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Hideaki Tomura

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Takashi Nakakura; Hiroshi Ohnishi; Akihiro Harada; Tadahiro Kitamura; Masaki Kobayashi; Chihiro Mogi; Koichi Sato; Tetsuya Sugiyama; Shigeyasu Tanaka; Masayuki Tobo; Hideaki Tomura; Mitsutoshi Wayama; Fumikazu Okajima
Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion.
Mayumi Komachi; Chihiro Mogi; Hideo Ohta; Koichi Sato; Izumi Takeyoshi; Masayuki Tobo; Hideaki Tomura; Takayuki Yamada; Keisuke Yanagida; Dong-Soon Im; Satoshi Ishii; Takao Kimura; Fumikazu Okajima
Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo.
Xiao-dong He; Mayumi Komachi; Chihiro Mogi; Naoya Murata; Takashi Nakakura; Koichi Sato; Mutsumi Takano; Masayuki Tobo; Hideaki Tomura; Fumikazu Okajima
Involvement of proton-sensing receptor TDAG8 in the anti-inflammatory actions of dexamethasone in peritoneal macrophages.

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All Publications

2012: Takashi Nakakura; Hiroshi Ohnishi; Akihiro Harada; Tadahiro Kitamura; Masaki Kobayashi; Chihiro Mogi; Koichi Sato; Tetsuya Sugiyama; Shigeyasu Tanaka; Masayuki Tobo; Hideaki Tomura; Mitsutoshi Wayama; Fumikazu Okajima
Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion.
Endocrinology 2012;153(9):4171-80.
2012: Mayumi Komachi; Chihiro Mogi; Hideo Ohta; Koichi Sato; Izumi Takeyoshi; Masayuki Tobo; Hideaki Tomura; Takayuki Yamada; Keisuke Yanagida; Dong-Soon Im; Satoshi Ishii; Takao Kimura; Fumikazu Okajima
Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo.
Cancer science 2012;103(6):1099-104.
2011: Xiao-dong He; Mayumi Komachi; Chihiro Mogi; Naoya Murata; Takashi Nakakura; Koichi Sato; Mutsumi Takano; Masayuki Tobo; Hideaki Tomura; Fumikazu Okajima
Involvement of proton-sensing receptor TDAG8 in the anti-inflammatory actions of dexamethasone in peritoneal macrophages.
Biochemical and biophysical research communications 2011;415(4):627-31.
2011: Shinichi Matsuzaki; Chihiro Mogi; Masatomo Mori; Akihiro Ono; Koichi Sato; Hideaki Tomura; Hiroaki Tsurumaki; Hidenori Yamada; Masakiyo Yatomi; Haruka Aoki; Kunio Dobashi; Takeshi Hisada; Isao Ichimonji; Tamotsu Ishizuka; Yosuke Kamide; Yasuhiko Koga; Mayumi Komachi; Fumikazu Okajima
Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth muscle cells.
Biochemical and biophysical research communications 2011;413(4):499-503.
2011: Takao Kimura; Hitoshi Kurose; Atsushi Kuwabara; Chihiro Mogi; Masami Murakami; Hideo Ohta; Koichi Sato; Hideaki Tomura; Dong-Soon Im; Fumikazu Okajima
p2y5/LPA(6) attenuates LPA(1)-mediated VE-cadherin translocation and cell-cell dissociation through G(12/13) protein-Src-Rap1.
Cardiovascular research 2011;92(1):149-58.
2011: Tsuyoshi Uchiyama; Shoichi Tomono; Toshihiro Utsugi; Yoshio Ohyama; Tetsuya Nakamura; Hideaki Tomura; Shoji Kawazu; Fumikazu Okajima; Masahiko Kurabayashi
Constitutively active heat shock factor 1 enhances glucose-driven insulin secretion.
Metabolism: clinical and experimental 2011;60(6):789-98.
2010: Shinichi Matsuzaki; Tamotsu Ishizuka; Takeshi Hisada; Haruka Aoki; Mayumi Komachi; Isao Ichimonji; Mitsuyoshi Utsugi; Akihiro Ono; Yasuhiko Koga; Kunio Dobashi; Hitoshi Kurose; Hideaki Tomura; Masatomo Mori; Fumikazu Okajima
Lysophosphatidic acid inhibits CC chemokine ligand 5/RANTES production by blocking IRF-1-mediated gene transcription in human bronchial epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(8):4863-72.
