FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Giampaolo Tortora

Research Profile

Chemicals & Drugs

Anatomy

Tumor Cells, Cultured

Physiology

Living Beings

Disorders

Co-author Network

Publications

TOP 3
Vincenzo Damiano; Sabino De Placido; Luigi Formisano; Teresa Gelardi; R Marciano; L Nappi; R Rosa; Sudhir Agrawal; Roberto Bianco; I Cozzolino; G Troncone; B M Veneziani; Giampaolo Tortora
Toll-like receptor 9 agonist IMO cooperates with everolimus in renal cell carcinoma by interfering with tumour growth and angiogenesis.
Francesca Monteleone; Lucia Nappi; Maria Fiammetta Romano; Roberta Rosa; Andrea Scaloni; Mariangela Succoio; Giampaolo Tortora; Monica Vitale; Roberto Bianco; Chiara D'Ambrosio; Luigi Formisano; Nicola Zambrano
Increased anaerobic metabolism is a distinctive signature in a colorectal cancer cellular model of resistance to antiepidermal growth factor receptor antibody.
Alessandra Felici; Emilio Bria; Francesco Cognetti; Giampaolo Tortora; Michele Milella
Sequential therapy in metastatic clear cell renal carcinoma: TKI-TKI vs TKI-mTOR.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Giampaolo Tortora (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Vincenzo Damiano; Sabino De Placido; Luigi Formisano; Teresa Gelardi; R Marciano; L Nappi; R Rosa; Sudhir Agrawal; Roberto Bianco; I Cozzolino; G Troncone; B M Veneziani; Giampaolo Tortora
Toll-like receptor 9 agonist IMO cooperates with everolimus in renal cell carcinoma by interfering with tumour growth and angiogenesis.
British journal of cancer 2013;108(8):1616-23.
2013: Francesca Monteleone; Lucia Nappi; Maria Fiammetta Romano; Roberta Rosa; Andrea Scaloni; Mariangela Succoio; Giampaolo Tortora; Monica Vitale; Roberto Bianco; Chiara D'Ambrosio; Luigi Formisano; Nicola Zambrano
Increased anaerobic metabolism is a distinctive signature in a colorectal cancer cellular model of resistance to antiepidermal growth factor receptor antibody.
Proteomics 2013;13(5):866-77.
2012: Alessandra Felici; Emilio Bria; Francesco Cognetti; Giampaolo Tortora; Michele Milella
Sequential therapy in metastatic clear cell renal carcinoma: TKI-TKI vs TKI-mTOR.
Expert review of anticancer therapy 2012;12(12):1545-57.
2012: Fotios Loupakis; Lisa Salvatore; Marta Schirripa; Giampaolo Tortora; Vanja Vaccaro; Vittorina Zagonel; Francesco Cognetti; Chiara Cremolini; Federica Cuppone; Alfredo Falcone; Diana Giannarelli; Sara Lonardi; Emilio Bria
Clinical impact of anti-epidermal growth factor receptor monoclonal antibodies in first-line treatment of metastatic colorectal cancer: meta-analytical estimation and implications for therapeutic strategies.
Cancer 2012;118(6):1523-32.
2011: Roberta Rosa; Aldo Scarpa; Sudhir Agrawal; Alberto Bardelli; Roberto Bianco; Vincenzo Damiano; Federica Di Nicolantonio; Sonia Garofalo; Teresa Gelardi; Davide Melisi; Giampaolo Tortora
Toll-like receptor 9 agonist IMO cooperates with cetuximab in K-ras mutant colorectal and pancreatic cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(20):6531-41.
2011: Vanja Vaccaro; Maria Simona Pino; Giampaolo Tortora; Emilio Bria; Ludovica Ciuffreda; Francesco Cognetti; Federica Cuppone; alain gelibter; Davide Melisi; Michele Milella
Emerging pathways and future targets for the molecular therapy of pancreatic cancer.
Expert opinion on therapeutic targets 2011;15(10):1183-96.
2011: Donata Vitagliano; Valentina De Falco; Anna Tamburrino; Sabrina Coluzzi; Giancarlo Troncone; Gennaro Chiappetta; Fortunato Ciardiello; Giampaolo Tortora; James A Fagin; Anderson J Ryan; Francesca Carlomagno; Massimo Santoro
The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary thyroid carcinoma cells.
Endocrine-related cancer 2011;18(1):1-11.
2010: L Nappi; Luigi Formisano; V Damiano; Elide Matano; Roberto Bianco; Giampaolo Tortora
Paraneoplastic sensitive neuropathy associated with anti-hu antibodies in a neuroendocrine tumor of duodenum: a case report.
International journal of immunopathology and pharmacology 2010;23(4):1281-5.
2010: Teresa Gelardi; Vincenzo Damiano; R Rosa; Roberto Bianco; Rosanna Cozzolino; Giampaolo Tortora; Paolo Laccetti; Giuseppe D'Alessio; Claudia De Lorenzo
Two novel human anti-ErbB2 immunoagents are active on trastuzumab-resistant tumours.
British journal of cancer 2010;102(3):513-9.
2009: Vincenzo Damiano; Sonia Garofalo; Roberta Rosa; Roberto Bianco; Rosa Caputo; Teresa Gelardi; Gerardina Merola; luigi racioppi; Corrado Garbi; Ekambar R Kandimalla; Sudhir Agrawal; Giampaolo Tortora
A novel toll-like receptor 9 agonist cooperates with trastuzumab in trastuzumab-resistant breast tumors through multiple mechanisms of action.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(22):6921-30.
2008: Giampaolo Tortora; Fortunato Ciardiello; Giampietro Gasparini
Combined targeting of EGFR-dependent and VEGF-dependent pathways: rationale, preclinical studies and clinical applications.
Nature clinical practice. Oncology 2008;5(9):521-30.
2008: Roberto Bianco; Roberta Rosa; Vincenzo Damiano; gennaro daniele; Teresa Gelardi; Sonia Garofalo; Valeria Tarallo; Sandro De Falco; Davide Melisi; Roberto Benelli; Adriana Albini; Anderson Ryan; Fortunato Ciardiello; Giampaolo Tortora
Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(16):5069-80.
