Lisardo Boscá

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Inserte Javier; Molla Belén; Aguilar Rio; Través Paqui G; Barba Ignasi; Martín-Sanz Paloma; Boscá Lisardo; Casado Marta; Garcia-Dorado David
Constitutive COX-2 activity in cardiomyocytes confers permanent cardioprotection Constitutive COX-2 expression and cardioprotection.
Mayoral Rafael; Mollá Belen; Flores Juana Maria; Boscá Lisardo; Casado Marta; Martín-Sanz Paloma
Constitutive expression of cyclo-oxygenase 2 transgene in hepatocytes protects against liver injury.
Girón Natalia; Través Paqui G; Rodríguez Benjamín; López-Fontal Raquel; Boscá Lisardo; Hortelano Sonsoles; de las Heras Beatriz
Suppression of inflammatory responses by labdane-type diterpenoids.

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All Publications

2009: Inserte Javier; Molla Belén; Aguilar Rio; Través Paqui G; Barba Ignasi; Martín-Sanz Paloma; Boscá Lisardo; Casado Marta; Garcia-Dorado David
Constitutive COX-2 activity in cardiomyocytes confers permanent cardioprotection Constitutive COX-2 expression and cardioprotection.
Journal of molecular and cellular cardiology 2009;46(2):160-8.
2008: Mayoral Rafael; Mollá Belen; Flores Juana Maria; Boscá Lisardo; Casado Marta; Martín-Sanz Paloma
Constitutive expression of cyclo-oxygenase 2 transgene in hepatocytes protects against liver injury.
The Biochemical journal 2008;416(3):337-46.
2008: Girón Natalia; Través Paqui G; Rodríguez Benjamín; López-Fontal Raquel; Boscá Lisardo; Hortelano Sonsoles; de las Heras Beatriz
Suppression of inflammatory responses by labdane-type diterpenoids.
Toxicology and applied pharmacology 2008;228(2):179-89.
2007: Cuenca Jimena; Goren Nora; Prieto Patricia; Martín-Sanz Paloma; Boscá Lisardo
Selective impairment of nuclear factor-kappaB-dependent gene transcription in adult cardiomyocytes: relevance for the regulation of the inflammatory response in the heart.
The American journal of pathology 2007;171(3):820-8.
2007: Mayoral Rafael; Fernández-Martínez Amalia; Roy Rosa; Boscá Lisardo; Martín-Sanz Paloma
Dispensability and dynamics of caveolin-1 during liver regeneration and in isolated hepatic cells.
Hepatology (Baltimore, Md.) 2007;46(3):813-22.
2007: de las Heras B; Hortelano S; Girón N; Bermejo P; Rodríguez B; Boscá L
Kaurane diterpenes protect against apoptosis and inhibition of phagocytosis in activated macrophages.
British journal of pharmacology 2007;152(2):249-55.
2007: de Prada Teresa Pérez; Pozzi Aranzazu Ortega; Coronado Mónica Torres; Pounchard Marie Anne; Gonzalez Pablo; Boscá Lisardo; Fantidis Panayotis
Atherogenesis takes place in cholesterol-fed rabbits when circulating concentrations of endogenous cortisol are increased and inflammation suppressed.
Atherosclerosis 2007;191(2):333-9.
2007: Lombardo Eleuterio; Alvarez-Barrientos Alberto; Maroto Beatriz; Boscá Lisardo; Knaus Ulla G
TLR4-mediated survival of macrophages is MyD88 dependent and requires TNF-alpha autocrine signalling.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3731-9.
2007: Casado Marta; Mollá Belén; Roy Rosa; Fernández-Martínez Amalia; Cucarella Carme; Mayoral Rafael; Boscá Lisardo; Martín-Sanz Paloma
Protection against Fas-induced liver apoptosis in transgenic mice expressing cyclooxygenase 2 in hepatocytes.
Hepatology (Baltimore, Md.) 2007;45(3):631-8.
2007: Rico Daniel; Vaquerizas Juan M; Dopazo Hernán; Boscá Lisardo
Identification of conserved domains in the promoter regions of nitric oxide synthase 2: implications for the species-specific transcription and evolutionary differences.
BMC genomics 2007;8():271.
2007: Hortelano Sonsoles; Zeini Miriam; Casado Marta; Martín-Sanz Paloma; Boscá Lisardo
Animal models for the study of liver regeneration: role of nitric oxide and prostaglandins.
Frontiers in bioscience : a journal and virtual library 2007;12():13-21.
