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Maria Tomasz
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Network (preview)
13
Rockwell, Sara
11
Sartorelli, Alan
8
Paz, Manuel
8
Palom, Yolanda
6
Belcourt, Michael
6
Suresh , Gopinatha
3
Lipman, R
3
Musser, Steven
3
Kumar, Shiv
3
Bargonetti, Jill
3
Basu, Ashis
3
Patel, Dinshaw
2
Penketh, Philip
2
Hodnick, William
2
Ramos, Leilani
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All Publications
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2008: Paz Manuel M; Ladwa Sweta; Champeil Elise; Liu Yanfeng; Rockwell Sara; Boamah Ernest K; Bargonetti Jill; Callahan John; Roach John; Tomasz Maria
Mapping DNA adducts of mitomycin C and decarbamoyl mitomycin C in cell lines using liquid chromatography/ electrospray tandem mass spectrometry.
Chemical research in toxicology 2008;21(12):2370-8.
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2008: Champeil Elise; Paz Manuel M; Ladwa Sweta; Clement Cristina C; Zatorski Andrzej; Tomasz Maria
Synthesis of an oligodeoxyribonucleotide adduct of mitomycin C by the postoligomerization method via a triamino mitosene.
Journal of the American Chemical Society 2008;130(29):9556-65.
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2007: Boamah Ernest K; White David E; Talbott Kathryn E; Arva Nicoleta C; Berman Daniel; Tomasz Maria; Bargonetti Jill
Mitomycin-DNA adducts induce p53-dependent and p53-independent cell death pathways.
ACS chemical biology 2007;2(6):399-407.
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2005: Utzat Christopher D; Clement Cristina C; Ramos Leilani A; Das Arunangshu; Tomasz Maria; Basu Ashis K
DNA adduct of the mitomycin C metabolite 2,7-diaminomitosene is a nontoxic and nonmutagenic DNA lesion in vitro and in vivo.
Chemical research in toxicology 2005;18(2):213-23.
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2005: Seow Helen A; Belcourt Michael F; Penketh Philip G; Hodnick William F; Tomasz Maria; Rockwell Sara; Sartorelli Alan C
Nuclear localization of NADPH:cytochrome c (P450) reductase enhances the cytotoxicity of mitomycin C to Chinese hamster ovary cells.
Molecular pharmacology 2005;67(2):417-23.
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2004: Seow Helen A; Penketh Philip G; Belcourt Michael F; Tomasz Maria; Rockwell Sara; Sartorelli Alan C
Nuclear overexpression of NAD(P)H:quinone oxidoreductase 1 in Chinese hamster ovary cells increases the cytotoxicity of mitomycin C under aerobic and hypoxic conditions.
The Journal of biological chemistry 2004;279(30):31606-12.
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2004: Paz Manuel M; Kumar Gopinatha Suresh; Glover Mark; Waring Michael J; Tomasz Maria
Mitomycin dimers: polyfunctional cross-linkers of DNA.
Journal of medicinal chemistry 2004;47(12):3308-19.
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2003: Holtz Kathleen M; Rockwell Sara; Tomasz Maria; Sartorelli Alan C
Nuclear overexpression of NADH:cytochrome b5 reductase activity increases the cytotoxicity of mitomycin C (MC) and the total number of MC-DNA adducts in Chinese hamster ovary cells.
The Journal of biological chemistry 2003;278(7):5029-34.
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2002: Palom Yolanda; Suresh Kumar Gopinatha; Tang Li-Qian; Paz Manuel M; Musser Steven M; Rockwell Sara; Tomasz Maria
Relative toxicities of DNA cross-links and monoadducts: new insights from studies of decarbamoyl mitomycin C and mitomycin C.
Chemical research in toxicology 2002;15(11):1398-406.
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2002: Abbas Tarek; Olivier Magali; Lopez Jaqueline; Houser Sandra; Xiao Gu; Kumar Gopinatha Suresh; Tomasz Maria; Bargonetti Jill
Differential activation of p53 by the various adducts of mitomycin C.
The Journal of biological chemistry 2002;277(43):40513-9.
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2001: Paz M M; Tomasz M
Reductive activation of mitomycin A by thiols.
Organic letters 2001;3(18):2789-92.
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2001: Subramaniam G; Paz M M; Suresh Kumar G; Das A; Palom Y; Clement C C; Patel D J; Tomasz M
Solution structure of a guanine-N7-linked complex of the mitomycin C metabolite 2,7-diaminomitosene and DNA. Basis of sequence selectivity.
Biochemistry 2001;40(35):10473-84.
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2001: Paz M M; Das A; Palom Y; He Q Y; Tomasz M
Selective activation of mitomycin A by thiols to form DNA cross-links and monoadducts: biochemical basis for the modulation of mitomycin cytotoxicity by the quinone redox potential.
Journal of medicinal chemistry 2001;44(17):2834-42.
