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Hajime Tokuda

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Escherichia coli

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Publications

TOP 3
Chihiro Sakamoto; Rika Satou; Hajime Tokuda; Shin-Ichiro Narita
Novel mutations of the LolCDE complex causing outer membrane localization of lipoproteins despite their inner membrane-retention signals.
Ken-ichi Nishiyama; Masahide Maeda; Masato Abe; Takashi Kanamori; Keiko Shimamoto; Shoichi Kusumoto; Takuya Ueda; Hajime Tokuda
A novel complete reconstitution system for membrane integration of the simplest membrane protein.
Shin-Ichiro Narita; Hajime Tokuda
Sorting of bacterial lipoproteins to the outer membrane by the Lol system.

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All Publications

2010: Chihiro Sakamoto; Rika Satou; Hajime Tokuda; Shin-Ichiro Narita
Novel mutations of the LolCDE complex causing outer membrane localization of lipoproteins despite their inner membrane-retention signals.
Biochemical and biophysical research communications 2010;401(4):586-91.
2010: Ken-ichi Nishiyama; Masahide Maeda; Masato Abe; Takashi Kanamori; Keiko Shimamoto; Shoichi Kusumoto; Takuya Ueda; Hajime Tokuda
A novel complete reconstitution system for membrane integration of the simplest membrane protein.
Biochemical and biophysical research communications 2010;394(3):733-6.
2010: Shin-Ichiro Narita; Hajime Tokuda
Sorting of bacterial lipoproteins to the outer membrane by the Lol system.
Methods in molecular biology (Clifton, N.J.) 2010;619():117-29.
2009: Ken-ichi Nishiyama; Hajime Tokuda
Development of a functional in vitro integration system for an integral membrane protein, SecG.
Biochemical and biophysical research communications 2009;390(3):920-4.
2009: Masaki Yasuda; Asako Iguchi-Yokoyama; Shin-Ichi Matsuyama; Hajime Tokuda; Shin-Ichiro Narita
Membrane topology and functional importance of the periplasmic region of ABC transporter LolCDE.
Bioscience, biotechnology, and biochemistry 2009;73(10):2310-6.
2009: Jun Tsukahara; Shin-Ichiro Narita; Hajime Tokuda
Real time analysis of lipoprotein transfer from LolA to LolB by means of surface plasmon resonance.
FEBS letters 2009;583(18):2987-90.
2009: Jun Tsukahara; Keita Mukaiyama; Suguru Okuda; Shin-ichiro Narita; Hajime Tokuda
Dissection of LolB function--lipoprotein binding, membrane targeting and incorporation of lipoproteins into lipid bilayers.
The FEBS journal 2009;276(16):4496-504.
2009: Shin-ichiro Narita; Hajime Tokuda
Biochemical characterization of an ABC transporter LptBFGC complex required for the outer membrane sorting of lipopolysaccharides.
FEBS letters 2009;583(13):2160-4.
2009: Suguru Okuda; Hajime Tokuda
Model of mouth-to-mouth transfer of bacterial lipoproteins through inner membrane LolC, periplasmic LolA, and outer membrane LolB.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(14):5877-82.
2009: Hajime Tokuda
Biogenesis of outer membranes in Gram-negative bacteria.
Bioscience, biotechnology, and biochemistry 2009;73(3):465-73.
2008: Shoji Watanabe; Yuki Oguchi; Kazuki Takeda; Kunio Miki; Hajime Tokuda
Introduction of a lethal redox switch that controls the opening and closing of the hydrophobic cavity in LolA.
The Journal of biological chemistry 2008;283(37):25421-7.
2008: Yuki Oguchi; Kazuki Takeda; Shoji Watanabe; N Yokota; Kunio Miki; Hajime Tokuda
Opening and closing of the hydrophobic cavity of LolA coupled to lipoprotein binding and release.
The Journal of biological chemistry 2008;283(37):25414-20.
2008: Yosuke Kawashima; Emi Miyazaki; Matthias Müller; Hajime Tokuda; Ken-ichi Nishiyama
Diacylglycerol specifically blocks spontaneous integration of membrane proteins and allows detection of a factor-assisted integration.
The Journal of biological chemistry 2008;283(36):24489-96.
2008: Suguru Okuda; Shoji Watanabe; Hajime Tokuda
A short helix in the C-terminal region of LolA is important for the specific membrane localization of lipoproteins.
FEBS letters 2008;582(15):2247-51.
2008: Naohiro Taniguchi; Hajime Tokuda
Molecular events involved in a single cycle of ligand transfer from an ATP binding cassette transporter, LolCDE, to a molecular chaperone, LolA.
