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Ian Tomlinson

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Single-Stranded Conformational Polymorphism

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Publications

TOP 3
Wijnen Juul T; Brohet Richard M; van Eijk Ronald; Jagmohan-Changur Shanty; Middeldorp Anneke; Tops Carli M; van Puijenbroek Mario; Ausems Margreet G E M; Gómez García Encarna; Hes Frederik J; Hoogerbrugge Nicoline; Menko Fred H; van Os Theo A M; Sijmons Rolf H; Verhoef Senno; Wagner Anja; Nagengast Fokko M; Kleibeuker Jan H; Devilee Peter; Morreau Hans; Goldgar David; Tomlinson Ian P; Houlston Richard S; van Wezel Tom; Vasen Hans F A
Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome.
Segditsas S; Rowan A J; Howarth K; Jones A; Leedham S; Wright N A; Gorman P; Chambers W; Domingo E; Roylance R R; Sawyer E J; Sieber O M; Tomlinson I P M
APC and the three-hit hypothesis.
Segditsas Stefania; Sieber Oliver M; Rowan Andrew; Setien Fernando; Neale Kay; Phillips Robin K S; Ward Robyn; Esteller Manel; Tomlinson Ian P M
Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations.

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All Publications

2009: Wijnen Juul T; Brohet Richard M; van Eijk Ronald; Jagmohan-Changur Shanty; Middeldorp Anneke; Tops Carli M; van Puijenbroek Mario; Ausems Margreet G E M; Gómez García Encarna; Hes Frederik J; Hoogerbrugge Nicoline; Menko Fred H; van Os Theo A M; Sijmons Rolf H; Verhoef Senno; Wagner Anja; Nagengast Fokko M; Kleibeuker Jan H; Devilee Peter; Morreau Hans; Goldgar David; Tomlinson Ian P; Houlston Richard S; van Wezel Tom; Vasen Hans F A
Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome.
Gastroenterology 2009;136(1):131-7.
2009: Segditsas S; Rowan A J; Howarth K; Jones A; Leedham S; Wright N A; Gorman P; Chambers W; Domingo E; Roylance R R; Sawyer E J; Sieber O M; Tomlinson I P M
APC and the three-hit hypothesis.
Oncogene 2009;28(1):146-55.
2008: Segditsas Stefania; Sieber Oliver M; Rowan Andrew; Setien Fernando; Neale Kay; Phillips Robin K S; Ward Robyn; Esteller Manel; Tomlinson Ian P M
Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations.
Experimental and molecular pathology 2008;85(3):201-6.
2008: Jones A M; Mitter R; Poulsom R; Gillett C; Hanby A M; Tomlinson I P M; Sawyer E J;
mRNA expression profiling of phyllodes tumours of the breast: identification of genes important in the development of borderline and malignant phyllodes tumours.
The Journal of pathology 2008;216(4):408-17.
2008: Ahvenainen Taru; Lehtonen Heli J; Lehtonen Rainer; Vahteristo Pia; Aittomäki Kristiina; Baynam Gareth; Dommering Charlotte; Eng Charis; Gruber Stephen B; Grönberg Henrik; Harvima Rauno; Herva Riitta; Hietala Marja; Kujala Minna; Kääriäinen Helena; Sunde Lone; Vierimaa Outi; Pollard Patrick J; Tomlinson Ian P M; Björck Erik; Aaltonen Lauri A; Launonen Virpi
Mutation screening of fumarate hydratase by multiplex ligation-dependent probe amplification: detection of exonic deletion in a patient with leiomyomatosis and renal cell cancer.
Cancer genetics and cytogenetics 2008;183(2):83-8.
2008: Alhopuro Pia; Phichith Denis; Tuupanen Sari; Sammalkorpi Heli; Nybondas Miranda; Saharinen Juha; Robinson James P; Yang Zhaohui; Chen Li-Qiong; Orntoft Torben; Mecklin Jukka-Pekka; Järvinen Heikki; Eng Charis; Moeslein Gabriela; Shibata Darryl; Houlston Richard S; Lucassen Anneke; Tomlinson Ian P M; Launonen Virpi; Ristimäki Ari; Arango Diego; Karhu Auli; Sweeney H Lee; Aaltonen Lauri A
Unregulated smooth-muscle myosin in human intestinal neoplasia.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(14):5513-8.
2008: Jones A M; Mitter R; Springall R; Graham T; Winter E; Gillett C; Hanby A M; Tomlinson I P M; Sawyer E J;
A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra-tumoral genetic heterogeneity and new genetic changes on recurrence.
The Journal of pathology 2008;214(5):533-44.
2008: Bayley Jean-Pierre; Launonen Virpi; Tomlinson Ian P M
The FH mutation database: an online database of fumarate hydratase mutations involved in the MCUL (HLRCC) tumor syndrome and congenital fumarase deficiency.
BMC medical genetics 2008;9():20.
2007: Hornsby Chris; Page Karen M; Tomlinson Ian P M
What can we learn from the population incidence of cancer? Armitage and Doll revisited.
The lancet oncology 2007;8(11):1030-8.
