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Maria Tomasz

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Jill Bargonetti; Elise Champeil; Maria Tomasz
Differential toxicity of DNA adducts of mitomycin C.
Manuel Paz; Sweta Ladwa; Elise Champeil; Yanfeng Liu; Sara Rockwell; Ernest K Boamah; Jill Bargonetti; John Callahan; John Roach; Maria Tomasz
Mapping DNA adducts of mitomycin C and decarbamoyl mitomycin C in cell lines using liquid chromatography/ electrospray tandem mass spectrometry.
Elise Champeil; Manuel Paz; Sweta Ladwa; Cristina Clement; Andrzej Zatorski; Maria Tomasz
Synthesis of an oligodeoxyribonucleotide adduct of mitomycin C by the postoligomerization method via a triamino mitosene.

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All Publications

2010: Jill Bargonetti; Elise Champeil; Maria Tomasz
Differential toxicity of DNA adducts of mitomycin C.
Journal of nucleic acids 2010;2010():.
2008: Manuel Paz; Sweta Ladwa; Elise Champeil; Yanfeng Liu; Sara Rockwell; Ernest K Boamah; Jill Bargonetti; John Callahan; John Roach; Maria Tomasz
Mapping DNA adducts of mitomycin C and decarbamoyl mitomycin C in cell lines using liquid chromatography/ electrospray tandem mass spectrometry.
Chemical research in toxicology 2008;21(12):2370-8.
2008: Elise Champeil; Manuel Paz; Sweta Ladwa; Cristina Clement; Andrzej Zatorski; Maria Tomasz
Synthesis of an oligodeoxyribonucleotide adduct of mitomycin C by the postoligomerization method via a triamino mitosene.
Journal of the American Chemical Society 2008;130(29):9556-65.
2007: Ernest K Boamah; David E White; Kathryn E Talbott; Nicoleta C Arva; Daniel Berman; Maria Tomasz; Jill Bargonetti
Mitomycin-DNA adducts induce p53-dependent and p53-independent cell death pathways.
ACS chemical biology 2007;2(6):399-407.
2005: Christopher D Utzat; Cristina Clement; Leilani A Ramos; Arunangshu Das; Maria Tomasz; Ashis K Basu
DNA adduct of the mitomycin C metabolite 2,7-diaminomitosene is a nontoxic and nonmutagenic DNA lesion in vitro and in vivo.
Chemical research in toxicology 2005;18(2):213-23.
2005: Helen A Seow; Michael F Belcourt; Philip G Penketh; William F Hodnick; Maria Tomasz; Sara Rockwell; Alan C Sartorelli
Nuclear localization of NADPH:cytochrome c (P450) reductase enhances the cytotoxicity of mitomycin C to Chinese hamster ovary cells.
Molecular pharmacology 2005;67(2):417-23.
2004: Helen A Seow; Philip G Penketh; Michael F Belcourt; Maria Tomasz; Sara Rockwell; Alan C Sartorelli
Nuclear overexpression of NAD(P)H:quinone oxidoreductase 1 in Chinese hamster ovary cells increases the cytotoxicity of mitomycin C under aerobic and hypoxic conditions.
The Journal of biological chemistry 2004;279(30):31606-12.
2004: Manuel Paz; Gopinatha Suresh ; Mark Glover; Michael J Waring; Maria Tomasz
Mitomycin dimers: polyfunctional cross-linkers of DNA.
Journal of medicinal chemistry 2004;47(12):3308-19.
2003: Kathleen M Holtz; Sara Rockwell; Maria Tomasz; Alan C Sartorelli
Nuclear overexpression of NADH:cytochrome b5 reductase activity increases the cytotoxicity of mitomycin C (MC) and the total number of MC-DNA adducts in Chinese hamster ovary cells.
The Journal of biological chemistry 2003;278(7):5029-34.
2002: Yolanda Palom; Gopinatha Suresh ; Li-Qun Tang; Manuel Paz; Steven M Musser; Sara Rockwell; Maria Tomasz
Relative toxicities of DNA cross-links and monoadducts: new insights from studies of decarbamoyl mitomycin C and mitomycin C.
Chemical research in toxicology 2002;15(11):1398-406.
2002: Tarek Abbas; Magali Olivier; Jaqueline Lopez; Sandra Houser; Gu Xiao; Gopinatha Suresh ; Maria Tomasz; Jill Bargonetti
Differential activation of p53 by the various adducts of mitomycin C.
The Journal of biological chemistry 2002;277(43):40513-9.
2001: Manuel Paz; Maria Tomasz
Reductive activation of mitomycin A by thiols.
Organic letters 2001;3(18):2789-92.
2001: G Subramaniam; Manuel Paz; Gopinatha Suresh ; A Das; Yolanda Palom; Cristina Clement; Dinshaw J Patel; Maria Tomasz
Solution structure of a guanine-N7-linked complex of the mitomycin C metabolite 2,7-diaminomitosene and DNA. Basis of sequence selectivity.
Biochemistry 2001;40(35):10473-84.
