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David Tomlinson

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Elizabeth J Pawson; Beatriz Duran-Jimenez; Richard Surosky; Heather E Brooke; S Kaye Spratt; David R Tomlinson; Natalie J Gardiner
Engineered zinc finger protein-mediated VEGF-a activation restores deficient VEGF-a in sensory neurons in experimental diabetes.
David R Tomlinson; Natalie J Gardiner
Diabetic neuropathies: components of etiology.
David R Tomlinson; Natalie J Gardiner
Glucose neurotoxicity.

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2010: Elizabeth J Pawson; Beatriz Duran-Jimenez; Richard Surosky; Heather E Brooke; S Kaye Spratt; David R Tomlinson; Natalie J Gardiner
Engineered zinc finger protein-mediated VEGF-a activation restores deficient VEGF-a in sensory neurons in experimental diabetes.
Diabetes 2010;59(2):509-18.
2008: David R Tomlinson; Natalie J Gardiner
Diabetic neuropathies: components of etiology.
Journal of the peripheral nervous system : JPNS 2008;13(2):112-21.
2008: David R Tomlinson; Natalie J Gardiner
Glucose neurotoxicity.
Nature reviews. Neuroscience 2008;9(1):36-45.
2008: Eugenia Karamoysoyli; Rebecca C Burnand; David R Tomlinson; Natalie J Gardiner
Neuritin mediates nerve growth factor-induced axonal regeneration and is deficient in experimental diabetic neuropathy.
Diabetes 2008;57(1):181-9.
2007: Natalie J Gardiner; Sarah Moffatt; Paul Fernyhough; Martin J Humphries; Charles H Streuli; David R Tomlinson
Preconditioning injury-induced neurite outgrowth of adult rat sensory neurons on fibronectin is mediated by mobilisation of axonal alpha5 integrin.
Molecular and cellular neurosciences 2007;35(2):249-60.
2006: Sally A Price; Natalie J Gardiner; Beatriz Duran-Jimenez; Leo A H Zeef; Irina G Obrosova; David R Tomlinson
Thioredoxin interacting protein is increased in sensory neurons in experimental diabetes.
Brain research 2006;1116(1):206-14.
2006: Sally A Price; Leo A H Zeef; Leanne Wardleworth; Andrew Hayes; David R Tomlinson
Identification of changes in gene expression in dorsal root ganglia in diabetic neuropathy: correlation with functional deficits.
Journal of neuropathology and experimental neurology 2006;65(7):722-32.
2006: Sally A Price; Carolyn Dent; Beatriz Duran-Jimenez; Yuxin Liang; Lei Zhang; Edward J Rebar; Casey C Case; Philip D Gregory; Tyler J Martin; S Kaye Spratt; David R Tomlinson
Gene transfer of an engineered transcription factor promoting expression of VEGF-A protects against experimental diabetic neuropathy.
Diabetes 2006;55(6):1847-54.
2006: Alicia Middlemas; Sithiporn Agthong; David R Tomlinson
Phosphorylation of c-Jun N-terminal kinase (JNK) in sensory neurones of diabetic rats, with possible effects on nerve conduction and neuropathic pain: prevention with an aldose reductase inhibitor.
Diabetologia 2006;49(3):580-7.
2005: Natalie J Gardiner; Paul Fernyhough; David R Tomlinson; Ulrike Mayer; Helga von der Mark; Charles H Streuli
Alpha7 integrin mediates neurite outgrowth of distinct populations of adult sensory neurons.
Molecular and cellular neurosciences 2005;28(2):229-40.
2004: Rebecca C Burnand; Sally A Price; M McElhaney; D Barker; David R Tomlinson
Expression of axotomy-inducible and apoptosis-related genes in sensory nerves of rats with experimental diabetes.
Brain research. Molecular brain research 2004;132(2):235-40.
2004: Lucy Chilton; Alicia Middlemas; Natalie J Gardiner; David R Tomlinson
The p75 neurotrophin receptor appears in plasma in diabetic rats-characterisation of a potential early test for neuropathy.
Diabetologia 2004;47(11):1924-30.