2010: Isao Ichimonji; Hideaki Tomura; Chihiro Mogi; Koichi Sato; Haruka Aoki; Takeshi Hisada; Kunio Dobashi; Tamotsu Ishizuka; Masatomo Mori; Fumikazu Okajima
Extracellular acidification stimulates IL-6 production and Ca(2+) mobilization through proton-sensing OGR1 receptors in human airway smooth muscle cells.
American journal of physiology. Lung cellular and molecular physiology 2010;299(4):L567-77.
2010: Jin-Peng Liu; Mayumi Komachi; Hideaki Tomura; Chihiro Mogi; Alatangaole Damirin; Masayuki Tobo; Mutsumi Takano; Hiromi Nochi; Koichi Tamoto; Koichi Sato; Fumikazu Okajima
Ovarian cancer G protein-coupled receptor 1-dependent and -independent vascular actions to acidic pH in human aortic smooth muscle cells.
American journal of physiology. Heart and circulatory physiology 2010;299(3):H731-42.
2010: Takao Kimura; Koichi Sato; Hideaki Tomura; Fumikazu Okajima
Cross-talk between exogenous statins and endogenous high-density lipoprotein in anti-inflammatory and anti-atherogenic actions.
Endocrine, metabolic & immune disorders drug targets 2010;10(1):8-15.
2010: Takao Kimura; Hideaki Tomura; Koichi Sato; Masaaki Ito; Isao Matsuoka; Dong-Soon Im; Atsushi Kuwabara; Chihiro Mogi; Hiroshi Itoh; Hitoshi Kurose; Masami Murakami; Fumikazu Okajima
Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells.
The Journal of biological chemistry 2010;285(7):4387-97.
2009: Enkhzol Malchinkhuu; Koichi Sato; Tomohiko Maehama; Shogo Ishiuchi; Yuhei Yoshimoto; Chihiro Mogi; Takao Kimura; Hitoshi Kurose; Hideaki Tomura; Fumikazu Okajima
Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid--induced migration by isoproterenol in glioma cells.
Molecular biology of the cell 2009;20(24):5156-65.
2009: Mayumi Komachi; Alatangaole Damirin; Enkhzol Malchinkhuu; Chihiro Mogi; Masayuki Tobo; Hideo Ohta; Koichi Sato; Hideaki Tomura; Fumikazu Okajima
Signaling pathways involved in DNA synthesis and migration in response to lysophosphatidic acid and low-density lipoprotein in coronary artery smooth muscle cells.
Vascular pharmacology 2009;50(5-6):178-84.
2009: Chihiro Mogi; Masayuki Tobo; Hideaki Tomura; Naoya Murata; Xiao-dong He; Koichi Sato; Takao Kimura; Tamotsu Ishizuka; Takehiko Sasaki; Takashi Sato; Yasuyuki Kihara; Satoshi Ishii; Akihiro Harada; Fumikazu Okajima
Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(5):3243-51.
2009: Mayumi Komachi; Hideaki Tomura; Enkhzol Malchinkhuu; Masayuki Tobo; Chihiro Mogi; Takayuki Yamada; Takao Kimura; Atsushi Kuwabara; Hideo Ohta; Dong-Soon Im; Hitoshi Kurose; Izumi Takeyoshi; Koichi Sato; Fumikazu Okajima
LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites.
Carcinogenesis 2009;30(3):457-65.
2009: Naoya Murata; Chihiro Mogi; Masayuki Tobo; Takashi Nakakura; Koichi Sato; Hideaki Tomura; Fumikazu Okajima
Inhibition of superoxide anion production by extracellular acidification in neutrophils.
Cellular immunology 2009;259(1):21-6.
2008: Takao Kimura; Chihiro Mogi; Hideaki Tomura; Atsushi Kuwabara; Dong-Soon Im; Koichi Sato; Hitoshi Kurose; Masami Murakami; Fumikazu Okajima
Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):7332-40.
2008: Ji-Yeong Jo; Hyo-Lim Kim; Yun-Kyung Lee; Hideaki Tomura; Yoe-Sik Bae; Fumikazu Okajima; Dong-Soon Im
N,N-Dimethyl-D-erythro-sphingosine inhibits store-operated Ca2+ entry in U937 monocytes.
Journal of pharmacological sciences 2008;107(3):303-7.
