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Frank Boschelli

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Richard J Murrills; Jane Owens; Dharmesh Patel; Vikki Spaulding; Yanong D Wang; Yuchen Bai; Frederick J Bex; Diane H Boschelli; Frank Boschelli; Laura Carter; Veronica Diesl; Max Follettie; Shoichi Fukayama; Jennifer M Golas; Jason Jussif; Yogendra P Kharode; Barry Komm; Giovan Lane; X Jian Li; Yao-Bin Liu; Susan Lockhead; Jeanne J Matteo; John C McKew; Colleen Milligan; Peter V N Bodine
Osteogenic effects of a potent Src-over-Abl-selective kinase inhibitor in the mouse.
Christoph W Zapf; Jonathan D Bloom; Frank Boschelli; Russell G Dushin; Jennifer M Golas; Mark Johnson; Zhong Li; Hao Liu; Judy Lucas; Antonia Nikitenko; Thomas Nittoli; Andrea Olland; Mercy Otteng; Erik Vogan; Jeremy I Levin
Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model.
Shi Liang; Kevin Pong; Cathleen Gonzales; Yi Chen; Huai-Ping Ling; Robert J Mark; Frank Boschelli; Diane H Boschelli; Fei Ye; Ana Carolina Barrios Sosa; Tarek S Mansour; Philip Frost; Andrew Wood; Menelas Pangalos; Margaret M Zaleska
Neuroprotective profile of novel SRC kinase inhibitors in rodent models of cerebral ischemia.

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All Publications

2012: Richard J Murrills; Jane Owens; Dharmesh Patel; Vikki Spaulding; Yanong D Wang; Yuchen Bai; Frederick J Bex; Diane H Boschelli; Frank Boschelli; Laura Carter; Veronica Diesl; Max Follettie; Shoichi Fukayama; Jennifer M Golas; Jason Jussif; Yogendra P Kharode; Barry Komm; Giovan Lane; X Jian Li; Yao-Bin Liu; Susan Lockhead; Jeanne J Matteo; John C McKew; Colleen Milligan; Peter V N Bodine
Osteogenic effects of a potent Src-over-Abl-selective kinase inhibitor in the mouse.
The Journal of pharmacology and experimental therapeutics 2012;340(3):676-87.
2011: Christoph W Zapf; Jonathan D Bloom; Frank Boschelli; Russell G Dushin; Jennifer M Golas; Mark Johnson; Zhong Li; Hao Liu; Judy Lucas; Antonia Nikitenko; Thomas Nittoli; Andrea Olland; Mercy Otteng; Erik Vogan; Jeremy I Levin
Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model.
Bioorganic & medicinal chemistry letters 2011;21(15):4602-7.
2009: Shi Liang; Kevin Pong; Cathleen Gonzales; Yi Chen; Huai-Ping Ling; Robert J Mark; Frank Boschelli; Diane H Boschelli; Fei Ye; Ana Carolina Barrios Sosa; Tarek S Mansour; Philip Frost; Andrew Wood; Menelas Pangalos; Margaret M Zaleska
Neuroprotective profile of novel SRC kinase inhibitors in rodent models of cerebral ischemia.
The Journal of pharmacology and experimental therapeutics 2009;331(3):827-35.
2009: Nan Zhang; Biqi Wu; Diane H Boschelli; Jennifer M Golas; Frank Boschelli
4-Anilino-7-pyridyl-3-quinolinecarbonitriles as Src kinase inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(17):5071-4.
2009: Wells A Messersmith; RAJESH KUMAR NV; Aik Choon Tan; Xiao Fei Wang; Veronica Diesl; Sung E Choe; Max Follettie; Christina Coughlin; Frank Boschelli; Elena Garcia-Garcia; Fernando Lopez-Rios; Antonio Jimeno; Manuel Hidalgo
Efficacy and pharmacodynamic effects of bosutinib (SKI-606), a Src/Abl inhibitor, in freshly generated human pancreas cancer xenografts.
Molecular cancer therapeutics 2009;8(6):1484-93.
2009: Luca Mologni; Loredana Cleris; Vera Magistroni; Rocco Piazza; Frank Boschelli; Franca Formelli; Carlo Gambacorti-Passerini
Valproic acid enhances bosutinib cytotoxicity in colon cancer cells.
International journal of cancer. Journal international du cancer 2009;124(8):1990-6.
2009: Sara Redaelli; Rocco Piazza; Roberta Rostagno; Vera Magistroni; Pietro Perini; Manuela Marega; Carlo Gambacorti-Passerini; Frank Boschelli
Activity of bosutinib, dasatinib, and nilotinib against 18 imatinib-resistant BCR/ABL mutants.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(3):469-71.
