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Francesca Bosetti

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Chemicals & Drugs

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Sang-Ho Choi; Yasuji Matsuoka; Mark P Mattson; Takako Niikura; Raymond Scott Turner; S Sakura Minami; Saba Aid; Luca Caracciolo; Francesca Bosetti
Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease.
Isabella Russo; David Tweedie; Sergio Barlati; Luca Caracciolo; Sang-Ho Choi; Nigel H Greig; Francesca Bosetti
3,6'-Dithiothalidomide, a new TNF-α synthesis inhibitor, attenuates the effect of Aβ1-42 intracerebroventricular injection on hippocampal neurogenesis and memory deficit.
Sara Palumbo; Laura Parente; Christopher D Toscano; Roberto Weigert; Francesca Bosetti
The cyclooxygenase-2 pathway via the PGE₂ EP2 receptor contributes to oligodendrocytes apoptosis in cuprizone-induced demyelination.

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All Publications

2013: Sang-Ho Choi; Yasuji Matsuoka; Mark P Mattson; Takako Niikura; Raymond Scott Turner; S Sakura Minami; Saba Aid; Luca Caracciolo; Francesca Bosetti
Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease.
Journal of neurochemistry 2013;124(1):59-68.
2012: Isabella Russo; David Tweedie; Sergio Barlati; Luca Caracciolo; Sang-Ho Choi; Nigel H Greig; Francesca Bosetti
3,6'-Dithiothalidomide, a new TNF-α synthesis inhibitor, attenuates the effect of Aβ1-42 intracerebroventricular injection on hippocampal neurogenesis and memory deficit.
Journal of neurochemistry 2012;122(6):1181-92.
2012: Sara Palumbo; Laura Parente; Christopher D Toscano; Roberto Weigert; Francesca Bosetti
The cyclooxygenase-2 pathway via the PGE₂ EP2 receptor contributes to oligodendrocytes apoptosis in cuprizone-induced demyelination.
Journal of neurochemistry 2012;121(3):418-27.
2012: Jongho Lee; Sara Palumbo; Karin Shmueli; Afonso C Silva; Peter van Gelderen; Bing Yao; Francesca Bosetti; Masaki Fukunaga; Byeong-Teck Kang; Jeff H Duyn
The contribution of myelin to magnetic susceptibility-weighted contrasts in high-field MRI of the brain.
NeuroImage 2012;59(4):3967-75.
2012: David Tweedie; Henriette van Praag; Isabella Russo; Sergio Barlati; Francesca Bosetti; Luca Caracciolo; Ryan A Ferguson; Kelly Fishman; Kathryn A Frankola; Nigel H Greig; Harold W Holloway; Debomoy K Lahiri; Yazhou Li; Weiming Luo; Balmiki Ray; Susanna Rosi
Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease.
Journal of neuroinflammation 2012;9():106.
2011: K Yoshikawa; S Palumbo; C D Toscano; Francesca Bosetti
Inhibition of 5-lipoxygenase activity in mice during cuprizone-induced demyelination attenuates neuroinflammation, motor dysfunction and axonal damage.
Prostaglandins, leukotrienes, and essential fatty acids 2011;85(1):43-52.
2011: Isabella Russo; Sergio Barlati; Francesca Bosetti
Effects of neuroinflammation on the regenerative capacity of brain stem cells.
Journal of neurochemistry 2011;116(6):947-56.
2011: Luca Caracciolo; Alessandro Barbon; Sara Palumbo; Cristina Mora; Christopher D Toscano; Francesca Bosetti; Sergio Barlati
Altered mRNA editing and expression of ionotropic glutamate receptors after kainic acid exposure in cyclooxygenase-2 deficient mice.
PloS one 2011;6(5):e19398.
2011: Saba Aïd; Francesca Bosetti
Targeting cyclooxygenases-1 and -2 in neuroinflammation: Therapeutic implications.
Biochimie 2011;93(1):46-51.