2006: Cuenca Jimena; Martín-Sanz Paloma; Alvarez-Barrientos Alberto M; Boscá Lisardo; Goren Nora
Infiltration of inflammatory cells plays an important role in matrix metalloproteinase expression and activation in the heart during sepsis.
The American journal of pathology 2006;169(5):1567-76.
2006: Zeini Miriam; Través Paqui G; López-Fontal Raquel; Pantoja Cristina; Matheu Ander; Serrano Manuel; Boscá Lisardo; Hortelano Sonsoles
Specific contribution of p19(ARF) to nitric oxide-dependent apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):3327-36.
2006: Fernández-Martínez Amalia; Mollá Belén; Mayoral Rafael; Boscá Lisardo; Casado Marta; Martín-Sanz Paloma
Cyclo-oxygenase 2 expression impairs serum-withdrawal-induced apoptosis in liver cells.
The Biochemical journal 2006;398(3):371-80.
2006: Millán Olga; Rico Daniel; Peinado Héctor; Zarich Natasha; Stamatakis Konstantinos; Pérez-Sala Dolores; Rojas José M; Cano Amparo; Boscá Lisardo
Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis.
Carcinogenesis 2006;27(2):328-36.
2006: Pereira Marta P; Hurtado Olivia; Cárdenas Antonio; Boscá Lisardo; Castillo José; Dávalos Antoni; Vivancos José; Serena Joaquín; Lorenzo Pedro; Lizasoain Ignacio; Moro María A
Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006;26(2):218-29.
2006: Fernandez-Pascual Mercedes; Lucas M Mercedes; de Felipe Maria Rosario; Boscá Lisardo; Hirt Heribert; Golvano Maria Pilar
Involvement of mitogen-activated protein kinases in the symbiosis Bradyrhizobium-Lupinus.
Journal of experimental botany 2006;57(11):2735-42.
2005: Pereira Marta P; Hurtado Olivia; Cárdenas Antonio; Alonso-Escolano David; Boscá Lisardo; Vivancos José; Nombela Florentino; Leza Juan C; Lorenzo Pedro; Lizasoain Ignacio; Moro María A
The nonthiazolidinedione PPARgamma agonist L-796,449 is neuroprotective in experimental stroke.
Journal of neuropathology and experimental neurology 2005;64(9):797-805.
2005: Boscá Lisardo; Lamas Santiago; Redondo Juan Miguel
Madrid center not quite in limbo.
Science (New York, N.Y.) 2005;309(5737):1017.
2005: Zeini Miriam; Hortelano Sonsoles; Través Paqui G; Gómez-Valadés Alicia G; Pujol Anna; Perales José C; Bartrons Ramón; Boscá Lisardo
Assessment of a dual regulatory role for NO in liver regeneration after partial hepatectomy: protection against apoptosis and retardation of hepatocyte proliferation.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(8):995-7.
2005: Mayoral Rafael; Fernández-Martínez Amalia; Boscá Lisardo; Martín-Sanz Paloma
Prostaglandin E2 promotes migration and adhesion in hepatocellular carcinoma cells.
Carcinogenesis 2005;26(4):753-61.
2005: Boscá Lisardo; Zeini Miriam; Través Paqui G; Hortelano Sonsoles
Nitric oxide and cell viability in inflammatory cells: a role for NO in macrophage function and fate.
Toxicology 2005;208(2):249-58.
2005: Chao Ta-Hsiang; Lam Thanh; Vong Binh G; Través Paqui G; Hortelano Sonsoles; Chowdhury Chinmay; Bahjat F Rena; Lloyd G Kenneth; Moldawer Lyle L; Boscá Lisardo; Palladino Michael A; Theodorakis Emmanuel A
A new family of synthetic diterpenes that regulates cytokine synthesis by inhibiting IkappaBalpha phosphorylation.
Chembiochem : a European journal of chemical biology 2005;6(1):133-44.
2005: Hortelano Sonsoles; Zeini Miriam; Través Paqui G; Boscá Lisardo
Nitric oxide and cell signaling: in vivo evaluation of NO-dependent apoptosis by MRI and not NMR techniques.
Methods in enzymology 2005;396():579-84.
2004: Siendones Emilio; Fouad Dalia; Díaz-Guerra María José M; de la Mata Manuel; Boscá Lisardo; Muntané Jordi
PGE1-induced NO reduces apoptosis by D-galactosamine through attenuation of NF-kappaB and NOS-2 expression in rat hepatocytes.
Hepatology (Baltimore, Md.) 2004;40(6):1295-303.
2004: Goren Nora; Cuenca Jimena; Martín-Sanz Paloma; Boscá Lisardo
Attenuation of NF-kappaB signalling in rat cardiomyocytes at birth restricts the induction of inflammatory genes.
