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Kazuma Tomizuka

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Yasuhiro Kazuki; Kaoru Kobayashi; Kinya Kubo; Yoshimi Kuroiwa; Sumio Ohtsuki; Takeshi Oshima; Satoshi Abe; Sasitorn Aueviriyavit; Kan Chiba; Hidetoshi Hoshiya; Naoyo Kajitani; Hiroki Kawakami; Naoto Senda; S Takehara; Masato Takiguchi; Tetsuya Terasaki; Kazuma Tomizuka; Yasuko Tsukazaki; Mitsuo Oshimura
Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans.
Minoru Kakeda; Yasuhiro Kazuki; Anri Masuya; Hiroki Matsuno; Keiko Nagata; Satoshi Nishikawa; Akiyo Okazaki; Mitsuhiko Osaki; Kanako Osawa; Mitsuo Oshimura; Akiko Sano; Shingo Shitara; Toshihiro Hata; Masaharu Hiratsuka; Shun Wako; Kazuma Tomizuka
A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells.
Yuri Shibasaki; Nobuaki Etoh; Michiko Hayasaka; Moto-o Takahashi; Makoto Kakitani; Takeyoshi Yamashita; Kazuma Tomizuka; Kazunori Hanaoka
Targeted deletion of the tybe IIb Na(+)-dependent Pi-co-transporter, NaPi-IIb, results in early embryonic lethality.

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All Publications

2013: Yasuhiro Kazuki; Kaoru Kobayashi; Kinya Kubo; Yoshimi Kuroiwa; Sumio Ohtsuki; Takeshi Oshima; Satoshi Abe; Sasitorn Aueviriyavit; Kan Chiba; Hidetoshi Hoshiya; Naoyo Kajitani; Hiroki Kawakami; Naoto Senda; S Takehara; Masato Takiguchi; Tetsuya Terasaki; Kazuma Tomizuka; Yasuko Tsukazaki; Mitsuo Oshimura
Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans.
Human molecular genetics 2013;22(3):578-92.
2011: Minoru Kakeda; Yasuhiro Kazuki; Anri Masuya; Hiroki Matsuno; Keiko Nagata; Satoshi Nishikawa; Akiyo Okazaki; Mitsuhiko Osaki; Kanako Osawa; Mitsuo Oshimura; Akiko Sano; Shingo Shitara; Toshihiro Hata; Masaharu Hiratsuka; Shun Wako; Kazuma Tomizuka
A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells.
Biochemical and biophysical research communications 2011;415(3):439-44.
2009: Yuri Shibasaki; Nobuaki Etoh; Michiko Hayasaka; Moto-o Takahashi; Makoto Kakitani; Takeyoshi Yamashita; Kazuma Tomizuka; Kazunori Hanaoka
Targeted deletion of the tybe IIb Na(+)-dependent Pi-co-transporter, NaPi-IIb, results in early embryonic lethality.
Biochemical and biophysical research communications 2009;381(4):482-6.
2008: Shingo Shitara; Minoru Kakeda; Keiko Nagata; Masaharu Hiratsuka; Akiko Sano; Kanako Osawa; Akiyo Okazaki; Motonobu Katoh; Yasuhiro Kazuki; Mitsuo Oshimura; Kazuma Tomizuka
Telomerase-mediated life-span extension of human primary fibroblasts by human artificial chromosome (HAC) vector.
Biochemical and biophysical research communications 2008;369(3):807-11.
2006: Kyung-Ah Kim; Jingsong Zhao; Susan Andarmani; Makoto Kakitani; Takeshi Oshima; Minke E Binnerts; Arie Abo; Kazuma Tomizuka; Walter D Funk
R-Spondin proteins: a novel link to beta-catenin activation.
Cell cycle (Georgetown, Tex.) 2006;5(1):23-6.
2005: Ayano Yanagisawa; Chisato Endo; Katsuya Okawa; Shingo Shitara; Hiroyuki Kugoh; Makoto Kakitani; Mitsuo Oshimura; Kazuma Tomizuka
Generation of chromosome-specific monoclonal antibodies using in vitro-differentiated transchromosomic mouse embryonic stem cells.
Stem cells (Dayton, Ohio) 2005;23(10):1479-88.
2005: Takashi Shimada; Yuji Yamazaki; Motoo Takahashi; Hisashi Hasegawa; Itaru Urakawa; Takeshi Oshima; Kaori Ono; Makoto Kakitani; Kazuma Tomizuka; Toshiro Fujita; Seiji Fukumoto; Takeyoshi Yamashita
Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism.
