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Peter Tonge

Research Profile

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Mycobacterium tuberculosis

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TOP 3
Kanishk Kapilashrami; Pilho Kim; Cheng-Tsung Lai; Carl A Machutta; Francis Picart; Carlos Simmerling; Gopal R Bommineni; Peter J Tonge
Thiolactomycin-based β-ketoacyl-AcpM synthase A (KasA) inhibitors: fragment-based inhibitor discovery using transient one-dimensional nuclear overhauser effect NMR spectroscopy.
Johannes Schiebel; Peter J Tonge; Michael V Baxter; Andrew Chang; Hao Lu; Caroline Kisker
Staphylococcus aureus FabI: inhibition, substrate recognition, and potential implications for in vivo essentiality.
Maria W Hirschbeck; Jochen Kuper; Nina Liu; Hao Lu; Carla Neckles; Sonam Shah; Christoph A Sotriffer; Peter J Tonge; Steffen Wagner; Caroline Kisker
Structure of the Yersinia pestis FabV enoyl-ACP reductase and its interaction with two 2-pyridone inhibitors.

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All Publications

2013: Kanishk Kapilashrami; Pilho Kim; Cheng-Tsung Lai; Carl A Machutta; Francis Picart; Carlos Simmerling; Gopal R Bommineni; Peter J Tonge
Thiolactomycin-based β-ketoacyl-AcpM synthase A (KasA) inhibitors: fragment-based inhibitor discovery using transient one-dimensional nuclear overhauser effect NMR spectroscopy.
The Journal of biological chemistry 2013;288(9):6045-52.
2012: Johannes Schiebel; Peter J Tonge; Michael V Baxter; Andrew Chang; Hao Lu; Caroline Kisker
Staphylococcus aureus FabI: inhibition, substrate recognition, and potential implications for in vivo essentiality.
Structure (London, England : 1993) 2012;20(5):802-13.
2012: Maria W Hirschbeck; Jochen Kuper; Nina Liu; Hao Lu; Carla Neckles; Sonam Shah; Christoph A Sotriffer; Peter J Tonge; Steffen Wagner; Caroline Kisker
Structure of the Yersinia pestis FabV enoyl-ACP reductase and its interaction with two 2-pyridone inhibitors.
Structure (London, England : 1993) 2012;20(1):89-100.
2012: Pan Pan; Peter J Tonge
Targeting InhA, the FASII enoyl-ACP reductase: SAR studies on novel inhibitor scaffolds.
Current topics in medicinal chemistry 2012;12(7):672-93.
2011: Janine G Borgaro; Andrew Chang; Carl A Machutta; Xujie Zhang; Peter J Tonge
Substrate recognition by β-ketoacyl-ACP synthases.
Biochemistry 2011;50(49):10678-86.
2011: Huei-Jiun Li; Xiaokai Li; Nina Liu; Shambhavi Mishra; Miguel Garcia-Diaz; Caroline Kisker; James J Truglio; Huaning Zhang; Peter J Tonge
Mechanism of the intramolecular Claisen condensation reaction catalyzed by MenB, a crotonase superfamily member.
Biochemistry 2011;50(44):9532-44.
2011: Wook Lee; Sylvia R Luckner; Peter J Tonge; Caroline Kisker; Bernd Engels
Elucidation of the protonation states of the catalytic residues in mtKasA: implications for inhibitor design.
Biochemistry 2011;50(25):5743-56.
2011: Nina Liu; Jason E Cummings; Kathleen England; Richard Slayden; Peter J Tonge
Mechanism and inhibition of the FabI enoyl-ACP reductase from Burkholderia pseudomallei.
The Journal of antimicrobial chemotherapy 2011;66(3):564-73.
2011: Allison Haigney; Andras Lukacs; Rui-Kun Zhao; Allison L Stelling; Richard Brust; Ryu-Ryun Kim; Minako Kondo; Ian Clark; Michael Towrie; Gregory M Greetham; Boris Illarionov; Adelbert Bacher; Werner Römisch-Margl; Markus Fischer; Stephen R Meech; Peter J Tonge
Ultrafast infrared spectroscopy of an isotope-labeled photoactivatable flavoprotein.
Biochemistry 2011;50(8):1321-8.
2011: Kunal Kumar; Seung-Yub Lee; Divya Awasthi; Susan Knudson; Bela Ruzsicska; Richard A Slayden; Peter J Tonge; Ilaria Zanardi; Iwao Ojima
Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents.
Journal of medicinal chemistry 2011;54(1):374-81.
