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Hajime Tokuda
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21
Matsuyama, Shin-ichi
8
Nishiyama, Ken-ichi
7
Narita, Shin-ichiro
5
Narita, Shin-Ichiro
5
Matsuyama, Shin-Ichi
4
Taniguchi, Naohiro
4
Yakushi, T
4
Yokota, N
3
Kanamaru, Kengo
3
Miyamoto, Shigehiko
3
Sugai, Rie
2
Nagamori, Shushi
1
Nagasawa, Hiromichi
1
Tanaka, Keiichi
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All Publications
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2009: Yasuda Masaki; Iguchi-Yokoyama Asako; Matsuyama Shin-ichi; Tokuda Hajime; Narita Shin-ichiro
Membrane topology and functional importance of the periplasmic region of ABC transporter LolCDE.
Bioscience, biotechnology, and biochemistry 2009;73(10):2310-6.
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2009: Tsukahara Jun; Narita Shin-Ichiro; Tokuda Hajime
Real time analysis of lipoprotein transfer from LolA to LolB by means of surface plasmon resonance.
FEBS letters 2009;583(18):2987-90.
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2009: Tsukahara Jun; Mukaiyama Keita; Okuda Suguru; Narita Shin-ichiro; Tokuda Hajime
Dissection of LolB function--lipoprotein binding, membrane targeting and incorporation of lipoproteins into lipid bilayers.
The FEBS journal 2009;276(16):4496-504.
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2009: Narita Shin-ichiro; Tokuda Hajime
Biochemical characterization of an ABC transporter LptBFGC complex required for the outer membrane sorting of lipopolysaccharides.
FEBS letters 2009;583(13):2160-4.
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2009: Okuda Suguru; Tokuda Hajime
Model of mouth-to-mouth transfer of bacterial lipoproteins through inner membrane LolC, periplasmic LolA, and outer membrane LolB.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(14):5877-82.
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2009: Tokuda Hajime
Biogenesis of outer membranes in Gram-negative bacteria.
Bioscience, biotechnology, and biochemistry 2009;73(3):465-73.
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2008: Watanabe Shoji; Oguchi Yuki; Takeda Kazuki; Miki Kunio; Tokuda Hajime
Introduction of a lethal redox switch that controls the opening and closing of the hydrophobic cavity in LolA.
The Journal of biological chemistry 2008;283(37):25421-7.
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2008: Oguchi Yuki; Takeda Kazuki; Watanabe Shoji; Yokota Naoko; Miki Kunio; Tokuda Hajime
Opening and closing of the hydrophobic cavity of LolA coupled to lipoprotein binding and release.
The Journal of biological chemistry 2008;283(37):25414-20.
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2008: Kawashima Yosuke; Miyazaki Emi; Müller Matthias; Tokuda Hajime; Nishiyama Ken-ichi
Diacylglycerol specifically blocks spontaneous integration of membrane proteins and allows detection of a factor-assisted integration.
The Journal of biological chemistry 2008;283(36):24489-96.
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2008: Okuda Suguru; Watanabe Shoji; Tokuda Hajime
A short helix in the C-terminal region of LolA is important for the specific membrane localization of lipoproteins.
FEBS letters 2008;582(15):2247-51.
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2008: Taniguchi Naohiro; Tokuda Hajime
Molecular events involved in a single cycle of ligand transfer from an ATP binding cassette transporter, LolCDE, to a molecular chaperone, LolA.
The Journal of biological chemistry 2008;283(13):8538-44.
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2007: Sugai Rie; Takemae Kazuhisa; Tokuda Hajime; Nishiyama Ken-ichi
Topology inversion of SecG is essential for cytosolic SecA-dependent stimulation of protein translocation.
The Journal of biological chemistry 2007;282(40):29540-8.
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2007: Miyamoto Shigehiko; Tokuda Hajime
Diverse effects of phospholipids on lipoprotein sorting and ATP hydrolysis by the ABC transporter LolCDE complex.
Biochimica et biophysica acta 2007;1768(7):1848-54.
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2007: Kanamaru Kyoko; Taniguchi Naohiro; Miyamoto Shigehiko; Narita Shin-ichiro; Tokuda Hajime
Complete reconstitution of an ATP-binding cassette transporter LolCDE complex from separately isolated subunits.