American journal of physiology. Renal physiology 2005;289(5):F1088-95.
2005: Kyung-Ah Kim; Makoto Kakitani; Jingsong Zhao; Takeshi Oshima; Tom Tang; Minke E Binnerts; Yi Liu; Bryan Boyle; Emily Park; Peter Emtage; Walter D Funk; Kazuma Tomizuka
Mitogenic influence of human R-spondin1 on the intestinal epithelium.
Science (New York, N.Y.) 2005;309(5738):1256-9.
2005: Takeo Kitamoto; Keikichi Takahashi; Hiroaki Takimoto; Kazuma Tomizuka; Michiko Hayasaka; Takeshi Tabira; Kazunori Hanaoka
Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice.
Biochemical and biophysical research communications 2005;331(4):1154-62.
2005: Minoru Kakeda; M Hiratsuka; K Nagata; Yoshimi Kuroiwa; Makoto Kakitani; M Katoh; Mitsuo Oshimura; Kazuma Tomizuka
Human artificial chromosome (HAC) vector provides long-term therapeutic transgene expression in normal human primary fibroblasts.
Gene therapy 2005;12(10):852-6.
2005: Hiroe Kudoh; Haruko Ikeda; Makoto Kakitani; Akiko Ueda; Michiko Hayasaka; Kazuma Tomizuka; Kazunori Hanaoka
A new model mouse for Duchenne muscular dystrophy produced by 2.4 Mb deletion of dystrophin gene using Cre-loxP recombination system.
Biochemical and biophysical research communications 2005;328(2):507-16.
2005: Makoto Kakitani; Takeshi Oshima; Kaori Horikoshi; Tetsuo Yoshitome; Akiko Ueda; Miwa Kajikawa; Yumi Iba; Yoshinao Ozone; Yuki Ijima; Tohko Yoshino; Mikiko Itoh; Sachiko Seki; Ayako Aoki; Toshie Ishihara; Michiyo Shionoya; Utako Makino; Rina Kitada; Atsuko Ohguma; Takami Ohta; Yoshimasa Yoshida; Hiroe Kudoh; Kazunori Hanaoka; Kazunori Sibuya; Isao Ishida; Minoru Kakeda; Mikio Yagi; Takashi Yoneya; Kazuma Tomizuka
A novel transgenic chimaeric mouse system for the rapid functional evaluation of genes encoding secreted proteins.
Nucleic acids research 2005;33(9):e85.
2004: Yoshimi Kuroiwa; Poothappillai Kasinathan; Hiroaki Matsushita; Janaki Sathiyaselan; Eddie J Sullivan; Makoto Kakitani; Kazuma Tomizuka; Isao Ishida; James M Robl
Sequential targeting of the genes encoding immunoglobulin-mu and prion protein in cattle.
Nature genetics 2004;36(7):775-80.
2004: Yasuhiro Kazuki; Motoshi Kimura; Ryuichi Nishigaki; Yoshiteru Kai; Satoshi Abe; Chiga Okita; Yasuaki Shirayoshi; Thomas C Schulz; Kazuma Tomizuka; Kazunori Hanaoka; Toshiaki Inoue; Mitsuo Oshimura
Human chromosome 21q22.2-qter carries a gene(s) responsible for downregulation of mlc2a and PEBP in Down syndrome model mice.
Biochemical and biophysical research communications 2004;317(2):491-9.
2004: Takashi Shimada; Makoto Kakitani; Yuji Yamazaki; Hisashi Hasegawa; Yasuhiro Takeuchi; Toshiro Fujita; Seiji Fukumoto; Kazuma Tomizuka; Takeyoshi Yamashita
Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism.
The Journal of clinical investigation 2004;113(4):561-8.
2004: E Mori; M Thomas; K Motoki; K Nakazawa; Tomoyuki Tahara; Kazuma Tomizuka; Isao Ishida; Shiro Kataoka
Human normal hepatocytes are susceptible to apoptosis signal mediated by both TRAIL-R1 and TRAIL-R2.
Cell death and differentiation 2004;11(2):203-7.
2004: Yoshimi Kuroiwa; Kazuma Tomizuka; Isao Ishida
Use of natural and artificial chromosome vectors for animal transgenesis.
Methods in molecular biology (Clifton, N.J.) 2004;240():207-25.
2003: James M Robl; Poothappillai Kasinathan; Eddie Sullivan; Yoshimi Kuroiwa; Kazuma Tomizuka; Isao Ishida
Artificial chromosome vectors and expression of complex proteins in transgenic animals.
