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Nicholas Tonks

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TOP 3
Nicholas K Tonks
Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction.
Min Yu; Francis Nguyen; Nicholas K Tonks; Bin Xue; Niloofar Arshadi; Paul C Boutros; Ari Elson; Syed Haider; Irina Kalatskaya; Guang Lin; Lakshmi B Muthuswamy; Senthil K Muthuswamy
Expression profiling during mammary epithelial cell three-dimensional morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2-mediated transformation.
Xiaoqun Catherine Zhang; Linda Van Aelst; Michael P Myers; Antonella Piccini; Nicholas K Tonks
Functional analysis of the protein phosphatase activity of PTEN.

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All Publications

2013: Nicholas K Tonks
Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction.
The FEBS journal 2013;280(2):346-78.
2012: Min Yu; Francis Nguyen; Nicholas K Tonks; Bin Xue; Niloofar Arshadi; Paul C Boutros; Ari Elson; Syed Haider; Irina Kalatskaya; Guang Lin; Lakshmi B Muthuswamy; Senthil K Muthuswamy
Expression profiling during mammary epithelial cell three-dimensional morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2-mediated transformation.
Molecular and cellular biology 2012;32(19):3913-24.
2012: Xiaoqun Catherine Zhang; Linda Van Aelst; Michael P Myers; Antonella Piccini; Nicholas K Tonks
Functional analysis of the protein phosphatase activity of PTEN.
The Biochemical journal 2012;444(3):457-64.
2011: Aftabul Haque; Annette Salmeen; jannik andersen; David Barford; Nicholas K Tonks
Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity.
Cell 2011;147(1):185-98.
2011: Sang Won Hyun; Erik Lillehoj; Anguo Liu; Antonino Passaniti; John D Sorkin; Nicholas K Tonks; Shiqi Yang; Ian E Anglin; Simeon E Goldblum
Diverse injurious stimuli reduce protein tyrosine phosphatase-μ expression and enhance epidermal growth factor receptor signaling in human airway epithelia.
Experimental lung research 2011;37(6):327-43.
2010: Ulla Schwertassek; Deirdre Buckley; Chong-Feng Xu; Andrew J Lindsay; Mary W McCaffrey; Thomas A Neubert; Nicholas K Tonks
Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis.
The FEBS journal 2010;277(11):2463-73.
2010: Shantá D Hinton; Michael P Myers; Vincent R Roggero; Lizabeth A Allison; Nicholas K Tonks
The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation.
The Biochemical journal 2010;427(3):349-57.
2010: Benoit Boivin; Ming Yang; Nicholas K Tonks
Targeting the reversibly oxidized protein tyrosine phosphatase superfamily.
Science signaling 2010;3(137):pl2.
2010: Benoit Boivin; Nicholas K Tonks
Analysis of the redox regulation of protein tyrosine phosphatase superfamily members utilizing a cysteinyl-labeling assay.
Methods in enzymology 2010;474():35-50.
2009: Nicholas K Tonks
Pseudophosphatases: grab and hold on.
Cell 2009;139(3):464-5.
2009: Kim Loh; Haiyang Deng; Atsushi Fukushima; Xiaochu Cai; Benoit Boivin; Sandra Galic; Clinton Bruce; Benjamin J Shields; Beata Skiba; Lisa M Ooms; Nigel Stepto; Ben Wu; Christina A Mitchell; Nicholas K Tonks; Matthew J Watt; Mark A Febbraio; Peter J Crack; Sofianos Andrikopoulos; Tony Tiganis
Reactive oxygen species enhance insulin sensitivity.
Cell metabolism 2009;10(4):260-72.
2008: Benoit Boivin; Sheng Zhang; Jack L Arbiser; Zhong-Yin Zhang; Nicholas K Tonks
A modified cysteinyl-labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(29):9959-64.
2008: Yi-Wei Lou; Yi-Yun Chen; Shu-Fan Hsu; Ren-Kun Chen; Chih-Lei Lee; Kay-Hooi Khoo; Nicholas K Tonks; Tzu-Ching Meng
Redox regulation of the protein tyrosine phosphatase PTP1B in cancer cells.