2009: Lori M Miller; Scott C Mayer; Dan M Berger; Diane H Boschelli; Frank Boschelli; Li Di; Xuemei Du; Minu Dutia; Middleton B Floyd; Mark Johnson; Cynthia Hess Kenny; Girija Krishnamurthy; Franklin Moy; Susan Petusky; Diane Tkach; Nancy Torres; Biqi Wu; Weixin Xu
Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment.
Bioorganic & medicinal chemistry letters 2009;19(1):62-6.
2008: Scott C Mayer; Annette L Banker; Frank Boschelli; Li Di; Mark Johnson; Cynthia Hess Kenny; Girija Krishnamurthy; Kristina Kutterer; Franklin Moy; Susan Petusky; Malini Ravi; Diane Tkach; Hwei-Ru Tsou; Weixin Xu
Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment.
Bioorganic & medicinal chemistry letters 2008;18(12):3641-5.
2008: Yukiyasu Ozawa; Ann H Williams; Myka L Estes; Norimasa Matsushita; Frank Boschelli; Richard Jove; Alan F List
Src family kinases promote AML cell survival through activation of signal transducers and activators of transcription (STAT).
Leukemia research 2008;32(6):893-903.
2008: Adina Vultur; Ralf Buettner; Claudia Kowolik; Wei Liang; David Smith; Frank Boschelli; Richard Jove
SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells.
Molecular cancer therapeutics 2008;7(5):1185-94.
2008: Ariamala Gopalsamy; Mengxiao Shi; Jennifer M Golas; Erik Vogan; Jaison Jacob; Mark Johnson; Frederick Lee; Ramaswamy Nilakantan; Roseann Petersen; Kristine Svenson; Rajiv Chopra; May S Tam; Yingxia Wen; John W Ellingboe; Kim Arndt; Frank Boschelli
Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.
Journal of medicinal chemistry 2008;51(3):373-5.
2008: Diane H Boschelli; Biqi Wu; Fei Ye; Haris Durutlic; Jennifer M Golas; Judy Lucas; Frank Boschelli
Facile preparation of new 4-phenylamino-3-quinolinecarbonitrile Src kinase inhibitors via 7-fluoro intermediates: identification of potent 7-amino analogs.
Bioorganic & medicinal chemistry 2008;16(1):405-12.
2007: Diane H Boschelli; Ana Carolina Barrios Sosa; Jennifer M Golas; Frank Boschelli
Inhibition of Src kinase activity by 7-ethynyl-4-phenylamino-3-quinolinecarbonitriles: identification of SKS-927.
Bioorganic & medicinal chemistry letters 2007;17(5):1358-61.
2006: Diane H Boschelli; Biqi Wu; Fei Ye; Yan Wang; Jennifer M Golas; Judy Lucas; Frank Boschelli
Synthesis and Src kinase inhibitory activity of a series of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-furyl-3-quinolinecarbonitriles.
Journal of medicinal chemistry 2006;49(26):7868-76.
2006: Biqi Wu; Ana Carolina Barrios Sosa; Diane H Boschelli; Frank Boschelli; Erick E Honores; Jennifer M Golas; Dennis W Powell; Yanong D Wang
7-(aryl/heteroaryl-2-ylethynyl)-4-phenylamino-3-quinolinecarbonitriles as new Src kinase inhibitors: addition of water solubilizing groups.
Bioorganic & medicinal chemistry letters 2006;16(15):3993-7.
2005: Diane H Boschelli; Biqi Wu; Ana Carolina Barrios Sosa; Joan J Chen; Jennifer M Golas; Frank Boschelli
Inhibition of Src kinase activity by 7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-heteroaryl-thieno[3,2-b]pyridine-6-carbonitriles.
Bioorganic & medicinal chemistry letters 2005;15(21):4681-4.
2005: Dan M Berger; Minu Dutia; Gary Birnberg; Dennis Powell; Diane H Boschelli; Yanong D Wang; Malini Ravi; Deanna Yaczko; Jennifer M Golas; Judy Lucas; Frank Boschelli
4-Anilino-7,8-dialkoxybenzo[g]quinoline-3-carbonitriles as potent Src kinase inhibitors.
Journal of medicinal chemistry 2005;48(19):5909-20.
2005: Jennifer M Golas; Judy Lucas; Carlo Etienne; Jennifer M Golas; Carolyn Discafani; Latha Sridharan; Erwin R Boghaert; Kim Arndt; Fei Ye; Diane H Boschelli; Fangbiao Li; Craig Titsch; Christine Huselton; Inder Chaudhary; Frank Boschelli
SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models.
Cancer research 2005;65(12):5358-64.
2005: Diane H Boschelli; Biqi Wu; Ana Carolina Barrios Sosa; Haris Durutlic; Joan J Chen; Yan Wang; Jennifer M Golas; Judy Lucas; Frank Boschelli
Synthesis and Src kinase inhibitory activity of 2-phenyl- and 2-thienyl-7-phenylaminothieno[3,2-b]pyridine-6-carbonitriles.