2004: Sally A Price; Sithiporn Agthong; Alicia Middlemas; David R Tomlinson
Mitogen-activated protein kinase p38 mediates reduced nerve conduction velocity in experimental diabetic neuropathy: interactions with aldose reductase.
Diabetes 2004;53(7):1851-6.
2003: Sally A Price; Luke Hounsom; Tertia Purves-Tyson; Paul Fernyhough; David R Tomlinson
Activation of JNK in sensory neurons protects against sensory neuron cell death in diabetes and on exposure to glucose/oxidative stress in vitro.
Annals of the New York Academy of Sciences 2003;1010():95-9.
2003: Jean-Dominique Delcroix; Jyoti Patel; Sharon Averill; David R Tomlinson; John V Priestley; Paul Fernyhough
Peripheral axon crush elevates transport of p75NTR in the central projection of sensory neurones of rats.
Neuroscience letters 2003;351(3):181-5.
2003: Nicola M Sayers; Lisa J Beswick; Alicia Middlemas; Nigel A Calcutt; Andrew P Mizisin; David R Tomlinson; Paul Fernyhough
Neurotrophin-3 prevents the proximal accumulation of neurofilament proteins in sensory neurons of streptozocin-induced diabetic rats.
Diabetes 2003;52(9):2372-80.
2003: Tze-Jen Huang; Sally A Price; Lucy Chilton; Nigel A Calcutt; David R Tomlinson; Alexei Verkhratsky; Paul Fernyhough
Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia.
Diabetes 2003;52(8):2129-36.
2003: Alicia Middlemas; Jean-Dominique Delcroix; Nicola M Sayers; David R Tomlinson; Paul Fernyhough
Enhanced activation of axonally transported stress-activated protein kinases in peripheral nerve in diabetic neuropathy is prevented by neurotrophin-3.
Brain : a journal of neurology 2003;126(Pt 7):1671-82.
2003: Nigel A Calcutt; Karen L Allendoerfer; Andrew P Mizisin; Alicia Middlemas; Jason D Freshwater; Monica Burgers; Rigel Ranciato; Jean-Dominique Delcroix; Frederick R Taylor; Renee Shapiro; Kathy Strauch; Henryk Dudek; Thomas Engber; Alphonse Galdes; Lee L Rubin; David R Tomlinson
Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy.
The Journal of clinical investigation 2003;111(4):507-14.
2002: Tertia Purves-Tyson; David R Tomlinson
Diminished transcription factor survival signals in dorsal root ganglia in rats with streptozotocin-induced diabetes.
Annals of the New York Academy of Sciences 2002;973():472-6.
2002: Sithiporn Agthong; David R Tomlinson
Inhibition of p38 MAP kinase corrects biochemical and neurological deficits in experimental diabetic neuropathy.
Annals of the New York Academy of Sciences 2002;973():359-62.
2002: Tertia Purves-Tyson; David R Tomlinson
Are mitogen-activated protein kinases glucose transducers for diabetic neuropathies?
International review of neurobiology 2002;50():83-114.
2001: Tertia Purves-Tyson; Alicia Middlemas; Sithiporn Agthong; Edward B Jude; Andrew J M Boulton; Paul Fernyhough; David R Tomlinson
A role for mitogen-activated protein kinases in the etiology of diabetic neuropathy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(13):2508-14.
2001: PA Vo; David R Tomlinson
Effects of nerve growth factor on expression of GAP-43 in right atria after sympathectomy in diabetic rats.
Diabetes, obesity & metabolism 2001;3(5):350-9.
2001: L Eckersley; A D Ansselin; David R Tomlinson
Effects of experimental diabetes on axonal and Schwann cell changes in sciatic nerve isografts.
Brain research. Molecular brain research 2001;92(1-2):128-37.
2001: Sharon Averill; Jean-Dominique Delcroix; Gregory J Michael; David R Tomlinson; Paul Fernyhough; John V Priestley
Nerve growth factor modulates the activation status and fast axonal transport of ERK 1/2 in adult nociceptive neurones.
Molecular and cellular neurosciences 2001;18(2):183-96.
2001: Luke Hounsom; R Corder; J Patel; David R Tomlinson
Oxidative stress participates in the breakdown of neuronal phenotype in experimental diabetic neuropathy.
Diabetologia 2001;44(4):424-8.