2008: Teresa Gelardi; Rosa Caputo; Vincenzo Damiano; gennaro daniele; Stefano Pepe; Fortunato Ciardiello; M Lahn; Roberto Bianco; Giampaolo Tortora
Enzastaurin inhibits tumours sensitive and resistant to anti-EGFR drugs.
British journal of cancer 2008;99(3):473-80.
2008: Davide Melisi; Satoshi Ishiyama; Guido M Sclabas; Jason Fleming; Qianghua Xia; Giampaolo Tortora; James L Abbruzzese; Paul J Chiao
LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis.
Molecular cancer therapeutics 2008;7(4):829-40.
2008: Roberto Bianco; S Garofalo; R Rosa; Vincenzo Damiano; Teresa Gelardi; gennaro daniele; R Marciano; Fortunato Ciardiello; Giampaolo Tortora
Inhibition of mTOR pathway by everolimus cooperates with EGFR inhibitors in human tumours sensitive and resistant to anti-EGFR drugs.
British journal of cancer 2008;98(5):923-30.
2008: Teresa Troiani; Clorinda Schettino; Erika Martinelli; Floriana Morgillo; Giampaolo Tortora; Fortunato Ciardiello
The use of xenograft models for the selection of cancer treatments with the EGFR as an example.
Critical reviews in oncology/hematology 2008;65(3):200-11.
2007: Bianca Maria Veneziani; Vittoria Criniti; Carla Cavaliere; Sara Corvigno; Agostina Nardone; Silvia Picarelli; Giampaolo Tortora; Fortunato Ciardiello; Gennaro Limite; Sabino De Placido
In vitro expansion of human breast cancer epithelial and mesenchymal stromal cells: optimization of a coculture model for personalized therapy approaches.
Molecular cancer therapeutics 2007;6(12 Pt 1):3091-100.
2007: Floriana Morgillo; Maria Anna Bareschino; Roberto Bianco; Giampaolo Tortora; Fortunato Ciardiello
Primary and acquired resistance to anti-EGFR targeted drugs in cancer therapy.
Differentiation; research in biological diversity 2007;75(9):788-99.
2007: Giuseppe Di Lorenzo; Riccardo Autorino; Sisto Perdonà; Michele De Laurentiis; Massimo D'Armiento; Giuseppe Cancello; Vincenzo Mirone; Ciro Imbimbo; Nicola Longo; Vincenzo Altieri; Giampaolo Tortora; William D Figg; Sabino De Placido
Docetaxel, vinorelbine, and zoledronic acid as first-line treatment in patients with hormone refractory prostate cancer: a phase II study.
European urology 2007;52(4):1020-7.
2007: Vincenzo Damiano; Rosa Caputo; Sonia Garofalo; Roberto Bianco; Roberta Rosa; Gerardina Merola; Teresa Gelardi; luigi racioppi; Gabriella Fontanini; Sabino De Placido; Ekambar R Kandimalla; Sudhir Agrawal; Fortunato Ciardiello; Giampaolo Tortora
TLR9 agonist acts by different mechanisms synergizing with bevacizumab in sensitive and cetuximab-resistant colon cancer xenografts.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(30):12468-73.
2007: Giampaolo Tortora; Roberto Bianco; gennaro daniele; Fortunato Ciardiello; James A McCubrey; Maria R Ricciardi; Ludovica Ciuffreda; Francesco Cognetti; Agostino Tafuri; Michele Milella
Overcoming resistance to molecularly targeted anticancer therapies: Rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2007;10(3):81-100.
2007: Erika Martinelli; Floriana Morgillo; Teresa Troiani; Giampaolo Tortora; Fortunato Ciardiello
Panitumumab: the evidence of its therapeutic potential in metastatic colorectal cancer care.
Core evidence 2007;2(2):81-8.
2007: Roberto Bianco; Vincenzo Damiano; Teresa Gelardi; gennaro daniele; Fortunato Ciardiello; Giampaolo Tortora
Rational combination of targeted therapies as a strategy to overcome the mechanisms of resistance to inhibitors of EGFR signaling.
Current pharmaceutical design 2007;13(33):3358-67.
2007: Roberto Bianco; Teresa Gelardi; Vincenzo Damiano; Fortunato Ciardiello; Giampaolo Tortora
Rational bases for the development of EGFR inhibitors for cancer treatment.
The international journal of biochemistry & cell biology 2007;39(7-8):1416-31.
2007: Giampaolo Tortora; Teresa Gelardi; Fortunato Ciardiello; Roberto Bianco
The rationale for the combination of selective EGFR inhibitors with cytotoxic drugs and radiotherapy.
The International journal of biological markers 2007;22(1 Suppl 4):S47-52.
2006: Giampaolo Tortora; gennaro daniele
[New frontiers in cancer treatment].
Recenti progressi in medicina 2006;97(12):781-6.
2006: Cataldo Bianco; Elisa Giovannetti; Fortunato Ciardiello; Valentina Mey; Sara Nannizzi; Giampaolo Tortora; Teresa Troiani; Francesco Pasqualetti; Gail Eckhardt; Mario de Liguoro; Simona Ricciardi; Mario Del Tacca; David Raben; Luca Cionini; Romano Danesi
Synergistic antitumor activity of ZD6474, an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, with gemcitabine and ionizing radiation against pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(23):7099-107.
2006: Maria Pia Morelli; Tina Cascone; Teresa Troiani; Concetta Tuccillo; Roberto Bianco; Nicola Normanno; Marco Romano; Bianca Maria Veneziani; Gabriella Fontanini; S Gail Eckhardt; Sabino De Pacido; Giampaolo Tortora; Fortunato Ciardiello
Anti-tumor activity of the combination of cetuximab, an anti-EGFR blocking monoclonal antibody and ZD6474, an inhibitor of VEGFR and EGFR tyrosine kinases.
Journal of cellular physiology 2006;208(2):344-53.
2006: Fortunato Ciardiello; Teresa Troiani; F Caputo; Michele De Laurentiis; Giampaolo Tortora; G Palmieri; Ferdinando De Vita; Maria Rosaria Diadema; Michele Orditura; G Colantuoni; Cesare Gridelli; Giuseppe Catalano; Sabino De Placido; Angelo Raffaele Bianco
Phase II study of gefitinib in combination with docetaxel as first-line therapy in metastatic breast cancer.
British journal of cancer 2006;94(11):1604-9.
