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Massimo Tonacchera

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Massimo Tonacchera; Fabrizio Aghini-Lombardi; Patrizia Agretti; Giuseppina de Marco; Melissa de Servi; Antonio Dimida; Eleonora Ferrarini; Monica Frigeri; Lucia Grasso; Pierdomenico Perata; Paolo Piaggi; Aldo Pinchera; Paolo Vitti
Iodine fortification of vegetables improves human iodine nutrition: in vivo evidence for a new model of iodine prophylaxis.
F Aghini Lombardi; Lucia Antonangeli; Emilio Fiore; M Frigeri; Lucia Grasso; Lucia Montanelli; Aldo Pinchera; A M Provenzale; Teresa Rago; Massimo Tonacchera; Paolo Vitti
The effect of voluntary iodine prophylaxis in a small rural community: the Pescopagano survey 15 years later.
Manuela Cerbone; Giuseppina De Marco; Nicola Improda; Claudio Pignata; Francesca Santamaria; Massimo Tonacchera; Patrizia Agretti; Mariacarolina Salerno
Non-autoimmune subclinical hypothyroidism due to a mutation in TSH receptor: report on two brothers.

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2013: Massimo Tonacchera; Fabrizio Aghini-Lombardi; Patrizia Agretti; Giuseppina de Marco; Melissa de Servi; Antonio Dimida; Eleonora Ferrarini; Monica Frigeri; Lucia Grasso; Pierdomenico Perata; Paolo Piaggi; Aldo Pinchera; Paolo Vitti
Iodine fortification of vegetables improves human iodine nutrition: in vivo evidence for a new model of iodine prophylaxis.
The Journal of clinical endocrinology and metabolism 2013;98(4):E694-7.
2013: F Aghini Lombardi; Lucia Antonangeli; Emilio Fiore; M Frigeri; Lucia Grasso; Lucia Montanelli; Aldo Pinchera; A M Provenzale; Teresa Rago; Massimo Tonacchera; Paolo Vitti
The effect of voluntary iodine prophylaxis in a small rural community: the Pescopagano survey 15 years later.
The Journal of clinical endocrinology and metabolism 2013;98(3):1031-9.
2013: Manuela Cerbone; Giuseppina De Marco; Nicola Improda; Claudio Pignata; Francesca Santamaria; Massimo Tonacchera; Patrizia Agretti; Mariacarolina Salerno
Non-autoimmune subclinical hypothyroidism due to a mutation in TSH receptor: report on two brothers.
Italian journal of pediatrics 2013;39():5.
2013: Eleonora Ferrarini; Franca Fruzzetti; Elena Gianetti; Aldo Pinchera; Enrico Pucci; Laura Russo; Paolo Simi; Tommaso Simoncini; Patrizia Agretti; Fulvia Baldinotti; Elena Benelli; Giuseppina de Marco; Antonio Dimida; Paolo Vitti; Massimo Tonacchera
Clinical characteristics and genetic analysis in women with premature ovarian insufficiency.
Maturitas 2013;74(1):61-7.
2012: Patrizia Agretti; Antonio Candelieri; Giuseppina de Marco; Giancarlo Di Coscio; Antonio Dimida; Eleonora Ferrarini; Angelo Molinaro; Filippo Niccolai; Aldo Pinchera; Teresa Rago; Paolo Vitti; Massimo Tonacchera
MicroRNA expression profile helps to distinguish benign nodules from papillary thyroid carcinomas starting from cells of fine-needle aspiration.
European journal of endocrinology / European Federation of Endocrine Societies 2012;167(3):393-400.
2012: Massimo Tonacchera; Patrizia Agretti; Fulvio Basolo; A Candelieri; D Conforti; Giuseppina de Marco; Giancarlo Di Coscio; Pietro Iacconi; Paolo Miccoli; A Molinaro; R Musmanno; F Niccolai; Aldo Pinchera; Teresa Rago; M Scutari; Paolo Vitti
Genetic markers to discriminate benign and malignant thyroid nodules with undetermined cytology in an area of borderline iodine deficiency.
Journal of endocrinological investigation 2012;35(8):754-9.
2012: Patrizia Agretti; Martina Biagioni; Valentino Cherubini; Giuseppina de Marco; Antonio Iannilli; Marco Marigliano; Aldo Pinchera; Paolo Vitti; Massimo Tonacchera
Sporadic congenital nonautoimmune hyperthyroidism caused by P639S mutation in thyrotropin receptor gene.
European journal of pediatrics 2012;171(7):1133-7.
2012: Laura Bazzichi; Angela Dardano; Francesca De Feo; Melissa de Servi; M Doveri; Camillo Giacomelli; Gabriele Massimetti; Fabio Monzani; Alessandra Rossi; F Santini; S Tognini; Massimo Tonacchera; C Zirafa; Stefano Bombardieri
Thyroid autoimmunity may represent a predisposition for the development of fibromyalgia?
Rheumatology international 2012;32(2):335-41.
2012: Martina Landini; Aldo Pinchera; Massimo Tonacchera; Paolo Vitti; Patrizia Agretti; Amedeo Alpi; Antonio Dimida; Silvia Gonzali; Claudia Kiferle; Pierdomenico Perata
Metabolic engineering of the iodine content in Arabidopsis.
Scientific reports 2012;2():338.