2000: S Samina Riaz ; David R Tomlinson
Pharmacological modulation of nerve growth factor synthesis: a mechanistic comparison of vitamin D receptor and beta(2)-adrenoceptor agonists.
Brain research. Molecular brain research 2000;85(1-2):179-88.
2000: S Kendall; M Yeo; P Henttu; David R Tomlinson
Alternative splicing of the neurotrophin-3 gene gives rise to different transcripts in a number of human and rat tissues.
Journal of neurochemistry 2000;75(1):41-7.
2000: Robert E Schmidt; Denise A Dorsey; Kevin A Roth; Curtis A Parvin; Luke Hounsom; David R Tomlinson
Effect of streptozotocin-induced diabetes on NGF, P75(NTR) and TrkA content of prevertebral and paravertebral rat sympathetic ganglia.
Brain research 2000;867(1-2):149-56.
1999: S Riaz; M Malcangio; M Miller; David R Tomlinson
A vitamin D(3) derivative (CB1093) induces nerve growth factor and prevents neurotrophic deficits in streptozotocin-diabetic rats.
Diabetologia 1999;42(11):1308-13.
1999: David R Tomlinson
Mitogen-activated protein kinases as glucose transducers for diabetic complications.
Diabetologia 1999;42(11):1271-81.
1999: J Patel; David R Tomlinson
Nerve conduction impairment in experimental diabetes-proximodistal gradient of severity.
Muscle & nerve 1999;22(10):1403-11.
1999: Jean-Dominique Delcroix; Sharon Averill; K Fernandes; David R Tomlinson; John V Priestley; Paul Fernyhough
Axonal transport of activating transcription factor-2 is modulated by nerve growth factor in nociceptive neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(18):RC24.
1999: F Cai; W M Campana; David R Tomlinson; Paul Fernyhough
Transforming growth factor-beta1 and glial growth factor 2 reduce neurotrophin-3 mRNA expression in cultured Schwann cells via a cAMP-dependent pathway.
Brain research. Molecular brain research 1999;71(2):256-64.
1999: PA Vo; David R Tomlinson
The regeneration of peripheral noradrenergic nerves after chemical sympathectomy in diabetic rats: effects of nerve growth factor.
Experimental neurology 1999;157(1):127-34.
1999: Trine Tandrup; S Vestergaard; David R Tomlinson; LT Diemel; Johannes Jakobsen
The structural effect of systemic NGF treatment on permanently axotomised dorsal root ganglion cells in adult rats.
Journal of anatomy 1999;194 ( Pt 3)():373-9.
1999: Paul Fernyhough; A Gallagher; Sharon Averill; John V Priestley; Luke Hounsom; J Patel; David R Tomlinson
Aberrant neurofilament phosphorylation in sensory neurons of rats with diabetic neuropathy.
Diabetes 1999;48(4):881-9.
1999: F Cai; David R Tomlinson; Paul Fernyhough
Elevated expression of neurotrophin-3 mRNA in sensory nerve of streptozotocin-diabetic rats.
Neuroscience letters 1999;263(2-3):81-4.
1999: LT Diemel; F Cai; P Anand; G Warner; Peter G Kopelman; Paul Fernyhough; David R Tomlinson
Increased nerve growth factor mRNA in lateral calf skin biopsies from diabetic patients.
Diabetic medicine : a journal of the British Diabetic Association 1999;16(2):113-8.
1999: Andrew P Mizisin; Nigel A Calcutt; David R Tomlinson; A Gallagher; Paul Fernyhough
Neurotrophin-3 reverses nerve conduction velocity deficits in streptozotocin-diabetic rats.
Journal of the peripheral nervous system : JPNS 1999;4(3-4):211-21.
1999: L Mohiuddin; Jean-Dominique Delcroix; Paul Fernyhough; David R Tomlinson
Focally administered nerve growth factor suppresses molecular regenerative responses of axotomized peripheral afferents in rats.
Neuroscience 1999;91(1):265-71.
1998: M Malcangio; K Fernandes; David R Tomlinson
NMDA receptor activation modulates evoked release of substance P from rat spinal cord.
British journal of pharmacology 1998;125(8):1625-6.
