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Lisardo Boscá

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Paqui G Través; Luz María G Carrasquero; Esmerilda G Delicado; Manuel Izquierdo; Alfonso Luque; Paloma Martín-Sanz; María Teresa Miras-Portugal; Raquel Pérez-Sen; María Pimentel-Santillana; Lisardo Boscá
Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses.
Jesús Cosin-Roger; Carme Cucarella; Ana Julia Fernández-Alvarez; Paloma Martin-Sanz; Santiago Vernia; Maria Soledad Alvarez; Lisardo Boscá; Marta Casado
Identification of a novel Pfkfb1 mRNA variant in rat fetal liver.
Paqui G Través; R López-Fontal; A Luque; Lisardo Boscá; I Cuadrado; B de las Heras; Sonsoles Hortelano
Critical role of the death receptor pathway in the antitumoral effects induced by hispanolone derivatives.

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2013: Paqui G Través; Luz María G Carrasquero; Esmerilda G Delicado; Manuel Izquierdo; Alfonso Luque; Paloma Martín-Sanz; María Teresa Miras-Portugal; Raquel Pérez-Sen; María Pimentel-Santillana; Lisardo Boscá
Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(8):4226-35.
2013: Jesús Cosin-Roger; Carme Cucarella; Ana Julia Fernández-Alvarez; Paloma Martin-Sanz; Santiago Vernia; Maria Soledad Alvarez; Lisardo Boscá; Marta Casado
Identification of a novel Pfkfb1 mRNA variant in rat fetal liver.
Biochemical and biophysical research communications 2013;431(1):36-40.
2013: Paqui G Través; R López-Fontal; A Luque; Lisardo Boscá; I Cuadrado; B de las Heras; Sonsoles Hortelano
Critical role of the death receptor pathway in the antitumoral effects induced by hispanolone derivatives.
Oncogene 2013;32(2):259-68.
2012: Gema Ruiz-Hurtado; Tarik Smani; Lisardo Boscá; Victoria Cachofeiro; Eva Calderón; Javier Díez; María Fernández-Velasco; Ana María Gómez; Nieves Gómez-Hurtado; Antonio Ordoñez; Carmen Delgado
Cardiotrophin-1 induces sarcoplasmic reticulum Ca(2+) leak and arrhythmogenesis in adult rat ventricular myocytes.
Cardiovascular research 2012;96(1):81-9.
2012: Carlota García-Hoz; Michael Leitges; Federico Mayor; Jorge Moscat; Julia Palacios-García; Lisardo Boscá; Maria Teresa Díaz-Meco; María Fernández-Velasco; David García-Dorado; Ramón García-Escudero; Marisol Ruiz-Meana; Guzmán Sánchez-Fernández; Catalina Ribas
Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts.
The Journal of biological chemistry 2012;287(10):7792-802.
2012: Paqui G Través; Lisardo Boscá; Pedro de Atauri; Igor Marín de Mas; Silvia Marín; Paloma Martín-Sanz; María Pimentel-Santillana; Juan-Carlos Rodríguez-Prados; Vitaly A Selivanov; Marta Cascante
Relevance of the MEK/ERK signaling pathway in the metabolism of activated macrophages: a metabolomic approach.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(3):1402-10.
2012: A Fernández-Alvarez; C Llorente-Izquierdo; N Agra; Lisardo Boscá; Marta Casado; Rafael Mayoral; Paloma Martín-Sanz
Evaluation of epigenetic modulation of cyclooxygenase-2 as a prognostic marker for hepatocellular carcinoma.
Oncogenesis 2012;1():e23.
2012: Noelia Agra Andrieu; Lisardo Boscá; Marta Casado; Ana Fernández-Alvarez; Cristina Llorente Izquierdo; Rafael Mayoral; Omar Motiño; Paloma Martín-Sanz
Cyclooxygenase-2 is a target of microRNA-16 in human hepatoma cells.
PloS one 2012;7(11):e50935.
2012: María Fernández-Velasco; Juana M Flores; Mónica Gómez-Parrizas; Begoña Lavin; Eduardo López-Collazo; Paloma Martín-Sanz; Patricia Prieto; Verónica Terrón; Carlos Zaragoza; Gemma Benito; Carmen Delgado; Lisardo Boscá
NOD1 activation induces cardiac dysfunction and modulates cardiac fibrosis and cardiomyocyte apoptosis.
PloS one 2012;7(9):e45260.
2011: Marta López-Peláez; Irene Soria-Castro; Lisardo Boscá; Margarita Fernández; Susana Alemany
Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression.
European journal of immunology 2011;41(6):1733-41.
2011: Cristina Llorente Izquierdo; Rafael Mayoral; Juana María Flores; Pilar García-Palencia; Carme Cucarella; Lisardo Boscá; Marta Casado; Paloma Martín-Sanz
Transgenic mice expressing cyclooxygenase-2 in hepatocytes reveal a minor contribution of this enzyme to chemical hepatocarcinogenesis.
The American journal of pathology 2011;178(3):1361-73.
2011: I Cuadrado; Lisardo Boscá; María Fernández-Velasco; B de Las Heras
Labdane diterpenes protect against anoxia/reperfusion injury in cardiomyocytes: involvement of AKT activation.
Cell death & disease 2011;2():e229.
2011: Luciane A Faine; Suely L Galdino; B L Heras; Marcelo Zaldini Hernandes; M C A Lima; Ivan R Pitta; Martina Rudnicki; E S Souza; Lisardo Boscá; F A César; Dulcineia S P Abdalla
Anti-inflammatory and antioxidant properties of a new arylidene-thiazolidinedione in macrophages.
Current medicinal chemistry 2011;18(22):3351-60.
2011: Carmelo García-Monzón; Oreste Lo Iacono; Rafael Mayoral; Agueda González-Rodríguez; María E Miquilena-Colina; Tamara Lozano-Rodríguez; Leonor García-Pozo; Javier Vargas-Castrillón; Marta Casado; Lisardo Boscá; Angela M Valverde; Paloma Martín-Sanz
Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C.