2010: S-H Choi; S Aid; U Choi; Francesca Bosetti
Cyclooxygenases-1 and -2 differentially modulate leukocyte recruitment into the inflamed brain.
The pharmacogenomics journal 2010;10(5):448-57.
2010: Saba Aid; Nishant Parikh; Sara Palumbo; Francesca Bosetti
Neuronal overexpression of cyclooxygenase-2 does not alter the neuroinflammatory response during brain innate immune activation.
Neuroscience letters 2010;478(3):113-8.
2010: Saba Aid; Afonso C Silva; Eduardo Candelario-Jalil; Sang-Ho Choi; Gary A Rosenberg; Francesca Bosetti
Cyclooxygenase-1 and -2 differentially modulate lipopolysaccharide-induced blood-brain barrier disruption through matrix metalloproteinase activity.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010;30(2):370-80.
2010: S Sakura Minami; Elkhansa Sidahmed; Saba Aid; Mika Shimoji; Takako Niikura; Italo Mocchetti; G William Rebeck; Jay S Prendergast; Chris Dealwis; Ronald Wetzel; Francesca Bosetti; Yasuji Matsuoka; Hyang-Sook Hoe; Raymond Scott Turner
Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease.
Journal of neuroinflammation 2010;7():57.
2009: Sang-Ho Choi; Saba Aid; Francesca Bosetti
The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: implications for translational research.
Trends in pharmacological sciences 2009;30(4):174-81.
2009: Sang-Ho Choi; Francesca Bosetti
Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid.
Aging 2009;1(2):234-44.
2008: Sang-Ho Choi; Robert Langenbach; Francesca Bosetti
Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(5):1491-501.
2008: Christopher D Toscano; Yumi Ueda; York A Tomita; Stefano Vicini; Francesca Bosetti
Altered GABAergic neurotransmission is associated with increased kainate-induced seizure in prostaglandin-endoperoxide synthase-2 deficient mice.
Brain research bulletin 2008;75(5):598-609.
2008: Francesca Bosetti; Christopher D Toscano
Is it time to standardize ethics guiding the peer review process?
Lipids 2008;43(2):107-8.
2008: Saba Aid; Robert Langenbach; Francesca Bosetti
Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2.
Journal of neuroinflammation 2008;5():17.
2007: M Elizabeth Sublette; Francesca Bosetti; James C DeMar; Kaizong Ma; Jane M Bell; Stephanie Fagin Jones; Mark Russ; Stanley I Rapoport
Plasma free polyunsaturated fatty acid levels are associated with symptom severity in acute mania.
Bipolar disorders 2007;9(7):759-65.
2007: Francesca Bosetti
Arachidonic acid metabolism in brain physiology and pathology: lessons from genetically altered mouse models.
Journal of neurochemistry 2007;102(3):577-86.
2007: Saba Aïd; Francesca Bosetti
Gene expression of cyclooxygenase-1 and Ca(2+)-independent phospholipase A(2) is altered in rat hippocampus during normal aging.
Brain research bulletin 2007;73(1-3):108-13.
2007: Christopher D Toscano; Vinaykumar V Prabhu; Robert Langenbach; Kevin G Becker; Francesca Bosetti
Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain.
Genome biology 2007;8(1):R14.
2006: Sang-Ho Choi; Robert Langenbach; Francesca Bosetti
Cyclooxygenase-1 and -2 enzymes differentially regulate the brain upstream NF-kappa B pathway and downstream enzymes involved in prostaglandin biosynthesis.
Journal of neurochemistry 2006;98(3):801-11.
2006: Gayani R Weerasinghe; Steven L Coon; Abesh Kumar Bhattacharjee; G Jean Harry; Francesca Bosetti
Regional protein levels of cytosolic phospholipase A2 and cyclooxygenase-2 in Rhesus monkey brain as a function of age.
Brain research bulletin 2006;69(6):614-21.