2006: Fortunato Ciardiello; Teresa Troiani; Roberto Bianco; Michele Orditura; Floriana Morgillo; Erika Martinelli; Maria Pia Morelli; Tina Cascone; Giampaolo Tortora
Interaction between the epidermal growth factor receptor (EGFR) and the vascular endothelial growth factor (VEGF) pathways: a rational approach for multi-target anticancer therapy.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2006;17 Suppl 7():vii109-14.
2006: Roberto Bianco; Vincenzo Damiano; Giampaolo Tortora
Combination of biological therapies in non-small cell lung cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2006;17 Suppl 2():ii52-54.
2006: Chiara Carlomagno; Michele Orditura; Stefano Pepe; Ferdinando De Vita; Carmela Romano; Fortunato Ciardiello; Claudia Ferrara; Erika Martinelli; Roberto Bianco; Gaetano Aurilio; Diego D'Agostino; Giampaolo Tortora; Giuseppe Catalano; Sabino De Placido
Capecitabine plus weekly oxaliplatin in gastrointestinal tumors: a phase I study.
American journal of clinical oncology 2006;29(1):85-9.
2006: Roberto Bianco; Davide Melisi; Fortunato Ciardiello; Giampaolo Tortora
Key cancer cell signal transduction pathways as therapeutic targets.
European journal of cancer (Oxford, England : 1990) 2006;42(3):290-4.
2006: Vincenzo Damiano; Rosa Caputo; Roberto Bianco; Francesco P D'Armiento; Antonio Leonardi; Sabino De Placido; Angelo Raffaele Bianco; Sudhir Agrawal; Fortunato Ciardiello; Giampaolo Tortora
Novel toll-like receptor 9 agonist induces epidermal growth factor receptor (EGFR) inhibition and synergistic antitumor activity with EGFR inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(2):577-83.
2005: Davide Melisi; Rosa Caputo; Vincenzo Damiano; Roberto Bianco; Bianca Maria Veneziani; Angelo Raffaele Bianco; Sabino De Placido; Fortunato Ciardiello; Giampaolo Tortora
Zoledronic acid cooperates with a cyclooxygenase-2 inhibitor and gefitinib in inhibiting breast and prostate cancer.
Endocrine-related cancer 2005;12(4):1051-8.
2005: Vincenzo Damiano; Davide Melisi; Cataldo Bianco; David Raben; Rosa Caputo; Gabriella Fontanini; Roberto Bianco; Anderson Ryan; Angelo Raffaele Bianco; Sabino De Placido; Fortunato Ciardiello; Giampaolo Tortora
Cooperative antitumor effect of multitargeted kinase inhibitor ZD6474 and ionizing radiation in glioblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(15):5639-44.
2005: Roberto Bianco; Teresa Troiani; Giampaolo Tortora; Fortunato Ciardiello
Intrinsic and acquired resistance to EGFR inhibitors in human cancer therapy.
Endocrine-related cancer 2005;12 Suppl 1():S159-71.
2005: Michele De Laurentiis; Grazia Arpino; Erminia Massarelli; Angela Ruggiero; Chiara Carlomagno; Fortunato Ciardiello; Giampaolo Tortora; Diego D'Agostino; Francesca Caputo; Giuseppe Cancello; Emilia Montagna; Luca Malorni; Luigia Zinno; Rossella Lauria; Angelo Raffaele Bianco; Sabino De Placido
A meta-analysis on the interaction between HER-2 expression and response to endocrine treatment in advanced breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(13):4741-8.
2005: Maria Pia Morelli; Tina Cascone; Teresa Troiani; Ferdinando De Vita; Michele Orditura; Gianluca Laus; S Gail Eckhardt; Stefano Pepe; Giampaolo Tortora; Fortunato Ciardiello
Sequence-dependent antiproliferative effects of cytotoxic drugs and epidermal growth factor receptor inhibitors.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2005;16 Suppl 4():iv61-68.
2005: Roberto Bianco; gennaro daniele; Fortunato Ciardiello; Giampaolo Tortora
Monoclonal antibodies targeting the epidermal growth factor receptor.
Current drug targets 2005;6(3):275-87.
2005: Roberto Bianco; Fortunato Ciardiello; Giampaolo Tortora
Chemosensitization by antisense oligonucleotides targeting MDM2.
Current cancer drug targets 2005;5(1):51-6.
2005: Concetta Tuccillo; Marco Romano; Teresa Troiani; Erika Martinelli; Floriana Morgillo; Ferdinando De Vita; Roberto Bianco; Gabriella Fontanini; Raffaele A Bianco; Giampaolo Tortora; Fortunato Ciardiello
Antitumor activity of ZD6474, a vascular endothelial growth factor-2 and epidermal growth factor receptor small molecule tyrosine kinase inhibitor, in combination with SC-236, a cyclooxygenase-2 inhibitor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(3):1268-76.
2005: Giuseppe Di Lorenzo; Sabino De Placido; Riccardo Autorino; Michele De Laurentiis; Chiara Mignogna; Massimo D'Armiento; Giampaolo Tortora; G De Rosa; M D'Armiento; Marco De Sio; Angelo Raffaele Bianco; Francesco P D'Armiento
Expression of biomarkers modulating prostate cancer progression: implications in the treatment of the disease.
Prostate cancer and prostatic diseases 2005;8(1):54-9.
2004: Giuseppe Di Lorenzo; Carmine Pizza; Riccardo Autorino; Michele De Laurentiis; Ombretta Marano; Adele D'Alessio; Giuseppe Cancello; Vincenzo Altieri; Giampaolo Tortora; Sisto Perdonà; Angelo Raffaele Bianco; Sabino De Placido
Weekly docetaxel and vinorelbine (VIN-DOX) as first line treatment in patients with hormone refractory prostate cancer.
European urology 2004;46(6):712-6.
2004: Giampaolo Tortora; Roberto Bianco; gennaro daniele
Strategies for multiple signalling inhibition.
Journal of chemotherapy (Florence, Italy) 2004;16 Suppl 4():41-3.