2007: Jones A M; Thirlwell C; Howarth K M; Graham T; Chambers W; Segditsas S; Page K M; Phillips R K S; Thomas H J W; Sieber O M; Sawyer E J; Tomlinson I P M
Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas.
The Journal of pathology 2007;213(3):249-56.
2007: Carvajal-Carmona L G; Howarth K M; Lockett M; Polanco-Echeverry G M; Volikos E; Gorman M; Barclay E; Martin L; Jones A M; Saunders B; Guenther T; Donaldson A; Paterson J; Frayling I; Novelli M R; Phillips R; Thomas H J W; Silver A; Atkin W; Tomlinson I P M
Molecular classification and genetic pathways in hyperplastic polyposis syndrome.
The Journal of pathology 2007;212(4):378-85.
2007: Thirlwell C; Howarth K M; Segditsas S; Guerra G; Thomas H J W; Phillips R K S; Talbot I C; Gorman M; Novelli M R; Sieber O M; Tomlinson I P M
Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations.
British journal of cancer 2007;96(11):1729-34.
2007: Vanharanta Sakari; Wortham Noel C; Langford Cordelia; El-Bahrawy Mona; van der Spuy Zephne; Sjöberg Jari; Lehtonen Rainer; Karhu Auli; Tomlinson Ian P M; Aaltonen Lauri A
Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling-path microarray CGH and mutation analysis of known genes in this region.
Genes, chromosomes & cancer 2007;46(5):451-8.
2007: Pollard Patrick J; Spencer-Dene Bradley; Shukla Deepa; Howarth Kimberley; Nye Emma; El-Bahrawy Mona; Deheragoda Maesha; Joannou Maria; McDonald Stuart; Martin Alison; Igarashi Peter; Varsani-Brown Sunita; Rosewell Ian; Poulsom Richard; Maxwell Patrick; Stamp Gordon W; Tomlinson Ian P M
Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway.
Cancer cell 2007;11(4):311-9.
2007: d'Onofrio Alberto; Tomlinson Ian P M
A nonlinear mathematical model of cell turnover, differentiation and tumorigenesis in the intestinal crypt.
Journal of theoretical biology 2007;244(3):367-74.
2006: Pollard Patrick J; El-Bahrawy Mona; Poulsom Richard; Elia George; Killick Pip; Kelly Gavin; Hunt Toby; Jeffery Rosemary; Seedhar Pooja; Barwell Julian; Latif Farida; Gleeson Michael J; Hodgson Shirley V; Stamp Gordon W; Tomlinson Ian P M; Maher Eamonn R
Expression of HIF-1alpha, HIF-2alpha (EPAS1), and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutations.
The Journal of clinical endocrinology and metabolism 2006;91(11):4593-8.
2006: Wortham Noel C; Alam N Afrina; Barclay Ella; Pollard Patrick J; Wagner Bart E; Manek Sanjiv; Elia George; Tomlinson Ian P M
Aberrant expression of apoptosis proteins and ultrastructural aberrations in uterine leiomyomas from patients with hereditary leiomyomatosis and renal cell carcinoma.
Fertility and sterility 2006;86(4):961-71.
2006: Sieber O M; Segditsas S; Knudsen A L; Zhang J; Luz J; Rowan A J; Spain S L; Thirlwell C; Howarth K M; Jaeger E E M; Robinson J; Volikos E; Silver A; Kelly G; Aretz S; Frayling I; Hutter P; Dunlop M; Guenther T; Neale K; Phillips R; Heinimann K; Tomlinson I P M
Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.
Gut 2006;55(10):1440-8.
2006: Carvajal-Carmona Luis G; Alam N Afrina; Pollard Patrick J; Jones Angela M; Barclay Ella; Wortham Noel; Pignatelli Massimo; Freeman Alex; Pomplun Sabine; Ellis Ian; Poulsom Richard; El-Bahrawy Mona A; Berney Daniel M; Tomlinson Ian P M
Adult leydig cell tumors of the testis caused by germline fumarate hydratase mutations.
The Journal of clinical endocrinology and metabolism 2006;91(8):3071-5.
2006: Prowse Amanda H; Manek Sanjiv; Varma Rajesh; Liu Jinsong; Godwin Andrew K; Maher Eamonn R; Tomlinson Ian P M; Kennedy Stephen H
Molecular genetic evidence that endometriosis is a precursor of ovarian cancer.
International journal of cancer. Journal international du cancer 2006;119(3):556-62.
2006: Volikos E; Robinson J; Aittomäki K; Mecklin J-P; Järvinen H; Westerman A M; de Rooji F W M; Vogel T; Moeslein G; Launonen V; Tomlinson I P M; Silver A R J; Aaltonen L A
LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome.
Journal of medical genetics 2006;43(5):e18.
2006: Gaasenbeek Michelle; Howarth Kimberley; Rowan Andrew J; Gorman Patricia A; Jones Angela; Chaplin Tracy; Liu Ying; Bicknell David; Davison Eleanor J; Fiegler Heike; Carter Nigel P; Roylance Rebecca R; Tomlinson Ian P M
Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex changes and multiple forms of chromosomal instability in colorectal cancers.