Journal of hepatology 2011;54(1):142-52.
2010: Romina Manarin; Fernanda Pascutti; Juan Pablo Ruffino; Beatriz De Las Heras; Lisardo Boscá; Oscar Bottasso; Silvia Revelli; Esteban Serra
Benznidazole blocks NF-kappaB activation but not AP-1 through inhibition of IKK.
Molecular immunology 2010;47(15):2485-91.
2010: Juan-Carlos Rodríguez-Prados; Paqui G Través; Jimena Cuenca; Daniel Rico; Julián Aragonés; Paloma Martín-Sanz; Marta Cascante; Lisardo Boscá
Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(1):605-14.
2010: P Prieto; J Cuenca; P G Través; M Fernández-Velasco; P Martín-Sanz; Lisardo Boscá
Lipoxin A4 impairment of apoptotic signaling in macrophages: implication of the PI3K/Akt and the ERK/Nrf-2 defense pathways.
Cell death and differentiation 2010;17(7):1179-88.
2010: Vanessa Núñez; Daniel Alameda; Daniel Rico; Rubén Mota; Pilar Gonzalo; Marta Cedenilla; Thierry Fischer; Lisardo Boscá; Christopher K Glass; Alicia G Arroyo; Mercedes Ricote
Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(23):10626-31.
2010: Sonsoles Hortelano; Raquel López-Fontal; Paqui G Través; Natividad Villa; Carsten Grashoff; Lisardo Boscá; Alfonso Luque
ILK mediates LPS-induced vascular adhesion receptor expression and subsequent leucocyte trans-endothelial migration.
Cardiovascular research 2010;86(2):283-92.
2010: A M C Pedrosa; Luciane A Faine; D M Grosso; B de Las Heras; Lisardo Boscá; Dulcineia S P Abdalla
Electronegative LDL induction of apoptosis in macrophages: involvement of Nrf2.
Biochimica et biophysica acta 2010;1801(4):430-7.
2010: Paloma Martín-Sanz; Rafael Mayoral; Marta Casado; Lisardo Boscá
COX-2 in liver, from regeneration to hepatocarcinogenesis: what we have learned from animal models?
World journal of gastroenterology : WJG 2010;16(12):1430-5.
2010: Rafael Mayoral; Angela M Valverde; Cristina Llorente Izquierdo; Agueda González-Rodríguez; Lisardo Boscá; Paloma Martín-Sanz
Impairment of transforming growth factor beta signaling in caveolin-1-deficient hepatocytes: role in liver regeneration.
The Journal of biological chemistry 2010;285(6):3633-42.
2010: Luciane A Faine; Danielle M H Cavalcanti; Martina Rudnicki; Simone Ferderbar; Sandra M D Macedo; Heraldo P Souza; Sandra H P Farsky; Lisardo Boscá; Dulcineia Saes Parra Abdalla
Bioactivity of nitrolinoleate: effects on adhesion molecules and CD40-CD40L system.
The Journal of nutritional biochemistry 2010;21(2):125-32.
2010: Raquel López-Fontal; Miriam Zeini; Paqui G Través; Mariana Gómez-Ferrería; Ana Aranda; Guillermo T Sáez; Concha Cerdá; Paloma Martín-Sanz; Sonsoles Hortelano; Lisardo Boscá
Mice lacking thyroid hormone receptor Beta show enhanced apoptosis and delayed liver commitment for proliferation after partial hepatectomy.
PloS one 2010;5(1):e8710.
2009: Javier Inserte; Belén Molla; Rio Aguilar; Paqui G Través; Ignasi Barba; Paloma Martín-Sanz; Lisardo Boscá; Marta Casado; David Garcia-Dorado
Constitutive COX-2 activity in cardiomyocytes confers permanent cardioprotection Constitutive COX-2 expression and cardioprotection.
Journal of molecular and cellular cardiology 2009;46(2):160-8.
2008: Rafael Mayoral; Belen Mollá; Juana Maria Flores; Lisardo Boscá; Marta Casado; Paloma Martín-Sanz
Constitutive expression of cyclo-oxygenase 2 transgene in hepatocytes protects against liver injury.
The Biochemical journal 2008;416(3):337-46.
2008: Natalia Girón; Paqui G Través; B Rodríguez; Raquel López-Fontal; Lisardo Boscá; Sonsoles Hortelano; B de las Heras
Suppression of inflammatory responses by labdane-type diterpenoids.
Toxicology and applied pharmacology 2008;228(2):179-89.
2007: Jimena Cuenca; Nora Goren; Patricia Prieto; Paloma Martín-Sanz; Lisardo Boscá
Selective impairment of nuclear factor-kappaB-dependent gene transcription in adult cardiomyocytes: relevance for the regulation of the inflammatory response in the heart.
The American journal of pathology 2007;171(3):820-8.
2007: Rafael Mayoral; Amalia Fernández-Martínez; Rosa Roy; Lisardo Boscá; Paloma Martín-Sanz
Dispensability and dynamics of caveolin-1 during liver regeneration and in isolated hepatic cells.
Hepatology (Baltimore, Md.) 2007;46(3):813-22.
2007: B de las Heras; Sonsoles Hortelano; N Girón; Paulina Bermejo; B Rodríguez; Lisardo Boscá
Kaurane diterpenes protect against apoptosis and inhibition of phagocytosis in activated macrophages.
British journal of pharmacology 2007;152(2):249-55.
2007: Teresa Pérez de Prada; Aranzazu Ortega Pozzi; Mónica Torres Coronado; Marie Anne Pounchard; Pablo Gonzalez; Lisardo Boscá; Panayotis Fantidis
Atherogenesis takes place in cholesterol-fed rabbits when circulating concentrations of endogenous cortisol are increased and inflammation suppressed.
Atherosclerosis 2007;191(2):333-9.
