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Jeremy Tomlinson

Research Profile

Chemicals & Drugs

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Publications

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Jonathan M Hazlehurst; Maryam Nasiri; Paul M Stewart; Matthew J Armstrong; Sarah Borrows; Laura L Gathercole; Anton J M Wagenmakers; Jinglei Yu; Jeremy W Tomlinson
Glucocorticoids fail to cause insulin resistance in human subcutaneous adipose tissue in vivo.
Jonathan M Hazlehurst; Michael W O'Reilly; Ian A Rowe; Mark Sherlock; Paul M Stewart; Matthew J Armstrong; Jayne A Franklyn; Jeremy W Tomlinson
A comparative quality assessment of evidence-based clinical guidelines in endocrinology.
Laura L Gathercole; Stuart A Morgan; Jeremy W Tomlinson
Hormonal regulation of lipogenesis.

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All Publications

2013: Jonathan M Hazlehurst; Maryam Nasiri; Paul M Stewart; Matthew J Armstrong; Sarah Borrows; Laura L Gathercole; Anton J M Wagenmakers; Jinglei Yu; Jeremy W Tomlinson
Glucocorticoids fail to cause insulin resistance in human subcutaneous adipose tissue in vivo.
The Journal of clinical endocrinology and metabolism 2013;98(4):1631-40.
2013: Jonathan M Hazlehurst; Michael W O'Reilly; Ian A Rowe; Mark Sherlock; Paul M Stewart; Matthew J Armstrong; Jayne A Franklyn; Jeremy W Tomlinson
A comparative quality assessment of evidence-based clinical guidelines in endocrinology.
Clinical endocrinology 2013;78(2):183-90.
2013: Laura L Gathercole; Stuart A Morgan; Jeremy W Tomlinson
Hormonal regulation of lipogenesis.
Vitamins and hormones 2013;91():1-27.
2013: M J Armstrong; W H O Clausen; B Elbrønd; S C L Gough; D D Houlihan; I A Rowe; Jeremy W Tomlinson; P N Newsome
Safety and efficacy of liraglutide in patients with type 2 diabetes and elevated liver enzymes: individual patient data meta-analysis of the LEAD program.
Alimentary pharmacology & therapeutics 2013;37(2):234-42.
2013: Vasileios Chortis; Martin Fassnacht; Stefanie Hahner; Beverly A Hughes; Niki Karavitaki; Rossella Libé; Massimo Mannelli; Franco Mantero; Peter Nightingale; Donna M O'Neil; Giuseppe Opocher; Emilio Porfiri; Marcus Quinkler; Petra Schneider; Cedric H L Shackleton; Mark Sherlock; Paul M Stewart; Angela E Taylor; Massimo Terzolo; Jeremy W Tomlinson; Bruno Allolio; Xavier Bertagna; Jérôme Bertherat; Felix Beuschlein; Wiebke Arlt
Mitotane therapy in adrenocortical cancer induces CYP3A4 and inhibits 5α-reductase, explaining the need for personalized glucocorticoid and androgen replacement.
The Journal of clinical endocrinology and metabolism 2013;98(1):161-71.
2012: Gareth G Lavery; Stuart A Morgan; Elizabeth H Rabbitt; Gary Reynolds; KM Saqib; Nina Semjonous; Mark Sherlock; Laura L Gathercole; Phillip Guest; Beverly Hughes; Jeremy W Tomlinson; Elizabeth A Walker; Agnieszka E Zielinska; Paul M Stewart
Lack of significant metabolic abnormalities in mice with liver-specific disruption of 11β-hydroxysteroid dehydrogenase type 1.
Endocrinology 2012;153(7):3236-48.
2012: Philip Noel Newsome; J Oben; S Pollard; K J Simpson; D Thorburn; Jeremy W Tomlinson; J S Wyatt; M E Allison; P A Andrews; G Auzinger; C P Day; J W Ferguson; P A Henriksen; S G Hubscher; H Manley; P J McKiernan; C Millson; D Mirza; J M Neuberger
Guidelines for liver transplantation for patients with non-alcoholic steatohepatitis.