1998: David R Tomlinson
Future prevention and treatment of diabetic neuropathy.
Diabetes & metabolism 1998;24 Suppl 3():79-83.
1998: Jean-Dominique Delcroix; Gregory J Michael; John V Priestley; David R Tomlinson; Paul Fernyhough
Effect of nerve growth factor treatment on p75NTR gene expression in lumbar dorsal root ganglia of streptozocin-induced diabetic rats.
Diabetes 1998;47(11):1779-85.
1998: Paul Fernyhough; W J Brewster; K Fernandes; LT Diemel; David R Tomlinson
Stimulation of nerve growth-factor and substance P expression in the iris-trigeminal axis of diabetic rats--involvement of oxidative stress and effects of aldose reductase inhibition.
Brain research 1998;802(1-2):247-53.
1998: F Cai; David R Tomlinson; Paul Fernyhough
Effect of sciatic nerve crush on local and target tissue production of neurotrophin-3 transcripts in rats.
Neuroscience letters 1998;252(1):45-8.
1998: GS Bennett; N E Garrett; LT Diemel; S D Brain; David R Tomlinson
Neurogenic cutaneous vasodilatation and plasma extravasation in diabetic rats: effect of insulin and nerve growth factor.
British journal of pharmacology 1998;124(7):1573-9.
1998: Luke Hounsom; D F Horrobin; H Tritschler; R Corder; David R Tomlinson
A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy.
Diabetologia 1998;41(7):839-43.
1998: David R Tomlinson; M Dewhurst; E J Stevens; N Omawari; A L Carrington; PA Vo
Reduced nerve blood flow in diabetic rats: relationship to nitric oxide production and inhibition of aldose reductase.
Diabetic medicine : a journal of the British Diabetic Association 1998;15(7):579-85.
1998: M Malcangio; David R Tomlinson
A pharmacologic analysis of mechanical hyperalgesia in streptozotocin/diabetic rats.
Pain 1998;76(1-2):151-7.
1998: Paul Fernyhough; LT Diemel; David R Tomlinson
Target tissue production and axonal transport of neurotrophin-3 are reduced in streptozotocin-diabetic rats.
Diabetologia 1998;41(3):300-6.
1997: L Mohiuddin; David R Tomlinson
Impaired molecular regenerative responses in sensory neurones of diabetic rats: gene expression changes in dorsal root ganglia after sciatic nerve crush.
Diabetes 1997;46(12):2057-62.
1997: Jean-Dominique Delcroix; David R Tomlinson; Paul Fernyhough
Diabetes and axotomy-induced deficits in retrograde axonal transport of nerve growth factor correlate with decreased levels of p75LNTR protein in lumbar dorsal root ganglia.
Brain research. Molecular brain research 1997;51(1-2):82-90.
1997: M Malcangio; NE Garrett; Simon C Cruwys; David R Tomlinson
Nerve growth factor- and neurotrophin-3-induced changes in nociceptive threshold and the release of substance P from the rat isolated spinal cord.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(21):8459-67.
1997: David R Tomlinson; Paul Fernyhough; LT Diemel
Role of neurotrophins in diabetic neuropathy and treatment with nerve growth factors.
Diabetes 1997;46 Suppl 2():S43-9.
1997: NE Garrett; Simon C Cruwys; Bruce L Kidd; David R Tomlinson
Effect of capsaicin on substance P and nerve growth factor in adjuvant arthritic rats.
Neuroscience letters 1997;230(1):5-8.
1997: PA Vo; David R Tomlinson
Effects of adrenergic stimulation on sciatic nerve blood flow in diabetic and control rats.
European journal of pharmacology 1997;329(2-3):147-52.
1997: M Malcangio; NE Garrett; David R Tomlinson
Nerve growth factor treatment increases stimulus-evoked release of sensory neuropeptides in the rat spinal cord.
The European journal of neuroscience 1997;9(5):1101-4.
1997: M Dewhurst; E J Stevens; David R Tomlinson
Effects of aminoguanidine and N(G)-nitro-L-arginine methyl ester on vascular responses of aortae and lungs from streptozotocin-diabetic rats.
Prostaglandins, leukotrienes, and essential fatty acids 1997;56(4):317-24.