Journal of medicinal chemistry 2005;48(11):3891-902.
2004: Diane H Boschelli; Biqi Wu; Ana Carolina Barrios Sosa; Haris Durutlic; Fei Ye; Yuri Raifeld; Jennifer M Golas; Frank Boschelli
Identification of 7-phenylaminothieno- [3,2-b]pyridine-6-carbonitriles as a new class of Src kinase inhibitors.
Journal of medicinal chemistry 2004;47(27):6666-8.
2004: Ana Carolina Barrios Sosa; Diane H Boschelli; Fei Ye; Jennifer M Golas; Frank Boschelli
Synthesis and inhibition of Src kinase activity by 7-ethenyl and 7-ethynyl-4-anilino-3-quinolinecarbonitriles.
Bioorganic & medicinal chemistry letters 2004;14(9):2155-8.
2004: Diane H Boschelli; Yanong D Wang; Steve Johnson; Biqi Wu; Fei Ye; Ana Carolina Barrios Sosa; Jennifer M Golas; Frank Boschelli
7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as dual inhibitors of Src and Abl kinases.
Journal of medicinal chemistry 2004;47(7):1599-601.
2003: Diane H Boschelli; Fei Ye; Biqi Wu; Yanong D Wang; Ana Carolina Barrios Sosa; Deanna Yaczko; Dennis Powell; Jennifer M Golas; Judy Lucas; Frank Boschelli
Investigation of the effect of varying the 4-anilino and 7-alkoxy groups of 3-quinolinecarbonitriles on the inhibition of Src kinase activity.
Bioorganic & medicinal chemistry letters 2003;13(21):3797-800.
2003: Diane H Boschelli; Dennis Powell; Jennifer M Golas; Frank Boschelli
Inhibition of Src kinase activity by 4-anilino-5,10-dihydro-pyrimido[4,5-b]quinolines.
Bioorganic & medicinal chemistry letters 2003;13(18):2977-80.
2003: Jennifer M Golas; Kim Arndt; Carlo Etienne; Judy Lucas; Danielle Nardin; James Gibbons; Philip Frost; Fei Ye; Diane H Boschelli; Frank Boschelli
SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice.
Cancer research 2003;63(2):375-81.
2002: Dan Berger; Minu Dutia; Dennis Powell; Allan Wissner; Frenel DeMorin; Yuri Raifeld; Jennifer Weber; Frank Boschelli
Substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles as Src kinase inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(20):2989-92.
2002: Dan Berger; Minu Dutia; Dennis Powell; Biqi Wu; Allan Wissner; Frenel DeMorin; Jennifer Weber; Frank Boschelli
8-Anilinoimidazo[4,5-g]quinoline-7-carbonitriles as Src kinase inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(19):2761-5.
2002: Diane H Boschelli; Daniel Y Wang; Fei Ye; Ayako Yamashita; Nan Zhang; Dennis Powell; Jennifer Weber; Frank Boschelli
Inhibition of Src kinase activity by 4-anilino-7-thienyl-3-quinolinecarbonitriles.
Bioorganic & medicinal chemistry letters 2002;12(15):2011-4.
2002: Nan Zhang; Biqi Wu; Allan Wissner; Dennis W Powell; Sridhar K Rabindran; Constance Kohler; Frank Boschelli
4-Anilino-3-cyanobenzo[g]quinolines as kinase inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(3):423-5.
2001: Diane H Boschelli; Fei Ye; Yanong D Wang; Minu Dutia; S L Johnson; Biqi Wu; K Miller; Dennis W Powell; Deanna Yaczko; M Young; M Tischler; Kim Arndt; Carolyn Discafani; Carlo Etienne; James Gibbons; J Grod; Judy Lucas; JM Weber; Frank Boschelli
Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity.
Journal of medicinal chemistry 2001;44(23):3965-77.
2001: Diane H Boschelli; Yanong D Wang; Fei Ye; Biqi Wu; Nan Zhang; Minu Dutia; Dennis W Powell; Allan Wissner; Kim Arndt; JM Weber; Frank Boschelli
Synthesis and Src kinase inhibitory activity of a series of 4-phenylamino-3-quinolinecarbonitriles.
Journal of medicinal chemistry 2001;44(5):822-33.
2000: Yanong D Wang; K Miller; Diane H Boschelli; Fei Ye; Biqi Wu; M Brawner Floyd; Dennis W Powell; Allan Wissner; JM Weber; Frank Boschelli
Inhibitors of src tyrosine kinase: the preparation and structure-activity relationship of 4-anilino-3-cyanoquinolines and 4-anilinoquinazolines.
Bioorganic & medicinal chemistry letters 2000;10(21):2477-80.