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Alexander Tomasz

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Michael M Mwangi; Jennifer Tsai; Govindan Vijayadamodar; Michelle Benitez; Marilyn Chung; Lei Du; Thomas P Jarvie; Choonkeun Kim; Alexander Tomasz
Whole-Genome Sequencing Reveals a Link Between β-Lactam Resistance and Synthetases of the Alarmone (p)ppGpp in Staphylococcus aureus.
Alexander Tomasz
The use of whole genome sequencing to solve an epidemiological puzzle.
Choonkeun Kim; Catarina Milheiriço; Hermínia de Lencastre; Susana Gardete; Matt T G Holden; Mark A Holmes; Alexander Tomasz
Properties of a novel PBP2A protein homolog from Staphylococcus aureus strain LGA251 and its contribution to the β-lactam-resistant phenotype.

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2013: Michael M Mwangi; Jennifer Tsai; Govindan Vijayadamodar; Michelle Benitez; Marilyn Chung; Lei Du; Thomas P Jarvie; Choonkeun Kim; Alexander Tomasz
Whole-Genome Sequencing Reveals a Link Between β-Lactam Resistance and Synthetases of the Alarmone (p)ppGpp in Staphylococcus aureus.
Microbial drug resistance (Larchmont, N.Y.) 2013;19(3):153-9.
2013: Alexander Tomasz
The use of whole genome sequencing to solve an epidemiological puzzle.
EMBO molecular medicine 2013;5(4):486-7.
2012: Choonkeun Kim; Catarina Milheiriço; Hermínia de Lencastre; Susana Gardete; Matt T G Holden; Mark A Holmes; Alexander Tomasz
Properties of a novel PBP2A protein homolog from Staphylococcus aureus strain LGA251 and its contribution to the β-lactam-resistant phenotype.
The Journal of biological chemistry 2012;287(44):36854-63.
2012: Susana Gardete; Boris M Hartmann; Choonkeun Kim; Michael Mwangi; Christelle M Roux; Henry F Chambers; Paul Dunman; Alexander Tomasz
Genetic pathway in acquisition and loss of vancomycin resistance in a methicillin resistant Staphylococcus aureus (MRSA) strain of clonal type USA300.
PLoS pathogens 2012;8(2):e1002505.
2012: Teresa A Figueiredo; Ana Madalena Ludovice; Rita G Sobral; Waldemar Vollmer; João Manuel Feio de Almeida; Hermínia de Lencastre; Nhat K Bui; Alexander Tomasz
Identification of genetic determinants and enzymes involved with the amidation of glutamic acid residues in the peptidoglycan of Staphylococcus aureus.
PLoS pathogens 2012;8(1):e1002508.
2011: Herminia de Lencastre; Alexander Tomasz
The CEM-NET initiative: molecular biology and epidemiology in alliance--tracking antibiotic-resistant staphylococci and pneumococci in hospitals and in the community.
International journal of medical microbiology : IJMM 2011;301(8):623-9.
2009: Florian Gehre; Radek Spisek; Arun S Kharat; Phillip Matthews; Anjli Kukreja; Robert M Anthony; Madhav V Dhodapkar; Waldemar Vollmer; Alexander Tomasz
Role of teichoic acid choline moieties in the virulence of Streptococcus pneumoniae.
Infection and immunity 2009;77(7):2824-31.
2009: Sandro F F Pereira; Adriano O Henriques; Mariana G Pinho; Herminia de Lencastre; Alexander Tomasz
Evidence for a dual role of PBP1 in the cell division and cell separation of Staphylococcus aureus.
Molecular microbiology 2009;72(4):895-904.
2009: Aude Antignac; Alexander Tomasz
Reconstruction of the phenotypes of methicillin-resistant Staphylococcus aureus by replacement of the staphylococcal cassette chromosome mec with a plasmid-borne copy of Staphylococcus sciuri pbpD gene.
Antimicrobial agents and chemotherapy 2009;53(2):435-41.
2008: Arun S Kharat; Dalia Denapaite; Florian Gehre; Reinhold Brückner; Waldemar Vollmer; Regine Hakenbeck; Alexander Tomasz
Different pathways of choline metabolism in two choline-independent strains of Streptococcus pneumoniae and their impact on virulence.
Journal of bacteriology 2008;190(17):5907-14.
2008: Marilyn Chung; Aude Antignac; Choonkeun Kim; Alexander Tomasz
Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
Antimicrobial agents and chemotherapy 2008;52(8):2709-17.
2008: F Gehre; Stephen Leib; D Grandgirard; J Kummer; A Bühlmann; F Simon; R Gäumann; Arun S Kharat; M G Täuber; Alexander Tomasz
Essential role of choline for pneumococcal virulence in an experimental model of meningitis.
Journal of internal medicine 2008;264(2):143-54.
2008: Adrian Lloyd; Andrea M Gilbey; Anne Blewett; Gianfranco De Pascale; Ahmed El Zoeiby; Roger C Levesque; Anita C Catherwood; Alexander Tomasz; Timothy D H Bugg; David I Roper; Christopher G Dowson
Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan.
The Journal of biological chemistry 2008;283(10):6402-17.
2008: Krzysztof Sieradzki; Marilyn Chung; Alexander Tomasz
Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.
Antimicrobial agents and chemotherapy 2008;52(2):505-12.
2008: Yanjiao Zhou; Aude Antignac; Shang Wei Wu; Alexander Tomasz
Penicillin-binding proteins and cell wall composition in beta-lactam-sensitive and -resistant strains of Staphylococcus sciuri.
Journal of bacteriology 2008;190(2):508-14.
2007: Aude Antignac; Krzysztof Sieradzki; Alexander Tomasz
Perturbation of cell wall synthesis suppresses autolysis in Staphylococcus aureus: evidence for coregulation of cell wall synthetic and hydrolytic enzymes.
Journal of bacteriology 2007;189(21):7573-80.
2007: Hermínia de Lencastre; Duarte Oliveira; Alexander Tomasz
Antibiotic resistant Staphylococcus aureus: a paradigm of adaptive power.
Current opinion in microbiology 2007;10(5):428-35.
2007: Marlen Damjanovic; Arun S Kharat; Alice Eberhardt; Alexander Tomasz; Waldemar Vollmer
The essential tacF gene is responsible for the choline-dependent growth phenotype of Streptococcus pneumoniae.
Journal of bacteriology 2007;189(19):7105-11.
2007: Pedro M Pereira; Sergio Filipe; Alexander Tomasz; Mariana G Pinho
Fluorescence ratio imaging microscopy shows decreased access of vancomycin to cell wall synthetic sites in vancomycin-resistant Staphylococcus aureus.
Antimicrobial agents and chemotherapy 2007;51(10):3627-33.
2007: Michael M Mwangi; Shang Wei Wu; Yanjiao Zhou; Krzysztof Sieradzki; Hermínia de Lencastre; Paul Richardson; David Bruce; Edward Rubin; Eugene Myers; Eric D Siggia; Alexander Tomasz
Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(22):9451-6.
