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Yutaka Tokumaru

Research Profile

Disorders

Physiology

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Genes & Molecular Sequences

Genes, Tumor Suppressor

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Publications

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Yutaka Tokumaru; Keishi Yamashita; Myoung Sook Kim; Hannah Lui Park; Motonobu Osada; Masaki Mori; David Sidransky
The role of PGP9.5 as a tumor suppressor gene in human cancer.
Keishi Yamashita; Myoung Sook Kim; Hannah Lui Park; Yutaka Tokumaru; Motonobu Osada; Hiroshi Inoue; Masaki Mori; David Sidransky
HOP/OB1/NECC1 promoter DNA is frequently hypermethylated and involved in tumorigenic ability in esophageal squamous cell carcinoma.
André Lopes Carvalho; Carmen Jeronimo; Michael M Kim; Rui Henrique; Zhe Zhang; Mohammad Hoque; Steve Chang; Mariana Brait; Chetan Nayak; Wei-Wen Jiang; Quia Claybourne; Yutaka Tokumaru; Juna Lee; David Goldenberg; Elizabeth Garrett-Mayer; Steven Goodman; Chulso Moon; Wayne M Koch; William H Westra; David Sidransky; Joseph A Califano
Evaluation of promoter hypermethylation detection in body fluids as a screening/diagnosis tool for head and neck squamous cell carcinoma.