1997: NE Garrett; M Malcangio; M Dewhurst; David R Tomlinson
alpha-Lipoic acid corrects neuropeptide deficits in diabetic rats via induction of trophic support.
Neuroscience letters 1997;222(3):191-4.
1997: C Fang; Z Jiang; David R Tomlinson
Expression of constitutive cyclo-oxygenase (COX-1) in rats with streptozotocin-induced diabetes; effects of treatment with evening primrose oil or an aldose reductase inhibitor on COX-1 mRNA levels.
Prostaglandins, leukotrienes, and essential fatty acids 1997;56(2):157-63.
1997: M Dewhurst; N Omawari; David R Tomlinson
Aminoguanidine--effects on endoneurial vasoactive nitric oxide and on motor nerve conduction velocity in control and streptozotocin-diabetic rats.
British journal of pharmacology 1997;120(4):593-8.
1997: Luke Hounsom; David R Tomlinson
Does neuropathy develop in animal models?
Clinical neuroscience (New York, N.Y.) 1997;4(6):380-9.
1996: NE Garrett; Bruce L Kidd; Simon C Cruwys; David R Tomlinson
Effect of streptozotocin-diabetes on knee joint inflammation-induced changes in substance P and nerve growth factor in the rat.
Brain research. Molecular brain research 1996;42(2):272-8.
1996: L Mohiuddin; Paul Fernyhough; David R Tomlinson
Acidic fibroblast growth factor enhances neurite outgrowth and stimulates expression of GAP-43 and T alpha 1 alpha-tubulin in cultured neurones from adult rat dorsal root ganglia.
Neuroscience letters 1996;215(2):111-4.
1996: Geert Jan Biessels; E J Stevens; S J Mahmood; W H Gispen; David R Tomlinson
Insulin partially reverses deficits in peripheral nerve blood flow and conduction in experimental diabetes.
Journal of the neurological sciences 1996;140(1-2):12-20.
1996: David R Tomlinson; Paul Fernyhough; LT Diemel; K Maeda
Deficient neurotrophic support in the aetiology of diabetic neuropathy.
Diabetic medicine : a journal of the British Diabetic Association 1996;13(7):679-81.
1996: A Belai; Nigel A Calcutt; A L Carrington; LT Diemel; David R Tomlinson; G Burnstock
Enteric neuropeptides in streptozotocin-diabetic rats; effects of insulin and aldose reductase inhibition.
Journal of the autonomic nervous system 1996;58(3):163-9.
1996: N Omawari; M Dewhurst; P Vo; S Mahmood; E Stevens; David R Tomlinson
Deficient nitric oxide responsible for reduced nerve blood flow in diabetic rats: effects of L-NAME, L-arginine, sodium nitroprusside and evening primrose oil.
British journal of pharmacology 1996;118(1):186-90.
1996: David R Tomlinson; Paul Fernyhough; LT Diemel
Neurotrophins and peripheral neuropathy.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1996;351(1338):455-62.
1995: Pam Milner; R Crowe; Paul Fernyhough; LT Diemel; David R Tomlinson; G Burnstock
Nerve growth factor treatment of adult rats selectively enhances innervation of urinogenital tract rather than vascular smooth muscle.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1995;13(5):393-401.
1995: E J Stevens; David R Tomlinson
Effects of endothelin receptor antagonism with bosentan on peripheral nerve function in experimental diabetes.
British journal of pharmacology 1995;115(2):373-9.
1995: Paul Fernyhough; LT Diemel; J Hardy; W J Brewster; L Mohiuddin; David R Tomlinson
Human recombinant nerve growth factor replaces deficient neurotrophic support in the diabetic rat.
The European journal of neuroscience 1995;7(5):1107-10.
1995: NE Garrett; Bruce L Kidd; Simon C Cruwys; David R Tomlinson
Changes in preprotachykinin mRNA expression and substance P levels in dorsal root ganglia of monoarthritic rats: comparison with changes in synovial substance P levels.
Brain research 1995;675(1-2):203-7.
1995: NE Garrett; Bruce L Kidd; Simon C Cruwys; David R Tomlinson
Streptozotocin-induced diabetes decreases substance P levels in experimental arthritis in the rat knee.
Neuroscience letters 1995;187(3):201-4.