2007: S F F Pereira; Adriano O Henriques; Mariana G Pinho; Hermínia de Lencastre; Alexander Tomasz
Role of PBP1 in cell division of Staphylococcus aureus.
Journal of bacteriology 2007;189(9):3525-31.
2007: Rita G Sobral; Alison E Jones; Shelley G Des Etages; Thomas J Dougherty; Robert Peitzsch; Terry Gaasterland; Ana Madalena Ludovice; Hermínia de Lencastre; Alexander Tomasz
Extensive and genome-wide changes in the transcription profile of Staphylococcus aureus induced by modulating the transcription of the cell wall synthesis gene murF.
Journal of bacteriology 2007;189(6):2376-91.
2006: Susana Gardete; Shang Wei Wu; S Gill; Alexander Tomasz
Role of VraSR in antibiotic resistance and antibiotic-induced stress response in Staphylococcus aureus.
Antimicrobial agents and chemotherapy 2006;50(10):3424-34.
2006: M Inês Crisóstomo; Waldemar Vollmer; Arun S Kharat; Silja Inhülsen; Florian Gehre; Stephan Buckenmaier; Alexander Tomasz
Attenuation of penicillin resistance in a peptidoglycan O-acetyl transferase mutant of Streptococcus pneumoniae.
Molecular microbiology 2006;61(6):1497-509.
2006: Susana Gardete; Hermínia de Lencastre; Alexander Tomasz
A link in transcription between the native pbpB and the acquired mecA gene in a strain of Staphylococcus aureus.
Microbiology (Reading, England) 2006;152(Pt 9):2549-58.
2006: Arun S Kharat; Alexander Tomasz
Drastic reduction in the virulence of Streptococcus pneumoniae expressing type 2 capsular polysaccharide but lacking choline residues in the cell wall.
Molecular microbiology 2006;60(1):93-107.
2006: Rita G Sobral; Ana Madalena Ludovice; Hermínia de Lencastre; Alexander Tomasz
Role of murF in cell wall biosynthesis: isolation and characterization of a murF conditional mutant of Staphylococcus aureus.
Journal of bacteriology 2006;188(7):2543-53.
2006: Krzysztof Sieradzki; Alexander Tomasz
Inhibition of the autolytic system by vancomycin causes mimicry of vancomycin-intermediate Staphylococcus aureus-type resistance, cell concentration dependence of the MIC, and antibiotic tolerance in vancomycin-susceptible S. aureus.
Antimicrobial agents and chemotherapy 2006;50(2):527-33.
2006: Fionnuala McAleese; Shang Wei Wu; Krzysztof Sieradzki; Paul Dunman; Ellen Murphy; Steven Projan; Alexander Tomasz
Overexpression of genes of the cell wall stimulon in clinical isolates of Staphylococcus aureus exhibiting vancomycin-intermediate- S. aureus-type resistance to vancomycin.
Journal of bacteriology 2006;188(3):1120-33.
2006: Alexander Tomasz
Microbiology. Weapons of microbial drug resistance abound in soil flora.
Science (New York, N.Y.) 2006;311(5759):342-3.
2005: Anatoly Severin; Shang Wei Wu; Keiko Tabei; Alexander Tomasz
High-level (beta)-lactam resistance and cell wall synthesis catalyzed by the mecA homologue of Staphylococcus sciuri introduced into Staphylococcus aureus.
Journal of bacteriology 2005;187(19):6651-8.
2005: Tomasz A Łeski; Alexander Tomasz
Role of penicillin-binding protein 2 (PBP2) in the antibiotic susceptibility and cell wall cross-linking of Staphylococcus aureus: evidence for the cooperative functioning of PBP2, PBP4, and PBP2A.
Journal of bacteriology 2005;187(5):1815-24.
2005: Shang Wei Wu; Herminia de Lencastre; Alexander Tomasz
Expression of high-level methicillin resistance in Staphylococcus aureus from the Staphylococcus sciuri mec A homologue: role of mutation(s) in the genetic background and in the coding region of mec A.
Microbial drug resistance (Larchmont, N.Y.) 2005;11(3):215-24.
2005: Helena Zemlicková; M Inês Crisóstomo; Maria Cristina C Brandileone; Teresa Camou; Elizabeth Castañeda; Alejandra Corso; Gabriela Echániz-Aviles; Mónika Pásztor; Alexander Tomasz
Serotypes and clonal types of penicillin-susceptible streptococcus pneumoniae causing invasive disease in children in five Latin American countries.
Microbial drug resistance (Larchmont, N.Y.) 2005;11(3):195-204.
2004: Anatoly Severin; Shang Wei Wu; Keiko Tabei; Alexander Tomasz
Penicillin-binding protein 2 is essential for expression of high-level vancomycin resistance and cell wall synthesis in vancomycin-resistant Staphylococcus aureus carrying the enterococcal vanA gene complex.
Antimicrobial agents and chemotherapy 2004;48(12):4566-73.
2004: Susana Gardete; Ana Madalena Ludovice; Rita G Sobral; Sergio Filipe; Hermínia de Lencastre; Alexander Tomasz
Role of murE in the Expression of beta-lactam antibiotic resistance in Staphylococcus aureus.
Journal of bacteriology 2004;186(6):1705-13.
2004: Marilyn Chung; Gordon M Dickinson; Hermínia de Lencastre; Alexander Tomasz
International clones of methicillin-resistant Staphylococcus aureus in two hospitals in Miami, Florida.
Journal of clinical microbiology 2004;42(2):542-7.
2004: Anatoly Severin; Keiko Tabei; Fred C Tenover; Marilyn Chung; Nancy Clarke; Alexander Tomasz
High level oxacillin and vancomycin resistance and altered cell wall composition in Staphylococcus aureus carrying the staphylococcal mecA and the enterococcal vanA gene complex.
The Journal of biological chemistry 2004;279(5):3398-407.
2004: Anatoly Severin; Keiko Tabei; Alexander Tomasz
The structure of the cell wall peptidoglycan of Bacillus cereus RSVF1, a strain closely related to Bacillus anthracis.
Microbial drug resistance (Larchmont, N.Y.) 2004;10(2):77-82.
2003: Krzysztof Sieradzki; Alexander Tomasz
Alterations of cell wall structure and metabolism accompany reduced susceptibility to vancomycin in an isogenic series of clinical isolates of Staphylococcus aureus.
Journal of bacteriology 2003;185(24):7103-10.
2003: Sara Silva; Rodrigo Gouveia-Oliveira; António Maretzek; Joao Carrico; Thorolfur Gudnason; Karl G Kristinsson; Karl Ekdahl; António Brito-Avô; Alexander Tomasz; I Santos Sanches; Hermínia de Lencastre; Jonas Almeida
EURISWEB--Web-based epidemiological surveillance of antibiotic-resistant pneumococci in day care centers.