2007: Eleuterio Lombardo; Alberto Alvarez-Barrientos; Beatriz Maroto; Lisardo Boscá; Ulla G Knaus
TLR4-mediated survival of macrophages is MyD88 dependent and requires TNF-alpha autocrine signalling.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3731-9.
2007: Marta Casado; Belén Mollá; Rosa Roy; Amalia Fernández-Martínez; Carme Cucarella; Rafael Mayoral; Lisardo Boscá; Paloma Martín-Sanz
Protection against Fas-induced liver apoptosis in transgenic mice expressing cyclooxygenase 2 in hepatocytes.
Hepatology (Baltimore, Md.) 2007;45(3):631-8.
2007: Daniel Rico; Juan M Vaquerizas; Hernan Dopazo; Lisardo Boscá
Identification of conserved domains in the promoter regions of nitric oxide synthase 2: implications for the species-specific transcription and evolutionary differences.
BMC genomics 2007;8():271.
2007: Sonsoles Hortelano; Miriam Zeini; Marta Casado; Paloma Martín-Sanz; Lisardo Boscá
Animal models for the study of liver regeneration: role of nitric oxide and prostaglandins.
Frontiers in bioscience : a journal and virtual library 2007;12():13-21.
2006: Jimena Cuenca; Paloma Martín-Sanz; Alberto M Alvarez-Barrientos; Lisardo Boscá; Nora Goren
Infiltration of inflammatory cells plays an important role in matrix metalloproteinase expression and activation in the heart during sepsis.
The American journal of pathology 2006;169(5):1567-76.
2006: Amalia Fernández-Martínez; Belén Mollá; Rafael Mayoral; Lisardo Boscá; Marta Casado; Paloma Martín-Sanz
Cyclo-oxygenase 2 expression impairs serum-withdrawal-induced apoptosis in liver cells.
The Biochemical journal 2006;398(3):371-80.
2006: Miriam Zeini; Paqui G Través; Raquel López-Fontal; Cristina Pantoja; Ander Matheu; Manuel Serrano; Lisardo Boscá; Sonsoles Hortelano
Specific contribution of p19(ARF) to nitric oxide-dependent apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):3327-36.
2006: Olga Millán; Daniel Rico; Héctor Peinado; Natasha Zarich; Konstantinos Stamatakis; Dolores Pérez-Sala; José M Rojas; Amparo Cano; Lisardo Boscá
Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis.
Carcinogenesis 2006;27(2):328-36.
2006: Marta Pereira; Olivia Hurtado; Antonio Cárdenas; Lisardo Boscá; José Castillo; Antoni Dávalos; José Vivancos; Joaquín Serena; Pedro Lorenzo; ignacio lizasoain; Maria Moro
Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006;26(2):218-29.
2006: Mercedes Fernandez-Pascual; M Mercedes Lucas; María R de Felipe; Lisardo Boscá; Heribert Hirt; Maria Pilar Golvano
Involvement of mitogen-activated protein kinases in the symbiosis Bradyrhizobium-Lupinus.
Journal of experimental botany 2006;57(11):2735-42.
2005: Marta Pereira; Olivia Hurtado; Antonio Cárdenas; David Alonso-Escolano; Lisardo Boscá; José Vivancos; Florentino Nombela; Juan C Leza; Pedro Lorenzo; ignacio lizasoain; Maria Moro
The nonthiazolidinedione PPARgamma agonist L-796,449 is neuroprotective in experimental stroke.
Journal of neuropathology and experimental neurology 2005;64(9):797-805.
2005: Lisardo Boscá; Santiago Lamas; Juan Miguel Redondo
Madrid center not quite in limbo.
Science (New York, N.Y.) 2005;309(5737):1017.
2005: Miriam Zeini; Sonsoles Hortelano; Paqui G Través; Alicia G Gómez-Valadés; Anna Pujol; jose perales; Ramon Bartrons; Lisardo Boscá
Assessment of a dual regulatory role for NO in liver regeneration after partial hepatectomy: protection against apoptosis and retardation of hepatocyte proliferation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(8):995-7.
2005: Rafael Mayoral; Amalia Fernández-Martínez; Lisardo Boscá; Paloma Martín-Sanz
Prostaglandin E2 promotes migration and adhesion in hepatocellular carcinoma cells.
Carcinogenesis 2005;26(4):753-61.
2005: Lisardo Boscá; Miriam Zeini; Paqui G Través; Sonsoles Hortelano
Nitric oxide and cell viability in inflammatory cells: a role for NO in macrophage function and fate.
Toxicology 2005;208(2):249-58.
2005: Sonsoles Hortelano; Miriam Zeini; Paqui G Través; Lisardo Boscá
Nitric oxide and cell signaling: in vivo evaluation of NO-dependent apoptosis by MRI and not NMR techniques.
Methods in enzymology 2005;396():579-84.
2005: Ta-Hsiang Chao; Thanh Lam; Binh G Vong; Paqui G Través; Sonsoles Hortelano; Chinmay Chowdhury; Frances Bahjat; G Kenneth Lloyd; Lyle L Moldawer; Lisardo Boscá; Michael A Palladino; Emmanuel A Theodorakis
A new family of synthetic diterpenes that regulates cytokine synthesis by inhibiting IkappaBalpha phosphorylation.
Chembiochem : a European journal of chemical biology 2005;6(1):133-44.
2004: Emilio Siendones; Dalia Fouad; María José M Díaz-Guerra; Manuel De la Mata; Lisardo Boscá; Jordi Muntané
PGE1-induced NO reduces apoptosis by D-galactosamine through attenuation of NF-kappaB and NOS-2 expression in rat hepatocytes.
Hepatology (Baltimore, Md.) 2004;40(6):1295-303.
2004: Nora Goren; Jimena Cuenca; Paloma Martín-Sanz; Lisardo Boscá
Attenuation of NF-kappaB signalling in rat cardiomyocytes at birth restricts the induction of inflammatory genes.