2010: Xiaokai Li; Nina Liu; Huaning Zhang; Susan Knudson; Richard Slayden; Peter J Tonge
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters 2010;20(21):6306-9.
2010: Kunal Kumar; Divya Awasthi; William T Berger; Peter J Tonge; Richard A Slayden; Iwao Ojima
Discovery of anti-TB agents that target the cell-division protein FtsZ.
Future medicinal chemistry 2010;2(8):1305-23.
2010: Hao Lu; Peter J Tonge
Drug-target residence time: critical information for lead optimization.
Current opinion in chemical biology 2010;14(4):467-74.
2010: Sylvia R Luckner; Nina Liu; Christopher W am Ende; Peter J Tonge; Caroline Kisker
A slow, tight binding inhibitor of InhA, the enoyl-acyl carrier protein reductase from Mycobacterium tuberculosis.
The Journal of biological chemistry 2010;285(19):14330-7.
2010: Li Liu; Youwen Xu; Colleen Shea; Joanna S Fowler; Jacob M Hooker; Peter J Tonge
Radiosynthesis and bioimaging of the tuberculosis chemotherapeutics isoniazid, rifampicin and pyrazinamide in baboons.
Journal of medicinal chemistry 2010;53(7):2882-91.
2009: Kathleen England; Christopher am Ende; Hao Lu; Todd J Sullivan; Nicole L Marlenee; Richard A Bowen; Susan Knudson; Dennis L Knudson; Peter J Tonge; Richard Slayden
Substituted diphenyl ethers as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemia.
The Journal of antimicrobial chemotherapy 2009;64(5):1052-61.
2009: Hao Lu; Kathleen England; Christopher am Ende; James J Truglio; Sylvia Luckner; Gopal R Bommineni; Nicole L Marlenee; Susan Knudson; Dennis L Knudson; Richard A Bowen; Caroline Kisker; Richard Slayden; Peter J Tonge
Slow-onset inhibition of the FabI enoyl reductase from francisella tularensis: residence time and in vivo activity.
ACS chemical biology 2009;4(3):221-31.
2008: Nicole A Kruh; Janine G Borgaro; Béla P Ruzsicska; Hua Xu; Peter J Tonge
A novel interaction linking the FAS-II and phthiocerol dimycocerosate (PDIM) biosynthetic pathways.
The Journal of biological chemistry 2008;283(46):31719-25.
2008: Laurel Respicio; Pravin A Nair; Qing Huang; Burcu Anil; Sylvia Tracz; James J Truglio; Caroline Kisker; Daniel P Raleigh; Iwao Ojima; Dennis L Knudson; Peter J Tonge; Richard Slayden
Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery.
Tuberculosis (Edinburgh, Scotland) 2008;88(5):420-9.
2008: Christopher W am Ende; Susan Knudson; Nina Liu; James Childs; Todd J Sullivan; Melissa Boyne; Hua Xu; Yelizaveta Gegina; Dennis L Knudson; Francis Johnson; Charles A Peloquin; Richard Slayden; Peter J Tonge
Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(10):3029-33.
2008: Deborah Stoner-Ma; Andrew A Jaye; Kate L Ronayne; Jérôme Nappa; Stephen R Meech; Peter J Tonge
An alternate proton acceptor for excited-state proton transfer in green fluorescent protein: rewiring GFP.
Journal of the American Chemical Society 2008;130(4):1227-35.
2007: Allison L Stelling; Kate L Ronayne; Jérôme Nappa; Peter J Tonge; Stephen R Meech
Ultrafast structural dynamics in BLUF domains: transient infrared spectroscopy of AppA and its mutants.
Journal of the American Chemical Society 2007;129(50):15556-64.
2007: Melissa E Boyne; Todd J Sullivan; Christopher W amEnde; Hao Lu; Veronica Gruppo; Darragh Heaslip; Anita G Amin; Delphi Chatterjee; Anne J Lenaerts; Peter J Tonge; Richard Slayden
Targeting fatty acid biosynthesis for the development of novel chemotherapeutics against Mycobacterium tuberculosis: evaluation of A-ring-modified diphenyl ethers as high-affinity InhA inhibitors.
Antimicrobial agents and chemotherapy 2007;51(10):3562-7.
2007: Nicole A Kruh; Richa Rawat; Béla P Ruzsicska; Peter J Tonge
Probing mechanisms of resistance to the tuberculosis drug isoniazid: Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis.
Protein science : a publication of the Protein Society 2007;16(8):1617-27.