2011: Giuseppina de Marco; Melissa de Servi; Caterina di Cosmo; Antonio Dimida; Eleonora Ferrarini; Andrea Claudia Freitas Ferreira; Angelo Molinaro; Lucia Montanelli; Aldo Pinchera; Patrizia Agretti; Brunella Bagattini; Federica Brozzi; Claudia Ceccarelli; Paolo Vitti; Massimo Tonacchera
Identification and functional analysis of novel dual oxidase 2 (DUOX2) mutations in children with congenital or subclinical hypothyroidism.
The Journal of clinical endocrinology and metabolism 2011;96(8):E1335-9.
2011: Patrizia Agretti; Grazia Chiellini; Giuseppina de Marco; Lucia Grasso; Maja Marchini; Aldo Pinchera; Andrea Raffaelli; Laura Russo; Alessandro Saba; Thomas S Scanlan; Paolo Vitti; Riccardo Zucchi; Massimo Tonacchera
3-Iodothyronamine metabolism and functional effects in FRTL5 thyroid cells.
Journal of molecular endocrinology 2011;47(1):23-32.
2011: Claudia Ceccarelli; Salvatore Mazzeo; Aldo Pinchera; Pierina Santini; Massimo Tonacchera; Lucia Antonangeli; Walter Bencivelli; Francesca Bianchi; Federica Brozzi; Paolo Vitti
Radioiodine 131I treatment for large nodular goiter: recombinant human thyrotropin allows the reduction of radioiodine 131I activity to be administered in patients with low uptake.
Thyroid : official journal of the American Thyroid Association 2011;21(7):759-64.
2011: Antonio Dimida; Eleonora Ferrarini; Patrizia Agretti; Giuseppina de Marco; Lucia Grasso; M Martinelli; I Longo; D Giulietti; A Ricci; M Galimberti; B Siervo; G Licitra; F Francia; Aldo Pinchera; Paolo Vitti; Massimo Tonacchera
Electric and magnetic fields do not modify the biochemical properties of FRTL-5 cells.
Journal of endocrinological investigation 2011;34(3):185-9.
2011: Patrizia Agretti; Antonio Dimida; Giuseppina de Marco; Eleonora Ferrarini; J C Rodrìguez Gonzàlez; Ferruccio Santini; Paolo Vitti; Aldo Pinchera; Massimo Tonacchera
Study of potential inhibitors of thyroid iodide uptake by using CHO cells stably expressing the human sodium/iodide symporter (hNIS) protein.
Journal of endocrinological investigation 2011;34(3):170-4.
2010: Patrizia Agretti; Giuseppina de Marco; D Sansone; Corrado Betterle; G Coco; Antonio Dimida; Eleonora Ferrarini; Aldo Pinchera; Paolo Vitti; Massimo Tonacchera
Patients affected by vitiligo and autoimmune diseases do not show antibodies interfering with the activity of the melanocortin 1 receptor.
Journal of endocrinological investigation 2010;33(11):784-8.
2010: Alessandro Saba; Grazia Chiellini; Sabina Frascarelli; Maja Marchini; Sandra Ghelardoni; Andrea Raffaelli; Massimo Tonacchera; Paolo Vitti; Thomas S Scanlan; Riccardo Zucchi
Tissue distribution and cardiac metabolism of 3-iodothyronamine.
Endocrinology 2010;151(10):5063-73.
2010: Lucia Montanelli; Massimo Tonacchera
Genetics and phenomics of hypothyroidism and thyroid dys- and agenesis due to PAX8 and TTF1 mutations.
Molecular and cellular endocrinology 2010;322(1-2):64-71.
2010: Massimo Tonacchera; Aldo Pinchera; Paolo Vitti
Assessment of nodular goitre.
Best practice & research. Clinical endocrinology & metabolism 2010;24(1):51-61.
2009: Lucia Montanelli; Patrizia Agretti; Giuseppina de Marco; Brunella Bagattini; Claudia Ceccarelli; Federica Brozzi; Teresa Lettiero; Manuela Cerbone; Paolo Vitti; Mariacarolina Salerno; Aldo Pinchera; Massimo Tonacchera
Congenital hypothyroidism and late-onset goiter: identification and characterization of a novel mutation in the sodium/iodide symporter of the proband and family members.
Thyroid : official journal of the American Thyroid Association 2009;19(12):1419-25.
2009: Mario Rossi; Antonio Dimida; Eleonora Ferrarini; Elena Silvano; Giuseppina de Marco; Patrizia Agretti; Gabriella Aloisi; Tommaso Simoncini; Lorenzo Di Bari; Massimo Tonacchera; Filippo S Giorgi; Roberto Maggio
Presence of a putative steroidal allosteric site on glycoprotein hormone receptors.
European journal of pharmacology 2009;623(1-3):155-9.
2009: Annalisa Nicoletti; Milva Bal; Giuseppina De Marco; Lilia Baldazzi; Patrizia Agretti; Soara Menabò; Elisa Ballarini; Alessandro Cicognani; Massimo Tonacchera; Alessandra Cassio
Thyrotropin-stimulating hormone receptor gene analysis in pediatric patients with non-autoimmune subclinical hypothyroidism.
The Journal of clinical endocrinology and metabolism 2009;94(11):4187-94.
2009: Massimo Tonacchera; Giuseppina de Marco; Patrizia Agretti; Lucia Montanelli; Caterina di Cosmo; Andrea Claudia Freitas Ferreira; Antonio Dimida; Eleonora Ferrarini; Helton Estrela Ramos; Claudia Ceccarelli; Federica Brozzi; Aldo Pinchera; Paolo Vitti
Identification and functional studies of two new dual-oxidase 2 (DUOX2) mutations in a child with congenital hypothyroidism and a eutopic normal-size thyroid gland.