Cardiovascular research 2004;64(2):289-97.
2004: Oscar Núñez; Amalia Fernández-Martínez; Pedro Majano; Arantxa Apolinario; Marta Gómez-Gonzalo; Ignacio Benedicto; Manuel López-Cabrera; Lisardo Boscá; Gerardo Clemente; Carmelo García-Monzón; Paloma Martín-Sanz
Increased intrahepatic cyclooxygenase 2, matrix metalloproteinase 2, and matrix metalloproteinase 9 expression is associated with progressive liver disease in chronic hepatitis C virus infection: role of viral core and NS5A proteins.
Gut 2004;53(11):1665-72.
2004: José Luis Oliva; Natasha Zarich; Natalia Martínez; Rocío Jorge; Antonio Castrillo; Marta Azañedo; Susana García-Vargas; Silvia Gutiérrez-Eisman; Angeles Juarranz; Lisardo Boscá; J Silvio Gutkind; José M Rojas
The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras.
The Journal of biological chemistry 2004;279(32):33480-91.
2004: Amalia Fernández-Martínez; Nuria A Callejas; Marta Casado; Lisardo Boscá; Paloma Martín-Sanz
Thioacetamide-induced liver regeneration involves the expression of cyclooxygenase 2 and nitric oxide synthase 2 in hepatocytes.
Journal of hepatology 2004;40(6):963-70.
2004: Miriam Zeini; Sonsoles Hortelano; Paqui G Través; Paloma Martín-Sanz; Lisardo Boscá
Simultaneous abrogation of NOS-2 and COX-2 activities is lethal in partially hepatectomised mice.
Journal of hepatology 2004;40(6):926-33.
2004: Inmaculada Navarro-Lérida; M Teresa Portolés; Alberto Alvarez Barrientos; Francisco Gavilanes; Lisardo Boscá; Ignacio Rodríguez-Crespo
Induction of nitric oxide synthase-2 proceeds with the concomitant downregulation of the endogenous caveolin levels.
Journal of cell science 2004;117(Pt 9):1687-97.
2003: Sonsoles Hortelano; Paqui G Través; Miriam Zeini; Alberto M Alvarez; Lisardo Boscá
Sustained nitric oxide delivery delays nitric oxide-dependent apoptosis in macrophages: contribution to the physiological function of activated macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):6059-64.
2003: María Fernández-Velasco; Nora Goren; Gemma Benito; Javier Blanco-Rivero; Lisardo Boscá; Carmen Delgado
Regional distribution of hyperpolarization-activated current (If) and hyperpolarization-activated cyclic nucleotide-gated channel mRNA expression in ventricular cells from control and hypertrophied rat hearts.
The Journal of physiology 2003;553(Pt 2):395-405.
2003: José L M Madrigal; Maria Moro; ignacio lizasoain; Pedro Lorenzo; Ana Patricia Fernández; José Rodrigo; Lisardo Boscá; Juan C Leza
Induction of cyclooxygenase-2 accounts for restraint stress-induced oxidative status in rat brain.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(9):1579-88.
2003: José Luis Oliva; Dolores Pérez-Sala; Antonio Castrillo; Natalia Martínez; F Javier Cañada; Lisardo Boscá; José M Rojas
The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(8):4772-7.
2003: Nuria A Callejas; Amalia Fernández-Martínez; Antonio Castrillo; Lisardo Boscá; Paloma Martín-Sanz
Selective inhibitors of cyclooxygenase-2 delay the activation of nuclear factor kappa B and attenuate the expression of inflammatory genes in murine macrophages treated with lipopolysaccharide.
Molecular pharmacology 2003;63(3):671-7.
2003: Antonio Castrillo; Paqui G Través; Paloma Martín-Sanz; Scott Parkinson; Peter J Parker; Lisardo Boscá
Potentiation of protein kinase C zeta activity by 15-deoxy-delta(12,14)-prostaglandin J(2) induces an imbalance between mitogen-activated protein kinases and NF-kappa B that promotes apoptosis in macrophages.
Molecular and cellular biology 2003;23(4):1196-208.
2003: Olga Millán; Alicia Ballester; Antonio Castrillo; José Luis Oliva; Paqui G Través; José M Rojas; Lisardo Boscá
H-Ras-specific activation of NF-kappaB protects NIH 3T3 cells against stimulus-dependent apoptosis.
Oncogene 2003;22(4):477-83.
2003: B de las Heras; B Rodríguez; Lisardo Boscá; Angel M Villar
Terpenoids: sources, structure elucidation and therapeutic potential in inflammation.
Current topics in medicinal chemistry 2003;3(2):171-85.
2003: Paloma Martín-Sanz; Luis Olmedilla; Elena Dulin; Marta Casado; Nuria A Callejas; José Pérez-Peña; Ignacio Garutti; Javier Sanz; Javier Calleja; Santos Barrigón; Lisardo Boscá
Presence of methylated arginine derivatives in orthotopic human liver transplantation: relevance for liver function.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2003;9(1):40-8.
2002: Paloma Martin-Sanz; Sonsoles Hortelano; Nuria A Callejas; Nora Goren; Marta Casado; Miriam Zeini; Lisardo Boscá
Nitric oxide in liver inflammation and regeneration.
Metabolic brain disease 2002;17(4):325-34.
2002: Eduardo Molina-Holgado; Angel Arévalo-Martín; Antonio Castrillo; Lisardo Boscá; José Miguel Vela; Carmen Guaza
Interleukin-4 and interleukin-10 modulate nuclear factor kappaB activity and nitric oxide synthase-2 expression in Theiler's virus-infected brain astrocytes.
Journal of neurochemistry 2002;81(6):1242-52.
2002: Sonsoles Hortelano; Miriam Zeini; Antonio Castrillo; Alberto M Alvarez; Lisardo Boscá
Induction of apoptosis by nitric oxide in macrophages is independent of apoptotic volume decrease.
Cell death and differentiation 2002;9(6):643-50.