2008: Hideaki Tomura; Ju-Qiang Wang; Jin-Peng Liu; Mayumi Komachi; Alatangaole Damirin; Chihiro Mogi; Masayuki Tobo; Hiromi Nochi; Koichi Tamoto; Dong-Soon Im; Koichi Sato; Fumikazu Okajima
Cyclooxygenase-2 expression and prostaglandin E2 production in response to acidic pH through OGR1 in a human osteoblastic cell line.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008;23(7):1129-39.
2008: Enkhzol Malchinkhuu; Koichi Sato; Tomohiko Maehama; Chihiro Mogi; Hideaki Tomura; Shogo Ishiuchi; Yuhei Yoshimoto; Hitoshi Kurose; Fumikazu Okajima
S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN.
Biochemical and biophysical research communications 2008;366(4):963-8.
2007: Koichi Sato; Enkhzol Malchinkhuu; Yuta Horiuchi; Chihiro Mogi; Hideaki Tomura; Masahiko Tosaka; Yuhei Yoshimoto; Atsushi Kuwabara; Fumikazu Okajima
Critical role of ABCA1 transporter in sphingosine 1-phosphate release from astrocytes.
Journal of neurochemistry 2007;103(6):2610-9.
2007: Koichi Sato; Enkhzol Malchinkhuu; Yuta Horiuchi; Chihiro Mogi; Hideaki Tomura; Masahiko Tosaka; Yuhei Yoshimoto; Atsushi Kuwabara; Fumikazu Okajima
HDL-like lipoproteins in cerebrospinal fluid affect neural cell activity through lipoprotein-associated sphingosine 1-phosphate.
Biochemical and biophysical research communications 2007;359(3):649-54.
2007: Masayuki Tobo; Hideaki Tomura; Chihiro Mogi; Ju-Qiang Wang; Jin-Peng Liu; Mayumi Komachi; Alatangaole Damirin; Takao Kimura; Naoya Murata; Hitoshi Kurose; Koichi Sato; Fumikazu Okajima
Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms.
Cellular signalling 2007;19(8):1745-53.
2007: Alatangaole Damirin; Hideaki Tomura; Mayumi Komachi; Jin-Peng Liu; Chihiro Mogi; Masayuki Tobo; Ju-Qiang Wang; Takao Kimura; Atsushi Kuwabara; Yuji Yamazaki; Hideo Ohta; Dong-Soon Im; Koichi Sato; Fumikazu Okajima
Role of lipoprotein-associated lysophospholipids in migratory activity of coronary artery smooth muscle cells.
American journal of physiology. Heart and circulatory physiology 2007;292(5):H2513-22.
2007: Tsuyoshi Uchiyama; Hiroyuki Atsuta; Toshihiro Utsugi; Masato Oguri; Akira Hasegawa; Tetsuya Nakamura; Akira Nakai; Masanori Nakata; Ikuro Maruyama; Hideaki Tomura; Fumikazu Okajima; Shoichi Tomono; Shoji Kawazu; Ryozo Nagai; Masahiko Kurabayashi
HSF1 and constitutively active HSF1 improve vascular endothelial function (heat shock proteins improve vascular endothelial function).
Atherosclerosis 2007;190(2):321-9.
2006: Takao Kimura; Hideaki Tomura; Chihiro Mogi; Atsushi Kuwabara; Alatangaole Damirin; Tamotsu Ishizuka; Akihiro Sekiguchi; Mitsuteru Ishiwara; Dong-Soon Im; Koichi Sato; Masami Murakami; Fumikazu Okajima
Role of scavenger receptor class B type I and sphingosine 1-phosphate receptors in high density lipoprotein-induced inhibition of adhesion molecule expression in endothelial cells.
The Journal of biological chemistry 2006;281(49):37457-67.
2006: Tsuyoshi Uchiyama; Hiroyuki Atsuta; Toshihiro Utsugi; Yoshio Ohyama; Tetsuya Nakamura; Akira Nakai; Masanori Nakata; Ikuro Maruyama; Hideaki Tomura; Fumikazu Okajima; Shoichi Tomono; Shoji Kawazu; Ryozo Nagai; Masahiko Kurarbayashi
Simvastatin induces heat shock factor 1 in vascular endothelial cells.
Atherosclerosis 2006;188(2):265-73.