BMC medical informatics and decision making 2003;3():9.
2003: Arun S Kharat; Alexander Tomasz
Inactivation of the srtA gene affects localization of surface proteins and decreases adhesion of Streptococcus pneumoniae to human pharyngeal cells in vitro.
Infection and immunity 2003;71(5):2758-65.
2003: Krzysztof Sieradzki; T Leski; James D Dick; L Borio; Alexander Tomasz
Evolution of a vancomycin-intermediate Staphylococcus aureus strain in vivo: multiple changes in the antibiotic resistance phenotypes of a single lineage of methicillin-resistant S. aureus under the impact of antibiotics administered for chemotherapy.
Journal of clinical microbiology 2003;41(4):1687-93.
2003: Alexander Tomasz
"Intelligence coup" for drug designers: crystal structure of Staphylococcus aureus beta-lactam resistance protein PBP2A.
Lancet 2003;361(9360):795-6.
2003: Rita G Sobral; Ana Madalena Ludovice; Susana Gardete; K Tabei; Hermínia de Lencastre; Alexander Tomasz
Normally functioning murF is essential for the optimal expression of methicillin resistance in Staphylococcus aureus.
Microbial drug resistance (Larchmont, N.Y.) 2003;9(3):231-41.
2003: Marta Aires de Sousa; M Inês Crisóstomo; I Santos Sanches; J S Wu; J Fuzhong; Alexander Tomasz; Hermínia de Lencastre
Frequent recovery of a single clonal type of multidrug-resistant Staphylococcus aureus from patients in two hospitals in Taiwan and China.
Journal of clinical microbiology 2003;41(1):159-63.
2003: Isabel Couto; Shang Wei Wu; Alexander Tomasz; Hermínia de Lencastre
Development of methicillin resistance in clinical isolates of Staphylococcus sciuri by transcriptional activation of the mecA homologue native to s.
Journal of bacteriology 2003;185(2):645-53.
2003: Soumya S Ray; Jeffrey B Bonanno; Hua Chen; Hermínia de Lencastre; Shangwei Wu; Alexander Tomasz; Stephen K Burley
X-ray structure of an M. jannaschii DNA-binding protein: implications for antibiotic resistance in S. aureus.
Proteins 2003;50(1):170-3.
2002: Hermínia de Lencastre; Alexander Tomasz
From ecological reservoir to disease: the nasopharynx, day-care centres and drug-resistant clones of Streptococcus pneumoniae.
The Journal of antimicrobial chemotherapy 2002;50 Suppl S2():75-81.
2002: Waldemar Vollmer; Alexander Tomasz
Peptidoglycan N-acetylglucosamine deacetylase, a putative virulence factor in Streptococcus pneumoniae.
Infection and immunity 2002;70(12):7176-8.
2002: Soumya S Ray; Jeffrey B Bonanno; Kanagalaghatta R Rajashankar; Mariana G Pinho; Guoshun He; Hermínia de Lencastre; Alexander Tomasz; Stephen K Burley
Cocrystal structures of diaminopimelate decarboxylase: mechanism, evolution, and inhibition of an antibiotic resistance accessory factor.
Structure (London, England : 1993) 2002;10(11):1499-508.
2002: Raquel Sá-Leão; Alexander Tomasz; Ilda Santos-Sanches; Hermínia de Lencastre
Pilot study of the genetic diversity of the pneumococcal nasopharyngeal flora among children attending day care centers.
Journal of clinical microbiology 2002;40(10):3577-85.
2002: Raquel Sá-Leão; Sigurdur E Vilhelmsson; Hermínia de Lencastre; Karl G Kristinsson; Alexander Tomasz
Diversity of penicillin-nonsusceptible Streptococcus pneumoniae circulating in Iceland after the introduction of penicillin-resistant clone Spain(6B)-2.
The Journal of infectious diseases 2002;186(7):966-75.
2002: Duarte C Oliveira; Alexander Tomasz; Hermínia de Lencastre
Secrets of success of a human pathogen: molecular evolution of pandemic clones of meticillin-resistant Staphylococcus aureus.
The Lancet infectious diseases 2002;2(3):180-9.
2002: Sergio Filipe; Elena Severina; Alexander Tomasz
The murMN operon: a functional link between antibiotic resistance and antibiotic tolerance in Streptococcuspneumoniae.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1550-5.
2001: Mariana G Pinho; Sergio Filipe; Hermínia de Lencastre; Alexander Tomasz
Complementation of the essential peptidoglycan transpeptidase function of penicillin-binding protein 2 (PBP2) by the drug resistance protein PBP2A in Staphylococcus aureus.
Journal of bacteriology 2001;183(22):6525-31.
2001: Raquel Sá-Leão; Alexander Tomasz; Hermínia de Lencastre
Multilocus sequence typing of Streptococcus pneumoniae clones with unusual drug resistance patterns: genetic backgrounds and relatedness to other epidemic clones.
The Journal of infectious diseases 2001;184(9):1206-10.
2001: Sergio Filipe; Elena Severina; Alexander Tomasz
Functional analysis of Streptococcus pneumoniae MurM reveals the region responsible for its specificity in the synthesis of branched cell wall peptides.
The Journal of biological chemistry 2001;276(43):39618-28.
2001: Mariana G Pinho; Hermínia de Lencastre; Alexander Tomasz
An acquired and a native penicillin-binding protein cooperate in building the cell wall of drug-resistant staphylococci.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(19):10886-91.
2001: M Inês Crisóstomo; Henrik Westh; Alexander Tomasz; M Chung; Duarte C Oliveira; Hermínia de Lencastre
The evolution of methicillin resistance in Staphylococcus aureus: similarity of genetic backgrounds in historically early methicillin-susceptible and -resistant isolates and contemporary epidemic clones.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(17):9865-70.
2001: Shang Wei Wu; Hermínia de Lencastre; Alexander Tomasz
Recruitment of the mecA gene homologue of Staphylococcus sciuri into a resistance determinant and expression of the resistant phenotype in Staphylococcus aureus.
Journal of bacteriology 2001;183(8):2417-24.
2001: Waldemar Vollmer; Alexander Tomasz
Identification of the teichoic acid phosphorylcholine esterase in Streptococcus pneumoniae.
Molecular microbiology 2001;39(6):1610-22.
2001: Duarte C Oliveira; Alexander Tomasz; Hermínia de Lencastre
The evolution of pandemic clones of methicillin-resistant Staphylococcus aureus: identification of two ancestral genetic backgrounds and the associated mec elements.
Microbial drug resistance (Larchmont, N.Y.) 2001;7(4):349-61.
2001: Sergio Filipe; Elena Severina; Alexander Tomasz
The role of murMN operon in penicillin resistance and antibiotic tolerance of Streptococcus pneumoniae.
Microbial drug resistance (Larchmont, N.Y.) 2001;7(4):303-16.