The FEBS journal 2008;275(1):69-88.
2007: Nicholas K Tonks; Senthil K Muthuswamy
A brake becomes an accelerator: PTP1B--a new therapeutic target for breast cancer.
Cancer cell 2007;11(3):214-6.
2006: Nicholas K Tonks
Protein tyrosine phosphatases: from genes, to function, to disease.
Nature reviews. Molecular cell biology 2006;7(11):833-46.
2006: Kristin K Nelson; Sita Subbaram; Kip M Connor; Jaya Dasgupta; Xiao-Fang Ha; Tzu-Ching Meng; Nicholas K Tonks; J Andres Melendez
Redox-dependent matrix metalloproteinase-1 expression is regulated by JNK through Ets and AP-1 promoter motifs.
The Journal of biological chemistry 2006;281(20):14100-10.
2005: Nicholas K Tonks
Redox redux: revisiting PTPs and the control of cell signaling.
Cell 2005;121(5):667-70.
2005: Xiu Fen Sui; Timothy D Kiser; Sang Won Hyun; Daniel Angelini; Robert L Del Vecchio; Bradford A Young; Jeffrey D Hasday; Lewis H Romer; Antonino Passaniti; Nicholas K Tonks; Simeon E Goldblum
Receptor protein tyrosine phosphatase micro regulates the paracellular pathway in human lung microvascular endothelia.
The American journal of pathology 2005;166(4):1247-58.
2005: Robert L Del Vecchio; Nicholas K Tonks
The conserved immunoglobulin domain controls the subcellular localization of the homophilic adhesion receptor protein-tyrosine phosphatase mu.
The Journal of biological chemistry 2005;280(2):1603-12.
2005: Sandra Galic; Christine Hauser; Barbara B Kahn; Fawaz G Haj; Benjamin G Neel; Nicholas K Tonks; Tony Tiganis
Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP.
Molecular and cellular biology 2005;25(2):819-29.
2005: jannik andersen; Robert L Del Vecchio; Natarajan Kannan; James Gergel; Andrew F. Neuwald; Nicholas K Tonks
Computational analysis of protein tyrosine phosphatases: practical guide to bioinformatics and data resources.
Methods (San Diego, Calif.) 2005;35(1):90-114.
2005: Tzu-Ching Meng; Shu-Fang Hsu; Nicholas K Tonks
Development of a modified in-gel assay to identify protein tyrosine phosphatases that are oxidized and inactivated in vivo.
Methods (San Diego, Calif.) 2005;35(1):28-36.
2004: Hsu-Hsin Chen; Ralf Luche; Bo Wei; Nicholas K Tonks
Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2.
The Journal of biological chemistry 2004;279(40):41404-13.
2004: Tzu-Ching Meng; Deirdre Buckley; Sandra Galic; Tony Tiganis; Nicholas K Tonks
Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B.
The Journal of biological chemistry 2004;279(36):37716-25.
2004: Patricia Bukczynska; Manuela Klingler-Hoffmann; Kenneth I Mitchelhill; Mark H C Lam; Melissa Ciccomancini; Nicholas K Tonks; Boris Sarcevic; Bruce E Kemp; Tony Tiganis
The T-cell protein tyrosine phosphatase is phosphorylated on Ser-304 by cyclin-dependent protein kinases in mitosis.
The Biochemical journal 2004;380(Pt 3):939-49.
2004: jannik andersen; Peter G Jansen; Søren M Echwald; Ole H Mortensen; Toshiyuki Fukada; Robert L Del Vecchio; Nicholas K Tonks; Niels Peter H Møller
A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(1):8-30.
2003: Josema Torres; Joe Rodriguez; Michael P Myers; Miguel Valiente; Jonathan D Graves; Nicholas K Tonks; Rafael Pulido
Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions.
The Journal of biological chemistry 2003;278(33):30652-60.
2003: Christopher H Gray; Valerie M Good; Nicholas K Tonks; David Barford
The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase.