Cardiovascular research 2004;64(2):289-97.
2004: Núñez O; Fernández-Martínez A; Majano P L; Apolinario A; Gómez-Gonzalo M; Benedicto I; López-Cabrera M; Boscá L; Clemente G; García-Monzón C; Martín-Sanz P
Increased intrahepatic cyclooxygenase 2, matrix metalloproteinase 2, and matrix metalloproteinase 9 expression is associated with progressive liver disease in chronic hepatitis C virus infection: role of viral core and NS5A proteins.
Gut 2004;53(11):1665-72.
2004: Oliva José Luis; Zarich Natasha; Martínez Natalia; Jorge Rocío; Castrillo Antonio; Azañedo Marta; García-Vargas Susana; Gutiérrez-Eisman Silvia; Juarranz Angeles; Boscá Lisardo; Gutkind J Silvio; Rojas José M
The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras.
The Journal of biological chemistry 2004;279(32):33480-91.
2004: Fernández-Martínez Amalia; Callejas Nuria A; Casado Marta; Boscá Lisardo; Martín-Sanz Paloma
Thioacetamide-induced liver regeneration involves the expression of cyclooxygenase 2 and nitric oxide synthase 2 in hepatocytes.
Journal of hepatology 2004;40(6):963-70.
2004: Zeini Miriam; Hortelano Sonsoles; Través Paqui G; Martín-Sanz Paloma; Boscá Lisardo
Simultaneous abrogation of NOS-2 and COX-2 activities is lethal in partially hepatectomised mice.
Journal of hepatology 2004;40(6):926-33.
2004: Navarro-Lérida Inmaculada; Portolés María Teresa; Barrientos Alberto Alvarez; Gavilanes Francisco; Boscá Lisardo; Rodríguez-Crespo Ignacio
Induction of nitric oxide synthase-2 proceeds with the concomitant downregulation of the endogenous caveolin levels.
Journal of cell science 2004;117(Pt 9):1687-97.
2003: Hortelano Sonsoles; Través Paqui G; Zeini Miriam; Alvarez Alberto M; Boscá Lisardo
Sustained nitric oxide delivery delays nitric oxide-dependent apoptosis in macrophages: contribution to the physiological function of activated macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):6059-64.
2003: Fernández-Velasco María; Goren Nora; Benito Gemma; Blanco-Rivero Javier; Boscá Lisardo; Delgado Carmen
Regional distribution of hyperpolarization-activated current (If) and hyperpolarization-activated cyclic nucleotide-gated channel mRNA expression in ventricular cells from control and hypertrophied rat hearts.
The Journal of physiology 2003;553(Pt 2):395-405.
2003: Madrigal José L M; Moro María A; Lizasoain Ignacio; Lorenzo Pedro; Fernández A Patricia; Rodrigo José; Boscá Lisardo; Leza Juan C
Induction of cyclooxygenase-2 accounts for restraint stress-induced oxidative status in rat brain.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(9):1579-88.
2003: Oliva Jose Luis; Pérez-Sala Dolores; Castrillo Antonio; Martínez Natalia; Cañada F Javier; Boscá Lisardo; Rojas José M
The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(8):4772-7.
2003: Callejas Nuria A; Fernández-Martínez Amalia; Castrillo Antonio; Boscá Lisardo; Martín-Sanz Paloma
Selective inhibitors of cyclooxygenase-2 delay the activation of nuclear factor kappa B and attenuate the expression of inflammatory genes in murine macrophages treated with lipopolysaccharide.
Molecular pharmacology 2003;63(3):671-7.
2003: Castrillo Antonio; Través Paqui G; Martín-Sanz Paloma; Parkinson Scott; Parker Peter J; Boscá Lisardo
Potentiation of protein kinase C zeta activity by 15-deoxy-delta(12,14)-prostaglandin J(2) induces an imbalance between mitogen-activated protein kinases and NF-kappa B that promotes apoptosis in macrophages.
Molecular and cellular biology 2003;23(4):1196-208.
2003: Millán Olga; Ballester Alicia; Castrillo Antonio; Oliva José Luis de la; Través Paqui G; Rojas José María; Boscá Lisardo
H-Ras-specific activation of NF-kappaB protects NIH 3T3 cells against stimulus-dependent apoptosis.
Oncogene 2003;22(4):477-83.
2003: Martín-Sanz Paloma; Olmedilla Luis; Dulin Elena; Casado Marta; Callejas Nuria A; Pérez-Peña José; Garutti Ignacio; Sanz Javier; Calleja Javier; Barrigón Santos; Boscá Lisardo
Presence of methylated arginine derivatives in orthotopic human liver transplantation: relevance for liver function.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2003;9(1):40-8.