The Journal of clinical endocrinology and metabolism 2009;94(11):4309-14.
2009: Giuseppina de Marco; Patrizia Agretti; Marta Camilot; Francesca Teofoli; Luciano Tatò; Paolo Vitti; Aldo Pinchera; Massimo Tonacchera
Functional studies of new TSH receptor (TSHr) mutations identified in patients affected by hypothyroidism or isolated hyperthyrotrophinaemia.
Clinical endocrinology 2009;70(2):335-8.
2008: Salvatore Benvenga; Arash Ordookhani; Elizabeth N Pearce; Massimo Tonacchera; Fereidoun Azizi; Lewis E Braverman
Detection of circulating autoantibodies against thyroid hormones in an infant with permanent congenital hypothyroidism and her twin with transient congenital hypothyroidism: possible contribution of thyroid hormone autoantibodies to neonatal and infant hypothyroidism.
Journal of pediatric endocrinology & metabolism : JPEM 2008;21(10):1011-20.
2008: Diego Diez; Carmen Grijota-Martinez; Patrizia Agretti; Giuseppina de Marco; Massimo Tonacchera; Aldo Pinchera; Gabriella Morreale de Escobar; Juan Bernal; Beatriz Morte
Thyroid hormone action in the adult brain: gene expression profiling of the effects of single and multiple doses of triiodo-L-thyronine in the rat striatum.
Endocrinology 2008;149(8):3989-4000.
2008: Francesca Porchia; Mara Papucci; Claudia Gargini; Antonella Asta; Giuseppina de Marco; Patrizia Agretti; Massimo Tonacchera; Maria R Mazzoni
Endothelin-1 up-regulates p115RhoGEF in embryonic rat cardiomyocytes during the hypertrophic response.
Journal of receptor and signal transduction research 2008;28(3):265-83.
2007: Massimo Tonacchera; Caterina di Cosmo; Giuseppina de Marco; Patrizia Agretti; Mariaelena Banco; Anna Perri; Elena Gianetti; Lucia Montanelli; Paolo Vitti; Aldo Pinchera
Identification of TSH receptor mutations in three families with resistance to TSH.
Clinical endocrinology 2007;67(5):712-8.
2007: Patrizia Agretti; Giuseppina de Marco; Alessandra Capodanno; Eleonora Ferrarini; Antonio Dimida; Daniela Sansone; Paola Collecchi; Aldo Pinchera; Paolo Vitti; Massimo Tonacchera
A fast method to detect cell surface expression of thyrotropin receptor (TSHr): the microchip flow cytometry analysis.
Thyroid : official journal of the American Thyroid Association 2007;17(9):861-8.
2007: Massimo Tonacchera; Mariaelena Banco; Lucia Montanelli; Caterina di Cosmo; Patrizia Agretti; Giuseppina de Marco; Eleonora Ferrarini; Arash Ordookhani; Anna Perri; Luca Chiovato; Ferruccio Santini; Paolo Vitti; Aldo Pinchera
Genetic analysis of the PAX8 gene in children with congenital hypothyroidism and dysgenetic or eutopic thyroid glands: identification of a novel sequence variant.
Clinical endocrinology 2007;67(1):34-40.
2007: Patrizia Agretti; Giuseppina de Marco; Aldo Pinchera; Paolo Vitti; J Bernal; Massimo Tonacchera
Ras homolog enriched in striatum inhibits the functional activity of wild type thyrotropin, follicle-stimulating hormone, luteinizing hormone receptors and activating thyrotropin receptor mutations by altering their expression in COS-7 cells.
Journal of endocrinological investigation 2007;30(4):279-84.
2007: Paolo Viacava; Guido Bocci; Massimo Tonacchera; Giovanni Fanelli; Melissa DeServi; Patrizia Agretti; Edoardo Berti; Orlando Goletti; Paolo Aretini; Maria Letizia Resta; Generoso Bevilacqua; Antonio Giuseppe Naccarato
Markers of cell proliferation, apoptosis, and angiogenesis in thyroid adenomas: a comparative immunohistochemical and genetic investigation of functioning and nonfunctioning nodules.
Thyroid : official journal of the American Thyroid Association 2007;17(3):191-7.
2007: Mario Rossi; Antonio Dimida; Maria Teresa Dell'anno; Maria Letizia Trincavelli; Patrizia Agretti; Filippo S Giorgi; Giovanni U Corsini; Aldo Pinchera; Paolo Vitti; Massimo Tonacchera; Roberto Maggio
The thyroid disruptor 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane appears to be an uncompetitive inverse agonist for the thyrotropin receptor.
The Journal of pharmacology and experimental therapeutics 2007;320(1):465-74.
2006: Francesco Orio; Eleonora Ferrarini; Teresa Cascella; Antonio Dimida; Stefano Palomba; Elena Gianetti; Annamaria Colao; Patrizia Agretti; Paolo Vitti; Gaetano Lombardi; Aldo Pinchera; Massimo Tonacchera
Genetic analysis of the follicle stimulating hormone receptor gene in women with polycystic ovary syndrome.
Journal of endocrinological investigation 2006;29(11):975-82.
2006: Massimo Tonacchera; Eleonora Ferrarini; Antonio Dimida; Patrizia Agretti; Giuseppina de Marco; Aldo Pinchera; J Sanders; M Evans; T Richards; J Furmaniak; Bernard Rees Smith
Effects of a thyroid-stimulating human monoclonal autoantibody (M22) on functional activity of LH and FSH receptors.