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2001: Palom Y; Belcourt M F; Tang L Q; Mehta S S; Sartorelli A C; Pritsos C A; Pritsos K L; Rockwell S; Tomasz M
Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol.
Biochemical pharmacology 2001;61(12):1517-29.
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2000: Palom Y; Belcourt M F; Musser S M; Sartorelli A C; Rockwell S; Tomasz M
Structure of adduct X, the last unknown of the six major DNA adducts of mitomycin C formed in EMT6 mouse mammary tumor cells.
Chemical research in toxicology 2000;13(6):479-88.
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1999: Paz M M; Das T A; Tomasz M
Mitomycin C linked to DNA minor groove binding agents: synthesis, reductive activation, DNA binding and cross-linking properties and in vitro antitumor activity.
Bioorganic & medicinal chemistry 1999;7(12):2713-26.
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1999: Das A; Tang K S; Gopalakrishnan S; Waring M J; Tomasz M
Reactivity of guanine at m5CpG steps in DNA: evidence for electronic effects transmitted through the base pairs.
Chemistry & biology 1999;6(7):461-71.
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1998: Palom Y; Lipman R; Musser S M; Tomasz M
A mitomycin-N6-deoxyadenosine adduct isolated from DNA.
Chemical research in toxicology 1998;11(3):203-10.
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1998: Ramos L A; Lipman R; Tomasz M; Basu A K
The major mitomycin C-DNA monoadduct is cytotoxic but not mutagenic in Escherichia coli.
Chemical research in toxicology 1998;11(1):64-9.
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1998: Palom Y; Belcourt M F; Kumar G S; Arai H; Kasai M; Sartorelli A C; Rockwell S; Tomasz M
Formation of a major DNA adduct of the mitomycin metabolite 2,7-diaminomitosene in EMT6 mouse mammary tumor cells treated with mitomycin C.
Oncology research 1998;10(10):509-21.
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1997: Suresh Kumar G; Lipman R; Cummings J; Tomasz M
Mitomycin C-DNA adducts generated by DT-diaphorase. Revised mechanism of the enzymatic reductive activation of mitomycin C.
Biochemistry 1997;36(46):14128-36.
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1997: Tomasz M; Palom Y
The mitomycin bioreductive antitumor agents: cross-linking and alkylation of DNA as the molecular basis of their activity.
Pharmacology & therapeutics 1997;76(1-3):73-87.
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1997: Maruenda H; Tomasz M
Antisense sequence-directed cross-linking of RNA oligonucleotides by mitomycin.
Anti-cancer drug design 1997;12(6):473-9.
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1996: Maruenda H; Tomasz M
Antisense sequence-directed cross-linking of DNA oligonucleotides by mitomycin C.
Bioconjugate chemistry 1996;7(5):541-4.
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1996: Rink S M; Lipman R; Alley S C; Hopkins P B; Tomasz M
Bending of DNA by the mitomycin C-induced, GpG intrastrand cross-link.
Chemical research in toxicology 1996;9(2):382-9.
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1995: Tomasz M
Mitomycin C: small, fast and deadly (but very selective).
Chemistry & biology 1995;2(9):575-9.
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1995: Johnson W S; He Q Y; Tomasz M
Selective recognition of the m5CpG dinucleotide sequence in DNA by mitomycin C for alkylation and cross-linking.
Bioorganic & medicinal chemistry 1995;3(6):851-60.
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1995: Sastry M; Fiala R; Lipman R; Tomasz M; Patel D J
Solution structure of the monoalkylated mitomycin C-DNA complex.
Journal of molecular biology 1995;247(2):338-59.
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1995: Kumar G S; He Q Y; Behr-Ventura D; Tomasz M
Binding of 2,7-diaminomitosene to DNA: model for the precovalent recognition of DNA by activated mitomycin C.
Biochemistry 1995;34(8):2662-71.
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1995: Gargiulo D; Kumar G S; Musser S S; Tomasz M
Structural and function modification of DNA by mitomycin C. Mechanism of the DNA sequence specificity of mitomycins.
Nucleic acids symposium series 1995;(34):169-70.
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1994: Sharma M; He Q Y; Tomasz M
Effects of glutathione on alkylation and cross-linking of DNA by mitomycin C. Isolation of a ternary glutathione-mitomycin-DNA adduct.
Chemical research in toxicology 1994;7(3):401-7.
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1994: Sharma M; Tomasz M
Conjugation of glutathione and other thiols with bioreductively activated mitomycin C. Effect of thiols on the reductive activation rate.
Chemical research in toxicology 1994;7(3):390-400.
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1994: Tomasz M
DNA adducts of the mitomycins.
IARC scientific publications 1994;(125):349-57.
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1994: Sartorelli A C; Hodnick W F; Belcourt M F; Tomasz M; Haffty B; Fischer J J; Rockwell S
Mitomycin C: a prototype bioreductive agent.