Gut 2012;61(4):484-500.
2012: Adeeba Ahmed; Theresa Brady; Claire Brown; Iwona J Bujalska; Craig Doig; Elwyn Elias; Peter Guest; Stefan Hubscher; Philip N Newsome; Elizabeth Rabbitt; David H Adams; Jeremy W Tomlinson; Paul M Stewart
A switch in hepatic cortisol metabolism across the spectrum of non alcoholic fatty liver disease.
PloS one 2012;7(2):e29531.
2012: Kirsty C McGee; Philip G McTernan; Peter Nightingale; Mohsen Shahmanesh; Fariba Shojaee-Moradie; Nasser M Al-Daghri; Meg Boothby; Satyajit Das; Laura L Gathercole; Alison L Harte; Gyanendra Tripathi; A Margot Umpleby; Jeremy W Tomlinson
Evidence for a shift to anaerobic metabolism in adipose tissue in efavirenz-containing regimens for HIV with different nucleoside backbones.
Antiviral therapy 2012;17(3):495-507.
2011: J K Dowman; Matthew J Armstrong; Jeremy W Tomlinson; P N Newsome
Current therapeutic strategies in non-alcoholic fatty liver disease.
Diabetes, obesity & metabolism 2011;13(8):692-702.
2011: L L Gathercole; S A Morgan; P M Stewart; Iwona J Bujalska; Jeremy W Tomlinson
Short- and long-term glucocorticoid treatment enhances insulin signalling in human subcutaneous adipose tissue.
Nutrition & diabetes 2011;1():e3.
2011: Laura L Gathercole; David Hauton; Stuart A Morgan; Paul M Stewart; Iwona J Bujalska; Jeremy W Tomlinson
Regulation of lipogenesis by glucocorticoids and insulin in human adipose tissue.
PloS one 2011;6(10):e26223.
2010: AJ Sinclair; Elizabeth A Walker; Michael A Burdon; A van Beek; Ido P Kema; Beverly A Hughes; Philip I Murray; Peter Nightingale; Paul M Stewart; Saaeha Rauz; Jeremy W Tomlinson
Cerebrospinal fluid corticosteroid levels and cortisol metabolism in patients with idiopathic intracranial hypertension: a link between 11beta-HSD1 and intracranial pressure regulation?
The Journal of clinical endocrinology and metabolism 2010;95(12):5348-56.
2010: Jeremy W Tomlinson; Andre Tchernof
Special issue on Steroids in Obesity and Diabetes.
The Journal of steroid biochemistry and molecular biology 2010;122(1-3):1-2.
2010: Stuart A Morgan; Jeremy W Tomlinson
11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes.
Expert opinion on investigational drugs 2010;19(9):1067-76.
2010: Mark Sherlock; John Ayuk; Jeremy W Tomlinson; Andrew A Toogood; Aurora Aragon-Alonso; Michael C Sheppard; Andrew S Bates; Paul M Stewart
Mortality in patients with pituitary disease.
Endocrine reviews 2010;31(3):301-42.
2010: J K Dowman; Jeremy W Tomlinson; P N Newsome
Pathogenesis of non-alcoholic fatty liver disease.
QJM : monthly journal of the Association of Physicians 2010;103(2):71-83.
2010: AJ Sinclair; Michael A Burdon; Peter G Nightingale; Alexandra K Ball; Peter Good; Timothy D Matthews; Andrew Jacks; Mark Lawden; Carl Clarke; Paul M Stewart; Elizabeth A Walker; Jeremy W Tomlinson; Saaeha Rauz
Low energy diet and intracranial pressure in women with idiopathic intracranial hypertension: prospective cohort study.
BMJ (Clinical research ed.) 2010;341():c2701.
2010: Jeremy W Tomlinson; Omar M Durrani; Iwona J Bujalska; Laura L Gathercole; Paul J Tomlins; Tristan T Q Reuser; Geoffrey E Rose; S John Curnow; Paul M Stewart; Elizabeth A Walker; Saaeha Rauz
The role of 11beta-hydroxysteroid dehydrogenase 1 in adipogenesis in thyroid-associated ophthalmopathy.
