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Thomas Aigner

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J Rose; Norbert Schmitz; S Sesselmann; C Skhirtladze; Stephan Söder; Pia Gebhard; Thomas Aigner
DNA damage, discoordinated gene expression and cellular senescence in osteoarthritic chondrocytes.
Bastian Marquass; Georg Osterhoff; Robert Richter; Stefanie Schmidt; Ronny Schulz; Frank Stein; Matthias Zscharnack; Thomas Aigner; Gabriele Aust; Pierre Hepp; Christoph Josten; Augustinus Bader
Matrix-associated implantation of predifferentiated mesenchymal stem cells versus articular chondrocytes: in vivo results of cartilage repair after 1 year.
Susan Chubinskaya; Thomas Aigner; Jeffrey A Borgia; Lori Otten; David C Rueger; Stephan Soeder; Richard F Loeser
Regulation of chondrocyte gene expression by osteogenic protein-1.

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All Publications

2012: J Rose; Norbert Schmitz; S Sesselmann; C Skhirtladze; Stephan Söder; Pia Gebhard; Thomas Aigner
DNA damage, discoordinated gene expression and cellular senescence in osteoarthritic chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2012;20(9):1020-8.
2011: Bastian Marquass; Georg Osterhoff; Robert Richter; Stefanie Schmidt; Ronny Schulz; Frank Stein; Matthias Zscharnack; Thomas Aigner; Gabriele Aust; Pierre Hepp; Christoph Josten; Augustinus Bader
Matrix-associated implantation of predifferentiated mesenchymal stem cells versus articular chondrocytes: in vivo results of cartilage repair after 1 year.
The American journal of sports medicine 2011;39(7):1401-12.
2011: Susan Chubinskaya; Thomas Aigner; Jeffrey A Borgia; Lori Otten; David C Rueger; Stephan Soeder; Richard F Loeser
Regulation of chondrocyte gene expression by osteogenic protein-1.
Arthritis research & therapy 2011;13(2):R55.
2010: Bastian Marquass; J S Somerson; Pierre Hepp; Thomas Aigner; S Schwan; Augustinus Bader; Christoph Josten; Matthias Zscharnack; Rita Schulz
A novel MSC-seeded triphasic construct for the repair of osteochondral defects.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2010;28(12):1586-99.
2010: T Prietzel; Anna Macher; Irina Haferkorn; Nicole Schmitz; Frank Schmidt; Thomas Aigner
Soft tissue metastasis of thyroid carcinoma in the knee region mimicking a paraarticular inflammatory lesion.
Archives of orthopaedic and trauma surgery 2010;130(12):1425-8.
2010: D Adler; Thomas Aigner; Georg von Salis-Soglio; M Gutberlet; C-E Heyde
[Nora's lesion. Discussion of a rare bone proliferation].
Der Orthopäde 2010;39(11):1065-70.
2010: Norbert Schmitz; S Laverty; V B Kraus; Thomas Aigner
Basic methods in histopathology of joint tissues.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2010;18 Suppl 3():S113-6.
2010: Robin Wachowiak; Holger Till; Roman Metzger; Uta Bierbach; Thorsten Simon; Bernhard Sattler; Thomas Aigner; Osama Sabri; Regine Kluge
Residual lymph node metastasis in stage 4 neuroblastoma--advantage of radio-guided surgery?
Pediatric hematology and oncology 2010;27(6):471-5.
2010: Matthias Zscharnack; Pierre Hepp; Robert Richter; Thomas Aigner; Ronny Schulz; Jeremy Somerson; Christoph Josten; Augustinus Bader; Bastian Marquass
Repair of chronic osteochondral defects using predifferentiated mesenchymal stem cells in an ovine model.
The American journal of sports medicine 2010;38(9):1857-69.
2010: J Singer; F Werner; Christian A Koch; Michael Bartels; Thomas Aigner; Thomas Lincke; Mathias Fasshauer; Ralf Paschke
Ectopic Cushing's syndrome caused by a well differentiated ACTH-secreting neuroendocrine carcinoma of the ileum.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2010;118(8):524-9.
2010: Kerstin Dornauer; Stephan Söder; Carrie Y Inwards; Judith Bovee; Thomas Aigner
Matrix biochemistry and cell biology of dedifferentiated chondrosarcomas.
Pathology international 2010;60(5):365-72.
2010: Beate Böhm; Sandra Hess; Kristin Krause; Andrea Schirner; Werner Ewald; Thomas Aigner; Harald Burkhardt
ADAM15 exerts an antiapoptotic effect on osteoarthritic chondrocytes via up-regulation of the X-linked inhibitor of apoptosis.
Arthritis and rheumatism 2010;62(5):1372-82.
2010: N Schmitz; V B Kraus; Thomas Aigner
Targets to tackle--the pathophysiology of the disease.
Current drug targets 2010;11(5):521-7.
2010: Alexander Krenauer; Alexander Moll; Wolfram Pönisch; Nicole Schmitz; Gerald Niedobitek; Dietger Niederwieser; Thomas Aigner
EBV-associated post-transplantation B-cell lymphoproliferative disorder following allogenic stem cell transplantation for acute lymphoblastic leukaemia: tumor regression after reduction of immunosuppression--a case report.
Diagnostic pathology 2010;5():21.
2009: Pierre Hepp; G Osterhoff; M Niederhagen; Bastian Marquass; Thomas Aigner; Augustinus Bader; Christoph Josten; R Schulz
Perilesional changes of focal osteochondral defects in an ovine model and their relevance to human osteochondral injuries.
The Journal of bone and joint surgery. British volume 2009;91(8):1110-9.
2009: Sigrun Ressler; Jasim Radhi; Thomas Aigner; Christine Loo; Werner Zwerschke; Consolato Sergi
Insulin-like growth factor-binding protein-3 in osteosarcomas and normal bone tissues.
Anticancer research 2009;29(7):2579-87.
2009: Jozef Zustin; Thomas Aigner
[Osteoarthritis--histopathologic diagnosis: typing, grading, and staging].
Der Orthopäde 2009;38(6):491-500.
2009: J Haag; R Voigt; S Soeder; Thomas Aigner
Efficient non-viral transfection of primary human adult chondrocytes in a high-throughput format.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2009;17(6):813-7.
2009: T Prietzel; P Hitzler; M Wojan; Thomas Aigner; Georg von Salis-Soglio
[Painful enlargement of the 2nd toe due to an osteoid osteoma in the distal phalanx].
Zeitschrift für Orthopädie und Unfallchirurgie 2009;147(3):362-5.
2009: S Sesselmann; S Söder; R Voigt; J Haag; S P Grogan; Thomas Aigner
DNA methylation is not responsible for p21WAF1/CIP1 down-regulation in osteoarthritic chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2009;17(4):507-12.
2009: T Prietzel; I Haferkorn; A Macher; E Schumann; Georg von Salis-Soglio; Thomas Aigner
[Metastatic malignant choroidal melanoma: a case report about 18 years with palliative operative treatment].
Der Orthopäde 2009;38(3):278-82.
2009: Stefan Karger; Carl Weidinger; Kerstin Krause; Sien-Yi Sheu; Thomas Aigner; Oliver Gimm; Kurt-Werner Schmid; Henning Dralle; Dagmar Führer
FOXO3a: a novel player in thyroid carcinogenesis?
Endocrine-related cancer 2009;16(1):189-99.