Thyroid : official journal of the American Thyroid Association 2006;16(11):1085-9.
2006: Caterina di Cosmo; Giovanni Fanelli; Massimo Tonacchera; Eleonora Ferrarini; Antonio Dimida; Patrizia Agretti; Giuseppina de Marco; Paolo Vitti; Aldo Pinchera; G Bevilacqua; Antonio Giuseppe Naccarato; Paolo Viacava
The sodium-iodide symporter expression in placental tissue at different gestational age: an immunohistochemical study.
Clinical endocrinology 2006;65(4):544-8.
2006: Simone Martinelli; Claudio Carta; Elisabetta Flex; Francesco Binni; Emanuela Lucci Cordisco; Sonia Moretti; Efisio Puxeddu; Massimo Tonacchera; Aldo Pinchera; Heather P McDowell; Carlo Dominici; Angelo Rosolen; Concezio Di Rocco; Riccardo Riccardi; Paolo Celli; Mauro Picardo; Maurizio Genuardi; Paola Grammatico; Mariella Sorcini; Marco Tartaglia
Activating PTPN11 mutations play a minor role in pediatric and adult solid tumors.
Cancer genetics and cytogenetics 2006;166(2):124-9.
2006: Fausto Bogazzi; Francesco Raggi; Federica Ultimieri; Dania Russo; Chiara Cosci; Paolo Cecchetti; Enrica Dell'Unto; Chiara Sardella; Massimo Tonacchera; Paolo Vitti; Luca Benzi; Luigi Bartalena; Enio Martino
Uptake of amiodarone by thyroidal and non-thyroidal cell lines.
Journal of endocrinological investigation 2006;29(1):61-6.
2005: Patrizia Agretti; Giuseppina de Marco; Melissa de Servi; Claudio Marcocci; Paolo Vitti; Aldo Pinchera; Massimo Tonacchera
Evidence for protein and mRNA TSHr expression in fibroblasts from patients with thyroid-associated ophthalmopathy (TAO) after adipocytic differentiation.
European journal of endocrinology / European Federation of Endocrine Societies 2005;152(5):777-84.
2004: Massimo Tonacchera; Aldo Pinchera; Antonio Dimida; Eleonora Ferrarini; Patrizia Agretti; Paolo Vitti; Ferruccio Santini; Kenny Crump; John Gibbs
Relative potencies and additivity of perchlorate, thiocyanate, nitrate, and iodide on the inhibition of radioactive iodide uptake by the human sodium iodide symporter.
Thyroid : official journal of the American Thyroid Association 2004;14(12):1012-9.
2004: Massimo Tonacchera; Anna Perri; Giuseppina de Marco; Patrizia Agretti; Mariaelena Banco; Caterina di Cosmo; Lucia Grasso; Paolo Vitti; Luca Chiovato; Aldo Pinchera
Low prevalence of thyrotropin receptor mutations in a large series of subjects with sporadic and familial nonautoimmune subclinical hypothyroidism.
The Journal of clinical endocrinology and metabolism 2004;89(11):5787-93.
2004: Paola Fierabracci; Aldo Pinchera; Massimo Tonacchera; Patrizia Agretti; Giuseppina de Marco; S Albertini; G Conforti; Ettore Seregni; Roberto Agresti; Lucia Grasso; Claudio Giani
Absence of interference of serum IgGs from patients with breast cancer and thyroid autoimmunity on the function of human iodide symporter gene stably transfected in CHO cells.
Journal of endocrinological investigation 2004;27(9):862-5.
2004: Massimo Tonacchera; Eleonora Ferrarini; Antonio Dimida; Patrizia Agretti; Giuseppina de Marco; Melissa de Servi; Elena Gianetti; Luca Chiovato; Enrico Pucci; Chiara Dal Pra; Corrado Betterle; Fabrizio Aghini-Lombardi; Paolo Vitti; Aldo Pinchera
Gonadotrophin receptor blocking antibodies measured by the use of cell lines stably expressing human gonadotrophin receptors are not detectable in women with 46,XX premature ovarian failure.
Clinical endocrinology 2004;61(3):376-81.
2004: Massimo Tonacchera; Mariaelena Banco; Paola Lapi; Caterina di Cosmo; Anna Perri; Lucia Montanelli; Lidia Moschini; Gianluca Gatti; Daniele Gandini; Alessandro Massei; Patrizia Agretti; Giuseppina de Marco; Paolo Vitti; Luca Chiovato; Aldo Pinchera
Genetic analysis of TTF-2 gene in children with congenital hypothyroidism and cleft palate, congenital hypothyroidism, or isolated cleft palate.
Thyroid : official journal of the American Thyroid Association 2004;14(8):584-8.
2004: Massimo Tonacchera; Paolo Viacava; Giovanni Fanelli; Patrizia Agretti; Giuseppina de Marco; Melissa de Servi; Caterina di Cosmo; Luca Chiovato; Aldo Pinchera; Paolo Vitti
The sodium-iodide symporter protein is always present at a low expression and confined to the cell membrane in nonfunctioning nonadenomatous nodules of toxic nodular goitre.
Clinical endocrinology 2004;61(1):40-5.
2004: Massimo Tonacchera; Eleonora Ferrarini; Antonio Dimida; Patrizia Agretti; Giuseppina de Marco; Melissa de Servi; Luca Chiovato; Filomena Cetani; Paolo Vitti; Aldo Pinchera
TSH receptor antibodies do not alter the function of gonadotropin receptors stably expressed in eukaryotic cells.