2005: Jagadeesh S Rao; Stanley I Rapoport; Francesca Bosetti
Decrease in the AP-2 DNA-binding activity and in the protein expression of AP-2 alpha and AP-2 beta in frontal cortex of rats treated with lithium for 6 weeks.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(11):2006-13.
2005: Jagadeesh S Rao; Robert Langenbach; Francesca Bosetti
Down-regulation of brain nuclear factor-kappa B pathway in the cyclooxygenase-2 knockout mouse.
Brain research. Molecular brain research 2005;139(2):217-24.
2005: Sandra Ghelardoni; Richard P Bazinet; Stanley I Rapoport; Francesca Bosetti
Topiramate does not alter expression in rat brain of enzymes of arachidonic acid metabolism.
Psychopharmacology 2005;180(3):523-9.
2005: Ho-Joo Lee; Sandra Ghelardoni; Lisa Chang; Francesca Bosetti; Stanley I Rapoport; Richard P Bazinet
Topiramate does not alter the kinetics of arachidonic or docosahexaenoic acid in brain phospholipids of the unanesthetized rat.
Neurochemical research 2005;30(5):677-83.
2005: Francesca Bosetti; Jane M Bell; Pachiappan Manickam
Microarray analysis of rat brain gene expression after chronic administration of sodium valproate.
Brain research bulletin 2005;65(4):331-8.
2004: Francesca Bosetti; Robert Langenbach; Gayani R Weerasinghe
Prostaglandin E2 and microsomal prostaglandin E synthase-2 expression are decreased in the cyclooxygenase-2-deficient mouse brain despite compensatory induction of cyclooxygenase-1 and Ca2+-dependent phospholipase A2.
Journal of neurochemistry 2004;91(6):1389-97.
2004: Sandra Ghelardoni; York A Tomita; Jane M Bell; Stanley I Rapoport; Francesca Bosetti
Chronic carbamazepine selectively downregulates cytosolic phospholipase A2 expression and cyclooxygenase activity in rat brain.
Biological psychiatry 2004;56(4):248-54.
2004: Gayani R Weerasinghe; Stanley I Rapoport; Francesca Bosetti
The effect of chronic lithium on arachidonic acid release and metabolism in rat brain does not involve secretory phospholipase A2 or lipoxygenase/cytochrome P450 pathways.
Brain research bulletin 2004;63(6):485-9.
2004: Francesca Bosetti; Alessandra Baracca; Giorgio Lenaz; Giancarlo Solaini
Increased state 4 mitochondrial respiration and swelling in early post-ischemic reperfusion of rat heart.
FEBS letters 2004;563(1-3):161-4.
2004: Thad A Rosenberger; Nelly E Villacreses; Jonathan T Hovda; Francesca Bosetti; Gayani R Weerasinghe; Robert N Wine; G Jean Harry; Stanley I Rapoport
Rat brain arachidonic acid metabolism is increased by a 6-day intracerebral ventricular infusion of bacterial lipopolysaccharide.
Journal of neurochemistry 2004;88(5):1168-78.
2003: Francesca Bosetti; Gayani R Weerasinghe
The expression of brain cyclooxygenase-2 is down-regulated in the cytosolic phospholipase A2 knockout mouse.
Journal of neurochemistry 2003;87(6):1471-7.
2003: Sibile Pardue; Stanley I Rapoport; Francesca Bosetti
Co-localization of cytosolic phospholipase A2 and cyclooxygenase-2 in Rhesus monkey cerebellum.
Brain research. Molecular brain research 2003;116(1-2):106-14.
2003: Michelangelo Mancuso; Massimiliano Filosto; Francesca Bosetti; Roberto Ceravolo; Anna Rocchi; Gloria Tognoni; Maria Laura Manca; Giancarlo Solaini; Gabriele Siciliano; Luigi Murri
Decreased platelet cytochrome c oxidase activity is accompanied by increased blood lactate concentration during exercise in patients with Alzheimer disease.
Experimental neurology 2003;182(2):421-6.
