer letters 1997;115(2):173-8.
1997: S Rahman; Narihiko Fukamiya; N Ohno; Harukuni Tokuda; Hoyoku Nishino; Kiyoshi Tagahara; Kuo-Hsiung Lee; Masayoshi Okano
Inhibitory effects of quassinoid derivatives on Epstein-Barr virus early antigen activation.
Chemical & pharmaceutical bulletin 1997;45(4):675-7.
1997: K Kubota; Narihiko Fukamiya; Harukuni Tokuda; Hoyoku Nishino; Kiyoshi Tagahara; Kuo-Hsiung Lee; Masayoshi Okano
Quassinoids as inhibitors of Epstein-Barr virus early antigen activation.
Cancer letters 1997;113(1-2):165-8.
1997: Govind J Kapadia; V Balasubramanian; Harukuni Tokuda; Takao Konoshima; Midori Takasaki; J Koyama; K Tagahaya; Hoyoku Nishino
Anti-tumor promoting effects of naphthoquinone derivatives on short term Epstein-Barr early antigen activation assay and in mouse skin carcinogenesis.
Cancer letters 1997;113(1-2):47-53.
1996: Govind J Kapadia; Harukuni Tokuda; Takao Konoshima; Midori Takasaki; Junko Takayasu; H Nishino
Anti-tumor promoting activity of Dryopteris phlorophenone derivatives.
Cancer letters 1996;105(2):161-5.
1996: Takao Konoshima; Midori Takasaki; Harukuni Tokuda; Kazuo Masuda; Yoko Arai; Kenji Shiojima; Hiroyuki Ageta
Anti-tumor-promoting activities of triterpenoids from ferns. I.
Biological & pharmaceutical bulletin 1996;19(7):962-5.
1996: H Shirahashi; T Morimoto; Akito Nagatsu; N Murakami; K Tatta; Jinsaku Sakakibara; Harukuni Tokuda; H Nishino
Antitumor-promoting activities of various synthetic 1-O-acyl-3-O-(6'-O-acyl-beta-D-galactopyranosyl)-sn-glycerols related to natural product from freshwater cyanobacterium Anabaena flos-aquae f. flos-aquae.
Chemical & pharmaceutical bulletin 1996;44(7):1404-6.
1996: Harukuni Tokuda; H Nishino; H Shirahashi; N Murakami; Akito Nagatsu; Jinsaku Sakakibara
Inhibition of 12-O-tetradecanoylphorbol-13-acetate promoted mouse skin papilloma by digalactosyl diacylglycerols from the fresh water cyanobacterium Phormidium tenue.
Cancer letters 1996;104(1):91-5.
1996: Govind J Kapadia; S C Sharma; Harukuni Tokuda; H Nishino; S Ueda
Inhibitory effect of iridoids on Epstein-Barr virus activation by a short-term in vitro assay for anti-tumor promoters.
Cancer letters 1996;102(1-2):223-6.
1996: Govind J Kapadia; Harukuni Tokuda; Takao Konoshima; H Nishino
Chemoprevention of lung and skin cancer by Beta vulgaris (beet) root extract.
Cancer letters 1996;100(1-2):211-4.
1995: T Morimoto; Akito Nagatsu; N Murakami; Jinsaku Sakakibara; Harukuni Tokuda; H Nishino; A Iwashima
Anti-tumour-promoting glyceroglycolipids from the green alga, Chlorella vulgaris.
Phytochemistry 1995;40(5):1433-7.
1995: Masayoshi Okano; Narihiko Fukamiya; Kiyoshi Tagahara; Harukuni Tokuda; A Iwashima; H Nishino; Kuo-Hsiung Lee
Inhibitory effects of quassinoids on Epstein-Barr virus activation.
Cancer letters 1995;94(2):139-46.
1995: Midori Takasaki; Takao Konoshima; Mutsuo Kozuka; Harukuni Tokuda
Anti-tumor-promoting activities of euglobals from Eucalyptus plants.
Biological & pharmaceutical bulletin 1995;18(3):435-8.
1995: Takao Konoshima; Midori Takasaki; Mutsuo Kozuka; T Nagao; H Okabe; N Irino; T Nakasumi; Harukuni Tokuda; H Nishino
Inhibitory effects of cucurbitane triterpenoids on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumor. II.
Biological & pharmaceutical bulletin 1995;18(2):284-7.
1994: Takao Konoshima; Midori Takasaki; T Tatsumoto; Mutsuo Kozuka; R Kasai; O Tanaka; R L Nie; Harukuni Tokuda; H Nishino; A Iwashima
Inhibitory effects of cucurbitane triterpenoids on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors.
Biological & pharmaceutical bulletin 1994;17(5):668-71.
1993: H Shirahashi; N Murakami; M Watanabe; Akito Nagatsu; Jinsaku Sakakibara; Harukuni Tokuda; H Nishino; A Iwashima
Isolation and identification of anti-tumor-promoting principles from the fresh-water cyanobacterium Phormidium tenue.
Chemical & pharmaceutical bulletin 1993;41(9):1664-6.
1993: Takao Konoshima; H Terada; M Kokumai; Mutsuo Kozuka; Harukuni Tokuda; J R Estes; L Li; Hui-Kang Wang; Kuo-Hsiung Lee
Studies on inhibitors of skin tumor promotion, XII. Rotenoids from Amorpha fruticosa.
Journal of natural products 1993;56(6):843-8.
