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Knut Martin Torgersen

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Chemicals & Drugs

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Torkel Vang; Marte K Viken; Johannes Landskron; Tomas Mustelin; Nikolaus Oberprieler; Robert C Rickert; Kjetil Tasken; Lutz Tautz; Knut Martin Torgersen; Benedicte A Lie
The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses.
Endalkachew Ashenafi Alemu; Aasa Birna Birgisdottir; Ashish Jain; Vladimir Kirkin; Trond Lamark; Kenneth Bowitz Larsen; Hallvard Olsvik; Knut Martin Torgersen; Aud Øvervatn; Terje Johansen
ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs.
Maria Elisabeth Kalland; Nikolaus G Oberprieler; Kjetil Taskén; Torkel Vang; Knut Martin Torgersen
T cell-signaling network analysis reveals distinct differences between CD28 and CD2 costimulation responses in various subsets and in the MAPK pathway between resting and activated regulatory T cells.

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All Publications

2013: Torkel Vang; Marte K Viken; Johannes Landskron; Tomas Mustelin; Nikolaus Oberprieler; Robert C Rickert; Kjetil Tasken; Lutz Tautz; Knut Martin Torgersen; Benedicte A Lie
The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses.
Human immunology 2013;74(5):574-85.
2012: Endalkachew Ashenafi Alemu; Aasa Birna Birgisdottir; Ashish Jain; Vladimir Kirkin; Trond Lamark; Kenneth Bowitz Larsen; Hallvard Olsvik; Knut Martin Torgersen; Aud Øvervatn; Terje Johansen
ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs.
The Journal of biological chemistry 2012;287(47):39275-90.
2011: Maria Elisabeth Kalland; Nikolaus G Oberprieler; Kjetil Taskén; Torkel Vang; Knut Martin Torgersen
T cell-signaling network analysis reveals distinct differences between CD28 and CD2 costimulation responses in various subsets and in the MAPK pathway between resting and activated regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(10):5233-45.
2011: Therese Solstad; Kjetil Taskén; Bernd Thiede; Einar Martin Aandahl; Simer Jit Bains; Johannes Landskron; Knut Martin Torgersen
CD147 (Basigin/Emmprin) identifies FoxP3+CD45RO+CTLA4+-activated human regulatory T cells.
Blood 2011;118(19):5141-51.
2010: Nikolaus G Oberprieler; Simone Lemeer; Maria E Kalland; Knut Martin Torgersen; Albert J R Heck; Kjetil Taskén
High-resolution mapping of prostaglandin E2-dependent signaling networks identifies a constitutively active PKA signaling node in CD8+CD45RO+ T cells.
Blood 2010;116(13):2253-65.
2010: Therese Solstad; Elisa Bjørgo; Christian J Koehler; Margarita Strozynski; Knut Martin Torgersen; Kjetil Taskén; Bernd Thiede
Quantitative proteome analysis of detergent-resistant membranes identifies the differential regulation of protein kinase C isoforms in apoptotic T cells.
Proteomics 2010;10(15):2758-68.
2010: Dalya R Soond; Elisa Bjørgo; Kristine Moltu; Verity Q Dale; Daniel Patton; Knut Martin Torgersen; Fiona Galleway; Breda Twomey; Jonathan Clark; J S Hill Gaston; Kjetil Taskén; Peter Bunyard; Klaus Okkenhaug
PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans.
Blood 2010;115(11):2203-13.
2009: Elisabeth Jarnaess; Anne Jorunn Stokka; Anne-Katrine Kvissel; Bjørn S Skålhegg; Knut Martin Torgersen; John D Scott; Cathrine R Carlson; Kjetil Taskén
Splicing factor arginine/serine-rich 17A (SFRS17A) is an A-kinase anchoring protein that targets protein kinase A to splicing factor compartments.
The Journal of biological chemistry 2009;284(50):35154-64.
2009: Espen Aberg; Knut Martin Torgersen; Bjarne Johansen; Stephen M Keyse; Maria Perander; Ole Morten Seternes
Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif.
The Journal of biological chemistry 2009;284(29):19392-401.