2003: Francesca Bosetti; Gayani R Weerasinghe; Thad A Rosenberger; Stanley I Rapoport
Valproic acid down-regulates the conversion of arachidonic acid to eicosanoids via cyclooxygenase-1 and -2 in rat brain.
Journal of neurochemistry 2003;85(3):690-6.
2003: Gayani R Weerasinghe; Ruth Seemann; Stanley I Rapoport; Francesca Bosetti
Lithium chloride, administered chronically to rats, does not affect the fractional phosphorylation of brain cytosolic phospholipase A2, while reducing its net protein level.
Brain research bulletin 2003;59(4):303-6.
2002: Marika Massaro; Maria Annunziata Carluccio; Aldo Paolicchi; Francesca Bosetti; Giancarlo Solaini; Raffaele De Caterina
Mechanisms for reduction of endothelial activation by oleate: inhibition of nuclear factor-kappaB through antioxidant effects.
Prostaglandins, leukotrienes, and essential fatty acids 2002;67(2-3):175-81.
2002: Marika Massaro; Giuseppina Basta; Guido Lazzerini; Maria Annunziata Carluccio; Francesca Bosetti; Giancarlo Solaini; Francesco Visioli; Aldo Paolicchi; Raffaele De Caterina
Quenching of intracellular ROS generation as a mechanism for oleate-induced reduction of endothelial activation and early atherogenesis.
Thrombosis and haemostasis 2002;88(2):335-44.
2002: Francesca Bosetti; Ruth Seemann; Stanley I Rapoport
Chronic lithium chloride administration to rats decreases brain protein level of epsilon (epsilon) subunit of eukaryotic initiation factor-2B.
Neuroscience letters 2002;327(1):71-3.
2002: Francesca Bosetti; Francesca Brizzi; Silvia Barogi; Michelangelo Mancuso; Gabriele Siciliano; Elisabetta A Tendi; Luigi Murri; Stanley I Rapoport; Giancarlo Solaini
Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease.
Neurobiology of aging 2002;23(3):371-6.
2002: Elisabetta A Tendi; Francesca Bosetti; S Fenella Dasgupta; Anna Maria Giuffrida Stella; Katy Drieu; Stanley I Rapoport
Ginkgo biloba extracts EGb 761 and bilobalide increase NADH dehydrogenase mRNA level and mitochondrial respiratory control ratio in PC12 cells.
Neurochemical research 2002;27(4):319-23.
2002: Francesca Bosetti; Ruth Seemann; Jane M Bell; Robert Zahorchak; Elliott Friedman; Stanley I Rapoport; Pachiappan Manickam
Analysis of gene expression with cDNA microarrays in rat brain after 7 and 42 days of oral lithium administration.
Brain research bulletin 2002;57(2):205-9.
2002: Francesca Bosetti; JJ Rintala; Ruth Seemann; Thad A Rosenberger; Miguel A Contreras; Stanley I Rapoport; Michael C J Chang
Chronic lithium downregulates cyclooxygenase-2 activity and prostaglandin E(2) concentration in rat brain.
Molecular psychiatry 2002;7(8):845-50.
2001: Francesca Bosetti; Giancarlo Solaini; Elisabetta A Tendi; EG Chikhale; Krish Chandrasekaran; Stanley I Rapoport
Mitochondrial cytochrome c oxidase subunit III is selectively down-regulated by aluminum exposure in PC12S cells.
Neuroreport 2001;12(4):721-4.
2000: Francesca Bosetti; G Yu; Riccardo Zucchi; Simonetta Ronca-Testoni; Giancarlo Solaini
Myocardial ischemic preconditioning and mitochondrial F1F0-ATPase activity.
Molecular and cellular biochemistry 2000;215(1-2):31-7.
1999: Raffaele De Caterina; M Spiecker; Giancarlo Solaini; Giuseppina Basta; Francesca Bosetti; P Libby; J Liao
The inhibition of endothelial activation by unsaturated fatty acids.
Lipids 1999;34 Suppl():S191-4.