European journal of endocrinology / European Federation of Endocrine Societies 2004;150(3):381-7.
2004: Ferruccio Santini; Margherita Maffei; Giovanni Ceccarini; Caterina Pelosini; Giovanna Scartabelli; Veronica Rosellini; Chiara Chiellini; Alessandro Marsili; Simonetta Lisi; Massimo Tonacchera; Patrizia Agretti; Luca Chiovato; Claudia Mammoli; Paolo Vitti; Aldo Pinchera
Genetic screening for melanocortin-4 receptor mutations in a cohort of Italian obese patients: description and functional characterization of a novel mutation.
The Journal of clinical endocrinology and metabolism 2004;89(2):904-8.
2003: Massimo Tonacchera; Anna Perri; Giuseppina de Marco; Patrizia Agretti; Lucia Montanelli; Mariaelena Banco; Andrea Corrias; Jaele Bellone; M T Tosi; Paolo Vitti; Enio Martino; Aldo Pinchera; Luca Chiovato
TSH receptor and Gs(alpha) genetic analysis in children with Down's syndrome and subclinical hypothyroidism.
Journal of endocrinological investigation 2003;26(10):997-1000.
2003: Ferruccio Santini; Paolo Vitti; Giovanni Ceccarini; Claudia Mammoli; Veronica Rosellini; Caterina Pelosini; Alessandro Marsili; Massimo Tonacchera; Patrizia Agretti; Tatiana Santoni; Luca Chiovato; Aldo Pinchera
In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity.
Journal of endocrinological investigation 2003;26(10):950-5.
2003: Massimo Tonacchera; Patrizia Agretti; Giuseppina de Marco; Rossella Elisei; Anna Perri; Elena Ambrogini; Melissa de Servi; Claudia Ceccarelli; Paolo Viacava; Samuel Refetoff; Claudio Panunzi; Maria Luisa Manca Bitti; Paolo Vitti; Luca Chiovato; Aldo Pinchera
Congenital hypothyroidism due to a new deletion in the sodium/iodide symporter protein.
Clinical endocrinology 2003;59(4):500-6.
2003: Patrizia Agretti; Giuseppina de Marco; Paola Collecchi; Luca Chiovato; Paolo Vitti; Aldo Pinchera; Massimo Tonacchera
Proper targeting and activity of a nonfunctioning thyroid-stimulating hormone receptor (TSHr) combining an inactivating and activating TSHr mutation in one receptor.
European journal of biochemistry / FEBS 2003;270(18):3839-47.
2003: Paola Luciani; Lisa Buci; Barbara Conforti; Massimo Tonacchera; Patrizia Agretti; Rossella Elisei; Agnese Vivaldi; Federica Cioppi; Giancarlo Biliotti; Gianpiero Manca; Paolo Vitti; Mario Serio; Alessandro Peri
Expression of cAMP response element-binding protein and sodium iodide symporter in benign non-functioning and malignant thyroid tumours.
European journal of endocrinology / European Federation of Endocrine Societies 2003;148(5):579-86.
2003: Filomena Cetani; Elena Pardi; Simona Borsari; Massimo Tonacchera; Eugenia Morabito; Aldo Pinchera; Claudio Marcocci; Giada Dipollina
Two Italian kindreds with familial hypocalciuric hypercalcaemia caused by loss-of-function mutations in the calcium-sensing receptor (CaR) gene: functional characterization of a novel CaR missense mutation.
Clinical endocrinology 2003;58(2):199-206.
2003: Massimo Tonacchera; Paolo Vitti; Melissa de Servi; Patrizia Agretti; Giuseppina de Marco; Luca Chiovato; Aldo Pinchera
Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis.
Journal of endocrinological investigation 2003;26(2 Suppl):2-6.
2002: Patrizia Agretti; Luca Chiovato; Giuseppina de Marco; Claudio Marcocci; Barbara Mazzi; Stefano Sellari-Franceschini; Paolo Vitti; Aldo Pinchera; Massimo Tonacchera
Real-time PCR provides evidence for thyrotropin receptor mRNA expression in orbital as well as in extraorbital tissues.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(6):733-9.
2002: Paola Romagnani; Mario Rotondi; Elena Lazzeri; Laura Lasagni; Michela Francalanci; Andrea Buonamano; Stefano Milani; Paolo Vitti; Luca Chiovato; Massimo Tonacchera; Antonio Bellastella; Mario Serio
Expression of IP-10/CXCL10 and MIG/CXCL9 in the thyroid and increased levels of IP-10/CXCL10 in the serum of patients with recent-onset Graves' disease.
The American journal of pathology 2002;161(1):195-206.
2002: Alessandro Peri; Paola Luciani; Massimo Tonacchera; Patrizia Agretti; Silvana Baglioni-Peri; Lisa Buci; Barbara Conforti; Federica Cioppi; Giancarlo Biliotti; Mario Serio; Paolo Vitti; Luca Chiovato
Expression of cAMP-responsive element binding protein and inducible cAMP early repressor in hyperfunctioning thyroid adenomas.
European journal of endocrinology / European Federation of Endocrine Societies 2002;146(6):759-66.
2002: Paolo Vitti; Teresa Rago; Massimo Tonacchera; Aldo Pinchera
Toxic multinodular goiter in the elderly.
Journal of endocrinological investigation 2002;25(10 Suppl):16-8.