2001: Manuel Paz; A Das; Yolanda Palom; Q Y He; Maria Tomasz
Selective activation of mitomycin A by thiols to form DNA cross-links and monoadducts: biochemical basis for the modulation of mitomycin cytotoxicity by the quinone redox potential.
Journal of medicinal chemistry 2001;44(17):2834-42.
2001: Yolanda Palom; Michael F Belcourt; Li-Qun Tang; S S Mehta; Alan C Sartorelli; Chris A Pritsos; K L Pritsos; S Rockwell; Maria Tomasz
Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol.
Biochemical pharmacology 2001;61(12):1517-29.
2000: Yolanda Palom; Michael F Belcourt; Steven M Musser; Alan C Sartorelli; S Rockwell; Maria Tomasz
Structure of adduct X, the last unknown of the six major DNA adducts of mitomycin C formed in EMT6 mouse mammary tumor cells.
Chemical research in toxicology 2000;13(6):479-88.
1999: Manuel Paz; T A Das; Maria Tomasz
Mitomycin C linked to DNA minor groove binding agents: synthesis, reductive activation, DNA binding and cross-linking properties and in vitro antitumor activity.
Bioorganic & medicinal chemistry 1999;7(12):2713-26.
1999: A Das; K S Tang; S Gopalakrishnan; M J Waring; Maria Tomasz
Reactivity of guanine at m5CpG steps in DNA: evidence for electronic effects transmitted through the base pairs.
Chemistry & biology 1999;6(7):461-71.
1998: Yolanda Palom; R Lipman; Steven M Musser; Maria Tomasz
A mitomycin-N6-deoxyadenosine adduct isolated from DNA.
Chemical research in toxicology 1998;11(3):203-10.
1998: Yolanda Palom; Michael F Belcourt; Gopinatha Suresh ; H Arai; M Kasai; Alan C Sartorelli; S Rockwell; Maria Tomasz
Formation of a major DNA adduct of the mitomycin metabolite 2,7-diaminomitosene in EMT6 mouse mammary tumor cells treated with mitomycin C.
Oncology research 1998;10(10):509-21.
1998: Leilani A Ramos; R Lipman; Maria Tomasz; Ashis K Basu
The major mitomycin C-DNA monoadduct is cytotoxic but not mutagenic in Escherichia coli.
Chemical research in toxicology 1998;11(1):64-9.
1997: Gopinatha Suresh ; R Lipman; Jeff Cummings; Maria Tomasz
Mitomycin C-DNA adducts generated by DT-diaphorase. Revised mechanism of the enzymatic reductive activation of mitomycin C.
Biochemistry 1997;36(46):14128-36.
1997: Maria Tomasz; Yolanda Palom
The mitomycin bioreductive antitumor agents: cross-linking and alkylation of DNA as the molecular basis of their activity.
Pharmacology & therapeutics 1997;76(1-3):73-87.
1997: H Maruenda; Maria Tomasz
Antisense sequence-directed cross-linking of RNA oligonucleotides by mitomycin.
Anti-cancer drug design 1997;12(6):473-9.
1996: H Maruenda; Maria Tomasz
Antisense sequence-directed cross-linking of DNA oligonucleotides by mitomycin C.
Bioconjugate chemistry 1996;7(5):541-4.
1996: S M Rink; R Lipman; S C Alley; Paul B Hopkins; Maria Tomasz
Bending of DNA by the mitomycin C-induced, GpG intrastrand cross-link.
Chemical research in toxicology 1996;9(2):382-9.
1995: Maria Tomasz
Mitomycin C: small, fast and deadly (but very selective).
Chemistry & biology 1995;2(9):575-9.
1995: W S Johnson; Q Y He; Maria Tomasz
Selective recognition of the m5CpG dinucleotide sequence in DNA by mitomycin C for alkylation and cross-linking.
Bioorganic & medicinal chemistry 1995;3(6):851-60.
1995: M Sastry; R Fiala; R Lipman; Maria Tomasz; Dinshaw J Patel
Solution structure of the monoalkylated mitomycin C-DNA complex.
Journal of molecular biology 1995;247(2):338-59.
1995: G S Kumar; Q Y He; D Behr-Ventura; Maria Tomasz
Binding of 2,7-diaminomitosene to DNA: model for the precovalent recognition of DNA by activated mitomycin C.
Biochemistry 1995;34(8):2662-71.
1995: D Gargiulo; G S Kumar; S S Musser; Maria Tomasz
Structural and function modification of DNA by mitomycin C. Mechanism of the DNA sequence specificity of mitomycins.
Nucleic acids symposium series 1995;(34):169-70.
1994: M Sharma; Q Y He; Maria Tomasz
Effects of glutathione on alkylation and cross-linking of DNA by mitomycin C. Isolation of a ternary glutathione-mitomycin-DNA adduct.
Chemical research in toxicology 1994;7(3):401-7.
1994: M Sharma; Maria Tomasz
Conjugation of glutathione and other thiols with bioreductively activated mitomycin C. Effect of thiols on the reductive activation rate.
Chemical research in toxicology 1994;7(3):390-400.
1994: Maria Tomasz
DNA adducts of the mitomycins.
IARC scientific publications 1994;(125):349-57.