2003: de las Heras B; Rodríguez B; Boscá L; Villar A M
Terpenoids: sources, structure elucidation and therapeutic potential in inflammation.
Current topics in medicinal chemistry 2003;3(2):171-85.
2002: Martin-Sanz Paloma; Hortelano Sonsoles; Callejas Nuria A; Goren Nora; Casado Marta; Zeini Miriam; Boscá Lisardo
Nitric oxide in liver inflammation and regeneration.
Metabolic brain disease 2002;17(4):325-34.
2002: Molina-Holgado Eduardo; Arévalo-Martín Angel; Castrillo Antonio; Boscá Lisardo; Vela José M; Guaza Carmen
Interleukin-4 and interleukin-10 modulate nuclear factor kappaB activity and nitric oxide synthase-2 expression in Theiler's virus-infected brain astrocytes.
Journal of neurochemistry 2002;81(6):1242-52.
2002: Hortelano S; Zeini M; Castrillo A; Alvarez A M; Boscá L
Induction of apoptosis by nitric oxide in macrophages is independent of apoptotic volume decrease.
Cell death and differentiation 2002;9(6):643-50.
2002: Callejas Nuria A; Casado Marta; Boscá Lisardo; Martín-Sanz Paloma
Absence of nuclear factor kappaB inhibition by NSAIDs in hepatocytes.
Hepatology (Baltimore, Md.) 2002;35(2):341-8.
2002: Madrigal José L M; Hurtado Olivia; Moro María A; Lizasoain Ignacio; Lorenzo Pedro; Castrillo Antonio; Boscá Lisardo; Leza Juan C
The increase in TNF-alpha levels is implicated in NF-kappaB activation and inducible nitric oxide synthase expression in brain cortex after immobilization stress.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2002;26(2):155-63.
2002: Hortelano Sonsoles; Zeini Miriam; Boscá Lisardo
Nitric oxide and resolution of inflammation.
Methods in enzymology 2002;359():459-65.
2002: Alonso D; Encinas J M; Uttenthal L O; Boscá L; Serrano J; Fernández A P; Castro-Blanco S; Santacana M; Bentura M L; Richart A; Fernández-Vizarra P; Rodrigo J
Coexistence of translocated cytochrome c and nitrated protein in neurons of the rat cerebral cortex after oxygen and glucose deprivation.
Neuroscience 2002;111(1):47-56.
2001: Castrillo A; Pennington D J; Otto F; Parker P J; Owen M J; Boscá L
Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection.
The Journal of experimental medicine 2001;194(9):1231-42.
2001: Hortelano S; García-Martín M L; Cerdán S; Castrillo A; Alvarez A M; Boscá L
Intracellular water motion decreases in apoptotic macrophages after caspase activation.
Cell death and differentiation 2001;8(10):1022-8.
2001: Casado M; Callejas N A; Rodrigo J; Zhao X; Dey S K; Boscá L; Martín-Sanz P
Contribution of cyclooxygenase 2 to liver regeneration after partial hepatectomy.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(11):2016-8.
2001: Castrillo A; Mojena M; Hortelano S; Boscá L
Peroxisome proliferator-activated receptor-gamma-independent inhibition of macrophage activation by the non-thiazolidinedione agonist L-796,449. Comparison with the effects of 15-deoxy-delta(12,14)-prostaglandin J(2).
The Journal of biological chemistry 2001;276(36):34082-8.
2001: Hurtado O; Cárdenas A; Lizasoain I; Boscá L; Leza J C; Lorenzo P; Moro M A
Up-regulation of TNF-alpha convertase (TACE/ADAM17) after oxygen-glucose deprivation in rat forebrain slices.
Neuropharmacology 2001;40(8):1094-102.
2001: Callejas N A; Casado M; Díaz-Guerra M J; Boscá L; Martín-Sanz P
Expression of cyclooxygenase-2 promotes the release of matrix metalloproteinase-2 and -9 in fetal rat hepatocytes.
Hepatology (Baltimore, Md.) 2001;33(4):860-7.
2001: Madrigal J L; Moro M A; Lizasoain I; Lorenzo P; Castrillo A; Boscá L; Leza J C
Inducible nitric oxide synthase expression in brain cortex after acute restraint stress is regulated by nuclear factor kappaB-mediated mechanisms.
Journal of neurochemistry 2001;76(2):532-8.
2000: Hortelano S; Castrillo A; Alvarez A M; Boscá L
Contribution of cyclopentenone prostaglandins to the resolution of inflammation through the potentiation of apoptosis in activated macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6525-31.