2002: Nuria A Callejas; Marta Casado; Lisardo Boscá; Paloma Martín-Sanz
Absence of nuclear factor kappaB inhibition by NSAIDs in hepatocytes.
Hepatology (Baltimore, Md.) 2002;35(2):341-8.
2002: José L M Madrigal; Olivia Hurtado; Maria Moro; ignacio lizasoain; Pedro Lorenzo; Antonio Castrillo; Lisardo Boscá; Juan C Leza
The increase in TNF-alpha levels is implicated in NF-kappaB activation and inducible nitric oxide synthase expression in brain cortex after immobilization stress.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2002;26(2):155-63.
2002: Sonsoles Hortelano; Miriam Zeini; Lisardo Boscá
Nitric oxide and resolution of inflammation.
Methods in enzymology 2002;359():459-65.
2002: David Alonso; Juan Manuel Encinas; L Otto Uttenthal; Lisardo Boscá; Julia Serrano; Ana Patricia Fernández; Susana Castro-Blanco; María Santacana; María Luisa Bentura; Ana Richart; Paula Fernández-Vizarra; José Rodrigo
Coexistence of translocated cytochrome c and nitrated protein in neurons of the rat cerebral cortex after oxygen and glucose deprivation.
Neuroscience 2002;111(1):47-56.
2001: Antonio Castrillo; D J Pennington; F Otto; P J Parker; M J Owen; Lisardo Boscá
Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection.
The Journal of experimental medicine 2001;194(9):1231-42.
2001: Sonsoles Hortelano; María L García-Martín; Sebastián Cerdán; Antonio Castrillo; Alberto M Alvarez; Lisardo Boscá
Intracellular water motion decreases in apoptotic macrophages after caspase activation.
Cell death and differentiation 2001;8(10):1022-8.
2001: Antonio Castrillo; M Mojena; Sonsoles Hortelano; Lisardo Boscá
Peroxisome proliferator-activated receptor-gamma-independent inhibition of macrophage activation by the non-thiazolidinedione agonist L-796,449. Comparison with the effects of 15-deoxy-delta(12,14)-prostaglandin J(2).
The Journal of biological chemistry 2001;276(36):34082-8.
2001: Marta Casado; Nuria A Callejas; J Rodrigo; X Zhao; S K Dey; Lisardo Boscá; Paloma Martín-Sanz
Contribution of cyclooxygenase 2 to liver regeneration after partial hepatectomy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(11):2016-8.
2001: Olivia Hurtado; Antonio Cárdenas; ignacio lizasoain; Lisardo Boscá; Juan C Leza; Pedro Lorenzo; Maria Moro
Up-regulation of TNF-alpha convertase (TACE/ADAM17) after oxygen-glucose deprivation in rat forebrain slices.
Neuropharmacology 2001;40(8):1094-102.
2001: Nuria A Callejas; Marta Casado; María José M Díaz-Guerra; Lisardo Boscá; Paloma Martín-Sanz
Expression of cyclooxygenase-2 promotes the release of matrix metalloproteinase-2 and -9 in fetal rat hepatocytes.
Hepatology (Baltimore, Md.) 2001;33(4):860-7.
2001: José L M Madrigal; Maria Moro; ignacio lizasoain; Pedro Lorenzo; Antonio Castrillo; Lisardo Boscá; Juan C Leza
Inducible nitric oxide synthase expression in brain cortex after acute restraint stress is regulated by nuclear factor kappaB-mediated mechanisms.
Journal of neurochemistry 2001;76(2):532-8.
2000: Sonsoles Hortelano; Antonio Castrillo; Alberto M Alvarez; Lisardo Boscá
Contribution of cyclopentenone prostaglandins to the resolution of inflammation through the potentiation of apoptosis in activated macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6525-31.
2000: Nuria A Callejas; Lisardo Boscá; Christopher Williams; Raymond DuBois; Paloma Martín-Sanz
Regulation of cyclooxygenase 2 expression in hepatocytes by CCAAT/enhancer-binding proteins.
Gastroenterology 2000;119(2):493-501.
2000: Lisardo Boscá; OG Bodelón; Sonsoles Hortelano; A Casellas; F Bosch
Anti-inflammatory action of type I interferons deduced from mice expressing interferon beta.
Gene therapy 2000;7(10):817-25.
2000: Antonio Cárdenas; Maria Moro; Olivia Hurtado; Juan C Leza; Pedro Lorenzo; Antonio Castrillo; OG Bodelón; Lisardo Boscá; ignacio lizasoain
Implication of glutamate in the expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slices.
Journal of neurochemistry 2000;74(5):2041-8.
2000: Maria Moro; J De Alba; Antonio Cárdenas; Javier De Cristóbal; Juan C Leza; ignacio lizasoain; María José M Díaz-Guerra; Lisardo Boscá; Pedro Lorenzo
Mechanisms of the neuroprotective effect of aspirin after oxygen and glucose deprivation in rat forebrain slices.
Neuropharmacology 2000;39(7):1309-18.
2000: Antonio Castrillo; María José M Díaz-Guerra; Sonsoles Hortelano; Paloma Martín-Sanz; Lisardo Boscá
Inhibition of IkappaB kinase and IkappaB phosphorylation by 15-deoxy-Delta(12,14)-prostaglandin J(2) in activated murine macrophages.
Molecular and cellular biology 2000;20(5):1692-8.
2000: Antonio Castrillo; OG Bodelón; Lisardo Boscá
Inhibitory effect of IGF-I on type 2 nitric oxide synthase expression in Ins-1 cells and protection against activation-dependent apoptosis: involvement of phosphatidylinositol 3-kinase.
Diabetes 2000;49(2):209-17.
2000: R Olivenza; Maria Moro; ignacio lizasoain; Pedro Lorenzo; Ana Patricia Fernández; J Rodrigo; Lisardo Boscá; Juan C Leza
Chronic stress induces the expression of inducible nitric oxide synthase in rat brain cortex.