Cancer research 2006;66(7):3471-9.
2006: Mulholland Paul J; Fiegler Heike; Mazzanti Chiara; Gorman Patricia; Sasieni Peter; Adams Joanna; Jones Tania A; Babbage Jane W; Vatcheva Radost; Ichimura Koichi; East Philip; Poullikas Chrysanthos; Collins V Peter; Carter Nigel P; Tomlinson Ian P M; Sheer Denise
Genomic profiling identifies discrete deletions associated with translocations in glioblastoma multiforme.
Cell cycle (Georgetown, Tex.) 2006;5(7):783-91.
2006: Vanharanta Sakari; Pollard Patrick J; Lehtonen Heli J; Laiho Päivi; Sjöberg Jari; Leminen Arto; Aittomäki Kristiina; Arola Johanna; Kruhoffer Mogens; Orntoft Torben F; Tomlinson Ian P; Kiuru Maija; Arango Diego; Aaltonen Lauri A
Distinct expression profile in fumarate-hydratase-deficient uterine fibroids.
Human molecular genetics 2006;15(1):97-103.
2006: Kokko Antti; Laiho Päivi; Lehtonen Rainer; Korja Sanna; Carvajal-Carmona Luis G; Järvinen Heikki; Mecklin Jukka-Pekka; Eng Charis; Schleutker Johanna; Tomlinson Ian P M; Vahteristo Pia; Aaltonen Lauri A
EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis.
BMC cancer 2006;6():145.
2005: Davison Eleanor J; Tarpey Patrick S; Fiegler Heike; Tomlinson Ian P M; Carter Nigel P
Deletion at chromosome band 20p12.1 in colorectal cancer revealed by high resolution array comparative genomic hybridization.
Genes, chromosomes & cancer 2005;44(4):384-91.
2005: Gottlieb Eyal; Tomlinson Ian P M
Mitochondrial tumour suppressors: a genetic and biochemical update.
Nature reviews. Cancer 2005;5(11):857-66.
2005: Alam N Afrina; Olpin Simon; Rowan Andrew; Kelsell David; Leigh Irene M; Tomlinson Ian P M; Weaver Todd
Missense mutations in fumarate hydratase in multiple cutaneous and uterine leiomyomatosis and renal cell cancer.
The Journal of molecular diagnostics : JMD 2005;7(4):437-43.
2005: Johnson V; Lipton L R; Cummings C; Eftekhar Sadat A T; Izatt L; Hodgson S V; Talbot I C; Thomas H J W; Silver A J R; Tomlinson I P M
Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families.
Journal of medical genetics 2005;42(10):756-62.
2005: Vanharanta Sakari; Wortham Noel C; Laiho Päivi; Sjöberg Jari; Aittomäki Kristiina; Arola Johanna; Tomlinson Ian P; Karhu Auli; Arango Diego; Aaltonen Lauri A
7q deletion mapping and expression profiling in uterine fibroids.
Oncogene 2005;24(43):6545-54.
2005: Sieber Oliver M; Tomlinson Simon R; Tomlinson Ian P M
Tissue, cell and stage specificity of (epi)mutations in cancers.
Nature reviews. Cancer 2005;5(8):649-55.
2005: Pollard P J; Brière J J; Alam N A; Barwell J; Barclay E; Wortham N C; Hunt T; Mitchell M; Olpin S; Moat S J; Hargreaves I P; Heales S J; Chung Y L; Griffiths J R; Dalgleish A; McGrath J A; Gleeson M J; Hodgson S V; Poulsom R; Rustin P; Tomlinson I P M
Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations.
Human molecular genetics 2005;14(15):2231-9.
2005: Robinson James P; Johnson Victoria L; Rogers Pauline A; Houlston Richard S; Maher Earmonn R; Bishop D Timothy; Evans D Gareth R; Thomas Huw J W; Tomlinson Ian P M; Silver Andrew R J
Evidence for an association between compound heterozygosity for germ line mutations in the hemochromatosis (HFE) gene and increased risk of colorectal cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(6):1460-3.
2005: Suraweera Nirosha; Meijne Emmy; Moody John; Carvajal-Carmona Luis G; Yoshida Kazuko; Pollard Patrick; Fitzgibbon Jude; Riches Andrew; van Laar Theo; Huiskamp Rene; Rowan Andrew; Tomlinson Ian P M; Silver Andrew
Mutations of the PU.1 Ets domain are specifically associated with murine radiation-induced, but not human therapy-related, acute myeloid leukaemia.
Oncogene 2005;24(22):3678-83.
2005: Prowse Amanda H; Fakis Giannoulis; Manek Sanjiv; Churchman Michael; Edwards Sarah; Rowan Andrew; Koninckx Philippe; Kennedy Stephen; Tomlinson Ian P M
Allelic loss studies do not provide evidence for the "endometriosis-as-tumor" theory.
Fertility and sterility 2005;83 Suppl 1():1134-43.
2005: Alhopuro P; Katajisto P; Lehtonen R; Ylisaukko-Oja S K; Näätsaari L; Karhu A; Westerman A M; Wilson J H P; de Rooij F W M; Vogel T; Moeslein G; Tomlinson I P; Aaltonen L A; Mäkelä T P; Launonen V
Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome.