The FEBS journal 2007;274(12):3034-43.
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2007: Narita Shin-Ichiro; Tokuda Hajime
Amino acids at positions 3 and 4 determine the membrane specificity of Pseudomonas aeruginosa lipoproteins.
The Journal of biological chemistry 2007;282(18):13372-8.
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2007: Tanaka Shin-Ya; Narita Shin-Ichiro; Tokuda Hajime
Characterization of the Pseudomonas aeruginosa Lol system as a lipoprotein sorting mechanism.
The Journal of biological chemistry 2007;282(18):13379-84.
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2006: Ito Yasuko; Kanamaru Kyoko; Taniguchi Naohiro; Miyamoto Shigehiko; Tokuda Hajime
A novel ligand bound ABC transporter, LolCDE, provides insights into the molecular mechanisms underlying membrane detachment of bacterial lipoproteins.
Molecular microbiology 2006;62(4):1064-75.
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2006: Ito Yasuko; Matsuzawa Hitomi; Matsuyama Shin-ichi; Narita Shin-ichiro; Tokuda Hajime
Genetic analysis of the mode of interplay between an ATPase subunit and membrane subunits of the lipoprotein-releasing ATP-binding cassette transporter LolCDE.
Journal of bacteriology 2006;188(8):2856-64.
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2006: Watanabe Shoji; Matsuyama Shin-ichi; Tokuda Hajime
Roles of the hydrophobic cavity and lid of LolA in the lipoprotein transfer reaction in Escherichia coli.
The Journal of biological chemistry 2006;281(6):3335-42.
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2006: Narita Shin-ichiro; Tokuda Hajime
An ABC transporter mediating the membrane detachment of bacterial lipoproteins depending on their sorting signals.
FEBS letters 2006;580(4):1164-70.
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2005: Taniguchi Naohiro; Matsuyama Shin-Ichi; Tokuda Hajime
Mechanisms underlying energy-independent transfer of lipoproteins from LolA to LolB, which have similar unclosed {beta}-barrel structures.
The Journal of biological chemistry 2005;280(41):34481-8.
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2005: Ikegami Ayao; Nishiyama Ken-ichi; Matsuyama Shin-ichi; Tokuda Hajime
Disruption of rpmJ encoding ribosomal protein L36 decreases the expression of secY upstream of the spc operon and inhibits protein translocation in Escherichia coli.
Bioscience, biotechnology, and biochemistry 2005;69(8):1595-602.
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2005: Nishiyama Ken-ichi; Tokuda Hajime
Genes coding for SecG and Leu2-tRNA form an operon to give an unusual RNA comprising mRNA and a tRNA precursor.
Biochimica et biophysica acta 2005;1729(3):166-73.
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2004: Tokuda Hajime; Matsuyama Shin-ichi
Sorting of lipoproteins to the outer membrane in E. coli.
Biochimica et biophysica acta 2004;1694(1-3):IN1-9.
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2004: Wada Rieko; Matsuyama Shin-ichi; Tokuda Hajime
Targeted mutagenesis of five conserved tryptophan residues of LolB involved in membrane localization of Escherichia coli lipoproteins.
Biochemical and biophysical research communications 2004;323(3):1069-74.
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2004: Sugai Rie; Shimizu Hisayo; Nishiyama Ken-Ichi; Tokuda Hajime
Overexpression of gnsA, a multicopy suppressor of the secG null mutation, increases acidic phospholipid contents by inhibiting phosphatidylethanolamine synthesis at low temperatures.
Journal of bacteriology 2004;186(17):5968-71.
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2004: Miyadai Hidenori; Tanaka-Masuda Kimie; Matsuyama Shin-ichi; Tokuda Hajime
Effects of lipoprotein overproduction on the induction of DegP (HtrA) involved in quality control in the Escherichia coli periplasm.
The Journal of biological chemistry 2004;279(38):39807-13.
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2004: Narita Shin-Ichiro; Matsuyama Shin-Ichi; Tokuda Hajime
Lipoprotein trafficking in Escherichia coli.
Archives of microbiology 2004;182(1):1-6.