2009: Alexander Moll; Alexander Krenauer; Uta Bierbach; Holger Till; Wolfgang Hirsch; Ivo Leuschner; Nicole Schmitz; Christian Wittekind; Thomas Aigner
Mixed hepatoblastoma and teratoma of the liver in a 3-year-old child: a unique combination and clinical challenge.
Diagnostic pathology 2009;4():37.
2008: S Mueller; D Neureiter; Thomas Aigner; M Stolte
Comparison of histological parameters for the diagnosis of eosinophilic oesophagitis versus gastro-oesophageal reflux disease on oesophageal biopsy material.
Histopathology 2008;53(6):676-84.
2008: Ina Knerr; Stephan Söder; Elke Licha; Thomas Aigner; Wolfgang Rascher
Response of HEK293 and CHO cells overexpressing fusiogenic syncytin-1 to mitochondrion-mediated apoptosis induced by antimycin A.
Journal of cellular biochemistry 2008;105(3):766-75.
2008: Kerstin Krause; Stefan Karger; Sien-Yi Sheu; Thomas Aigner; Romy Kursawe; Oliver Gimm; Kurt W Schmid; Henning Dralle; Dagmar Führer
Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis.
The Journal of endocrinology 2008;198(2):291-9.
2008: Katrin Fundel; Jochen Haag; Pia Gebhard; Ralf Zimmer; Thomas Aigner
Normalization strategies for mRNA expression data in cartilage research.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(8):947-55.
2008: Kosei Ijiri; Luiz F Zerbini; Haibing Peng; Hasan H Otu; Kaneyuki Tsuchimochi; Miguel Otero; Cecilia Dragomir; Nicole Walsh; Benjamin E Bierbaum; David Mattingly; Geoff van Flandern; Setsuro Komiya; Thomas Aigner; Towia Libermann; Mary B Goldring
Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes.
Arthritis and rheumatism 2008;58(7):2075-87.
2008: Carol Muehleman; Jun Li; Thomas Aigner; Lev Rappoport; Eric Mattson; Carol Hirschmugl; Koichi Masuda; Ann Rosenthal
Association between crystals and cartilage degeneration in the ankle.
The Journal of rheumatology 2008;35(6):1108-17.
2008: A Behnecke; Thomas Aigner; W Rösler; B Schick
[Septal perforation and palatal defect].
HNO 2008;56(6):623-6.
2008: Thomas Aigner; Stephan Söder
[Typing, grading and staging of osteoarthritis: histopathological assessment of joint degeneration].
Zeitschrift für Rheumatologie 2008;67(1):32-6, 38-40.
2008: Stephan Duerr; Olaf Wendler; Thomas Aigner; Stefanie Karosi; Bernhard Schick
Metalloproteinases in juvenile angiofibroma--a collagen rich tumor.
Human pathology 2008;39(2):259-68.
2008: Pierre Hepp; Thomas Engel; Bastian Marquass; Thomas Aigner; Christoph Josten; Manuel Niederhagen
Infiltration of the pes anserinus complex by an extraarticular diffuse-type giant cell tumor (D-TGCT).
Archives of orthopaedic and trauma surgery 2008;128(2):155-8.
2008: Katrin Fundel; Robert Küffner; Thomas Aigner; Ralf Zimmer
Normalization and gene p-value estimation: issues in microarray data processing.
Bioinformatics and biology insights 2008;2():291-305.
2008: Jochen Haag; Pia Gebhard; Thomas Aigner
SOX gene expression in human osteoarthritic cartilage.
Pathobiology : journal of immunopathology, molecular and cellular biology 2008;75(3):195-9.
2008: Thomas Aigner; Daniel Neureiter; Valentina Câmpean; Stephan Soder; Kerstin Amann
Expression of cartilage-specific markers in calcified and non-calcified atherosclerotic lesions.
Atherosclerosis 2008;196(1):37-41.
2007: Claudia Grimmer; David Pfander; Bernd Swoboda; Thomas Aigner; L Mueller; Friedrich F Hennig; Kolja Gelse
Hypoxia-inducible factor 1alpha is involved in the prostaglandin metabolism of osteoarthritic cartilage through up-regulation of microsomal prostaglandin E synthase 1 in articular chondrocytes.
Arthritis and rheumatism 2007;56(12):4084-94.
2007: C Thomas G Appleton; Shirine E Usmani; Suzanne M Bernier; Thomas Aigner; Frank Beier
Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis.
Arthritis and rheumatism 2007;56(11):3693-705.
2007: N Melling; E Bruder; Arno Dimmler; Werner Hohenberger; Thomas Aigner
Localised massive tumourous xanthomatosis of the small intestine.
International journal of colorectal disease 2007;22(11):1401-4.
2007: Jochen Haag; Thomas Aigner
Identification of calponin 3 as a novel Smad-binding modulator of BMP signaling expressed in cartilage.
Experimental cell research 2007;313(16):3386-94.
2007: Christian Möbius; C Demuth; Thomas Aigner; Marcus Wiedmann; Christian Wittekind; Joachim Mössner; Johann Hauss; Helmut Witzigmann
Evaluation of VEGF A expression and microvascular density as prognostic factors in extrahepatic cholangiocarcinoma.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2007;33(8):1025-9.
2007: Thomas Aigner; Jochen Haag; Ralf Zimmer
Functional genomics, evo-devo and systems biology: a chance to overcome complexity?
Current opinion in rheumatology 2007;19(5):463-70.
2007: Thomas Aigner
Osteoarthritis.
Current opinion in rheumatology 2007;19(5):427-8.
2007: Zhiyong FAN; Stephan Söder; Stephan Oehler; Katrin Fundel; Thomas Aigner
Activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilage.
The American journal of pathology 2007;171(3):938-46.
2007: Susanna Mueller; Thomas Aigner; Jochen Haag; Rene Schwarz; Gerald Niedobitek
Senile EBV-associated B-cell lymphoproliferative disorder of prepatellar bursa in an elderly patient with multifocal urate arthropathy.
Hematological oncology 2007;25(3):140-2.
2007: Elke Ueberham; Thomas Aigner; Uwe Ueberham; Rolf Gebhardt
E-cadherin as a reliable cell surface marker for the identification of liver specific stem cells.
Journal of molecular histology 2007;38(4):359-68.
2007: Thomas Aigner; Tilman Rau; Manuel Niederhagen; Frank Zaucke; Markus Schmitz; Uwe Pöhls; Helmut Stöss; Anita Rauch; Christian T Thiel
Achondrogenesis Type IA (Houston-Harris): a still-unresolved molecular phenotype.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 2007;10(4):328-34.
2007: Thomas Aigner; Stephan Söder; Pia Gebhard; Audrey McAlinden; Jochen Haag
Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis--structure, chaos and senescence.
Nature clinical practice. Rheumatology 2007;3(7):391-9.
2007: Alexander Zien; Pia Gebhard; Katrin Fundel; Thomas Aigner
Phenotyping of chondrocytes in vivo and in vitro using cDNA array technology.
Clinical orthopaedics and related research 2007;460():226-33.
2007: Susan Chubinskaya; A Hakimiyan; Carol Pacione; Adam Yanke; L Rappoport; Thomas Aigner; David C Rueger; Richard F Loeser
Synergistic effect of IGF-1 and OP-1 on matrix formation by normal and OA chondrocytes cultured in alginate beads.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2007;15(4):421-30.