1995: Paul Fernyhough; LT Diemel; W J Brewster; David R Tomlinson
Altered neurotrophin mRNA levels in peripheral nerve and skeletal muscle of experimentally diabetic rats.
Journal of neurochemistry 1995;64(3):1231-7.
1995: W J Brewster; Paul Fernyhough; LT Diemel; L Mohiuddin; David R Tomlinson
Changes in nerve growth factor and preprotachykinin messenger RNA levels in the iris and trigeminal ganglion in diabetic rats; effects of treatment with insulin or nerve growth factor.
Brain research. Molecular brain research 1995;29(1):131-9.
1995: L Mohiuddin; K Fernandez; David R Tomlinson; Paul Fernyhough
Nerve growth factor and neurotrophin-3 enhance neurite outgrowth and up-regulate the levels of messenger RNA for growth-associated protein GAP-43 and T alpha 1 alpha-tubulin in cultured adult rat sensory neurones.
Neuroscience letters 1995;185(1):20-3.
1995: C Karasu; M Dewhurst; E J Stevens; David R Tomlinson
Effects of anti-oxidant treatment on sciatic nerve dysfunction in streptozotocin-diabetic rats; comparison with essential fatty acids.
Diabetologia 1995;38(2):129-34.
1995: L Mohiuddin; Paul Fernyhough; David R Tomlinson
Reduced levels of mRNA encoding endoskeletal and growth-associated proteins in sensory ganglia in experimental diabetes.
Diabetes 1995;44(1):25-30.
1994: Paul Fernyhough; LT Diemel; W J Brewster; David R Tomlinson
Deficits in sciatic nerve neuropeptide content coincide with a reduction in target tissue nerve growth factor messenger RNA in streptozotocin-diabetic rats: effects of insulin treatment.
Neuroscience 1994;62(2):337-44.
1994: W J Brewster; Paul Fernyhough; LT Diemel; L Mohiuddin; David R Tomlinson
Diabetic neuropathy, nerve growth factor and other neurotrophic factors.
Trends in neurosciences 1994;17(8):321-5.
1994: David R Tomlinson; E J Stevens; LT Diemel
Aldose reductase inhibitors and their potential for the treatment of diabetic complications.
Trends in pharmacological sciences 1994;15(8):293-7.
1994: A L Carrington; C B Ettlinger; David R Tomlinson
Increased resistance to hypoxic conduction block in sciatic nerves of diabetic rats: effects of extracellular glucose concentration and of aldose reductase inhibition.
Journal of diabetes and its complications 1994;8(1):33-9.
1994: E J Stevens; A L Carrington; David R Tomlinson
Nerve ischaemia in diabetic rats: time-course of development, effect of insulin treatment plus comparison of streptozotocin and BB models.
Diabetologia 1994;37(1):43-8.
1994: LT Diemel; W J Brewster; Paul Fernyhough; David R Tomlinson
Expression of neuropeptides in experimental diabetes; effects of treatment with nerve growth factor or brain-derived neurotrophic factor.
Brain research. Molecular brain research 1994;21(1-2):171-5.
1994: W J Brewster; LT Diemel; R M Leach; David R Tomlinson
Reduced sciatic nerve substance P and calcitonin gene-related peptide in rats with short-term diabetes or central hypoxaemia co-exist with normal messenger RNA levels in the lumbar dorsal root ganglia.
Neuroscience 1994;58(2):323-30.
1993: E J Stevens; A L Carrington; David R Tomlinson
Prostacyclin release in experimental diabetes: effects of evening primrose oil.
Prostaglandins, leukotrienes, and essential fatty acids 1993;49(3):699-706.
1993: E J Stevens; G B Willars; P Lidbury; F House; David R Tomlinson
Vasoreactivity and prostacyclin release in streptozotocin-diabetic rats: effects of insulin or aldose reductase inhibition.
British journal of pharmacology 1993;109(4):980-6.
1993: A L Carrington; Nigel A Calcutt; C B Ettlinger; T Gustafsson; David R Tomlinson
Effects of treatment with myo-inositol or its 1,2,6-trisphosphate (PP56) on nerve conduction in streptozotocin-diabetes.
European journal of pharmacology 1993;237(2-3):257-63.
