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Peter Tontonoz
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Chemicals & Drugs
Living Beings
Anatomy
Physiology
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Network (preview)
19
Joseph, Sean
16
Castrillo, Antonio
14
Laffitte, Bryan
12
Pei, Liming
10
Wilpitz, Damien
9
Bradley, Michelle
8
Mangelsdorf, David
7
Edwards, Peter
7
Evans, Ronald
7
Chen, Mingyi
7
Waki, Hironori
7
Walczak, Robert
6
Zelcer, Noam
5
Saez, Enrique
5
Collins, Jon
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All Publications
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2009: Kim Woo-Kyun; Meliton Vicente; Park Kye Won; Hong Cynthia; Tontonoz Peter; Niewiadomski Pawel; Waschek James A; Tetradis Sotirios; Parhami Farhad
Negative regulation of Hedgehog signaling by liver X receptors.
Molecular endocrinology (Baltimore, Md.) 2009;23(10):1532-43.
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2009: A-Gonzalez Noelia; Bensinger Steven J; Hong Cynthia; Beceiro Susana; Bradley Michelle N; Zelcer Noam; Deniz Jose; Ramirez Cristina; Díaz Mercedes; Gallardo German; de Galarreta Carlos Ruiz; Salazar Jon; Lopez Felix; Edwards Peter; Parks John; Andujar Miguel; Tontonoz Peter; Castrillo Antonio
Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.
Immunity 2009;31(2):245-58.
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2009: Zelcer Noam; Hong Cynthia; Boyadjian Rima; Tontonoz Peter
LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor.
Science (New York, N.Y.) 2009;325(5936):100-4.
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2009: Park Kye Won; Waki Hironori; Kim Woo-Kyun; Davies Brandon S J; Young Stephen G; Parhami Farhad; Tontonoz Peter
The small molecule phenamil induces osteoblast differentiation and mineralization.
Molecular and cellular biology 2009;29(14):3905-14.
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2009: Dean Jason T; Tran Linh; Beaven Simon; Tontonoz Peter; Reue Karen; Dipple Katrina M; Liao James C
Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt.
Cell metabolism 2009;9(6):525-36.
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2009: Bensinger Steven J; Tontonoz Peter
A Nurr1 pathway for neuroprotection.
Cell 2009;137(1):26-8.
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2009: Hsu Jeffrey J; Lu Jinxiu; Huang Michael S; Geng Yifan; Sage Andrew P; Bradley Michelle N; Tontonoz Peter; Demer Linda L; Tintut Yin
T0901317, an LXR agonist, augments PKA-induced vascular cell calcification.
FEBS letters 2009;583(8):1344-8.
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2009: Marathe Chaitra; Bradley Michelle N; Hong Cynthia; Chao Lily; Wilpitz Damien; Salazar Jon; Tontonoz Peter
Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/- bone marrow.
Journal of lipid research 2009;50(2):214-24.
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2008: Park Kye Won; Halperin Daniel S; Tontonoz Peter
Before they were fat: adipocyte progenitors.
Cell metabolism 2008;8(6):454-7.
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2008: Chao Lily C; Bensinger Steven J; Villanueva Claudio J; Wroblewski Kevin; Tontonoz Peter
Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1.
Molecular endocrinology (Baltimore, Md.) 2008;22(12):2596-608.
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2008: Hummasti Sarah; Hong Cynthia; Bensinger Steven J; Tontonoz Peter
HRASLS3 is a PPARgamma-selective target gene that promotes adipocyte differentiation.
Journal of lipid research 2008;49(12):2535-44.
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2008: Naiki Yoshikazu; Sorrentino Rosalinda; Wong Michelle H; Michelsen Kathrin S; Shimada Kenichi; Chen Shuang; Yilmaz Atilla; Slepenkin Anatoly; Schröder Nicolas W J; Crother Timothy R; Bulut Yonca; Doherty Terence M; Bradley Michelle; Shaposhnik Zory; Peterson Ellena M; Tontonoz Peter; Shah Prediman K; Arditi Moshe
TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):7176-85.