2007: Elke Wühl; Jillene Kogan; Aleksandra Zurowska; Verena Matejas; Rene G Vandevoorde; Thomas Aigner; Olaf Wendler; Iga Lesniewska; Raymonde Bouvier; André Reis; Joachim Weis; Pierre Cochat; Martin Zenker
Neurodevelopmental deficits in Pierson (microcoria-congenital nephrosis) syndrome.
American journal of medical genetics. Part A 2007;143(4):311-9.
2007: Thomas Aigner; N Gerwin
Growth plate cartilage as developmental model in osteoarthritis research--potentials and limitations.
Current drug targets 2007;8(2):377-85.
2007: Thomas Aigner; J Haag; J Martin; J Buckwalter
Osteoarthritis: aging of matrix and cells--going for a remedy.
Current drug targets 2007;8(2):325-31.
2007: Helmtrud I Roach; Thomas Aigner; S Soder; J Haag; H Welkerling
Pathobiology of osteoarthritis: pathomechanisms and potential therapeutic targets.
Current drug targets 2007;8(2):271-82.
2007: Shawn Patrick Grogan; Andrea Barbero; Jose Diaz-Romero; Anne-Marie Cleton-Jansen; Stephan Soeder; Robert Whiteside; Pancras Hogendoorn; jian farhadi; Thomas Aigner; Ivan Martin; PIerre Mainil-Varlet
Identification of markers to characterize and sort human articular chondrocytes with enhanced in vitro chondrogenic capacity.
Arthritis and rheumatism 2007;56(2):586-95.
2007: Helmtrud I Roach; Thomas Aigner
DNA methylation in osteoarthritic chondrocytes: a new molecular target.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2007;15(2):128-37.
2007: Thomas Aigner
[Histogenesis of the skeleton and morphogenesis of cartilage-forming neoplasias].
Verhandlungen der Deutschen Gesellschaft für Pathologie 2007;91():49-56.
2007: Johannes Stöve; L Lehmann; Stefan Fickert; Thomas Aigner; R Brenner
Artificial organs: a new option for treating osteoarthritis.
Current drug delivery 2007;4(1):77-88.
2007: Michael Lell; C Tudor; Thomas Aigner; Peter Kessler
Primary intraosseous meningioma of the mandible: CT and MR imaging features.
AJNR. American journal of neuroradiology 2007;28(1):129-31.
2007: Christian S Haas; Valentina Câmpean; Alexander Kuhlmann; Arno Dimmler; Udo Reulbach; Christian Forster; Thomas Aigner; Till Acker; Karl H Plate; Kerstin Amann
Analysis of glomerular VEGF mRNA and protein expression in murine mesangioproliferative glomerulonephritis.
Virchows Archiv : an international journal of pathology 2007;450(1):81-92.
2006: Jochen Haag; Thomas Aigner
Jun activation domain-binding protein 1 binds Smad5 and inhibits bone morphogenetic protein signaling.
Arthritis and rheumatism 2006;54(12):3878-84.
2006: Thomas Aigner; Katrin Fundel; Joachim Saas; Pia Gebhard; Jochen Haag; Tilo Weiss; Alexander Zien; Franz Obermayr; Ralf Zimmer; Eckart Bartnik
Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis.
Arthritis and rheumatism 2006;54(11):3533-44.
2006: PIerre Mainil-Varlet; R Fischer; H Jülke; Thomas Aigner
[Spontaneous and post-therapeutic cartilage repair: evaluation criteria].
Der Pathologe 2006;27(6):461-8.
2006: Axel J Hueber; Stefan Kallert; Thomas Aigner; Wolf Rösler; Joachim R Kalden; Hendrik Schulze-Koops; Jürgen Rech
Early detection of Richter's transformation: stable disease with dose-reduced gemcitabine and local radiation.
Onkologie 2006;29(11):526-8.
2006: Thomas Aigner; S Söder
[Histopathological examination of joint degeneration: typing, grading and staging of osteoarthritis].
Der Pathologe 2006;27(6):431-8.
2006: Joachim Saas; Jochen Haag; David C Rueger; Susan Chubinskaya; Florian Sohler; Ralf Zimmer; Eckart Bartnik; Thomas Aigner
IL-1beta, but not BMP-7 leads to a dramatic change in the gene expression pattern of human adult articular chondrocytes--portraying the gene expression pattern in two donors.
Cytokine 2006;36(1-2):90-9.
2006: Heike Welkerling; Walter Geissdörfer; Thomas Aigner; Raimund Forst
Osteomyelitis of the ulna caused by Porphyromonas gingivalis.
Journal of clinical microbiology 2006;44(10):3835-7.
2006: Karoliina Pelttari; Anja Winter; Eric Steck; Katrin Goetzke; Thea Hennig; Bjoern Gunnar Ochs; Thomas Aigner; Wiltrud Richter
Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice.
Arthritis and rheumatism 2006;54(10):3254-66.
2006: Tilman Rau; Stephan Soeder; Alexander Olk; Thomas Aigner
Parosteal lipoma of the thigh with cartilaginous and osseous differentiation: an osteochondrolipoma.
Annals of diagnostic pathology 2006;10(5):279-82.
2006: Vahudin Zugor; M Frank; F Steffen Krause; Günter E Schott; Thomas Aigner; Dirk G Engehausen
[B-cell lymphoma of the testes].
Der Urologe. Ausg. A 2006;45(10):1308-11.
2006: J Rose; Stephan Söder; Stephan Oehler; Thomas Aigner
CDRAP is expressed in adult articular cartilage, but its expression is not significantly regulated in osteoarthritic chondrocytes.
Clinical and experimental rheumatology 2006;24(5):573-5.
2006: Thomas Aigner
Cartilage in osteoarthritic joints is not automatically osteoarthritic cartilage.
Development (Cambridge, England) 2006;133(18):3497-8.
2006: Claudia Grimmer; Nadine Balbus; Ute Lang; Thomas Aigner; Thorsten Cramer; Lutz Müller; Bernd Swoboda; David Pfander
Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels.
The American journal of pathology 2006;169(2):491-502.
2006: P Wetzel; Jochen Haag; Valentina Câmpean; roel goldschmeding; A Atalla; Kerstin Amann; Thomas Aigner
Bone morphogenetic protein-7 expression and activity in the human adult normal kidney is predominantly localized to the distal nephron.
Kidney international 2006;70(4):717-23.
2006: Zhiyong FAN; Huiqing Yang; Brigitte Bau; Stephan Söder; Thomas Aigner
Role of mitogen-activated protein kinases and NFkappaB on IL-1beta-induced effects on collagen type II, MMP-1 and 13 mRNA expression in normal articular human chondrocytes.
Rheumatology international 2006;26(10):900-3.
2006: David Pfander; Claudia Grimmer; Thomas Aigner; Bernd Swoboda; R Schmidt; Thorsten Cramer
Pigment epithelium derived factor--the product of the EPC-1 gene--is expressed by articular chondrocytes and up regulated in osteoarthritis.
Annals of the rheumatic diseases 2006;65(7):965-7.
2006: Judith Bovee; Liesbeth Hameetman; Herman M Kroon; Thomas Aigner; Pancras Hogendoorn
EXT-related pathways are not involved in the pathogenesis of dysplasia epiphysealis hemimelica and metachondromatosis.
The Journal of pathology 2006;209(3):411-9.