2004: David Raben; Cataldo Bianco; Vincenzo Damiano; Roberto Bianco; Davide Melisi; Chiara Mignogna; Francesco P D'Armiento; Luca Cionini; Angelo Raffaele Bianco; Giampaolo Tortora; Fortunato Ciardiello; Paul A Bunn
Antitumor activity of ZD6126, a novel vascular-targeting agent, is enhanced when combined with ZD1839, an epidermal growth factor receptor tyrosine kinase inhibitor, and potentiates the effects of radiation in a human non-small cell lung cancer xenograft model.
Molecular cancer therapeutics 2004;3(8):977-83.
2004: Roberto Bianco; Rosa Caputo; Rosa Caputo; Vincenzo Damiano; Sabino De Placido; Corrado Ficorella; Sudhir Agrawal; Angelo Raffaele Bianco; Fortunato Ciardiello; Giampaolo Tortora
Combined targeting of epidermal growth factor receptor and MDM2 by gefitinib and antisense MDM2 cooperatively inhibit hormone-independent prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(14):4858-64.
2004: Fortunato Ciardiello; Ferdinando De Vita; Michele Orditura; Giampaolo Tortora
The role of EGFR inhibitors in nonsmall cell lung cancer.
Current opinion in oncology 2004;16(2):130-5.
2004: Davide Melisi; Teresa Troiani; Vincenzo Damiano; Giampaolo Tortora; Fortunato Ciardiello
Therapeutic integration of signal transduction targeting agents and conventional anti-cancer treatments.
Endocrine-related cancer 2004;11(1):51-68.
2004: Fortunato Ciardiello; Roberto Bianco; Rosa Caputo; Rosa Caputo; Vincenzo Damiano; Teresa Troiani; Davide Melisi; Ferdinando De Vita; Sabino De Placido; Angelo Raffaele Bianco; Giampaolo Tortora
Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(2):784-93.
2004: Giampaolo Tortora; Davide Melisi; Fortunato Ciardiello
Angiogenesis: a target for cancer therapy.
Current pharmaceutical design 2004;10(1):11-26.
2003: Giampaolo Tortora; Fortunato Ciardiello
Antisense targeting protein kinase A type I as a drug for integrated strategies of cancer therapy.
Annals of the New York Academy of Sciences 2003;1002():236-43.
2003: Fortunato Ciardiello; Ferdinando De Vita; Michele Orditura; Sabino De Placido; Giampaolo Tortora
Epidermal growth factor receptor tyrosine kinase inhibitors in late stage clinical trials.
Expert opinion on emerging drugs 2003;8(2):501-14.
2003: Giampaolo Tortora; Fortunato Ciardiello
Antisense strategies targeting protein kinase C: preclinical and clinical development.
Seminars in oncology 2003;30(4 Suppl 10):26-31.
2003: Fortunato Ciardiello; Giampaolo Tortora
Epidermal growth factor receptor (EGFR) as a target in cancer therapy: understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs.
European journal of cancer (Oxford, England : 1990) 2003;39(10):1348-54.
2003: Giuseppe Di Lorenzo; Roberto Bianco; Giampaolo Tortora; Fortunato Ciardiello
Involvement of growth factor receptors of the epidermal growth factor receptor family in prostate cancer development and progression to androgen independence.
Clinical prostate cancer 2003;2(1):50-7.
2003: Giampaolo Tortora; Rosa Caputo; Vincenzo Damiano; Davide Melisi; Roberto Bianco; Gabriella Fontanini; Bianca Maria Veneziani; Sabino De Placido; Angelo Raffaele Bianco; Fortunato Ciardiello
Combination of a selective cyclooxygenase-2 inhibitor with epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 and protein kinase A antisense causes cooperative antitumor and antiangiogenic effect.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(4):1566-72.
2003: Fortunato Ciardiello; Rosa Caputo; Vincenzo Damiano; Rosa Caputo; Teresa Troiani; Donata Vitagliano; Francesca Carlomagno; Bianca Maria Veneziani; Gabriella Fontanini; Angelo Raffaele Bianco; Giampaolo Tortora
Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(4):1546-56.
2003: Giampaolo Tortora; Rosa Caputo; Vincenzo Damiano; Roberta Caputo; Teresa Troiani; Bianca Maria Veneziani; Sabino De Placido; Angelo Raffaele Bianco; Uwe Zangemeister-Wittke; Fortunato Ciardiello
Combined targeted inhibition of bcl-2, bcl-XL, epidermal growth factor receptor, and protein kinase A type I causes potent antitumor, apoptotic, and antiangiogenic activity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(2):866-71.
2002: Francesca Carlomagno; Donata Vitagliano; Teresa Guida; Fortunato Ciardiello; Giampaolo Tortora; Giancarlo Vecchio; Anderson Ryan; Gabriella Fontanini; Alfredo Fusco; Massimo Santoro
ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases.
Cancer research 2002;62(24):7284-90.
2002: Giampaolo Tortora; Fortunato Ciardiello
[Rationales for the integration of molecular and conventional therapies].
Tumori 2002;88(6):A9-13.
2002: Giuseppe Di Lorenzo; Giampaolo Tortora; Francesco P D'Armiento; Gaetano De Rosa; stefania staibano; Riccardo Autorino; Massimo D'Armiento; Michele De Laurentiis; Sabino De Placido; Giuseppe Catalano; Angelo Raffaele Bianco; Fortunato Ciardiello
Expression of epidermal growth factor receptor correlates with disease relapse and progression to androgen-independence in human prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(11):3438-44.
2002: Cataldo Bianco; Giampaolo Tortora; Roberto Bianco; Roberta Caputo; Bianca Maria Veneziani; Rosa Caputo; Vincenzo Damiano; Teresa Troiani; Gabriella Fontanini; David Raben; Stefano Pepe; Angelo Raffaele Bianco; Fortunato Ciardiello
Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective epidermal growth factor receptor-tyrosine kinase inhibitor ZD1839 (Iressa).
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(10):3250-8.
2002: Giampaolo Tortora; Fortunato Ciardiello
Protein kinase A as target for novel integrated strategies of cancer therapy.
Annals of the New York Academy of Sciences 2002;968():139-47.
2002: Fortunato Ciardiello; Giampaolo Tortora
Anti-epidermal growth factor receptor drugs in cancer therapy.
Expert opinion on investigational drugs 2002;11(6):755-68.