Theriogenology 2003;59(1):107-13.
2002: Yoshimi Kuroiwa; Poothappillai Kasinathan; Yoon J Choi; Rizwan C. Naeem; Kazuma Tomizuka; Eddie J Sullivan; Jason Glenn Knott; Anae Duteau; Richard A Goldsby; Barbara A Osborne; Isao Ishida; James M Robl
Cloned transchromosomic calves producing human immunoglobulin.
Nature biotechnology 2002;20(9):889-94.
2002: Yoshimi Kuroiwa; Hitoshi Yoshida; T Ohshima; Tokuyuki Shinohara; Atsuko Ohguma; Yasuhiro Kazuki; Mitsuo Oshimura; Isao Ishida; Kazuma Tomizuka
The use of chromosome-based vectors for animal transgenesis.
Gene therapy 2002;9(11):708-12.
2002: Isao Ishida; Kazuma Tomizuka; Hitoshi Yoshida; Yoshimi Kuroiwa
TransChromo Mouse.
Biotechnology & genetic engineering reviews 2002;19():73-82.
2002: Isao Ishida; Kazuma Tomizuka; Hitoshi Yoshida; Tomoyuki Tahara; Nobuaki Takahashi; Atsuko Ohguma; Sonoko Tanaka; Misako Umehashi; Hiroaki Maeda; Chikateru Nozaki; Ed Halk; Nils Lonberg
Production of human monoclonal and polyclonal antibodies in TransChromo animals.
Cloning and stem cells 2002;4(1):91-102.
2001: Tokuyuki Shinohara; Kazuma Tomizuka; S Miyabara; S Takehara; Yasuhiro Kazuki; J Inoue; Motonobu Katoh; H Nakane; Akihiro Iino; Atsuko Ohguma; S Ikegami; K Inokuchi; Isao Ishida; Roger H Reeves; Mitsuo Oshimura
Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down's syndrome.
Human molecular genetics 2001;10(11):1163-75.
2001: Yasuhiro Kazuki; Tokuyuki Shinohara; Kazuma Tomizuka; Motonobu Katoh; Atsuko Ohguma; Isao Ishida; Mitsuo Oshimura
Germline transmission of a transferred human chromosome 21 fragment in transchromosomal mice.
Journal of human genetics 2001;46(10):600-3.
2000: Yoshimi Kuroiwa; Kazuma Tomizuka; Tokuyuki Shinohara; Yasuhiro Kazuki; Hitoshi Yoshida; Atsuko Ohguma; T Yamamoto; S Tanaka; Mitsuo Oshimura; Isao Ishida
Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts.
Nature biotechnology 2000;18(10):1086-90.
2000: Y Tamai; K Tanaka; N Umemoto; Kazuma Tomizuka; Y Kaneko
Diversity of the HO gene encoding an endonuclease for mating-type conversion in the bottom fermenting yeast Saccharomyces pastorianus.
Yeast (Chichester, England) 2000;16(14):1335-43.
2000: Kazuma Tomizuka; Tokuyuki Shinohara; Hitoshi Yoshida; H Uejima; Atsuko Ohguma; S Tanaka; K Sato; Mitsuo Oshimura; Isao Ishida
Double trans-chromosomic mice: maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):722-7.
2000: Tokuyuki Shinohara; Kazuma Tomizuka; S Takehara; K Yamauchi; Motonobu Katoh; Atsuko Ohguma; Isao Ishida; Mitsuo Oshimura
Stability of transferred human chromosome fragments in cultured cells and in mice.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2000;8(8):713-25.
1998: Yoshimi Kuroiwa; T Shinohara; T Notsu; Kazuma Tomizuka; Hitoshi Yoshida; S Takeda; Mitsuo Oshimura; Isao Ishida
Efficient modification of a human chromosome by telomere-directed truncation in high homologous recombination-proficient chicken DT40 cells.
Nucleic acids research 1998;26(14):3447-8.
1998: Isao Ishida; H Yoshida; Kazuma Tomizuka
Production of a diverse repertoire of human antibodies in genetically engineered mice.
Microbiology and immunology 1998;42(3):143-50.
1997: Kazuma Tomizuka; Hitoshi Yoshida; H Uejima; Hiroyuki Kugoh; K Sato; Atsuko Ohguma; Michiko Hayasaka; K Hanaoka; Mitsuo Oshimura; Isao Ishida
Functional expression and germline transmission of a human chromosome fragment in chimaeric mice.
Nature genetics 1997;16(2):133-43.