2006: Lars Morawietz; RA Classen; Jörg Hartmut Schröder; Christian Dynybil; Carsten Perka; Adrian Skwara; Jasper Neidel; Thorsten Gehrke; Lars Frommelt; T Hansen; M Otto; B Barden; Thomas Aigner; Peter Stiehl; T Schubert; Carola Meyer-Scholten; A König; P Ströbel; Christof P Rader; S Kirschner; F Lintner; Wolfgang Rüther; I Bos; Christian Hendrich; Jörg Kriegsmann; Veit Krenn
Proposal for a histopathological consensus classification of the periprosthetic interface membrane.
Journal of clinical pathology 2006;59(6):591-7.
2006: Thomas Aigner; A Sachse; Pia Gebhard; Helmtrud I Roach
Osteoarthritis: pathobiology-targets and ways for therapeutic intervention.
Advanced drug delivery reviews 2006;58(2):128-49.
2006: Thomas Aigner; Nicole Gerwin
Drug delivery in degenerative joint disease.
Advanced drug delivery reviews 2006;58(2):123-4.
2006: Stephan Söder; Helmtrud I Roach; Stephan Oehler; Brigitte Bau; Jochen Haag; Thomas Aigner
MMP-9/gelatinase B is a gene product of human adult articular chondrocytes and increased in osteoarthritic cartilage.
Clinical and experimental rheumatology 2006;24(3):302-4.
2006: Lydia Wachsmuth; Stephan Söder; Zhiyong FAN; Florian Finger; Thomas Aigner
Immunolocalization of matrix proteins in different human cartilage subtypes.
Histology and histopathology 2006;21(5):477-85.
2006: Jochen Haag; Susan Chubinskaya; Thomas Aigner
Hgs physically interacts with Smad5 and attenuates BMP signaling.
Experimental cell research 2006;312(7):1153-63.
2006: Thomas M.K. Völkl; Thorsten Langer; Thomas Aigner; Holger Greess; Jörn D Beck; Anita M Rauch; Helmuth G Dörr
Klinefelter syndrome and mediastinal germ cell tumors.
American journal of medical genetics. Part A 2006;140(5):471-81.
2006: Stephan Söder; Andre M Oliveira; Carrie Y Inwards; S Müller; Thomas Aigner
Type II collagen, but not aggrecan expression, distinguishes clear cell chondrosarcoma and chondroblastoma.
Pathology 2006;38(1):35-8.
2006: Andreas R Klatt; Gabriele Klinger; Olga Neumüller; Bernd Eidenmüller; Ingrid Wagner; Tatjana Achenbach; Thomas Aigner; Eckart Bartnik
TAK1 downregulation reduces IL-1beta induced expression of MMP13, MMP1 and TNF-alpha.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2006;60(2):55-61.
2006: Thomas Aigner; S Soeder; J Haag
IL-1beta and BMPs--interactive players of cartilage matrix degradation and regeneration.
European cells & materials 2006;12():49-56; discussion 56.
2006: Jung Park; Kolja Gelse; Susi Frank; Klaus von der Mark; Thomas Aigner; Holm Schneider
Transgene-activated mesenchymal cells for articular cartilage repair: a comparison of primary bone marrow-, perichondrium/periosteum- and fat-derived cells.
The journal of gene medicine 2006;8(1):112-25.
2005: Cornelius Schörle; Florian Finger; Alexander Zien; J A Block; Pia Gebhard; Thomas Aigner
Phenotypic characterization of chondrosarcoma-derived cell lines.
Cancer letters 2005;226(2):143-54.
2005: Thomas Aigner; Louise A McKenna; Alexander Zien; Zhiyong FAN; Pia Gebhard; Ralf Zimmer
Gene expression profiling of serum- and interleukin-1 beta-stimulated primary human adult articular chondrocytes--a molecular analysis based on chondrocytes isolated from one donor.
Cytokine 2005;31(3):227-40.
2005: Matthias Gebauer; Joachim Saas; Florian Sohler; Jochen Haag; Stephan Söder; M Pieper; Eckart Bartnik; J Beninga; Ralf Zimmer; Thomas Aigner
Comparison of the chondrosarcoma cell line SW1353 with primary human adult articular chondrocytes with regard to their gene expression profile and reactivity to IL-1beta.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2005;13(8):697-708.
2005: Yves Henrotin; B Kurz; Thomas Aigner
Oxygen and reactive oxygen species in cartilage degradation: friends or foes?
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2005;13(8):643-54.
2005: Susanna Müller; Stephan Söder; Andre M Oliveira; Carrie Y Inwards; Thomas Aigner
Type II collagen as specific marker for mesenchymal chondrosarcomas compared to other small cell sarcomas of the skeleton.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2005;18(8):1088-94.
2005: Ina Knerr; Steffen W Schubert; Christina Wich; Kerstin Amann; Thomas Aigner; Tina Vogler; Ronny Jung; Jörg Dötsch; Wolfgang Rascher; Said Hashemolhosseini
Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions.
FEBS letters 2005;579(18):3991-8.
2005: Beate Böhm; Thomas Aigner; Barbara Roy; Thomas A Brodie; Carl P Blobel; Harald Burkhardt
Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling.
Arthritis and rheumatism 2005;52(4):1100-9.
2005: Jannis Constantinidis; Cristopher Bohr; Holger Greess; Thomas Aigner; Johannes Zenk; Emmanuel P Prokopakis; Heinrich Iro
Fat obliteration in paranasal sinuses: a comparative magnetic resonance imaging and histopathologic study.
The Laryngoscope 2005;115(4):717-23.
2005: Ernst Pöschl; A Fidler; B Schmidt; A Kallipolitou; Erik Schmid; Thomas Aigner
DNA methylation is not likely to be responsible for aggrecan down regulation in aged or osteoarthritic cartilage.
Annals of the rheumatic diseases 2005;64(3):477-80.
2005: Elmar Lindhorst; Lydia Wachsmuth; N Kimmig; Ruth X Raiss; Thomas Aigner; L Atley; D Eyre
Increase in degraded collagen type II in synovial fluid early in the rabbit meniscectomy model of osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2005;13(2):139-45.
2005: Stephan Söder; Arnavaz Hakimiyan; David C Rueger; Klaus E Kuettner; Thomas Aigner; Susan Chubinskaya
Antisense inhibition of osteogenic protein 1 disturbs human articular cartilage integrity.
Arthritis and rheumatism 2005;52(2):468-78.
2005: Joachim Saas; Matthias Gebauer; Carsten Jacobi; Jochen Haag; Masaharu Takigawa; Thomas Aigner
The human chondrosarcoma HCS-2/8 cell line is responsive to BMP-7, but not to IL-1beta.
Frontiers in bioscience : a journal and virtual library 2005;10():2027-35.
2005: Matthias Gebauer; Joachim Saas; Jochen Haag; Uwe Dietz; Masaharu Takigawa; Eckart Bartnik; Thomas Aigner
Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage.
Arthritis research & therapy 2005;7(2):R274-84.
2005: Ulrike B Kottler; Anselm Jünemann; Thomas Aigner; Matthias Zenkel; Carmen Rummelt; Ursula Schlötzer-Schrehardt
Comparative effects of TGF-beta 1 and TGF-beta 2 on extracellular matrix production, proliferation, migration, and collagen contraction of human Tenon's capsule fibroblasts in pseudoexfoliation and primary open-angle glaucoma.