The Journal of clinical endocrinology and metabolism 2010;95(1):398-406.
2009: Stuart A Morgan; Mark Sherlock; Laura L Gathercole; Gareth G Lavery; Carol Lenaghan; Iwona J Bujalska; David Laber; Alice Yu; Gemma Convey; Rachel Mayers; Krisztina Hegyi; Jaswinder Sethi; Paul M Stewart; David M Smith; Jeremy W Tomlinson
11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.
Diabetes 2009;58(11):2506-15.
2009: Dimitra A Vassiliadi; Thomas M Barber; Beverly A Hughes; Mark I McCarthy; John A H Wass; Stephen Franks; Peter Nightingale; Jeremy W Tomlinson; Wiebke Arlt; Paul M Stewart
Increased 5 alpha-reductase activity and adrenocortical drive in women with polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism 2009;94(9):3558-66.
2009: A K Ball; Alan J Sinclair; S John Curnow; Jeremy W Tomlinson; M A Burdon; E A Walker; Paul M Stewart; Peter Nightingale; Carl Clarke; Saaeha Rauz
Elevated cerebrospinal fluid (CSF) leptin in idiopathic intracranial hypertension (IIH): evidence for hypothalamic leptin resistance?
Clinical endocrinology 2009;70(6):863-9.
2009: Meg Boothby; Kirsty C McGee; Jeremy W Tomlinson; Laura L Gathercole; Philip G McTernan; Fariba Shojaee-Moradie; A Margot Umpleby; Peter Nightingale; Mohsen Shahmanesh
Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months.
Antiviral therapy 2009;14(8):1089-100.
2009: Paul M Stewart; Jeremy W Tomlinson
Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both?
Diabetes 2009;58(1):14-5.
2008: A Swali; Elizabeth A Walker; Gareth G Lavery; Jeremy W Tomlinson; Paul M Stewart
11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets.
Diabetologia 2008;51(11):2003-11.
2008: Jeremy W Tomlinson; Joanne Finney; Christopher Gay; Beverly A Hughes; Susan V Hughes; Paul M Stewart
Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity.
Diabetes 2008;57(10):2652-60.
2008: Gareth G Lavery; Elizabeth A Walker; Ana Tiganescu; Jonathan P Ride; Cedric H L Shackleton; Jeremy W Tomlinson; John M C Connell; David W Ray; Anna Biason-Lauber; Ewa M Malunowicz; Wiebke Arlt; Paul M Stewart
Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency.
The Journal of clinical endocrinology and metabolism 2008;93(10):3827-32.
2008: J Holme; Jeremy W Tomlinson; Robert A Stockley; P M Stewart; N Barlow; A L Sullivan
Adrenal suppression in bronchiectasis and the impact of inhaled corticosteroids.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;32(4):1047-52.
2008: Jeremy W Tomlinson; Joanne Finney; Beverly A Hughes; Susan V Hughes; Paul M Stewart
Reduced glucocorticoid production rate, decreased 5alpha-reductase activity, and adipose tissue insulin sensitization after weight loss.
Diabetes 2008;57(6):1536-43.
2008: Iwona J Bujalska; L L Gathercole; Jeremy W Tomlinson; C Darimont; J Ermolieff; A N Fanjul; Paul Rejto; Paul M Stewart
A novel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis.
The Journal of endocrinology 2008;197(2):297-307.
2008: Iwona J Bujalska; Kylie N Hewitt; David Hauton; Gareth G Lavery; Jeremy W Tomlinson; Elizabeth A Walker; Paul M Stewart
Lack of hexose-6-phosphate dehydrogenase impairs lipid mobilization from mouse adipose tissue.
Endocrinology 2008;149(5):2584-91.
2008: Paul M Stewart; Anna Stears; Jeremy W Tomlinson; Morris J Brown
Regulation--the real threat to clinical research.
BMJ (Clinical research ed.) 2008;337():a1732.
2007: Jeremy W Tomlinson; Paul M Stewart
Modulation of glucocorticoid action and the treatment of type-2 diabetes.