Journal of neurochemistry 2000;74(2):785-91.
1999: Sonsoles Hortelano; Alberto M Alvarez; Lisardo Boscá
Nitric oxide induces tyrosine nitration and release of cytochrome c preceding an increase of mitochondrial transmembrane potential in macrophages.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(15):2311-7.
1999: B de las Heras; A Navarro; María José M Díaz-Guerra; Paulina Bermejo; Antonio Castrillo; Lisardo Boscá; A Villar
Inhibition of NOS-2 expression in macrophages through the inactivation of NF-kappaB by andalusol.
British journal of pharmacology 1999;128(3):605-12.
1999: Nuria A Callejas; Marta Casado; Lisardo Boscá; Paloma Martín-Sanz
Requirement of nuclear factor kappaB for the constitutive expression of nitric oxide synthase-2 and cyclooxygenase-2 in rat trophoblasts.
Journal of cell science 1999;112 Pt 18():3147-55.
1999: Paloma Martín-Sanz; Lisardo Boscá; Luis Olmedilla; Jose M Perez-Peña; Ignacio Garutti; Javier Sanz; Javier Calleja; Martin Avellanal; Ana Ortega; Amaya Aleixandre; Santos Barrigón
Presence of a nitric oxide synthase inhibitor in the graft efflux during reperfusion in human liver transplantation.
Clinical transplantation 1999;13(3):221-30.
1999: María José M Díaz-Guerra; Antonio Castrillo; Paloma Martín-Sanz; Lisardo Boscá
Negative regulation by protein tyrosine phosphatase of IFN-gamma-dependent expression of inducible nitric oxide synthase.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(11):6776-83.
1999: María José M Díaz-Guerra; Antonio Castrillo; Paloma Martín-Sanz; Lisardo Boscá
Negative regulation by phosphatidylinositol 3-kinase of inducible nitric oxide synthase expression in macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):6184-90.
1999: Lisardo Boscá; Sonsoles Hortelano
Mechanisms of nitric oxide-dependent apoptosis: involvement of mitochondrial mediators.
Cellular signalling 1999;11(4):239-44.
1999: Sonsoles Hortelano; Eduardo López-Collazo; Lisardo Boscá
Protective effect of cyclosporin A and FK506 from nitric oxide-dependent apoptosis in activated macrophages.
British journal of pharmacology 1999;126(5):1139-46.
1999: Nuria A Callejas; Antonio Castrillo; Lisardo Boscá; Paloma Martín-Sanz
Inhibition of prostaglandin synthesis up-regulates cyclooxygenase-2 induced by lipopolysaccharide and peroxisomal proliferators.
The Journal of pharmacology and experimental therapeutics 1999;288(3):1235-41.
1999: J De Alba; Antonio Cárdenas; Maria Moro; Juan C Leza; Pedro Lorenzo; Lisardo Boscá; ignacio lizasoain
Down-regulation of neuronal nitric oxide synthase by nitric oxide after oxygen-glucose deprivation in rat forebrain slices.
Journal of neurochemistry 1999;72(1):248-54.
1998: Paloma Martín-Sanz; Nuria A Callejas; Marta Casado; María José M Díaz-Guerra; Lisardo Boscá
Expression of cyclooxygenase-2 in foetal rat hepatocytes stimulated with lipopolysaccharide and pro-inflammatory cytokines.
British journal of pharmacology 1998;125(6):1313-9.
1998: Eduardo López-Collazo; Sonsoles Hortelano; Lisardo Boscá
Interferon-alpha/beta inhibits the apoptosis induced by lipopolysaccharide and interferon-gamma in murine peritoneal macrophages.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1998;18(7):461-7.
1998: S Llanos; Carme Caelles; Inmaculada Azorín; Jaime Renau-Piqueras; J L Fernández-Luna; Lisardo Boscá; Alberto Muñoz
The c-erbA alpha protooncogene induces apoptosis in glial cells via a protein kinase C- and bcl-2-suppressible mechanism.
Journal of neurochemistry 1998;70(6):2315-26.
1998: Eduardo López-Collazo; Sonsoles Hortelano; Armando Rojas; Lisardo Boscá
Triggering of peritoneal macrophages with IFN-alpha/beta attenuates the expression of inducible nitric oxide synthase through a decrease in NF-kappaB activation.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(6):2889-95.
1998: Maria Moro; J De Alba; Juan C Leza; Pedro Lorenzo; Ana Patricia Fernández; María Luisa Bentura; Lisardo Boscá; José Rodrigo; ignacio lizasoain
Neuronal expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slices.
The European journal of neuroscience 1998;10(2):445-56.
1997: Marta Casado; María José M Díaz-Guerra; Lisardo Boscá; Paloma Martín-Sanz
Differential regulation of nitric oxide synthase mRNA expression by lipopolysaccharide and pro-inflammatory cytokines in fetal hepatocytes treated with cycloheximide.
The Biochemical journal 1997;327 ( Pt 3)():819-23.
1997: María José M Díaz-Guerra; M Velasco; Paloma Martín-Sanz; Lisardo Boscá
Nuclear factor kappaB is required for the transcriptional control of type II NO synthase in regenerating liver.
The Biochemical journal 1997;326 ( Pt 3)():791-7.
1997: M Velasco; María José M Díaz-Guerra; Paloma Martín-Sanz; A Alvarez; Lisardo Boscá
Rapid Up-regulation of IkappaBbeta and abrogation of NF-kappaB activity in peritoneal macrophages stimulated with lipopolysaccharide.
The Journal of biological chemistry 1997;272(37):23025-30.
1997: Eduardo López-Collazo; Jesus Mateo; M Teresa Miras-Portugal; Lisardo Boscá
Requirement of nitric oxide and calcium mobilization for the induction of apoptosis in adrenal vascular endothelial cells.
FEBS letters 1997;413(1):124-8.