British journal of cancer 2005;92(6):1126-9.
2005: Alam N Afrina; Barclay Ella; Rowan Andrew J; Tyrer Jonathan P; Calonje Eduardo; Manek Sanjiv; Kelsell David; Leigh Irene; Olpin Simon; Tomlinson Ian P M
Clinical features of multiple cutaneous and uterine leiomyomatosis: an underdiagnosed tumor syndrome.
Archives of dermatology 2005;141(2):199-206.
2005: Johnson V; Volikos E; Halford S E; Eftekhar Sadat E T; Popat S; Talbot I; Truninger K; Martin J; Jass J; Houlston R; Atkin W; Tomlinson I P M; Silver A R J
Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in hereditary non-polyposis colorectal cancer syndrome.
Gut 2005;54(2):264-7.
2005: Lambros Maryou B K; Fiegler Heike; Jones Angela; Gorman Patricia; Roylance Rebecca R; Carter Nigel P; Tomlinson Ian P M
Analysis of ovarian cancer cell lines using array-based comparative genomic hybridization.
The Journal of pathology 2005;205(1):29-40.
2005: Jones Angela M; Douglas Eleanor J; Halford Sarah Er; Fiegler Heike; Gorman Patricia A; Roylance Rebecca R; Carter Nigel P; Tomlinson Ian P M
Array-CGH analysis of microsatellite-stable, near-diploid bowel cancers and comparison with other types of colorectal carcinoma.
Oncogene 2005;24(1):118-29.
2005: Truta Brindusa; Allen Brian A; Conrad Peggy G; Weinberg Vivian; Miller Glenn A; Pomponio Rob; Lipton Lara R; Guerra Germano; Tomlinson Ian P M; Sleisenger Marvin H; Kim Young S; Terdiman Jonathan P
A comparison of the phenotype and genotype in adenomatous polyposis patients with and without a family history.
Familial cancer 2005;4(2):127-33.
2004: Lipton L R; Johnson V; Cummings C; Fisher S; Risby P; Eftekhar Sadat A T; Cranston T; Izatt L; Sasieni P; Hodgson S V; Thomas H J W; Tomlinson I P M
Refining the Amsterdam Criteria and Bethesda Guidelines: testing algorithms for the prediction of mismatch repair mutation status in the familial cancer clinic.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(24):4934-43.
2004: Sieber Oliver M; Howarth Kimberley M; Thirlwell Christina; Rowan Andrew; Mandir Nikki; Goodlad Robert A; Gilkar Ashfaq; Spencer-Dene Bradley; Stamp Gordon; Johnson Victoria; Silver Andrew; Yang Hanjing; Miller Jeffrey H; Ilyas Mohammad; Tomlinson Ian P M
Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice.
Cancer research 2004;64(24):8876-81.
2004: Sturt N J H; Gallagher M C; Bassett P; Philp C R; Neale K F; Tomlinson I P M; Silver A R J; Phillips R K S
Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation.
Gut 2004;53(12):1832-6.
2004: Fearnhead Nicola S; Wilding Jennifer L; Winney Bruce; Tonks Susan; Bartlett Sylvia; Bicknell David C; Tomlinson Ian P M; Mortensen Neil J McC; Bodmer Walter F
Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(45):15992-7.
2004: Douglas Eleanor J; Fiegler Heike; Rowan Andrew; Halford Sarah; Bicknell David C; Bodmer Walter; Tomlinson Ian P M; Carter Nigel P
Array comparative genomic hybridization analysis of colorectal cancer cell lines and primary carcinomas.
Cancer research 2004;64(14):4817-25.
2004: Crabtree M D; Fletcher C; Churchman M; Hodgson S V; Neale K; Phillips R K S; Tomlinson I P M
Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases.
Gut 2004;53(2):271-6.
2003: Alam N A; Gorman P; Jaeger E E M; Kelsell D; Leigh I M; Ratnavel R; Murdoch M E; Houlston R S; Aaltonen L A; Roylance R R; Tomlinson I P M
Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability.
Cancer genetics and cytogenetics 2003;147(2):121-7.
2003: Lipton Lara; Halford Sarah E; Johnson Victoria; Novelli Marco R; Jones Angela; Cummings Carole; Barclay Ella; Sieber Oliver; Sadat Amir; Bisgaard Marie-Luise; Hodgson Shirley V; Aaltonen Lauri A; Thomas Huw J W; Tomlinson Ian P M
Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway.
Cancer research 2003;63(22):7595-9.
2003: Halford Sarah E R; Sawyer Elinor J; Lambros Maryou B; Gorman Patricia; Macdonald Nicola D; Talbot Ian C; Foulkes William D; Gillett Cheryl E; Barnes Diana M; Akslen Lars A; Lee Kwok; Jacobs Ian J; Hanby Andrew M; Ganesan Trivadi S; Salvesen Helga B; Bodmer Walter F; Tomlinson Ian P M; Roylance Rebecca R
MSI-low, a real phenomenon which varies in frequency among cancer types.