Best practice & research. Clinical endocrinology & metabolism 2007;21(4):607-19.
2007: Laura L Gathercole; Iwona J Bujalska; Paul M Stewart; Jeremy W Tomlinson
Glucocorticoid modulation of insulin signaling in human subcutaneous adipose tissue.
The Journal of clinical endocrinology and metabolism 2007;92(11):4332-9.
2007: Elizabeth A Walker; Adeeba Ahmed; Gareth G Lavery; Jeremy W Tomlinson; So Youn Kim; Mark S Cooper; Jonathan P Ride; Beverly A Hughes; Cedric H L Shackleton; Patrick J McKiernan; Elwyn Elias; Janice Y Chou; Paul M Stewart
11beta-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function.
The Journal of biological chemistry 2007;282(37):27030-6.
2007: Susanna Wiegand; Anna Richardt; Thomas Remer; Stefan A Wudy; Jeremy W Tomlinson; Beverly Hughes; Annette Grüters; Paul M Stewart; Christian J Strasburger; Marcus Quinkler
Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys.
European journal of endocrinology / European Federation of Endocrine Societies 2007;157(3):319-24.
2007: A J Sinclair; Claire U Onyimba; Pamela Khosla; N Vijapurapu; Jeremy W Tomlinson; M A Burdon; Paul M Stewart; Philip I Murray; Elizabeth A Walker; Saaeha Rauz
Corticosteroids, 11beta-hydroxysteroid dehydrogenase isozymes and the rabbit choroid plexus.
Journal of neuroendocrinology 2007;19(8):614-20.
2007: Jeremy W Tomlinson; Mark Sherlock; Beverley Hughes; Susan V Hughes; Fiona Kilvington; William A Bartlett; Rachel Courtney; Paul Rejto; William Carley; Paul M Stewart
Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis.
The Journal of clinical endocrinology and metabolism 2007;92(3):857-64.
2007: Iwona J Bujalska; Omar M Durrani; Joseph Abbott; Claire U Onyimba; Pamela Khosla; Areeb H Moosavi; Tristan T Q Reuser; Paul M Stewart; Jeremy W Tomlinson; Elizabeth A Walker; Saaeha Rauz
Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat.
The Journal of endocrinology 2007;192(2):279-88.
2006: Iwona J Bujalska; Marcus Quinkler; Jeremy W Tomlinson; Montague Carl; D M Smith; Paul M Stewart
Expression profiling of 11beta-hydroxysteroid dehydrogenase type-1 and glucocorticoid-target genes in subcutaneous and omental human preadipocytes.
Journal of molecular endocrinology 2006;37(2):327-40.
2006: Marcus Quinkler; Iwona J Bujalska; Jeremy W Tomlinson; Dave M Smith; Paul M Stewart
Depot-specific prostaglandin synthesis in human adipose tissue: a novel possible mechanism of adipogenesis.
Gene 2006;380(2):137-43.
2006: Amar Agha; Jeremy W Tomlinson; Penny M S Clark; Geoff Holder; Paul M Stewart
The long-term predictive accuracy of the short synacthen (corticotropin) stimulation test for assessment of the hypothalamic-pituitary-adrenal axis.
The Journal of clinical endocrinology and metabolism 2006;91(1):43-7.
2005: Jeremy W Tomlinson; Paul M Stewart
Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome.
Nature clinical practice. Endocrinology & metabolism 2005;1(2):92-9.
2005: Iwona J Bujalska; Nicole Draper; Zoi Michailidou; Jeremy W Tomlinson; Perrin C White; Karen E Chapman; Elizabeth A Walker; Paul M Stewart
Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.
Journal of molecular endocrinology 2005;34(3):675-84.
2005: Jeremy W Tomlinson
11Beta-hydroxysteroid dehydrogenase type 1 in human disease: a novel therapeutic target.
Minerva endocrinologica 2005;30(1):37-46.
2004: Marcus Quinkler; Binayak Sinha; Jeremy W Tomlinson; Iwona J Bujalska; Paul M Stewart; Wiebke Arlt
Androgen generation in adipose tissue in women with simple obesity--a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5.