The Journal of biological chemistry 2008;283(13):8538-44.
2007: Rie Sugai; Kazuhisa Takemae; Hajime Tokuda; Ken-ichi Nishiyama
Topology inversion of SecG is essential for cytosolic SecA-dependent stimulation of protein translocation.
The Journal of biological chemistry 2007;282(40):29540-8.
2007: Shigehiko Miyamoto; Hajime Tokuda
Diverse effects of phospholipids on lipoprotein sorting and ATP hydrolysis by the ABC transporter LolCDE complex.
Biochimica et biophysica acta 2007;1768(7):1848-54.
2007: Kengo Kanamaru; Naohiro Taniguchi; Shigehiko Miyamoto; Shin-ichiro Narita; Hajime Tokuda
Complete reconstitution of an ATP-binding cassette transporter LolCDE complex from separately isolated subunits.
The FEBS journal 2007;274(12):3034-43.
2007: Shin-Ichiro Narita; Hajime Tokuda
Amino acids at positions 3 and 4 determine the membrane specificity of Pseudomonas aeruginosa lipoproteins.
The Journal of biological chemistry 2007;282(18):13372-8.
2007: Shin-Ya Tanaka; Shin-Ichiro Narita; Hajime Tokuda
Characterization of the Pseudomonas aeruginosa Lol system as a lipoprotein sorting mechanism.
The Journal of biological chemistry 2007;282(18):13379-84.
2006: Yasuko Ito; Kengo Kanamaru; Naohiro Taniguchi; Shigehiko Miyamoto; Hajime Tokuda
A novel ligand bound ABC transporter, LolCDE, provides insights into the molecular mechanisms underlying membrane detachment of bacterial lipoproteins.
Molecular microbiology 2006;62(4):1064-75.
2006: Yasuko Ito; Hitomi Matsuzawa; Shin-ichi Matsuyama; Shin-ichiro Narita; Hajime Tokuda
Genetic analysis of the mode of interplay between an ATPase subunit and membrane subunits of the lipoprotein-releasing ATP-binding cassette transporter LolCDE.
Journal of bacteriology 2006;188(8):2856-64.
2006: Shin-ichiro Narita; Hajime Tokuda
An ABC transporter mediating the membrane detachment of bacterial lipoproteins depending on their sorting signals.
FEBS letters 2006;580(4):1164-70.
2006: Shoji Watanabe; Shin-ichi Matsuyama; Hajime Tokuda
Roles of the hydrophobic cavity and lid of LolA in the lipoprotein transfer reaction in Escherichia coli.
The Journal of biological chemistry 2006;281(6):3335-42.
2005: Naohiro Taniguchi; Shin-Ichi Matsuyama; Hajime Tokuda
Mechanisms underlying energy-independent transfer of lipoproteins from LolA to LolB, which have similar unclosed {beta}-barrel structures.
The Journal of biological chemistry 2005;280(41):34481-8.
2005: Ayao Ikegami; Ken-ichi Nishiyama; Shin-ichi Matsuyama; Hajime Tokuda
Disruption of rpmJ encoding ribosomal protein L36 decreases the expression of secY upstream of the spc operon and inhibits protein translocation in Escherichia coli.
Bioscience, biotechnology, and biochemistry 2005;69(8):1595-602.
2005: Ken-ichi Nishiyama; Hajime Tokuda
Genes coding for SecG and Leu2-tRNA form an operon to give an unusual RNA comprising mRNA and a tRNA precursor.
Biochimica et biophysica acta 2005;1729(3):166-73.
2004: Hajime Tokuda; Shin-ichi Matsuyama
Sorting of lipoproteins to the outer membrane in E. coli.
Biochimica et biophysica acta 2004;1694(1-3):IN1-9.
2004: Rieko Wada; Shin-ichi Matsuyama; Hajime Tokuda
Targeted mutagenesis of five conserved tryptophan residues of LolB involved in membrane localization of Escherichia coli lipoproteins.
Biochemical and biophysical research communications 2004;323(3):1069-74.
2004: Hidenori Miyadai; Kimie Tanaka-Masuda; Shin-ichi Matsuyama; Hajime Tokuda
Effects of lipoprotein overproduction on the induction of DegP (HtrA) involved in quality control in the Escherichia coli periplasm.
The Journal of biological chemistry 2004;279(38):39807-13.