2002: Fortunato Ciardiello; Rosa Caputo; Giorgia Borriello; Donatella Del Bufalo; Annamaria Biroccio; Gabriella Zupi; Angelo Raffaele Bianco; Giampaolo Tortora
ZD1839 (IRESSA), an EGFR-selective tyrosine kinase inhibitor, enhances taxane activity in bcl-2 overexpressing, multidrug-resistant MCF-7 ADR human breast cancer cells.
International journal of cancer. Journal international du cancer 2002;98(3):463-9.
2002: Giampaolo Tortora; Fortunato Ciardiello; Vincenzo Damiano; Michele De Laurentiis; Elide Matano; Stefano Pepe; Matilde Pensabene; Giuseppe Catalano; Sabino De Placido; Angelo Raffaele Bianco
Preclinical and phase I study of oxaliplatin and topotecan in combination in human cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2002;13(3):392-8.
2002: Fortunato Ciardiello; Giampaolo Tortora; Sabino De Placido; Angelo Raffaele Bianco
ZD1839 (Iressa): preclinical studies and pharmacology.
Tumori 2002;88(1 Suppl 1):S155-7.
2001: Giampaolo Tortora; Rosa Caputo; Vincenzo Damiano; Gabriella Fontanini; Davide Melisi; Bianca Maria Veneziani; F Zunino; Angelo Raffaele Bianco; Fortunato Ciardiello
Oral administration of a novel taxane, an antisense oligonucleotide targeting protein kinase A, and the epidermal growth factor receptor inhibitor Iressa causes cooperative antitumor and antiangiogenic activity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(12):4156-63.
2001: Fortunato Ciardiello; Giampaolo Tortora
A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(10):2958-70.
2001: Giampaolo Tortora; Rosa Caputo; Vincenzo Damiano; Roberto Bianco; Gabriella Fontanini; S Cuccato; Sabino De Placido; Angelo Raffaele Bianco; Fortunato Ciardiello
Combined blockade of protein kinase A and bcl-2 by antisense strategy induces apoptosis and inhibits tumor growth and angiogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(8):2537-44.
2001: Fortunato Ciardiello; Rosa Caputo; Teresa Troiani; Giorgia Borriello; E R Kandimalla; Sudhir Agrawal; J Mendelsohn; Angelo Raffaele Bianco; Giampaolo Tortora
Antisense oligonucleotides targeting the epidermal growth factor receptor inhibit proliferation, induce apoptosis, and cooperate with cytotoxic drugs in human cancer cell lines.
International journal of cancer. Journal international du cancer 2001;93(2):172-8.
2001: Fortunato Ciardiello; Rosa Caputo; Roberto Bianco; Vincenzo Damiano; Gabriella Fontanini; S Cuccato; Sabino De Placido; Angelo Raffaele Bianco; Giampaolo Tortora
Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(5):1459-65.
2000: Giampaolo Tortora; Rosa Caputo; Vincenzo Damiano; Roberto Bianco; Jiandong Chen; Sudhir Agrawal; Angelo Raffaele Bianco; Fortunato Ciardiello
A novel MDM2 anti-sense oligonucleotide has anti-tumor activity and potentiates cytotoxic drugs acting by different mechanisms in human colon cancer.
International journal of cancer. Journal international du cancer 2000;88(5):804-9.
2000: Cataldo Bianco; Roberto Bianco; Giampaolo Tortora; Vincenzo Damiano; P Guerrieri; P Montemaggi; J Mendelsohn; Sabino De Placido; Angelo Raffaele Bianco; Fortunato Ciardiello
Antitumor activity of combined treatment of human cancer cells with ionizing radiation and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense oligonucleotide.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(11):4343-50.
2000: Fortunato Ciardiello; Roberto Bianco; Vincenzo Damiano; Gabriella Fontanini; Rosa Caputo; G Pomatico; Sabino De Placido; Angelo Raffaele Bianco; J Mendelsohn; Giampaolo Tortora
Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(9):3739-47.
2000: Giampaolo Tortora; Fortunato Ciardiello
Targeting of epidermal growth factor receptor and protein kinase A: molecular basis and therapeutic applications.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2000;11(7):777-83.
2000: Ciro Indolfi; Emilio Di Lorenzo; Antonio Rapacciuolo; Angela Maria Stingone; Eugenio Stabile; Antonio Leccia; Daniele Torella; Rosa Caputo; Fortunato Ciardiello; Giampaolo Tortora; Massimo Chiariello
8-chloro-cAMP inhibits smooth muscle cell proliferation in vitro and neointima formation induced by balloon injury in vivo.
Journal of the American College of Cardiology 2000;36(1):288-93.
2000: Giampaolo Tortora; Roberto Bianco; Vincenzo Damiano; Gabriella Fontanini; Sabino De Placido; Angelo Raffaele Bianco; Fortunato Ciardiello
Oral antisense that targets protein kinase A cooperates with taxol and inhibits tumor growth, angiogenesis, and growth factor production.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(6):2506-12.
2000: Fortunato Ciardiello; Rosa Caputo; Roberto Bianco; Vincenzo Damiano; G Pomatico; Sabino De Placido; Angelo Raffaele Bianco; Giampaolo Tortora
Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):2053-63.
2000: Fortunato Ciardiello; Rosa Caputo; G Pomatico; Michele De Laurentiis; Sabino De Placido; Angelo Raffaele Bianco; Giampaolo Tortora
Resistance to taxanes is induced by c-erbB-2 overexpression in human MCF-10A mammary epithelial cells and is blocked by combined treatment with an antisense oligonucleotide targeting type I protein kinase A.
International journal of cancer. Journal international du cancer 2000;85(5):710-5.
1999: Sabino De Placido; Chiara Carlomagno; Fortunato Ciardiello; Michele De Laurentiis; Stefano Pepe; Angela Ruggiero; Giampaolo Tortora; Luigi Panico; A D'Antonio; Guido Pettinato; Giuseppe Petrella; Angelo Raffaele Bianco
Measurement of neovascularization is an independent prognosticator of survival in node-negative breast cancer patients with long-term follow-up.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(10):2854-9.
1999: Nicola Normanno; Giampaolo Tortora; A De Luca; G Pomatico; Amelia Casamassimi; Sudhir Agrawal; J Mendelsohn; Angelo Raffaele Bianco; Fortunato Ciardiello
Synergistic growth inhibition and induction of apoptosis by a novel mixed backbone antisense oligonucleotide targeting CRIPTO in combination with C225 anti-EGFR monoclonal antibody and 8-Cl-cAMP in human GEO colon cancer cells.
