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Carlo Toniatti

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Jing Yuan; Peter R Strack; Carlo Toniatti; Marc Pelletier
A zinc finger nuclease assay to rapidly quantitate homologous recombination proficiency in human cell lines.
Erica Stec; Berta Strulovici; Stacey Szymanski; Carlo Toniatti; Steven R Bartz; Michael Carleton; Michele A Cleary; Marc Ferrer; Aimee L Jackson; Peter S Linsley; Louis Locco; Rachel H V Needham; Anthony Palmieri; Francesca Santini
A multiplexed siRNA screening strategy to identify genes in the PARP pathway.
Li Wang; Carlo Toniatti; David Valdecanas; K. Kian Ang; Thomas Buchholz; Carolyn Buser-Doepner; Kathy A Mason; Anjili Mathur; Luka Milas
MK-4827, a PARP-1/-2 inhibitor, strongly enhances response of human lung and breast cancer xenografts to radiation.

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All Publications

2013: Jing Yuan; Peter R Strack; Carlo Toniatti; Marc Pelletier
A zinc finger nuclease assay to rapidly quantitate homologous recombination proficiency in human cell lines.
Analytical biochemistry 2013;434(1):96-8.
2012: Erica Stec; Berta Strulovici; Stacey Szymanski; Carlo Toniatti; Steven R Bartz; Michael Carleton; Michele A Cleary; Marc Ferrer; Aimee L Jackson; Peter S Linsley; Louis Locco; Rachel H V Needham; Anthony Palmieri; Francesca Santini
A multiplexed siRNA screening strategy to identify genes in the PARP pathway.
Journal of biomolecular screening 2012;17(10):1316-28.
2012: Li Wang; Carlo Toniatti; David Valdecanas; K. Kian Ang; Thomas Buchholz; Carolyn Buser-Doepner; Kathy A Mason; Anjili Mathur; Luka Milas
MK-4827, a PARP-1/-2 inhibitor, strongly enhances response of human lung and breast cancer xenografts to radiation.
Investigational new drugs 2012;30(6):2113-20.
2012: Paul Warrener; Sybil M G Williams; Matt Biery; Michele A Cleary; Marcia Gordon; Sammy Kim; Peter S Linsley; Carlo Toniatti; Michael Carleton
Synthetic lethality of PARP inhibition in BRCA-network disrupted tumor cells is associated with interferon pathway activation and enhanced by interferon-γ.
Apoptosis : an international journal on programmed cell death 2012;17(7):691-701.
2012: Marieke Aarts; Alan Ashworth; Isaac Garcia-Murillas; Heidrun Gevensleben; Melissa S Hurd; Rachel Sharpe; Stuart D Shumway; Carlo Toniatti; Nicholas C Turner
Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1.
Cancer discovery 2012;2(6):524-39.
2012: Amy D Guertin; Melissa Hurd; Jing Li; Yaping Liu; Melissa M Martin; Nathan R Miselis; Xianlu Qu; Brian Roberts; Yair Benita; Andrew Bloecher; Igor Feldman; Carlo Toniatti; Stuart D Shumway
Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition.
Cancer cell international 2012;12(1):45.
2010: Giovanna Pescatore; Danila Branca; Fabrizio Fiore; Olaf Kinzel; Laura Llauger Bufi; Ester Muraglia; Federica Orvieto; Michael Rowley; Carlo Toniatti; Caterina Torrisi; Philip Jones
Identification and SAR of novel pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).
Bioorganic & medicinal chemistry letters 2010;20(3):1094-9.
2010: Federica Ferrigno; Danila Branca; Olaf Kinzel; Samuele Lillini; Laura Llauger Bufi; Edith Monteagudo; Ester Muraglia; Michael Rowley; Carsten Schultz-Fademrecht; Carlo Toniatti; Caterina Torrisi; Philip Jones
Development of substituted 6-[4-fluoro-3-(piperazin-1-ylcarbonyl)benzyl]-4,5-dimethylpyridazin-3(2H)-ones as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors active in BRCA deficient cells.
Bioorganic & medicinal chemistry letters 2010;20(3):1100-5.
2010: Caterina Torrisi; Monica Bisbocci; Raffaele Ingenito; Jesus M Ontoria; Michael Rowley; Carsten Schultz-Fademrecht; Carlo Toniatti; Philip Jones
Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).
Bioorganic & medicinal chemistry letters 2010;20(2):448-52.
2010: Rita Scarpelli; Julia K Boueres; Mauro Cerretani; Federica Ferrigno; Jesus M Ontoria; Michael Rowley; Carsten Schultz-Fademrecht; Carlo Toniatti; Philip Jones
Synthesis and biological evaluation of substituted 2-phenyl-2H-indazole-7-carboxamides as potent poly(ADP-ribose) polymerase (PARP) inhibitors.