Oncology research 1994;6(10-11):501-8.
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1993: Bizanek R; Chowdary D; Arai H; Kasai M; Hughes C S; Sartorelli A C; Rockwell S; Tomasz M
Adducts of mitomycin C and DNA in EMT6 mouse mammary tumor cells: effects of hypoxia and dicumarol on adduct patterns.
Cancer research 1993;53(21):5127-34.
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1993: Rockwell S; Sartorelli A C; Tomasz M; Kennedy K A
Cellular pharmacology of quinone bioreductive alkylating agents.
Cancer metastasis reviews 1993;12(2):165-76.
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1993: Basu A K; Hanrahan C J; Malia S A; Kumar S; Bizanek R; Tomasz M
Effect of site-specifically located mitomycin C-DNA monoadducts on in vitro DNA synthesis by DNA polymerases.
Biochemistry 1993;32(18):4708-18.
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1993: Kumar S; Johnson W S; Tomasz M
Orientation isomers of the mitomycin C interstrand cross-link in non-self-complementary DNA. Differential effect of the two isomers on restriction endonuclease cleavage at a nearby site.
Biochemistry 1993;32(5):1364-72.
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1993: Sartorelli A C; Tomasz M; Rockwell S
Studies on the mechanism of the cytotoxic action of the mitomycin antibiotics in hypoxic and oxygenated EMT6 cells.
Advances in enzyme regulation 1993;33():3-17.
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1992: Bizanek R; McGuinness B F; Nakanishi K; Tomasz M
Isolation and structure of an intrastrand cross-link adduct of mitomycin C and DNA.
Biochemistry 1992;31(12):3084-91.
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1992: Kumar S; Lipman R; Tomasz M
Recognition of specific DNA sequences by mitomycin C for alkylation.
Biochemistry 1992;31(5):1399-407.
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1991: McGuinness B F; Lipman R; Goldstein J; Nakanishi K; Tomasz M
Reductive alkylation of DNA by mitomycin A, a mitomycin with high redox potential.
Biochemistry 1991;30(26):6444-53.
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1991: Tomasz M; Hughes C S; Chowdary D; Keyes S R; Lipman R; Sartorelli A C; Rockwell S
Isolation, identification, and assay of [3H]-porfiromycin adducts of EMT6 mouse mammary tumor cell DNA: effects of hypoxia and dicumarol on adduct patterns.
Cancer communications 1991;3(7):213-23.
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1990: Norman D; Live D; Sastry M; Lipman R; Hingerty B E; Tomasz M; Broyde S; Patel D J
NMR and computational characterization of mitomycin cross-linked to adjacent deoxyguanosines in the minor groove of the d(T-A-C-G-T-A).d(T-A-C-G-T-A) duplex.
Biochemistry 1990;29(11):2861-75.
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1990: Borowy-Borowski H; Lipman R; Tomasz M
Recognition between mitomycin C and specific DNA sequences for cross-link formation.
Biochemistry 1990;29(12):2999-3006.
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1990: Borowy-Borowski H; Lipman R; Chowdary D; Tomasz M
Duplex oligodeoxyribonucleotides cross-linked by mitomycin C at a single site: synthesis, properties, and cross-link reversibility.
Biochemistry 1990;29(12):2992-9.
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1988: Chawla A K; Tomasz M
Interaction of the antitumor antibiotic mitomycin C with Z-DNA.
Journal of biomolecular structure & dynamics 1988;6(3):459-70.
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1988: Tomasz M; Chawla A K; Lipman R
Mechanism of monofunctional and bifunctional alkylation of DNA by mitomycin C.
Biochemistry 1988;27(9):3182-7.
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1987: Tomasz M; Lipman R; Lee M S; Verdine G L; Nakanishi K
Reaction of acid-activated mitomycin C with calf thymus DNA and model guanines: elucidation of the base-catalyzed degradation of N7-alkylguanine nucleosides.
Biochemistry 1987;26(7):2010-27.
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1987: Tomasz M; Lipman R; Chowdary D; Pawlak J; Verdine G L; Nakanishi K
Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA.
Science (New York, N.Y.) 1987;235(4793):1204-8.
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1986: Tomasz M; Chowdary D; Lipman R; Shimotakahara S; Veiro D; Walker V; Verdine G L
Reaction of DNA with chemically or enzymatically activated mitomycin C: isolation and structure of the major covalent adduct.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(18):6702-6.
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1986: Tomasz M; Lipman R; Verdine G L; Nakanishi K
Reassignment of the guanine-binding mode of reduced mitomycin C.
Biochemistry 1986;25(15):4337-44.
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1981: Tomasz M; Lipman R
Reductive metabolism and alkylating activity of mitomycin C induced by rat liver microsomes.
Biochemistry 1981;20(17):5056-61.
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