2007: Alasdair F Bell; Christopher F Stratton; Xujie Zhang; Polina Novichenok; Andrew A Jaye; Pravin A Nair; Sapan Parikh; Richa Rawat; Peter J Tonge
Evidence from Raman spectroscopy that InhA, the mycobacterial enoyl reductase, modulates the conformation of the NADH cofactor to promote catalysis.
Journal of the American Chemical Society 2007;129(20):6425-31.
2007: Jacque Zwahlen; Subramaniapillai Kolappan; Rong Zhou; Caroline Kisker; Peter J Tonge
Structure and mechanism of MbtI, the salicylate synthase from Mycobacterium tuberculosis.
Biochemistry 2007;46(4):954-64.
2007: Subramaniapillai Kolappan; Jacque Zwahlen; Rong Zhou; James J Truglio; Peter J Tonge; Caroline Kisker
Lysine 190 is the catalytic base in MenF, the menaquinone-specific isochorismate synthase from Escherichia coli: implications for an enzyme family.
Biochemistry 2007;46(4):946-53.
2007: Qing Huang; Peter J Tonge; Richard Slayden; Teruo Kirikae; Iwao Ojima
FtsZ: a novel target for tuberculosis drug discovery.
Current topics in medicinal chemistry 2007;7(5):527-43.
2007: Peter J Tonge; Caroline Kisker; Richard Slayden
Development of modern InhA inhibitors to combat drug resistant strains of Mycobacterium tuberculosis.
Current topics in medicinal chemistry 2007;7(5):489-98.
2006: Salma Rafi; Polina Novichenok; Subramaniapillai Kolappan; Xujie Zhang; Christopher F Stratton; Richa Rawat; Caroline Kisker; Carlos Simmerling; Peter J Tonge
Structure of acyl carrier protein bound to FabI, the FASII enoyl reductase from Escherichia coli.
The Journal of biological chemistry 2006;281(51):39285-93.
2006: Deborah Stoner-Ma; Edward H Melief; Jérôme Nappa; Kate L Ronayne; Peter J Tonge; Stephen R Meech
Proton relay reaction in green fluorescent protein (GFP): Polarization-resolved ultrafast vibrational spectroscopy of isotopically edited GFP.
The journal of physical chemistry. B 2006;110(43):22009-18.
2006: Minako Kondo; Jérôme Nappa; Kate L Ronayne; Allison L Stelling; Peter J Tonge; Stephen R Meech
Ultrafast vibrational spectroscopy of the flavin chromophore.
The journal of physical chemistry. B 2006;110(41):20107-10.
2006: Salma B Rafi; Guanglei Cui; Kun Song; Xiaolin Cheng; Peter J Tonge; Carlos Simmerling
Insight through molecular mechanics Poisson-Boltzmann surface area calculations into the binding affinity of triclosan and three analogues for FabI, the E. coli enoyl reductase.
Journal of medicinal chemistry 2006;49(15):4574-80.
2006: Brian P Callahan; Alasdair F Bell; Peter J Tonge; Richard Wolfenden
A Raman-active competitive inhibitor of OMP decarboxylase.
Bioorganic chemistry 2006;34(2):59-65.
2006: Todd J Sullivan; James J Truglio; Melissa E Boyne; Polina Novichenok; Xujie Zhang; Christopher F Stratton; Huei Jiun Li; Tejinder Kaur; Amol Amin; Francis Johnson; Richard Slayden; Caroline Kisker; Peter J Tonge
High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis.
ACS chemical biology 2006;1(1):43-53.
2006: Qing Huang; Fumiko Kirikae; Teruo Kirikae; Antonella Pepe; Amol Amin; Laurel Respicio; Richard Slayden; Peter J Tonge; Iwao Ojima
Targeting FtsZ for antituberculosis drug discovery: noncytotoxic taxanes as novel antituberculosis agents.
Journal of medicinal chemistry 2006;49(2):463-6.
2005: Loretha Carlisle-Moore; Chris R Gordon; Carl A Machutta; W Todd Miller; Peter J Tonge
Substrate recognition by the human fatty-acid synthase.
The Journal of biological chemistry 2005;280(52):42612-8.
2005: Charles Doll; Alasdair F Bell; Nicholas P Power; Peter J Tonge; Peter A Tipton
Procatalytic ligand strain. Ionization and perturbation of 8-nitroxanthine at the urate oxidase active site.
Biochemistry 2005;44(34):11440-6.
2005: Jiaquan Wu; Alasdair F Bell; Andrew A Jaye; Peter J Tonge
Ring current effects in the active site of medium-chain Acyl-CoA dehydrogenase revealed by NMR spectroscopy.
Journal of the American Chemical Society 2005;127(23):8424-32.
