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York Tomita

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Haiying Sun; Zaneta Nikolovska-Coleska; Jianfeng Lu; Jennifer Meagher; Chao-Yie Yang; Su Qiu; York Tomita; Yumi Ueda; Sheng Jiang; Krzysztof Krajewski; Peter P Roller; Jeanne A Stuckey; Shaomeng Wang
Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP.
Guoping Wang; Zaneta Nikolovska-Coleska; Chao-Yie Yang; Renxiao Wang; Guozhi Tang; Jie Guo; Sanjeev Shangary; Su Qiu; Wei Gao; Dajun Yang; Jennifer Meagher; Jeanne A Stuckey; Krzysztof Krajewski; Sheng Jiang; Peter P Roller; Hatice Ozel Abaan; York Tomita; Shaomeng Wang
Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.
Ke Ding; Yipin Lu; Zaneta Nikolovska-Coleska; Su Qiu; Yousong Ding; Wei Gao; Jeanne A Stuckey; Krzysztof Krajewski; Peter P Roller; York Tomita; Damon Parrish; Jeffrey Deschamps; Shaomeng Wang
Structure-based design of potent non-peptide MDM2 inhibitors.

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All Publications

2007: Haiying Sun; Zaneta Nikolovska-Coleska; Jianfeng Lu; Jennifer Meagher; Chao-Yie Yang; Su Qiu; York Tomita; Yumi Ueda; Sheng Jiang; Krzysztof Krajewski; Peter P Roller; Jeanne A Stuckey; Shaomeng Wang
Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP.
Journal of the American Chemical Society 2007;129(49):15279-94.
2006: Guoping Wang; Zaneta Nikolovska-Coleska; Chao-Yie Yang; Renxiao Wang; Guozhi Tang; Jie Guo; Sanjeev Shangary; Su Qiu; Wei Gao; Dajun Yang; Jennifer Meagher; Jeanne A Stuckey; Krzysztof Krajewski; Sheng Jiang; Peter P Roller; Hatice Ozel Abaan; York Tomita; Shaomeng Wang
Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.
Journal of medicinal chemistry 2006;49(21):6139-42.
2005: Ke Ding; Yipin Lu; Zaneta Nikolovska-Coleska; Su Qiu; Yousong Ding; Wei Gao; Jeanne A Stuckey; Krzysztof Krajewski; Peter P Roller; York Tomita; Damon Parrish; Jeffrey Deschamps; Shaomeng Wang
Structure-based design of potent non-peptide MDM2 inhibitors.
Journal of the American Chemical Society 2005;127(29):10130-1.
2005: Haiying Sun; Zaneta Nikolovska-Coleska; Jianyong Chen; Chao-Yie Yang; York Tomita; Hongguang Pan; Yoshiko Yoshioka; Krzysztof Krajewski; Peter P Roller; Shaomeng Wang
Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics.
Bioorganic & medicinal chemistry letters 2005;15(3):793-7.
2004: Haiying Sun; Zaneta Nikolovska-Coleska; Chao-Yie Yang; Liang Xu; Meilan Liu; York Tomita; Hongguang Pan; Yoshiko Yoshioka; Krzysztof Krajewski; Peter P Roller; Shaomeng Wang
Structure-based design of potent, conformationally constrained Smac mimetics.
Journal of the American Chemical Society 2004;126(51):16686-7.
2004: Zaneta Nikolovska-Coleska; Renxiao Wang; Xueliang Fang; Hongguang Pan; York Tomita; Peng Li; Peter P Roller; Krzysztof Krajewski; Naoyuki G Saito; Jeanne A Stuckey; Shaomeng Wang
Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization.
Analytical biochemistry 2004;332(2):261-73.
2004: Haiying Sun; Zaneta Nikolovska-Coleska; Chao-Yie Yang; Liang Xu; York Tomita; Krzysztof Krajewski; Peter P Roller; Shaomeng Wang
Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site.
Journal of medicinal chemistry 2004;47(17):4147-50.
2004: Zaneta Nikolovska-Coleska; Liang Xu; Zengjian Hu; York Tomita; Peng Li; Peter P Roller; Renxiao Wang; Xueliang Fang; Ribo Guo; Manchao Zhang; Marc Lippman; Dajun Yang; Shaomeng Wang
Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database.
Journal of medicinal chemistry 2004;47(10):2430-40.