The Journal of pathology 2003;201(3):389-94.
2003: Lipton Lara; Fleischmann Christina; Sieber Oliver M; Thomas Huw J W; Hodgson Shirley V; Tomlinson Ian P M; Houlston Richard S
Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma.
Cancer letters 2003;200(2):149-52.
2003: Sieber Oliver M; Heinimann Karl; Tomlinson Ian P M
Genomic instability--the engine of tumorigenesis?
Nature reviews. Cancer 2003;3(9):701-8.
2003: Sawyer Elinor J; Hanby Andrew M; Poulsom Richard; Jeffery Rosemary; Gillett Cheryl E; Ellis Ian O; Ellis Paul; Tomlinson Ian P M
Beta-catenin abnormalities and associated insulin-like growth factor overexpression are important in phyllodes tumours and fibroadenomas of the breast.
The Journal of pathology 2003;200(5):627-32.
2003: Preston Sean L; Wong Wai-Man; Chan Annie On-On; Poulsom Richard; Jeffery Rosemary; Goodlad Robert A; Mandir Nikki; Elia George; Novelli Marco; Bodmer Walter F; Tomlinson Ian P; Wright Nicholas A
Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission.
Cancer research 2003;63(13):3819-25.
2003: Crabtree Michael; Sieber Oliver M; Lipton Lara; Hodgson Shirley V; Lamlum Hanan; Thomas Hunu J W; Neale Kay; Phillips Robin K S; Heinimann Karl; Tomlinson Ian P M
Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients.
Oncogene 2003;22(27):4257-65.
2003: Halford Sarah E R; Rowan Andrew J; Lipton Lara; Sieber Oliver M; Pack Kevin; Thomas Huw J W; Hodgson Shirley V; Bodmer Walter F; Tomlinson Ian P M
Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers.
The American journal of pathology 2003;162(5):1545-8.
2003: Jaeger E E M; Woodford-Richens K L; Lockett M; Rowan A J; Sawyer E J; Heinimann K; Rozen P; Murday V A; Whitelaw S C; Ginsberg A; Atkin W S; Lynch H T; Southey M C; Debinski H; Eng C; Bodmer W F; Talbot I C; Hodgson S V; Thomas H J W; Tomlinson I P M
An ancestral Ashkenazi haplotype at the HMPS/CRAC1 locus on 15q13-q14 is associated with hereditary mixed polyposis syndrome.
American journal of human genetics 2003;72(5):1261-7.
2003: Sawyer Elinor J; Poulsom Richard; Hunt F Toby; Jeffery Rosemary; Elia George; Ellis Ian O; Ellis Paul; Tomlinson Ian P M; Hanby Andrew M
Malignant phyllodes tumours show stromal overexpression of c-myc and c-kit.
The Journal of pathology 2003;200(1):59-64.
2003: Lipton L; Sieber O M; Thomas H J W; Hodgson S V; Tomlinson I P M; Woodford-Richens K
Germline mutations in the TGF-beta and Wnt signalling pathways are a rare cause of the "multiple" adenoma phenotype.
Journal of medical genetics 2003;40(4):e35.
2003: Fiegler Heike; Carr Philippa; Douglas Eleanor J; Burford Deborah C; Hunt Sarah; Scott Carol E; Smith James; Vetrie David; Gorman Patricia; Tomlinson Ian P M; Carter Nigel P
DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones.
Genes, chromosomes & cancer 2003;36(4):361-74.
2003: Sieber Oliver M; Lipton Lara; Crabtree Michael; Heinimann Karl; Fidalgo Paulo; Phillips Robin K S; Bisgaard Marie-Luise; Orntoft Torben F; Aaltonen Lauri A; Hodgson Shirley V; Thomas Huw J W; Tomlinson Ian P M
Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH.
The New England journal of medicine 2003;348(9):791-9.
2003: Pollard Patrick J; Wortham Noel C; Tomlinson Ian P M
The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase.
Annals of medicine 2003;35(8):632-9.
2002: Sieber O M; Heinimann K; Gorman P; Lamlum H; Crabtree M; Simpson C A; Davies D; Neale K; Hodgson S V; Roylance R R; Phillips R K S; Bodmer W F; Tomlinson I P M
Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16910-5.
2002: Crabtree M D; Tomlinson I P M; Hodgson S V; Neale K; Phillips R K S; Houlston R S
Explaining variation in familial adenomatous polyposis: relationship between genotype and phenotype and evidence for modifier genes.
Gut 2002;51(3):420-3.
2002: Sawyer E J; Cerar A; Hanby A M; Gorman P; Arends M; Talbot I C; Tomlinson I P M
Molecular characteristics of serrated adenomas of the colorectum.
Gut 2002;51(2):200-6.
2002: Tomlinson Ian P M; Lambros Maryou B K; Roylance Rebecca R
Loss of heterozygosity analysis: practically and conceptually flawed?
Genes, chromosomes & cancer 2002;34(4):349-53.
2002: Hao X P; Frayling I M; Sgouros J G; Du M Q; Willcocks T C; Talbot I C; Tomlinson I P M
The spectrum of p53 mutations in colorectal adenomas differs from that in colorectal carcinomas.