2001: RB Roberts; Alexander Tomasz; Alejandra Corso; J Hargrave; Elena Severina
Penicillin-resistant Streptococcus pneumoniae in metropolitan New York hospitals: case control study and molecular typing of resistant isolates.
Microbial drug resistance (Larchmont, N.Y.) 2001;7(2):137-52.
2000: Sergio Filipe; Elena Severina; Alexander Tomasz
Distribution of the mosaic structured murM genes among natural populations of Streptococcus pneumoniae.
Journal of bacteriology 2000;182(23):6798-805.
2000: Raquel Sá-Leão; Alexander Tomasz; I Santos Sanches; Sónia Nunes; CR Alves; A B Avô; Joana Saldanha; Karl G Kristinsson; Hermínia de Lencastre
Genetic diversity and clonal patterns among antibiotic-susceptible and -resistant Streptococcus pneumoniae colonizing children: day care centers as autonomous epidemiological units.
Journal of clinical microbiology 2000;38(11):4137-44.
2000: Raquel Sá-Leão; Alexander Tomasz; I Santos Sanches; António Brito-Avô; Sigurdur E Vilhelmsson; Karl G Kristinsson; Hermínia de Lencastre
Carriage of internationally spread clones of Streptococcus pneumoniae with unusual drug resistance patterns in children attending day care centers in Lisbon, Portugal.
The Journal of infectious diseases 2000;182(4):1153-60.
2000: Sergio Filipe; Mariana G Pinho; Alexander Tomasz
Characterization of the murMN operon involved in the synthesis of branched peptidoglycan peptides in Streptococcus pneumoniae.
The Journal of biological chemistry 2000;275(36):27768-74.
2000: Waldemar Vollmer; Alexander Tomasz
The pgdA gene encodes for a peptidoglycan N-acetylglucosamine deacetylase in Streptococcus pneumoniae.
The Journal of biological chemistry 2000;275(27):20496-501.
2000: Sergio Filipe; Alexander Tomasz
Inhibition of the expression of penicillin resistance in Streptococcus pneumoniae by inactivation of cell wall muropeptide branching genes.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4891-6.
2000: I G Boneca; Z H Huang; Douglas A Gage; Alexander Tomasz
Characterization of Staphylococcus aureus cell wall glycan strands, evidence for a new beta-N-acetylglucosaminidase activity.
The Journal of biological chemistry 2000;275(14):9910-8.
2000: Sigurdur E Vilhelmsson; Alexander Tomasz; Karl G Kristinsson
Molecular evolution in a multidrug-resistant lineage of Streptococcus pneumoniae: emergence of strains belonging to the serotype 6B Icelandic clone that lost antibiotic resistance traits.
Journal of clinical microbiology 2000;38(4):1375-81.
2000: Mariana G Pinho; Hermínia de Lencastre; Alexander Tomasz
Cloning, characterization, and inactivation of the gene pbpC, encoding penicillin-binding protein 3 of Staphylococcus aureus.
Journal of bacteriology 2000;182(4):1074-9.
2000: Marta Aires de Sousa; Hermínia de Lencastre; Ilda Santos-Sanches; K Kikuchi; K Totsuka; Alexander Tomasz
Similarity of antibiotic resistance patterns and molecular typing properties of methicillin-resistant Staphylococcus aureus isolates widely spread in hospitals in New York City and in a hospital in Tokyo, Japan.
Microbial drug resistance (Larchmont, N.Y.) 2000;6(3):253-8.
2000: RB Roberts; Marilyn Chung; Hermínia de Lencastre; J Hargrave; Alexander Tomasz; D P Nicolau; J F John; O Korzeniowski
Distribution of methicillin-resistant Staphylococcus aureus clones among health care facilities in Connecticut, New Jersey, and Pennsylvania. .
Microbial drug resistance (Larchmont, N.Y.) 2000;6(3):245-51.
2000: Ilda Santos-Sanches; Rosario Mato; Hermínia de Lencastre; Alexander Tomasz
Patterns of multidrug resistance among methicillin-resistant hospital isolates of coagulase-positive and coagulase-negative staphylococci collected in the international multicenter study RESIST in 1997 and 1998.
Microbial drug resistance (Larchmont, N.Y.) 2000;6(3):199-211.
2000: Marilyn Chung; Hermínia de Lencastre; P Matthews; Alexander Tomasz; I Adamsson; Marta Aires de Sousa; Teresa Camou; C Cocuzza; Alejandra Corso; Isabel Couto; A Dominguez; M Gniadkowski; Richard Goering; A Gomes; K Kikuchi; A Marchese; Rosario Mato; Oto Melter; Duarte Oliveira; R Palacio; Raquel Sá-Leão; Ilda Santos-Sanches; J H Song; Panayotis Tassios; P Villari
Molecular typing of methicillin-resistant Staphylococcus aureus by pulsed-field gel electrophoresis: comparison of results obtained in a multilaboratory effort using identical protocols and MRSA strains.
Microbial drug resistance (Larchmont, N.Y.) 2000;6(3):189-98.
1999: Krzysztof Sieradzki; Alexander Tomasz
Gradual alterations in cell wall structure and metabolism in vancomycin-resistant mutants of Staphylococcus aureus.
Journal of bacteriology 1999;181(24):7566-70.
1999: Elena Severina; Mario ramirez; Alexander Tomasz
Prophage carriage as a molecular epidemiological marker in Streptococcus pneumoniae.
Journal of clinical microbiology 1999;37(10):3308-15.
1999: Alexander Tomasz
New faces of an old pathogen: emergence and spread of multidrug-resistant Streptococcus pneumoniae.
The American journal of medicine 1999;107(1A):55S-62S.
1999: Krzysztof Sieradzki; Mariana G Pinho; Alexander Tomasz
Inactivated pbp4 in highly glycopeptide-resistant laboratory mutants of Staphylococcus aureus.
The Journal of biological chemistry 1999;274(27):18942-6.
1999: Mario ramirez; Elena Severina; Alexander Tomasz
A high incidence of prophage carriage among natural isolates of Streptococcus pneumoniae.
Journal of bacteriology 1999;181(12):3618-25.
1999: L Setchanova; Alexander Tomasz
Molecular characterization of penicillin-resistant Streptococcus pneumoniae isolates from Bulgaria.
Journal of clinical microbiology 1999;37(3):638-48.
1999: Krzysztof Sieradzki; RB Roberts; S W Haber; Alexander Tomasz
The development of vancomycin resistance in a patient with methicillin-resistant Staphylococcus aureus infection.
The New England journal of medicine 1999;340(7):517-23.
1999: Krzysztof Sieradzki; Shang Wei Wu; Alexander Tomasz
Inactivation of the methicillin resistance gene mecA in vancomycin-resistant Staphylococcus aureus.
Microbial drug resistance (Larchmont, N.Y.) 1999;5(4):253-7.
1999: Mario ramirez; Alexander Tomasz
Acquisition of new capsular genes among clinical isolates of antibiotic-resistant Streptococcus pneumoniae.