2006: Takao Kimura; Hideaki Tomura; Chihiro Mogi; Atsushi Kuwabara; Mitsuteru Ishiwara; Kunihiko Shibasawa; Koichi Sato; Susumu Ohwada; Dong-Soon Im; Hitoshi Kurose; Tamotsu Ishizuka; Masami Murakami; Fumikazu Okajima
Sphingosine 1-phosphate receptors mediate stimulatory and inhibitory signalings for expression of adhesion molecules in endothelial cells.
Cellular signalling 2006;18(6):841-50.
2005: Hideaki Tomura; Chihiro Mogi; Koichi Sato; Fumikazu Okajima
Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: a novel type of multi-functional receptors.
Cellular signalling 2005;17(12):1466-76.
2005: Hideaki Tomura; Ju-Qiang Wang; Mayumi Komachi; Alatangaole Damirin; Chihiro Mogi; Masayuki Tobo; Junko Kon; Norihiko Misawa; Koichi Sato; Fumikazu Okajima
Prostaglandin I(2) production and cAMP accumulation in response to acidic extracellular pH through OGR1 in human aortic smooth muscle cells.
The Journal of biological chemistry 2005;280(41):34458-64.
2005: Enkhzol Malchinkhuu; Koichi Sato; Yuta Horiuchi; Chihiro Mogi; Susumu Ohwada; Shogo Ishiuchi; Nobuhito Saito; Hitoshi Kurose; Hideaki Tomura; Fumikazu Okajima
Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells.
Oncogene 2005;24(44):6676-88.
2005: Chihiro Mogi; Hideaki Tomura; Masayuki Tobo; Ju-Qiang Wang; Alatangaole Damirin; Junko Kon; Mayumi Komachi; Kinji Hashimoto; Koichi Sato; Fumikazu Okajima
Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation.
Journal of pharmacological sciences 2005;99(2):160-7.
2005: Tadayoshi Kawata; Tamotsu Ishizuka; Hideaki Tomura; Takeshi Hisada; Kunio Dobashi; Hideo Tsukagoshi; Mitsuteru Ishiwara; Hitoshi Kurose; Masatomo Mori; Fumikazu Okajima
Sphingosine 1-phosphate inhibits migration and RANTES production in human bronchial smooth muscle cells.
Biochemical and biophysical research communications 2005;331(2):640-7.
2005: Alatangaole Damirin; Hideaki Tomura; Mayumi Komachi; Masayuki Tobo; Koichi Sato; Chihiro Mogi; Hiromi Nochi; Koichi Tamoto; Fumikazu Okajima
Sphingosine 1-phosphate receptors mediate the lipid-induced cAMP accumulation through cyclooxygenase-2/prostaglandin I2 pathway in human coronary artery smooth muscle cells.
Molecular pharmacology 2005;67(4):1177-85.
2005: Young-Jin Im; Dong-Soon Im; Yun-Kyung Lee; Eun-Hee Lee; Koichi Sato; Hideaki Tomura; Toshiaki Katada; Michio Ui; Fumikazu Okajima
Study on action mode of sphingosine 1-phosphate in rat hepatocytes.
Journal of pharmacological sciences 2005;97(3):443-6.
2005: Koichi Sato; Enkhzol Malchinkhuu; Takeshi Muraki; Koichi Ishikawa; Kensuke Hayashi; Masahiko Tosaka; Akikazu Mochiduki; Kinji Inoue; Hideaki Tomura; Chihiro Mogi; Hiromi Nochi; Koichi Tamoto; Fumikazu Okajima
Identification of autotaxin as a neurite retraction-inducing factor of PC12 cells in cerebrospinal fluid and its possible sources.
Journal of neurochemistry 2005;92(4):904-14.
2005: Bo Zhang; Hideaki Tomura; Atsushi Kuwabara; Takao Kimura; Shin-Ichiro Miura; Keita Noda; Fumikazu Okajima; Keijiro Saku
Correlation of high density lipoprotein (HDL)-associated sphingosine 1-phosphate with serum levels of HDL-cholesterol and apolipoproteins.
Atherosclerosis 2005;178(1):199-205.
2005: Kenichi Tamama; Hideaki Tomura; Koichi Sato; Enkhzol Malchinkhuu; Alatangaole Damirin; Takao Kimura; Atsushi Kuwabara; Masami Murakami; Fumikazu Okajima
High-density lipoprotein inhibits migration of vascular smooth muscle cells through its sphingosine 1-phosphate component.
Atherosclerosis 2005;178(1):19-23.