Oncology reports 1999;6(5):1105-9.
1999: Fortunato Ciardiello; Roberto Bianco; Vincenzo Damiano; Sonya De Lorenzo; Stefano Pepe; Sabino De Placido; Z Fan; J Mendelsohn; Angelo Raffaele Bianco; Giampaolo Tortora
Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(4):909-16.
1999: Giampaolo Tortora; Rosa Caputo; G Pomatico; Stefano Pepe; Angelo Raffaele Bianco; Sudhir Agrawal; J Mendelsohn; Fortunato Ciardiello
Cooperative inhibitory effect of novel mixed backbone oligonucleotide targeting protein kinase A in combination with docetaxel and anti-epidermal growth factor-receptor antibody on human breast cancer cell growth.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(4):875-81.
1998: Fortunato Ciardiello; Rosa Caputo; Roberto Bianco; Vincenzo Damiano; G Pomatico; Stefano Pepe; Angelo Raffaele Bianco; Sudhir Agrawal; J Mendelsohn; Giampaolo Tortora
Cooperative inhibition of renal cancer growth by anti-epidermal growth factor receptor antibody and protein kinase A antisense oligonucleotide.
Journal of the National Cancer Institute 1998;90(14):1087-94.
1998: Giampaolo Tortora; Rosa Caputo; Vincenzo Damiano; Roberto Bianco; Stefano Pepe; G Pomatico; Angelo Raffaele Bianco; Z Jiang; Sudhir Agrawal; Fortunato Ciardiello
Cooperative antitumor effect of mixed backbone oligonucleotides targeting protein kinase A in combination with cytotoxic drugs or biologic agents.
Antisense & nucleic acid drug development 1998;8(2):141-5.
1998: Fortunato Ciardiello; Giampaolo Tortora
Interactions between the epidermal growth factor receptor and type I protein kinase A: biological significance and therapeutic implications.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(4):821-8.
1998: Gabriella Fontanini; Michele De Laurentiis; S Vignati; S Chinè; Marco Lucchi; V Silvestri; Alfredo Mussi; Sabino De Placido; Giampaolo Tortora; Angelo Raffaele Bianco; W Gullick; Carlo Alberto Angeletti; Generoso Bevilacqua; Fortunato Ciardiello
Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(1):241-9.
1998: Fortunato Ciardiello; M Dixit; G di Isernia; Vincenzo Damiano; Roberto Bianco; Angelo Raffaele Bianco; Carlos L Arteaga; Giampaolo Tortora
Down-regulation of type I protein kinase A by transfection of human breast cancer cells with an epidermal growth factor receptor antisense expression vector.
Breast cancer research and treatment 1998;47(1):57-62.
1997: Giampaolo Tortora; G di Isernia; C Sandomenico; Roberto Bianco; G Pomatico; Stefano Pepe; Angelo Raffaele Bianco; Fortunato Ciardiello
Synergistic inhibition of growth and induction of apoptosis by 8-chloro-cAMP and paclitaxel or cisplatin in human cancer cells.
Cancer research 1997;57(22):5107-11.
1997: Giampaolo Tortora; Rosa Caputo; Vincenzo Damiano; Roberto Bianco; S Pepe; A R Bianco; Z Jiang; Sudhir Agrawal; Fortunato Ciardiello
Synergistic inhibition of human cancer cell growth by cytotoxic drugs and mixed backbone antisense oligonucleotide targeting protein kinase A.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(23):12586-91.
1997: Cataldo Bianco; Giampaolo Tortora; G Baldassarre; Rosa Caputo; Gabriella Fontanini; S Chinè; Angelo Raffaele Bianco; Fortunato Ciardiello
8-Chloro-cyclic AMP inhibits autocrine and angiogenic growth factor production in human colorectal and breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(3):439-48.
1997: Angelo Raffaele Bianco; Chiara Carlomagno; Michele De Laurentiis; Sabino De Placido; Giampaolo Tortora; Fortunato Ciardiello
Prognostic factors in human colorectal cancer.
Tumori 1997;83(1 Suppl):S15-8.
1996: Fortunato Ciardiello; Vincenzo Damiano; Roberto Bianco; C Bianco; Gabriella Fontanini; Michele De Laurentiis; Sabino De Placido; J Mendelsohn; Angelo Raffaele Bianco; Giampaolo Tortora
Antitumor activity of combined blockade of epidermal growth factor receptor and protein kinase A.
Journal of the National Cancer Institute 1996;88(23):1770-6.
1996: Gustavo Baldassarre; C Bianco; Giampaolo Tortora; A Ruggiero; Mark M Moasser; Ethan Dmitrovsky; Angelo Raffaele Bianco; Fortunato Ciardiello
Transfection with a CRIPTO anti-sense plasmid suppresses endogenous CRIPTO expression and inhibits transformation in a human embryonal carcinoma cell line.
International journal of cancer. Journal international du cancer 1996;66(4):538-43.
1996: Nicola Normanno; C Bianco; Vincenzo Damiano; E de Angelis; M P Selvam; M Grassi; G Magliulo; Giampaolo Tortora; Angelo Raffaele Bianco; J Mendelsohn; David S Salomon; Fortunato Ciardiello
Growth inhibition of human colon carcinoma cells by combinations of anti-epidermal growth factor-related growth factor antisense oligonucleotides.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(3):601-9.
1996: Luigi Panico; A D'Antonio; G Salvatore; Ernesto Mezza; Giampaolo Tortora; Michele De Laurentiis; Sabino De Placido; Thomas J Giordano; M Merino; D S Salomon; W J Mullick; Guido Pettinato; S J Schnitt; Angelo Raffaele Bianco; Fortunato Ciardiello
Differential immunohistochemical detection of transforming growth factor alpha, amphiregulin and CRIPTO in human normal and malignant breast tissues.
International journal of cancer. Journal international du cancer 1996;65(1):51-6.