Microbial drug resistance (Larchmont, N.Y.) 1999;5(4):241-6.
1999: Hermínia de Lencastre; Shang Wei Wu; Mariana G Pinho; Ana Madalena Ludovice; Sergio Filipe; Susana Gardete; Rita G Sobral; S Gill; Marilyn Chung; Alexander Tomasz
Antibiotic resistance as a stress response: complete sequencing of a large number of chromosomal loci in Staphylococcus aureus strain COL that impact on the expression of resistance to methicillin.
Microbial drug resistance (Larchmont, N.Y.) 1999;5(3):163-75.
1999: Hermínia de Lencastre; Arthur E Brown; Marilyn Chung; D Armstrong; Alexander Tomasz
Role of transposon Tn5482 in the epidemiology of vancomycin-resistant Enterococcus faecium in the pediatric oncology unit of a New York City Hospital.
Microbial drug resistance (Larchmont, N.Y.) 1999;5(2):113-29.
1999: Hermínia de Lencastre; Karl G Kristinsson; António Brito-Avô; I Santos Sanches; Raquel Sá-Leão; Joana Saldanha; E Sigvaldadottir; S Karlsson; Duarte Oliveira; Rosario Mato; Marta Aires de Sousa; Alexander Tomasz
Carriage of respiratory tract pathogens and molecular epidemiology of Streptococcus pneumoniae colonization in healthy children attending day care centers in Lisbon, Portugal.
Microbial drug resistance (Larchmont, N.Y.) 1999;5(1):19-29.
1999: Shang Wei Wu; Hermínia de Lencastre; Alexander Tomasz
The Staphylococcus aureus transposon Tn551: complete nucleotide sequence and transcriptional analysis of the expression of the erythromycin resistance gene.
Microbial drug resistance (Larchmont, N.Y.) 1999;5(1):1-7.
1999: Krzysztof Sieradzki; RB Roberts; D Serur; J Hargrave; Alexander Tomasz
Heterogeneously vancomycin-resistant Staphylococcus epidermidis strain causing recurrent peritonitis in a dialysis patient during vancomycin therapy.
Journal of clinical microbiology 1999;37(1):39-44.
1998: Mariana G Pinho; Hermínia de Lencastre; Alexander Tomasz
Transcriptional analysis of the Staphylococcus aureus penicillin binding protein 2 gene.
Journal of bacteriology 1998;180(23):6077-81.
1998: Mario ramirez; Alexander Tomasz
Molecular characterization of the complete 23F capsular polysaccharide locus of Streptococcus pneumoniae.
Journal of bacteriology 1998;180(19):5273-8.
1998: A Marchese; Mario ramirez; G C Schito; Alexander Tomasz
Molecular epidemiology of penicillin-resistant Streptococcus pneumoniae isolates recovered in Italy from 1993 to 1996.
Journal of clinical microbiology 1998;36(10):2944-9.
1998: RB Roberts; A de Lencastre; William Eisner; Elena Severina; Bo Shopsin; Barry N Kreiswirth; Alexander Tomasz
Molecular epidemiology of methicillin-resistant Staphylococcus aureus in 12 New York hospitals. MRSA Collaborative Study Group.
The Journal of infectious diseases 1998;178(1):164-71.
1998: DL Horn; John B Zabriskie; R Austrian; P Patrick Cleary; J J Ferretti; Vincent Fischetti; Emil C Gotschlich; Edward L Kaplan; M McCarty; S M Opal; RB Roberts; Alexander Tomasz; Y Wachtfogel
Why have group A streptococci remained susceptible to penicillin? Report on a symposium.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1998;26(6):1341-5.
1998: Krzysztof Sieradzki; RB Roberts; D Serur; J Hargrave; Alexander Tomasz
Recurrent peritonitis in a patient on dialysis and prophylactic vancomycin.
Lancet 1998;351(9106):880-1.
1998: Elena Severina; Anatoly Severin; Alexander Tomasz
Antibacterial efficacy of nisin against multidrug-resistant Gram-positive pathogens.
The Journal of antimicrobial chemotherapy 1998;41(3):341-7.
1998: M Nesin; Mario ramirez; Alexander Tomasz
Capsular transformation of a multidrug-resistant Streptococcus pneumoniae in vivo.
The Journal of infectious diseases 1998;177(3):707-13.
1998: Krzysztof Sieradzki; P Villari; Alexander Tomasz
Low-level teicoplanin resistance and heteroresistance to vancomycin.
Annals of internal medicine 1998;128(3):245.
1998: Alejandra Corso; Elena Severina; V F Petruk; Y R Mauriz; Alexander Tomasz
Molecular characterization of penicillin-resistant Streptococcus pneumoniae isolates causing respiratory disease in the United States.
Microbial drug resistance (Larchmont, N.Y.) 1998;4(4):325-37.
1998: Gabriela Echániz-Aviles; ME Velázquez-Meza; M N Carnalla-Barajas; Araceli Soto-Noguerón; José Luis Di Fabio; Fortino Solórzano-Santos; Y Jiménez-Tapia; Alexander Tomasz
Predominance of the multiresistant 23F international clone of Streptococcus pneumoniae among isolates from Mexico.
Microbial drug resistance (Larchmont, N.Y.) 1998;4(3):241-6.
1998: Teresa Camou; María Hortal; Alexander Tomasz
The apparent importation of penicillin-resistant capsular type 14 Spanish/French clone of Streptococcus pneumoniae into Uruguay in the early 1990s.
Microbial drug resistance (Larchmont, N.Y.) 1998;4(3):219-24.
1998: Alexander Tomasz; Alejandra Corso; Elena Severina; Gabriela Echániz-Aviles; Maria Cristina C Brandileone; Teresa Camou; Elizabeth Castañeda; O Figueroa; A Rossi; José Luis Di Fabio
Molecular epidemiologic characterization of penicillin-resistant Streptococcus pneumoniae invasive pediatric isolates recovered in six Latin-American countries: an overview. PAHO/Rockefeller University Workshop. Pan American Health Organization.
Microbial drug resistance (Larchmont, N.Y.) 1998;4(3):195-207.
1998: Krzysztof Sieradzki; Alexander Tomasz
Suppression of glycopeptide resistance in a highly teicoplanin-resistant mutant of Staphylococcus aureus by transposon inactivation of genes involved in cell wall synthesis.
Microbial drug resistance (Larchmont, N.Y.) 1998;4(3):159-68.
1998: Krzysztof Sieradzki; P Villari; Alexander Tomasz
Decreased susceptibilities to teicoplanin and vancomycin among coagulase-negative methicillin-resistant clinical isolates of staphylococci.
Antimicrobial agents and chemotherapy 1998;42(1):100-7.
1998: S Wu; Hermínia de Lencastre; Alexander Tomasz
Genetic organization of the mecA region in methicillin-susceptible and methicillin-resistant strains of Staphylococcus sciuri.