2004: Søren M Echwald; Kirstine L Andersen; Thorkild I A Sørensen; Lesli H Larsen; Teis Andersen; Naoko Tonooka; Hideaki Tomura; Jun Takeda; Oluf Pedersen
Mutation analysis of NR0B2 among 1545 Danish men identifies a novel c.278G>A (p.G93D) variant with reduced functional activity.
Human mutation 2004;24(5):381-7.
2004: Ju-Qiang Wang; Junko Kon; Chihiro Mogi; Masayuki Tobo; Alatangaole Damirin; Koichi Sato; Mayumi Komachi; Enkhzol Malchinkhuu; Naoya Murata; Takao Kimura; Atsushi Kuwabara; Kaori Wakamatsu; Hideki Koizumi; Toshimitsu Uede; Gozoh Tsujimoto; Hitoshi Kurose; Takashi Sato; Akihiro Harada; Norihiko Misawa; Hideaki Tomura; Fumikazu Okajima
TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor.
The Journal of biological chemistry 2004;279(44):45626-33.
2004: Dong-Soon Im; Hideaki Tomura; Masayuki Tobo; Masayuki Tobe; Koichi Sato; Fumikazu Okajima
Enhancement of sphingosine 1-phosphate-induced phospholipase C activation during G(0)-G(1) transition in rat hepatocytes.
Journal of pharmacological sciences 2004;95(2):284-90.
2004: Takayuki Yamada; Koichi Sato; Mayumi Komachi; Enkhzol Malchinkhuu; Masayuki Tobo; Takao Kimura; Atsushi Kuwabara; Yasuhiro Yanagita; Toshiro Ikeya; Yoshifumi Tanahashi; Tetsushi Ogawa; Susumu Ohwada; Yasuo Morishita; Hideo Ohta; Dong-Soon Im; Koichi Tamoto; Hideaki Tomura; Fumikazu Okajima
Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.
The Journal of biological chemistry 2004;279(8):6595-605.
2003: Hideo Ohta; Koichi Sato; Naoya Murata; Alatangaole Damirin; Enkhzol Malchinkhuu; Junko Kon; Takao Kimura; Masayuki Tobo; Yuji Yamazaki; Tomoko Watanabe; Mikio Yagi; Motoko Sato; Rika Suzuki; Hideko Murooka; Teruyuki Sakai; Tsuyoshi Nishitoba; Dong-Soon Im; Hiromi Nochi; Koichi Tamoto; Hideaki Tomura; Fumikazu Okajima
Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors.
Molecular pharmacology 2003;64(4):994-1005.
2003: Takao Kimura; Koichi Sato; Enkhzol Malchinkhuu; Hideaki Tomura; Kenichi Tamama; Atsushi Kuwabara; Masami Murakami; Fumikazu Okajima
High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(7):1283-8.
2002: Naoko Tonooka; Hideaki Tomura; Y Takahashi; Kazumichi Onigata; N Kikuchi; Y Horikawa; Masatomo Mori; Jun Takeda
High frequency of mutations in the HNF-1alpha gene in non-obese patients with diabetes of youth in Japanese and identification of a case of digenic inheritance.
Diabetologia 2002;45(12):1709-12.
2002: Hitoshi Nishizawa; Kazuya Yamagata; Iichiro Shimomura; Masahiko Takahashi; Hiroshi Kuriyama; Ken Kishida; Kikuko Hotta; Hiroyuki Nagaretani; Norikazu Maeda; Morihiro Matsuda; Shinji Kihara; Tadashi Nakamura; Hidekazu Nishigori; Hideaki Tomura; David D Moore; Jun Takeda; Tohru Funahashi; Yuji Matsuzawa
Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor gamma transactivation.
The Journal of biological chemistry 2002;277(2):1586-92.
2002: Takayuki Yamada; Fumikazu Okajima; Mohammed Akbar; Hideaki Tomura; Torao Narita; Tatsuya Yamada; Susumu Ohwada; Yasuo Morishita; Yoichi Kondo
Cell cycle arrest and the induction of apoptosis in pancreatic cancer cells exposed to adenosine triphosphate in vitro.
Oncology reports 2002;9(1):113-7.
2001: Takao Kimura; Ken Sato; Atsushi Kuwabara; Hideaki Tomura; Mitsuteru Ishiwara; Isao Kobayashi; Michio Ui; Fumikazu Okajima
Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells.
The Journal of biological chemistry 2001;276(34):31780-5.