1997: Carmen Díez-Fernández; Nuria Sanz; Lisardo Boscá; Sonsoles Hortelano; María Cascales
Involvement of nitric oxide synthesis in hepatic perturbations induced in rats by a necrogenic dose of thioacetamide.
British journal of pharmacology 1997;121(4):820-6.
1997: Marta Casado; M Velasco; Lisardo Boscá; Paloma Martín-Sanz
Absence of NO synthase type II expression in fetal liver from pregnant rats under septic shock conditions.
Hepatology (Baltimore, Md.) 1997;25(6):1406-11.
1997: Marta Casado; M J D-iaz-Guerra; J Rodrigo; A P Fernández; Lisardo Boscá; Paloma Martín-Sanz
Expression of the calcium-independent cytokine-inducible (iNOS) isoform of nitric oxide synthase in rat placenta.
The Biochemical journal 1997;324 ( Pt 1)():201-7.
1997: M Velasco; María José M Díaz-Guerra; P Díaz-Achirica; David Andreu; L Rivas; Lisardo Boscá
Macrophage triggering with cecropin A and melittin-derived peptides induces type II nitric oxide synthase expression.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(9):4437-43.
1997: Sonsoles Hortelano; Lisardo Boscá
6-Mercaptopurine decreases the Bcl-2/Bax ratio and induces apoptosis in activated splenic B lymphocytes.
Molecular pharmacology 1997;51(3):414-21.
1997: Matías A Avila; J Mingorance; María L Martínez-Chantar; Marta Casado; P Martin-Sanz; Lisardo Boscá; José M Mato
Regulation of rat liver S-adenosylmethionine synthetase during septic shock: role of nitric oxide.
Hepatology (Baltimore, Md.) 1997;25(2):391-6.
1997: Sonsoles Hortelano; María José M Díaz-Guerra; A Gonzalez-García; Esther Leonardo; C Gamallo; Lisardo Boscá; Carlos Martínez-A
Linomide administration to mice attenuates the induction of nitric oxide synthase elicited by lipopolysaccharide-activated macrophages and prevents nephritis in MRL/Mp-lpr/lpr mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1402-8.
1996: María José M Díaz-Guerra; O G Bodelón; M Velasco; R Whelan; P J Parker; Lisardo Boscá
Up-regulation of protein kinase C-epsilon promotes the expression of cytokine-inducible nitric oxide synthase in RAW 264.7 cells.
The Journal of biological chemistry 1996;271(50):32028-33.
1996: María José M Díaz-Guerra; M Velasco; Paloma Martín-Sanz; Lisardo Boscá
Evidence for common mechanisms in the transcriptional control of type II nitric oxide synthase in isolated hepatocytes. Requirement of NF-kappaB activation after stimulation with bacterial cell wall products and phorbol esters.
The Journal of biological chemistry 1996;271(47):30114-20.
1996: B Gil; Marta Casado; María Angeles Pajares; Lisardo Boscá; José M Mato; Paloma Martín-Sanz; L Alvarez
Differential expression pattern of S-adenosylmethionine synthetase isoenzymes during rat liver development.
Hepatology (Baltimore, Md.) 1996;24(4):876-81.
1996: Paloma Martín-Sanz; María José M Díaz-Guerra; Marta Casado; Lisardo Boscá
Bacterial lipopolysaccharide antagonizes transforming growth factor beta 1-induced apoptosis in primary cultures of hepatocytes.
Hepatology (Baltimore, Md.) 1996;23(5):1200-7.
1996: Marta Casado; Lisardo Boscá; Paloma Martín-Sanz
Multiple forms of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase are expressed in perinatal rat liver.
The American journal of physiology 1996;270(2 Pt 1):E244-50.
1995: Marta Casado; Lisardo Boscá; Paloma Martín-Sanz
Differential regulation of the expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and pyruvate kinase by cyclic adenosine 3',5'-monophosphate in fetal and adult hepatocytes.
Journal of cellular physiology 1995;165(3):630-8.
1995: F Terenzi; Marta Casado; Paloma Martín-Sanz; Lisardo Boscá
Epidermal growth factor inhibits cytokine-dependent nitric oxide synthase expression in hepatocytes.
FEBS letters 1995;368(1):193-6.
1995: Ana María Genaro; Sonsoles Hortelano; A Alvarez; Carlos Martínez; Lisardo Boscá
Splenic B lymphocyte programmed cell death is prevented by nitric oxide release through mechanisms involving sustained Bcl-2 levels.
The Journal of clinical investigation 1995;95(4):1884-90.
1995: F Terenzi; María José M Díaz-Guerra; Marta Casado; Sonsoles Hortelano; S Leoni; Lisardo Boscá
Bacterial lipopeptides induce nitric oxide synthase and promote apoptosis through nitric oxide-independent pathways in rat macrophages.
The Journal of biological chemistry 1995;270(11):6017-21.
1995: Sonsoles Hortelano; B Dewez; Ana María Genaro; María José M Díaz-Guerra; Lisardo Boscá
Nitric oxide is released in regenerating liver after partial hepatectomy.
Hepatology (Baltimore, Md.) 1995;21(3):776-86.
1994: María Jesús Oset-Gasque; M Parramón; Sonsoles Hortelano; Lisardo Boscá; María Pilar González
Nitric oxide implication in the control of neurosecretion by chromaffin cells.
Journal of neurochemistry 1994;63(5):1693-700.
1994: María Cascales; A Alvarez; P Gascó; L Fernández-Simón; Nuria Sanz; Lisardo Boscá
Cocaine-induced liver injury in mice elicits specific changes in DNA ploidy and induces programmed death of hepatocytes.
Hepatology (Baltimore, Md.) 1994;20(4 Pt 1):992-1001.
1994: Lisardo Boscá; P A Lazo
Induction of nitric oxide release by MRC OX-44 (anti-CD53) through a protein kinase C-dependent pathway in rat macrophages.
The Journal of experimental medicine 1994;179(4):1119-26.