1992: Michiaki Murakoshi; H Nishino; Harukuni Tokuda; A Iwashima; J Okuzumi; H Kitano; R Iwasaki
Inhibition by squalene of the tumor-promoting activity of 12-O-tetradecanoylphorbol-13-acetate in mouse-skin carcinogenesis.
International journal of cancer. Journal international du cancer 1992;52(6):950-2.
1992: Michiaki Murakoshi; H Nishino; Y Satomi; J Takayasu; T Hasegawa; Harukuni Tokuda; A Iwashima; J Okuzumi; H Okabe; H Kitano
Potent preventive action of alpha-carotene against carcinogenesis: spontaneous liver carcinogenesis and promoting stage of lung and skin carcinogenesis in mice are suppressed more effectively by alpha-carotene than by beta-carotene.
Cancer research 1992;52(23):6583-7.
1992: Takao Konoshima; M Kokumai; Mutsuo Kozuka; Harukuni Tokuda; H Nishino; A Iwashima
Anti-tumor-promoting activities of afromosin and soyasaponin I isolated from Wistaria brachybotrys.
Journal of natural products 1992;55(12):1776-8.
1992: H Nishino; M Tsushima; T Matsuno; Y Tanaka; J Okuzumi; Michiaki Murakoshi; Y Satomi; J Takayasu; Harukuni Tokuda; A Nishino
Anti-neoplastic effect of halocynthiaxanthin, a metabolite of fucoxanthin.
Anti-cancer drugs 1992;3(5):493-7.
1992: Takao Konoshima; M Kokumai; Mutsuo Kozuka; M Iinuma; M Mizuno; T Tanaka; Harukuni Tokuda; H Nishino; A Iwashima
Studies on inhibitors of skin tumor promotion. XI. Inhibitory effects of flavonoids from Scutellaria baicalensis on Epstein-Barr virus activation and their anti-tumor-promoting activities.
Chemical & pharmaceutical bulletin 1992;40(2):531-3.
1991: T Okuyama; M Takata; J Takayasu; T Hasegawa; Harukuni Tokuda; A Nishino; H Nishino; A Iwashima
Anti-tumor-promotion by principles obtained from Angelica keiskei.
Planta medica 1991;57(3):242-6.
1991: S Shibata; H Inoue; S Iwata; R D Ma; L J Yu; H Ueyama; J Takayasu; T Hasegawa; Harukuni Tokuda; A Nishino
Inhibitory effects of licochalcone A isolated from Glycyrrhiza inflata root on inflammatory ear edema and tumour promotion in mice.
Planta medica 1991;57(3):221-4.
1991: Takao Konoshima; Mutsuo Kozuka; Harukuni Tokuda; H Nishino; A Iwashima; M Haruna; K Ito; M Tanabe
Studies on inhibitors of skin tumor promotion, IX. Neolignans from Magnolia officinalis.
Journal of natural products 1991;54(3):816-22.
1990: Midori Takasaki; Takao Konoshima; K Fujitani; S Yoshida; H Nishimura; Harukuni Tokuda; H Nishino; A Iwashima; Mutsuo Kozuka
Inhibitors of skin-tumor promotion. VIII. Inhibitory effects of euglobals and their related compounds on Epstein-Barr virus activation. (1).
Chemical & pharmaceutical bulletin 1990;38(10):2737-9.
1990: J Takayasu; R Tanaka; S Matsunaga; H Ueyama; Harukuni Tokuda; T Hasegawa; A Nishino; H Nishino; A Iwashima
Anti-tumor-promoting activity of derivatives of abieslactone, a natural triterpenoid isolated from several Abies genus.
Cancer letters 1990;53(2-3):141-4.
1990: H Nishino; T Okuyama; M Takata; S Shibata; Harukuni Tokuda; J Takayasu; T Hasegawa; A Nishino; H Ueyama; A Iwashima
Studies on the anti-tumor-promoting activity of naturally occurring substances. IV. Pd-II [(+)anomalin, (+)praeruptorin B], a seselin-type coumarin, inhibits the promotion of skin tumor formation by 12-O-tetradecanoylphorbol-13-acetate in 7,12-dimethylbenz[a]anthracene-initiated mice.
Carcinogenesis 1990;11(9):1557-61.
1990: Midori Takasaki; Takao Konoshima; T Shingu; Harukuni Tokuda; H Nishino; A Iwashima; Mutsuo Kozuka
Structures of euglobal-G1, -G2, and -G3 from Eucalyptus grandis, three new inhibitors of Epstein-Barr virus activation.
Chemical & pharmaceutical bulletin 1990;38(5):1444-6.
1989: Takao Konoshima; Mutsuo Kozuka; J Koyama; T Okatani; K Tagahara; Harukuni Tokuda
Studies on inhibitors of skin tumor promotion, VI. Inhibitory effects of quinones on Epstein-Barr virus activation.
Journal of natural products 1989;52(5):987-95.
1988: Takao Konoshima; E Okamoto; Mutsuo Kozuka; H Nishino; Harukuni Tokuda; M Tanabe
Studies on inhibitors of skin tumor promotion, III. Inhibitory effects of isoflavonoids from Wisteria brachybotrys on Epstein-Barr virus activation.
Journal of natural products 1988;51(6):1266-70.
1987: Takao Konoshima; Midori Takasaki; Mutsuo Kozuka; Harukuni Tokuda
Studies on inhibitors of skin-tumor promotion, I. Inhibitory effects of triterpenes from Euptelea polyandra on Epstein-Barr virus activation.
Journal of natural products 1987;50(6):1167-70.