2000: Callejas N A; Boscá L; Williams C S; DuBOIS R N; Martín-Sanz P
Regulation of cyclooxygenase 2 expression in hepatocytes by CCAAT/enhancer-binding proteins.
Gastroenterology 2000;119(2):493-501.
2000: Boscá L; Bodelón O G; Hortelano S; Casellas A; Bosch F
Anti-inflammatory action of type I interferons deduced from mice expressing interferon beta.
Gene therapy 2000;7(10):817-25.
2000: Cárdenas A; Moro M A; Hurtado O; Leza J C; Lorenzo P; Castrillo A; Bodelón O G; Boscá L; Lizasoain I
Implication of glutamate in the expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slices.
Journal of neurochemistry 2000;74(5):2041-8.
2000: Moro M A; De Alba J; Cárdenas A; De Cristóbal J; Leza J C; Lizasoain I; Díaz-Guerra M J; Boscá L; Lorenzo P
Mechanisms of the neuroprotective effect of aspirin after oxygen and glucose deprivation in rat forebrain slices.
Neuropharmacology 2000;39(7):1309-18.
2000: Castrillo A; Díaz-Guerra M J; Hortelano S; Martín-Sanz P; Boscá L
Inhibition of IkappaB kinase and IkappaB phosphorylation by 15-deoxy-Delta(12,14)-prostaglandin J(2) in activated murine macrophages.
Molecular and cellular biology 2000;20(5):1692-8.
2000: Castrillo A; Bodelón O G; Boscá L
Inhibitory effect of IGF-I on type 2 nitric oxide synthase expression in Ins-1 cells and protection against activation-dependent apoptosis: involvement of phosphatidylinositol 3-kinase.
Diabetes 2000;49(2):209-17.
2000: Olivenza R; Moro M A; Lizasoain I; Lorenzo P; Fernández A P; Rodrigo J; Boscá L; Leza J C
Chronic stress induces the expression of inducible nitric oxide synthase in rat brain cortex.
Journal of neurochemistry 2000;74(2):785-91.
1999: Hortelano S; Alvarez A M; Boscá L
Nitric oxide induces tyrosine nitration and release of cytochrome c preceding an increase of mitochondrial transmembrane potential in macrophages.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(15):2311-7.
1999: de las Heras B; Navarro A; Díaz-Guerra M J; Bermejo P; Castrillo A; Boscá L; Villar A
Inhibition of NOS-2 expression in macrophages through the inactivation of NF-kappaB by andalusol.
British journal of pharmacology 1999;128(3):605-12.
1999: Callejas N A; Casado M; Boscá L; Martín-Sanz P
Requirement of nuclear factor kappaB for the constitutive expression of nitric oxide synthase-2 and cyclooxygenase-2 in rat trophoblasts.
Journal of cell science 1999;112 Pt 18():3147-55.
1999: Martín-Sanz P; Boscá L; Olmedilla L; Perez-Peña J; Garutti I; Sanz J; Calleja J; Avellanal M; Ortega A; Aleixandre A; Barrigón S
Presence of a nitric oxide synthase inhibitor in the graft efflux during reperfusion in human liver transplantation.
Clinical transplantation 1999;13(3):221-30.
1999: Díaz-Guerra M J; Castrillo A; Martín-Sanz P; Boscá L
Negative regulation by protein tyrosine phosphatase of IFN-gamma-dependent expression of inducible nitric oxide synthase.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(11):6776-83.
1999: Díaz-Guerra M J; Castrillo A; Martín-Sanz P; Boscá L
Negative regulation by phosphatidylinositol 3-kinase of inducible nitric oxide synthase expression in macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):6184-90.
1999: Boscá L; Hortelano S
Mechanisms of nitric oxide-dependent apoptosis: involvement of mitochondrial mediators.
Cellular signalling 1999;11(4):239-44.
1999: Hortelano S; López-Collazo E; Boscá L
Protective effect of cyclosporin A and FK506 from nitric oxide-dependent apoptosis in activated macrophages.
British journal of pharmacology 1999;126(5):1139-46.
1999: Callejas N A; Castrillo A; Boscá L; Martín-Sanz P
Inhibition of prostaglandin synthesis up-regulates cyclooxygenase-2 induced by lipopolysaccharide and peroxisomal proliferators.
The Journal of pharmacology and experimental therapeutics 1999;288(3):1235-41.
1999: De Alba J; Cárdenas A; Moro M A; Leza J C; Lorenzo P; Boscá L; Lizasoain I
Down-regulation of neuronal nitric oxide synthase by nitric oxide after oxygen-glucose deprivation in rat forebrain slices.