2009: eirik torheim; Lishomwa C Ndhlovu; Frank O Pettersen; Trine-Lise Larsen; Aashish R Jha; Knut Martin Torgersen; Dag Kvale; Douglas F Nixon; Kjetil Taskén; Einar M Aandahl
Interleukin-10-secreting T cells define a suppressive subset within the HIV-1-specific T-cell population.
European journal of immunology 2009;39(5):1280-7.
2008: Jacob Ngai; Trond Methi; Kjetil Wessel Andressen; Finn Olav Levy; Knut Martin Torgersen; Torkel Vang; Nina Wettschureck; Kjetil Taskén
The heterotrimeric G-protein alpha-subunit Galphaq regulates TCR-mediated immune responses through an Lck-dependent pathway.
European journal of immunology 2008;38(11):3208-18.
2008: Einar M Aandahl; Knut Martin Torgersen; Kjetil Taskén
CD8+ regulatory T cells-A distinct T-cell lineage or a transient T-cell phenotype?
Human immunology 2008;69(11):696-9.
2008: Milada Mahic; M E Kalland; Einar M Aandahl; Knut Martin Torgersen; Kjetil Taskén
Human naturally occurring and adaptive regulatory T cells secrete high levels of leukaemia inhibitory factor upon activation.
Scandinavian journal of immunology 2008;68(4):391-6.
2008: Trond Methi; Tone Berge; Knut Martin Torgersen; Kjetil Taskén
Reduced Cbl phosphorylation and degradation of the zeta-chain of the T-cell receptor/CD3 complex in T cells with low Lck levels.
European journal of immunology 2008;38(9):2557-63.
2008: Milada Mahic; Sheraz Yaqub; Tone Bryn; Karen Henjum; Dag M Eide; Knut Martin Torgersen; Einar M Aandahl; Kjetil Taskén
Differentiation of naive CD4+ T cells into CD4+CD25+FOXP3+ regulatory T cells by continuous antigen stimulation.
Journal of leukocyte biology 2008;83(5):1111-7.
2008: Milada Mahic; Karen Henjum; Sheraz Yaqub; Bjørn Atle Bjørnbeth; Knut Martin Torgersen; Kjetil Taskén; Einar M Aandahl
Generation of highly suppressive adaptive CD8(+)CD25(+)FOXP3(+) regulatory T cells by continuous antigen stimulation.
European journal of immunology 2008;38(3):640-6.
2008: Silje Anette Solheim; Knut Martin Torgersen; Kjetil Taskén; Tone Berge
Regulation of FynT function by dual domain docking on PAG/Cbp.
The Journal of biological chemistry 2008;283(5):2773-83.
2007: Trond Methi; Jacob Ngai; Torkel Vang; Knut Martin Torgersen; Kjetil Taskén
Hypophosphorylated TCR/CD3zeta signals through a Grb2-SOS1-Ras pathway in Lck knockdown cells.
European journal of immunology 2007;37(9):2539-48.
2005: Yenan T Bryceson; Knut Martin Torgersen; Marit Inngjerdingen; Siri F Berg; Sigurd E Hoelsbrekken; Sigbjørn Fossum; Erik Dissen
The rat orthologue to the inhibitory receptor gp49B is expressed by neutrophils and monocytes, but not by NK cells or mast cells.
European journal of immunology 2005;35(4):1230-9.
2003: Kristine B Gutzkow; Hege U Låhne; Soheil Naderi; Knut Martin Torgersen; Bjørn S Skålhegg; Mamoru Koketsu; Yoshimasa Uehara; Heidi Kiil Blomhoff
Cyclic AMP inhibits translation of cyclin D3 in T lymphocytes at the level of elongation by inducing eEF2-phosphorylation.
Cellular signalling 2003;15(9):871-81.
2003: Ingunn H Westgaard; Erik Dissen; Knut Martin Torgersen; Sasha Lazetic; Lewis L Lanier; Joseph H Phillips; Sigbjørn Fossum
The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity.
The Journal of experimental medicine 2003;197(11):1551-61.