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2008: Davies Brandon S J; Waki Hironori; Beigneux Anne P; Farber Emily; Weinstein Michael M; Wilpitz Damien C; Tai Li-Jung; Evans Ronald M; Fong Loren G; Tontonoz Peter; Young Stephen G
The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma.
Molecular endocrinology (Baltimore, Md.) 2008;22(11):2496-504.
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2008: Hong Cynthia; Tontonoz Peter
Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors.
Current opinion in genetics & development 2008;18(5):461-7.
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2008: Park Kye Won; Waki Hironori; Villanueva Claudio J; Monticelli Laurel A; Hong Cynthia; Kang Sona; MacDougald Ormond A; Goldrath Ananda W; Tontonoz Peter
Inhibitor of DNA binding 2 is a small molecule-inducible modulator of peroxisome proliferator-activated receptor-gamma expression and adipocyte differentiation.
Molecular endocrinology (Baltimore, Md.) 2008;22(9):2038-48.
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2008: Hummasti Sarah; Tontonoz Peter
Adopting new orphans into the family of metabolic regulators.
Molecular endocrinology (Baltimore, Md.) 2008;22(8):1743-53.
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2008: Bensinger Steven J; Tontonoz Peter
Integration of metabolism and inflammation by lipid-activated nuclear receptors.
Nature 2008;454(7203):470-7.
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2008: Bensinger Steven J; Bradley Michelle N; Joseph Sean B; Zelcer Noam; Janssen Edith M; Hausner Mary Ann; Shih Roger; Parks John S; Edwards Peter A; Jamieson Beth D; Tontonoz Peter
LXR signaling couples sterol metabolism to proliferation in the acquired immune response.
Cell 2008;134(1):97-111.
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2008: Jiang Qingguang; Lee C Y Daniel; Mandrekar Shweta; Wilkinson Brandy; Cramer Paige; Zelcer Noam; Mann Karen; Lamb Bruce; Willson Timothy M; Collins Jon L; Richardson Jill C; Smith Jonathan D; Comery Thomas A; Riddell David; Holtzman David M; Tontonoz Peter; Landreth Gary E
ApoE promotes the proteolytic degradation of Abeta.
Neuron 2008;58(5):681-93.
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2008: Gallardo-Soler Alejandro; Gómez-Nieto Carlos; Campo María Luisa; Marathe Chaitra; Tontonoz Peter; Castrillo Antonio; Corraliza Inés
Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity.
Molecular endocrinology (Baltimore, Md.) 2008;22(6):1394-402.
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2008: Tontonoz Peter; Spiegelman Bruce M
Fat and beyond: the diverse biology of PPARgamma.
Annual review of biochemistry 2008;77():289-312.
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2007: Chao Lily C; Zhang Zidong; Pei Liming; Saito Tsugumichi; Tontonoz Peter; Pilch Paul F
Nur77 coordinately regulates expression of genes linked to glucose metabolism in skeletal muscle.
Molecular endocrinology (Baltimore, Md.) 2007;21(9):2152-63.
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2007: Molteni Valentina; Li Xiaolin; Nabakka Juliet; Liang Fang; Wityak John; Koder Alan; Vargas Leo; Romeo Russell; Mitro Nico; Mak Puiying A; Seidel H Martin; Haslam Jennifer A; Chow Donald; Tuntland Tove; Spalding Tracy A; Brock Ansgar; Bradley Michelle; Castrillo Antonio; Tontonoz Peter; Saez Enrique
N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta.
Journal of medicinal chemistry 2007;50(17):4255-9.
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2007: Bradley Michelle N; Hong Cynthia; Chen Mingyi; Joseph Sean B; Wilpitz Damien C; Wang Xuping; Lusis Aldons J; Collins Allan; Hseuh Willa A; Collins Jon L; Tangirala Rajendra K; Tontonoz Peter
Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE.
The Journal of clinical investigation 2007;117(8):2337-46.
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2007: Zelcer Noam; Khanlou Negar; Clare Ryan; Jiang Qingguang; Reed-Geaghan Erin G; Landreth Gary E; Vinters Harry V; Tontonoz Peter
Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(25):10601-6.
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2007: Waki Hironori; Park Kye Won; Mitro Nico; Pei Liming; Damoiseaux Robert; Wilpitz Damien C; Reue Karen; Saez Enrique; Tontonoz Peter
The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression.