Journal of neurochemistry 1999;72(1):248-54.
1998: Martín-Sanz P; Callejas N A; Casado M; Díaz-Guerra M J; Boscá L
Expression of cyclooxygenase-2 in foetal rat hepatocytes stimulated with lipopolysaccharide and pro-inflammatory cytokines.
British journal of pharmacology 1998;125(6):1313-9.
1998: López-Collazo E; Hortelano S; Boscá L
Interferon-alpha/beta inhibits the apoptosis induced by lipopolysaccharide and interferon-gamma in murine peritoneal macrophages.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1998;18(7):461-7.
1998: Llanos S; Caelles C; Azorín I; Renau-Piqueras J; Fernández-Luna J L; Boscá L; Muñoz A
The c-erbA alpha protooncogene induces apoptosis in glial cells via a protein kinase C- and bcl-2-suppressible mechanism.
Journal of neurochemistry 1998;70(6):2315-26.
1998: López-Collazo E; Hortelano S; Rojas A; Boscá L
Triggering of peritoneal macrophages with IFN-alpha/beta attenuates the expression of inducible nitric oxide synthase through a decrease in NF-kappaB activation.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(6):2889-95.
1998: Moro M A; De Alba J; Leza J C; Lorenzo P; Fernández A P; Bentura M L; Boscá L; Rodrigo J; Lizasoain I
Neuronal expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slices.
The European journal of neuroscience 1998;10(2):445-56.
1997: Casado M; Díaz-Guerra M J; Boscá L; Martín-Sanz P
Differential regulation of nitric oxide synthase mRNA expression by lipopolysaccharide and pro-inflammatory cytokines in fetal hepatocytes treated with cycloheximide.
The Biochemical journal 1997;327 ( Pt 3)():819-23.
1997: Díaz-Guerra M J; Velasco M; Martín-Sanz P; Boscá L
Nuclear factor kappaB is required for the transcriptional control of type II NO synthase in regenerating liver.
The Biochemical journal 1997;326 ( Pt 3)():791-7.
1997: Velasco M; Díaz-Guerra M J; Martín-Sanz P; Alvarez A; Boscá L
Rapid Up-regulation of IkappaBbeta and abrogation of NF-kappaB activity in peritoneal macrophages stimulated with lipopolysaccharide.
The Journal of biological chemistry 1997;272(37):23025-30.
1997: López-Collazo E; Mateo J; Miras-Portugal M T; Boscá L
Requirement of nitric oxide and calcium mobilization for the induction of apoptosis in adrenal vascular endothelial cells.
FEBS letters 1997;413(1):124-8.
1997: Díez-Fernández C; Sanz N; Boscá L; Hortelano S; Cascales M
Involvement of nitric oxide synthesis in hepatic perturbations induced in rats by a necrogenic dose of thioacetamide.
British journal of pharmacology 1997;121(4):820-6.
1997: Casado M; Velasco M; Boscá L; Martín-Sanz P
Absence of NO synthase type II expression in fetal liver from pregnant rats under septic shock conditions.
Hepatology (Baltimore, Md.) 1997;25(6):1406-11.
1997: Casado M; D-iaz-Guerra M J; Rodrigo J; Fernández A P; Boscá L; Martín-Sanz P
Expression of the calcium-independent cytokine-inducible (iNOS) isoform of nitric oxide synthase in rat placenta.
The Biochemical journal 1997;324 ( Pt 1)():201-7.
1997: Velasco M; Díaz-Guerra M J; Díaz-Achirica P; Andreu D; Rivas L; Boscá L
Macrophage triggering with cecropin A and melittin-derived peptides induces type II nitric oxide synthase expression.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(9):4437-43.
1997: Hortelano S; Boscá L
6-Mercaptopurine decreases the Bcl-2/Bax ratio and induces apoptosis in activated splenic B lymphocytes.
Molecular pharmacology 1997;51(3):414-21.
1997: Avila M A; Mingorance J; Martínez-Chantar M L; Casado M; Martin-Sanz P; Boscá L; Mato J M
Regulation of rat liver S-adenosylmethionine synthetase during septic shock: role of nitric oxide.
Hepatology (Baltimore, Md.) 1997;25(2):391-6.
1997: Hortelano S; Díaz-Guerra M J; Gonzalez-García A; Leonardo E; Gamallo C; Boscá L; Martínez-A C
Linomide administration to mice attenuates the induction of nitric oxide synthase elicited by lipopolysaccharide-activated macrophages and prevents nephritis in MRL/Mp-lpr/lpr mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1402-8.