1993: E J Stevens; M J Lockett; A L Carrington; David R Tomlinson
Essential fatty acid treatment prevents nerve ischaemia and associated conduction anomalies in rats with experimental diabetes mellitus.
Diabetologia 1993;36(5):397-401.
1993: Paul Fernyhough; G B Willars; Ronald Lindsay; David R Tomlinson
Insulin and insulin-like growth factor I enhance regeneration in cultured adult rat sensory neurones.
Brain research 1993;607(1-2):117-24.
1993: David R Tomlinson
Aldose reductase inhibitors and the complications of diabetes mellitus.
Diabetic medicine : a journal of the British Diabetic Association 1993;10(3):214-30.
1993: J K Singh; LT Diemel; G B Willars; David R Tomlinson
The extraction and assay of substance P in the rat sciatic nerve.
Journal of neuroscience methods 1993;47(1-2):133-7.
1993: David R Tomlinson; A L Carrington; LT Diemel; C B Ettlinger; W J Smith; Paul Fernyhough
Limitations of the polyol hypothesis in the pathobiology of experimental diabetic neuropathy.
Diabetic medicine : a journal of the British Diabetic Association 1993;10 Suppl 2():27S-30S.
1992: Nigel A Calcutt; A L Carrington; C B Ettlinger; David R Tomlinson
The effect of mixed bovine brain gangliosides on hypoxic conduction block in control and streptozotocin-diabetic rats.
Journal of the neurological sciences 1992;109(1):96-101.
1992: LT Diemel; E J Stevens; G B Willars; David R Tomlinson
Depletion of substance P and calcitonin gene-related peptide in sciatic nerve of rats with experimental diabetes; effects of insulin and aldose reductase inhibition.
Neuroscience letters 1992;137(2):253-6.
1992: M J Lockett; David R Tomlinson
The effects of dietary treatment with essential fatty acids on sciatic nerve conduction and activity of the Na+/K+ pump in streptozotocin-diabetic rats.
British journal of pharmacology 1992;105(2):355-60.
1992: David R Tomlinson; G B Willars; A L Carrington
Aldose reductase inhibitors and diabetic complications.
Pharmacology & therapeutics 1992;54(2):151-94.
1991: G B Willars; Nigel A Calcutt; David R Tomlinson
Nerve conduction velocity and axonal transport of 6-phosphofructokinase activity in galactose-fed rats.
Journal of the neurological sciences 1991;104(1):46-51.
1991: A L Carrington; C B Ettlinger; Nigel A Calcutt; David R Tomlinson
Aldose reductase inhibition with imirestat-effects on impulse conduction and insulin-stimulation of Na+/K(+)-adenosine triphosphatase activity in sciatic nerves of streptozotocin-diabetic rats.
Diabetologia 1991;34(6):397-401.
1991: Nigel A Calcutt; C B Ettlinger; A L Carrington; LT Diemel; David R Tomlinson
Resistance to hypoxic conduction block in sciatic nerves of rats with streptozotocin-induced diabetes mellitus.
Journal of the neurological sciences 1991;103(1):116-23.
1991: W J Smith; LT Diemel; R M Leach; David R Tomlinson
Central hypoxaemia in rats provokes neurological defects similar to those seen in experimental diabetes mellitus: evidence for a partial role of endoneurial hypoxia in diabetic neuropathy.
Neuroscience 1991;45(2):255-9.
1990: Nigel A Calcutt; David R Tomlinson; Susmito Biswas
Coexistence of nerve conduction deficit with increased Na(+)-K(+)-ATPase activity in galactose-fed mice. Implications for polyol pathway and diabetic neuropathy.
Diabetes 1990;39(6):663-6.
1990: Nigel A Calcutt; David R Tomlinson; G B Willars; P Keen
Axonal transport of substance P-like immunoreactivity in ganglioside-treated diabetic rats.
Journal of the neurological sciences 1990;96(2-3):283-91.
1990: David R Tomlinson; G Filliatreau; B Figliomeni; R Hassig; L Di Giamberardino; G B Willars
Proteins of slow axonal transport in sciatic motoneurones of rats with streptozotocin-induced diabetes or galactosaemia.