Cell metabolism 2007;5(5):357-70.
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2007: Waki Hironori; Tontonoz Peter
STAMPing out Inflammation.
Cell 2007;129(3):451-2.
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2007: Cao Fei; Castrillo Antonio; Tontonoz Peter; Re Fabio; Byrne Gerald I
Chlamydia pneumoniae--induced macrophage foam cell formation is mediated by Toll-like receptor 2.
Infection and immunity 2007;75(2):753-9.
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2007: Waki Hironori; Tontonoz Peter
Endocrine functions of adipose tissue.
Annual review of pathology 2007;2():31-56.
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2006: Blaschke Florian; Takata Yasunori; Caglayan Evren; Collins Alan; Tontonoz Peter; Hsueh Willa A; Tangirala Rajendra K
A nuclear receptor corepressor-dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor.
Circulation research 2006;99(12):e88-99.
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2006: Chow Edward K; Castrillo Antonio; Shahangian Arash; Pei Liming; O'Connell Ryan M; Modlin Robert L; Tontonoz Peter; Cheng Genhong
A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections.
The Journal of experimental medicine 2006;203(12):2589-602.
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2006: Marathe Chaitra; Bradley Michelle N; Hong Cynthia; Lopez Felix; Ruiz de Galarreta Carlos M; Tontonoz Peter; Castrillo Antonio
The arginase II gene is an anti-inflammatory target of liver X receptor in macrophages.
The Journal of biological chemistry 2006;281(43):32197-206.
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2006: Baldán Angel; Pei Liming; Lee Richard; Tarr Paul; Tangirala Rajendra K; Weinstein Michael M; Frank Joy; Li Andrew C; Tontonoz Peter; Edwards Peter A
Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(10):2301-7.
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2006: Pei Liming; Waki Hironori; Vaitheesvaran Bhavapriya; Wilpitz Damien C; Kurland Irwin J; Tontonoz Peter
NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism.
Nature medicine 2006;12(9):1048-55.
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2006: Chen Mingyi; Bradley Michelle N; Beaven Simon W; Tontonoz Peter
Phosphorylation of the liver X receptors.
FEBS letters 2006;580(20):4835-41.
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2006: Hummasti Sarah; Tontonoz Peter
The peroxisome proliferator-activated receptor N-terminal domain controls isotype-selective gene expression and adipogenesis.
Molecular endocrinology (Baltimore, Md.) 2006;20(6):1261-75.
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2006: Pei Liming; Castrillo Antonio; Tontonoz Peter
Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77.
Molecular endocrinology (Baltimore, Md.) 2006;20(4):786-94.
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2006: Zelcer Noam; Tontonoz Peter
Liver X receptors as integrators of metabolic and inflammatory signaling.
The Journal of clinical investigation 2006;116(3):607-14.
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2006: Beaven Simon W; Tontonoz Peter
Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia.
Annual review of medicine 2006;57():313-29.
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2005: Chen Mingyi; Beaven Simon; Tontonoz Peter
Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha.
Journal of lipid research 2005;46(12):2570-9.
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2005: Zelcer Noam; Tontonoz Peter
SUMOylation and PPARgamma: wrestling with inflammatory signaling.
Cell metabolism 2005;2(5):273-5.
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2005: Pei Liming; Castrillo Antonio; Chen Mingyi; Hoffmann Alexander; Tontonoz Peter
Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli.
The Journal of biological chemistry 2005;280(32):29256-62.
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2005: Arai Satoko; Shelton John M; Chen Mingyi; Bradley Michelle N; Castrillo Antonio; Bookout Angie L; Mak Puiying A; Edwards Peter A; Mangelsdorf David J; Tontonoz Peter; Miyazaki Toru
A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development.
Cell metabolism 2005;1(3):201-13.
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2005: Lin Jiandie; Yang Ruojing; Tarr Paul T; Wu Pei-Hsuan; Handschin Christoph; Li Siming; Yang Wenli; Pei Liming; Uldry Marc; Tontonoz Peter; Newgard Christopher B; Spiegelman Bruce M
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.
Cell 2005;120(2):261-73.