2005: Deborah Stoner-Ma; Andrew A Jaye; Pavel Matousek; Michael Towrie; Stephen R Meech; Peter J Tonge
Observation of excited-state proton transfer in green fluorescent protein using ultrafast vibrational spectroscopy.
Journal of the American Chemical Society 2005;127(9):2864-5.
2004: Sharada Sivaraman; Todd J Sullivan; Francis Johnson; Polina Novichenok; Guanglei Cui; Carlos Simmerling; Peter J Tonge
Inhibition of the bacterial enoyl reductase FabI by triclosan: a structure-reactivity analysis of FabI inhibition by triclosan analogues.
Journal of medicinal chemistry 2004;47(3):509-18.
2003: Richa Rawat; Adrian Whitty; Peter J Tonge
The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):13881-6.
2003: James J Truglio; Karsten Theis; Yuguo Feng; Ramona Gajda; Carl Machutta; Peter J Tonge; Caroline Kisker
Crystal structure of Mycobacterium tuberculosis MenB, a key enzyme in vitamin K2 biosynthesis.
The Journal of biological chemistry 2003;278(43):42352-60.
2003: Jiaquan Wu; Alasdair F Bell; Lian Luo; Avery W Stephens; Marian T Stankovich; Peter J Tonge
Probing hydrogen-bonding interactions in the active site of medium-chain acyl-CoA dehydrogenase using Raman spectroscopy.
Biochemistry 2003;42(40):11846-56.
2003: Xiang He; Alasdair F Bell; Peter J Tonge
Ground state isomerization of a model green fluorescent protein chromophore.
FEBS letters 2003;549(1-3):35-8.
2003: Alasdair F Bell; Deborah Stoner-Ma; Rebekka M Wachter; Peter J Tonge
Light-driven decarboxylation of wild-type green fluorescent protein.
Journal of the American Chemical Society 2003;125(23):6919-26.
2003: Sharada Sivaraman; Jacque Zwahlen; Alasdair F Bell; Lizbeth Hedstrom; Peter J Tonge
Structure-activity studies of the inhibition of FabI, the enoyl reductase from Escherichia coli, by triclosan: kinetic analysis of mutant FabIs.
Biochemistry 2003;42(15):4406-13.
2003: S Boyé; H Krogh; Iben B Nielsen; Steen Brøndsted Nielsen; Steen Uttrup Pedersen; Ulrik V Pedersen; Lars H Andersen; Alasdair F Bell; X He; Peter J Tonge
Vibrationally resolved photoabsorption spectroscopy of red fluorescent protein chromophore anions.
Physical review letters 2003;90(11):118103.
2002: Alasdair F Bell; Yuguo Feng; Hilary A Hofstein; Sapan Parikh; Jiaquan Wu; Michael J Rudolph; Caroline Kisker; Adrian Whitty; Peter J Tonge
Stereoselectivity of enoyl-CoA hydratase results from preferential activation of one of two bound substrate conformers.
Chemistry & biology 2002;9(11):1247-55.
2002: Yuguo Feng; Hilary A Hofstein; Jacque Zwahlen; Peter J Tonge
Effect of mutagenesis on the stereochemistry of enoyl-CoA hydratase.
Biochemistry 2002;41(42):12883-90.
2002: Xiang He; Alasdair F Bell; Peter J Tonge
Synthesis and spectroscopic studies of model red fluorescent protein chromophores.
Organic letters 2002;4(9):1523-6.
2001: Alasdair F Bell; Jiaquan Wu; Yuguo Feng; Peter J Tonge
Involvement of glycine 141 in substrate activation by enoyl-CoA hydratase.
Biochemistry 2001;40(6):1725-33.
2001: M Dai; Y Feng; Peter J Tonge
Synthesis of crotonyl-oxyCoA: a mechanistic probe of the reaction catalyzed by enoyl-CoA hydratase.
Journal of the American Chemical Society 2001;123(3):506-7.
2001: Alasdair F Bell; Xiang He; Justin P Ridge; Graeme R Hanson; Alastair G McEwan; Peter J Tonge
Active site heterogeneity in dimethyl sulfoxide reductase from Rhodobacter capsulatus revealed by Raman spectroscopy.
Biochemistry 2001;40(2):440-8.
2000: JD Pellett; KM Sabaj; A W Stephens; Alasdair F Bell; Jiaquan Wu; Peter J Tonge; Marian T Stankovich
Medium-chain acyl-coenzyme A dehydrogenase bound to a product analogue, hexadienoyl-coenzyme A: effects on reduction potential, pK(a), and polarization.