Diabetes research and clinical practice 1990;9(1):15-21.
1989: David R Tomlinson; J P Robinson; A M Compton; P Keen
Essential fatty acid treatment--effects on nerve conduction, polyol pathway and axonal transport in streptozotocin diabetic rats.
Diabetologia 1989;32(9):655-9.
1989: G B Willars; Nigel A Calcutt; A M Compton; David R Tomlinson; P Keen
Substance P levels in peripheral nerve, skin, atrial myocardium and gastrointestinal tract of rats with long-term diabetes mellitus. Effects of aldose reductase inhibition.
Journal of the neurological sciences 1989;91(1-2):153-64.
1989: David R Tomlinson; G B Willars; Nigel A Calcutt; A M Compton; I A Macdonald; H E Clarke; P Keen
Effects of sorbinil treatment in rats with chronic streptozotocin-diabetes; changes in lens and in substance P and catecholamines in the iris.
Current eye research 1989;8(4):357-63.
1988: Nigel A Calcutt; G B Willars; David R Tomlinson
Axonal transport of choline acetyltransferase and 6-phosphofructokinase activities in genetically diabetic mice.
Muscle & nerve 1988;11(12):1206-10.
1988: Kevin C F Fone; P Dix; David R Tomlinson; G W Bennett; C A Marsden
Spinal effects of chronic intrathecal administration of the thyrotrophin-releasing hormone analogue (CG 3509) in rats.
Brain research 1988;455(1):157-61.
1988: J E Lambourne; A M Brown; Nigel A Calcutt; David R Tomlinson; G B Willars
Adenosine triphosphatase in nerves and ganglia of rats with streptozotocin-induced diabetes or galactosaemia; effects of aldose reductase inhibition.
Diabetologia 1988;31(6):379-84.
1988: Nigel A Calcutt; G B Willars; David R Tomlinson
Statil-sensitive polyol formation in nerve of galactose-fed mice.
Metabolism: clinical and experimental 1988;37(5):450-3.
1988: G B Willars; J Townsend; David R Tomlinson; A M Compton; R D Churchill
Studies on peripheral nerve and lens in long-term experimental diabetes: effects of the aldose reductase inhibitor statil.
Metabolism: clinical and experimental 1988;37(5):442-9.
1988: Nigel A Calcutt; David R Tomlinson; G B Willars
Ganglioside treatment of streptozotocin-diabetic rats prevents defective axonal transport of 6-phosphofructokinase activity.
Journal of neurochemistry 1988;50(5):1478-83.
1988: David R Tomlinson; J P Robinson; G B Willars; P Keen
Deficient axonal transport of substance P in streptozocin-induced diabetic rats. Effects of sorbinil and insulin.
Diabetes 1988;37(4):488-93.
1988: Nigel A Calcutt; David R Tomlinson; G B Willars
Ganglioside treatment of diabetic rats; effects on nerve adenosine triphosphatase activity and motor nerve conduction velocity.
Life sciences 1988;42(16):1515-20.
1987: G B Willars; J E Lambourne; David R Tomlinson
Does galactose feeding provide a valid model of consequences of exaggerated polyol-pathway flux in peripheral nerve in experimental diabetes?
Diabetes 1987;36(12):1425-31.
1987: J P Robinson; G B Willars; David R Tomlinson; P Keen
Axonal transport and tissue contents of substance P in rats with long-term streptozotocin-diabetes. Effects of the aldose reductase inhibitor 'statil'.
Brain research 1987;426(2):339-48.
1987: J P Robinson; David R Tomlinson
Fast anterograde axonal transport of choline-containing lipids in rats with experimental diabetes.
Journal of the neurological sciences 1987;81(1):93-100.
1987: J E Lambourne; David R Tomlinson; A M Brown; G B Willars
Opposite effects of diabetes and galactosaemia on adenosine triphosphatase activity in rat nervous tissue.
Diabetologia 1987;30(5):360-2.
1987: G B Willars; Nigel A Calcutt; David R Tomlinson
Reduced anterograde and retrograde accumulation of axonally transported phosphofructokinase in streptozotocin-diabetic rats: effects of insulin and the aldose reductase inhibitor 'Statil'.
Diabetologia 1987;30(4):239-43.