Experimental eye research 2005;80(1):121-34.
2005: Zhiyong FAN; Brigitte Bau; Huiqing Yang; Stephan Soeder; Thomas Aigner
Freshly isolated osteoarthritic chondrocytes are catabolically more active than normal chondrocytes, but less responsive to catabolic stimulation with interleukin-1beta.
Arthritis and rheumatism 2005;52(1):136-43.
2005: Susanne Dertinger; Stephan Söeder; Hubert Bösch; Thomas Aigner
Matrix composition of cartilaginous anlagen in achondrogenesis type II (Langer-Saldino).
Frontiers in bioscience : a journal and virtual library 2005;10():446-53.
2004: Cornelius Schörle; Irmgard Verdorfer; Florian Finger; J Block; Erich Gebhart; Thomas Aigner
Comparative analysis of imbalances in genomic DNA and mRNA expression levels in chondrosarcoma-derived cell line FSCP-1.
International journal of oncology 2004;25(6):1651-60.
2004: Sabine Zirlik; Thomas Aigner; Ulrich Baum; Eckhart Hahn; Gunther H Wiest
[Metastatic alveolar soft tissue sarcoma in a 26-year-old patient].
Medizinische Klinik (Munich, Germany : 1983) 2004;99(11):682-3.
2004: Martina Kaiser; Jochen Haag; Stephan Söder; Brigitte Bau; Thomas Aigner
Bone morphogenetic protein and transforming growth factor beta inhibitory Smads 6 and 7 are expressed in human adult normal and osteoarthritic cartilage in vivo and are differentially regulated in vitro by interleukin-1beta.
Arthritis and rheumatism 2004;50(11):3535-40.
2004: J Saas; K Lindauer; B Bau; M Takigawa; Thomas Aigner
Molecular phenotyping of HCS-2/8 cells as an in vitro model of human chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2004;12(11):924-34.
2004: Martin Zenker; Thomas Aigner; Olaf Wendler; Tim Tralau; Horst Müntefering; Regina Fenski; Susanne Pitz; Valerie Schumacher; Brigitte Royer-Pokora; Elke Wühl; Pierre Cochat; Raymonde Bouvier; Cornelia Kraus; Karlheinz Mark; Henry Madlon; Jörg Dötsch; Wolfgang Rascher; Iwona Maruniak-Chudek; Thomas Lennert; Luitgard M Neumann; André Reis
Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities.
Human molecular genetics 2004;13(21):2625-32.
2004: Zhiyong FAN; Brigitte Bau; Huiqing Yang; Thomas Aigner
IL-1beta induction of IL-6 and LIF in normal articular human chondrocytes involves the ERK, p38 and NFkappaB signaling pathways.
Cytokine 2004;28(1):17-24.
2004: Thomas Aigner; Eckart Bartnik; Florian Sohler; Ralf Zimmer
Functional genomics of osteoarthritis: on the way to evaluate disease hypotheses.
Clinical orthopaedics and related research 2004;(427 Suppl):S138-43.
2004: S Duerr; S Stremme; Stephan Soeder; Brigitte Bau; Thomas Aigner
MMP-2/gelatinase A is a gene product of human adult articular chondrocytes and is increased in osteoarthritic cartilage.
Clinical and experimental rheumatology 2004;22(5):603-8.
2004: Lars Morawietz; Thorsten Gehrke; RA Classen; B Barden; M Otto; T Hansen; Thomas Aigner; Peter Stiehl; Jasper Neidel; Jörg Hartmut Schröder; Lars Frommelt; Th Schubert; Carola Meyer-Scholten; A König; Ph Ströbel; Ch P Rader; S Kirschner; F Lintner; Wolfgang Rüther; Adrian Skwara; I Bos; Jörg Kriegsmann; Veit Krenn
[Proposal for the classification of the periprosthetic membrane from loosened hip and knee endoprostheses].
Der Pathologe 2004;25(5):375-84.
2004: Alexander Schuh; Günther Zeiler; Ulrich Holzwarth; Thomas Aigner
Malignant fibrous histiocytoma at the site of a total hip arthroplasty.
Clinical orthopaedics and related research 2004;(425):218-22.
2004: Thomas Aigner; Hyun A Kim; Helmtrud I Roach
Apoptosis in osteoarthritis.
Rheumatic diseases clinics of North America 2004;30(3):639-53, xi.
2004: W Nussbeck; Daniel Neureiter; Stephan Söder; Carrie Y Inwards; Thomas Aigner
Mesenchymal chondrosarcoma: an immunohistochemical study of 10 cases examining prognostic significance of proliferative activity and cellular differentiation.
Pathology 2004;36(3):230-3.
2004: Helmtrud I Roach; Thomas Aigner; J B Kouri
Chondroptosis: a variant of apoptotic cell death in chondrocytes?
Apoptosis : an international journal on programmed cell death 2004;9(3):265-77.
2004: Brigitte Bau; Louise A McKenna; Stephan Soeder; Zhiyong FAN; Anja Pecht; Thomas Aigner
Hepatocyte growth factor/scatter factor is not a potent regulator of anabolic and catabolic gene expression in adult human articular chondrocytes.
Biochemical and biophysical research communications 2004;316(4):984-90.
2004: Thomas Aigner; Florian Finger; Alexander Zien; Eckart Bartnik
[cDNA-microarrays in cartilage research - functional genomics of osteoarthritis].
Zeitschrift für Orthopädie und ihre Grenzgebiete 2004;142(2):241-7.
2004: Lydia Wachsmuth; Brigitte Bau; Zhiyong FAN; Anja Pecht; Nicole Gerwin; Thomas Aigner
ADAMTS-1, a gene product of articular chondrocytes in vivo and in vitro, is downregulated by interleukin 1beta.
The Journal of rheumatology 2004;31(2):315-20.
2004: Thomas Aigner; Andre M Oliveira; Antonio G Nascimento
Extraskeletal myxoid chondrosarcomas do not show a chondrocytic phenotype.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2004;17(2):214-21.
2004: Florian Finger; Cornelius Schörle; Stephan Soder; Alexander Zien; Mary B Goldring; Thomas Aigner
Phenotypic characterization of human chondrocyte cell line C-20/A4: a comparison between monolayer and alginate suspension culture.
Cells, tissues, organs 2004;178(2):65-77.
2004: Thomas Aigner; J Rose; J Martin; J Buckwalter
Aging theories of primary osteoarthritis: from epidemiology to molecular biology.
Rejuvenation research 2004;7(2):134-45.
2004: Stephan Soeder; Alexander Kuhlmann; Thomas Aigner
Analysis of protein distribution in cartilage using immunofluorescence and laser confocal scanning microscopy.
Methods in molecular medicine 2004;101():107-25.
2004: Thomas Aigner; Joachim Saas; Alexander Zien; Ralf Zimmer; Pia Gebhard; Thomas Knorr
Analysis of differential gene expression in healthy and osteoarthritic cartilage and isolated chondrocytes by microarray analysis.
Methods in molecular medicine 2004;100():109-28.
2004: Audrey McAlinden; Jochen Haag; Brigitte Bau; Pia Gebhard; Thomas Aigner
Quantification of mRNA expression levels in articular chondrocytes with PCR technologies.
Methods in molecular medicine 2004;100():79-100.
2004: Zhiyong FAN; Susan Chubinskaya; David C Rueger; Brigitte Bau; Jochen Haag; Thomas Aigner
Regulation of anabolic and catabolic gene expression in normal and osteoarthritic adult human articular chondrocytes by osteogenic protein-1.