2001: L Yu; Q Wei; L Jin; Hidekazu Nishigori; T Nishigori; Hideaki Tomura; J Fujita; Y Yamada; Y Seino; Jun Takeda
Genetic variation in the hepatocyte nuclear factor (HNF)-3alpha gene does not contribute to maturity-onset diabetes of the young in Japanese.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2001;33(3):163-6.
2001: Hidekazu Nishigori; Hideaki Tomura; Naoko Tonooka; M Kanamori; Satoko Yamada; K Sho; I Inoue; N Kikuchi; Kazumichi Onigata; Itaru Kojima; T Kohama; Kazuya Yamagata; Q Yang; Yuji Matsuzawa; T Miki; Susumu Seino; M Y Kim; H S Choi; Y K Lee; D D Moore; Jun Takeda
Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(2):575-80.
2001: Y Aihara; H Onda; M Teraoka; Y Yokoyama; Y Seino; H Kasuya; T Hori; Hideaki Tomura; I Inoue; Itaru Kojima; Jun Takeda
Assignment of SLC17A6 (alias DNPI), the gene encoding brain/pancreatic islet-type Na+-dependent inorganic phosphate cotransporter to human chromosome 11p14.3.
Cytogenetics and cell genetics 2001;92(1-2):167-9.
2001: Kenichi Tamama; Junko Kon; Ken Sato; Hideaki Tomura; Atsushi Kuwabara; Takao Kimura; Tsugiyasu Kanda; Hideo Ohta; Michio Ui; Isao Kobayashi; Fumikazu Okajima
Extracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cells.
The Biochemical journal 2001;353(Pt 1):139-146.
2000: Naoya Murata; Ken Sato; Junko Kon; Hideaki Tomura; M Yanagita; Atsushi Kuwabara; Michio Ui; Fumikazu Okajima
Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions.
The Biochemical journal 2000;352 Pt 3():809-15.
2000: Qian Zhu; Kazuya Yamagata; L Yu; Hideaki Tomura; S Yamada; Qin Yang; Issei Yoshiuchi; S Sumi; Jun-ichiro Miyagawa; Jun Takeda; Toshiaki Hanafusa; Yuji Matsuzawa
Identification of missense mutations in the hepatocyte nuclear factor-3beta gene in Japanese subjects with late-onset Type II diabetes mellitus.
Diabetologia 2000;43(9):1197-200.
2000: Naoya Murata; Ken Sato; Junko Kon; Hideaki Tomura; Fumikazu Okajima
Quantitative measurement of sphingosine 1-phosphate by radioreceptor-binding assay.
Analytical biochemistry 2000;282(1):115-20.
2000: Hiroyuki Shimizu; Fumikazu Okajima; Takao Kimura; K Ohtani; Takahumi Tsuchiya; H Takahashi; Atsushi Kuwabara; Hideaki Tomura; Ken Sato; Masatomo Mori
Sphingosine 1-phosphate stimulates insulin secretion in HIT-T 15 cells and mouse islets.
Endocrine journal 2000;47(3):261-9.
2000: Y Aihara; H Mashima; H Onda; S Hisano; H Kasuya; T Hori; Satoko Yamada; Hideaki Tomura; Y Yamada; I Inoue; Itaru Kojima; Jun Takeda
Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter.
Journal of neurochemistry 2000;74(6):2622-5.
2000: Takao Kimura; Takashi Watanabe; Ken Sato; Junko Kon; Hideaki Tomura; Kenichi Tamama; Atsushi Kuwabara; Tsugiyasu Kanda; Isao Kobayashi; Hideo Ohta; Michio Ui; Fumikazu Okajima
Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3.
The Biochemical journal 2000;348 Pt 1():71-6.
2000: Yuji Yamazaki; Junko Kon; Ken Sato; Hideaki Tomura; M Sato; Takashi Yoneya; H Okazaki; Fumikazu Okajima; Hideo Ohta
Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway.
Biochemical and biophysical research communications 2000;268(2):583-9.
2000: Satoko Yamada; Q Zhu; Y Aihara; H Onda; Z Zhang; L Yu; L Jin; Y J Si; Hidekazu Nishigori; Hideaki Tomura; I Inoue; A Morikawa; Kazuya Yamagata; T Hanafusa; Yuji Matsuzawa; Jun Takeda
Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3 beta and mutation screening in Japanese subjects with maturity-onset diabetes of the young.
Diabetologia 2000;43(1):121-4.