The EMBO journal 2003;22(14):3524-35.
2003: Nicholas K Tonks
PTP1B: from the sidelines to the front lines!
FEBS letters 2003;546(1):140-8.
2003: Annette Salmeen; jannik andersen; Michael P Myers; Tzu-Ching Meng; John A Hinks; Nicholas K Tonks; David Barford
Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate.
Nature 2003;423(6941):769-73.
2003: Sandra Galic; Manuela Klingler-Hoffmann; Michelle T Fodero-Tavoletti; Michelle A Puryer; Tzu-Ching Meng; Nicholas K Tonks; Tony Tiganis
Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP.
Molecular and cellular biology 2003;23(6):2096-108.
2003: Helena L. Palka-Hamblin; Morag Park; Nicholas K Tonks
Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1.
The Journal of biological chemistry 2003;278(8):5728-35.
2003: Toshiyuki Fukada; Nicholas K Tonks
Identification of YB-1 as a regulator of PTP1B expression: implications for regulation of insulin and cytokine signaling.
The EMBO journal 2003;22(3):479-93.
2003: Tzu-Ching Meng; Nicholas K Tonks
Analysis of the regulation of protein tyrosine phosphatases in vivo by reversible oxidation.
Methods in enzymology 2003;366():304-18.
2002: Robert J Harrington; Michael J Gutch; Michael O. Hengartner; Nicholas K Tonks; Andrew D Chisholm
The C. elegans LAR-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph receptor tyrosine kinase have partly redundant functions in morphogenesis.
Development (Cambridge, England) 2002;129(9):2141-53.
2002: Lindsey D Mayo; Jack E Dixon; Donald L Durden; Nicholas K Tonks; David B Donner
PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy.
The Journal of biological chemistry 2002;277(7):5484-9.
2002: Tzu-Ching Meng; Toshiyuki Fukada; Nicholas K Tonks
Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo.
Molecular cell 2002;9(2):387-99.
2001: Michael P Myers; jannik andersen; A Cheng; M L Tremblay; Curt M Horvath; Jean-Patrick Parisien; Annette Salmeen; David Barford; Nicholas K Tonks
TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B.
The Journal of biological chemistry 2001;276(51):47771-4.
2001: Y Shen; R Luche; B Wei; M L Gordon; C D Diltz; Nicholas K Tonks
Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13613-8.
2001: jannik andersen; O H Mortensen; Günther H Peters; P G Drake; Lars F Iversen; Ole H Olsen; P G Jansen; Henrik Sune Andersen; Nicholas K Tonks; Niels Peter H Møller
Structural and evolutionary relationships among protein tyrosine phosphatase domains.
Molecular and cellular biology 2001;21(21):7117-36.
2001: Mark H C Lam; Belinda J Michell; Michelle T Fodero-Tavoletti; Bruce E Kemp; Nicholas K Tonks; Tony Tiganis
Cellular stress regulates the nucleocytoplasmic distribution of the protein-tyrosine phosphatase TCPTP.
The Journal of biological chemistry 2001;276(40):37700-7.
2001: Jing Yang; Pawel Dokurno; Nicholas K Tonks; David Barford
Crystal structure of the M-fragment of alpha-catenin: implications for modulation of cell adhesion.
The EMBO journal 2001;20(14):3645-56.
2001: Toshiyuki Fukada; Nicholas K Tonks
The reciprocal role of Egr-1 and Sp family proteins in regulation of the PTP1B promoter in response to the p210 Bcr-Abl oncoprotein-tyrosine kinase.
The Journal of biological chemistry 2001;276(27):25512-9.
2001: S Wen; JP Stolarov; Michael P Myers; Jing Dong Su; Michael Wigler; Nicholas K Tonks; Donald L Durden
PTEN controls tumor-induced angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4622-7.
2000: Annette Salmeen; jannik andersen; Michael P Myers; Nicholas K Tonks; David Barford
Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.
Molecular cell 2000;6(6):1401-12.
1999: Nicholas K Tonks; Michael P Myers
Structural assets of a tumor suppressor.