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2005: Bradley Michelle N; Tontonoz Peter
Lesion macrophages are a key target for the antiatherogenic effects of LXR agonists.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(1):10-1.
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2005: Sheth Sonal S; Castellani Lawrence W; Chari Soumya; Wagg Cory; Thipphavong Christopher K; Bodnar Jackie S; Tontonoz Peter; Attie Alan D; Lopaschuk Gary D; Lusis Aldons J
Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition.
Journal of lipid research 2005;46(1):123-34.
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2004: Castrillo Antonio; Tontonoz Peter
PPARs in atherosclerosis: the clot thickens.
The Journal of clinical investigation 2004;114(11):1538-40.
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2004: Joseph Sean B; Bradley Michelle N; Castrillo Antonio; Bruhn Kevin W; Mak Puiying A; Pei Liming; Hogenesch John; O'connell Ryan M; Cheng Genhong; Saez Enrique; Miller Jeffery F; Tontonoz Peter
LXR-dependent gene expression is important for macrophage survival and the innate immune response.
Cell 2004;119(2):299-309.
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2004: Hummasti Sarah; Laffitte Bryan A; Watson Michael A; Galardi Cristin; Chao Lily C; Ramamurthy Lakshman; Moore John T; Tontonoz Peter
Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target.
Journal of lipid research 2004;45(4):616-25.
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2004: Pei Liming; Tontonoz Peter
Fat's loss is bone's gain.
The Journal of clinical investigation 2004;113(6):805-6.
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2004: Walczak Robert; Joseph Sean B; Laffitte Bryan A; Castrillo Antonio; Pei Liming; Tontonoz Peter
Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors.
The Journal of biological chemistry 2004;279(11):9905-11.
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2004: Castrillo Antonio; Tontonoz Peter
Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammation.
Annual review of cell and developmental biology 2004;20():455-80.
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2003: Walczak Robert; Tontonoz Peter
Setting fat on fire.
Nature medicine 2003;9(11):1348-9.
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2003: Castrillo Antonio; Joseph Sean B; Vaidya Sagar A; Haberland Margaret; Fogelman Alan M; Cheng Genhong; Tontonoz Peter
Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism.
Molecular cell 2003;12(4):805-16.
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2003: Tontonoz Peter; Mangelsdorf David J
Liver X receptor signaling pathways in cardiovascular disease.
Molecular endocrinology (Baltimore, Md.) 2003;17(6):985-93.
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2003: Laffitte Bryan A; Chao Lily C; Li Jing; Walczak Robert; Hummasti Sarah; Joseph Sean B; Castrillo Antonio; Wilpitz Damien C; Mangelsdorf David J; Collins Jon L; Saez Enrique; Tontonoz Peter
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5419-24.
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2003: Joseph Sean B; Tontonoz Peter
LXRs: new therapeutic targets in atherosclerosis?
Current opinion in pharmacology 2003;3(2):192-7.
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2003: Laffitte Bryan A; Joseph Sean B; Chen Mingyi; Castrillo Antonio; Repa Joyce; Wilpitz Damien; Mangelsdorf David; Tontonoz Peter
The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions.
Molecular and cellular biology 2003;23(6):2182-91.
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2003: Castrillo Antonio; Joseph Sean B; Marathe Chaitra; Mangelsdorf David J; Tontonoz Peter
Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages.
The Journal of biological chemistry 2003;278(12):10443-9.
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2003: Joseph Sean B; Castrillo Antonio; Laffitte Bryan A; Mangelsdorf David J; Tontonoz Peter
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors.
Nature medicine 2003;9(2):213-9.
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2002: Xu Jun; Xiao Gary; Trujillo Chuck; Chang Vicky; Blanco Lilia; Joseph Sean B; Bassilian Sara; Saad Mohammed F; Tontonoz Peter; Lee W N Paul; Kurland Irwin J
Peroxisome proliferator-activated receptor alpha (PPARalpha) influences substrate utilization for hepatic glucose production.
The Journal of biological chemistry 2002;277(52):50237-44.