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All Publications

2008: Yutaka Tokumaru; Keishi Yamashita; Myoung Sook Kim; Hannah Lui Park; Motonobu Osada; Masaki Mori; David Sidransky
The role of PGP9.5 as a tumor suppressor gene in human cancer.
International journal of cancer. Journal international du cancer 2008;123(4):753-9.
2008: Keishi Yamashita; Myoung Sook Kim; Hannah Lui Park; Yutaka Tokumaru; Motonobu Osada; Hiroshi Inoue; Masaki Mori; David Sidransky
HOP/OB1/NECC1 promoter DNA is frequently hypermethylated and involved in tumorigenic ability in esophageal squamous cell carcinoma.
Molecular cancer research : MCR 2008;6(1):31-41.
2008: André Lopes Carvalho; Carmen Jeronimo; Michael M Kim; Rui Henrique; Zhe Zhang; Mohammad Hoque; Steve Chang; Mariana Brait; Chetan Nayak; Wei-Wen Jiang; Quia Claybourne; Yutaka Tokumaru; Juna Lee; David Goldenberg; Elizabeth Garrett-Mayer; Steven Goodman; Chulso Moon; Wayne M Koch; William H Westra; David Sidransky; Joseph A Califano
Evaluation of promoter hypermethylation detection in body fluids as a screening/diagnosis tool for head and neck squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(1):97-107.
2007: Myoung Sook Kim; Keishi Yamashita; Young Kwang Chae; Yutaka Tokumaru; Xiaofei Chang; Marianna Zahurak; Motonobu Osada; Hannah Lui Park; Alice Chuang; Joseph A Califano; David Sidransky
A promoter methylation pattern in the N-methyl-D-aspartate receptor 2B gene predicts poor prognosis in esophageal squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(22 Pt 1):6658-65.
2007: Tomohisa Nagasao; Junpei Miyamoto; Makoto Hikosaka; Maki Nagasao; Yutaka Tokumaru; Kaoru Ogawa; Tatsuo Nakajima
Appropriate diameter for screws to fix the maxilla following Le Fort I osteotomy: an investigation utilizing finite element analysis.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 2007;35(4-5):227-33.
2006: Keishi Yamashita; Hannah Lui Park; Myoung Sook Kim; Motonobu Osada; Yutaka Tokumaru; Hiroshi Inoue; Masaki Mori; David Sidransky
PGP9.5 methylation in diffuse-type gastric cancer.
Cancer research 2006;66(7):3921-7.
2005: Diana L Mandelker; Keishi Yamashita; Yutaka Tokumaru; Koshi Mimori; David L Howard; Yoichi Tanaka; André Lopes Carvalho; Wei-Wen Jiang; Hannah Lui Park; Myoung Sook Kim; Motonobu Osada; Masaki Mori; David Sidransky
PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma.
Cancer research 2005;65(11):4963-8.
2004: Yutaka Tokumaru; Keishi Yamashita; Motonobu Osada; Shuji Nomoto; Dong-Il Sun; Yan Xiao; Mohammad Hoque; William H Westra; Joseph A Califano; David Sidransky
Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing.
Cancer research 2004;64(17):5982-7.
2004: Yutaka Tokumaru; Susan V Harden; Dong-Il Sun; Keishi Yamashita; Jonathan I Epstein; David Sidransky
Optimal use of a panel of methylation markers with GSTP1 hypermethylation in the diagnosis of prostate adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(16):5518-22.
2004: Ming Zhou; Yutaka Tokumaru; David Sidransky; Jonathan I Epstein
Quantitative GSTP1 methylation levels correlate with Gleason grade and tumor volume in prostate needle biopsies.
The Journal of urology 2004;171(6 Pt 1):2195-8.
2004: Ozlem Topaloglu; Mohammad Hoque; Yutaka Tokumaru; Juna Lee; Edward Ratovitski; David Sidransky; Chulso Moon
Detection of promoter hypermethylation of multiple genes in the tumor and bronchoalveolar lavage of patients with lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(7):2284-8.
2003: Yutaka Tokumaru; Shuji Nomoto; Carmen Jerónimo; Rui Henrique; Susan V Harden; Barry Trink; David Sidransky
Biallelic inactivation of the RIZ1 gene in human gastric cancer.
Oncogene 2003;22(44):6954-8.
2003: Yutaka Tokumaru; Dong-Il Sun; Shuji Nomoto; Keishi Yamashita; David Sidransky
Re: Is TIG1 a new tumor suppressor in prostate cancer?
Journal of the National Cancer Institute 2003;95(12):919-20.
2003: Taku Yamashita; Masato Fujii; Toshiki Tomita; Ryuichirou Ishiguro; Masatsugu Tashiro; Yutaka Tokumaru; Yorihisa Imanishi; Minoru Kanke; Kaoru Ogawa; Kaori Kameyama; Yoshihide Otani
The inhibitory effect of matrix metalloproteinase inhibitor ONO-4817 on lymph node metastasis in tongue carcinoma.
Anticancer research 2003;23(3B):2297-302.
2003: Michael M. Xing; Henning Usadel; Yoram Cohen; Yutaka Tokumaru; Zhongmin Guo; William H Westra; Betty C Tong; Giovanni Tallini; Robert Udelsman; Joseph A Califano; Paul W Ladenson; David Sidransky
Methylation of the thyroid-stimulating hormone receptor gene in epithelial thyroid tumors: a marker of malignancy and a cause of gene silencing.
Cancer research 2003;63(9):2316-21.
2003: Michael M. Xing; Yutaka Tokumaru; Guojun Wu ; William H Westra; Paul W Ladenson; David Sidransky