Gut 2002;50(6):834-9.
2002: Hao Xingpei; Frayling Ian M; Willcocks Teresa C; Han Wei; Tomlinson Ian P M; Pignatelli Massimo N; Pretlow Theresa P; Talbot Ian C
Beta-catenin expression and allelic loss at APC in sporadic colorectal carcinogenesis.
Virchows Archiv : an international journal of pathology 2002;440(4):362-6.
2002: Sawyer Elinor J; Hanby Andrew M; Rowan Andrew J; Gillett Cheryl E; Thomas Rachel E; Poulsom Richard; Lakhani Sunil R; Ellis Ian O; Ellis Paul; Tomlinson Ian P M
The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours.
The Journal of pathology 2002;196(4):437-44.
2002: Sieber O M; Lamlum H; Crabtree M D; Rowan A J; Barclay E; Lipton L; Hodgson S; Thomas H J W; Neale K; Phillips R K S; Farrington S M; Dunlop M G; Mueller H J; Bisgaard M L; Bulow S; Fidalgo P; Albuquerque C; Scarano M I; Bodmer W; Tomlinson I P M; Heinimann K
Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2954-8.
2001: Woodford-Richens K L; Rowan A J; Poulsom R; Bevan S; Salovaara R; Aaltonen L A; Houlston R S; Wright N A; Tomlinson I P
Comprehensive analysis of SMAD4 mutations and protein expression in juvenile polyposis: evidence for a distinct genetic pathway and polyp morphology in SMAD4 mutation carriers.
The American journal of pathology 2001;159(4):1293-300.
2001: Crabtree M D; Tomlinson I P; Talbot I C; Phillips R K
Variability in the severity of colonic disease in familial adenomatous polyposis results from differences in tumour initiation rather than progression and depends relatively little on patient age.
Gut 2001;49(4):540-3.
2001: Zhou X P; Woodford-Richens K; Lehtonen R; Kurose K; Aldred M; Hampel H; Launonen V; Virta S; Pilarski R; Salovaara R; Bodmer W F; Conrad B A; Dunlop M; Hodgson S V; Iwama T; Järvinen H; Kellokumpu I; Kim J C; Leggett B; Markie D; Mecklin J P; Neale K; Phillips R; Piris J; Rozen P; Houlston R S; Aaltonen L A; Tomlinson I P; Eng C
Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes.
American journal of human genetics 2001;69(4):704-11.
2001: Woodford-Richens K L; Rowan A J; Gorman P; Halford S; Bicknell D C; Wasan H S; Roylance R R; Bodmer W F; Tomlinson I P
SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(17):9719-23.
2001: Woodford-Richens K L; Halford S; Rowan A; Bevan S; Aaltonen L A; Wasan H; Bicknell D; Bodmer W F; Houlston R S; Tomlinson I P
CDX2 mutations do not account for juvenile polyposis or Peutz-Jeghers syndrome and occur infrequently in sporadic colorectal cancers.
British journal of cancer 2001;84(10):1314-6.
2001: Alam N A; Bevan S; Churchman M; Barclay E; Barker K; Jaeger E E; Nelson H M; Healy E; Pembroke A C; Friedmann P S; Dalziel K; Calonje E; Anderson J; August P J; Davies M G; Felix R; Munro C S; Murdoch M; Rendall J; Kennedy S; Leigh I M; Kelsell D P; Tomlinson I P; Houlston R S
Localization of a gene (MCUL1) for multiple cutaneous leiomyomata and uterine fibroids to chromosome 1q42.3-q43.
American journal of human genetics 2001;68(5):1264-9.
2001: Tomlinson I P; Roylance R; Houlston R S
Two hits revisited again.
Journal of medical genetics 2001;38(2):81-5.
2001: Lipton L; Thomas H J; Eeles R A; Houlston R S; Longmuir M; Davison R; Hodgson S V; Murday V A; Norbury C G; Taylor C; Tomlinson I P
Apparent Mendelian inheritance of breast and colorectal cancer: chance, genetic heterogeneity or a new gene?
Familial cancer 2001;1(3-4):189-95.
2000: Sieber O M; Tomlinson I P; Lamlum H
The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.
Molecular medicine today 2000;6(12):462-9.
2000: Woodford-Richens K; Bevan S; Churchman M; Dowling B; Jones D; Norbury C G; Hodgson S V; Desai D; Neale K; Phillips R K; Young J; Leggett B; Dunlop M; Rozen P; Eng C; Markie D; Rodriguez-Bigas M A; Sheridan E; Iwama T; Eccles D; Smith G T; Kim J C; Kim K M; Sampson J R; Evans G; Tejpar S; Bodmer W F; Tomlinson I P; Houlston R S
Analysis of genetic and phenotypic heterogeneity in juvenile polyposis.
Gut 2000;46(5):656-60.
2000: Rowan A J; Lamlum H; Ilyas M; Wheeler J; Straub J; Papadopoulou A; Bicknell D; Bodmer W F; Tomlinson I P
APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits".
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3352-7.