1996: Díaz-Guerra M J; Bodelón O G; Velasco M; Whelan R; Parker P J; Boscá L
Up-regulation of protein kinase C-epsilon promotes the expression of cytokine-inducible nitric oxide synthase in RAW 264.7 cells.
The Journal of biological chemistry 1996;271(50):32028-33.
1996: Díaz-Guerra M J; Velasco M; Martín-Sanz P; Boscá L
Evidence for common mechanisms in the transcriptional control of type II nitric oxide synthase in isolated hepatocytes. Requirement of NF-kappaB activation after stimulation with bacterial cell wall products and phorbol esters.
The Journal of biological chemistry 1996;271(47):30114-20.
1996: Gil B; Casado M; Pajares M A; Boscá L; Mato J M; Martín-Sanz P; Alvarez L
Differential expression pattern of S-adenosylmethionine synthetase isoenzymes during rat liver development.
Hepatology (Baltimore, Md.) 1996;24(4):876-81.
1996: Martín-Sanz P; Díaz-Guerra M J; Casado M; Boscá L
Bacterial lipopolysaccharide antagonizes transforming growth factor beta 1-induced apoptosis in primary cultures of hepatocytes.
Hepatology (Baltimore, Md.) 1996;23(5):1200-7.
1996: Casado M; Boscá L; Martín-Sanz P
Multiple forms of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase are expressed in perinatal rat liver.
The American journal of physiology 1996;270(2 Pt 1):E244-50.
1995: Casado M; Boscá L; Martín-Sanz P
Differential regulation of the expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and pyruvate kinase by cyclic adenosine 3',5'-monophosphate in fetal and adult hepatocytes.
Journal of cellular physiology 1995;165(3):630-8.
1995: Terenzi F; Casado M; Martín-Sanz P; Boscá L
Epidermal growth factor inhibits cytokine-dependent nitric oxide synthase expression in hepatocytes.
FEBS letters 1995;368(1):193-6.
1995: Genaro A M; Hortelano S; Alvarez A; Martínez C; Boscá L
Splenic B lymphocyte programmed cell death is prevented by nitric oxide release through mechanisms involving sustained Bcl-2 levels.
The Journal of clinical investigation 1995;95(4):1884-90.
1995: Terenzi F; Díaz-Guerra M J; Casado M; Hortelano S; Leoni S; Boscá L
Bacterial lipopeptides induce nitric oxide synthase and promote apoptosis through nitric oxide-independent pathways in rat macrophages.
The Journal of biological chemistry 1995;270(11):6017-21.
1995: Hortelano S; Dewez B; Genaro A M; Díaz-Guerra M J; Boscá L
Nitric oxide is released in regenerating liver after partial hepatectomy.
Hepatology (Baltimore, Md.) 1995;21(3):776-86.
1994: Oset-Gasque M J; Parramón M; Hortelano S; Boscá L; González M P
Nitric oxide implication in the control of neurosecretion by chromaffin cells.
Journal of neurochemistry 1994;63(5):1693-700.
1994: Cascales M; Alvarez A; Gascó P; Fernández-Simón L; Sanz N; Boscá L
Cocaine-induced liver injury in mice elicits specific changes in DNA ploidy and induces programmed death of hepatocytes.
Hepatology (Baltimore, Md.) 1994;20(4 Pt 1):992-1001.
1994: Boscá L; Lazo P A
Induction of nitric oxide release by MRC OX-44 (anti-CD53) through a protein kinase C-dependent pathway in rat macrophages.
The Journal of experimental medicine 1994;179(4):1119-26.
1993: Díez-Fernández C; Boscá L; Fernández-Simón L; Alvarez A; Cascales M
Relationship between genomic DNA ploidy and parameters of liver damage during necrosis and regeneration induced by thioacetamide.
Hepatology (Baltimore, Md.) 1993;18(4):912-8.
1993: Casado M; Boscá L; Martín-Sanz P
Rat liver messenger ribonucleic acid and enzyme activity of 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase impairment during the late period of pregnancy.
Endocrinology 1993;133(3):1044-50.
1993: Genaro A M; Boscá L
Early signals in alloantigen induced B-cell proliferation. Comparison between B-cell triggering by intact allogeneic cells and solubilized alloantigen.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(4):1832-43.
1993: López-Alarcón L; Melián E; Muñoz-Alonso M J; Guijarro C; Boscá L; Felíu J E
Sulfonylureas activate glycogen phosphorylase and increase cytosolic free-Ca2+ levels in isolated rat hepatocytes.
Metabolism: clinical and experimental 1993;42(5):624-30.