2004: Rie Sugai; Hisayo Shimizu; Ken-Ichi Nishiyama; Hajime Tokuda
Overexpression of gnsA, a multicopy suppressor of the secG null mutation, increases acidic phospholipid contents by inhibiting phosphatidylethanolamine synthesis at low temperatures.
Journal of bacteriology 2004;186(17):5968-71.
2004: Shin-Ichiro Narita; Shin-Ichi Matsuyama; Hajime Tokuda
Lipoprotein trafficking in Escherichia coli.
Archives of microbiology 2004;182(1):1-6.
2004: Hajime Tokuda; Shin-Ichi Matsuyama
Sorting of lipoproteins to the outer membrane in E. coli.
Biochimica et biophysica acta 2004;1693(1):5-13.
2003: Takashi Hara; Shin-ichi Matsuyama; Hajime Tokuda
Mechanism underlying the inner membrane retention of Escherichia coli lipoproteins caused by Lol avoidance signals.
The Journal of biological chemistry 2003;278(41):40408-14.
2003: Yoshihisa Kato; Ken-ichi Nishiyama; Hajime Tokuda
Depletion of SecDF-YajC causes a decrease in the level of SecG: implication for their functional interaction.
FEBS letters 2003;550(1-3):114-8.
2003: Shin-ichiro Narita; Kengo Kanamaru; Shin-ichi Matsuyama; Hajime Tokuda
A mutation in the membrane subunit of an ABC transporter LolCDE complex causing outer membrane localization of lipoproteins against their inner membrane-specific signals.
Molecular microbiology 2003;49(1):167-77.
2003: Hajime Tokuda
[Protein localization in bacteria].
Seikagaku. The Journal of Japanese Biochemical Society 2003;75(2):109-18.
2002: Ayumu Fukuda; Shin-Ichi Matsuyama; Takashi Hara; Jiro Nakayama; Hiromichi Nagasawa; Hajime Tokuda
Aminoacylation of the N-terminal cysteine is essential for Lol-dependent release of lipoproteins from membranes but does not depend on lipoprotein sorting signals.
The Journal of biological chemistry 2002;277(45):43512-8.
2002: Shushi Nagamori; Ken-ichi Nishiyama; Hajime Tokuda
Membrane topology inversion of SecG detected by labeling with a membrane-impermeable sulfhydryl reagent that causes a close association of SecG with SecA.
Journal of biochemistry 2002;132(4):629-34.
2002: Atsuki Miyamoto; Shin-ichi Matsuyama; Hajime Tokuda
Dominant negative mutant of a lipoprotein-specific molecular chaperone, LolA, tightly associates with LolCDE.
FEBS letters 2002;528(1-3):193-6.
2002: Kazuhiro Masuda; Shin-ichi Matsuyama; Hajime Tokuda
Elucidation of the function of lipoprotein-sorting signals that determine membrane localization.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7390-5.
2002: Shin-ichiro Narita; Kimie Tanaka; Shin-ichi Matsuyama; Hajime Tokuda
Disruption of lolCDE, encoding an ATP-binding cassette transporter, is lethal for Escherichia coli and prevents release of lipoproteins from the inner membrane.
Journal of bacteriology 2002;184(5):1417-22.
2001: M Terada; T Kuroda; Shin-ichi Matsuyama; Hajime Tokuda
Lipoprotein sorting signals evaluated as the LolA-dependent release of lipoproteins from the cytoplasmic membrane of Escherichia coli.
The Journal of biological chemistry 2001;276(50):47690-4.
2001: Keiichi Tanaka; Shin-ichi Matsuyama; Hajime Tokuda
Deletion of lolB, encoding an outer membrane lipoprotein, is lethal for Escherichia coli and causes accumulation of lipoprotein localization intermediates in the periplasm.
Journal of bacteriology 2001;183(22):6538-42.
2001: A Miyamoto; Hajime Tokuda
Mutant of LolA, a lipoprotein-specific molecular chaperone of Escherichia coli, defective in the transfer of lipoproteins to LolB.
Biochemical and biophysical research communications 2001;287(5):1125-8.
2001: Rie Sugai; H Shimizu; Ken-ichi Nishiyama; Hajime Tokuda
Overexpression of yccL (gnsA) and ydfY (gnsB) increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation of Escherichia coli.
Journal of bacteriology 2001;183(19):5523-8.
2000: Ken-ichi Nishiyama; H Suzuki; Hajime Tokuda
Role of the non-essential region encompassing the N-terminal two transmembrane stretches of Escherichia coli SecE.
Bioscience, biotechnology, and biochemistry 2000;64(10):2121-7.