2002: Massimo Tonacchera; Paolo Viacava; Patrizia Agretti; Giuseppina de Marco; Anna Perri; Caterina di Cosmo; Melissa de Servi; Paolo Miccoli; Francesco Lippi; Antonio Giuseppe Naccarato; Aldo Pinchera; Luca Chiovato; Paolo Vitti
Benign nonfunctioning thyroid adenomas are characterized by a defective targeting to cell membrane or a reduced expression of the sodium iodide symporter protein.
The Journal of clinical endocrinology and metabolism 2002;87(1):352-7.
2001: Massimo Tonacchera; Patrizia Agretti; Giuseppina de Marco; Anna Perri; Aldo Pinchera; Paolo Vitti; Luca Chiovato
Thyroid resistance to TSH complicated by autoimmune thyroiditis.
The Journal of clinical endocrinology and metabolism 2001;86(9):4543-6.
2001: Massimo Tonacchera; Patrizia Agretti; Giovanni Ceccarini; R Lenza; Samuel Refetoff; Ferruccio Santini; Aldo Pinchera; Luca Chiovato; Paolo Vitti
Autoantibodies from patients with autoimmune thyroid disease do not interfere with the activity of the human iodide symporter gene stably transfected in CHO cells.
European journal of endocrinology / European Federation of Endocrine Societies 2001;144(6):611-8.
2000: Massimo Tonacchera; Patrizia Agretti; Veronica Rosellini; Giovanni Ceccarini; Anna Perri; M Zampolli; R Longhi; D Larizza; Aldo Pinchera; Paolo Vitti; Luca Chiovato
Sporadic nonautoimmune congenital hyperthyroidism due to a strong activating mutation of the thyrotropin receptor gene.
Thyroid : official journal of the American Thyroid Association 2000;10(10):859-63.
2000: Massimo Tonacchera; Patrizia Agretti; Luca Chiovato; Veronica Rosellini; Giovanni Ceccarini; Anna Perri; Paolo Viacava; Antonio Giuseppe Naccarato; Paolo Miccoli; Aldo Pinchera; Paolo Vitti
Activating thyrotropin receptor mutations are present in nonadenomatous hyperfunctioning nodules of toxic or autonomous multinodular goiter.
The Journal of clinical endocrinology and metabolism 2000;85(6):2270-4.
2000: Massimo Tonacchera; Patrizia Agretti; Aldo Pinchera; Veronica Rosellini; Anna Perri; Paola Collecchi; Paolo Vitti; Luca Chiovato
Congenital hypothyroidism with impaired thyroid response to thyrotropin (TSH) and absent circulating thyroglobulin: evidence for a new inactivating mutation of the TSH receptor gene.
The Journal of clinical endocrinology and metabolism 2000;85(3):1001-8.
1999: Massimo Tonacchera; Paolo Vitti; Patrizia Agretti; Giovanni Ceccarini; Anna Perri; Rossana Cavaliere; Barbara Mazzi; Antonio Giuseppe Naccarato; Paolo Viacava; Paolo Miccoli; Aldo Pinchera; Luca Chiovato
Functioning and nonfunctioning thyroid adenomas involve different molecular pathogenetic mechanisms.
The Journal of clinical endocrinology and metabolism 1999;84(11):4155-8.
1999: Filomena Cetani; Massimo Tonacchera; Aldo Pinchera; Renata Barsacchi; Fulvio Basolo; Paolo Miccoli; Furio Pacini
Genetic analysis of the TSH receptor gene in differentiated human thyroid carcinomas.
Journal of endocrinological investigation 1999;22(4):273-8.
1998: Patrice Rodien; Filomena Cetani; Sabine Costagliola; Massimo Tonacchera; Laurence Duprez; T Minegishi; Cédric Govaerts; Gilbert Vassart
Evidences for an allelic variant of the human LC/CG receptor rather than a gene duplication: functional comparison of wild-type and variant receptors.
The Journal of clinical endocrinology and metabolism 1998;83(12):4431-4.
1998: Massimo Tonacchera; Paolo Vitti; Patrizia Agretti; B Giulianetti; Barbara Mazzi; Rossana Cavaliere; Giovanni Ceccarini; Emilio Fiore; Paolo Viacava; Antonio Giuseppe Naccarato; Aldo Pinchera; Luca Chiovato
Activating thyrotropin receptor mutations in histologically heterogeneous hyperfunctioning nodules of multinodular goiter.
Thyroid : official journal of the American Thyroid Association 1998;8(7):559-64.
1998: Massimo Tonacchera; Luca Chiovato; Aldo Pinchera; Patrizia Agretti; Emilio Fiore; Filomena Cetani; Roberto Rocchi; Paolo Viacava; Paolo Miccoli; Paolo Vitti
Hyperfunctioning thyroid nodules in toxic multinodular goiter share activating thyrotropin receptor mutations with solitary toxic adenoma.
The Journal of clinical endocrinology and metabolism 1998;83(2):492-8.
1996: Massimo Tonacchera; Filomena Cetani; Jasmine Parma; Jacqueline Van Sande; Gilbert Vassart; J Dumont
Oncogenic mutations in thyroid adenoma: methodological criteria.
European journal of endocrinology / European Federation of Endocrine Societies 1996;135(4):444-6.
1996: L Alcalde; Massimo Tonacchera; Sabine Costagliola; Dolores Jaraquemada; Ricardo Pujol Borrell; M Ludgate
Cloning of candidate autoantigen carboxypeptidase H from a human islet library: sequence identity with human brain CPH.