1993: Baixeras E; Kroemer G; Cuende E; Márquez C; Boscá L; Alés Martínez J E; Martínez C
Signal transduction pathways involved in B-cell induction.
Immunological reviews 1993;132():5-47.
1993: Hortelano S; Genaro A M; Boscá L
Phorbol esters induce nitric oxide synthase and increase arginine influx in cultured peritoneal macrophages.
FEBS letters 1993;320(2):135-9.
1993: Boscá L; Morán F
Circular dichroism analysis of ligand-induced conformational changes in protein kinase C. Mechanism of translocation of the enzyme from the cytosol to the membranes and its implications.
The Biochemical journal 1993;290 ( Pt 3)():827-32.
1993: Junco M; Díaz-Guerra M J; Boscá L
Differential calcium mobilization by vasopressin, angiotensin II, gastrin-releasing peptide, and adenosine triphosphate in adult and fetal hepatocytes. Relevance for the activation of calcium-dependent enzymes.
Endocrinology 1993;132(1):309-18.
1992: Hortelano S; Genaro A M; Boscá L
Phorbol esters induce nitric oxide synthase activity in rat hepatocytes. Antagonism with the induction elicited by lipopolysaccharide.
The Journal of biological chemistry 1992;267(35):24937-40.
1992: Cascales M; Martin-Sanz P; Alvarez A; Sanchez-Pérez M; Diez Fernández C; Boscá L
Isoenzymes of carbohydrate metabolism in primary cultures of hepatocytes from thioacetamide-induced rat liver necrosis: responses to growth factors.
Hepatology (Baltimore, Md.) 1992;16(1):232-40.
1992: Martín-Sanz P; Cascales M; Boscá L
Characterization of 6-phosphofructo-2-kinase from foetal-rat liver.
The Biochemical journal 1992;281 ( Pt 2)():457-63.
1991: Díaz-Guerra M J; Junco M; Boscá L
Oleic acid promotes changes in the subcellular distribution of protein kinase C in isolated hepatocytes.
The Journal of biological chemistry 1991;266(35):23568-76.
1991: Boscá L; Márquez C; Martínez C
B cell triggering by bacterial lipopeptide involves both translocation and activation of the membrane-bound form of protein kinase C.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(5):1463-9.
1991: Márquez C; Martínez C; Boscá L
Protein kinase C mobilization in B lymphocytes. Differential isoenzyme translocation upon activation.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(2):627-32.
1990: Díaz-Guerra M J; Boscá L
Lack of translocation of protein kinase C from the cytosol to the membranes in vasopressin-stimulated hepatocytes.
The Biochemical journal 1990;269(1):163-8.
1990: Junco M; Díaz-Guerra M J; Boscá L
Substrate-dependent inhibition of protein kinase C by specific inhibitors.
FEBS letters 1990;263(1):169-71.
1989: Mojena M; Boscá L
Identification of an anti-A and anti-B blood group glycosyltransferase antibody after incompatible bone marrow transplant.
Blood 1989;74(3):1134-8.
1989: Boscá L; Díaz-Guerra M J; Mojena M
Oleate-induced translocation of protein kinase C to hepatic microsomal membranes.
Biochemical and biophysical research communications 1989;160(3):1243-9.
1989: Cascales C; Boscá L; Martín-Sanz P; Brindley D N; Cascales M
Translocation of phosphatidate phosphohydrolase from the cytosol to microsomal membranes in thioacetamide-induced liver tumours in rats.
Toxicology letters 1989;47(1):9-16.
1989: Martin-Sanz P; Cascales M; Boscá L
Glucagon-induced changes in fructose 2,6-bisphosphate and 6-phosphofructo-2-kinase in cultured rat foetal hepatocytes.
The Biochemical journal 1989;257(3):795-9.
1988: Barbolla L; Mojena M; Boscá L
Presence of antibody to A- and B-transferases in minor incompatible bone marrow transplant.
British journal of haematology 1988;70(4):471-6.
1988: Cascales C; Boscá L; Martin A; Brindley D N; Cascales M
Age-related changes in the translocation of phosphatidate phosphohydrolase from the cytosol to microsomal membranes in rat liver.
Biochimica et biophysica acta 1988;963(2):384-8.
1988: Boscá L; Díaz-Guerra M J
Activation of protein kinase C from B lymphocytes by lipid A.
Biochemical and biophysical research communications 1988;152(1):149-54.
1987: Martín-Sanz P; Cascales M; Boscá L
Fructose 2,6-bisphosphate in isolated foetal hepatocytes.
FEBS letters 1987;225(1-2):37-42.

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