2000: Sawyer E J; Hanby A M; Ellis P; Lakhani S R; Ellis I O; Boyle S; Tomlinson I P
Molecular analysis of phyllodes tumors reveals distinct changes in the epithelial and stromal components.
The American journal of pathology 2000;156(3):1093-8.
1999: Novelli M R; Wasan H; Rosewell I; Bee J; Tomlinson I P; Wright N A; Bodmer W F
Tumor burden and clonality in multiple intestinal neoplasia mouse/normal mouse aggregation chimeras.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12553-8.
1999: Wheeler J M; Beck N E; Kim H C; Tomlinson I P; Mortensen N J; Bodmer W F
Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: the predominant role of hMLH1.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10296-301.
1999: Wang Z J; Churchman M; Avizienyte E; McKeown C; Davies S; Evans D G; Ferguson A; Ellis I; Xu W H; Yan Z Y; Aaltonen L A; Tomlinson I P
Germline mutations of the LKB1 (STK11) gene in Peutz-Jeghers patients.
Journal of medical genetics 1999;36(5):365-8.
1999: Wang Z J; Churchman M; Campbell I G; Xu W H; Yan Z Y; McCluggage W G; Foulkes W D; Tomlinson I P
Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours.
British journal of cancer 1999;80(1-2):70-2.
1999: Ylikorkala A; Avizienyte E; Tomlinson I P; Tiainen M; Roth S; Loukola A; Hemminki A; Johansson M; Sistonen P; Markie D; Neale K; Phillips R; Zauber P; Twama T; Sampson J; Järvinen H; Mäkelä T P; Aaltonen L A
Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.
Human molecular genetics 1999;8(1):45-51.
1999: Churchman M; Dowling B; Tomlinson I P
Identification of a novel mRNA species of the LKB1/STK11 Peutz-Jeghers serine/threonine kinase.
DNA sequence : the journal of DNA sequencing and mapping 1999;10(4-5):255-61.
1998: Marsh D J; Dahia P L; Caron S; Kum J B; Frayling I M; Tomlinson I P; Hughes K S; Eeles R A; Hodgson S V; Murday V A; Houlston R; Eng C
Germline PTEN mutations in Cowden syndrome-like families.
Journal of medical genetics 1998;35(11):881-5.
1998: Ilyas M; Hao X P; Wilkinson K; Tomlinson I P; Abbasi A M; Forbes A; Bodmer W F; Talbot I C
Loss of Bcl-2 expression correlates with tumour recurrence in colorectal cancer.
Gut 1998;43(3):383-7.
1998: Frayling I M; Beck N E; Ilyas M; Dove-Edwin I; Goodman P; Pack K; Bell J A; Williams C B; Hodgson S V; Thomas H J; Talbot I C; Bodmer W F; Tomlinson I P
The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10722-7.
1998: Homfray T F; Cottrell S E; Ilyas M; Rowan A; Talbot I C; Bodmer W F; Tomlinson I P
Defects in mismatch repair occur after APC mutations in the pathogenesis of sporadic colorectal tumours.
Human mutation 1998;11(2):114-20.
1997: Marsh D J; Roth S; Lunetta K L; Hemminki A; Dahia P L; Sistonen P; Zheng Z; Caron S; van Orsouw N J; Bodmer W F; Cottrell S E; Dunlop M G; Eccles D; Hodgson S V; Järvinen H; Kellokumpu I; Markie D; Neale K; Phillips R; Rozen P; Syngal S; Vijg J; Tomlinson I P; Aaltonen L A; Eng C
Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndrome.
Cancer research 1997;57(22):5017-21.
1997: Ilyas M; Tomlinson I P; Rowan A; Pignatelli M; Bodmer W F
Beta-catenin mutations in cell lines established from human colorectal cancers.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(19):10330-4.
1997: Tomlinson I P
Game-theory models of interactions between tumour cells.
European journal of cancer (Oxford, England : 1990) 1997;33(9):1495-500.
1997: Beck N E; Tomlinson I P; Homfray T F; Frayling I M; Hodgson S V; Bodmer W F
Frequency of germline hereditary non-polyposis colorectal cancer gene mutations in patients with multiple or early onset colorectal adenomas.
Gut 1997;41(2):235-8.
1997: Frayling I M; Bodmer W F; Tomlinson I P
Allele loss in colorectal cancer at the Cowden disease/juvenile polyposis locus on 10q.
Cancer genetics and cytogenetics 1997;97(1):64-9.
1997: Ilyas M; Tomlinson I P
The interactions of APC, E-cadherin and beta-catenin in tumour development and progression.
The Journal of pathology 1997;182(2):128-37.
1997: Tomlinson I P; Hampson R; Karran P; Bodmer W F
DNA mismatch repair in lymphoblastoid cells from hereditary non-polyposis colorectal cancer (HNPCC) patients is normal under conditions of rapid cell division and increased mutational load.
Mutation research 1997;383(2):177-82.
1997: Beck N E; Tomlinson I P; Homfray T; Hodgson S V; Harocopos C J; Bodmer W F
Genetic testing is important in families with a history suggestive of hereditary non-polyposis colorectal cancer even if the Amsterdam criteria are not fulfilled.