Bioorganic & medicinal chemistry letters 2010;20(2):488-92.
2009: Philip Jones; Sergio Altamura; Julia Boueres; Federica Ferrigno; Massimiliano Fonsi; Claudia Giomini; Stefania Lamartina; Edith Monteagudo; Jesus M Ontoria; Maria Vittoria Orsale; Maria Cecilia Palumbi; Silvia Pesci; Giuseppe Roscilli; Rita Scarpelli; Carsten Schultz-Fademrecht; Carlo Toniatti; Michael Rowley
Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.
Journal of medicinal chemistry 2009;52(22):7170-85.
2009: Danila Branca; Mauro Cerretani; Philip Jones; Uwe Koch; Federica Orvieto; Maria Cecilia Palumbi; Michael Rowley; Carlo Toniatti; Ester Muraglia
Identification of aminoethyl pyrrolo dihydroisoquinolinones as novel poly(ADP-ribose) polymerase-1 inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(15):4042-5.
2009: Federica Orvieto; Danila Branca; Claudia Giomini; Philip Jones; Uwe Koch; Jesus M Ontoria; Maria Cecilia Palumbi; Michael Rowley; Carlo Toniatti; Ester Muraglia
Identification of substituted pyrazolo[1,5-a]quinazolin-5(4H)-one as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(15):4196-200.
2007: Stefania Lamartina; Monica Cimino; Giuseppe Roscilli; Ernesta Dammassa; Lazzaro Domenico; Rossella Rota; Gennaro Ciliberto; Carlo Toniatti
Helper-dependent adenovirus for the gene therapy of proliferative retinopathies: stable gene transfer, regulated gene expression and therapeutic efficacy.
The journal of gene medicine 2007;9(10):862-74.
2006: Olaf Kinzel; Daniela Fattori; Ester Muraglia; paola gallinari; Maria Chiara Nardi; Chantal Paolini; Giuseppe Roscilli; Carlo Toniatti; Odalys Gonzalez Paz; Ralph Laufer; Armin Lahm; Anna Tramontano; Riccardo Cortese; Raffaele De Francesco; Gennaro Ciliberto; Uwe Koch
A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies.
Journal of medicinal chemistry 2006;49(18):5404-7.
2005: paola gallinari; Armin Lahm; Uwe Koch; Chantal Paolini; Maria Chiara Nardi; Giuseppe Roscilli; Olaf Kinzel; Daniela Fattori; Ester Muraglia; Carlo Toniatti; Riccardo Cortese; Raffaele De Francesco; Gennaro Ciliberto
A functionally orthogonal estrogen receptor-based transcription switch specifically induced by a nonsteroid synthetic ligand.
Chemistry & biology 2005;12(8):883-93.
2005: Fumi Kinose; Giuseppe Roscilli; Stefania Lamartina; Kenneth C Anderson; Fabio Bonelli; Stan Spence; Gennaro Ciliberto; Thomas F Vogt; Daniel J Holder; Carlo Toniatti; Catherine J Thut
Inhibition of retinal and choroidal neovascularization by a novel KDR kinase inhibitor.
Molecular vision 2005;11():366-73.
2004: Carlo Toniatti; Hermann Bujard; Riccardo Cortese; Gennaro Ciliberto
Gene therapy progress and prospects: transcription regulatory systems.
Gene therapy 2004;11(8):649-57.
2003: Stefania Lamartina; Luisa Silvi; Giuseppe Roscilli; Danilo R Casimiro; Adam J Simon; Mary-Ellen Davies; John W Shiver; Cira Daniela Rinaudo; Immacolata Zampaglione; Elena Fattori; Stefano Colloca; Odalys Gonzalez Paz; Ralph Laufer; Hermann Bujard; Riccardo Cortese; Gennaro Ciliberto; Carlo Toniatti
Construction of an rtTA2(s)-m2/tts(kid)-based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline in mice and non-human primates.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(2):271-80.
2002: Elena Fattori; Nicola La Monica; Gennaro Ciliberto; Carlo Toniatti
Electro-gene-transfer: a new approach for muscle gene delivery.
Somatic cell and molecular genetics 2002;27(1-6):75-83.
2002: Giuseppe Roscilli; Cira Daniela Rinaudo; Monica Cimino; Elisabetta Sporeno; Stefania Lamartina; Gennaro Ciliberto; Carlo Toniatti
Long-term and tight control of gene expression in mouse skeletal muscle by a new hybrid human transcription factor.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(5):653-63.
2002: Valentina Salucci; Alessia Scarito; Luigi Aurisicchio; Stefania Lamartina; Giancarlo Nicolaus; Saverio Giampaoli; Odalys Gonzalez Paz; Carlo Toniatti; Hermann Bujard; Wolfgang Hillen; Gennaro Ciliberto; Fabio Palombo
Tight control of gene expression by a helper-dependent adenovirus vector carrying the rtTA2(s)-M2 tetracycline transactivator and repressor system.