Clinical and experimental rheumatology 2004;22(1):103-6.
2004: Pia Gebhard; Stephan Söder; Brigitte Bau; Thomas Aigner
Down-regulation of the GTPase RhoB might be involved in the pre-apoptotic phenotype of osteoarthritic chondrocytes.
Frontiers in bioscience : a journal and virtual library 2004;9():827-33.
2003: Florian Finger; Cornelius Schörle; Alexander Zien; Pia Gebhard; M B Goldring; Thomas Aigner
Molecular phenotyping of human chondrocyte cell lines T/C-28a2, T/C-28a4, and C-28/I2.
Arthritis and rheumatism 2003;48(12):3395-403.
2003: Thomas Aigner; J Stöve
Collagens--major component of the physiological cartilage matrix, major target of cartilage degeneration, major tool in cartilage repair.
Advanced drug delivery reviews 2003;55(12):1569-93.
2003: Kolja Gelse; Ernst Pöschl; Thomas Aigner
Collagens--structure, function, and biosynthesis.
Advanced drug delivery reviews 2003;55(12):1531-46.
2003: Thomas Knorr; F Obermayr; Eckart Bartnik; Alexander Zien; Thomas Aigner
YKL-39 (chitinase 3-like protein 2), but not YKL-40 (chitinase 3-like protein 1), is up regulated in osteoarthritic chondrocytes.
Annals of the rheumatic diseases 2003;62(10):995-8.
2003: Thomas Aigner; Jayesh Dudhia
Genomics of osteoarthritis.
Current opinion in rheumatology 2003;15(5):634-40.
2003: Dieter Schwab; Susanna Müller; Thomas Aigner; Daniel Neureiter; Thomas Kirchner; Eckhart Hahn; Martin Raithel
Functional and morphologic characterization of eosinophils in the lower intestinal mucosa of patients with food allergy.
The American journal of gastroenterology 2003;98(7):1525-34.
2003: Thomas Aigner; Pia Gebhard; Erik Schmid; Brigitte Bau; Vincent Harley; Ernst Pöschl
SOX9 expression does not correlate with type II collagen expression in adult articular chondrocytes.
Matrix biology : journal of the International Society for Matrix Biology 2003;22(4):363-72.
2003: Anja Kassner; Uwe Hansen; Nicolai Miosge; Ehab Ismail El=-Hallous; Thomas Aigner; Leena Bruckner-Tuderman; Peter Bruckner; Susanne Grässel
Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils.
Matrix biology : journal of the International Society for Matrix Biology 2003;22(2):131-43.
2003: Thomas Aigner
Chondrocyte apoptosis in osteoarthritis: comment on the letter by Kouri and Abbud-Lozoya.
Arthritis and rheumatism 2003;48(4):1166-7.
2003: S Stremme; S Duerr; Brigitte Bau; E Schmid; Thomas Aigner
MMP-8 is only a minor gene product of human adult articular chondrocytes of the knee.
Clinical and experimental rheumatology 2003;21(2):205-9.
2003: Thomas Aigner; Ralf Zimmer
The promise and limitations of DNA microarray analysis: comment on the editorial by Firestein and Pisetsky.
Arthritis and rheumatism 2003;48(3):860; author reply 862.
2003: Susanna Müller; D Schwab; Thomas Aigner; Thomas Kirchner
[Allergy-associated colitis. Characterization of an entity and its differential diagnoses].
Der Pathologe 2003;24(1):28-35.
2003: Kolja Gelse; Klaus von der Mark; Thomas Aigner; Jung Park; Holm Schneider
Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells.
Arthritis and rheumatism 2003;48(2):430-41.
2003: Uwe Horas; Dalip Pelinkovic; G Herr; Thomas Aigner; Reinhard Schnettler
Autologous chondrocyte implantation and osteochondral cylinder transplantation in cartilage repair of the knee joint. A prospective, comparative trial.
The Journal of bone and joint surgery. American volume 2003;85-A(2):185-92.
2003: Kolja Gelse; Stephan Söder; Wolfgang Eger; T Diemtar; Thomas Aigner
Osteophyte development--molecular characterization of differentiation stages.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2003;11(2):141-8.
2003: Thomas Aigner; Alexander Zien; Daniel Hanisch; Ralf Zimmer
Gene expression in chondrocytes assessed with use of microarrays.
The Journal of bone and joint surgery. American volume 2003;85-A Suppl 2():117-23.
2003: Rudolf Ott; Cathrin Böhner; Susanna Müller; Thomas Aigner; Michaela Bussenius-Kammerer; Süleyman Yedibela; Hermann Kissler; Werner Hohenberger; Thomas Reck; Volker Müller
Outcome of patients with pre-existing portal vein thrombosis undergoing arterialization of the portal vein during liver transplantation.
Transplant international : official journal of the European Society for Organ Transplantation 2003;16(1):15-20.
2003: Pia Gebhard; Angelika Gehrsitz; Brigitte Bau; Stephan Söder; Wolfgang Eger; Thomas Aigner
Quantification of expression levels of cellular differentiation markers does not support a general shift in the cellular phenotype of osteoarthritic chondrocytes.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2003;21(1):96-101.
2002: Brigitte Bau; Jochen Haag; Erik Schmid; Martina Kaiser; Pia Gebhard; Thomas Aigner
Bone morphogenetic protein-mediating receptor-associated Smads as well as common Smad are expressed in human articular chondrocytes but not up-regulated or down-regulated in osteoarthritic cartilage.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(12):2141-50.
2002: Christoph W Spraul; Martha J Jakobczyk-Zmija; Thomas Aigner; Gerhard K Lang
Posterior fibrous pseudometaplasia of lens epithelial cells in phacic eyes filled with silicone oil.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 2002;240(10):829-34.
2002: Brigitte Bau; Pia Gebhard; Jochen Haag; Thomas Knorr; Eckart Bartnik; Thomas Aigner
Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro.
Arthritis and rheumatism 2002;46(10):2648-57.
2002: Stephan Oehler; Daniel Neureiter; Carola Meyer-Scholten; Thomas Aigner
Subtyping of osteoarthritic synoviopathy.
Clinical and experimental rheumatology 2002;20(5):633-40.
2002: Thomas Aigner
Towards a new understanding and classification of chondrogenic neoplasias of the skeleton--biochemistry and cell biology of chondrosarcoma and its variants.
Virchows Archiv : an international journal of pathology 2002;441(3):219-30.
2002: Thomas Aigner; Eckart Bartnik; Alexander Zien; Ralf Zimmer
Functional genomics of osteoarthritis.
Pharmacogenomics 2002;3(5):635-50.
2002: Thomas Aigner
Apoptosis, necrosis, or whatever: how to find out what really happens?
The Journal of pathology 2002;198(1):1-4.
2002: Thomas Aigner; Bodo Kurz; Naoshi Fukui; Linda Sandell
Roles of chondrocytes in the pathogenesis of osteoarthritis.
Current opinion in rheumatology 2002;14(5):578-84.
2002: Thomas Aigner; H A Kim
Apoptosis and cellular vitality: issues in osteoarthritic cartilage degeneration.
Arthritis and rheumatism 2002;46(8):1986-96.
2002: Cornelius Schörle; KK Unni; Thomas Aigner
[Neoplastic chondroneogenesis as a characteristic of mesenchymal chondrosarcomas].