Hypermethylation of the Pendred syndrome gene SLC26A4 is an early event in thyroid tumorigenesis.
Cancer research 2003;63(9):2312-5.
2003: Susan V Harden; Yutaka Tokumaru; William H Westra; Steven Goodman; Steven A Ahrendt; Stephen C Yang; David Sidransky
Gene promoter hypermethylation in tumors and lymph nodes of stage I lung cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(4):1370-5.
2002: Taku Yamashita; Masato Fujii; Ryuichirou Ishiguro; Masatsugu Tashiro; Yoshihiro Ohno; Yutaka Tokumaru; Minoru Kanke; Yorihisa Imanishi; Toshiki Tomita; Jin Kanzaki; Yukio Inuyama
[Statistical analysis of maxillary sinus squamous cell carcinoma].
Nihon Jibiinkoka Gakkai kaiho 2002;105(6):732-40.
2001: Masato Fujii; Y Ohno; Yutaka Tokumaru; Yorihisa Imanishi; Minoru Kanke; T Tomita; Jin Kanzaki
Manifest Anxiety Scale for evaluation of effects of granisetron in chemotherapy with CDDP and 5FU for head and neck cancer.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2001;9(5):366-71.
2000: Masato Fujii; Y Ohno; Yutaka Tokumaru; Yorihisa Imanishi; Minoru Kanke; Toshiki Tomita; Taku Yamashita
UFT plus carboplatin for head and neck cancer.
Oncology (Williston Park, N.Y.) 2000;14(10 Suppl 9):72-5.
2000: Minoru Kanke; Masato Fujii; Kaori Kameyama; Jin Kanzaki; Yutaka Tokumaru; Yorihisa Imanishi; T Tomita; Y Matsumura
Role of CD44 variant exon 6 in invasion of head and neck squamous cell carcinoma.
Archives of otolaryngology--head & neck surgery 2000;126(10):1217-23.
2000: Yorihisa Imanishi; Masato Fujii; Yutaka Tokumaru; Toshiki Tomita; Minoru Kanke; Jin Kanzaki; Kaori Kameyama; Yoshihide Otani; Hiroshi Sato
Clinical significance of expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 in human head and neck squamous cell carcinoma.
Human pathology 2000;31(8):895-904.
2000: Toshiki Tomita; Masato Fujii; Yutaka Tokumaru; Yorihisa Imanishi; Minoru Kanke; Taku Yamashita; Ryuichirou Ishiguro; Jin Kanzaki; Kaori Kameyama; Yoshihide Otani
Granulocyte-macrophage colony-stimulating factor upregulates matrix metalloproteinase-2 (MMP-2) and membrane type-1 MMP (MT1-MMP) in human head and neck cancer cells.
Cancer letters 2000;156(1):83-91.
2000: Minoru Kanke; Masato Fujii; Kaori Kameyama; Jin Kanzaki; Yutaka Tokumaru; Yorihisa Imanishi; T Tomita; Y Matsumura
Clinicopathological significance of expression of CD44 variants in head and neck squamous cell carcinoma.
Japanese journal of cancer research : Gann 2000;91(4):410-5.
2000: Yutaka Tokumaru; Masato Fujii; Yoshihide Otani; Kaori Kameyama; Yorihisa Imanishi; N Igarashi; Jin Kanzaki
Activation of matrix metalloproteinase-2 in head and neck squamous cell carcinoma: studies of clinical samples and in vitro cell lines co-cultured with fibroblasts.
Cancer letters 2000;150(1):15-21.
1999: Toshiki Tomita; Masato Fujii; Yorihisa Imanishi; Minoru Kanke; Jin Kanzaki; Yoshihiro Ohno; Yutaka Tokumaru; Yukio Inuyama
[Statistical analysis of localized non-Hodgkin's lymphomas of the head and neck--multivariate analysis of prognostic factors and evaluation of therapeutic modalities].
Nihon Jibiinkoka Gakkai kaiho 1999;102(6):809-17.
1998: Yorihisa Imanishi; Masato Fujii; Yutaka Tokumaru; Minoru Kanke; Toshiki Tomita; Jin Kanzaki; Yoshihiro Ohno; Yukio Inuyama
[Statistical analysis of oropharyngeal squamous cell carcinoma--multivariate analysis of prognostic factors and evaluation of therapeutic modalities].
Nihon Jibiinkoka Gakkai kaiho 1998;101(5):602-14.
1998: Minoru Kanke; F Masato; Yoshihiro Ohno; Yutaka Tokumaru; Yorihisa Imanishi; Toshiki Tomita; Y Inuyma; Jin Kanzaki
[Result of treatment of squamous cell carcinoma of the tongue and floor of the mouth].
Nihon Jibiinkoka Gakkai kaiho 1998;101(5):586-94.
1998: Masato Fujii; Yoshihiro Ohno; Yutaka Tokumaru; Yorihisa Imanishi; Minoru Kanke; Jin Kanzaki; Yukio Inuyama
Adjuvant chemotherapy with oral tegaful and uracil for maxillary sinus carcinoma.
Oncology 1998;55(2):109-15.
1998: Masato Fujii; Yutaka Tokumaru; Yorihisa Imanishi; Minoru Kanke; Jin Kanzaki; Y Ohno
[Combination chemotherapy with nedaplatin and 5-FU for head and neck cancer].
Gan to kagaku ryoho. Cancer & chemotherapy 1998;25(1):53-8.
1997: Masato Fujii; Y Ohno; Yutaka Tokumaru; Yorihisa Imanishi; Minoru Kanke; Jin Kanzaki
[Comparison of effects between single vs five-day injection of granisetron for combination chemotherapy with cisplatin and 5-fluorouracil for head and neck cancer].
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(9):1095-101.
1996: Masato Fujii; Yoshihiro Ohno; Yutaka Tokumaru; Yorihisa Imanishi; Minoru Kanke
[Combination chemotherapy with 5-FU and CDDP or CDDP analog for head and neck cancer].
Gan to kagaku ryoho. Cancer & chemotherapy 1996;23(13):1740-6.