The Journal of endocrinology 2004;183(2):331-42.
2004: Jeremy W Tomlinson; Elizabeth A Walker; Iwona J Bujalska; Nicole Draper; Gareth G Lavery; Mark S Cooper; Martin Hewison; Paul M Stewart
11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
Endocrine reviews 2004;25(5):831-66.
2004: George Valsamakis; Aresh J Anwar; Jeremy W Tomlinson; Cedric H L Shackleton; Philip G McTernan; Rajkumar Chetty; Peter J Wood; A K Banerjee; Geoff Holder; Anthony H Barnett; Paul M Stewart; Sudhesh Kumar
11beta-hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism 2004;89(9):4755-61.
2004: Jeremy W Tomlinson; Jasbir S Moore; Penny M S Clark; Geoff Holder; Lynette Shakespeare; Paul M Stewart
Weight loss increases 11beta-hydroxysteroid dehydrogenase type 1 expression in human adipose tissue.
The Journal of clinical endocrinology and metabolism 2004;89(6):2711-6.
2004: Jeremy W Tomlinson; Paul M Stewart
"Cushing's disease of the omentum"--fact or fiction?
Journal of endocrinological investigation 2004;27(2):171-4.
2003: Nicole Draper; Elizabeth A Walker; Iwona J Bujalska; Jeremy W Tomlinson; Susan M Chalder; Wiebke Arlt; Gareth G Lavery; Oliver Bedendo; David W Ray; Ian Laing; Ewa M Malunowicz; Perrin C White; Martin Hewison; Philip Mason; John M C Connell; Cedric H L Shackleton; Paul M Stewart
Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency.
Nature genetics 2003;34(4):434-9.
2003: Jeremy W Tomlinson; Nicola Crabtree; Penny M S Clark; Geoff Holder; Andrew A Toogood; Cedric H L Shackleton; Paul M Stewart
Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity.
The Journal of clinical endocrinology and metabolism 2003;88(5):2113-8.
2002: Jeremy W Tomlinson; B Sinha; Iwona J Bujalska; Martin Hewison; Paul M Stewart
Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity.
The Journal of clinical endocrinology and metabolism 2002;87(12):5630-5.
2002: Jeremy W Tomlinson; Paul M Stewart
The functional consequences of 11beta-hydroxysteroid dehydrogenase expression in adipose tissue.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(11-12):746-51.
2002: Iwona J Bujalska; Elizabeth A Walker; Jeremy W Tomlinson; Martin Hewison; Paul M Stewart
11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol.
Endocrine research 2002;28(4):449-61.
2002: Jeremy W Tomlinson; Nicole Draper; Joanna Mackie; Alan P Johnson; Geoff Holder; Peter Wood; Paul M Stewart
Absence of Cushingoid phenotype in a patient with Cushing's disease due to defective cortisone to cortisol conversion.
The Journal of clinical endocrinology and metabolism 2002;87(1):57-62.
2001: Jeremy W Tomlinson; J Moore; Mark S Cooper; Iwona J Bujalska; Mohsen Shahmanesh; C Burt; Alastair J Strain; Martin Hewison; Paul M Stewart
Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines.
Endocrinology 2001;142(5):1982-9.
2001: Jeremy W Tomlinson; Paul M Stewart
Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.
Best practice & research. Clinical endocrinology & metabolism 2001;15(1):61-78.
2001: Jeremy W Tomlinson; N Holden; Robert K Hills; Keith Wheatley; Richard N Clayton; Andrew S Bates; Michael C Sheppard; Paul M Stewart
Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group.
Lancet 2001;357(9254):425-31.
2001: Paul M Stewart; Andrew A Toogood; Jeremy W Tomlinson
Growth hormone, insulin-like growth factor-I and the cortisol-cortisone shuttle.
Hormone research 2001;56 Suppl 1():1-6.
2000: Jeremy W Tomlinson; Iwona J Bujalska; Paul M Stewart; Mark S Cooper
The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis.
Endocrine research 2000;26(4):711-22.