Journal of bacteriology 1998;180(2):236-42.
1997: I G Boneca; Naxing Xu; Douglas A Gage; Boudewijn L M De Jonge; Alexander Tomasz
Structural characterization of an abnormally cross-linked muropeptide dimer that is accumulated in the peptidoglycan of methicillin- and cefotaxime-resistant mutants of Staphylococcus aureus.
The Journal of biological chemistry 1997;272(46):29053-9.
1997: A Tarasi; L L Dever; Alexander Tomasz
Activity of quinupristin/dalfopristin against Streptococcus pneumoniae in vitro and in vivo in the rabbit model of experimental meningitis.
The Journal of antimicrobial chemotherapy 1997;39 Suppl A():121-7.
1997: Krzysztof Sieradzki; Alexander Tomasz
Suppression of beta-lactam antibiotic resistance in a methicillin-resistant Staphylococcus aureus through synergic action of early cell wall inhibitors and some other antibiotics.
The Journal of antimicrobial chemotherapy 1997;39 Suppl A():47-51.
1997: Wesley E Kloos; DN Ballard; JA Webster; R J Hubner; Alexander Tomasz; Isabel Couto; Gary L Sloan; H P Dehart; F Fiedler; K Schubert; Hermínia de Lencastre; I Santos Sanches; Harry E Heath; Paul A LeBlanc; A Ljungh
Ribotype delineation and description of Staphylococcus sciuri subspecies and their potential as reservoirs of methicillin resistance and staphylolytic enzyme genes.
International journal of systematic bacteriology 1997;47(2):313-23.
1997: Krzysztof Sieradzki; Alexander Tomasz
Inhibition of cell wall turnover and autolysis by vancomycin in a highly vancomycin-resistant mutant of Staphylococcus aureus.
Journal of bacteriology 1997;179(8):2557-66.
1997: Anatoly Severin; Elena Severina; Alexander Tomasz
Abnormal physiological properties and altered cell wall composition in Streptococcus pneumoniae grown in the presence of clavulanic acid.
Antimicrobial agents and chemotherapy 1997;41(3):504-10.
1997: Anatoly Severin; D Horne; Alexander Tomasz
Autolysis and cell wall degradation in a choline-independent strain of Streptococcus pneumoniae.
Microbial drug resistance (Larchmont, N.Y.) 1997;3(4):391-400.
1997: A Tarasi; Y Chong; K Lee; Alexander Tomasz
Spread of the serotype 23F multidrug-resistant Streptococcus pneumoniae clone to South Korea.
Microbial drug resistance (Larchmont, N.Y.) 1997;3(1):105-9.
1997: Mario ramirez; Donald A Morrison; Alexander Tomasz
Ubiquitous distribution of the competence related genes comA and comC among isolates of Streptococcus pneumoniae.
Microbial drug resistance (Larchmont, N.Y.) 1997;3(1):39-52.
1997: Alexander Tomasz
Antibiotic resistance in Streptococcus pneumoniae.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1997;24 Suppl 1():S85-8.
1996: S Wu; Hermínia de Lencastre; Alexander Tomasz
Sigma-B, a putative operon encoding alternate sigma factor of Staphylococcus aureus RNA polymerase: molecular cloning and DNA sequencing.
Journal of bacteriology 1996;178(20):6036-42.
1996: Hermínia de Lencastre; A de Lencastre; Alexander Tomasz
Methicillin-resistant Staphylococcus aureus isolates recovered from a New York City hospital: analysis by molecular fingerprinting techniques.
Journal of clinical microbiology 1996;34(9):2121-4.
1996: Krzysztof Sieradzki; Alexander Tomasz
A highly vancomycin-resistant laboratory mutant of Staphylococcus aureus.
FEMS microbiology letters 1996;142(2-3):161-6.
1996: Anatoly Severin; A M Figueiredo; Alexander Tomasz
Separation of abnormal cell wall composition from penicillin resistance through genetic transformation of Streptococcus pneumoniae.
Journal of bacteriology 1996;178(7):1788-92.
1996: S Wu; C Piscitelli; Hermínia de Lencastre; Alexander Tomasz
Tracking the evolutionary origin of the methicillin resistance gene: cloning and sequencing of a homologue of mecA from a methicillin susceptible strain of Staphylococcus sciuri.
Microbial drug resistance (Larchmont, N.Y.) 1996;2(4):435-41.
1996: I Couto; Hermínia de Lencastre; Elena Severina; Wesley E Kloos; J A Webster; R J Hubner; I Santos Sanches; Alexander Tomasz
Ubiquitous presence of a mecA homologue in natural isolates of Staphylococcus sciuri.
Microbial drug resistance (Larchmont, N.Y.) 1996;2(4):377-91.
1996: Hermínia de Lencastre; Elena Severina; RB Roberts; Barry N Kreiswirth; Alexander Tomasz
Testing the efficacy of a molecular surveillance network: methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF) genotypes in six hospitals in the metropolitan New York City area. The BARG Initiative Pilot Study Group. Bacterial Antibiotic Resistance Group.
Microbial drug resistance (Larchmont, N.Y.) 1996;2(3):343-51.
1996: Rosario Mato; Hermínia de Lencastre; RB Roberts; Alexander Tomasz
Multiplicity of genetic backgrounds among vancomycin-resistant Enterococcus faecium isolates recovered from an outbreak in a New York City hospital.
Microbial drug resistance (Larchmont, N.Y.) 1996;2(3):309-17.
1996: S Wu; Hermínia de Lencastre; Andrej Sali; Alexander Tomasz
A phosphoglucomutase-like gene essential for the optimal expression of methicillin resistance in Staphylococcus aureus: molecular cloning and DNA sequencing.
Microbial drug resistance (Larchmont, N.Y.) 1996;2(2):277-86.
1996: Anatoly Severin; Alexander Tomasz
Naturally occurring peptidoglycan variants of Streptococcus pneumoniae.
Journal of bacteriology 1996;178(1):168-74.
1995: Anatoly Severin; M V Vaz Pato; A M Sá Figueiredo; Alexander Tomasz
Drastic changes in the peptidoglycan composition of penicillin resistant laboratory mutants of Streptococcus pneumoniae.
FEMS microbiology letters 1995;130(1):31-5.
1995: Anatoly Severin; Alexander Tomasz
Selective lysis of cultures and cell walls of penicillin-resistant but not penicillin-susceptible Streptococcus pneumoniae strains by a murein hydrolase complex.
Journal of bacteriology 1995;177(11):3316-9.
1995: I Santos Sanches; Mario ramirez; H Troni; Michael M Abecassis; M Padua; Alexander Tomasz; Hermínia de Lencastre
Evidence for the geographic spread of a methicillin-resistant Staphylococcus aureus clone between Portugal and Spain.
Journal of clinical microbiology 1995;33(5):1243-6.