2003: Sheraz Yaqub; Hilde Abrahamsen; Bastian Zimmermann; Natalya Kholod; Knut Martin Torgersen; Tomas Mustelin; Friedrich W Herberg; Kjetil Taskén; Torkel Vang
Activation of C-terminal Src kinase (Csk) by phosphorylation at serine-364 depends on the Csk-Src homology 3 domain.
The Biochemical journal 2003;372(Pt 1):271-8.
2002: Marit Inngjerdingen; Knut Martin Torgersen; Azzam A Maghazachi
Lck is required for stromal cell-derived factor 1 alpha (CXCL12)-induced lymphoid cell chemotaxis.
Blood 2002;99(12):4318-25.
2002: Knut Martin Torgersen; Torkel Vang; Hilde Abrahamsen; Sheraz Yaqub; Kjetil Taskén
Molecular mechanisms for protein kinase A-mediated modulation of immune function.
Cellular signalling 2002;14(1):1-9.
2001: Knut Martin Torgersen; Torkel Vang; Hilde Abrahamsen; Sheraz Yaqub; Václav Horejsí; B Schraven; Bent Rolstad; Tomas Mustelin; Kjetil Taskén
Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts.
The Journal of biological chemistry 2001;276(31):29313-8.
2001: Knut Martin Torgersen; John T Vaage; Bent Rolstad; Kjetil Taskén
A soluble LAT deletion mutant inhibits T-cell activation: reduced recruitment of signalling molecules to glycolipid-enriched microdomains.
Cellular signalling 2001;13(3):213-20.
2001: Torkel Vang; Knut Martin Torgersen; V Sundvold; M Saxena; Finn Olav Levy; Bjørn S Skålhegg; V Hansson; Tomas Mustelin; Kjetil Taskén
Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor.
The Journal of experimental medicine 2001;193(4):497-507.
2000: V Sundvold; Knut Martin Torgersen; NH Post; Francesc Marti; Philip D King; John-Arne Rottingen; Anne Spurkland; Tor Lea
T cell-specific adapter protein inhibits T cell activation by modulating Lck activity.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):2927-31.
2000: Kjetil Taskén; V Hansson; Pål Aukrust; Stig S Frøland; Bjørn S Skålhegg; F Müller; D Tobin; Torkel Vang; Knut Martin Torgersen; Einar M Aandahl
PKAI as a potential target for therapeutic intervention.
Drug news & perspectives 2000;13(1):12-8.
1998: J R Weber; Sigurd Orstavik; Knut Martin Torgersen; N C Danbolt; Siri F Berg; James C Ryan; Kjetil Taskén; John B Imboden; John T Vaage
Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells.
The Journal of experimental medicine 1998;187(7):1157-61.
1997: Knut Martin Torgersen; John T Vaage; Finn Olav Levy; V Hansson; Bent Rolstad; Kjetil Taskén
Selective activation of cAMP-dependent protein kinase type I inhibits rat natural killer cell cytotoxicity.
The Journal of biological chemistry 1997;272(9):5495-500.
1997: Knut Martin Torgersen; M Salcedo; John T Vaage; Christian Naper; Bent Rolstad; H G Ljunggren; P Höglund
Major histocompatibility complex class I-independent killing of xenogeneic targets by rat allospecific natural killer cells.
Transplantation 1997;63(1):119-23.
1997: Kjetil Taskén; Bjørn S Skålhegg; K A Taskén; Rigmor Solberg; Helle K Knutsen; Finn Olav Levy; M Sandberg; Sigurd Orstavik; T Larsen; A K Johansen; Torkel Vang; H P Schrader; Nils Reinton; Knut Martin Torgersen; V Hansson; Tore Jahnsen
Structure, function, and regulation of human cAMP-dependent protein kinases.
Advances in second messenger and phosphoprotein research 1997;31():191-204.
1996: Azzam A Maghazachi; A Al-Aoukaty; Christian Naper; Knut Martin Torgersen; Bent Rolstad
Preferential involvement of Go and Gz proteins in mediating rat natural killer cell lysis of allogeneic and tumor target cells.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(12):5308-14.