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2004: Tokuda Hajime; Matsuyama Shin-Ichi
Sorting of lipoproteins to the outer membrane in E. coli.
Biochimica et biophysica acta 2004;1693(1):5-13.
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2003: Hara Takashi; Matsuyama Shin-ichi; Tokuda Hajime
Mechanism underlying the inner membrane retention of Escherichia coli lipoproteins caused by Lol avoidance signals.
The Journal of biological chemistry 2003;278(41):40408-14.
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2003: Kato Yoshihisa; Nishiyama Ken-ichi; Tokuda Hajime
Depletion of SecDF-YajC causes a decrease in the level of SecG: implication for their functional interaction.
FEBS letters 2003;550(1-3):114-8.
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2003: Narita Shin-ichiro; Kanamaru Kyoko; Matsuyama Shin-ichi; Tokuda Hajime
A mutation in the membrane subunit of an ABC transporter LolCDE complex causing outer membrane localization of lipoproteins against their inner membrane-specific signals.
Molecular microbiology 2003;49(1):167-77.
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2003: Tokuda Hajime
[Protein localization in bacteria]
Seikagaku. The Journal of Japanese Biochemical Society 2003;75(2):109-18.
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2002: Fukuda Ayumu; Matsuyama Shin-Ichi; Hara Takashi; Nakayama Jiro; Nagasawa Hiromichi; Tokuda Hajime
Aminoacylation of the N-terminal cysteine is essential for Lol-dependent release of lipoproteins from membranes but does not depend on lipoprotein sorting signals.
The Journal of biological chemistry 2002;277(45):43512-8.
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2002: Nagamori Shushi; Nishiyama Ken-ichi; Tokuda Hajime
Membrane topology inversion of SecG detected by labeling with a membrane-impermeable sulfhydryl reagent that causes a close association of SecG with SecA.
Journal of biochemistry 2002;132(4):629-34.
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2002: Miyamoto Atsuki; Matsuyama Shin-ichi; Tokuda Hajime
Dominant negative mutant of a lipoprotein-specific molecular chaperone, LolA, tightly associates with LolCDE.
FEBS letters 2002;528(1-3):193-6.
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2002: Masuda Kazuhiro; Matsuyama Shin-ichi; Tokuda Hajime
Elucidation of the function of lipoprotein-sorting signals that determine membrane localization.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7390-5.
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2002: Narita Shin-ichiro; Tanaka Kimie; Matsuyama Shin-ichi; Tokuda Hajime
Disruption of lolCDE, encoding an ATP-binding cassette transporter, is lethal for Escherichia coli and prevents release of lipoproteins from the inner membrane.
Journal of bacteriology 2002;184(5):1417-22.
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2001: Terada M; Kuroda T; Matsuyama S I; Tokuda H
Lipoprotein sorting signals evaluated as the LolA-dependent release of lipoproteins from the cytoplasmic membrane of Escherichia coli.
The Journal of biological chemistry 2001;276(50):47690-4.
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2001: Tanaka K; Matsuyama S I; Tokuda H
Deletion of lolB, encoding an outer membrane lipoprotein, is lethal for Escherichia coli and causes accumulation of lipoprotein localization intermediates in the periplasm.
Journal of bacteriology 2001;183(22):6538-42.
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2001: Miyamoto A; Matsuyama Si; Tokuda H
Mutant of LolA, a lipoprotein-specific molecular chaperone of Escherichia coli, defective in the transfer of lipoproteins to LolB.
Biochemical and biophysical research communications 2001;287(5):1125-8.
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2001: Sugai R; Shimizu H; Nishiyama K; Tokuda H
Overexpression of yccL (gnsA) and ydfY (gnsB) increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation of Escherichia coli.
Journal of bacteriology 2001;183(19):5523-8.
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2000: Nishiyama K; Suzuki H; Tokuda H
Role of the non-essential region encompassing the N-terminal two transmembrane stretches of Escherichia coli SecE.
Bioscience, biotechnology, and biochemistry 2000;64(10):2121-7.
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2000: Yakushi T; Matsuyama S; Tokuda H
[Biogenesis of lipoproteins in gram-negative bacteria: mechanisms underlying the selective membrane localization of lipoproteins]
Nippon saikingaku zasshi. Japanese journal of bacteriology 2000;55(3):517-26.