Der Orthopäde 2002;31(6):544-50.
2002: Stephan Söder; L Hambach; R Lissner; Thomas Kirchner; Thomas Aigner
Ultrastructural localization of type VI collagen in normal adult and osteoarthritic human articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(6):464-70.
2002: Gabriele Lasczkowski; Thomas Aigner; Ulrike Gamerdinger; Günter Weiler; Hansjürgen Bratzke
Visualization of postmortem chondrocyte damage by vital staining and confocal laser scanning 3D microscopy.
Journal of forensic sciences 2002;47(3):663-6.
2002: Thomas Aigner; Susanna Müller; Daniel Neureiter; Duane M Illstrup; Thomas Kirchner; Johannes Björnsson
Prognostic relevance of cell biologic and biochemical features in conventional chondrosarcomas.
Cancer 2002;94(8):2273-81.
2002: Cornelius Schörle; Carrie Y Inwards; KK Unni; Thomas Kirchner; Thomas Aigner
[Characterisation and differentiation of chondroblastomas and chondromyxoidfibromas - presence and expression of collagen types I and II].
Zeitschrift für Orthopädie und ihre Grenzgebiete 2002;140(2):208-13.
2002: Thomas Aigner; L Hambach; Stephan Söder; U Schlötzer-Schrehardt; Ernst Pöschl
The C5 domain of Col6A3 is cleaved off from the Col6 fibrils immediately after secretion.
Biochemical and biophysical research communications 2002;290(2):743-8.
2002: Thomas Aigner; Louise A McKenna
Molecular pathology and pathobiology of osteoarthritic cartilage.
Cellular and molecular life sciences : CMLS 2002;59(1):5-18.
2001: Thomas Aigner; Alexander Zien; Angelika Gehrsitz; Pia Gebhard; Louise A McKenna
Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology.
Arthritis and rheumatism 2001;44(12):2777-89.
2001: Beate Böhm; Thomas Aigner; Carl P Blobel; Joachim R Kalden; Harald Burkhardt
Highly enhanced expression of the disintegrin metalloproteinase MDC15 (metargidin) in rheumatoid synovial tissue.
Arthritis and rheumatism 2001;44(9):2046-54.
2001: Kolja Gelse; Qiu-Jie Jiang; Thomas Aigner; T Ritter; K Wagner; Ernst Pöschl; Klaus von der Mark; Holm Schneider
Fibroblast-mediated delivery of growth factor complementary DNA into mouse joints induces chondrogenesis but avoids the disadvantages of direct viral gene transfer.
Arthritis and rheumatism 2001;44(8):1943-53.
2001: Stephan Söder; Carrie Y Inwards; Susanna Müller; Thomas Kirchner; Thomas Aigner
Cell biology and matrix biochemistry of chondromyxoid fibroma.
American journal of clinical pathology 2001;116(2):271-7.
2001: Thomas Aigner; M Hemmel; Daniel Neureiter; Pia Gebhard; Günther Zeiler; Thomas Kirchner; Louise A McKenna
Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage: a study of proliferation, programmed cell death (apoptosis), and viability of chondrocytes in normal and osteoarthritic human knee cartilage.
Arthritis and rheumatism 2001;44(6):1304-12.
2001: S Müller; Daniel Neureiter; Manfred Stolte; C Verbeke; Peter U Heuschmann; Thomas Kirchner; Thomas Aigner
Tenascin: a sensitive and specific diagnostic marker of minimal collagenous colitis.
Virchows Archiv : an international journal of pathology 2001;438(5):435-41.
2001: Angelika Gehrsitz; Louise A McKenna; Stephan Söder; Thomas Kirchner; Thomas Aigner
Isolation of RNA from small human articular cartilage specimens allows quantification of mRNA expression levels in local articular cartilage defects.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2001;19(3):478-81.
2001: D Gottschalk; M Fehn; S Patt; Wolfgang Saeger; Thomas Kirchner; Thomas Aigner
Matrix gene expression analysis and cellular phenotyping in chordoma reveals focal differentiation pattern of neoplastic cells mimicking nucleus pulposus development.
The American journal of pathology 2001;158(5):1571-8.
2001: L J Sandell; Thomas Aigner
Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis.
Arthritis research 2001;3(2):107-13.
2000: Louise A McKenna; Angelika Gehrsitz; Stephan Söder; Wolfgang Eger; Thomas Kirchner; Thomas Aigner
Effective isolation of high-quality total RNA from human adult articular cartilage.
Analytical biochemistry 2000;286(1):80-5.
2000: Thomas Aigner; S Loos; Susanna Müller; L J Sandell; KK Unni; Thomas Kirchner
Cell differentiation and matrix gene expression in mesenchymal chondrosarcomas.
The American journal of pathology 2000;156(4):1327-35.
2000: Stephan Oehler; HG Fassbender; Daniel Neureiter; Carola Meyer-Scholten; Thomas Kirchner; Thomas Aigner
Cell populations involved in pigmented villonodular synovitis of the knee.
The Journal of rheumatology 2000;27(2):463-70.
2000: Gerald Niedobitek; Renate Lisner; Bernd Swoboda; N Rooney; HG Fassbender; Thomas Kirchner; Thomas Aigner; Hermann Herbst
Lack of evidence for an involvement of Epstein-Barr virus infection of synovial membranes in the pathogenesis of rheumatoid arthritis.
Arthritis and rheumatism 2000;43(1):151-4.
1999: Thomas Aigner; S Loos; Carrie Y Inwards; Roberto Perris; Daniela Perissinotto; KK Unni; Thomas Kirchner
Chondroblastoma is an osteoid-forming, but not cartilage-forming neoplasm.
The Journal of pathology 1999;189(4):463-9.
1999: Thomas Aigner; K K Unni
Is dedifferentiated chondrosarcoma a 'de-differentiated' chondrosarcoma?
The Journal of pathology 1999;189(4):445-7.
1999: Daniel Neureiter; J Böhmer; Thomas Kirchner; Thomas Aigner
Pleomorphic adenomas of the parotid express different mesenchymal phenotypes: demonstration of matrix gene expression products characteristic of the fibroblastic and chondrocytic cell lineages.
Histopathology 1999;35(4):373-9.
1999: Beate Böhm; Thomas Aigner; Angelika Gehrsitz; Carl P Blobel; Joachim R Kalden; Harald Burkhardt
Up-regulation of MDC15 (metargidin) messenger RNA in human osteoarthritic cartilage.
Arthritis and rheumatism 1999;42(9):1946-50.
1999: Thomas Aigner; Y Zhu; H H Chansky; F A Matsen; W J Maloney; L J Sandell
Reexpression of type IIA procollagen by adult articular chondrocytes in osteoarthritic cartilage.
Arthritis and rheumatism 1999;42(7):1443-50.
1998: Thomas Aigner; Daniel Neureiter; U Völker; J Belke; Thomas Kirchner
Epithelial-mesenchymal transdifferentiation and extracellular matrix gene expression in pleomorphic adenomas of the parotid salivary gland.
The Journal of pathology 1998;186(2):178-85.
1998: Thomas Aigner; K R Gresk-otter; J C Fairbank; Klaus von der Mark; Jill P G Urban
Variation with age in the pattern of type X collagen expression in normal and scoliotic human intervertebral discs.
Calcified tissue international 1998;63(3):263-8.