1996: Pierosandro Tagliaferri; Giampaolo Tortora; Rosario Guarrasi; Vincenzo Damiano; A Ruggiero; D Morelli; Michele Caraglia; Roberto Bianco; G di Isernia; Stefano Pepe; Carlos L Arteaga; B C Langton-Webster; Angelo Raffaele Bianco; Fortunato Ciardiello
Differential sensitivity to non-major histocompatibility complex-restricted recombinant interleukin 2-activated lymphocyte killing of human mammary epithelial MCF-10A cells overexpressing oncogenes or protein kinase A subunits.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(1):207-14.
1995: Nicola Normanno; M P Selvam; C Bianco; Vincenzo Damiano; E de Angelis; M Grassi; G Magliulo; Giampaolo Tortora; David S Salomon; Fortunato Ciardiello
Amphiregulin anti-sense oligodeoxynucleotides inhibit growth and transformation of a human colon carcinoma cell line.
International journal of cancer. Journal international du cancer 1995;62(6):762-6.
1995: Giampaolo Tortora; Fortunato Ciardiello; Vincenzo Damiano; Stefano Pepe; C Bianco; G di Isernia; S L Davies; P North; Adrian L Harris; Ian D Hickson
Cyclic AMP-dependent protein kinase type I is involved in hypersensitivity of human breast cells to topoisomerase II inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(1):49-56.
1994: Giampaolo Tortora; Stefano Pepe; C Bianco; Vincenzo Damiano; A Ruggiero; Gustavo Baldassarre; C Corbo; Yoon S Cho-Chung; Angelo Raffaele Bianco; Fortunato Ciardiello
Differential effects of protein kinase A sub-units on Chinese-hamster-ovary cell cycle and proliferation.
International journal of cancer. Journal international du cancer 1994;59(5):712-6.
1994: Giampaolo Tortora; Stefano Pepe; C Bianco; Gustavo Baldassarre; Alfredo Budillon; Timothy Clair; Yoon S Cho-Chung; Angelo Raffaele Bianco; Fortunato Ciardiello
The RI alpha subunit of protein kinase A controls serum dependency and entry into cell cycle of human mammary epithelial cells.
Oncogene 1994;9(11):3233-40.
1994: P S North; S L Davies; Fortunato Ciardiello; Vincenzo Damiano; C Bianco; Stefano Pepe; Angelo Raffaele Bianco; Adrian L Harris; Ian D Hickson; Giampaolo Tortora
Overexpression of the RI alpha subunit of protein kinase A confers hypersensitivity to topoisomerase II inhibitors and 8-chloro-cyclic adenosine 3'5'-monophosphate in Chinese hamster ovary cells.
Cancer research 1994;54(15):4123-8.
1994: Giampaolo Tortora; Alfredo Budillon; H Yokozaki; Timothy Clair; Stefano Pepe; GR Merlo; C Rohlff; Yoon S Cho-Chung
Retroviral vector-mediated overexpression of the RII beta subunit of the cAMP-dependent protein kinase induces differentiation in human leukemia cells and reverts the transformed phenotype of mouse fibroblasts.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(7):753-9.
1994: Fortunato Ciardiello; Giampaolo Tortora; C Bianco; M P Selvam; F Basolo; G Fontanini; F Pacifico; Nicola Normanno; R Brandt; M G Persico
Inhibition of CRIPTO expression and tumorigenicity in human colon cancer cells by antisense RNA and oligodeoxynucleotides.
Oncogene 1994;9(1):291-8.
1994: Stefano Pepe; A Ruggiero; Giampaolo Tortora; Fortunato Ciardiello; C Garbi; H Yokozaki; Yoon S Cho-Chung; Timothy Clair; B S Skalhegg; Angelo Raffaele Bianco
Flow-cytometric detection of the RI alpha subunit of type I cAMP-dependent protein kinase in human cells.
Cytometry 1994;15(1):73-9.
1993: Fortunato Ciardiello; Giampaolo Tortora; Stefano Pepe; C Bianco; Gustavo Baldassarre; A Ruggiero; C Bianco; M P Selvam; Angelo Raffaele Bianco
Reduction of RI alpha subunit of cAMP-dependent protein kinase expression induces growth inhibition of human mammary epithelial cells transformed by TGF-alpha, c-Ha-ras, and c-erbB-2 genes.
Annals of the New York Academy of Sciences 1993;698():102-7.
1993: Fortunato Ciardiello; C Bianco; Nicola Normanno; Gustavo Baldassarre; Stefano Pepe; Giampaolo Tortora; Angelo Raffaele Bianco; David S Salomon
Infection with a transforming growth factor alpha anti-sense retroviral expression vector reduces the in vitro growth and transformation of a human colon cancer cell line.
International journal of cancer. Journal international du cancer 1993;54(6):952-8.
1993: Giampaolo Tortora; Stefano Pepe; Anna Maria Cirafici; Fortunato Ciardiello; Antonio Porcellini; Timothy Clair; Giulia Colletta; Yoon S Cho-Chung; A R Bianco
Thyroid-stimulating hormone-regulated growth and cell cycle distribution of thyroid cells involve type I isozyme of cyclic AMP-dependent protein kinase.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(5):359-65.
1993: H Yokozaki; Alfredo Budillon; Giampaolo Tortora; S Meissner; S L Beaucage; K Miki; Yoon S Cho-Chung
An antisense oligodeoxynucleotide that depletes RI alpha subunit of cyclic AMP-dependent protein kinase induces growth inhibition in human cancer cells.
Cancer research 1993;53(4):868-72.
1993: Fortunato Ciardiello; Stefano Pepe; C Bianco; Gustavo Baldassarre; A Ruggiero; C Bianco; M P Selvam; Angelo Raffaele Bianco; Giampaolo Tortora
Down-regulation of RI alpha subunit of cAMP-dependent protein kinase induces growth inhibition of human mammary epithelial cells transformed by c-Ha-ras and c-erbB-2 proto-oncogenes.
International journal of cancer. Journal international du cancer 1993;53(3):438-43.
1992: A Pinto; Donatella Aldinucci; Valter Gattei; Vittorina Zagonel; Giampaolo Tortora; Alfredo Budillon; Yoon S Cho-Chung
Inhibition of the self-renewal capacity of blast progenitors from acute myeloblastic leukemia patients by site-selective 8-chloroadenosine 3',5'-cyclic monophosphate.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):8884-8.