Journal of autoimmunity 1996;9(4):525-8.
1996: Massimo Tonacchera; Jacqueline Van Sande; Jasmine Parma; Laurence Duprez; Filomena Cetani; Sabine Costagliola; Jacques E Dumont; Gilbert Vassart
TSH receptor and disease.
Clinical endocrinology 1996;44(6):621-33.
1996: Massimo Tonacchera; Filomena Cetani; Sabine Costagliola; Jacqueline Van Sande; S Refetoff; Gilbert Vassart
Functional characteristics of a variant thyrotropin receptor.
European journal of biochemistry / FEBS 1996;238(2):490-4.
1996: Luca Chiovato; D Larizza; G Bendinelli; Massimo Tonacchera; M Marinó; Claudia Mammoli; R Lorini; F Severi; Aldo Pinchera
Autoimmune hypothyroidism and hyperthyroidism in patients with Turner's syndrome.
European journal of endocrinology / European Federation of Endocrine Societies 1996;134(5):568-75.
1996: Massimo Tonacchera; Jacqueline Van Sande; Filomena Cetani; S Swillens; C Schvartz; P Winiszewski; L Portmann; Jacques E Dumont; Gilbert Vassart; Jasmine Parma
Functional characteristics of three new germline mutations of the thyrotropin receptor gene causing autosomal dominant toxic thyroid hyperplasia.
The Journal of clinical endocrinology and metabolism 1996;81(2):547-54.
1996: Filomena Cetani; Massimo Tonacchera; Gilbert Vassart
Differential effects of NaCl concentration on the constitutive activity of the thyrotropin and the luteinizing hormone/chorionic gonadotropin receptors.
FEBS letters 1996;378(1):27-31.
1996: Gilbert Vassart; Jacqueline Van Sande; Jasmine Parma; Massimo Tonacchera; Laurence Duprez; S Swillens; J Dumont
Activating mutations of the TSH receptor gene cause thyroid diseases.
Annales d'endocrinologie 1996;57(1):50-4.
1996: Massimo Tonacchera; Sabine Costagliola; Filomena Cetani; J Ducobu; P Stordeur; Gilbert Vassart; Marian Ludgate
Patient with monoclonal gammopathy, thyrotoxicosis, pretibial myxedema and thyroid-associated ophthalmopathy; demonstration of direct binding of autoantibodies to the thyrotropin receptor.
European journal of endocrinology / European Federation of Endocrine Societies 1996;134(1):97-103.
1995: Filomena Cetani; Sabine Costagliola; Massimo Tonacchera; V Panneels; Gilbert Vassart; Marian Ludgate
The thyroperoxidase doublet is not produced by alternative splicing.
Molecular and cellular endocrinology 1995;115(2):125-32.
1995: Gilbert Vassart; F Desarnaud; Laurence Duprez; D Eggerickx; O Labbé; F Libert; C Mollereau; Jasmine Parma; R Paschke; Massimo Tonacchera
The G protein-coupled receptor family and one of its members, the TSH receptor.
Annals of the New York Academy of Sciences 1995;766():23-30.
1995: Jacqueline Van Sande; Jasmine Parma; Massimo Tonacchera; S Swillens; J Dumont; Gilbert Vassart
Somatic and germline mutations of the TSH receptor gene in thyroid diseases.
The Journal of clinical endocrinology and metabolism 1995;80(9):2577-85.
1995: Jasmine Parma; Jacqueline Van Sande; S Swillens; Massimo Tonacchera; J Dumont; Gilbert Vassart
Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas: identification of additional mutations activating both the cyclic adenosine 3',5'-monophosphate and inositol phosphate-Ca2+ cascades.
Molecular endocrinology (Baltimore, Md.) 1995;9(6):725-33.
1995: Luca Chiovato; Paolo Vitti; G Bendinelli; Ferruccio Santini; Emilio Fiore; Massimo Tonacchera; Claudia Mammoli; A Capaccioli; S Venturi; E Pretell
Humoral thyroid autoimmunity is not involved in the pathogenesis of myxedematous endemic cretinism.
The Journal of clinical endocrinology and metabolism 1995;80(5):1509-14.
1995: Massimo Tonacchera; Filomena Cetani; Sabine Costagliola; L Alcalde; R Uibo; Gilbert Vassart; Marian Ludgate
Mapping thyroid peroxidase epitopes using recombinant protein fragments.
European journal of endocrinology / European Federation of Endocrine Societies 1995;132(1):53-61.
1994: R Paschke; Massimo Tonacchera; Jacqueline Van Sande; Jasmine Parma; Gilbert Vassart
Identification and functional characterization of two new somatic mutations causing constitutive activation of the thyrotropin receptor in hyperfunctioning autonomous adenomas of the thyroid.
The Journal of clinical endocrinology and metabolism 1994;79(6):1785-9.
1994: Sabine Costagliola; Marie-Christine Many; M Stalmans-Falys; Massimo Tonacchera; Gilbert Vassart; Marian Ludgate
Recombinant thyrotropin receptor and the induction of autoimmune thyroid disease in BALB/c mice: a new animal model.
Endocrinology 1994;135(5):2150-9.
1994: Luca Chiovato; Paolo Vitti; G Bendinelli; Ferruccio Santini; Emilio Fiore; A Capaccioli; Massimo Tonacchera; Claudia Mammoli; Marian Ludgate; Aldo Pinchera
Detection of antibodies blocking thyrotropin effect using Chinese hamster ovary cells transfected with the cloned human TSH receptor.