1995: T Oshida; Motoyuki Sugai; Hitoshi Komatsuzawa; Y M Hong; Hidekazu Suginaka; Alexander Tomasz
A Staphylococcus aureus autolysin that has an N-acetylmuramoyl-L-alanine amidase domain and an endo-beta-N-acetylglucosaminidase domain: cloning, sequence analysis, and characterization.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(1):285-9.
1995: A Tarasi; N Sterk-Kuzmanovic; Krzysztof Sieradzki; S Schoenwald; R Austrian; Alexander Tomasz
Penicillin-resistant and multidrug-resistant Streptococcus pneumoniae in a pediatric hospital in Zagreb, Croatia.
Microbial drug resistance (Larchmont, N.Y.) 1995;1(2):169-76.
1995: Alexander Tomasz; R Munoz
Beta-Lactam antibiotic resistance in gram-positive bacterial pathogens of the upper respiratory tract: a brief overview of mechanisms.
Microbial drug resistance (Larchmont, N.Y.) 1995;1(2):103-9.
1995: A M Figueiredo; R Austrian; P Urbaskova; L A Teixeira; Alexander Tomasz
Novel penicillin-resistant clones of Streptococcus pneumoniae in the Czech Republic and in Slovakia.
Microbial drug resistance (Larchmont, N.Y.) 1995;1(1):71-8.
1994: A Ornelas-Soares; Hermínia de Lencastre; Boudewijn L M De Jonge; Alexander Tomasz
Reduced methicillin resistance in a new Staphylococcus aureus transposon mutant that incorporates muramyl dipeptides into the cell wall peptidoglycan.
The Journal of biological chemistry 1994;269(44):27246-50.
1994: Hermínia de Lencastre; Alexander Tomasz
Reassessment of the number of auxiliary genes essential for expression of high-level methicillin resistance in Staphylococcus aureus.
Antimicrobial agents and chemotherapy 1994;38(11):2590-8.
1994: Alexander Tomasz
Benefit and risk in the beta-lactam antibiotic-resistance strategies of Streptococcus pneumoniae and Staphylococcus aureus.
Trends in microbiology 1994;2(10):380-5.
1994: M A Dominguez; Hermínia de Lencastre; J Linares; Alexander Tomasz
Spread and maintenance of a dominant methicillin-resistant Staphylococcus aureus (MRSA) clone during an outbreak of MRSA disease in a Spanish hospital.
Journal of clinical microbiology 1994;32(9):2081-7.
1994: Alexander Tomasz
Multiple-antibiotic-resistant pathogenic bacteria. A report on the Rockefeller University Workshop.
The New England journal of medicine 1994;330(17):1247-51.
1994: Hermínia de Lencastre; I Couto; I Santos; J Melo-Cristino; A Torres-Pereira; Alexander Tomasz
Methicillin-resistant Staphylococcus aureus disease in a Portuguese hospital: characterization of clonal types by a combination of DNA typing methods.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1994;13(1):64-73.
1994: Hermínia de Lencastre; Boudewijn L M De Jonge; P R Matthews; Alexander Tomasz
Molecular aspects of methicillin resistance in Staphylococcus aureus.
The Journal of antimicrobial chemotherapy 1994;33(1):7-24.
1993: A Ornelas-Soares; Hermínia de Lencastre; Boudewijn L M De Jonge; D Gage; Y S Chang; Alexander Tomasz
The peptidoglycan composition of a Staphylococcus aureus mutant selected for reduced methicillin resistance.
The Journal of biological chemistry 1993;268(35):26268-72.
1993: S Soares; K G Kristinsson; J M Musser; Alexander Tomasz
Evidence for the introduction of a multiresistant clone of serotype 6B Streptococcus pneumoniae from Spain to Iceland in the late 1980s.
The Journal of infectious diseases 1993;168(1):158-63.
1993: Boudewijn L M De Jonge; T Sidow; Y S Chang; Harald Labischinski; B Berger-Bachi; Douglas A Gage; Alexander Tomasz
Altered muropeptide composition in Staphylococcus aureus strains with an inactivated femA locus.
Journal of bacteriology 1993;175(9):2779-82.
1993: P Cottagnoud; Alexander Tomasz
Triggering of pneumococcal autolysis by lysozyme.
The Journal of infectious diseases 1993;167(3):684-90.
1993: Boudewijn L M De Jonge; Alexander Tomasz
Abnormal peptidoglycan produced in a methicillin-resistant strain of Staphylococcus aureus grown in the presence of methicillin: functional role for penicillin-binding protein 2A in cell wall synthesis.
Antimicrobial agents and chemotherapy 1993;37(2):342-6.
1993: Hermínia de Lencastre; A M Figueiredo; Alexander Tomasz
Genetic control of population structure in heterogeneous strains of methicillin resistant Staphylococcus aureus.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1993;12 Suppl 1():S13-8.
1992: Anatoly Severin; C Schuster; Regine Hakenbeck; Alexander Tomasz
Altered murein composition in a DD-carboxypeptidase mutant of Streptococcus pneumoniae.
Journal of bacteriology 1992;174(15):5152-5.
1992: T Oshida; Alexander Tomasz
Isolation and characterization of a Tn551-autolysis mutant of Staphylococcus aureus.
Journal of bacteriology 1992;174(15):4952-9.
1992: R Munoz; J M Musser; Marilyn J Crain; David E Briles; A Marton; A J Parkinson; U Sorensen; Alexander Tomasz
Geographic distribution of penicillin-resistant clones of Streptococcus pneumoniae: characterization by penicillin-binding protein profile, surface protein A typing, and multilocus enzyme analysis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1992;15(1):112-8.
1992: Boudewijn L M De Jonge; Y S Chang; D Gage; Alexander Tomasz
Peptidoglycan composition of a highly methicillin-resistant Staphylococcus aureus strain. The role of penicillin binding protein 2A.
The Journal of biological chemistry 1992;267(16):11248-54.
1992: Boudewijn L M De Jonge; Y S Chang; D Gage; Alexander Tomasz
Peptidoglycan composition in heterogeneous Tn551 mutants of a methicillin-resistant Staphylococcus aureus strain.
The Journal of biological chemistry 1992;267(16):11255-9.
1992: A M Figueiredo; J D Connor; Anatoly Severin; M V Vaz Pato; Alexander Tomasz
A pneumococcal clinical isolate with high-level resistance to cefotaxime and ceftriaxone.
Antimicrobial agents and chemotherapy 1992;36(4):886-9.
1992: Gary J Noel; Barry N Kreiswirth; P J Edelson; M Nesin; Steven Projan; William Eisner; D J Bauer; Hermínia de Lencastre; A M sa Figueiredo; Alexander Tomasz
Multiple methicillin-resistant Staphylococcus aureus strains as a cause for a single outbreak of severe disease in hospitalized neonates.
The Pediatric infectious disease journal 1992;11(3):184-8.
1991: A M Figueiredo; E Ha; Barry N Kreiswirth; Hermínia de Lencastre; G J Noel; L Senterfit; Alexander Tomasz
In vivo stability of heterogeneous expression classes in clinical isolates of methicillin-resistant staphylococci.