1992: H Yokozaki; Giampaolo Tortora; Stefano Pepe; Erik Maronde; Hans-Gottfried Genieser; B Jastorff; Yoon S Cho-Chung
Unhydrolyzable analogues of adenosine 3':5'-monophosphate demonstrating growth inhibition and differentiation in human cancer cells.
Cancer research 1992;52(9):2504-8.
1991: Stefano Pepe; Giampaolo Tortora; P D Noguchi; Gerald E Marti; G C Washington; Yoon S Cho-Chung
Effects of 8-chloroadenosine 3',5'-monophosphate and N6-benzyl-cyclic adenosine 5'-monophosphate on cell cycle kinetics of HL-60 leukemia cells.
Cancer research 1991;51(23 Pt 1):6263-7.
1991: Giampaolo Tortora; Stefano Pepe; H Yokozaki; S Meissner; Yoon S Cho-Chung
Cooperative effect of 8-Cl-cAMP and rhGM-CSF on the differentiation of HL-60 human leukemia cells.
Biochemical and biophysical research communications 1991;177(3):1133-40.
1991: Fiorella Guadagni; Giampaolo Tortora; Mario Roselli; Timothy Clair; Yoon S Cho-Chung; Jeffrey Schlom; John W Greiner
Carcinoembryonic antigen regulation in human colorectal tumor cells by a site-selective cyclic AMP analogue: a comparison with interferon-gamma.
International journal of cancer. Journal international du cancer 1991;48(3):413-22.
1991: Giampaolo Tortora; H Yokozaki; Stefano Pepe; Timothy Clair; Yoon S Cho-Chung
Differentiation of HL-60 leukemia by type I regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(5):2011-5.
1991: Yoon S Cho-Chung; Timothy Clair; Giampaolo Tortora; H Yokozaki; Stefano Pepe
Suppression of malignancy targeting the intracellular signal transducing proteins of cAMP: the use of site-selective cAMP analogs, antisense strategy, and gene transfer.
Life sciences 1991;48(12):1123-32.
1991: Yoon S Cho-Chung; Timothy Clair; Giampaolo Tortora; H Yokozaki
Role of site-selective cAMP analogs in the control and reversal of malignancy.
Pharmacology & therapeutics 1991;50(1):1-33.
1990: Giampaolo Tortora; Yoon S Cho-Chung
Type II regulatory subunit of protein kinase restores cAMP-dependent transcription in a cAMP-unresponsive cell line.
The Journal of biological chemistry 1990;265(30):18067-70.
1990: Fortunato Ciardiello; Giampaolo Tortora; N Kim; Timothy Clair; S Ally; David S Salomon; Yoon S Cho-Chung
8-Chloro-cAMP inhibits transforming growth factor alpha transformation of mammary epithelial cells by restoration of the normal mRNA patterns for cAMP-dependent protein kinase regulatory subunit isoforms which show disruption upon transformation.
The Journal of biological chemistry 1990;265(2):1016-20.
1990: Giampaolo Tortora; Timothy Clair; Yoon S Cho-Chung
An antisense oligodeoxynucleotide targeted against the type II beta regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(2):705-8.
1989: S Ally; Timothy Clair; D Katsaros; Giampaolo Tortora; H Yokozaki; R A Finch; T L Avery; Yoon S Cho-Chung
Inhibition of growth and modulation of gene expression in human lung carcinoma in athymic mice by site-selective 8-Cl-cyclic adenosine monophosphate.
Cancer research 1989;49(20):5650-5.
1989: MI Mednieks; H Yokozaki; GR Merlo; Giampaolo Tortora; Timothy Clair; S Ally; E Tahara; Yoon S Cho-Chung
Site-selective 8-Cl-cAMP which causes growth inhibition and differentiation increases DNA (CRE)-binding activity in cancer cells.
FEBS letters 1989;254(1-2):83-8.
1989: Giampaolo Tortora; Timothy Clair; D Katsaros; S Ally; Oscar R Colamonici; Leonard M Neckers; Pierosandro Tagliaferri; T Jahnsen; R K Robins; Yoon S Cho-Chung
Induction of megakaryocytic differentiation and modulation of protein kinase gene expression by site-selective cAMP analogs in K-562 human leukemic cells.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(8):2849-52.
1989: Giampaolo Tortora; Fortunato Ciardiello; S Ally; Timothy Clair; David S Salomon; Yoon S Cho-Chung
Site-selective 8-chloroadenosine 3',5'-cyclic monophosphate inhibits transformation and transforming growth factor alpha production in Ki-ras-transformed rat fibroblasts.
FEBS letters 1989;242(2):363-7.
1989: Yoon S Cho-Chung; Timothy Clair; Pierosandro Tagliaferri; S Ally; D Katsaros; Giampaolo Tortora; Len Neckers; T L Avery; G W Crabtree; R K Robins
Site-selective cyclic AMP analogs as new biological tools in growth control, differentiation, and proto-oncogene regulation.
Cancer investigation 1989;7(2):161-77.
1988: Fortunato Ciardiello; B Sanfilippo; K Yanagihara; N Kim; Giampaolo Tortora; R H Bassin; W R Kidwell; David S Salomon
Differential growth sensitivity to 4-cis-hydroxy-L-proline of transformed rodent cell lines.
Cancer research 1988;48(9):2483-91.
1988: Pierosandro Tagliaferri; D Katsaros; Timothy Clair; S Ally; Giampaolo Tortora; Len Neckers; B Rubalcava; Z Parandoosh; Y A Chang; G R Revankar
Synergistic inhibition of growth of breast and colon human cancer cell lines by site-selective cyclic AMP analogues.
Cancer research 1988;48(6):1642-50.
1988: Giampaolo Tortora; Pierosandro Tagliaferri; Timothy Clair; Oscar R Colamonici; Leonard M Neckers; R K Robins; Y S Cho-Chung
Site-selective cAMP analogs at micromolar concentrations induce growth arrest and differentiation of acute promyelocytic, chronic myelocytic, and acute lymphocytic human leukemia cell lines.
Blood 1988;71(1):230-3.
1987: D Katsaros; Giampaolo Tortora; Pierosandro Tagliaferri; Timothy Clair; S Ally; Len Neckers; R K Robins; Yoon S Cho-Chung
Site-selective cyclic AMP analogs provide a new approach in the control of cancer cell growth.
FEBS letters 1987;223(1):97-103.