2000: T Yakushi; Shin-ichi Matsuyama; Hajime Tokuda
[Biogenesis of lipoproteins in gram-negative bacteria: mechanisms underlying the selective membrane localization of lipoproteins].
Nihon saikingaku zasshi. Japanese journal of bacteriology 2000;55(3):517-26.
2000: Shushi Nagamori; Ken-ichi Nishiyama; Hajime Tokuda
Two SecG molecules present in a single protein translocation machinery are functional even after crosslinking.
Journal of biochemistry 2000;128(1):129-37.
2000: T Yakushi; K Masuda; S Narita; Shin-ichi Matsuyama; Hajime Tokuda
A new ABC transporter mediating the detachment of lipid-modified proteins from membranes.
Nature cell biology 2000;2(4):212-8.
1999: N Yokota; T Kuroda; Shin-ichi Matsuyama; Hajime Tokuda
Characterization of the LolA-LolB system as the general lipoprotein localization mechanism of Escherichia coli.
The Journal of biological chemistry 1999;274(43):30995-9.
1998: T Yakushi; N Yokota; Shin-ichi Matsuyama; Hajime Tokuda
LolA-dependent release of a lipid-modified protein from the inner membrane of Escherichia coli requires nucleoside triphosphate.
The Journal of biological chemistry 1998;273(49):32576-81.
1998: T Tajima; N Yokota; Shin-ichi Matsuyama; Hajime Tokuda
Genetic analyses of the in vivo function of LolA, a periplasmic chaperone involved in the outer membrane localization of Escherichia coli lipoproteins.
FEBS letters 1998;439(1-2):51-4.
1998: K Nishiyama; M Furuta; Hajime Tokuda
Molecular cloning and functional characterization of SecE of a marine bacterium, Vibrio alginolyticus.
Biochemical and biophysical research communications 1998;251(3):894-7.
1998: H Suzuki; K Nishiyama; Hajime Tokuda
Coupled structure changes of SecA and SecG revealed by the synthetic lethality of the secAcsR11 and delta secG::kan double mutant.
Molecular microbiology 1998;29(1):331-41.
1997: H Shimizu; K Nishiyama; Hajime Tokuda
Expression of gpsA encoding biosynthetic sn-glycerol 3-phosphate dehydrogenase suppresses both the LB- phenotype of a secB null mutant and the cold-sensitive phenotype of a secG null mutant.
Molecular microbiology 1997;26(5):1013-21.
1997: Shin-ichi Matsuyama; N Yokota; Hajime Tokuda
A novel outer membrane lipoprotein, LolB (HemM), involved in the LolA (p20)-dependent localization of lipoproteins to the outer membrane of Escherichia coli.
The EMBO journal 1997;16(23):6947-55.
1997: T Yakushi; T Tajima; Shin-ichi Matsuyama; Hajime Tokuda
Lethality of the covalent linkage between mislocalized major outer membrane lipoprotein and the peptidoglycan of Escherichia coli.
Journal of bacteriology 1997;179(9):2857-62.
1996: M Hanada; K Nishiyama; Hajime Tokuda
SecG plays a critical role in protein translocation in the absence of the proton motive force as well as at low temperature.
FEBS letters 1996;381(1-2):25-8.
1995: Shin-ichi Matsuyama; T Tajima; Hajime Tokuda
A novel periplasmic carrier protein involved in the sorting and transport of Escherichia coli lipoproteins destined for the outer membrane.
The EMBO journal 1995;14(14):3365-72.
1995: V P Kontinen; Hajime Tokuda
Overexpression of phosphatidylglycerophosphate synthase restores protein translocation in a secG deletion mutant of Escherichia coli at low temperature.
FEBS letters 1995;364(2):157-60.
1994: M Hanada; K I Nishiyama; S Mizushima; Hajime Tokuda
Reconstitution of an efficient protein translocation machinery comprising SecA and the three membrane proteins, SecY, SecE, and SecG (p12).
The Journal of biological chemistry 1994;269(38):23625-31.
1994: K Nishiyama; M Hanada; Hajime Tokuda
Disruption of the gene encoding p12 (SecG) reveals the direct involvement and important function of SecG in the protein translocation of Escherichia coli at low temperature.
The EMBO journal 1994;13(14):3272-7.
1994: Hajime Tokuda
Biochemical characterization of the presecretory protein translocation machinery of Escherichia coli.
FEBS letters 1994;346(1):65-8.
1993: K Nishiyama; S Mizushima; Hajime Tokuda
A novel membrane protein involved in protein translocation across the cytoplasmic membrane of Escherichia coli.
The EMBO journal 1993;12(9):3409-15.