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Kazuhiko Tomokiyo

Research Profile

Chemicals & Drugs

Disorders

Haemophilia B

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Platelet Count

Anatomy

Thrombosis

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Ultrafiltration

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Publications

TOP 3
Yasushi Nakatomi; Manami Tsuji; Soutaro Gokudan; Takayoshi Hamamoto; Takako Hanada-Dateki; Hiroki Miyazaki; Tomohiro Nakagaki; Teruhisa Nakashima; Kazuhiko Tomokiyo
Stable complex formation between serine protease inhibitor and zymogen: coagulation factor X cleaves the Arg393-Ser394 bond in a reactive centre loop of antithrombin in the presence of heparin.
Kazuhiko Tomokiyo; Yuichi Kamikubo; Takako Hanada; Tatsuya Araki; Yasushi Nakatomi; Yoichi Ogata; Stephanie M Jung; Tomohiro Nakagaki; Masaaki Moroi
Von Willebrand factor accelerates platelet adhesion and thrombus formation on a collagen surface in platelet-reduced blood under flow conditions.
Teruhisa Nakashima; Kazuhiko Tomokiyo
Large-scale preparation of factor VIIa from human plasma: a case study.

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2012: Yasushi Nakatomi; Manami Tsuji; Soutaro Gokudan; Takayoshi Hamamoto; Takako Hanada-Dateki; Hiroki Miyazaki; Tomohiro Nakagaki; Teruhisa Nakashima; Kazuhiko Tomokiyo
Stable complex formation between serine protease inhibitor and zymogen: coagulation factor X cleaves the Arg393-Ser394 bond in a reactive centre loop of antithrombin in the presence of heparin.
Journal of biochemistry 2012;152(5):463-70.
2005: Kazuhiko Tomokiyo; Yuichi Kamikubo; Takako Hanada; Tatsuya Araki; Yasushi Nakatomi; Yoichi Ogata; Stephanie M Jung; Tomohiro Nakagaki; Masaaki Moroi
Von Willebrand factor accelerates platelet adhesion and thrombus formation on a collagen surface in platelet-reduced blood under flow conditions.
Blood 2005;105(3):1078-84.
2005: Teruhisa Nakashima; Kazuhiko Tomokiyo
Large-scale preparation of factor VIIa from human plasma: a case study.
Methods in molecular biology (Clifton, N.J.) 2005;308():177-90.
2003: Kazuhiko Tomokiyo; Yasushi Nakatomi; T Araki; K Teshima; H Nakano; Tomohiro Nakagaki; S Miyamoto; A Funatsu; Sadaaki Iwanaga
A novel therapeutic approach combining human plasma-derived Factors VIIa and X for haemophiliacs with inhibitors: evidence of a higher thrombin generation rate in vitro and more sustained haemostatic activity in vivo than obtained with Factor VIIa alone.
Vox sanguinis 2003;85(4):290-9.
2003: Kazuhiko Tomokiyo; H Yano; M Imamura; Y Nakano; Tomohiro Nakagaki; Y Ogata; T Terano; S Miyamoto; A Funatsu
Large-scale production and properties of human plasma-derived activated Factor VII concentrate.
Vox sanguinis 2003;84(1):54-64.
2002: Kenji Soejima; Masato Yuguchi; Jun Mizuguchi; Kazuhiko Tomokiyo; Toshihiro Nakashima; Tomohiro Nakagaki; Sadaaki Iwanaga
The 99 and 170 loop-modified factor VIIa mutants show enhanced catalytic activity without tissue factor.
The Journal of biological chemistry 2002;277(50):49027-35.
2001: Kazuhiko Tomokiyo; K Teshima; Yasushi Nakatomi; T Watanabe; Jun Mizuguchi; Chikateru Nozaki; Tomohiro Nakagaki; S Miyamoto; A Funatsu; Sadaaki Iwanaga
Induction of acquired factor IX inhibitors in cynomolgus monkey (Macaca fascicularis): a new primate model of hemophilia B.
Thrombosis research 2001;102(4):363-74.