Journal of endocrinological investigation 1994;17(10):809-16.
1994: Luca Persani; Carmela Asteria; Massimo Tonacchera; Paolo Vitti; V Krishna; K Chatterjee; Paolo Beck-Peccoz
Evidence for the secretion of thyrotropin with enhanced bioactivity in syndromes of thyroid hormone resistance.
The Journal of clinical endocrinology and metabolism 1994;78(5):1034-9.
1994: Luca Chiovato; Enio Martino; Massimo Tonacchera; Ferruccio Santini; Paola Lapi; Claudia Mammoli; Lewis E Braverman; Aldo Pinchera
Studies on the in vitro cytotoxic effect of amiodarone.
Endocrinology 1994;134(5):2277-82.
1994: Paolo Vitti; Luca Chiovato; Massimo Tonacchera; G Bendinelli; Claudia Mammoli; A Capaccioli; Emilio Fiore; E Pretell; Aldo Pinchera
Failure to detect thyroid growth-promoting activity in immunoglobulin G of patients with endemic goiter.
The Journal of clinical endocrinology and metabolism 1994;78(5):1020-5.
1994: Jasmine Parma; Laurence Duprez; Jacqueline Van Sande; R Paschke; Massimo Tonacchera; J Dumont; Gilbert Vassart
Constitutively active receptors as a disease-causing mechanism.
Molecular and cellular endocrinology 1994;100(1-2):159-62.
1994: Sabine Costagliola; L Alcalde; Massimo Tonacchera; J Ruf; Gilbert Vassart; Marian Ludgate
Induction of thyrotropin receptor (TSH-R) autoantibodies and thyroiditis in mice immunised with the recombinant TSH-R.
Biochemical and biophysical research communications 1994;199(2):1027-34.
1993: Luca Persani; Massimo Tonacchera; Paolo Beck-Peccoz; Paolo Vitti; Claudia Mammoli; Luca Chiovato; R Elisei; G Faglia; Marian Ludgate; G Vassart
Measurement of cAMP accumulation in Chinese hamster ovary cells transfected with the recombinant human TSH receptor (CHO-R): a new bioassay for human thyrotropin.
Journal of endocrinological investigation 1993;16(7):511-9.
1993: Luca Chiovato; Paola Lapi; Emilio Fiore; Massimo Tonacchera; Aldo Pinchera
Thyroid autoimmunity and female gender.
Journal of endocrinological investigation 1993;16(5):384-91.
1993: Paolo Vitti; R Elisei; Massimo Tonacchera; Luca Chiovato; F Mancusi; Teresa Rago; Claudia Mammoli; Marian Ludgate; G Vassart; Aldo Pinchera
Detection of thyroid-stimulating antibody using Chinese hamster ovary cells transfected with cloned human thyrotropin receptor.
The Journal of clinical endocrinology and metabolism 1993;76(2):499-503.
1992: Stefano Mariotti; Patrizio Caturegli; Giuseppe Barbesino; Michele Marinò; Gianfranco Del Prete; Luca Chiovato; Massimo Tonacchera; M De Carli; Aldo Pinchera
Thyroid function and thyroid autoimmunity independently modulate serum concentration of soluble interleukin 2 (IL-2) receptor (sIL-2R) in thyroid diseases.
Clinical endocrinology 1992;37(5):415-22.
1992: Paolo Vitti; Luca Chiovato; Massimo Tonacchera; G Bendinelli; Claudia Mammoli; A Capaccioli; M Giachetti; Aldo Pinchera
Use of FRTL-5 for the study of thyroid antibodies involved in goitrogenesis.
Thyroidology / A.P.R.I.M 1992;4(1):49-51.
1992: Paolo Vitti; Teresa Rago; F Mancusi; S Pallini; Massimo Tonacchera; Ferruccio Santini; Luca Chiovato; Claudio Marcocci; Aldo Pinchera
Thyroid hypoechogenic pattern at ultrasonography as a tool for predicting recurrence of hyperthyroidism after medical treatment in patients with Graves' disease.
Acta endocrinologica 1992;126(2):128-31.
1992: Luca Chiovato; Massimo Tonacchera; Paola Lapi; Emilio Fiore; Paolo Vitti; Aldo Pinchera
Thyroid autoimmunity and neuropsychological development.
Acta medica Austriaca 1992;19 Suppl 1():91-5.
1992: Paolo Beck-Peccoz; Donatella Cortelazzi; Luca Persani; M J Papandreou; Carmela Asteria; Stefano Borgato; D Preziati; Massimo Tonacchera; Paolo Vitti; A M Baggiani
Maturation of pituitary-thyroid function in the anencephalic fetus.
Acta medica Austriaca 1992;19 Suppl 1():72-6.
1991: Luca Chiovato; Laura Giusti; Massimo Tonacchera; M Ciampi; Claudia Mammoli; F Lippi; Paola Lapi; Stefania Bargagna; P Dini; G Ferretti
Evaluation of L-thyroxine replacement therapy in children with congenital hypothyroidism.
Journal of endocrinological investigation 1991;14(11):957-64.
1990: Luca Chiovato; Paolo Vitti; Ferruccio Santini; G Lopez; Claudia Mammoli; P Bassi; Laura Giusti; Massimo Tonacchera; G Fenzi; Aldo Pinchera
Incidence of antibodies blocking thyrotropin effect in vitro in patients with euthyroid or hypothyroid autoimmune thyroiditis.
The Journal of clinical endocrinology and metabolism 1990;71(1):40-5.