1994: Alan C Sartorelli; William F Hodnick; Michael F Belcourt; Maria Tomasz; B Haffty; J J Fischer; S Rockwell
Mitomycin C: a prototype bioreductive agent.
Oncology research 1994;6(10-11):501-8.
1993: R Bizanek; D Chowdary; H Arai; M Kasai; C S Hughes; Alan C Sartorelli; S Rockwell; Maria Tomasz
Adducts of mitomycin C and DNA in EMT6 mouse mammary tumor cells: effects of hypoxia and dicumarol on adduct patterns.
Cancer research 1993;53(21):5127-34.
1993: S Rockwell; Alan C Sartorelli; Maria Tomasz; K A Kennedy
Cellular pharmacology of quinone bioreductive alkylating agents.
Cancer metastasis reviews 1993;12(2):165-76.
1993: Ashis K Basu; C J Hanrahan; S A Malia; Shiv Kumar; R Bizanek; Maria Tomasz
Effect of site-specifically located mitomycin C-DNA monoadducts on in vitro DNA synthesis by DNA polymerases.
Biochemistry 1993;32(18):4708-18.
1993: Shiv Kumar; W S Johnson; Maria Tomasz
Orientation isomers of the mitomycin C interstrand cross-link in non-self-complementary DNA. Differential effect of the two isomers on restriction endonuclease cleavage at a nearby site.
Biochemistry 1993;32(5):1364-72.
1993: Alan C Sartorelli; Maria Tomasz; S Rockwell
Studies on the mechanism of the cytotoxic action of the mitomycin antibiotics in hypoxic and oxygenated EMT6 cells.
Advances in enzyme regulation 1993;33():3-17.
1992: R Bizanek; B F McGuinness; K Nakanishi; Maria Tomasz
Isolation and structure of an intrastrand cross-link adduct of mitomycin C and DNA.
Biochemistry 1992;31(12):3084-91.
1992: Shiv Kumar; R Lipman; Maria Tomasz
Recognition of specific DNA sequences by mitomycin C for alkylation.
Biochemistry 1992;31(5):1399-407.
1991: B F McGuinness; R Lipman; J Goldstein; K Nakanishi; Maria Tomasz
Reductive alkylation of DNA by mitomycin A, a mitomycin with high redox potential.
Biochemistry 1991;30(26):6444-53.
1991: Maria Tomasz; C S Hughes; D Chowdary; S R Keyes; R Lipman; Alan C Sartorelli; S Rockwell
Isolation, identification, and assay of [3H]-porfiromycin adducts of EMT6 mouse mammary tumor cell DNA: effects of hypoxia and dicumarol on adduct patterns.
Cancer communications 1991;3(7):213-23.
1990: H Borowy-Borowski; R Lipman; Maria Tomasz
Recognition between mitomycin C and specific DNA sequences for cross-link formation.
Biochemistry 1990;29(12):2999-3006.
1990: H Borowy-Borowski; R Lipman; D Chowdary; Maria Tomasz
Duplex oligodeoxyribonucleotides cross-linked by mitomycin C at a single site: synthesis, properties, and cross-link reversibility.
Biochemistry 1990;29(12):2992-9.
1990: David G Norman; D Live; M Sastry; R Lipman; Brian E Hingerty; Maria Tomasz; Suse Broyde; Dinshaw J Patel
NMR and computational characterization of mitomycin cross-linked to adjacent deoxyguanosines in the minor groove of the d(T-A-C-G-T-A).d(T-A-C-G-T-A) duplex.
Biochemistry 1990;29(11):2861-75.
1988: A K Chawla; Maria Tomasz
Interaction of the antitumor antibiotic mitomycin C with Z-DNA.
Journal of biomolecular structure & dynamics 1988;6(3):459-70.
1988: Maria Tomasz; A K Chawla; R Lipman
Mechanism of monofunctional and bifunctional alkylation of DNA by mitomycin C.
Biochemistry 1988;27(9):3182-7.
1987: Maria Tomasz; R Lipman; M S Lee; G L Verdine; K Nakanishi
Reaction of acid-activated mitomycin C with calf thymus DNA and model guanines: elucidation of the base-catalyzed degradation of N7-alkylguanine nucleosides.
Biochemistry 1987;26(7):2010-27.
1987: Maria Tomasz; R Lipman; D Chowdary; J Pawlak; G L Verdine; K Nakanishi
Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA.
Science (New York, N.Y.) 1987;235(4793):1204-8.
1986: Maria Tomasz; D Chowdary; R Lipman; S Shimotakahara; D Veiro; V Walker; G L Verdine
Reaction of DNA with chemically or enzymatically activated mitomycin C: isolation and structure of the major covalent adduct.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(18):6702-6.
1986: Maria Tomasz; R Lipman; G L Verdine; K Nakanishi
Reassignment of the guanine-binding mode of reduced mitomycin C.
Biochemistry 1986;25(15):4337-44.
1981: Maria Tomasz; R Lipman
Reductive metabolism and alkylating activity of mitomycin C induced by rat liver microsomes.
Biochemistry 1981;20(17):5056-61.