1999: Junko Kon; Ken Sato; Takashi Watanabe; Hideaki Tomura; Atsushi Kuwabara; Takao Kimura; Kenichi Tamama; Tamotsu Ishizuka; Naoya Murata; Tsugiyasu Kanda; Isao Kobayashi; Hideo Ohta; Michio Ui; Fumikazu Okajima
Comparison of intrinsic activities of the putative sphingosine 1-phosphate receptor subtypes to regulate several signaling pathways in their cDNA-transfected Chinese hamster ovary cells.
The Journal of biological chemistry 1999;274(34):23940-7.
1999: Hideaki Tomura; Hidekazu Nishigori; K Sho; Kazuya Yamagata; I Inoue; Jun Takeda
Loss-of-function and dominant-negative mechanisms associated with hepatocyte nuclear factor-1beta mutations in familial type 2 diabetes mellitus.
The Journal of biological chemistry 1999;274(19):12975-8.
1999: Satoko Yamada; Hideaki Tomura; Hidekazu Nishigori; K Sho; Hiroyo Mabe; Noritaka Iwatani; T Takumi; Y Kito; N Moriya; K Muroya; Takeki Ogata; Kazumichi Onigata; A Morikawa; I Inoue; Jun Takeda
Identification of mutations in the hepatocyte nuclear factor-1alpha gene in Japanese subjects with early-onset NIDDM and functional analysis of the mutant proteins.
Diabetes 1999;48(3):645-8.
1999: Ken Sato; Junko Kon; Hideaki Tomura; M Osada; Naoya Murata; Atsushi Kuwabara; Takashi Watanabe; Hideo Ohta; Michio Ui; Fumikazu Okajima
Activation of phospholipase C-Ca2+ system by sphingosine 1-phosphate in CHO cells transfected with Edg-3, a putative lipid receptor.
FEBS letters 1999;443(1):25-30.
1999: Ken Sato; Hideaki Tomura; Y Igarashi; Michio Ui; Fumikazu Okajima
Possible involvement of cell surface receptors in sphingosine 1-phosphate-induced activation of extracellular signal-regulated kinase in C6 glioma cells.
Molecular pharmacology 1999;55(1):126-33.
1998: Ken Sato; Naoya Murata; Junko Kon; Hideaki Tomura; Hiromi Nochi; Koichi Tamoto; M Osada; Hideo Ohta; Yukiko Tokumitsu; Michio Ui; Fumikazu Okajima
Downregulation of mRNA expression of Edg-3, a putative sphingosine 1-phosphate receptor coupled to Ca2+ signaling, during differentiation of HL-60 leukemia cells.
Biochemical and biophysical research communications 1998;253(2):253-6.
1998: Fumikazu Okajima; Ken Sato; Hideaki Tomura; Atsushi Kuwabara; Hiromi Nochi; Koichi Tamoto; Yasuto Kondo; Yukiko Tokumitsu; Michio Ui
Stimulatory and inhibitory actions of lysophosphatidylcholine, depending on its fatty acid residue, on the phospholipase C/Ca2+ system in HL-60 leukaemia cells.
The Biochemical journal 1998;336 ( Pt 2)():491-500.
1998: Hidekazu Nishigori; Satoko Yamada; T Kohama; Hideaki Tomura; K Sho; Y Horikawa; G I Bell; Toshiyuki Takeuchi; Jun Takeda
Frameshift mutation, A263fsinsGG, in the hepatocyte nuclear factor-1beta gene associated with diabetes and renal dysfunction.
Diabetes 1998;47(8):1354-5.
1998: Hidekazu Nishigori; Satoko Yamada; Hideaki Tomura; A A Fernald; M M Le Beau; Toshiyuki Takeuchi; Jun Takeda
Identification and characterization of the gene encoding a second proteolipid subunit of human vacuolar H(+)-ATPase (ATP6F).
Genomics 1998;50(2):222-8.
1997: Ken Sato; Hideaki Tomura; Y Igarashi; Michio Ui; Fumikazu Okajima
Exogenous sphingosine 1-phosphate induces neurite retraction possibly through a cell surface receptor in PC12 cells.
Biochemical and biophysical research communications 1997;240(2):329-34.
1997: Hideaki Tomura; H Itoh; K Sho; Ken Sato; M Nagao; Michio Ui; Yasuto Kondo; Fumikazu Okajima
Betagamma subunits of pertussis toxin-sensitive G proteins mediate A1 adenosine receptor agonist-induced activation of phospholipase C in collaboration with thyrotropin. A novel stimulatory mechanism through the cross-talk of two types of receptors.