Science (New York, N.Y.) 1999;286(5447):2096-7.
1999: Tony Tiganis; Bruce E Kemp; Nicholas K Tonks
The protein-tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and phosphatidylinositol 3-kinase-dependent signaling.
The Journal of biological chemistry 1999;274(39):27768-75.
1999: S H Zhang; J Liu; Ryuji Kobayashi; Nicholas K Tonks
Identification of the cell cycle regulator VCP (p97/CDC48) as a substrate of the band 4.1-related protein-tyrosine phosphatase PTPH1.
The Journal of biological chemistry 1999;274(25):17806-12.
1999: A J Garton; Nicholas K Tonks
Regulation of fibroblast motility by the protein tyrosine phosphatase PTP-PEST.
The Journal of biological chemistry 1999;274(6):3811-8.
1998: Jing Li; Laura Simpson; M Takahashi; C Miliaresis; M P Myers; Nicholas K Tonks; Ramon Parsons
The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene.
Cancer research 1998;58(24):5667-72.
1998: K R LaMontagne; Gregory J Hannon; Nicholas K Tonks
Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of rat-1 fibroblasts and promotes differentiation of K562 cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14094-9.
1998: Michael P Myers; Ian Pass; Ian H Batty; Jeroen van der Kaay; JP Stolarov; B A Hemmings; Michael Wigler; C Peter Downes; Nicholas K Tonks
The lipid phosphatase activity of PTEN is critical for its tumor supressor function.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13513-8.
1998: K R LaMontagne; AJ Flint; B R Franza; A M Pandergast; Nicholas K Tonks
Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo.
Molecular and cellular biology 1998;18(5):2965-75.
1998: A D Pannifer; AJ Flint; Nicholas K Tonks; David Barford
Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography.
The Journal of biological chemistry 1998;273(17):10454-62.
1998: Tony Tiganis; A M Bennett; Kodi S Ravichandran; Nicholas K Tonks
Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase.
Molecular and cellular biology 1998;18(3):1622-34.
1998: M J Gutch; AJ Flint; J Keller; Nicholas K Tonks; Michael O. Hengartner
The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development.
Genes & development 1998;12(4):571-85.
1997: Michael P Myers; Nicholas K Tonks
PTEN: sometimes taking it off can be better than putting it on.
American journal of human genetics 1997;61(6):1234-8.
1997: L Hao; Tony Tiganis; Nicholas K Tonks; Harry Charbonneau
The noncatalytic C-terminal segment of the T cell protein tyrosine phosphatase regulates activity via an intramolecular mechanism.
The Journal of biological chemistry 1997;272(46):29322-9.
1997: A M Bennett; Nicholas K Tonks
Regulation of distinct stages of skeletal muscle differentiation by mitogen-activated protein kinases.
Science (New York, N.Y.) 1997;278(5341):1288-91.
1997: K M Hoffmann; Nicholas K Tonks; David Barford
The crystal structure of domain 1 of receptor protein-tyrosine phosphatase mu.
The Journal of biological chemistry 1997;272(44):27505-8.
1997: S H Zhang; Ryuji Kobayashi; P R Graves; Helen Piwnica-Worms; Nicholas K Tonks
Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein.
The Journal of biological chemistry 1997;272(43):27281-7.
1997: Tony Tiganis; AJ Flint; Stephen Adam; Nicholas K Tonks
Association of the T-cell protein tyrosine phosphatase with nuclear import factor p97.
The Journal of biological chemistry 1997;272(34):21548-57.
1997: Michael P Myers; JP Stolarov; Charis Eng; Jing Li; SI Wang; Michael Wigler; Ramon Parsons; Nicholas K Tonks
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9052-7.
1997: A J Garton; MR Burnham; Amy H Bouton; Nicholas K Tonks
Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition.
Oncogene 1997;15(8):877-85.
1997: AJ Flint; Tony Tiganis; David Barford; Nicholas K Tonks
Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1680-5.
1996: Nicholas K Tonks; B G Neel
From form to function: signaling by protein tyrosine phosphatases.