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2000: Nagamori S; Nishiyama K; Tokuda H
Two SecG molecules present in a single protein translocation machinery are functional even after crosslinking.
Journal of biochemistry 2000;128(1):129-37.
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2000: Yakushi T; Masuda K; Narita S; Matsuyama S; Tokuda H
A new ABC transporter mediating the detachment of lipid-modified proteins from membranes.
Nature cell biology 2000;2(4):212-8.
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1999: Yokota N; Kuroda T; Matsuyama S; Tokuda H
Characterization of the LolA-LolB system as the general lipoprotein localization mechanism of Escherichia coli.
The Journal of biological chemistry 1999;274(43):30995-9.
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1998: Yakushi T; Yokota N; Matsuyama S; Tokuda H
LolA-dependent release of a lipid-modified protein from the inner membrane of Escherichia coli requires nucleoside triphosphate.
The Journal of biological chemistry 1998;273(49):32576-81.
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1998: Tajima T; Yokota N; Matsuyama S; Tokuda H
Genetic analyses of the in vivo function of LolA, a periplasmic chaperone involved in the outer membrane localization of Escherichia coli lipoproteins.
FEBS letters 1998;439(1-2):51-4.
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1998: Nishiyama K; Furuta M; Tokuda H
Molecular cloning and functional characterization of SecE of a marine bacterium, Vibrio alginolyticus.
Biochemical and biophysical research communications 1998;251(3):894-7.
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1998: Suzuki H; Nishiyama K; Tokuda H
Coupled structure changes of SecA and SecG revealed by the synthetic lethality of the secAcsR11 and delta secG::kan double mutant.
Molecular microbiology 1998;29(1):331-41.
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1997: Shimizu H; Nishiyama K; Tokuda H
Expression of gpsA encoding biosynthetic sn-glycerol 3-phosphate dehydrogenase suppresses both the LB- phenotype of a secB null mutant and the cold-sensitive phenotype of a secG null mutant.
Molecular microbiology 1997;26(5):1013-21.
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1997: Matsuyama S i; Yokota N; Tokuda H
A novel outer membrane lipoprotein, LolB (HemM), involved in the LolA (p20)-dependent localization of lipoproteins to the outer membrane of Escherichia coli.
The EMBO journal 1997;16(23):6947-55.
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1997: Yakushi T; Tajima T; Matsuyama S; Tokuda H
Lethality of the covalent linkage between mislocalized major outer membrane lipoprotein and the peptidoglycan of Escherichia coli.
Journal of bacteriology 1997;179(9):2857-62.
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1996: Hanada M; Nishiyama K; Tokuda H
SecG plays a critical role in protein translocation in the absence of the proton motive force as well as at low temperature.
FEBS letters 1996;381(1-2):25-8.
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1995: Matsuyama S; Tajima T; Tokuda H
A novel periplasmic carrier protein involved in the sorting and transport of Escherichia coli lipoproteins destined for the outer membrane.
The EMBO journal 1995;14(14):3365-72.
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1995: Kontinen V P; Tokuda H
Overexpression of phosphatidylglycerophosphate synthase restores protein translocation in a secG deletion mutant of Escherichia coli at low temperature.
FEBS letters 1995;364(2):157-60.
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1994: Hanada M; Nishiyama K I; Mizushima S; Tokuda H
Reconstitution of an efficient protein translocation machinery comprising SecA and the three membrane proteins, SecY, SecE, and SecG (p12).
The Journal of biological chemistry 1994;269(38):23625-31.
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1994: Nishiyama K; Hanada M; Tokuda H
Disruption of the gene encoding p12 (SecG) reveals the direct involvement and important function of SecG in the protein translocation of Escherichia coli at low temperature.
The EMBO journal 1994;13(14):3272-7.
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1994: Tokuda H
Biochemical characterization of the presecretory protein translocation machinery of Escherichia coli.
FEBS letters 1994;346(1):65-8.
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1993: Nishiyama K; Mizushima S; Tokuda H
A novel membrane protein involved in protein translocation across the cytoplasmic membrane of Escherichia coli.
The EMBO journal 1993;12(9):3409-15.
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