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Rose Tominovich

Research Profile

Anatomy

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Xenograft Model Antitumor Assays

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Holly K Koblish; Shuyuan Zhao; Carol F Franks; Robert R Donatelli; Rose Tominovich; Louis V Lafrance; Kristi A Leonard; Joan M Gushue; Daniel J Parks; Raul R Calvo; Karen L Milkiewicz; Juan José Marugán; Pierre Raboisson; Maxwell D Cummings; Bruce L Grasberger; Dana L Johnson; Tianbao Lu; Christopher Molloy; Anna C Maroney
Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo.
Chih Y Ho; Donald W Ludovici; Umar S M Maharoof; Jay Mei; Jan L Sechler; Robert W Tuman; Eric D Strobel; Laura Andraka; Hwa-Kwo Yen; Gregory C Leo; Jian Li; Harold Almond; Hong Lu; Ann DeVine; Rose Tominovich; Judith Baker; Stuart Emanuel; Robert H Gruninger; Steven A Middleton; Dana L Johnson; Robert Anthony Galemmo
(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells.
Stuart Emanuel; Robert H Gruninger; Angel Fuentes-Pesquera; Peter J Connolly; Jennifer A Seamon; Susan Hazel; Rose Tominovich; Beth Hollister; Cheryl Napier; Michael R D'Andrea; Michael Reuman; Gilles C Bignan; Robert W Tuman; Dana Johnson; David Moffatt; Mark Batchelor; Anne Foley; James O'Connell; Rodger Allen; Martin Perry; Linda Jolliffe; Steven A Middleton
A vascular endothelial growth factor receptor-2 kinase inhibitor potentiates the activity of the conventional chemotherapeutic agents paclitaxel and doxorubicin in tumor xenograft models.

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All Publications

2006: Holly K Koblish; Shuyuan Zhao; Carol F Franks; Robert R Donatelli; Rose Tominovich; Louis V Lafrance; Kristi A Leonard; Joan M Gushue; Daniel J Parks; Raul R Calvo; Karen L Milkiewicz; Juan José Marugán; Pierre Raboisson; Maxwell D Cummings; Bruce L Grasberger; Dana L Johnson; Tianbao Lu; Christopher Molloy; Anna C Maroney
Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo.
Molecular cancer therapeutics 2006;5(1):160-9.
2005: Chih Y Ho; Donald W Ludovici; Umar S M Maharoof; Jay Mei; Jan L Sechler; Robert W Tuman; Eric D Strobel; Laura Andraka; Hwa-Kwo Yen; Gregory C Leo; Jian Li; Harold Almond; Hong Lu; Ann DeVine; Rose Tominovich; Judith Baker; Stuart Emanuel; Robert H Gruninger; Steven A Middleton; Dana L Johnson; Robert Anthony Galemmo
(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells.
Journal of medicinal chemistry 2005;48(26):8163-73.
2004: Stuart Emanuel; Robert H Gruninger; Angel Fuentes-Pesquera; Peter J Connolly; Jennifer A Seamon; Susan Hazel; Rose Tominovich; Beth Hollister; Cheryl Napier; Michael R D'Andrea; Michael Reuman; Gilles C Bignan; Robert W Tuman; Dana Johnson; David Moffatt; Mark Batchelor; Anne Foley; James O'Connell; Rodger Allen; Martin Perry; Linda Jolliffe; Steven A Middleton
A vascular endothelial growth factor receptor-2 kinase inhibitor potentiates the activity of the conventional chemotherapeutic agents paclitaxel and doxorubicin in tumor xenograft models.
Molecular pharmacology 2004;66(3):635-47.
2004: Thomas Garrabrant; Robert W Tuman; Donald W Ludovici; Rose Tominovich; Richard L Simoneaux; Robert Anthony Galemmo; Dana L Johnson
Small molecule inhibitors of methionine aminopeptidase type 2 (MetAP-2).
Angiogenesis 2004;7(2):91-6.
2002: Jean-Pierre Bongartz; Raymond Stokbroekx; Marcel Van der Aa; Marcel Luyckx; Marc Willems; Marc Ceusters; Lieven Meerpoel; Gerda Smets; Tine Jansen; Walter Wouters; Charlie Bowden; Lisa Valletta; Mark Herb; Rose Tominovich; Robert W Tuman
Synthesis and anti-angiogenic activity of 6-(1,2,4-thiadiazol-5-yl)-3-amino pyridazine derivatives.
Bioorganic & medicinal chemistry letters 2002;12(4):589-91.