Cell 1996;87(3):365-8.
1996: A J Garton; A J Flint; Nicholas K Tonks
Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST.
Molecular and cellular biology 1996;16(11):6408-18.
1996: C Y Park; K R LaMontagne; Nicholas K Tonks; M J Hayman
Cloning and expression of the chicken protein tyrosine phosphatase SH-PTP2.
Gene 1996;177(1-2):93-7.
1995: Susann M Brady-Kalnay; Nicholas K Tonks
Protein tyrosine phosphatases as adhesion receptors.
Current opinion in cell biology 1995;7(5):650-7.
1995: S H Zhang; W R Eckberg; Q Yang; A A Samatar; Nicholas K Tonks
Biochemical characterization of a human band 4.1-related protein-tyrosine phosphatase, PTPH1.
The Journal of biological chemistry 1995;270(34):20067-72.
1995: Susann M Brady-Kalnay; D L Rimm; Nicholas K Tonks
Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo.
The Journal of cell biology 1995;130(4):977-86.
1995: Z Jia; David Barford; AJ Flint; Nicholas K Tonks
Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B.
Science (New York, N.Y.) 1995;268(5218):1754-8.
1994: Susann M Brady-Kalnay; Nicholas K Tonks
Identification of the homophilic binding site of the receptor protein tyrosine phosphatase PTP mu.
The Journal of biological chemistry 1994;269(45):28472-7.
1994: R L Del Vecchio; Nicholas K Tonks
Characterization of two structurally related Xenopus laevis protein tyrosine phosphatases with homology to lipid-binding proteins.
The Journal of biological chemistry 1994;269(30):19639-45.
1994: David Barford; AJ Flint; Nicholas K Tonks
Crystal structure of human protein tyrosine phosphatase 1B.
Science (New York, N.Y.) 1994;263(5152):1397-404.
1994: Susann M Brady-Kalnay; Nicholas K Tonks
Protein tyrosine phosphatases: from structure to function.
Trends in cell biology 1994;4(3):73-6.
1993: H Sun; C H Charles; Lester F Lau; Nicholas K Tonks
MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo.
Cell 1993;75(3):487-93.
1993: Susann M Brady-Kalnay; Nicholas K Tonks
Purification and characterization of the human protein tyrosine phosphatase, PTP mu, from a baculovirus expression system.
Molecular and cellular biochemistry 1993;127-128():131-41.
1993: Q Yang; D Co; J Sommercorn; Nicholas K Tonks
Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase.
The Journal of biological chemistry 1993;268(23):17650.
1993: Susann M Brady-Kalnay; A J Flint; Nicholas K Tonks
Homophilic binding of PTP mu, a receptor-type protein tyrosine phosphatase, can mediate cell-cell aggregation.
The Journal of cell biology 1993;122(4):961-72.
1993: C H Charles; H Sun; Lester F Lau; Nicholas K Tonks
The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5292-6.
1993: Q Yang; D Co; J Sommercorn; Nicholas K Tonks
Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase.
The Journal of biological chemistry 1993;268(9):6622-8.
1992: Nicholas K Tonks; Q Yang; A J Flint; M F Gebbink; B R Franza; David E Hill; H Sun; Susann M Brady-Kalnay
Protein tyrosine phosphatases: the problems of a growing family.
Cold Spring Harbor symposia on quantitative biology 1992;57():87-94.
1992: H Charbonneau; Nicholas K Tonks
1002 protein phosphatases?
Annual review of cell biology 1992;8():463-93.
1991: Nicholas K Tonks; Q Yang; P Guida
Structure, regulation, and function of protein tyrosine phosphatases.
Cold Spring Harbor symposia on quantitative biology 1991;56():265-73.
1990: K L Gould; S Moreno; Nicholas K Tonks; Paul Nurse
Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase.
Science (New York, N.Y.) 1990;250(4987):1573-6.
1990: Nicholas K Tonks
Protein phosphatases: key players in the regulation of cell function.
Current opinion in cell biology 1990;2(6):1114-24.