Gene therapy 2002;9(21):1415-21.
2002: Stefania Lamartina; Giuseppe Roscilli; Cira Daniela Rinaudo; Elisabetta Sporeno; Luisa Silvi; Wolfgang Hillen; Hermann Bujard; Riccardo Cortese; Gennaro Ciliberto; Carlo Toniatti
Stringent control of gene expression in vivo by using novel doxycycline-dependent trans-activators.
Human gene therapy 2002;13(2):199-210.
2001: Selda Samakoglu; Elena Fattori; Stefania Lamartina; Carlo Toniatti; D Stockholm; Jean Michel Heard; Delphine Bohl
betaMinor-globin messenger RNA accumulation in reticulocytes governs improved erythropoiesis in beta thalassemic mice after erythropoietin complementary DNA electrotransfer in muscles.
Blood 2001;97(8):2213-20.
2000: Stefania Lamartina; Gennaro Ciliberto; Carlo Toniatti
Selective cleavage of AAVS1 substrates by the adeno-associated virus type 2 rep68 protein is dependent on topological and sequence constraints.
Journal of virology 2000;74(19):8831-42.
2000: Daniela Rinaudo; Carlo Toniatti
Sensitive ELISA for mouse erythropoietin.
BioTechniques 2000;29(2):218-20.
2000: Stefania Lamartina; Elisabetta Sporeno; Elena Fattori; Carlo Toniatti
Characteristics of the adeno-associated virus preintegration site in human chromosome 19: open chromatin conformation and transcription-competent environment.
Journal of virology 2000;74(16):7671-7.
2000: Daniela Rinaudo; Stefania Lamartina; Giuseppe Roscilli; Gennaro Ciliberto; Carlo Toniatti
Conditional site-specific integration into human chromosome 19 by using a ligand-dependent chimeric adeno-associated virus/Rep protein.
Journal of virology 2000;74(1):281-94.
1999: A Recchia; R J Parks; Stefania Lamartina; Carlo Toniatti; L Pieroni; Fabio Palombo; Gennaro Ciliberto; F L Graham; Riccardo Cortese; Nicola La Monica; Stefano Colloca
Site-specific integration mediated by a hybrid adenovirus/adeno-associated virus vector.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2615-20.
1999: Daniela Frasca; Gino Doria; Paola Barattini; F Guidi; A L Salvati; Carlo Toniatti; Gennaro Ciliberto
Activation of gp130 signaling in vivo by the IL-6 super-agonist K-7/D-6 accelerates repopulation of lymphoid organs after irradiation.
European journal of immunology 1999;29(1):300-10.
1999: N Borsellino; B Bonavida; Gennaro Ciliberto; Carlo Toniatti; Salvatore Travali; Natale D'Alessandro
Blocking signaling through the Gp130 receptor chain by interleukin-6 and oncostatin M inhibits PC-3 cell growth and sensitizes the tumor cells to etoposide and cisplatin-mediated cytotoxicity.
Cancer 1999;85(1):134-44.
1998: Stefania Lamartina; Giuseppe Roscilli; Daniela Rinaudo; P Delmastro; Carlo Toniatti
Lipofection of purified adeno-associated virus Rep68 protein: toward a chromosome-targeting nonviral particle.
Journal of virology 1998;72(9):7653-8.
1997: E Di Santo; Tonino Alonzi; Valeria Poli; Elena Fattori; Carlo Toniatti; Marina Sironi; P Ricciardi-Castagnoli; Pietro Ghezzi
Differential effects of IL-6 on systemic and central production of TNF: a study with IL-6-deficient mice.
Cytokine 1997;9(5):300-6.
1997: M Romano; Marina Sironi; Carlo Toniatti; Nadia Polentarutti; P Fruscella; Pietro Ghezzi; R Faggioni; Walter Luini; V van Hinsbergh; Silvano Sozzani; Federico Bussolino; Valeria Poli; Gennaro Ciliberto; Alberto Mantovani
Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment.
Immunity 1997;6(3):315-25.
1996: Carlo Toniatti; A Cabibbo; E Sporena; A L Salvati; M Cerretani; S Serafini; Armin Lahm; Riccardo Cortese; Gennaro Ciliberto
Engineering human interleukin-6 to obtain variants with strongly enhanced bioactivity.
The EMBO journal 1996;15(11):2726-37.
1996: E Sporeno; Rocco Savino; Laura Ciapponi; Giacomo Paonessa; A Cabibbo; Armin Lahm; K Pulkki; R X Sun; Carlo Toniatti; B Klein; Gennaro Ciliberto
Human interleukin-6 receptor super-antagonists with high potency and wide spectrum on multiple myeloma cells.