1998: Thomas Aigner; S Dertinger; Daniel Neureiter; Thomas Kirchner
De-differentiated chondrosarcoma is not a 'de-differentiated' chondrosarcoma.
Histopathology 1998;33(1):11-9.
1998: L Hambach; Daniel Neureiter; Günther Zeiler; Thomas Kirchner; Thomas Aigner
Severe disturbance of the distribution and expression of type VI collagen chains in osteoarthritic articular cartilage.
Arthritis and rheumatism 1998;41(6):986-96.
1998: Thomas Aigner; S Oehler; H G Niedobitek; G Fassbender; Thomas Kirchner
[Iron deposits, cell populations and proliferative activity in pigmented villonodular synovitis of the knee joint].
Verhandlungen der Deutschen Gesellschaft für Pathologie 1998;82():327-31.
1998: Thomas Aigner; C C Unni; J Bjornsson; Thomas Kirchner
[Matrix gene expression pattern as indicators of the biology of cartilage-forming tumors].
Verhandlungen der Deutschen Gesellschaft für Pathologie 1998;82():178-83.
1998: B Rahfoth; Jürgen Weisser; F Sternkopf; Thomas Aigner; Klaus von der Mark; Rolf Bräuer
Transplantation of allograft chondrocytes embedded in agarose gel into cartilage defects of rabbits.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6(1):50-65.
1997: Thomas Aigner; Daniel Neureiter; S Müller; G Küspert; J Belke; Thomas Kirchner
Extracellular matrix composition and gene expression in collagenous colitis.
Gastroenterology 1997;113(1):136-43.
1997: Thomas Aigner; S Frischholz; S Dertinger; Frank Beier; I Girkontaité; Klaus von der Mark
Type X collagen expression and hypertrophic differentiation in chondrogenic neoplasias.
Histochemistry and cell biology 1997;107(6):435-40.
1997: Thomas Aigner; S Dertinger; SI Vornehm; Jayesh Dudhia; Klaus von der Mark; Thomas Kirchner
Phenotypic diversity of neoplastic chondrocytes and extracellular matrix gene expression in cartilaginous neoplasms.
The American journal of pathology 1997;150(6):2133-41.
1997: Thomas Aigner; K Glückert; Klaus von der Mark
Activation of fibrillar collagen synthesis and phenotypic modulation of chondrocytes in early human osteoarthritic cartilage lesions.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1997;5(3):183-9.
1997: Thomas Aigner; Jayesh Dudhia
Phenotypic modulation of chondrocytes as a potential therapeutic target in osteoarthritis: a hypothesis.
Annals of the rheumatic diseases 1997;56(5):287-91.
1997: Thomas Aigner; SI Vornehm; Günther Zeiler; Jayesh Dudhia; Klaus von der Mark; Michael T Bayliss
Suppression of cartilage matrix gene expression in upper zone chondrocytes of osteoarthritic cartilage.
Arthritis and rheumatism 1997;40(3):562-9.
1997: Antje Bornemann; Thomas Aigner; Thomas Kirchner
Spatial and temporal development of the gliovascular tissue in type II lissencephaly.
Acta neuropathologica 1997;93(2):173-7.
1996: Thomas Aigner; S Dertinger; J Belke; Thomas Kirchner
Chondrocytic cell differentiation in clear cell chondrosarcoma.
Human pathology 1996;27(12):1301-5.
1996: Irute Girkontaite; S Frischholz; P Lammi; K Wagner; Bernd Swoboda; Thomas Aigner; Klaus von der Mark
Immunolocalization of type X collagen in normal fetal and adult osteoarthritic cartilage with monoclonal antibodies.
Matrix biology : journal of the International Society for Matrix Biology 1996;15(4):231-8.
1996: S I Vornehm; Jayesh Dudhia; Klaus von der Mark; Thomas Aigner
Expression of collagen types IX and XI and other major cartilage matrix components by human fetal chondrocytes in vivo.
Matrix biology : journal of the International Society for Matrix Biology 1996;15(2):91-8.
1996: J Dürr; P Lammi; S L Goodman; Thomas Aigner; Klaus von der Mark
Identification and immunolocalization of laminin in cartilage.
Experimental cell research 1996;222(1):225-33.
1996: Thomas Aigner; S I Vornehm; J Belke; Klaus von der Mark; Thomas Kirchner
[Inflammatory cytokine mediated anti-anabolic effects: a potential mechanism in rheumatoid cartilage degeneration].
Verhandlungen der Deutschen Gesellschaft für Pathologie 1996;80():282-7.
1995: Klaus von der Mark; S Frischholz; Thomas Aigner; F Beier; J Belke; S Erdmann; Harald Burkhardt
Upregulation of type X collagen expression in osteoarthritic cartilage.
Acta orthopaedica Scandinavica. Supplementum 1995;266():125-9.
1995: Thomas Aigner; U Dietz; H Stöss; Klaus von der Mark
Differential expression of collagen types I, II, III, and X in human osteophytes.
Laboratory investigation; a journal of technical methods and pathology 1995;73(2):236-43.
1995: Raimund W Kinne; S Boehm; T Iftner; Thomas Aigner; S Vornehm; G Weseloh; R Bravo; Frank Emmrich; Richard A Kroczek
Synovial fibroblast-like cells strongly express jun-B and C-fos proto-oncogenes in rheumatoid- and osteoarthritis.
Scandinavian journal of rheumatology. Supplement 1995;101():121-5.
1994: U P Rausch; M Jordan; F Rödel; Thomas Aigner; I G Otterness; N Beuscher; Martin Röllinghoff; H Ulrich Beuscher
Transcriptional and translational regulation of IL-1 alpha and IL-1 beta account for the control of IL-1 in experimental yersiniosis.
Cytokine 1994;6(5):504-11.
1993: U Dietz; Thomas Aigner; W M Bertling; Klaus von der Mark
Alterations of collagen mRNA expression during retinoic acid induced chondrocyte modulation: absence of untranslated alpha 1(I) mRNA in hyaline chondrocytes.
Journal of cellular biochemistry 1993;52(1):57-68.
1993: Thomas Aigner; W Bertling; H Stöss; G Weseloh; Klaus von der Mark
Independent expression of fibril-forming collagens I, II, and III in chondrocytes of human osteoarthritic cartilage.
The Journal of clinical investigation 1993;91(3):829-37.
1993: Thomas Aigner; E Reichenberger; W Bertling; Thorsten Kirsch; H Stöss; Klaus von der Mark
Type X collagen expression in osteoarthritic and rheumatoid articular cartilage.
Virchows Archiv. B, Cell pathology including molecular pathology 1993;63(4):205-11.
1992: B Böhm; Thomas Aigner; Rolf Kinne; Harald Burkhardt
The serine-protease inhibitor of cartilage matrix is not a chondrocytic gene product.
European journal of biochemistry / FEBS 1992;207(2):773-9.
1992: Thomas Aigner; H Stöss; G Weseloh; Günther Zeiler; Klaus von der Mark
Activation of collagen type II expression in osteoarthritic and rheumatoid cartilage.
Virchows Archiv. B, Cell pathology including molecular pathology 1992;62(6):337-45.
1991: E Reichenberger; Thomas Aigner; Klaus von der Mark; H Stöss; W Bertling
In situ hybridization studies on the expression of type X collagen in fetal human cartilage.
Developmental biology 1991;148(2):562-72.