The Journal of infectious diseases 1991;164(5):883-7.
1991: Hermínia de Lencastre; A M Sá Figueiredo; C Urban; J Rahal; Alexander Tomasz
Multiple mechanisms of methicillin resistance and improved methods for detection in clinical isolates of Staphylococcus aureus.
Antimicrobial agents and chemotherapy 1991;35(4):632-9.
1991: A Marton; M Gulyas; R Munoz; Alexander Tomasz
Extremely high incidence of antibiotic resistance in clinical isolates of Streptococcus pneumoniae in Hungary.
The Journal of infectious diseases 1991;163(3):542-8.
1991: Boudewijn L M De Jonge; Hermínia de Lencastre; Alexander Tomasz
Suppression of autolysis and cell wall turnover in heterogeneous Tn551 mutants of a methicillin-resistant Staphylococcus aureus strain.
Journal of bacteriology 1991;173(3):1105-10.
1991: Alexander Tomasz; S Nachman; H Leaf
Stable classes of phenotypic expression in methicillin-resistant clinical isolates of staphylococci.
Antimicrobial agents and chemotherapy 1991;35(1):124-9.
1990: H Laitinen; Alexander Tomasz
Changes in composition of peptidoglycan during maturation of the cell wall in pneumococci.
Journal of bacteriology 1990;172(10):5961-7.
1990: P Matthews; Alexander Tomasz
Insertional inactivation of the mec gene in a transposon mutant of a methicillin-resistant clinical isolate of Staphylococcus aureus.
Antimicrobial agents and chemotherapy 1990;34(9):1777-9.
1990: J Garcia-Bustos; Alexander Tomasz
A biological price of antibiotic resistance: major changes in the peptidoglycan structure of penicillin-resistant pneumococci.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(14):5415-9.
1990: Z Markiewicz; Alexander Tomasz
Protein-bound choline is released from the pneumococcal autolytic enzyme during adsorption of the enzyme to cell wall particles.
Journal of bacteriology 1990;172(5):2241-4.
1990: Elaine I Tuomanen; Alexander Tomasz
Mechanism of phenotypic tolerance of nongrowing pneumococci to beta-lactam antibiotics.
Scandinavian journal of infectious diseases. Supplementum 1990;74():102-12.
1990: P Moreillon; Z Markiewicz; S Nachman; Alexander Tomasz
Two bactericidal targets for penicillin in pneumococci: autolysis-dependent and autolysis-independent killing mechanisms.
Antimicrobial agents and chemotherapy 1990;34(1):33-9.
1989: Alexander Tomasz; K Saukkonen
The nature of cell wall-derived inflammatory components of pneumococci.
The Pediatric infectious disease journal 1989;8(12):902-3.
1989: Alexander Tomasz; H B Drugeon; Hermínia de Lencastre; D Jabes; L McDougall; J Bille
New mechanism for methicillin resistance in Staphylococcus aureus: clinical isolates that lack the PBP 2a gene and contain normal penicillin-binding proteins with modified penicillin-binding capacity.
Antimicrobial agents and chemotherapy 1989;33(11):1869-74.
1989: Z Markiewicz; Alexander Tomasz
Variation in penicillin-binding protein patterns of penicillin-resistant clinical isolates of pneumococci.
Journal of clinical microbiology 1989;27(3):405-10.
1989: D Jabes; Alexander Tomasz
Lytic and bactericidal activity of FCE 22101.
The Journal of antimicrobial chemotherapy 1989;23 Suppl C():75-83.
1989: Gianni Pozzi; Marco R Oggioni; Alexander Tomasz
DNA probe for identification of Streptococcus pneumoniae.
Journal of clinical microbiology 1989;27(2):370-2.
1989: K Murakami; Alexander Tomasz
Involvement of multiple genetic determinants in high-level methicillin resistance in Staphylococcus aureus.
Journal of bacteriology 1989;171(2):874-9.
1989: D Jabes; S Nachman; Alexander Tomasz
Penicillin-binding protein families: evidence for the clonal nature of penicillin resistance in clinical isolates of pneumococci.
The Journal of infectious diseases 1989;159(1):16-25.
1989: J Garcia-Bustos; Alexander Tomasz
Mechanism of pneumococcal cell wall degradation in vitro and in vivo.
Journal of bacteriology 1989;171(1):114-9.
1988: Alexander Tomasz; P Moreillon; Gianni Pozzi
Insertional inactivation of the major autolysin gene of Streptococcus pneumoniae.
Journal of bacteriology 1988;170(12):5931-4.
1988: P Moreillon; Alexander Tomasz
Penicillin resistance and defective lysis in clinical isolates of pneumococci: evidence for two kinds of antibiotic pressure operating in the clinical environment.
The Journal of infectious diseases 1988;157(6):1150-7.
1988: J F Garcia-Bustos; Brian T Chait; Alexander Tomasz
Altered peptidoglycan structure in a pneumococcal transformant resistant to penicillin.
Journal of bacteriology 1988;170(5):2143-7.
1988: Elaine I Tuomanen; Z Markiewicz; Alexander Tomasz
Autolysis-resistant peptidoglycan of anomalous composition in amino-acid-starved Escherichia coli.
Journal of bacteriology 1988;170(3):1373-6.
1987: J F Garcia-Bustos; Brian T Chait; Alexander Tomasz
Structure of the peptide network of pneumococcal peptidoglycan.
The Journal of biological chemistry 1987;262(32):15400-5.
1987: H H Liu; Alexander Tomasz
A mutant of Streptococcus pneumoniae that exhibits thermosensitive penicillin tolerance and the paradoxical effect.
Journal of general microbiology 1987;133(6):1611-8.
1987: Elaine I Tuomanen; B Hengstler; R Rich; M A Bray; O Zak; Alexander Tomasz
Nonsteroidal anti-inflammatory agents in the therapy for experimental pneumococcal meningitis.
The Journal of infectious diseases 1987;155(5):985-90.
1986: Elaine I Tuomanen; B Hengstler; O Zak; Alexander Tomasz
Induction of meningeal inflammation by diverse bacterial cell walls.
European journal of clinical microbiology 1986;5(6):682-4.
1986: Elaine I Tuomanen; B Hengstler; O Zak; Alexander Tomasz
The role of complement in inflammation during experimental pneumococcal meningitis.
Microbial pathogenesis 1986;1(1):15-32.
1985: Elaine I Tuomanen; H Liu; B Hengstler; O Zak; Alexander Tomasz
The induction of meningeal inflammation by components of the pneumococcal cell wall.
The Journal of infectious diseases 1985;151(5):859-68.
1985: Elaine I Tuomanen; Alexander Tomasz; B Hengstler; O Zak
The relative role of bacterial cell wall and capsule in the induction of inflammation in pneumococcal meningitis.
The Journal of infectious diseases 1985;151(3):535-40.