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2002: Tangirala Rajendra K; Bischoff Eric D; Joseph Sean B; Wagner Brandee L; Walczak Robert; Laffitte Bryan A; Daige Chris L; Thomas Diane; Heyman Richard A; Mangelsdorf David J; Wang Xuping; Lusis Aldons J; Tontonoz Peter; Schulman Ira G
Identification of macrophage liver X receptors as inhibitors of atherosclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11896-901.
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2002: Mak Puiying A; Laffitte Bryan A; Desrumaux Catherine; Joseph Sean B; Curtiss Linda K; Mangelsdorf David J; Tontonoz Peter; Edwards Peter A
Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.
The Journal of biological chemistry 2002;277(35):31900-8.
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2002: Joseph Sean B; McKilligin Elaine; Pei Liming; Watson Michael A; Collins Alan R; Laffitte Bryan A; Chen Mingyi; Noh Grace; Goodman Joanne; Hagger Graham N; Tran Jonathan; Tippin Tim K; Wang Xuping; Lusis Aldons J; Hsueh Willa A; Law Ronald E; Collins Jon L; Willson Timothy M; Tontonoz Peter
Synthetic LXR ligand inhibits the development of atherosclerosis in mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7604-9.
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2002: Laffitte Bryan A; Tontonoz Peter
Orphan nuclear receptors find a home in the arterial wall.
Current atherosclerosis reports 2002;4(3):213-21.
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2002: Joseph Sean B; Laffitte Bryan A; Patel Parthive H; Watson Michael A; Matsukuma Karen E; Walczak Robert; Collins Jon L; Osborne Timothy F; Tontonoz Peter
Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors.
The Journal of biological chemistry 2002;277(13):11019-25.
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2002: Walczak Robert; Tontonoz Peter
PPARadigms and PPARadoxes: expanding roles for PPARgamma in the control of lipid metabolism.
Journal of lipid research 2002;43(2):177-86.
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2002: Kast Heidi R; Goodwin Bryan; Tarr Paul T; Jones Stacey A; Anisfeld Andrew M; Stoltz Catherine M; Tontonoz Peter; Kliewer Steve; Willson Timothy M; Edwards Peter A
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.
The Journal of biological chemistry 2002;277(4):2908-15.
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2001: Laffitte B A; Joseph S B; Walczak R; Pei L; Wilpitz D C; Collins J L; Tontonoz P
Autoregulation of the human liver X receptor alpha promoter.
Molecular and cellular biology 2001;21(22):7558-68.
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2001: Singh Ahuja H; Liu S; Crombie D L; Boehm M; Leibowitz M D; Heyman R A; Depre C; Nagy L; Tontonoz P; Davies P J
Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents.
Molecular pharmacology 2001;59(4):765-73.
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2001: Chawla A; Boisvert W A; Lee C H; Laffitte B A; Barak Y; Joseph S B; Liao D; Nagy L; Edwards P A; Curtiss L K; Evans R M; Tontonoz P
A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis.
Molecular cell 2001;7(1):161-71.
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2001: Laffitte B A; Repa J J; Joseph S B; Wilpitz D C; Kast H R; Mangelsdorf D J; Tontonoz P
LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(2):507-12.
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2001: Chawla A; Barak Y; Nagy L; Liao D; Tontonoz P; Evans R M
PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation.
Nature medicine 2001;7(1):48-52.
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2000: Venkateswaran A; Laffitte B A; Joseph S B; Mak P A; Wilpitz D C; Edwards P A; Tontonoz P
Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12097-102.
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2000: Lee H; Shi W; Tontonoz P; Wang S; Subbanagounder G; Hedrick C C; Hama S; Borromeo C; Evans R M; Berliner J A; Nagy L
Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells.
Circulation research 2000;87(6):516-21.
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1998: Saez E; Tontonoz P; Nelson M C; Alvarez J G; Ming U T; Baird S M; Thomazy V A; Evans R M
Activators of the nuclear receptor PPARgamma enhance colon polyp formation.
Nature medicine 1998;4(9):1058-61.
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1998: Tontonoz P; Nagy L; Alvarez J G; Thomazy V A; Evans R M
PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL.
Cell 1998;93(2):241-52.
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1998: Nagy L; Tontonoz P; Alvarez J G; Chen H; Evans R M
Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma.
Cell 1998;93(2):229-40.
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