1993: Carmen Díez-Fernández; Lisardo Boscá; L Fernández-Simón; A Alvarez; María Cascales
Relationship between genomic DNA ploidy and parameters of liver damage during necrosis and regeneration induced by thioacetamide.
Hepatology (Baltimore, Md.) 1993;18(4):912-8.
1993: Marta Casado; Lisardo Boscá; Paloma Martín-Sanz
Rat liver messenger ribonucleic acid and enzyme activity of 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase impairment during the late period of pregnancy.
Endocrinology 1993;133(3):1044-50.
1993: Ana María Genaro; Lisardo Boscá
Early signals in alloantigen induced B-cell proliferation. Comparison between B-cell triggering by intact allogeneic cells and solubilized alloantigen.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(4):1832-43.
1993: L López-Alarcón; E Melián; M J Muñoz-Alonso; Carlos Guijarro; Lisardo Boscá; Juan E Felíu
Sulfonylureas activate glycogen phosphorylase and increase cytosolic free-Ca2+ levels in isolated rat hepatocytes.
Metabolism: clinical and experimental 1993;42(5):624-30.
1993: Sonsoles Hortelano; Ana María Genaro; Lisardo Boscá
Phorbol esters induce nitric oxide synthase and increase arginine influx in cultured peritoneal macrophages.
FEBS letters 1993;320(2):135-9.
1993: E Baixeras; Guido Kroemer; E Cuende; C Márquez; Lisardo Boscá; J E Alés Martínez; Carlos Martínez
Signal transduction pathways involved in B-cell induction.
Immunological reviews 1993;132():5-47.
1993: Lisardo Boscá; F Morán
Circular dichroism analysis of ligand-induced conformational changes in protein kinase C. Mechanism of translocation of the enzyme from the cytosol to the membranes and its implications.
The Biochemical journal 1993;290 ( Pt 3)():827-32.
1993: M Junco; María José M Díaz-Guerra; Lisardo Boscá
Differential calcium mobilization by vasopressin, angiotensin II, gastrin-releasing peptide, and adenosine triphosphate in adult and fetal hepatocytes. Relevance for the activation of calcium-dependent enzymes.
Endocrinology 1993;132(1):309-18.
1992: Sonsoles Hortelano; Ana María Genaro; Lisardo Boscá
Phorbol esters induce nitric oxide synthase activity in rat hepatocytes. Antagonism with the induction elicited by lipopolysaccharide.
The Journal of biological chemistry 1992;267(35):24937-40.
1992: María Cascales; P Martin-Sanz; A Alvarez; M Sanchez-Pérez; C Diez Fernández; Lisardo Boscá
Isoenzymes of carbohydrate metabolism in primary cultures of hepatocytes from thioacetamide-induced rat liver necrosis: responses to growth factors.
Hepatology (Baltimore, Md.) 1992;16(1):232-40.
1992: Paloma Martín-Sanz; María Cascales; Lisardo Boscá
Characterization of 6-phosphofructo-2-kinase from foetal-rat liver.
The Biochemical journal 1992;281 ( Pt 2)():457-63.
1991: María José M Díaz-Guerra; M Junco; Lisardo Boscá
Oleic acid promotes changes in the subcellular distribution of protein kinase C in isolated hepatocytes.
The Journal of biological chemistry 1991;266(35):23568-76.
1991: Lisardo Boscá; C Márquez; Carlos Martínez
B cell triggering by bacterial lipopeptide involves both translocation and activation of the membrane-bound form of protein kinase C.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(5):1463-9.
1991: C Márquez; Carlos Martínez; Lisardo Boscá
Protein kinase C mobilization in B lymphocytes. Differential isoenzyme translocation upon activation.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(2):627-32.
1990: María José M Díaz-Guerra; Lisardo Boscá
Lack of translocation of protein kinase C from the cytosol to the membranes in vasopressin-stimulated hepatocytes.
The Biochemical journal 1990;269(1):163-8.
1990: M Junco; María José M Díaz-Guerra; Lisardo Boscá
Substrate-dependent inhibition of protein kinase C by specific inhibitors.
FEBS letters 1990;263(1):169-71.
1989: M Mojena; Lisardo Boscá
Identification of an anti-A and anti-B blood group glycosyltransferase antibody after incompatible bone marrow transplant.
Blood 1989;74(3):1134-8.
1989: Lisardo Boscá; María José M Díaz-Guerra; M Mojena
Oleate-induced translocation of protein kinase C to hepatic microsomal membranes.
Biochemical and biophysical research communications 1989;160(3):1243-9.
1989: C Cascales; Lisardo Boscá; Paloma Martín-Sanz; D N Brindley; María Cascales
Translocation of phosphatidate phosphohydrolase from the cytosol to microsomal membranes in thioacetamide-induced liver tumours in rats.
Toxicology letters 1989;47(1):9-16.
1989: P Martin-Sanz; María Cascales; Lisardo Boscá
Glucagon-induced changes in fructose 2,6-bisphosphate and 6-phosphofructo-2-kinase in cultured rat foetal hepatocytes.
The Biochemical journal 1989;257(3):795-9.
1988: L Barbolla; M Mojena; Lisardo Boscá
Presence of antibody to A- and B-transferases in minor incompatible bone marrow transplant.
British journal of haematology 1988;70(4):471-6.
1988: C Cascales; Lisardo Boscá; A Martin; D N Brindley; María Cascales
Age-related changes in the translocation of phosphatidate phosphohydrolase from the cytosol to microsomal membranes in rat liver.
Biochimica et biophysica acta 1988;963(2):384-8.
1988: Lisardo Boscá; María José M Díaz-Guerra
Activation of protein kinase C from B lymphocytes by lipid A.
Biochemical and biophysical research communications 1988;152(1):149-54.
1987: Paloma Martín-Sanz; María Cascales; Lisardo Boscá
Fructose 2,6-bisphosphate in isolated foetal hepatocytes.
FEBS letters 1987;225(1-2):37-42.