The Journal of biological chemistry 1997;272(37):23130-7.
1997: Takao Kimura; Fumikazu Okajima; T Kikuchi; Atsushi Kuwabara; Hideaki Tomura; K Sho; Isao Kobayashi; Yasuto Kondo
Inhibition of TSH-induced hydrogen peroxide production by TNF-alpha through a sphingomyelinase signaling pathway.
The American journal of physiology 1997;273(3 Pt 1):E639-43.
1997: Fumikazu Okajima; Hideaki Tomura; K Sho; Takao Kimura; Ken Sato; Dong-Soon Im; M Akbar; Yasuto Kondo
Sphingosine 1-phosphate stimulates hydrogen peroxide generation through activation of phospholipase C-Ca2+ system in FRTL-5 thyroid cells: possible involvement of guanosine triphosphate-binding proteins in the lipid signaling.
Endocrinology 1997;138(1):220-9.
1996: Fumikazu Okajima; Hideaki Tomura; K Sho; Hiromi Nochi; Koichi Tamoto; Yasuto Kondo
Involvement of pertussis toxin-sensitive GTP-binding proteins in sphingosine 1-phosphate-induced activation of phospholipase C-Ca2+ system in HL60 leukemia cells.
FEBS letters 1996;379(3):260-4.
1995: Fumikazu Okajima; Hideaki Tomura; K Sho; M Akbar; M A Majid; Yasuto Kondo
Intracellular cross-talk between thyrotropin receptor and A1 adenosine receptor in regulation of phospholipase C and adenylate cyclase in COS-7 cells transfected with their receptor genes.
The Biochemical journal 1995;306 ( Pt 3)():709-15.
1994: Fumikazu Okajima; M Akbar; M Abdul Majid; K Sho; Hideaki Tomura; Yasuto Kondo
Genistein, an inhibitor of protein tyrosine kinase, is also a competitive antagonist for P1-purinergic (adenosine) receptor in FRTL-5 thyroid cells.
Biochemical and biophysical research communications 1994;203(3):1488-95.
1994: M Akbar; Fumikazu Okajima; Hideaki Tomura; M A Majid; Y Yamada; Susumu Seino; Yasuto Kondo
Phospholipase C activation and Ca2+ mobilization by cloned human somatostatin receptor subtypes 1-5, in transfected COS-7 cells.
FEBS letters 1994;348(2):192-6.
1994: M Akbar; Fumikazu Okajima; Hideaki Tomura; S Shimegi; Yasuto Kondo
A single species of A1 adenosine receptor expressed in Chinese hamster ovary cells not only inhibits cAMP accumulation but also stimulates phospholipase C and arachidonate release.
Molecular pharmacology 1994;45(5):1036-42.
1994: Hideaki Tomura; Fumikazu Okajima; M Akbar; M Abdul Majid; K Sho; Yasuto Kondo
Transfected human somatostatin receptor type 2, SSTR2, not only inhibits adenylate cyclase but also stimulates phospholipase C and Ca2+ mobilization.
Biochemical and biophysical research communications 1994;200(2):986-92.
1993: Fumikazu Okajima; Hideaki Tomura; Yasuto Kondo
Enkephalin activates the phospholipase C/Ca2+ system through cross-talk between opioid receptors and P2-purinergic or bradykinin receptors in NG 108-15 cells. A permissive role for pertussis toxin-sensitive G-proteins.
The Biochemical journal 1993;290 ( Pt 1)():241-7.
1992: Hideaki Tomura; Fumikazu Okajima; Yasuto Kondo
Enkephalin induces Ca2+ mobilization in single cells of bradykinin-sensitized differentiated neuroblastoma hybridoma (NG108-15) cells.
Neuroscience letters 1992;148(1-2):93-6.
1992: Hideaki Tomura; Fumikazu Okajima; Yasuto Kondo
Discrimination between two types of P2 purinoceptors by suramin in rat hepatocytes.
European journal of pharmacology 1992;226(4):363-5.
1991: Y Hirano; Fumikazu Okajima; Hideaki Tomura; M A Majid; Toshiyuki Takeuchi; Yasuto Kondo
Change of intracellular calcium of neural cells induced by extracellular ATP.
FEBS letters 1991;284(2):235-7.