Blood 1996;87(11):4510-9.
1996: Luigina Romani; Antonella Mencacci; Elio Cenci; Roberta Spaccapelo; Carlo Toniatti; Paolo Puccetti; Francesco Bistoni; Valeria Poli
Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans.
The Journal of experimental medicine 1996;183(4):1345-55.
1996: F Martin; Carlo Toniatti; A L Salvati; Gennaro Ciliberto; Riccardo Cortese; maurizio sollazzo
Coupling protein design and in vitro selection strategies: improving specificity and affinity of a designed beta-protein IL-6 antagonist.
Journal of molecular biology 1996;255(1):86-97.
1996: Z Chai; S Gatti; Carlo Toniatti; Valeria Poli; Tamas Bartfai
Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1 beta: a study on IL-6-deficient mice.
The Journal of experimental medicine 1996;183(1):311-6.
1995: A Cabibbo; E Sporeno; Carlo Toniatti; Sergio Altamura; Rocco Savino; Giacomo Paonessa; Gennaro Ciliberto
Monovalent phage display of human interleukin (hIL)-6: selection of superbinder variants from a complex molecular repertoire in the hIL-6 D-helix.
Gene 1995;167(1-2):41-7.
1995: Armin Lahm; Rocco Savino; A L Salvati; A Cabibbo; Laura Ciapponi; A Demartis; Carlo Toniatti; Giacomo Paonessa; Sergio Altamura; Gennaro Ciliberto
The molecular design of human IL-6 receptor antagonists.
Annals of the New York Academy of Sciences 1995;762():136-50; discussion 150-1.
1995: A L Salvati; Armin Lahm; Giacomo Paonessa; Gennaro Ciliberto; Carlo Toniatti
Interleukin-6 (IL-6) antagonism by soluble IL-6 receptor alpha mutated in the predicted gp130-binding interface.
The Journal of biological chemistry 1995;270(20):12242-9.
1995: A Silvani; G Ferrari; Giacomo Paonessa; Carlo Toniatti; Giorgio Parmiani; Mario P Colombo
Down-regulation of interleukin 6 receptor alpha chain in interleukin 6 transduced melanoma cells causes selective resistance to interleukin 6 but not to oncostatin M.
Cancer research 1995;55(10):2200-5.
1995: Giacomo Paonessa; Rita Graziani; A De Serio; Rocco Savino; Laura Ciapponi; Armin Lahm; A L Salvati; Carlo Toniatti; Gennaro Ciliberto
Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.
The EMBO journal 1995;14(9):1942-51.
1994: Rocco Savino; Laura Ciapponi; Armin Lahm; A Demartis; A Cabibbo; Carlo Toniatti; P Delmastro; Sergio Altamura; Gennaro Ciliberto
Rational design of a receptor super-antagonist of human interleukin-6.
The EMBO journal 1994;13(24):5863-70.
1994: F Martin; Carlo Toniatti; A L Salvati; S Venturini; Gennaro Ciliberto; Riccardo Cortese; maurizio sollazzo
The affinity-selection of a minibody polypeptide inhibitor of human interleukin-6.
The EMBO journal 1994;13(22):5303-9.
1994: E Sporeno; Giacomo Paonessa; A L Salvati; Rita Graziani; P Delmastro; Gennaro Ciliberto; Carlo Toniatti
Oncostatin M binds directly to gp130 and behaves as interleukin-6 antagonist on a cell line expressing gp130 but lacking functional oncostatin M receptors.
The Journal of biological chemistry 1994;269(15):10991-5.
1994: Rocco Savino; Armin Lahm; A L Salvati; Laura Ciapponi; E Sporeno; Sergio Altamura; Giacomo Paonessa; Carlo Toniatti; Gennaro Ciliberto
Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation.
The EMBO journal 1994;13(6):1357-67.
1994: A Wallace; Sergio Altamura; Carlo Toniatti; alessandra vitelli; Elisabetta Bianchi; P Delmastro; Gennaro Ciliberto; Antonello Pessi
A Multimeric Synthetic Peptide Combinatorial Library.
Peptide research 1994;7(1):27-31.
1993: Carlo Toniatti; Paolo MONACI; Alfredo Nicosia; Riccardo Cortese; Gennaro Ciliberto
A bipartite activation domain is responsible for the activity of transcription factor HNF1/LFB1 in cells of hepatic and nonhepatic origin.
DNA and cell biology 1993;12(3):199-208.
1990: Carlo Toniatti; A Demartis; Paolo MONACI; Alfredo Nicosia; Gennaro Ciliberto
Synergistic trans-activation of the human C-reactive protein promoter by transcription factor HNF-1 binding at two distinct sites.
The EMBO journal 1990;9(13):4467-75.