Biochemistry 2000;39(45):13982-92.
2000: S L Parikh; G Xiao; Peter J Tonge
Inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis, by triclosan and isoniazid.
Biochemistry 2000;39(26):7645-50.
2000: Alasdair F Bell; Xiang He; Rebekka M Wachter; Peter J Tonge
Probing the ground state structure of the green fluorescent protein chromophore using Raman spectroscopy.
Biochemistry 2000;39(15):4423-31.
1999: S Parikh; D P Moynihan; G Xiao; Peter J Tonge
Roles of tyrosine 158 and lysine 165 in the catalytic mechanism of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis.
Biochemistry 1999;38(41):13623-34.
1999: Marian T Stankovich; KM Sabaj; Peter J Tonge
Structure/function of medium chain acyl-CoA dehydrogenase: the importance of substrate polarization.
Archives of biochemistry and biophysics 1999;370(1):16-21.
1999: M J Stewart; S Parikh; G Xiao; Peter J Tonge; Caroline Kisker
Structural basis and mechanism of enoyl reductase inhibition by triclosan.
Journal of molecular biology 1999;290(4):859-65.
1999: Hilary A Hofstein; Yuguo Feng; V E Anderson; Peter J Tonge
Role of glutamate 144 and glutamate 164 in the catalytic mechanism of enoyl-CoA hydratase.
Biochemistry 1999;38(29):9508-16.
1997: W J Wu; V E Anderson; Daniel P Raleigh; Peter J Tonge
Structure of hexadienoyl-CoA bound to enoyl-CoA hydratase determined by transferred nuclear Overhauser effect measurements: mechanistic predictions based on the X-ray structure of 4-(chlorobenzoyl)-CoA dehalogenase.
Biochemistry 1997;36(8):2211-20.
1996: J D Doran; Peter J Tonge; J S Mort; Paul R Carey
Deacylation and reacylation for a series of acyl cysteine proteases, including acyl groups derived from novel chromophoric substrates.
Biochemistry 1996;35(38):12487-94.
1995: K L Taylor; R Q Liu; P H Liang; J Price; Debra Dunaway-Mariano; Peter J Tonge; J Clarkson; Paul R Carey
Evidence for electrophilic catalysis in the 4-chlorobenzoyl-CoA dehalogenase reaction: UV, Raman, and 13C-NMR spectral studies of dehalogenase complexes of benzoyl-CoA adducts.
Biochemistry 1995;34(42):13881-8.
1994: R L D'Ordine; B J Bahnson; Peter J Tonge; V E Anderson
Enoyl-coenzyme A hydratase-catalyzed exchange of the alpha-protons of coenzyme A thiol esters: a model for an enolized intermediate in the enzyme-catalyzed elimination?
Biochemistry 1994;33(49):14733-42.
1994: R L D'Ordine; Peter J Tonge; Paul R Carey; V E Anderson
Electronic rearrangement induced by substrate analog binding to the enoyl-CoA hydratase active site: evidence for substrate activation.
Biochemistry 1994;33(42):12635-43.
1992: Peter J Tonge; Paul R Carey
Forces, bond lengths, and reactivity: fundamental insight into the mechanism of enzyme catalysis.
Biochemistry 1992;31(38):9122-5.
1992: Peter J Tonge; B Gour-Salin; P Lachance; AC Storer; Paul R Carey
Resonance Raman spectroscopic and kinetic consequences of a nitrogen ... sulphur enzyme-substrate contact in a series of dithioacylpapains.
Biophysical journal 1992;63(1):191-6.
1991: Peter J Tonge; M Pusztai; A J White; Christopher W Wharton; Paul R Carey
Resonance Raman and Fourier transform infrared spectroscopic studies of the acyl carbonyl group in [3-(5-methyl-2-thienyl)acryloyl]chymotrypsin: evidence for artifacts in the spectra obtained by both techniques.
Biochemistry 1991;30(19):4790-5.
1990: Peter J Tonge; Paul R Carey
Length of the acyl carbonyl bond in acyl-serine proteases correlates with reactivity.
Biochemistry 1990;29(48):10723-7.
1989: Peter J Tonge; Paul R Carey
Direct observation of the titration of substrate carbonyl groups in the active site of alpha-chymotrypsin by resonance Raman spectroscopy.
Biochemistry 1989;28(16):6701-9.
1989: Peter J Tonge; G R Moore; Christopher W Wharton
Fourier-transform infra-red studies of the alkaline isomerization of mitochondrial cytochrome c and the ionization of carboxylic acids.
The Biochemical journal 1989;258(2):599-605.