The British journal of surgery 1997;84(2):233-7.
1997: Beck N E; Tomlinson I P; Homfray T; Frayling I; Hodgson S V; Harocopos C; Bodmer W F
Use of SSCP analysis to identify germline mutations in HNPCC families fulfilling the Amsterdam criteria.
Human genetics 1997;99(2):219-24.
1997: Whitelaw S C; Murday V A; Tomlinson I P; Thomas H J; Cottrell S; Ginsberg A; Bukofzer S; Hodgson S V; Skudowitz R B; Jass J R; Talbot I C; Northover J M; Bodmer W F; Solomon E
Clinical and molecular features of the hereditary mixed polyposis syndrome.
Gastroenterology 1997;112(2):327-34.
1997: Tomlinson I P; Beck N E; Homfray T; Harocopos C J; Bodmer W F
Germline HNPCC gene variants have little influence on the risk for sporadic colorectal cancer.
Journal of medical genetics 1997;34(1):39-42.
1997: Tomlinson I P; Beck N E; Williamson J; Harocopos C J; Mitchell V E; Hodgson S V; Bodmer W F
Clinical features and molecular analysis of a family with multiple colon tumours and reduced plasminogen activator activity.
International journal of colorectal disease 1997;12(1):1-3.
1997: Tomlinson I P; Bodmer W F
Modelling the consequences of interactions between tumour cells.
British journal of cancer 1997;75(2):157-60.
1996: Tomlinson I P; Novelli M R; Bodmer W F
The mutation rate and cancer.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14800-3.
1996: Tomlinson I P; Ilyas M; Bodmer W F
Allele loss occurs frequently at hMLH1, but rarely at hMSH2, in sporadic colorectal cancers with microsatellite instability.
British journal of cancer 1996;74(10):1514-7.
1996: Ilyas M; Tomlinson I P; Hanby A M; Yao T; Bodmer W F; Talbot I C
Bcl-2 expression in colorectal tumors: evidence of different pathways in sporadic and ulcerative-colitis-associated carcinomas.
The American journal of pathology 1996;149(5):1719-26.
1996: Tomlinson I P; Beck N E; Bodmer W F
Allele loss on chromosome 11q and microsatellite instability in malignant melanoma.
European journal of cancer (Oxford, England : 1990) 1996;32A(10):1797-802.
1996: Tomlinson I P; Nicolai H; Solomon E; Bodmer W F
The frequency and mechanism of loss of heterozygosity on chromosome 11q in breast cancer.
The Journal of pathology 1996;180(1):38-43.
1996: Tomlinson I P; Olschwang S; Abelovitch D; Nakamura Y; Bodmer W F; Thomas G; Markie D
Testing candidate loci on chromosomes 1 and 6 for genetic linkage to Peutz-Jeghers' disease.
Annals of human genetics 1996;60(Pt 5):377-84.
1996: Tomlinson I P; Beck N E; Neale K; Bodmer W F
Variants at the secretory phospholipase A2 (PLA2G2A) locus: analysis of associations with familial adenomatous polyposis and sporadic colorectal tumours.
Annals of human genetics 1996;60(Pt 5):369-76.
1996: Ilyas M; Tomlinson I P; Novelli M R; Hanby A; Bodmer W F; Talbot I C
Clinico-pathological features and p53 expression in left-sided sporadic colorectal cancers with and without microsatellite instability.
The Journal of pathology 1996;179(4):370-5.
1996: Ilyas M; Tomlinson I P
Genetic pathways in colorectal cancer.
Histopathology 1996;28(5):389-99.
1996: Tomlinson I P; Bodmer W F
Chromosome 11q in sporadic colorectal carcinoma: patterns of allele loss and their significance for tumorigenesis.
Journal of clinical pathology 1996;49(5):386-90.
1996: Novelli M R; Williamson J A; Tomlinson I P; Elia G; Hodgson S V; Talbot I C; Bodmer W F; Wright N A
Polyclonal origin of colonic adenomas in an XO/XY patient with FAP.
Science (New York, N.Y.) 1996;272(5265):1187-90.
1996: Tomlinson I P; Neale K; Talbot I C; Spigelman A D; Williams C B; Phillips R K; Bodmer W F
A modifying locus for familial adenomatous polyposis may be present on chromosome 1p35-p36.
Journal of medical genetics 1996;33(4):268-73.
1996: Thomas H J; Whitelaw S C; Cottrell S E; Murday V A; Tomlinson I P; Markie D; Jones T; Bishop D T; Hodgson S V; Sheer D; Northover J M; Talbot I C; Solomon E; Bodmer W F
Genetic mapping of hereditary mixed polyposis syndrome to chromosome 6q.
American journal of human genetics 1996;58(4):770-6.
1995: Tomlinson I P; Bodmer W F
Failure of programmed cell death and differentiation as causes of tumors: some simple mathematical models.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(24):11130-4.
1995: Tomlinson I P; Whyman A; Barrett J A; Kremer J K
Tumour marker CA15-3: possible uses in the routine management of breast cancer.
European journal of cancer (Oxford, England : 1990) 1995;31A(6):899-902.

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